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Transcript of Filtration For Pharmaceutical Applicationjtrooz.com/Catalog/Membrane.pdf · pressure drop, which...

  • Filtration For Pharmaceutical Application

  • Contents

    Introduction

    Application

  • Filtration Range

    Particle 10-4 10-3 10-2 10-1 1.0 10 102 103

    ( μm)

    Average Molecular 100 200 20,000 500,000

    Fabric Filtration

    Mesh

    Micro-Filtration

    Ultra-Filtration

    NF

    RO

    Filtration Range

    Red Blood Cell

    Emulsion

    Oil Emu

    Paint Pigments

    Bacterial Sand

    Hair Protein, Enzyme

    Carbon Granules

    Virus

    Radiating Atom

    Soluble Pigments

    VOC, PCD, Susp. Oil

    Metal Ion

    Membrane

    Type

    Pore Size

    weight

  • Micro Filtration

    Wound String Filter

    Melt Blown Filter

    Activated Carton Filter

    Pleated Cartridge Filter

    Filter Bag

    ….

  • Filtration of Pharmaceuticals

    Gas Filter

    API Filter

    Buffer Filter

    Injection Filter

    Serum Filter

  • Gas Filtration Process

    Oil and Water Remove System

    Sterile

    Filtration Sterile

    Filtration

    Pre-Filtration

    Vent

    Vapour

    Stainless Steel Filter

    Fermenter Container sterile

    CF sterile

    Product Sterile

  • Pre-Filtration(0.01umGF)

    Sterile Filtration(0.01umPTFE)

    Stainless Steel Filtration(2um)

  • API Filtration Process

  • Pre-Filtration(0.45um)

    Sterile Filtration(0.22um)

  • Buffer Filtration Process

    Tank Pre-Filtration Sterile Filtration

    Storage

    Tank Analysis

  • Pre-Filtration(0.45um)

    Sterile Filtration(0.22um)

  • Injection Filtration Process

  • Titanium stick filter (1um)、Pre-Filtration(1umPP pl

    eated)

    2 level Pre-filtration(0.45umPES、0.45umPVDF)

    Sterile Filtration(0.22umPES 、0.45um PVDF)

  • Serum Filtration Process

  • Clarification Filtration(5um)

    Pre-Filtration(0.45um)

    Sterile Filtration(0.22um, 0.1um)

  • Conclusion

    For Pharmaceutical application, our cartridge filter can b

    e used as Pre-Filtration System, Sterile Filtration and G

    as Filtration.

    Any more information needed, please feel free to contact

    me at any time.

  • MaterialDiameter/mmFeatures

    *We still offer MCE customized membrane etc.

  • MS® sample vials

    2mL Autosampler Vials for HPLC

    8-425/9-425/10-425/Crimp top/Snap top

    2mL Dimension 32*11.6mm

    Type I, 33 expansion glass(Clear)

    Type I, 51 expansion glass(Amber)

    Assembled Caps and Septa for 2mL Autosa-mpler Vials

    Design of the Neck

    Material

    Septa

    8-425/9-425/10-425 Crimp top/ Snap top

    Polyethylene AluminumPolyethylene

    1.Pre-slit Blue PTFE/White Silicone Septa2.Red PTFE/White Silicone Septa3. White PTFE/Red Silicone Septa

    Design of the Neck

    Volume

    Type of Glass

    Dimension

    24-400

    20/30/40mL

    Type I, 33 expansion glass(Clear)Type I, 51 expansion glass(Amber)

    57*27.5/72.5*27.595*27.5

    Assembled Caps and Septa for Storage Vials

    Design of the NeckMaterialSepta

    24-400PE, center hole/PE, closed topWhite PTFE/Nature Silicone Septa

    MS Advantage

    Contact Us

    About us

    Headspace Vials

    Caps and Septas for Headspace vials

    Screw Vials for Storage

  • 01

    About MS

    02

    Manufacturing& Laboratories

    03

    Research & Development

    04

    Products

    05

    What Can We Do

    Contents

  • Ⅰ. About MS - General Information

    Location: Headquarter in WA, USA

    Employees: about 250

    Main Business Scope: Membrane & Filter

    Started Business: 2006 USA; 2008 China

    Plants: R&D Center: Office:

    1) Seattle, WA, USA Nantong, Jiangsu, China Seattle, WA, USA

    2) Nantong, Jiangsu, China Shanghai, China Tokyo, Japan

    3) Chongqing, China Wuhan, Hubei, China Wuhan, Hubei, China

    Shanghai

  • Ⅰ. About MS - General Information

    2006.06: Founded Membrane Solutions USA

    2007.08: Imported German Brand Membrane for

    domestic Market in USA & China

    2008.02: Founded New and the 1st Plant in Nantong

    2009.03: ISO 9001 Certified

    2009.06: Manufacturing Lab Filtration Products

    2010.08: Manufacturing Industry Filtration Products

    2011.06: First Flat Sheet Microfiltration Nylon

    2011.09: CE Certified

    2013.06: FDA Registered

    2014.12: 60M Syringe Filters, #1 in the world

    2014.12: OEM for Top 5 account in the world

    2015.12: Start Assembly in USA

    History

    2009 2011 2013

    轻 点 此 处 输入文字内容

    20152010 2012 2014 20162006

    MS was Founded in MA, USA

    2009

    ISO9001 and Lab Products

    2013

    FDA Registered and Residential Products

    2015

    Start Assembly in USA

    2008

    China 1st Plant in Nantong

    2011

    CE Certified and Industry Products

    2014

    60M Syringe Filters, #1 in the world

    2016

  • Ⅰ. About MS - Organization

    MS (USA)

    MS(USA)

    MS(China)

    MS(USA)

    MS(China)

    MS(Japan)

    R&D, Tech support

    Operational& Support

    Sales Dept.

    Manufacturing

  • Ⅰ. About MS - Certificates

  • Ⅰ. About MS – Sales/Marketing and R&D

    R&D:

    • Core Technology – Air & Liquid Filter Membrane

    • Filtration cover microfiltration-

    ultrafiltration- Reverse Osmosis (RO)

    • Continual new products and application

    development

    • Lab-to-Industry Application Establishment

    Sales & Marketing:

    • Marketing Segment

    • Sole Distributor

    • Special OEM team

    • Dot to Dot training, SOP training

    • More than 20 trade show every year

    • E- business ( Amazon & E-bay)

  • Ⅰ. About MS – Global Warehouse & Sales Network

    Europe Spain & Italy

    ChinaUSA, Ohio & Dallas

    South America : Brazil

    Oceania

    Africa

  • Ⅱ. Manufacturing & Laboratories

    Class 100,000 clean room QC Laboratory in Nantong

    Manufacturing in Nantong

  • Ⅱ. Manufacturing & Laboratories

    Validation Laboratory in Shanghai Application Laboratory in Wuhan

  • Ⅲ. Research and Development

    Microfiltration membrane

    PES HydrophilicFast Flow

    PVDFHydrophobicHydrophilic

    PTFEHydrophobicHydrophilic

    NylonHydrophilic

    Ultrafiltration membrane

    PVDFHydrophilic

    PVDFHydrophilicNY Supported

    PES Hydrophilic

    Reverse Osmosis membrane

  • Ⅲ. Research and Development - Instruments

  • Ⅳ. Products Family

    Lab Filtration

    请输入标题

    • HPLC Syringe Filter

    • Sterilized Syringe Filter

    • 50mm Venting Filter

    • Gridded Membrane Filter

    • Disc Membrane Filter

    • Blotting Membrane

    • Sample Vial

    • SPE Column

    • Ultrapure Water System

    • RO Membrane

    • Pure Water System

    • UF Residential Membrane

    • Water Pitcher

    • Life Straw

    • POE Water Filter

    • Micro-filtration membrane

    • UF membrane

    • RO Membrane

    • Cartridge Filter

    • MBR Skid System

    • Ultra-pure Water system

    Lab Filtration Residential Industry

  • Ⅳ. Products – Lab Filtration

    Membrane Selection Guide

  • Φ4mm Φ50mm

    Syringe Filter

    Ⅳ. Products – Lab Filtration

    Allpure

    Simplepure

    Chrompure

    Φ13mm Φ25mm

    Superpure

    Bepure

    Biopure

    Φ17mm Φ30mm Φ33mm

  • Ⅳ. Products – Lab Filtration

    2ml Sample Vial

    HeadSpace Vial

    Micro-Sampling Vial & inserts

    Storage Vial

  • Ⅳ. Products – Lab Filtration

    MCE Gridded Membrane Filter

    White gridded membranes are designed for General Purpose

    Examination of all microorganisms, the recovery and retention

    of E. Coli bacteria in water/wastewater analysis as well as

    other microbiological tests.

    Black MCE are available plain for automatic colony counting

    applications, as well as gridded to assist in manual counting

    procedures, analysis of yeast and mold.

  • Ⅳ. Products – Industry Filtration

    Depth Filter (Standard & Non Standard )

    String Wound Melt Blown PP Pleated GF Pleated PE Pleated Activated carbon filter

    Membrane Pleated Filter (Standard & Non Standard)

    PES Pleated

    NY Pleated

    PTFE Pleated

    PVDF Pleated

    UPE Pleated

    PSPleated

    MCE Pleated

    Cartridge filter

  • Ⅳ. Products – Industry Filtration

    Ultra-filtration membrane & Module

  • Ⅴ. What Can We Do

    n Facility Background

    State-of-art welding

    technology

    Exclusive OEM Service

    Automatic Production

    High Quality and Stable Products Wide Application

    Complete Production Line

    n Friendly Choice

    Four Steps QC High Throughput /Flow rate COA Delivery

    n Quality Control

  • STAY PURE

    Bag Material

    Filter Material

    Size/mm

    Pore Size/μm

    PES/PTFE/PP/Nylon/MCE

    0.1/0.22/0.45/1/3/5

    Φ67X90; Φ67X112Φ65X46; Φ75X165

    Size/mm

    Pore Size/um

    Temperature/F

    Features

    Application

    Picture

    PP/PE Needled Felt/Melt Blown

    1/3/5/10/25/50/100

    200/300

    25/50/100/150/200/250/300

    275

    #01:Φ180*420 L ; #2: Φ180*810 L#3: Φ102*230 L; #4: Φ102*380 L

    Nylon monofilament mesh

    100% PP/PE, melt blown; welded seam construction; PP seal/stainless steel ring; low pressure drop

    Prefiltering before membrane, Automotive coatings, chemicals, resins, edible oils and other fluid applications

    Application: purification for various chemical material and medicaments; filtration for high additional liquid, small flux liquid and precious metal; filtration for strong corrosive solvent and gas filtration; filtration for pharmaceutical industry, chemical industry and biotechnology.

    Features-HOSEBARE/MNPT; PP housing; Each filter experiences 100% integrity test; Thermal bonding; different pore size

    Sewn/weld seam construction; PP seal/stainless steel ring; uneasy to be deformed, high tensile strength; good stability

    Prefiltering, filtration for automobile degreasing, raw water filtration, coarse filtration, circulating water filtration

    Membrane Solutions is a filtration company focuses on advanced membrane technology. People-oriented principle, qualified filtration products, excellent management concept and sales mode are highly appreciated by MS, who is devoted in improvement of developing filtration field. MS has moved into China since 2005, And now, with a plant and a R&D base in Nantong, three sales branches in Nantong, Shanghai, Wuhan, respectively, MS starts its aggressively developing strategy in Chinese filtration field. In 2010, HQ from Texas, America further reinforced investment in China, which means China becomes an important part of MS global development. According to perfect different walks of life. At present, MS products are widely applied in highly developed market, such as electronic and medical purification field, civil and industrial and municipal water treatment, etc.

    MS will continue to make effort in solving and challenging difficulties in water treatment on the basis of sustainable development. We will make our social contribution through satisfying customer’s requirement on clean water, high energy efficiency, and environmental protection.

    ISO 9001 Certification & CE MarketCertificate of FDA Registration Global Supply Chain and Efficient Customer Service Glass 100,000 clean Room Quick Delivery 5-7 days guaranteed OEM option, Private Labeling Service Consistent QA and Stable Product Supply

    Filter Bag

    Capsule Filter

    Toll free: 1-214-775-2940Fax:732-412-4040Address:JP Morgan International Plaza Suite 650, 14241 Dallas Parkway, Dallas, TX,USWebsite:www.membrane-solutions.com

    Tel: 0086-21-61478117Fax:0086-21-51687551Adress:2202, No.1759 North Zhongshan Road, ShanghaiWebsite:www.membrane-solutions.com

    USA

    China

    Inquiry

    Toll free: 0066-33-800658Adress:Suite #504,1-19-2 Nihonbashi, kakigaracho,chou-ku,Tokyo 103-0014

    Please write to [email protected]

    Online order

    Please write to [email protected]

    Japan

    Contact Us

    About Us

    MS Features

  • Material

    Length (inch)

    Core

    Micron Rating(μm) 0.5/1/5/10/20/30

    DOE/SOE/Flat/Fin/222/226

    AquaPure Classic Series

    PP/CT

    10/20/30/40

    PP/Stainless Steel

    Connection Type

    MS String Wound cartridge filter is a kind of deep filter cartridge, which is made of the textile fabric string(Polypropylene, absorbentcotton and so on) previously winding onto the multi-hole axies according to the specific technology. The double O-ring sealing system ensures positive sealing of the filter cartridge within the filter housing and virtually eliminates and potential for bypass. The all polypropylene construction provides excellent compatibility in a wide variety of process streams.

    Material

    Length (inch)

    Core

    Micron Rating(μm) 0.22/5

    Silicon/EPDM/Viton/NBR

    Polypropylene

    10/20/30/40/50/60

    DOE/SOE/Flat/Fin/222/226

    Seal material

    MS Polypure-AB Absolute PP pleated Cartridge Filter uses the raw materials which have permitted by FDACR21. This type of cartridge tolerates a variety of chemical solvents, used in the filtration of ordinary or corrosive fluid. Application---Food and Beverage Processing, High Purity Chemicals, RO Pretreatment β≥1000Filtration Efficiency: ≥99%

    Material

    Length (inch)

    Outside Diameter(mm)

    Micron Rating(μm) 1//5/10

    28mm, 30mm

    Bituminous and coconut shell carbon

    5/10/20/30

    63mm/115mm Inside Diameter(mm)

    MS ActivatePure CTO series carbon filter cartridge is shaped by extruding the premium grade activated carbon with food grade additives continuously, no release of carbon fines. The extrusion process allows more carbon, but a lower pressure drop, which enables the filter to deliver extended life while removing sediment, chlorine, taste, odor and organic contaminants from water, aqueous solutions or suspensions effectively. Application:Drinking Water, Swimming Pool, Chemical & petrochemical industry

    Material

    Length (inch)

    Outside Diameter(mm)

    Micron Rating(μm) 5/10

    28mm

    PAC impregnated cellulose

    5/10/20/30

    58mm/112mm Inside Diameter(mm)

    MS carbon impregnated cellulose cartridge offer an economically solutions for general-purpose water filtration needs. The special filter media combine the benefits of both the sediment filter and the carbon block into a single cartridge with its outside fiber media removing sediments and the powdered activated carbon on the filter matrix absorbing chlorine, odor, taste, voc, organic chemicals etc.

    MS Item

    CRSP-3060

    CRSP-3061

    CRSP-3077

    OD

    2 3/4

    2 3/4

    4 1/4

    9 3/4

    9 3/4

    4

    1 1/16

    1 1/16

    1 15/16

    1 1/16

    1 1/16

    1 15/16

    Length Top Bottom

    MS KleenPure replacement filter is used in the swimming pool and spa, various types can be manufactured by us and we could also satisfy all the requirements of your custom sizes. The cleaness and your health start from here. All KleenPure filter are manufactured using the best materials possible. MS designs and builds the highest quality and most sufficient pool and spa filters in the world.

    Material

    Length (inch)

    Core

    Micron Rating(μm) 0.22/0.45/1.0/5.0

    Silicon/EPDM/Viton/NBR

    Polyether-sulfone

    10/20/30/40/50/60

    DOE/SOE/Flat/Fin/222/226

    Seal material

    MS SteriPure Series pleated cartridge are manufactured with advance hydrophilic asymmetric polyetheure-sulfone membranes and all polypropylene components. The low protein binding nature of the filter membrane ensures suitability in many critical applications. The PES membrane provides accurate particle cut-offs and is compatible with a broad range of chemicals.

    Material

    Length (inch)

    Core

    Micron Rating(μm) 0.22/0.45/1.0/5.0

    Silicon/EPDM/Viton/NBR

    Polyether-sulfone

    10/20/30/40/50/60

    DOE/SOE/Flat/Fin/222/226

    Seal material

    MS Fluorpure cartridge filter uses a natural hydrophobic PTFE membrane along with non-woven support that provide an economical alternative to all fluorine media cartridges. All non-PTFE components utilizes high density polyethylene to ensure exceptionally low organic and metal ion extractables.

    Excellent liquid and gas flow rates;100% integrity tested in cleanroom environment

    Material

    Length (inch)

    Connection Type

    Micron Rating(μm) 0.5/1/5/10/20/30

    CRMPP0400500

    MicroPure Classic Series

    PP

    10/20/30/40

    DOE/SOE/Flat/Fin/222/226

    Order Eg

    MS MicroPure Classic Series is pure polypropylene depth filter, which offers better protection of RO membrane system.

    Features: Graded pore structure enhances Dirt holding capacity; All PP construction provides good resistance to both organic and inorganic solvent; High contaminant removal efficiency; PP core provides excellent strength of cartridge filter; Long service life. Application: Pre-RO, Electronic Chemical Solvents; Drinking Water Treatment, Cooling Water

    Material

    Length (inch)

    Connection Type

    Micron Rating(μm) 0.1/0.22/0.45/1/5/10

    Silicon/EPDM/Viton/NBR

    PolyPure Classic Series

    Polypropylene

    10/20/30/40/50/60/70

    DOE/SOE/Flat/Fin/222/226

    Seal material

    MS PolyPure Classic Cartridge Filer is constructed of micro polypropylene media and nonwoven or silk net support and is ideally suited for the removal of agglomerated particles and gels. Deep, wide pleats for long service life in liquids with high levels of suspended solids and designed for reverse flow cleaning and construction optimized for consistent performance under variation in flow.

    Application: Food and beverage, Chemical industry, oil industry Filtration Area: 0.65 m2.

    String Wound Cartridge Filter AB Absolute Pleated Filter ActivePure CTO Series

    ActivePure CIC Series

    KleenPure Replacement Filter Cartridge

    SteriPure PES Cartridge Filter

    FluorPure PTFE Cartridge Filter

    Melt Blown Cartridge Filter

    Pleated Cartridge Filter

    Ref.MKT2-303

  • MS PolyPure Classic Filters offer economical solutions for a variety of requirements with its excellent filtration efficiency and chemical compatibility across a wide range of liquid process applications. The filter is constructed of pleated polypropylene filter media with high surface area which allows for greater system flow rate. The construction utilizes thermal welding techniques to seal all components and therefore eliminates extracts and optimizing cartridge

    Testing was conducted using the single-pass test method, water

    at 2.6 GPM/10'' cartridge. Contaminants included latex beads,

    coarse and fine test dust. Removal efficiencies were determined

    using dual laser source particle counters.

    Micron ratings from 0.1 to 70 µm– Broad applicationHigh Filtration Efficiency– 90% (Beta 10) Broad chemical compatibility for a wide range of liquid process applications Free of binders, additives and lubricantsFixed pore construction– Eliminates dirt unloading at maximum differential pressureVarious Gasket/O-ring materials– Compatible with many fluids

    MS PolyPure Classic Pleated Cartridge Filter®

    ®

    General water and R.O treatment Industrial chemicals and organic solvents Filtration of alcoholic beverages and soft drinks Filtration of various types of process water, including make-up water

    Description

    Features Filter Removal Efficiency

    Applications

    Beta Ratio

    Efficiency

    Beta 10

    90%

    Beta 5

    80%

    0.22 micron 0.22 0.1

    0.45 micron 0.45 0.22

    1.0 micron 1.0 0.45

    3.0 micron 3.0 2

    5.0 micron 5.0 4

    10.0 micron 10.0 6

    20.0 micron 20.0 15

    30.0 micron 30.0 25

    50.0 micron 50.0 30

    Address: 1108 Spring View Lane Plano, TX 75075 Toll free: 1-866-528-4572 Fax: 1-732-412-4040RD2PD781C4AE7-EN A/1

  • MS PolyPure Classic Pleated Cartridge Filter®

    Specification Filter Pressure Drop vs .Flowrate

    Ordering Information

    Address: 1108 Spring View Lane Plano, TX 75075 Toll free: 1-866-528-4572 Fax: 1-732-412-4040

    Materials of Construction: · Filter Medium: Polypropylene,· Support/Drainage: Polypropylene· Inner Core: Polypropylene· End caps: Polypropylene· Cage: Polypropylene

    Recommended Operating Conditions: · Maximum Operating Temperature: 80℃· Maximum Operating Pressure: 2.4 bar at 20℃· Micron Rating: 0.1μm, 0.22μm, 0.45μm, 1μm, 3μm 5μm,

    10μm, 20μm, 30μm, 50μm, 70μm, 100μm· Recommended Change-Out Differential Pressure: 2.4bar

    Dimensions:· Outside Diameter: 2.7’’ (6.86 cm)· Inner Diameter: 1.3’’ (3.3 cm)· Length: 9.75’’, 10’’, 20’’, 30’’, 40’’

    0 5 10 15 20 25

    0

    10

    20

    30

    40

    Diff

    eren

    tial P

    ress

    ure

    (mba

    r)

    Flow Rate (L/min)

    Test for 10” FilterUnit conversion: 1bar=100kpa

    Flow rate is for a 25.4cm (10inch), cartridge. For liquids other than water,

    multiply differential pressure by fluid viscosity (cP)

    0.22μm0.45μm1.0μm3.0μm5.0μm

    10μm~30μm50μm~100μm

    S= Silicon

    N= NBR

    E= EPDMF=

    P= Teflon Encapsulated Viton

    Viton

    0= DOE

    2= 222/Flat

    3= 222/Fin

    6= 226/Fin

    7= 226/Flat

    Seal MaterialEnd TypeRemoval Ratings

    (μm)Length

    (inch)Filter Media

    PP= Polypropylene 1000= 10μm

    2000= 20μm

    3000= 30μm

    5000= 50μm

    7000= 70μm

    10000= 100μm

    010= 0.1μm

    022= 0.22μm

    045= 0.45μm

    100= 1μm

    300= 3μm

    500= 5μm

    0975= 9.75”

    010= 10”

    020= 20”

    030= 30”

    040= 40”

    CRPP

    RD2PD781C4AE7-EN A/1

    Filtration for Pharmaceutical Applicationlab filtration brochureMembrane Solutions IntroductionMS_filtersPolyPure Filter(1)