Κωνσταντίνος Γαρδίκης, MSc, PhD, Scientific Affairs Director · Extensive...

Έρευνα και ανάπτυξη προϊόντωνΚωνσταντίνος Γαρδίκης, MSc, PhD, Scientific Affairs Director

AP

IVITA

BR

AN

D

APIVITA is a highly sophisticated natural cosmetics brand,

developing and producing natural, effective and holistic

cosmetics and well being products and services

INSP

IRA

TION

S

BEE SOCIETY

GREEK FLORA

HIPPOCRATES

.

OUR DRIVING AXIS

1. Our Brand Identity

2. APIVITA strategic goals on

Raw Materials Development

3. Market research defining

Cosmetics and Health

market status

4. Scientific Collaborations &

Research Programs

5. Cosmetics Legislation

Evolution

6. Innovation

Product Development

Platform … driven by Value

Innovation

WHAT MAKES OUR PRODUCTS UNIQUE

36 YEAR RESEARCH &

DEVELOPMENT

EVOLUTION

Certifications

Scientific collaboration with universities and

research institutes for extensive research on

Greek plant actives and applications

7 research programs in collaboration with the

University of Athens accomplished and 10 in progress

In house plant extracts and oils development

and production

60 plants studied / 200 extracts developed since

1979

37 years proven experience in natural products

development

Experience and flexibility leads to more than 100

new product developments every year Extensive

knowledge of natural and organic cosmetics (the first

in the Greek market to produce natural cosmetics,

the first in the Greek pharmacies to produce organic

sunscreens).

Extensive ingredients testing and deep under-

standing

5000 ingredients tested / 1500 ingredients used.

New developments in increasing products natural

ingredients level such as innovative preservation

systems, emulsifying systems, active ingredients.

The department consists of 14 scientists, chemists, pharmacists, chemical engineers

and cosmetologists who are in charge of the development of natural raw materials,

cosmetic products’ formula and notification & legalization of the products to the

countries of company’s operation

A success story of innovation

PRODUCT

NATURAL – EFFECTIVE - HOLISTIC

NA

TUR

AL

APIVITA products have formulas with high percentage of

natural ingredients 85%-100% , environmentally friendly

packaging and they are produced with respect to nature.

WITH

WITHOUT

NATURAL

Plant extracts

Plant oils

Plant Infusions

Bee Products

Essential oils

*Greek plant, organically cultivated, Hippocrates plants

Parabens

Silicones

Propylene Glycol

Mineral Oil

Ethanolamines

Phthalates, Nitromusks,

Polycyclic Musks

PLANT EXTRACTS

Organic Plants: 99% of the plants we

use for the in house production of

extracts are from organically certified

cultivations

Greek Plants: Combining the

knowledge of the traditional use and

modern scientific research on the

Greek biodiversity

Hippocrates Plants: Thorough study of

his literature brought to light the exact

plant species which he used for his

therapeutic methods.

Hippocrates

Botanical

Garden on

Kos island

EFFEC

TIVE

APIVITA’s R&D department has a proven track record of

experience in developing effective cosmetics.

The ingredients used are on the cutting edge of green

cosmetology and fulfills efficacy substantiation

requirements

Ingredients' activity and effectiveness is measured in

house and in collaborations

In vivo clinical studies are conducted on the final

products in close partnership with research institutes and

universities.

Analytical tests

Physicochemical tests(pH, Specific gravity etc)

UV-Visspectrophotometry

Microbiological tests

Chromatographicanalysis

(HPTLC, HPLC)

Qualitativeanalysis

Quantitative analysis

Total phenolics(Folin- Ciocalteau method)

Total Flavonoids

Radical Scavenging (DPPH)

Total Phenolics

PROOF OF EFFICACYPhytochemistry Lab

http://www.google.gr/url?sa=i&source=images&cd=&cad=rja&docid=PmCYKI8vc35bGM&tbnid=LvcKE7ol8PZvNM:&ved=0CAgQjRw4Lw&url=http://www.sorbtech.com/wordpress/2010/10/getting-resolution-scaling-up-from-tlc-to-column-with-tight-rf-values/&ei=3OPYUsLaJJCjhgeft4CoCw&psig=AFQjCNGmrMOHyVAtoECUEXtuzvl6HGhkig&ust=1390032220664622http://www.google.gr/url?sa=i&source=images&cd=&cad=rja&docid=9z6sz9Tk8rR8oM&tbnid=yRbHd81yICTiNM:&ved=0CAgQjRw4Eg&url=http://ebm.sagepub.com/content/231/8/1287/F1.expansion&ei=m-PYUtP0E8uThQf3roHoAg&psig=AFQjCNHWYVHAgcB3YBkADKieMt5uWlbTuQ&ust=1390032155392294

Biochemistry assays

Gel Electrophoresis

DNA barcoding

Gene expression

Allergen identification

Genetic fingerprinting

Microbiological testing

Real Time Polymerase Chain Reaction (qPCR)

Elisa Immunosorbent

Assay Protein detection

PROOF OF EFFICACYBiochemistry Lab

http://www.google.gr/url?sa=i&source=images&cd=&cad=rja&docid=vUnCrpeYfJqV5M&tbnid=Dw857RLkiJitnM:&ved=0CAgQjRw4EA&url=http://en.wikipedia.org/wiki/Retinoblastoma_protein&ei=7R_YUuWILMeVhQe2v4Ag&psig=AFQjCNFWNCoPzN8oSiJoLoIFiXcgTdPHbQ&ust=1389982061878539http://www.google.gr/url?sa=i&source=images&cd=&cad=rja&docid=e2PYxJGsnaiuoM&tbnid=VxjeFheRF0-I0M:&ved=0CAgQjRw&url=http://en.wikipedia.org/wiki/Gel_electrophoresis_of_nucleic_acids&ei=4KLfUtmpHYbrywPmwICQAw&psig=AFQjCNH6LbNN5_tAscyuj6kGnSy6pSbvgg&ust=1390474336581486http://www.google.gr/url?sa=i&source=images&cd=&cad=rja&docid=iQtruCUmtehzfM&tbnid=7gHNuJAoUGfi9M:&ved=0CAgQjRw&url=http://www.sigmaaldrich.com/life-science/molecular-biology/automation/automation-products/quantitative-pcr.html&ei=9qLfUrqkCuqEyAOc1oDwCg&psig=AFQjCNH7IMNSxTvMbNmUCbPXSwq36AOlMA&ust=1390474358345348http://www.google.gr/url?sa=i&source=images&cd=&cad=rja&docid=9vB4SU62wv0D8M&tbnid=UgbnWQqdNWKLoM:&ved=0CAgQjRw47QE&url=http://www.biologyreference.com/Dn-Ep/Electrophoresis.html&ei=Wh_YUu3SLZKjhgfykYDgDQ&psig=AFQjCNEYm9R4AswwjDPyjK3JA9EWs3LDAg&ust=1389981914828401

Extracellular Molecules

Transcription Regulators

Cell growthand

Proliferation

Apoptosis

Response to Stress

Ageing

Oxidative Stress

Hydration

Inflammation

200 API - Genes

PROOF OF EFFICACYGene Database

Results

• Skin moisturization is improved by 18% after the

first application and by 21%, after 28 days

• 24 h , Skin moisturization

• TEWL is decreased by 18% after 28 days

• Skin elasticity is improved by 16% after 28 days

Results

• Skin’s density was improved at 87% of the

volunteers after 46 days

• Skin’s tone was improved at 97% of the volunteers

after 46 days

• Skin’s texture was improved at 90% of the

volunteers after 46 days

PROOF OF EFFICACYIn-vivo tests

HO

LISTIC

HOLISTIC INSPIRED BY HIPPOCRATES

Multifunctional products which offer more than one

action & cover all skin's needs. Maintain skin’s health

and beauty.

Formulas enriched with 100% pure organic essential

oils in order to enhance a feeling of well being

Holistic approach on health and beauty based on

Hippocrates Philosophy

The teaching of Hippocrates on Experience,

Methodology,Discipline and Evidence is a key

inspiration on new product development

INGREDIENTS

NATURAL – EFFECTIVE - HOLISTIC

PLANT INFUSIONS

Replacing water with herbs infusions to

enhance effectiveness

Greek Wild rose Infusion

Antioxidantanti-aging

action

Rosemary water

Toning

action

Calendula(marigold) water

Calmingand

soothingaction

action

Chamomile water

Anti-irritantand

soothing

action

MountainTea infusion

INNOVATION

http://en.wikipedia.org/wiki/File:Divlja_ruza_cvijet_270508.jpg

• Total phenolic content is assessed by Folin-Ciocalteau assay

• The ability of the infusion to scavenge free radicals is measured by DPPH method

EFFECTIVE

PLANT INFUSIONS

Effectiveness of herb infusions is measured by scientific methods

0

0,05

0,1

0,15

0,2

Sideritisscardica

Sideritisraeseri Sideritis

perfoliataSideritis

blend Green tea

Tro

lox

equ

ival

ent

Antioxidant activity

Sideritis scardica/raeseri/perfoliata

(PATENT USE)

SIDERITIS INFUSION PATENT

Propolis

(PATENT METHOD)

SOPHISTICATED

SKIN DELIVERY SYSTEMS :

Propolis Encapsulation In

Cyclodextrins

EFFECTIVE BEE PRODUCTS

A patent of innovative extraction

method and simultaneous

encapsulation in cyclodextrins

8 In Vitro Studies

1. Cell Viability Protection- UV

treatment

2. Cell Viability Protection –

Heavy metal treatment

3. Cell Metabolism Protection –

UV Treatment

4. Cell Metabolism Protection –


5. Cell antioxidant capability- UV

treatment

6. Cell antioxidant capability –


7. Collagen synthesis

8. Elastin Synthesis

SOPHISTICATED

SKIN DELIVERY SYSTEMS : Propolis

Encapsulation In Cyclodextrins


Benefits of a liposomal formulation

Royal Jelly forms in presence of soy

lecithin (phospholipids) vesicles,

the liposomes

The active ingredients

of Royal Jelly are incorporated

either in the core of the vesicle or

integrated in the phospholipid

bilayer

SOPHISTICATED ‘

SKIN DELIVERY SYSTEMS : Fresh Greek Royal Jelly in

Liposomes


http://upload.wikimedia.org/wikipedia/commons/8/89/Weiselzellen_68a.jpghttp://www.google.gr/url?sa=i&source=images&cd=&cad=rja&docid=gw7r4GYsXjZR9M&tbnid=3jYdmUSth8QBxM:&ved=0CAgQjRwwAA&url=http://www.lyposphericnutrients.co.uk/reasearchanddevelopment.aspx&ei=WPa6UZazAYSmO6P7gBA&psig=AFQjCNEfMH0r6KwEJeLF5elVO5uBtiYkiw&ust=1371293656059992

in-vivo Clinical studies

Increase of skin firmness skin in 90% of volunteers

Increase of skin elasticity in 90% of volunteers

Reducing the depth of wrinkles in 85% of volunteers

Growth stimulation of fibroblasts

SOPHISTICATED

SKIN DELIVERY SYSTEMS : Fresh Greek Royal Jelly in Liposomes


RESEARCH

PROGRAMS NATURAL – EFFECTIVE - HOLISTIC

HORIZON 2020 PROGRAMS

28

1st round: 16.000 proposals1st stage success: 11%2nd stage success: 16%

http://www.google.gr/url?sa=i&source=images&cd=&cad=rja&uact=8&ved=0CAgQjRw4Gw&url=http://www.kowi.de/en/desktopdefault.aspx/tabid-452/1360_read-2481/&ei=k3KZVK_DH4uxaZvOgvAP&psig=AFQjCNFU5kZrqYAvJ-He8m2A0_9QTpWHqQ&ust=1419428883580572

HORIZON 2020: MARISURF

Title: Novel, sustainable marine bio-surfactant / bio-emulsifiers for commercial exploitation

• Call: H2020- Blue Growth--‐3--‐2014• Topic: : Novel marine derived biomolecules and industrial biomaterials• Type of action: Research and Innovation actions

• Target: Isolation and production of new bio-surfactants and bio-emulsifiers by environmental pollution degrading bacteria (green biotechnology and sustainability)

• APIVITA interest: Cosmeceutical formulation / green marketing• Total Budget: 4750000 euro• APIVITA budget: 198000 euro• Reimbursement rate: 100%• Duration: 60 months• Start date: 9/2015

29

PARTICIPANTS

30

PARTICIPANT NO PARTICIPANT ORGANIZATION NAME COUNTRY

1 (Coordinator) HERIOT WATT UNIVERSITY UK

2 ULSTER UNIVERSITY UK

3 UNIVERSITY OF PATRAS GREECE

4 DEMOCRITUS UNIVERSITY OF THRACE GREECE

5 APIVITA, S.A. GREECE

6 BIO BASE EUROPE PILOT PLANT BELGIUM

7 ECOVER BELGIUM

8 ACONDICIONAMIENTO TARRASSENSE SPAIN

9 NOVA INSTITU Gmbh GERMANY

10 NANOIMMUNOTECH, S.L. SPAIN

11 ETS ITALY

12 MARLOW FOODS UK

13 MACHPIE UK

HORIZON 2020: TASCMAR

Title: Tools And Strategies to access to original bioactive compounds from Cultivation of MARine invertebrates and

associated symbionts

• Call: H2020- Blue Growth--‐3--‐2014• Topic: Novel marine derived biomolecules and industrial biomaterials• Type of action: Research and Innovation actions

• Target: Isolation and production of new antioxidant molecules or enhanced extracts from invertebrates

• APIVITA interest: New sustainable and effective raw materials derived with innovative green methods of extraction

• Total Budget: 6760000 euro• APIVITA budget: 400000 euro• Reimbursement rate: 100%• Duration: 48 months• Start date: 4/2015 31

PARTICIPANTS

32

HORIZON 2020: ALGAE4A-B

Title: Development of Microalgae-based novel high added-value products for the Cosmetic and Aquaculture industry

• Call: H2020-MSCA-RISE-2015

• Topic: MSCA-RISE• Type of action: Marie-Curie actions

• Target: New -omic technologies and new strains for the production of high added value cosmeceuticals

• APIVITA interest: New multifunctional enhanced extracts and isolated enzymes

• Total Budget: 972000 euro• APIVITA budget: 216000 euro• Reimbursement rate: 100%• Duration: 48 months• Start date: 11/2015 33

PARTICIPANTS

34

PARTICIPANT

NO

PARTICIPANT ORGANIZATION NAME COUNTRY

1 (Coordinator) FITOPLANCTON MARINO SPAIN

2 APIVITA GREECE

3 CNRS FRANCE

4 AGRICULTURAL UNIVERSITY OF ATHENS GREECE

5 IFAPA SPAIN

6 CCMAR PORTUGAL

7 LIFESEQUENCING SPAIN

http://www.google.gr/url?sa=i&source=imgres&cd=&cad=rja&uact=8&ved=0CAkQjRwwAGoVChMIrMvo_OK_xwIVS5QsCh2rzAHF&url=http://www.ccmar.ualg.pt/index.php?id=838&ei=uQjaVeyKBcuosgGrmYeoDA&psig=AFQjCNG5AdFqLg87n9aSTEHopyVct7zBpg&ust=1440438841177838https://www.google.gr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRxqFQoTCLah94Piv8cCFYd_GgodQT8DmA&url=https://el.wikipedia.org/wiki/%CE%93%CE%B5%CF%89%CF%80%CE%BF%CE%BD%CE%B9%CE%BA%CF%8C_%CE%A0%CE%B1%CE%BD%CE%B5%CF%80%CE%B9%CF%83%CF%84%CE%AE%CE%BC%CE%B9%CE%BF_%CE%91%CE%B8%CE%B7%CE%BD%CF%8E%CE%BD&ei=uwfaVfbXIof_acH-jMAJ&psig=AFQjCNEZ32k9zqu8Qjen7MhkjhDHkJL0dw&ust=1440438582005476http://www.easyalgae.com/index_ingles.asphttp://www.google.gr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRxqFQoTCPeZk-jiv8cCFYpZGgodurAI7Q&url=http://lourdesdiezfajardo.com/nueva-convocatoria-de-empleo-en-el-ifapa/&ei=jQjaVbefLYqzabrhougO&psig=AFQjCNFj1U36Cl7BNf-JtSDC3FeO6t_LPg&ust=1440438783610768http://www.google.gr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRxqFQoTCP7A26rjv8cCFcgEGgod5YwI4w&url=http://mscbioinformatics.uab.cat/base/base3.asp?sitio=msbioinformaticsen&anar=redemp&ei=GQnaVb7QFMiJaOWZopgO&psig=AFQjCNGOKwY8ks8NKHBrlwHNuPGf1SIlaw&ust=1440438932298776http://www.google.gr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRxqFQoTCP7A26rjv8cCFcgEGgod5YwI4w&url=http://mscbioinformatics.uab.cat/base/base3.asp?sitio=msbioinformaticsen&anar=redemp&ei=GQnaVb7QFMiJaOWZopgO&psig=AFQjCNGOKwY8ks8NKHBrlwHNuPGf1SIlaw&ust=1440438932298776

FRAMEWORK 7/GREEK FRAMEWORK PROGRAMS

Exploitation of microalgae diversity for the development of novel high added-value cosmeceuticals

AlgaeCom

http://www.easyalgae.com/index_ingles.asp

Agricultural University of

Athens(AUA)

Participant

Participants

Centre National de Recherches

Scientifique (CNRS)

APIVITA S.A.

FITOPLANCTON MARINO

Greece

Country

France

Greece

Spain

Dept. Agric. Biotechn.

Lab.Molec. Biology

Dept.

Marine plant and

biomolecules

Scientific Affairs-R&D

Dr. EmmanouilFlemetakis

Scientist in charge

Dr. WilliamHelbert

Dr. Konstantinos

Gardikis

Dr. Carlos

Unamunzaga

3

4

2

1

Molecular Biology &

Manufacturing

ALGAECOM-TARGET

Extract(s) with important firming/antiageing properties1

•Setup of biochemistry lab•APIGENES library development•Control/proof of effectiveness•DNA barcoding

2

Contact with a new world of ingredients3

Incorporation in products 2017

Βudget: 1,570,928.00 euro

Nannochloropsis gaditana extract (1st time in cosmetics) +

Propolis patent

PRO-ALGAE PATENT

Bee-based natural products as potential cosmeceutical agents with health promoting properties against UV-induced skin

photo-ageing

BeeCosmAge

APIVITA S.A

Participants

Participants

University of Ioannina (UoI

Democritus University of Thrace

(DuTh)

Greece

Country

Greece

Greece

Depart.Research &

Development

Dept.

Pathologic Anatomy

Molecular Pharmacology

Dr. Konstantinos

Gardikis

Scientist in charge

Dr. Anna Gousia

Dr. Aglaia Pappa

2

1

University of Athens (UoA)

Greece PharmacognosyDr.

Nektarios Aligiannis

Nanchang University (NCU) China

Food Science & Technology

Dr. Liping Luo

3

4

5

Pharmacognosy

•Proof of the uniqueness of Greek bee products

BeeCosmAge-Target

•New series of innovative extracts

•Contact with Chinese academia & market

Βudget: 500,000.00 euro (Greek side)

BeeCosmAge-Dissemination

•European Biotechnology Congress (May 2015, Bucharest)


TOXICITY PROFILING OF PROPOLIS EXTRACTS FROM DIFFERENT GEOGRAPHIC REGIONS OF GREECE AND EVALUATION OF THEIR ANTI-OXIDANT AND ANTI-MUTAGENIC AND ANTI-AGEING PROPERTIES ON HUMAN KERATINOCYTES UNDER UVR EXPOSURE CONDITIONS

Voulgaridou Georgia-Persephoni1,2, Alexis Galanis1, Sofia Eftaxia2, Anna Gousia2, Nektarios Aligiannis3, Kostantinos Gardikis4, Panayiotidis Michalis4 and Pappa Aglaia 1*

1Department of Molecular Biology & Genetics, Democritus University of Thrace, Alexandroupolis,Greece2Department of Pathology Medical School, University of Ioannina, 45110 Ioannina3Department of Pharmacy, Division of Pharmacognosy & Natural Products Chemistry, University of Athens Athens, 157714APIVITA SA, Industrial Park, Markopoulo Mesogaias 19003, Markopoulo Attiki, Athens 5School of Life Sciences, Heriot Watt University, Edinburgh, Scotland*Correspondance: [email protected]

http://www.google.gr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http://srilankanscientist.com/event/european-biotechnology-congress-2015/&ei=EnhbVaD-IMmnsAGIw4GYCw&bvm=bv.93564037,d.bGg&psig=AFQjCNFlxNmfPiltP0v-HpNu-7QmXZIuRg&ust=1432144267702444

•Polyphenols (June 2015, Malta)


APPLICATION OF GREEN EXTRACTION METHODOLOGIES TO DEVELOP PROPOLIS-BASED

NATURAL EXTRACTS AS POTENTIAL COSMECEUTCAL AGENTS

STAVROPOULOU M.-I. (1), STATHOPOULOU K. (1), KANAKIS H. (1), GARDIKIS K. (2), ALIGIANNIS N. (1)

(1) Department of Parmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of

Athens, Athens 15771,Greece

(2) Apivita SA Industrial Park of Markopoulo Mesogaias,19003 Markopoulo Attiki ,Athens ,Greece

Propolis is a resinous material collected by honeybees and has various biological activities (antibacterial, antiviral etc.)[1]. It contains

phenolics [2], widely recognized as strong antioxidants and suggest that propolis could be applied topically to prevent and treat skin damages [3].

Moreover, safety hazards, high cost of organic solvents and the increased concern for environmental pollution, led to green technologies and

innovative extraction procedures [4-6]. This project aims to develop high-quality cosmeceutical agents, based on Greek propolis involving

environmentally friendly techniques.

Controlled Release Propolis

(PATENT METHOD)

PROPOLIS PATENT CONTROLLED RELEASE

Cyclodextrin propolis

Aqueous core

Propolis

Polar head

Physicochemical and biological characterization and improvement of natural muds to produce high added-value

products

PharmaMuds

http://www.google.gr/url?sa=i&rct=j&q=&esrc=s&frm=1&source=images&cd=&cad=rja&uact=8&docid=QAHymLYt2wfesM&tbnid=q8buM2Pshk2hVM:&ved=0CAUQjRw&url=http://www.annalotan.com/&ei=_sCVU5WeDcitO8KvgLgD&bvm=bv.68445247,d.bGQ&psig=AFQjCNGK6OTG4apYkScVlcafNx4WTQatzQ&ust=1402409593722540

APIVITA S.A

Participants

Participants

University of Patras (UPatras)

University of Athens(UoA)

Greece

Country

Greece

Greece

Scientific Affairs-R&D

Dept.

ChemicalEngineering

Medical School/Biological

Chemistry

Dr. Konstantinos

Gardikis

Scientist in charge

Dr. Ioannis Tsamopoulos

Dr. Paraskevi

Moutsatsou

2

1

Technion University (Tech)

IsraelChemical

EngineeringDr.

Avi Nir

Anna Lotan (AL) Israel R&DDr.

Liping Luo

3

4

5

•Stable raw materials

PhatmaMuds-Target

•New face masks

•Proof of the efficacy of traditionally used materials

Incorporation in products 2018

Βudget: 300,000.00 euro (Greek side)

Stabilized Messologi Mud

(PATENT FORMULATION/USE)

STABILIZED MUD PATENT

APIVITA SCIENTIFIC SYNERGIES ECOSYSTEM

74 Universities and Research Institutes 23 countries16 million euro total budget

Our global presenceSince 1979

Our global presence

USA

Cyprus

Japan

SpainGreece

Romania

Benelux

UK

Croatia

Ukraine

Bulgaria

14 COUNTRIES

Hong

Kong

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APIVITA Experience Store

Athens International Airport Store

http://www.google.gr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http://espaergasia.gr/?p=14625&ei=H6k4VbG5BMniarWFgPAL&bvm=bv.91427555,d.bGg&psig=AFQjCNG6vDF6iCAmfM8hfqheXGivLy-K3Q&ust=1429863070057548

Athens Shop in Shop


Athens Pharmacy corner


INNOVATION

extracton of Greek Propolis for the productonof high valued raw material with ant-oxidant and

photo-protectve and ant-aging actvityactvity. a

method with minimum energy consumpton and zerowaste

in order to increase stability, permeability and bio-availability of actve componentsGreek Royal Jelly encapsulaton in liposomes offersnew and enhanced propertes for an-tageing

SPAIN: APIVITA SPAIN S.A.

APIVITA entered the Spanish market in 2003, initially operating

through a distribution agreement

In November 2009, APIVITA established a wholly owned subsidiary

Products are currently placed in:

1 flagship store in Madrid open since March 2010

87 EI Corte Ingles department stores

870 pharmacies

5 Hotel & SPA

Key highlights

SPAIN 1 Store 87 El Corte Ingles 870 Pharmacies


Madrid Flagship Store


El Corte Ingles, Barcelona

INNOVATION





JAPAN: APIVITA JAPAN

APIVITA entered the market in 2010, initially operated through a distribution

agreement

In November 2013, APIVITA established a wholly owned subsidiary. Currently,

since 2015, in joint venture


10 stores in key departments stores

Key highlights

Tokyo Flagship Store Jiyugaoka

INNOVATION





HONG KONG

Apivita is the market for 10 years

Partnership with IMAGINEX, a leading

brand management and distribution

company on the luxury market

segment of the Great China region,

based in Hong Kong

11 shop in shop in key departments

stores

Raised market awareness through key

advertising campaigns

Key highlights

NEW TOWN PLAZA Shatin


INNOVATION





Romania

APIVITA is in the market for 6 years

Partnership with SensiBlu

SensiBlu owns 80% of the pharmacy channel in Romania


405 pharmacies - 320 full brand

1 flagship store

2 shop in shop

Key highlights

ROMANIA 405 Pharmacies (53 corners)

Romania Pharmacy Corner

ROMANIA New Store Bucharest

INNOVATION





Cyprus


Partnership with Drogopharma


250 pharmacies

1 experience store open since October 2015

Key highlights

CYPRUS New Experience Store

CYPRUS International Airport

CYPRUS Pharmacy Corner

INNOVATION





Benelux

Present since July 2010


Belgium (100+ pharmacies)

Luxembourg

The Netherlands ( 1 Apivita store open since November 2015)

Key highlights

The NETHERLANDS New Amsterdam

Store

BELGIUM 100 Pharmacies

INNOVATION





Ukraine


Partnership with Olfa


• 250 pharmacies

• 2 Apivita stores

Key highlights

UKRAINE 250 Pharmacies

INNOVATION





Bulgaria


Partnership with A&D Pharma


• 60 pharmacies

• Notos Department Stores

Key highlights

Six Senses Spa -

Elounda,

Greece

HOTEL & SPA

Six Senses Spa -

Turkey

Me by MELIÁ,

Madrid

Thank you

Κωνσταντίνος Γαρδίκης, MSc, PhD, Scientific Affairs Director · Extensive...

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