entofus EMERGING THREAT REPORT U2017 Annual … 4-Methylenedioxy-α-PBP MMMP. 8 7 1 5-EAPB 5-MAPB...

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EMERGING THREAT REPORT 2017 Drug Enforcement Administra�on Special Testing and Research Laboratory U S D e p a rt m e n t o f . . J u s tic e D ru g E nfo rc e m e nt A dm in ist r a t i o n . Annual FOR OFFICIAL USE ONLY CATHINONES The Special Tes�ng and Research Laboratory’s Emerging Trends Program compiled the data for this report through a query of archived seizure and analysis informa�on from drug evidence analyzed by the Drug Enforcement Administra�on’ s laboratory system. This data is representa�ve of drug evidence seized and analyzed in the date ranges annotated. This is not a comprehensive list of all new psychoac�ve substances and is not representative of all evidence analyzed by DEA. This data is an annual snapshot of the new psychoactive substance market in the United States. The term new psychoactive substance (NPS) describes a recently emerged drug that may pose a public health threat. This includes synthetic cannabinoids, substituted cathinones, phenethylamines, opioids, tryptamines, benzodiazepines, and a variety of other chemical classes. Due to the ongoing increase in seizures, fentanyl and related compounds are also included in this report. Summary NPS, excluding fentanyl and fentanyl-related compounds, accounted for approximately 4% of the exhibits seized in 2017 and analyzed by the DEA laboratory system in 2017. FUB-AMB was the most reported synthe�c cannabinoid and N-ethylpentylone was the most reported cathinone in 2017. Fentanyl and fentanyl-related compounds represented approximately 7% of the exhibits seized in 2017 and analyzed by the DEA laboratory system in 2017. Fentanyl and furanyl fentanyl were the most commonly reported opioids. There were 15 substances reported for the first �me in CY2017, meaning they have not been encountered for at least the last three years. This equates to one new substance every three weeks. It should be noted that as backlogged samples are analyzed, the date of the first encounter may change. Most notably, approximately 55% of the opioids iden�fied in CY2017 were seized and iden�fied for the first �me in CY2017. There was a significant increase in the number of NPS benzodiazepines reported in CY2017. The most prevalent NPS benzodiazepine in CY2017 was e�zolam. N-Ethylpentylone was the most reported cathinone, accoun�ng for approximately 54% of the iden�fica�ons during the repor�ng period. Of the 19 substances iden�fied, α-PPP and MMMP were iden�fied for the first �me in 2017. OPIOIDS/ ANALGESICS An iden�fica�on is made when authen�cated reference material is available for comparison. When reference material is not available, the drug evidence is iden�fied as “substance unconfirmed.” A single unit of drug evidence may have mul�ple sub-units. For the purposes of this document, each unit of drug evidence counts as one iden�fica�on regardless of the number of sub-units. Some seized drug evidence contains more than one ac�ve ingredient; therefore, more than one iden�fica�on can be made for a single unit. There were 369 cathinone iden�fica�ons in CY2017. 1873 284 186 81 74 70 59 50 49 43 25 10 6 5 1 1 4 4 Fentanyl Furanyl fentanyl U-47700 THF Fentanyl U-49900 Benzylfentanyl There were 2825 iden�fica�ons of fentanyl, fentanyl-related compounds, and other new synthe�c opioids. This accounts for an approximately 117% increase in iden�fica�ons from 2016. Fentanyl accounted for approximately 66% of the iden�fica�ons. The next most prominent synthe�c opioid, furanyl fentanyl, accounted for 10% of the iden�fica�ons. Of the 1873 fentanyl idenfica ons, fentanyl was found as the only controlled substance in ~43% oftheidentifications and was found with heroin in ~47% o f the iden fica ons. Other controlled substances seen with fentanyl include heroin, methamphetamine, cocaine, other fentanyl-related compounds, U-47700, 4- ANPP, tramadol, and synthec cannabinoids. The following synthe c opioids were seized and iden fied for the first me in CY2017: methoxyacetylfentanyl, THF fentanyl, cyclopropylfentanyl, U-49900, benzoylbenzyl fentanyl, acryl fentanyl, 4- fluoroisobutyryl fentanyl, U-48800, 2-thiofuranyl fentanyl, and benzoylbenzyl fentanyl. 201 64 21 20 17 14 7 6 3 3 3 2 2 1 1 1 1 1 1 N-Ethylpentylone Dibutylone 4-CEC α-PVP Pentylone Ethylone α-PHP TH-PVP 4Cl-α-PVP 4-MMC 4Cl-α-PPP 4F-α-PHP N-Ethylbuphedrone Benzoylbenzyl fentanyl 4-ANPP 4-FiBF Carfentanil Acetylfentanyl Cyclopropylfentanyl Methoxyacetylfentanyl Acryl fentanyl 3-Methylfentanyl Butyryl fentanyl 2-Thiofuranyl fentanyl U-48800 MMMP = Methylmethylthiophenyl- morpholinopropanone PBP = Pyrrolidinobutiophenone MMC = Methylmethcathionone PPP = Pyrrolidinopropiophenone CMC = Chloromethcathinone MeAPP = Methylethylaminopentiophenone PHP = Pyrrolidinohexanophenone PVP = Pyrrolidinovalerophenone CEC = Chloroethcathinone 4-MeAPP 4-CMC α-PPP Methylone 4-Methylenedioxy-α-PBP MMMP

Transcript of entofus EMERGING THREAT REPORT U2017 Annual … 4-Methylenedioxy-α-PBP MMMP. 8 7 1 5-EAPB 5-MAPB...

EMERGING THREAT REPORT 2017 Drug Enforcement Administra�onSpecial Testing and Research Laboratory

US Department of. . Justice

Drug Enforcement Admini

stra

tion

.

Annual

FOR OFFICIAL USE ONLY

CATHINONES

The Special Tes�ng and Research Laboratory’s Emerging Trends Program compiled the data for this report through a query of archived seizure and analysis informa�on from drug evidence analyzed by the Drug Enforcement Administra�on’s laboratory system. This data is representa�ve of drug evidence seized and analyzed in the date ranges annotated. This is not a comprehensive list of all new psychoac�ve substances and is not representative of all evidence analyzed by DEA. This data is an annual snapshot of the new psychoactive substance market in the United States.

The term new psychoactive substance (NPS) describes a recently emerged drug that may pose a public health threat. This includes synthetic cannabinoids, substituted cathinones, phenethylamines, opioids, tryptamines, benzodiazepines, and a variety of other chemical classes. Due to the ongoing increase in seizures, fentanyl and related compounds are also included in this report.

Summary

NPS, excluding fentanyl and fentanyl-related compounds, accounted for approximately 4% of the exhibits seized in 2017 and analyzed by the DEA laboratory system in 2017.

FUB-AMB was the most reported synthe�c cannabinoid and N-ethylpentylone was the most reported cathinone in 2017.

Fentanyl and fentanyl-related compounds represented approximately 7% of the exhibits seized in 2017 and analyzed by the DEA laboratory system in 2017.

Fentanyl and furanyl fentanyl were the most commonly reported opioids.

There were 15 substances reported for the first �me in CY2017, meaning they have not been encountered for at least the last three years. This equates to one new substance every three weeks. It should be noted that as backlogged samples are analyzed, the date of the first encounter may change.

Most notably, approximately 55% of the opioids iden�fied in CY2017 were seized and iden�fied for the first �me in CY2017.

There was a significant increase in the number of NPS benzodiazepines reported in CY2017. The most prevalent NPS benzodiazepine in CY2017 was e�zolam.

N-Ethylpentylone was the most reported cathinone, accoun�ng for

approximately 54% of the iden�fica�ons during the repor�ng

period. Of the 19 substances iden�fied, α-PPP and MMMP were iden�fied for the first �me in 2017.

OPIOIDS/ANALGESICS

An iden�fica�on is made when authen�cated reference material is available for comparison. When reference material is not available, the drug evidence is iden�fied as “substance unconfirmed.” A single unit of drug evidence may have mul�ple sub-units. For the purposes of this document, each unit of drug evidence counts as one iden�fica�on regardless of the number of sub-units. Some seized drug evidence contains more than one ac�ve ingredient; therefore, more than one iden�fica�on can be made for a single unit.

There were 369 cathinone iden�fica�ons in CY2017.

1873

284186

81747059504943

2510

65

1144

FentanylFuranyl fentanyl

U-47700

THF FentanylU-49900

Benzylfentanyl

There were 2825 iden�fica�ons of fentanyl, fentanyl-related compounds,

and other new synthe�c opioids. This accounts for an approximately 117% increase in iden�fica�ons from 2016. Fentanyl accounted for approximately

66% of the iden�fica�ons. The next most prominent synthe�c opioid, furanyl

fentanyl, accounted for 10% of the iden�fica�ons.

Of the 1873 fentanyl iden�fica�ons, fentanyl was found as the only controlled

substance in ~43% of the identifications and was found with heroin in ~47% of the iden�fica�ons. Other controlled substances seen with fentanyl include heroin, methamphetamine, cocaine, other fentanyl-related compounds, U-47700, 4-ANPP, tramadol, and synthe�c cannabinoids. The following synthe�c opioids were seized and iden�fied for the first �me in CY2017: methoxyacetylfentanyl, THF fentanyl, cyclopropylfentanyl, U-49900, benzoylbenzyl fentanyl, acryl fentanyl, 4-fluoroisobutyryl fentanyl, U-48800, 2-thiofuranyl fentanyl, and benzoylbenzyl fentanyl.

201

6421

20

17

14

7

6

3

3

32

2

1

1

1

11

1

N-Ethylpentylone

Dibutylone

4-CEC

α-PVP

Pentylone

Ethylone

α-PHP

TH-PVP

4Cl-α-PVP

4-MMC

4Cl-α-PPP

4F-α-PHP

N-Ethylbuphedrone

Benzoylbenzyl fentanyl

4-ANPP4-FiBF

CarfentanilAcetylfentanyl

CyclopropylfentanylMethoxyacetylfentanyl

Acryl fentanyl

3-MethylfentanylButyryl fentanyl

2-Thiofuranyl fentanylU-48800

MMMP = Methylmethylthiophenyl-morpholinopropanonePBP = PyrrolidinobutiophenoneMMC = MethylmethcathiononePPP = PyrrolidinopropiophenoneCMC = ChloromethcathinoneMeAPP = MethylethylaminopentiophenonePHP = PyrrolidinohexanophenonePVP = PyrrolidinovalerophenoneCEC = Chloroethcathinone

4-MeAPP

4-CMC

α-PPP

Methylone

4-Methylenedioxy-α-PBP

MMMP

8

7

1

5-EAPB

5-MAPB

6-APBBenzofurans

Piperazines

Benzodiazepines

EMERGING THREAT REPORT 2017 Drug Enforcement Administra�onSpecial Testing and Research Laboratory

US Department of. . Justice

Drug Enforcement Admini

stra

tion

.

Annual (continued)

FOR OFFICIAL USE ONLY

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9

4

3

3

E�zolam

Flubromazepam

Flubromazolam

Diclazepam

Phenazepam

HALLUCINOGENSOTHERSYNTHETIC

CANNABINOIDSThere were 53 instances of unconfirmed substances during the

repor�ng period. This represents an approximately 23% increase in

unconfirmed substances from 2016. There were 5 benzodiazepines,

5 piperazines, and 3 benzofurans reported in CY2017. Addi�onally there

were 17 iden�fica�ons of 3-methoxy-PCP, 10 iden�fica�ons of

mitragynine, 7 iden�fica�ons of 3-fluorophenmetrazine,

7 iden�fica�ons of methoxetamine, 6 iden�fica�ons of

deschloroketamine, 4 iden�fica�ons of DMAA, 3 iden�fica�ons of

2-oxo-PCE, 3 iden�fica�ons of methoxphenidine, and 2iden�fica�ons of 4-fluoroamphetamine. 5-MAPB and 2-oxo-PCE were iden�fied for the first �me during this repor�ng period.

TRYPTAMINES

4-

4-Methyl-N-

7

4

1

1

1

TFMPP

pFPP

MeOPP

BZP

BZP

There were 922 synthe�c cannabinoid iden�fica�ons in CY2017.FUB-AMB was the most reported synthe�c cannabinoid, accoun�ng for approximately 51% of the iden�fica�ons. There

were 21 different synthe�c cannabinoids iden�fied in 2017. This

is a significant decrease from the 37 different substancesiden�fied in 2016.

As a result of the significant increase in NPS benzodiazepine identifications, we will begin reporting these in a designated section of the report in 2018.

Due to the consistently low identification of tryptamines over the last two years, we will be including this class in the “Other” section in future reports.

Questions about this data are welcome and maybe directed to the DEA Emerging Trends Program at 703-668-3300 or [email protected]

There were 4 iden�fica�ons of 25I-NBOMe, 4 iden�fica�ons of DOC, 2 iden�fica�ons of 25C-NBOMe, 2 iden�fica�ons of 2C-B, and 1 iden�fica�on of DOB.

There were 2 iden�fica�ons of 4-OH-MET, 2 iden�fica�ons

of 5-MeO-DMT, 1 iden�fica�on of 4-AcO-DMT, and

1 iden�fica�on of 5-MeO-MiPT. 4-OH-MET was seized and iden�fied for the first �me in CY2017.

PLEASE NOTE:

207

112

470

38

24

12

11

10

8

6

4

4

3

2

2

2

2

1

1

1

1

1

ADB-

MMB-

AB-

5F-UR-

AB-

ADB-

MDMB-

5F-

AB-

FUB-

FUB-

5F-

MDMB-

SDB-

5F-AB-

5F-EMB-

FUB-PB-22

5F-MDMB-PINACA

FUBINACA

CHMICA

FUBINACA

144

CHMINACA

CHMINACA

FUBINACA

AMB

PINACA

AKB48

144

AKB48

CHMICA

NM2201

005

PINACA

PINACA

-22 PB

PX-1

The "other" category includes substances that could not be confirmed, psychoactive plants, PCP-related substances, benzofurans, benzodiazepines, piperizines, and amphetamines.

5F-EMB-PINACA was seized and identified for the first time in 2017.

MAB-CHMINACA = ADB-CHMINACA

FUB-AMB