Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed...

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Electronics Laboratory Director: Prof Costas Balas Electronic and Computer Architecture Division Dept. of Electronic & Computer Engineering Technical University of Crete GR 73100 Chania, Crete, Greece www.electronics.tuc.gr Activity Profile

Transcript of Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed...

Page 1: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Electronics Laboratory Director: Prof Costas Balas

Electronic and Computer Architecture Division

Dept. of Electronic & Computer Engineering

Technical University of Crete

GR 73100 Chania, Crete, Greece

www.electronics.tuc.gr

Activity Profile

Page 2: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Electronics lab

People & Structure

RF-IC design 2003-

Optoelectronics 2002-

Total

Faculty Matthias Bucher Assistant Professor Group leader

Costas Balas Associate Professor Lab director Group leader

2

Post Doctoral Researchers

Dr. Rupendra Sharma (Sept. 2011 – Nov. 2012, FP7 COMON)

1

PhD Students 1.A. Antonopoulos, 2.G. Rozakis, 3.N. Mavredakis 4.M.-A. Chalkiadaki 5.N. Makris

1. G. Papoutsoglou 2. A. Tsapras 7

MSc Students 1.K. Kostopoulos 2.K.Papathanasiou 3.G. Gyroukis

1.V. Kavvadias 2.G. Epitropou 3.D. Iliou 4.C. Katsikani

7

Total 17

2

Diploma Theses

12 10 22

Page 3: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Teaching

Under Graduate Courses

ACE 301: Electronics I (CB, Comp)

ACE 311: Electronics II (MB, Comp)

ACE 414: Optoelectronics (CB, Choice)

ACE 506: Design of CMOS Analog Integrated Circuits (MB, Choice)

ACE 413: Biomedical Engineering (CB)

Post Graduate Courses ACE 604: Special Themes of Analog IC

Design (MB) ACE 614: Optoelectronics (Cross-linked

with ΗΡΥ 414) (CB) ACE 634: Electronic Imaging (CB)

Exams: theory, labs, projects.

Target is to develop a solid theoretical background including both semiconductor physics and circuits

combined with… hands on practice …. for developing, team working and practical problem-solving skills

Digital Notes Created: CB : ACE 301 theory, pages: 150, Labs pages: 40, ACE 414 theory, pages 130, labs MB: ACE 311 theory, pages: 300, Labs pages: 70, ACE 416 theory, pages 120

Students assembling /testing a diode laser driver (ACE 414)

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Page 4: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Invited lectures @ GR student IEEE student branch, Patras 2011 (C.B)

Summer School -EU Eng. Student Association “BEST” (org/hosted by C.B. @ Chania 2011)

M. Bucher (Tutorial), “CMOS Device Modeling for Analog/RF Design”, European Solid-State Circuits Conference (ESSCIRC), Athens, Sept. 2009

National/International

seminars (2010-2011)

National/International

book chapters for graduate ed.

C. Balas, G. Epitropou, C. Pappas: “Multi/Hyper-Spectral Imaging” in Handbook of Biomedical Optics, Taylor&Francis Books, Inc, USA, 2011.

C. Balas and E. Diakomanolis, “New technologies in Colposcopy” in Colposcopy text book, Paschalides Ed. Greece, 2010.

C. Balas et al. “Dynamic Spectral Imaging for the Detection of Cervical Neoplasia” in Cervical Cancer Prevention text book, Studio Press, 2007.

M. Bucher et al., “EKV3.0: An Advanced Charge Based MOS Transistor Model”, in Transistor Level Modeling for Analog/RF IC Design, Springer, 2006.

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Page 5: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

RF Integrated Circuit Design Group

Electronics Laboratory

Dept. of Electronic & Computer Engineering

Technical University of Crete GR 73100 Chania, Crete, Greece

Matthias Bucher Assistant Professor, Electronics Laboratory

+30 28210 37210 Bucher “at” electronics.tuc.gr

www.electronics.tuc.gr, www.ekv3.tuc.gr

Page 6: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

International Technology Roadmap for Semiconductors (ITRS) recognizes COMPACT MODELLING as one of the bottlenecks in the

deployment of new technologies

“Design gap” in particular in analog/RF design: need for highly skilled human resources. need for methodologies in LV, LP, RF design

“Design automation gap”: in analog/RFIC design (vs. digital design)

Design gap exists also in Greece (Microelectronics Industry!)

Main field of research: design of low-voltage/low-power analog/RF integrated circuits

compact modelling in advanced semiconductor technology

Particular field of research: Next gen. nanoscale CMOS: multi-gate transistors (FinFET, DGFET)

high-voltage transistors (HVMOS) – RF, automotive applications e.a.

novel devices (SiC FETs) for high-current applications

Research Activities, Microelectronics Group

A. Environment

6 ΗΛΕΚΤΡΟΝΙΚ

Η Ι

Κωνσταντίνος

Μπάλας

Page 7: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Need for last mile broadband access

With scaling of MOS devices down to the 22nm-regime

Power consumption becomes a stringent demand

Need for low-voltage, low-power circuit design

Microelectronics group

Millimetre-wave circuit design

Design of transceiver components (Low-Noise Amplifiers, Voltage-Controlled Oscillators, Variable-Gain Amplifiers)

MOS device modelling and characterization with EKV3 compact model

Research Activities, Microelectronics Group

Β. Motivation

7 ΗΛΕΚΤΡΟΝΙΚ

Η Ι

Κωνσταντίνος

Μπάλας

General Receiver Architecture

Page 8: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

DC to RF & Noise on-wafer probing

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RF probe station (on-wafer measurements in temperature controlled, shielded environment)

4 micromanipulators, microscope, T-controlled chuck

DC/RF probes contacting a CMOS wafer

RF Network Analyzer up to 26 GHz, Signal

generator, Spectrum analyzer, DC sources etc.

Source=Bulk

Gate Drain

Source=Bulk

Page 9: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

0.00

0.01

0.02

0.03

0.04

0.05

0.06

0.07

0.0 0.2 0.4 0.6 0.8 1.0 1.2

VD [V]

ID [

A]

measured

EKV3.0

f = 300MHz

-100

-90

-80

-70

-60

-50

-40

-30

-20

-10

0

-1.2-1.1-1-0.9-0.8-0.7-0.6-0.5-0.4-0.3-0.2-0.1

VG [V]

Am

plitu

de [

db

m]

Fundamental

EKV3.0

2nd Harmonic

EKV3.0

3rd Harmonic

EKV3.0

DC , RF & noise on-wafer characterization of nano-scale semiconductor devices Microwave characterization (-> 26.5 GHz) Ultra-low currents (~1 pA … 100 mA) LCR (~10pF) Low-frequency Noise (~1 Hz … 100 kHz)

0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

0.9

1

0.001 0.01 0.1 1 10 100 1000

IC = ID / Ispec [-]g

ms *

UT

/ I

D [

-]

10x10

10x2

10x1

10x0.5

10x0.3

10x0.25

10x0.2

10x0.16

10x0.14

10x0.135

10x0.125

0.1

1

10

100

1000

0.001 0.01 0.1 1 10 100 1000

IC = ID / Ispec [-]

VA

= ID

/gd

s [

1/V

]

10x10

10x2

10x1

10x0.5

10x0.3

10x0.25

10x0.2

10x0.16

10x0.14

10x0.135

10x0.125

Transconductance Efficiency

Early Voltage FT

Harmonic Distortion @RF

Research Activities in Microelectronics C. Research projects (i): DC to RF characterization

M. Bucher, A. Bazigos, S. Yoshitomi, N. Itoh, „A Scalable Advanced RF IC Design-Oriented MOSFET Model”, Int. Journal of RF and Microwave Computer Aided Engineering, Vol. 18, N° 4, pp. 314-325, July 2008.

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Process design kits limitations on Frequency up to which MOS devices are

characterized

Page 10: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Design of Analog / RF integrated circuits (RFICs) - Design Flow

Research Activities in Microelectronics

C. Research projects (ii): Analog/RFIC Design

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EUROPRACTICE IC Service, offered by IMEC and Fraunhofer, offers

low-cost ASIC prototyping and ASIC small volume production ramp-up

to high volume production through Multi Project Wafer - MPW - and

dedicated wafer runs.

Page 11: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Design of Analog / RF integrated circuits (RFICs) Design of integrated RF CMOS transceivers Design of low-voltage, low current, low power analog

ICs Ultra-low voltage circuit design techniques

Research Activities in Microelectronics

C. Research projects (ii): Analog/RFIC Design

HERAKLITOS II: Nanoscale RF CMOS Transceiver Design, Ministry of Education, 2010-2013. CORALLIA: NexGenMilliWave, Next Generation Millimeter Wave Backhaul Radio, Hellenic Technology Cluster Initiative in Microelectronics, Duration: 2009 – 2012.

RF LNA @ 30 GHz, 90nm CMOS LV/LP analog design (OTA), 65nm CMOS

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Page 12: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής 12

Research Activities in Microelectronics

C. Research projects (ii): Analog/RFIC Design

Design of Analog / RF integrated circuits (RFICs) TSMC 90nm process 1920 x1920 um 100 dies DC , CV & RF EKV3 modeling and characterization On Wafer Measurements 30 GHz LNA

Page 13: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Development of Computer Aided Design (CAD) Tools EKV3 MOS transistor compact model

Multigate nanotransistor/FinFET compact modelling

High-Voltage MOSFET (LDMOS) compact modelling

Design automation of analog/RF building blocks

Research Activities in Microelectronics

C. Research projects (iii): Development of CAD Tools

Markers: Measurements

Blue Lines: Analytical Expressions

Green Lines: Analytical Expressions with RG=0

L = 70 nm, W = 2 μm, NF = 10

Freq=50MHz…20.5GHz; VGS = 0.8V; VDS = 0.8V; VSB = 0V;

Real (Y12) Real (Y22)

Imag (Y11) Imag (Y12) Imag (Y21) Imag (Y22)

Real (Y11) Real (Y21)

A. Bazigos, F. Krummenacher, J.-M. Sallese, M. Bucher, E. Seebacher, W. Posch, K. Molnar, M. Tang, “A Physics-Based Analytical Compact Model for the Drift Region of the HV-MOSFET”, IEEE Trans. on Electron Devices, Vol. 58, N° 6, pp. 1710-1721, 2011.

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Page 14: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

RFIC Lab Equipment & Software

Equipment • RF Probe Station semi-automatic, thermal probing (-65 oC to +200 oC) • Vector Network Analyzer HP 8510C (26.5 GHz) • RF Signal Generator, Rohde-Schwarz SMJ100A (6 GHz), arb. BB • Real-Time RF Spectrum Analyzer, Tektronix RSA2208A (8 GHz) • Mixed-Signal Oscilloscope, Agilent MSO6104 (1 GHz) • Precision LCR Meter, Agilent E4980A (2 MHz) • Dynamic Signal Analyzer, Agilent 35670A (100 kHz) • DC Semiconductor Parameter Analyzer HP 4142B, HP 4145A • Keithley Semiconductor Characterization System, 4200-SCS Software • Circuit simulation: Cadence IC & Systems, Agilent ADS, Dolphin Smash, Mentor

Graphics ELDO, ngspice • Instrument control, Parameter extraction: Agilent IC-CAP, VEE Pro 8, Cascade

Microtech PCS • TCAD simulation (2D/3D): Minimos, Silvaco Access to Europractice and MOSIS MPW (multi-project wafer) services

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Page 15: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

European Research Projects: FP7 “COMON”, Compact Modelling Network, Contract Nr. 218255, Marie Curie Industry-

Academia Partnership and Pathways (IAPP), 2008-2012. http://www.compactmodelling.eu/ FP6 “TARGET”, Top Amplifier Research in a European Team, Contract Nr. 507893, Network of

Excellence, 2004-2007.

Greek National Projects: HERAKLITOS II: Nanoscale CMOS Transceiver Design, Ministry of Education & Lifelong

Learning, 2010-2013. COOPERATION: NANOsympraxis, Multigate MOSFET nanotransistors: compact models for

current and noise – development of automated design tools for nanoelectronics, Contract Nr. 09-SYN-32-998, Ministry of Education & Lifelong Learning, 2010 – 2013.

COOPERATION: ANTI-SiC, Development of new transistors and inverter for photovoltaic systems based on Silicon Carbide, Contract Nr. 09-SYN-42-1181, Ministry of Education & Lifelong Learning, 2010 – 2013.

CORALLIA: MEMSENSE, MEMS Based Wireless Sensor Networks, Hellenic Technology Cluster Initiative in Microelectronics - Phase 2, 2009 – 2012.

CORALLIA: NexGenMilliWave, Next Generation Millimeter Wave Backhaul Radio, Hellenic Technology Cluster Initiative in Microelectronics - Phase 2, Duration: 2009 – 2012.

AKMON: Greek Ministry of Development, 2006 – 2008. PENED 03ED354: Power Amplifier Design for Metropolitan Wireless Networks Based on

802.16, Ministry of Development, 2006-2009.

Research Programs of the Microelectronics Group

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Page 16: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Direct Industry Relations Toshiba Semiconductor

Infineon Technologies

Intel

austriamicrosystems

Atmel Semiconductor

EM Microelectronic Marin SA

Corallia: Hellenic Technology Cluster Initiative in Microelectronics: www. corallia.org over ~50 companies in Microelectronics in Greece (~350 M€/yr. exports!)

THETA Microelectronics, HELIC, Prisma Electronics, Analogies, RAYCAP, ….

Technology transfer Compact modelling expertise

EKV3 (www.ekv3.tuc.gr) compact model developed (advanced CMOS)

DC to RF characterization

Ultra-low voltage/Low-power & RF design

Research Activities in Microelectronics

C. Technology Transfer/Industrial collaborations

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Page 17: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Collaborations (indicative)

AdMOS

Atmel Semiconductor

Austriamicrosystems

AUTH Thessaloniki

Cadence Design Systems

CEA-LETI

CERN

CSEM

Cypress Semiconductor

Dolphin Integration

EM Microelectronic

EPFL

FORTH-IESL

Helic

Infineon Technologies

Intel

ITE Warsaw

Mentor Graphics

Microchip

RAYCAP

Tektronix

TU-Dresden

THETA Microelectronics

Toshiba Semiconductor

UC Berkeley

UCL Louvain-La Neuve

UNCC Charlotte

Uni Kjeller

Uni Strasbourg

URV Tarragona

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Page 18: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Optoelectronics Group

Electronics Laboratory

Dept. of Electronic & Computer Engineering

Technical University of Crete GR 73100 Chania, Crete, Greece

Costas Balas Associate Professor, electronics lab director and group leader

+30 28210 37212 balas“at” electronics.tuc.gr

www.electronics.tuc.gr

Page 19: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

The European Commission has acknowledged the importance of Photonics by identifying it as a Key Enabling Technology for Europe.

“ Without strong European leadership in photonics technologies, these industries will be left vulnerable to strong competition from the USA and Asia”. (http://www.photonics21.org )

Photonics 21 EU initiative has named 21th century as the "photon century”

“Following the paradigm of the rapid evolution of electronics that followed the invention of the transistor in the late 1940’s, over the coming decades photonics will impact most areas of our lives, revolutionising societies and industries around the globe”.

Main areas of focus: Information and Communication , Life Science and Health, Emerging

Lighting, Electronics and Displays, Security, Metrology and Sensors,

Research Activities in Optoelectronics

A. Environment

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Page 20: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Three quarters of the global health care expenditure is currently spent on the symptomatic treatment of progressed illness.

Biophotonics has enormous potential as a key enabling technology to identify the root cause of diseases rather than easing existing Symptoms

Biophotonics will also greatly accelerate molecular diagnosis, and so constitute a great step towards personalized medicine and a better quality of life.

Our Focus: Life Science and Health (biophotonics)

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Page 21: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Optoelectronics Group

Research areas

Dynamic Contrast Enhanced Molecular Optical Imaging

Hyperspectral Imaging

Scientific Instrumentation

Page 22: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Dynamic Contrast Enhanced Molecular Imaging

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It is based on signal emitting tracers (biomarkers) combined with sophisticated imaging modalities to detect changes at the molecular and genetic level.

Identifies cancer precursors before changes are detected at anatomical levels.

Provides info for understanding the molecular origins of cancer.

It holds the promise to become a sensitive and specific method to detect and prevent the progression of precancerous lesions.

Page 23: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

DCE-OI

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Normalized DDR curves, corresponding to 4

low grade (gray) and 4 high grade (black) cervical

neoplasias confirmed with biopsies.

Page 25: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

I

pH

:H+ :AC

:gap junctions, inactive in CIN

:tight junctions, loose in CIN

:ion buffers

Measuring the biomarker’s uptake kinetics , in vivo…..

copyright Costas Balas 2012

Page 26: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

(a) Epithelial compartments and transport fluxes (b) The two-compartment cell model and transport fluxes

In silico simulation of biomarker uptake kinetics and of biomarker uptake kinetics

1 1 1

1 1 1 1 1

10

HIS

i i i

i i i i

CH AA AAi

IS ES m T

ES

Ac Ac H Hi

ES m m T p

d lnC q b J a K J

dt

w b J a K J a K J J

copyright Costas Balas 2012

Page 27: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Inverse problem formulation and solution

0 50 100 150 200 2500

0.1

0.2

0.3

0.4

0.5

0.6

0.7

time (sec)

No

rmali

zed

Dif

fuse

Refl

ecta

nce (

ND

R)

0 50 100 150 200 2500

0.1

0.2

0.3

0.4

0.5

0.6

0.7

No

rmali

zed

Co

ncen

trati

on

LG - 2

HG - 1

Param

eter LG1 LG2 LG3 LG4 HG1 HG2 HG3 HG4

b (μM) 0.11 0.17 0.30 0.25 0.310 0.28 0.18 0.26

βIS

(mM) 23.0 17.6 19.0 12.7 25.5 32.2 18.6 24.4

layers 3 6 7 7 11 10 9 10

pHES 6.46 6.78 6.91 6.97 6.01 6.03 6.04 6

In silico simulation Global sensitivity analysis

Global optimization/ biological parameter estimation

NRMSD<2%

copyright Costas Balas 2012

Page 28: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Major achievements on DCE-OI • Fist to develop DCE-OI worldwide • Numerous patents, awards, invited talks • Licensed technologies to industry/products in global markets • Costas Balas: Lead Guest Editor of Special Issue on Dynamic Contrast

Enhanced Imaging, International Journal of Biomedical Imaging 2012-2013 selected pubs • "Estimation of Neoplasia-Related Biological Parameters through Modeling

and Sensitivity Analysis of Optical Molecular Imaging Data" • G. Papoutsoglou, C. Balas

IEEE-Transactions on Biomedical Engineering, accepted • C. Balas “ A Novel Optical Imaging Method for the Early Detection,

Quantitative Grading and Mapping of Cancerous and Precancerous lesions of Cervix”, IEEE-Transactions on Biomedical Engineering, vol. 48, No 1, pp. 96-104, 2001

• C. Balas, G. Papoutsoglou, and A. Potirakis, “In vivo molecular imaging of cervical neoplasia using acetic acid as biomarker,” IEEE Journal of Selected Topics in Quantum Electronics, vol. 14, no. 1, pp. 29-42, Jan-Feb, 2008

W. P. Soutter, .., C. Balas. “Dynamic Spectral Imaging-Improving Colposcopy” Clinical Cancer Research 15, 1814, 2009

Page 29: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Hyperspectral Imaging

Developing new cameras and apps

Biomedical

a) Endoscopy

b) Microscopy

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Beyond Biomedical

Non destructive analysis

of objects of artistic and historic

value

Page 30: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Hyper-Spectral Satellite Imaging

Page 31: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Our contribution: first to develop the all optical

imaging monochromator

Page 32: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Multi-dimensional data set

I@λ3

I@λ2

I@λ1

I@λ4

I@λ5

I@λΝ

•Imaging in a plurality of narrow

spectral bands- spectral cube

•Light intensity recorded in each

band is represented as coordinates

of a multi-dimensional (spectral)

space

• Spectrum: vector of a mutli-

dimensional color space

Page 33: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Development of Spectral Cameras

and Hyper-Spectral Microscopes

Specifications

Spatial resolution: 2 million spectra, one spectrum per pixel

Spectral range: 370-1000nm

Spectral resolution: 34 spectral bands (20nm FWHM)

Color and FCI modes

Scanning time: <1 mim

Real-time, HD-spectral imaging

Operation modes: Reflection, Transmission, Fluorescence

Page 34: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Spectral Classification Algorithms (SCA) I@λ3

I@λ2

I@λ1

I@λ4

I@λ5

I@λΝ

Y

X α

α=angle formed between ref, and test spectrum

X=test spectrum, Y=reference spectrum

YX = averages of X, Y

YM = sample mean vector of class Y

CY= sample covariance matrix of class Y

22

YYXX

YYXXR

22

1

)()(cos

Ya

values: (-1)-(+1)

• Spectral Angle Mapper (SAM)

values: 0o-90o

• Spectral Correlation Mapper (SCoM)

Page 35: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Hyperspectral Endoscopy

Page 36: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Seeing the Invisible….

Visible

Blood vessels Connective tissue

Page 37: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Advanced Hyperspectral Microscopes

Page 38: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Advanced Hyperspectral Microscopes ….offering quantification and mapping in real-time…

Quantitative mapping of estrogen/progesterone receptor expression in breast cells

Quantitative histology Leukemia detection/mapping

Page 39: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

5D Microscopy for Detecting Circulating Tumor Cells (CTCs)

Imaging

detector

Multi-wavelength excitation

light source

Semi-transparent

mirror

Light sourcecontrol

Imaging monochromator control

Data transfer line

Imaging detectorcontrol

spectral cube image stack

Emission cube and spectrum

Excitation emission matrix (one per pixel) Pixel intensity response at different excitation –emission pairs

Excitation cube and spectrum

Micro-5DOutput

Detecting and assessing the metastatic potential of CTCs (OncoSeed Program) ….for personalizing treatments

Page 40: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Hyperspectral Cameras for non destructive analysis of objects of artistic and historic value

I. Palimpsest (72 verso) – Mt. Athos

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Page 41: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Christ on the Cross, New Mexico

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Page 42: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

El Greco St Francis of Assisi

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Page 43: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

SCM

Realgar Minio Cinnabar Hematite Red lake dark Red lake light

-Red: Mix. Of Red lake dark and light

Realgar Minio Cinnabar Hematite Red lake dark light

Pigment identification in Paintings by El Greco

Page 44: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Achievements in Hyperspectral Imaging • The first to develop the all optical imaging

monochromator

• best paper awards

• Pubs Included in Nature-research highlights,

• Patents granted in US

• Technology licensing in EU and USA

• 150 installations world wide incl. Harvard, J&J, Getty

Selected pubs

C. Balas et al , “A Novel Spectral Microscope System: Application in Quantitative Pathology”, IEEE-Transactions on Biomedical Engineering, vol. 50,No. 2, pp. 207-217 N. Kantzilakis, E. Stiakaki, A. Ppadakis, H. Dimitriou, E. Stathopoulos, E. Markaki, C. Balas, M. Kalmanti, “Spectral characteristics of acute lymphoblastic leukemia in childhood”, Leukemia Research, 28 pp 1159-1164, 2004 C. Balas, V. Papadakis, N. Papadakis, A. Papadakis, E. Vazgiouraki, G. Themelis, “A Novel Hyper-Spectral Imaging Apparatus for the Non-Destructive Analysis of Objects of Artistic and Historic Value”, J. of Cultural Heritage, Vol: 4, Supplement 1, January, 2003, pp. 330-337 K. Melessanaki, V. Papadakis, C. Balas, D. Anglos: “Laser Induced Breakdown Spectroscopy (LIBS) and Hyper-spectral Imaging Analysis of Pigments on an Illuminated Manuscript”, Spectrochimica Acta, B: Atomic Spectroscopy, pp. 2337-2346, 2001

http://www.economist.com/node/3786393?story_id=3786393

Other special articles in “Science & Vie”, June 2004, The Times, CNN.com etc.

Page 45: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

Installations in the most prestigious organizations

Page 46: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

A NEW PROJECT STARTED : Quantitative assessment of the pupillary photomotor response dynamics to

tunable, narrow band stimuli Opening a window for

examining brain with light

the first binocular hyperspectral digital

pupillograher, capable of recording pupillary

responses to both monochromatic and

polychromatic stimuli

Page 47: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Grants awarded in 2010

• OncoSeed Diagnostics: Biology of Circulating Tumour Cells, Distant Metastasis & Development of Liquid Biopsy Methods. Funding source: «COOPERATION»-SUB-ACTION ΙΙ:« Large Scale Cooperative Projects». Total budget: €2.000.000, TUC Budget €210.000

• In vivo molecular imaging of epithelial pre‐cancers based on dynamic optical scattering modeling. Funding source: Heraclitus II program for supporting graduate research. Budget €45.000

• Imaging system for assessing papillary response to tunable monochromatic light excitation. Funding source: TUC internal program for supporting graduate research. Budget €15.000

2009

• Contract research in collaboration with FP €30.000

2006-2008,

• ENTER (04-ENTER-72), (GSRT) €78.000

Funding

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Page 48: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Collaborations (indicative)

Imperial College London

St Mary's Hospital London

Hammersmith Hospital London

VU University, Amsterdam

University Medical Centre, Utrecht,

Erasmus University, Rotterdam

Harvard-Wellman Centre for Photomedicine, MA, USA

University of Pittsburgh, PE, USA

Institute Pasteur Paris &Athens

FORTH-IMBB

U-Ioannina

U-Patras

Corallia cluster

H-bio cluster initiative

Forth-Photonics Ltd UK, GR

Johnoson&Johnosn, NJ, USA

Neutrogena, CA, USA

IRIDEX, CA, USA

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Page 49: Electronics lab profile - Corallia · Compact modelling expertise EKV3 () compact model developed (advanced CMOS) DC to RF characterization Ultra-low voltage/Low-power & RF design

ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ

ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής

Conclusions

Over the past years significant efforts directed towards attracting funds for purchasing and setting up (from scratch) lab equipment.

Today the lab’s research facilities are unique and can support ambitious research programs and help in attracting funding

The two activities of the Electronics Lab are unique in Greece and competitive worldwide

The Lab members have established long term collaborations with leading academic institutions. Dept’s students are benefited from this

The Lab members have a significant track record in innovation and technology transfer to industry. The Lab’s educational and research activities has the potential to play a leading role in the further development of the relevant industry in Greece and EU.

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