Dr.PGA Cosmetics What is gamma-PGA - 2013

50
Dr.PGA - Super Hydration YENA TRADING COMPANY Dr.PGA - What is γ-PGA γ-Polyglutamic Acid (γ-PGA) & γ-Polygutamate Hydrogel What is γ- PGA?

description

All about the most efficient natural skin moisturizer every developed gamma-PGA (polyglutamic Acid) or short γ-PGA. The unique functional cosmetic line Dr. PGA uses this moisturizer that is 10 time more powerful than Hyaluronic Acid. Lear more in this presentation...

Transcript of Dr.PGA Cosmetics What is gamma-PGA - 2013

Page 1: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-Polyglutamic Acid (γ-PGA)

& γ-Polygutamate Hydrogel

What is γ-PGA?

Page 2: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

5

Dr. PGA products are the most powerful skin care moisturizing products every developed…

What is γ-PGA?

Page 3: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

5

These trendy Dr.PGA Products contain a new moisturizing agent called: γ-PGA (gamma-PGA).

The patented γ-PGA hydrogel used in these products, is the most powerful hydrating agent ever discovered!

Most powerful moisturizing agent

What is γ-PGA?

Page 4: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

• γ-PGA is the worlds first Auto-Hydrating Agent…..

• γ-PGA is not only Hydrating, but also Lightening……

• γ-PGA is more Hydrating than Hyaluronic Acid / more elastic than Collagen….

• γ-PGA is the best Hydrating Agent, for skin and hair care, ever discovered ….

• γ-PGA can also be used as an anti-aging Skin Filler…..

The most powerful moisturizing agent

6

What is γ-PGA?

Page 5: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA is a wonderful and natural agent, ideal to enhance the effects of health care & skin care products. γ-PGA is integrated into the basic skin care product formulation. It dissolves excellently in water. Your can feel the difference on the soothing, refreshing & moisturizing effect immediately!

FAST MOISTERIZING & REFRESHMENT!

7

γ-PGA IS ALL NATURAL!!

What is γ-PGA?

Page 6: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Originally the substance was discovered in the marine jellyfish. Which helps the jellyfish to store water in its fragile tissue and therefore dose not dehydrate in salty sea water thanks to γ-PGA.

γ-PGA (Gamma-PGA)

Dr.PGA – Power Moisturizing

Page 7: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

A new development for best moisturizing results

γ-PGA and polyglutamates are naturally occurred biopolymers with multifunctional ties. γ-PGA is biosythesized from L-glutamic acid with the microbe “Bacillus subtilis var natto” which has been one of the microbes used to make „Natto“ – fermented soybean, a traditional food and very popular in Japan for over 800 Years.

10

What is γ-PGA?

Page 8: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA is edible, biodegradable, non-toxic to human body and good blood compatible. Its characteristic multi-carboxylic functional groups make it polyanionic bioploymer which has been highly proposed and recommended for use in several fields as….

1. cosmetics moisturizer improving skin care quality, reducing wrinkle conditions and supporting natural moisturizing factor of the skin

2. health care agent for nutrition supplements, facilitating calcium absorption and improving osteoporosis conditions

11

What is γ-PGA?

Page 9: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

3. thickener for the food Industry as well as texture enhancer and as animal feed supplement facilitating mineral absorption

4. absorbent for water treatment for removing heavy metals and radionuclides

5. hydrogel for seed coating and the production of woman tampons due to high water absorbing character

6. hygiene product for baby diapers due to high water absorbent capacity

7. specialty application for biochips, membrane and LCD production due to biocompatibility

8. agriculture agent as natural biocide or inhibitor, it acts anti pathogenic

9. others for the production of biodegradable plastics

12

Page 10: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Natto is the fermented soybean which contains higher vitamin B2 , B6 , B12 , E ,K2 , -PGA and many other digestive enzymes. The sticky material of natto is -PGA.

NATTO & γ-PGA

What is γ-PGA?

Page 11: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA fills up the los of moisture in the skin and has the ability to keep moisture longer in the skin.

What is γ-PGA?

Page 12: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA salt can easily dissolve into water and becomes ionized. (K+ , Na+ , NH4

+ , Ca+2 , Mg+2)• Polyanions• Polyelectrolyte• Macroions

8

What is γ-PGA?

Page 13: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA – hydrogel

γ-PGA powder

Water

After 3 to 4 minutes the water becomes a

gel

γ-PGA has the incredible capacity to bind water. Up to 5000 times it's own molecular weight

What is γ-PGA?

Page 14: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA – hydrogel structure

Microscopic and 3D images of γ-PGA

Microscope image 3D image

What is γ-PGA?

Page 15: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA is a powerful cosmetics moisturizer improving skin care quality, reducing wrinkle conditions and supporting natural moisturizing factor of the skin!

A new development for best moisturizing results

What is γ-PGA?

Page 16: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA Helix Structure

15

What is γ-PGA?

Page 17: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

-PGA is a homopolypeptide made of only glutamic acid in -peptide bond linkage with the degree of polymerization (n) from 1000 to 12´000

16

What is γ-PGA?

Page 18: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Polyglutamic acid solutions have the abilities of skin miniaturization and of melanin inhibition.

The molecular weight of polyglutamic acid can be reduced efficiently by HCl hydrolysis. The viscosity of low molecular weight of polyglutamic acid solutions are not affected by pH values.

When polyglutamic acid is added to emulsion, the particle size of emulsion is reduced and the ability of skin moisturization of the emulsion increases. Polyglutamid acid can be used as an excellent ingredient for skin moisturizers.

17

What is γ-PGA?

Page 19: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Long lasting effects of γ-PGA

The material γ-PGA Hydrogel is with unique surpassing moisture holding capability, combining with functions of different molecules of γ-PGA, can develop longer time of one-way slow release action to thoroughly infiltrate encapsulated active ingredients into deep layer of skin.

What is γ-PGA?

Page 20: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA plays a role as a filler, being able to penetrate into 3 differentlevels of our facial skins due to its different molecule sizes.

γ-PGA can create water channel beneath the skin:

Page 21: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

That's why γ-PGA can quickly fill the gaps between skin cells, diminish the pores and re-firm your facial skin within a moment!.

10

What is γ-PGA?

Page 22: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA is not only an hydrating ingredient for skin but also a good “ carrier “ for other ingredients!

γ-PGA with abundant of negative charges is so good for binding with positively charged trace elements provide the optimal adhesion to the skin which is normally negatively charged.

11

What is γ-PGA?

Page 23: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Dr.PGA Super Hydration for Skin & body

12

γ-PGA Hydrogel

It is a proven fact that the moistur- izing capability of is 10 times more than that of Hyaluronic Acid!

Page 24: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Fermented soybean = NATTO GUM = γ-PGA • International Nomenclature Cosmetic Ingredient (INCI)

NATTO GUM 

• EINECS No. : 310-127-6 The European Inventory of Existing Commercial Substances

(EINECS)

• CAS No. : 9079-02-1 Chemical Abstracts Service Registry No.

Function : film forming

What is γ-PGA?

Page 25: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Polyglutamic Acid Solution

• International Nomenclature Cosmetic Ingredient (INCI)

Polyglutamic acid

• CTFA No.: 5788 The Cosmetic, Toiletry, and Fragrance Association (CTFA)

• CAS No. : 26247-79-0 Chemical Abstracts Service Registry No.

Function : film forming

• CN-Code: 39139080 EU Combined Nomenclature (CN) code

What is γ-PGA?

Page 26: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA vs. Regular Peptidesγ-PGA Regular Peptides

Body Units Glutamic Acid 20 Amino Acids

Photosensitivity Both in L&D-form Mostly in L-form

Amide Linkage γ-peptide α-peptide

R-group Super Hydrophilic Hydrophilic & Hydrophobic

Bonding Molecules 10000 Less than 10000

Bio-degradable Slow Fast

Bio-synthetic germ Few Many

Essential to Body Non-essential Essential

What is γ-PGA?

Page 27: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Schematic representation of the cross-linked structure of a hydrogel including tetrafuncional (A) and multifunctional (B) cross-links, chain ends (C.D.), entanglements (E), loops (F) and unreacted polymer chains (G). The distance between two consecutive cross-links when expressed as molecular weight. Is the molecular weight between cross-links Mc . Upon swelling by a penetrant (•) the space between cross-links (H) is available for diffusion solute flow, etc…

γ-PGA – hydrogel

What is γ-PGA?

Page 28: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA applied onto the skin, can enhance the Natural Moisturizing Factors ( NMF ) from deep inside the skin such as Pyrolidone Carboxylic Acid (PCA), Lactic Acid and Urocanic Acid, so that the skin will recover the natural rehydrating ability.

This effect will never happen for example on Hyaluronic Acid (HA).

γ-PGA truly enhances NMF

Natural Moisturizing Factor

Page 29: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA is known today as the most powerful moisturizer for skin care ever discovered. After using γ-PGA for a minimum of 28 days, it can positively influence and regulate the Natural Moisturizing Factor of the skin.

It also has a special characteristic in supporting active agents of cosmetic products, as a carrier, to penetrate the skin more efficiently.

Natural Moisturizing Factor / NMF of the skin

γ-PGA truly enhances NMF

Page 30: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA 、Hyaluronic Acid (HA)、 Collagen stimulating effect on skin NMF

150

100

50

0

%

0 11 28 days

PGAHACollagen

Note: Applied once daily

Page 31: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Moisturizing effect Test - Comparison between γ-PGA、Hyaluronic Acid (HA) and Collagen in

stratum corneum layer of skin

Collagen HA

γ-PGA

Moisturizing Effect

Page 32: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Trans-Epidermal Water Loss – Test comparison between γ-PGA 、Hyaluronic Acid (HA) and Collagen

80

85

90

95

100

105

110

1 14 28 Days

Collagen

HA

γ-PGA

TEWL Test%

Page 33: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Skin Elasticity Test - comparison between γ-PGA 、Hyaluronic Acid (HA) and Collagen

1 14 28 Days80

85

90

95

100

105

110

115

Collagen HA

γ-PGA

% Skin Elasticity

27

Page 34: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Skin Moisture comparison

Skin Moisture

An age related definciancy state (rough and dark)

γ-PGA replenishes the skin‘s own moisture balance (Brighter, smoother, softer)

Page 35: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA Hyarulonic Acid Collagen

skin miniaturization

water loss of skin

elasticity

extension

NMF growth

ConclusionEnhance skin moisture by functional film

Cover skin with physical film

Cover skin with physical film

Skin Care Comparison between γ-PGA, Hyarolonic Acid and Collagen

Page 36: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA Hyaluronic Acid

Collagen

OriginVegetable

(natto germ)Animal

(chicken crown)Animal

(pig or sheep)

Structure Mono-peptide Bi-saccharide Tri-peptide

Germ Resistance

Elasticity

NMF Growth

Hydrophilicity strong fair weak

pH-balance excellent good good

Skin film smooth sticky sticky

Skin Water Loss

(TEWL)

Conclusion Excellent Good Good

Skin Care Comparison between γ-PGA, Hyaluronic Acid & Collagen

Page 37: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA truly enhances NMF

Test Results. Corneometry

Page 38: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA applied to hair improves surface structure

Before treatment with γ-PGA After 1 week of treatment with γ-PGA

γ-PGA truly enhances NMF

Page 39: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Nucleuscontains vital bioinformation for intra & extra cellular communication

Mitochondria(cross-section)Each cell disposes of several of these „power-stations“

Mitochondria

Energy ReservoirAdenosin-triphosphate (ATP)ATP is a form to keep cellular energy

Mitochondria of each skin cell is involved supporting NMF

O2

ATP

ADPA

From the Blood

CO2

Back to Blood

Energy

DNA

H2O = Natural Moisterizing Factor / NMF

33

Page 40: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

New research reveals - Our top layer of the skin, the stratum corneum, takes its oxygen straight from the air & surrounding. But only moist skin can efficiently absorb oxygen to supply the skin cells. Skin moisturizing is crucial.The skin surface gets its oxygen from the atmosphere, not the blood! Insufficient oxygen supply to the cells reduces the natural moisturizing ability of the skin significantly. Visual signs of dry and ageing skin appear

O2

O2

O2 O2O2 O2

What is γ-PGA?

Page 41: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Markus Stücker of the Ruhr-University in Bochum, Germany, and his dermatologist colleagues have found that air supplies the top 0.25 - 0.4 mm of the skin with oxygen.

This is almost 10 times deeper than previous estimates. This zone includes the entire outermost layer of living cells - the epidermis - and some of the dermis below, which contains sweat glands and hair roots.

R&D Background

35

What is γ-PGA?

Page 42: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

The finding could change skin care specialists approach to skin conditions. Says David Harrison, who studies the use of oxygen by the skin at the University Hospital of North Durham, UK: "Everyone thought that atmospheric oxygen was unimportant, but a significant depth of the skin is supplied from the air and environment."

This fact opens new aspects on using skin care products containing γ-PGA!

R&D Background

36

What is γ-PGA?

Page 43: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

The achievement on the development of γ-PGA received the 2003 national Biotechnology Gold Prize

37

R&D Background

What is γ-PGA?

Page 44: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

2003.12 2003-423533

Biodegradable, High Water Absorbable PGA Hydrogel BY 3-Dimentional Cross-Linking and ITS Preparation Method

2003.12200410004665.6

1-2004-00210

2003.12 092136155

2003.12 03258255.310/740,977

γ-PGA – global patent as brand new hydrating agent

38

What is γ-PGA?

Page 45: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

• Visible signs of dry and aging skin are mainly due to reduced ability of the skin to produce and store moisture. Solution - γ-PGA is the worlds first Auto-Hydrating Agent and can support and regulate in-depth the natural moisturizing factor of skin cells.

• Many are looking today for a natural and non-aggressive way to lighten skin. Solution - γ-PGA is not only a great Hydrating agent but also has excellent Skin Lightening qualities.

Skin Care research offers different interesting aspects for the use and application of γ-PGA :

39

What is γ-PGA?

Page 46: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

• Moist skin is able to absorb much more oxygen then dry skin. Solution - Super hydration of skin with γ-PGA. To ensure a long lasting hydration γ-PGA has the ability to support and store moister in the skin

• Moist skin looks fresher and younger due to hydration and more efficient oxygen supply from the surface.

• Solution: γ-PGA supports the skin to optimize oxygen supply to the skins cells on the surface (the stratum corneum)

40

What is γ-PGA?

Page 47: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

• Hyaluronic Acid and collagen as cosmetic agents are animal based and for many cosmetic users out today.

• Solution – The patented γ-PGA is plant based and more Hydrating than Hyaluronic Acid Hyaluronic Acid reduces, after longer application, the cells natural moisturizing factor of the skin. Additionally γ-PGA A provides more elasticity to the skin than Collagen. γ-PGA can therefore also be used as an effective anti-aging Skin Filler

41

What is γ-PGA?

Page 48: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

γ-PGA is today’s best choice for skin hydration.

γ-PGA is the best & most powerful

Hydrating Agent ever discovered!

42

What is γ-PGA?

Page 49: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Then contact us:

FIBD GmbHWolleraustrasse 41aCH-8807 FreienbachSwitzerland

Email [email protected] www.fibdbusiness.com

Interested in this product line?

Page 50: Dr.PGA Cosmetics   What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY

Dr.PGA - What is γ-PGA

Thank you for your attention!