Diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of...

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Transcript of Diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of...

  • Slide 1
  • Diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of tracerleaflet and inter-leaflet coupling by Reghan J. Hill, and Chih-Ying Wang Proceedings A Volume 470(2167):20130843 July 8, 2014 2014 by The Royal Society
  • Slide 2
  • Scaled mobility 4mh|U/F| versus scaled tracer radius =a/(mh) for cylindrical tracers that span the full width of freely supported (upper) and hydrogel-supported (lower) membranes: circles are numerically exact calculations according to Wang & Hill [12]... Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843 2014 by The Royal Society
  • Slide 3
  • (a) Membrane tracers embedded in solid-supported phospholipid bilayers. Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843 2014 by The Royal Society
  • Slide 4
  • (a) Scaled proximal mobility fp=4mh/ versus scaled inter-leaflet friction coefficient 12 for several values of the scaled proximal-leaflet friction coefficient (proximal configuration) 2=0.001, 0.002, 0.004, 0.01, 0.02, 0.04, 0.1, 0.2, 0.4, 1, 2, 4, 8... Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843 2014 by The Royal Society
  • Slide 5
  • (a) Scaled proximal mobility fp=4mh/ versus scaled particle size 2 for several values of the inter-leaflet friction coefficient (proximal configuration) 12/2=1, 4, 16, 64 (top to bottom): 1/2=104, tm/12=1, tw/2=1. Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843 2014 by The Royal Society
  • Slide 6
  • (a) Scaled proximal mobility fp=4mh/ versus scaled particle size 2 for several values of the inter-leaflet friction coefficient (proximal configuration) 12/2=0.001, 0.1, 10 (top to bottom): 1/2=104, tm=10, tw/2=1. Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843 2014 by The Royal Society
  • Slide 7
  • (a) Scaled proximal mobility fp=4mh/ versus scaled tracerleaflet friction coefficient tm/12 for several values of the scaled particle size 2=0.001, 0.002, 0.004, 0.01, 0.02, 0.04, 0.1, 0.2, 0.4, 1, 2, 4 (top to bottom): 1/2=104 (proximal configura... Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843 2014 by The Royal Society
  • Slide 8
  • Membrane streamlines and velocity profiles (proximal configuration) according to the dual- leaflet model: 1=104, 2=2, 12=1, tm=12, tw=2. Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843 2014 by The Royal Society
  • Slide 9
  • (a) Membrane streamlines and velocity profiles (proximal configuration) according to the dual- leaflet model: 1=104, 2=2, 12=0.01, tm=10, tw=2. Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843 2014 by The Royal Society
  • Slide 10
  • Theoretical predictions of dimensional lipid diffusion coefficients: effects of tracerleaflet (a), leafletleaflet (b) and leafletwall (c) coupling. Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843 2014 by The Royal Society