Diffusion in phospholipid bilayer membranes: dual-leaflet dynamics and the roles of tracer–leaflet and inter-leaflet

coupling

by Reghan J. Hill, and Chih-Ying Wang

Proceedings AVolume 470(2167):20130843

July 8, 2014

©2014 by The Royal Society

Scaled mobility 4πηmh|U/F| versus scaled tracer radius Λ=aη/(ηmh) for cylindrical tracers that span the full width of freely supported (upper) and hydrogel-supported (lower) membranes:

circles are numerically exact calculations according to Wang & Hill [12]...

Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843

©2014 by The Royal Society

(a) Membrane tracers embedded in solid-supported phospholipid bilayers.

Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843

©2014 by The Royal Society

(a) Scaled proximal mobility fp=4πηmh/γ versus scaled inter-leaflet friction coefficient ϵ12 for several values of the scaled proximal-leaflet friction coefficient (proximal configuration)

ϵ2=0.001, 0.002, 0.004, 0.01, 0.02, 0.04, 0.1, 0.2, 0.4, 1, 2, 4, 8 ...

Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843

©2014 by The Royal Society

(a) Scaled proximal mobility fp=4πηmh/γ versus scaled particle size ϵ2 for several values of the inter-leaflet friction coefficient (proximal configuration) ϵ12/ϵ2=1, 4, 16, 64 (top to bottom):

ϵ1/ϵ2=10−4, ϵtm/ϵ12=1, ϵtw/ϵ2=1.

Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843

©2014 by The Royal Society

(a) Scaled proximal mobility fp=4πηmh/γ versus scaled particle size ϵ2 for several values of the inter-leaflet friction coefficient (proximal configuration) ϵ12/ϵ2=0.001, 0.1, 10 (top to bottom):

ϵ1/ϵ2=10−4, ϵtm=10, ϵtw/ϵ2=1.

Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843

©2014 by The Royal Society

(a) Scaled proximal mobility fp=4πηmh/γ versus scaled tracer–leaflet friction coefficient ϵtm/ϵ12 for several values of the scaled particle size ϵ2=0.001, 0.002, 0.004, 0.01, 0.02, 0.04, 0.1, 0.2, 0.4, 1,

2, 4 (top to bottom): ϵ1/ϵ2=10−4 (proximal configura...

Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843

©2014 by The Royal Society

Membrane streamlines and velocity profiles (proximal configuration) according to the dual-leaflet model: ϵ1=10−4, ϵ2=2, ϵ12=1, ϵtm=ϵ12, ϵtw=ϵ2.

Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843

©2014 by The Royal Society

(a) Membrane streamlines and velocity profiles (proximal configuration) according to the dual-leaflet model: ϵ1=10−4, ϵ2=2, ϵ12=0.01, ϵtm=10, ϵtw=ϵ2.

Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843

©2014 by The Royal Society

Theoretical predictions of dimensional lipid diffusion coefficients: effects of tracer–leaflet (a), leaflet–leaflet (b) and leaflet–wall (c) coupling.

Reghan J. Hill, and Chih-Ying Wang Proc. R. Soc. A 2014;470:20130843

©2014 by The Royal Society