Cyclotron Production of I-123 by Bombardment of 124Te ...5isr.triumf.ca/06-CS4(ZhouWei).pdfTe target...

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Cyclotron Production of I-123 by Bombardment of 124 Te Electroplated Target Zhou Wei, Wang Yongxian, Yin Duanzhi Shanghai Institute of Applied Physics, Chinese Academy of Science

Transcript of Cyclotron Production of I-123 by Bombardment of 124Te ...5isr.triumf.ca/06-CS4(ZhouWei).pdfTe target...

Page 1: Cyclotron Production of I-123 by Bombardment of 124Te ...5isr.triumf.ca/06-CS4(ZhouWei).pdfTe target for production of I-123 ¾Metal 124Te target 2πor 4πcooling wet chemical separation

Cyclotron Production of I-123 by Bombardment of 124Te Electroplated Target

Zhou Wei, Wang Yongxian, Yin DuanzhiShanghai Institute of Applied Physics,

Chinese Academy of Science

Page 2: Cyclotron Production of I-123 by Bombardment of 124Te ...5isr.triumf.ca/06-CS4(ZhouWei).pdfTe target for production of I-123 ¾Metal 124Te target 2πor 4πcooling wet chemical separation

Nuclear process for production of 123I

Direct method: (low energy cyclotron) 121Sb(α,2n)123I, natSb(3He,xn)123I,124Te(p,2n)123I, 123Te(p, n)123I,122Te(d,2n)123I ……

Indirect method: 123Xe 123I(medium and high energy cyclotron)127I(p, 5n)123Xe, 124Xe(p, 2n)123Xe124Xe(p, pn)123Xe ……

Page 3: Cyclotron Production of I-123 by Bombardment of 124Te ...5isr.triumf.ca/06-CS4(ZhouWei).pdfTe target for production of I-123 ¾Metal 124Te target 2πor 4πcooling wet chemical separation

Te target for production of I-123

Metal 124Te target2π or 4π cooling wet chemical separation Molten 124TeO2 target4π coolingdry distillation

Page 4: Cyclotron Production of I-123 by Bombardment of 124Te ...5isr.triumf.ca/06-CS4(ZhouWei).pdfTe target for production of I-123 ¾Metal 124Te target 2πor 4πcooling wet chemical separation

Source for 124TeO2 lost

Target heating to liberate 123Iloss of 124TeO2:<1%Accidental melting during irradiation2π cooling systemirradiation angle: 6 ºloss of 124TeO2:3~5%

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Production methodfor electroplated target

124Te electroplated Target----molten target

Irradiation

Wet chemical separation -----dry distillation

Recovery of the enriched tellurium

Quality control

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Targetry Ni surface onto the Cu plate

Ni plating solution:

NiSO4·6H2O

NiCl2·6H2O

H3BO3

pH: 3~4.

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TargetryNi surface onto the Cu plate

Current: 200mATime: 12 min Anode: platinum electrodeCathode: Cu plateCurrent efficiency: 90%Ni thickness: 250ug/cm2

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Targetry Electroplating of enriched 124Te

Stock solution124Te 124Te O 2

KOH solutionpH: 10~11

Page 9: Cyclotron Production of I-123 by Bombardment of 124Te ...5isr.triumf.ca/06-CS4(ZhouWei).pdfTe target for production of I-123 ¾Metal 124Te target 2πor 4πcooling wet chemical separation

Targetry Electroplating of enriched 124Te

Current:100mATime: 60 minThickness: 12mg/cm2

WashDry

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124Te electroplated target

Page 11: Cyclotron Production of I-123 by Bombardment of 124Te ...5isr.triumf.ca/06-CS4(ZhouWei).pdfTe target for production of I-123 ¾Metal 124Te target 2πor 4πcooling wet chemical separation

Irradiation

Cyclone 30 (IBA)Proton energy: 25 MeVBeam current intensity: 20~50µA Time of irradiation: 0.5~3hr 123I yield: 8.2mCi/µA h124Te loss: <1% each run

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Separation of I-123 from tellunium

Dissolution of 124Te(NaOH+ H2O2)Aluminum powerHeating gentlyStream distillationPrecipitation (Te0 +Al(OH)3)FilterRadiochemical yield : >90%

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Recovery of the enriched Te-124

Dissolution of power(Te0 +Al(OH)3)H2SO4 + H2O2

DistillationHypophosphorus acidPrecipitate of telluriumwashed and dried124Te recovery : >99.5%

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Quality ControlRadionuclidic purity

Radioactivity concentration

Radiochemical purity

pH value

Concentration of Al & Te

Bacterial endotoxins

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Result and discussionTargetthickness: Ni 250ug/cm2, Te 12mg/cm2

123I yield: 8.2mCi/µA hr124Te loss: 1% each runRadiochemical yield : >90%124Te recovery : >99.5%

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Influence of beam current intensity on loss of Te

10 20 30 40 50 60 70 80 90 100 1100.0

0.5

1.0

1.5

2.0

2.5

3.0

3.5

4.0

Loss

of T

e (%

)

Beam current intensity (uA)Fig.1 Relationship between loss of Te and beam current intensity

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Influence of thickness of Ni layeron loss of Te

100 150 200 250 300 350 4000.0

0.5

1.0

1.5

2.0

2.5

3.0

3.5

4.0

loss

of T

e (%

)

thickness of Ni layer (ug/cm2)Fig.2 Relationship between loss of Te and thickness of Ni layer

124Te(p,2n)123I 50uA, 1hr

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Influence of thickness of Te on loss of Te

9 10 11 12 13 14 15 160.0

0.5

1.0

1.5

2.0

2.5

124Te(p,2n)123I 50uA, 1hr

loss

of T

e (%

)

thickness of Te(mg/cm2)Fig.3 Relationship between loss of Te and thickness of Te

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Influence of thickness of Te on yield of 123I

10 11 12 13 14 155

6

7

8

9

10

11

124Te(p,2n)123I50uA, 1hr

yiel

d(12

3 I mC

i/uA

hr)

thickness of 124Te(mg/cm2)

Fig.4 Influence of thickness of 124Te on yield of 123I

Page 20: Cyclotron Production of I-123 by Bombardment of 124Te ...5isr.triumf.ca/06-CS4(ZhouWei).pdfTe target for production of I-123 ¾Metal 124Te target 2πor 4πcooling wet chemical separation

Influence of integrated current on yield of 123I

0 50 100 150 2003

4

5

6

7

8

9

10

Yiel

d (m

Ci12

3 I/uA

hr)

Integrated current(uAhr)Fig.5 Relationship between yield of 123I and integrated current

124Te(p,2n)123I124Te target: 13mg/cm2

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Specification of 123I solution

Radionuclidic purity: >98%.

Radiochemical purity: Iodide 123I >95%

Radioactivity concentration: >3700 MBq/mL.pH value: 7.5~9.0Concentration of Al: < 1ug/mLConcentration of Te: <1ug/mLBacterial endotoxins: <30EU/mL

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Thank you for your attention!