CLINICAL CHEMISTRY & SPECIFIC PROTEIN URINE: … · n MAGNESURIA Increasing values are useful for...
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CLINICAL CHEMISTRY & SPECIFIC PROTEIN URINE: ALL YOU CAN TELL US Urine testing provides unique and unrepeatable information pertaining to a multiple series of renal and extra-renal diseases Bence Jones Proteinuria Measurement of free and bound K and λ light chains in liquid chemistry may be useful in the overall evaluation of tubular damages. (Micro) Albuminuria (Micro) Albuminuria represents a strong marker of glomerular damages. The most valuable indication, in addition to renal diseases information, refers to diabetes, arterial hypertension and gravidic gestosis. α-1-Microglobulin and β-2-Microglobulin α-1-Microglobulin and β-2-Microglobulin efficiently detect any damages at tubular level. Increase of these parameters can additionally help identifying Bence Jones Proteinuria. Transferrin Useful in pathologies such as renal failure, especially in case of glomerular deficiencies: by assaying urinary albumin and transferrin, it is possible to have an exact information on the electric charge’s selectivity since both proteins have similar sizes but different charge. MAIN ASPECTS OF URINE TESTING OUR IN VITRO DIAGNOSTICS IDENTITY Liquid chemical and physical analysis n TOTAL PROTEINURIA Total Proteinuria ensures an effective screening with a high predictive value in terms of negatives n PHOSPHATURIA AND CALCIURIA Crucial in phospho-calcium metabolism disorders n AMYLASURIA Very useful for the diagnosis of macroamylasemia n MAGNESURIA Increasing values are useful for the diagnosis of hypoparathyroidism, hyperaldosteronism and out-of-range diabetes. Decreasing values are useful for the diagnosis of hyperparathyroidism and renal failures n UREA Useful for monitoring proteins intake in case of acute malnutrition n CREATININE This parameter is used as a screening test to evaluate kidney function, according to symptoms such as general fatigue, difficulty with urination, swelling in the lower extremities n URIC ACID Increasing values correlate with the risk of nephrolithiasis n GLUCOSE Useful for the differential diagnosis of benign renal glycosuria versus diabetic glycosuria
Transcript of CLINICAL CHEMISTRY & SPECIFIC PROTEIN URINE: … · n MAGNESURIA Increasing values are useful for...
CLINICAL CHEMISTRY & SPECIFIC PROTEIN
URINE: ALL YOU CAN TELL USUrine testing provides unique and unrepeatable information pertaining to a multiple series of renal and extra-renal diseases
Bence Jones ProteinuriaMeasurement of free and bound K and λ light chains in liquid chemistry may be useful in the overall evaluation of tubular damages.
(Micro) Albuminuria(Micro) Albuminuria represents a strong marker of glomerular damages. The most valuable indication, in addition to renal diseases information, refers to diabetes, arterial hypertension and gravidic gestosis.
α-1-Microglobulin and β-2-Microglobulinα-1-Microglobulin and β-2-Microglobulin efficiently detect any damages at tubular level. Increase of these parameters can additionally help identifying Bence Jones Proteinuria.
TransferrinUseful in pathologies such as renal failure, especially in case of glomerular deficiencies: by assaying urinary albumin and transferrin, it is possible to have an exact information on the electric charge’s selectivity since both proteins have similar sizes but different charge.
MAIN ASPECTS OF URINE TESTING
OUR IN VITRO DIAGNOSTICS IDENTITY
Liquid chemical and physical analysis
n TOTAL PROTEINURIA Total Proteinuria ensures an effective screening with a high predictive value in terms of negatives
n PHOSPHATURIA AND CALCIURIA Crucial in phospho-calcium metabolism disorders
n AMYLASURIA Very useful for the diagnosis of macroamylasemia
n MAGNESURIA Increasing values are useful for the diagnosis of hypoparathyroidism, hyperaldosteronism and out-of-range diabetes. Decreasing values are useful for the diagnosis of hyperparathyroidism and renal failures
n UREA Useful for monitoring proteins intake in case of acute malnutrition
n CREATININE This parameter is used as a screening test to evaluate kidney function, according to symptoms such as general fatigue, difficulty with urination, swelling in the lower extremities
n URIC ACID Increasing values correlate with the risk of nephrolithiasis
n GLUCOSE Useful for the differential diagnosis of benign renal glycosuria versus diabetic glycosuria
CLINICAL CHEMISTRY & SPECIFIC PROTEIN
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CLINICAL CHEMISTRY
RANGE OF PRODUCTS
SCLAVO Diagnostics International S.r.l.Via Po 26-28 Località Pian dei Mori I-53018 Sovicille (SI)Ph +39 02 93 991 569 Fax +39 02 93 991 393
[email protected] www.sclavodiagnostics.com
OUR IN VITRO DIAGNOSTICS
IDENTITY
Amylase
Calcium
Creatinine
Glucose
Magnesium
Phosphorus
Urea
Uric Acid
Urine Total Protein
Substrate/Enzymes Calibrator
Normal Control
Abnormal Control
SPECIFIC PROTEINSTurbidimetry/Nephelometry
Alpha1 Microglobulin Latex (A1M)
Beta-2 Microglobulin Latex (B2M)
Urine Kappa Light Chains Free & Bound Latex (uKLC)
Urine Lambda Light Chains Free & Bound Latex (uLLC)
Microalbuminuria (mALB)
Urine Immunoglobulin G Latex (u-IgG)
Urine Transferrin Latex (uTF)
Urine Proteins Multilevel Calibrator
Urine Proteins Control - Low High
