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Transcript of Ceorins
- 1. Pharmacology of Cephalosporins: General OverviewFlavio Guzmn, M.D. http://pharmamotion.com.ar
2. - lactams: cell wall inhibitors 3. -lactam ring
- The -lactam ring is a common structure for:
- Bacteria will target this ring to gain resistance.
4. Cell wall inhibitors: important features
- Cell wall inhibitors have bacericidal effect.
- They act sinergistically with amynoglycosides
- Time-dependent kinetics: the more time the drug binds the bacteria, the more effective it is.
5. Mechanism of action 1
- Some PBP have transpeptidase activity.
- Transpeptidase activity is essential in cell wall synthesis .
- Beta-lactams bindPBP (Penicillin Binding Proteins).
6. Mechanism of action 2 7. Cephalosporins 8. Cephalosporins: characteristics 9. Chemical structure of cephalosporins
- Derived from 7-aminocephalosporanic acid.
- They suffer the attack of bacteria at their beta-lactam ring.
10. First gen. cephalosporins.: 11. 1st Generation cephalosporins: antibacterial coverage Active mainly against Gram positive cocci.Less active against Gram negative. 12. Clinical uses of first gen. cephalosporins 13. 2nd generation cephalosporins 14. 2nd generation cephalosporins. Antibiotic coverage
- Increased coverage against Gram negatives, while keeping coverage against Gram +.
15. 3rd generation cephalosporins 16. 3rd generation cephalosporins Coverage Increased coverage against Gram negatives. Decreased coverage against Gram + 17. 3rd generation cephalosporins Clinical uses 18. Ceftriaxone and meningitis 19. 4th generation cephalosporins 20. 4th generation cephalosporins Antibacterial coverage Coverage against Gram + and Gram -,good activity against -lactamase producing bacteria. 21.