BIODEGRADABLE PHOTOLUMINESCENT POLYLACTONES for MEDICAL APPLICATIONS

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BIODEGRADABLE PHOTOLUMINESCENT POLYLACTONES for MEDICAL APPLICATIONS

Transcript of BIODEGRADABLE PHOTOLUMINESCENT POLYLACTONES for MEDICAL APPLICATIONS

  • 1. BIODEGRADABLE PHOTOLUMINESCENT POLYLACTONES for MEDICAL APPLICATIONS Amrutha K.S. & Susan Zachariah , MSc. Biopolymer Science Centre for Biopolymer Science and Technology(CBPST), Kochi SYNTHESIS applications Freeze dried N2 Vaccum Copolymer Copolymer Filtration Polymer solution PPL Copolymer PPLFiltration Polymer solution 100C 72 h Poly(lactic acid) or polylactide (PLA) is a biodegradable thermoplastic aliphatic polyester derived from renewable resources, such as corn starch , tapioca roots, sugarcane. PLA is one of the few types of biodegradable polymers that have been widely used in FDA approved medical devices such as orthopedic fixation devices, tissue engineering scaffolds and drug-delivering (micro- or nano- )particles. Photoluminescence is light emission from any form of matter after the absorption of photons (electromagnetic radiation). PLA is made intrinsically photo- luminescent without adding traditional photobleaching organic dyes or cytotoxic quantum dots. Biocompatible/ Bioabsorbable. Biodegradable/ Compostable. Derived from renewable resources. Excellent processability and nontoxic. Very good optical properties in terms of transparency and gloss. Biodegradable fluorescent polymers that exhibit dual-functionality as drug delivery carriers and imaging probes. BPLP-PLLAs degradation can be measured by fluorescent signal decay in addition to the traditional weight loss measurements. Cancer fluorescence imaging and drug delivery can be done without the need of conjugation with any organic dyes or quantum dots. BPLP-PLLA copolymers emitted strong fluorescence. BPLP-Cys-PLLA copolymers provided exceptionally high quantum yields. BPLPs has excellent photostability over traditional organic dyes. Better photo-bleaching resistance against continuous illumination over photo- bleaching organic dyes. BPLPLs demonstrate excellent processability. BPLPLs can be feasibly apply into theranostic cancer management. The fluorescence properties of BPLPLs will empower for both in vitro and in vivo detections. By modifying the PLA polymer to be intrinsically fluorescent, it is useful in bioimaging, diagnosis, sensing and other related applications including cancer tissue detection and bone regeneration. Cancer management BPLPLs nanoparticles can target cancer cells and tumors and can also use it to image the tumors via fluorescence imaging. During surgery roughly millimeter-sized tumors can be seen down with the naked eye, other cancerous cells surrounding the tumors cannot be seen. If those cells arent removed, then the cancer will return. Since fluorescence imaging is a very sensitive tool, it can be used to detect those cells that cannot be seen with the naked eye. It is also used to create 'dual-imaging' nanoparticles for cancer treatment ( magnetic resonance imaging and fluorescence imaging). Regenerative engineering By using BPLPLs the decay of temporary scaffolds for tissue regeneration can be identified without re-opening the body. Can measure tissue regeneration in addition to measuring material degradation and therefore we can better design our materials to meet specific medical needs. Recent developments in the field of polymer science and technology has led to the development of BPLPLs for the targeted delivery of proteins to colon, and chemotherapeutic agents to tumors. Novel BPLPLs may prepare for oral insulin delivery. Luminescent polymers for in vivo imaging of amyloid signatures, diagnostic imaging of Alzheimer's disease (AD) and prion diseases. DNA /Gene detection. New synthetic methods have been used to prepare homo and co polymeric BPLPLs for a wide range of drugs, peptides, and protein delivery applications. BPLPLs could also be incorporated in catheters for diagnostic and therapeutic purposes. 1H NMR spectrum Microscopic fluorescence image PLA http://news.psu.edu/-chemistry--conventional-polymers/biomedical http://www.bioe.psu.edu http://www.plastemart.com http://cordis.europa.eu