Arginine metabolism by aslam matania

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Transcript of Arginine metabolism by aslam matania

  1. 1. ARGININE METABOLISM BY ASLAM MATANIA GROUP-3 FACULTY OF MEDICINE TSMU
  2. 2. WHAT IS ARGININE? Arginine is an -amino acid In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.
  3. 3. STRUCTURE The amino acid side-chain of arginine consists of a 3-carbon aliphatic straight chain, the distal end of which is capped by a complex guanidinium group
  4. 4. METABOLISM The two main sites of endogenous arginine synthesis are LIVER(where arginine is both synthesis and hydrolyzed within urea cycle)and KIDNEY CORTEX where most of the synthesized L-arginine is released into blood and transported throughout body
  5. 5. Cytosolic Enzyme required are- argininosuccinate synthetase(ASS) andargininosuccinate lyase(ASL) It require 2 ATP
  6. 6. synthesis of arginine occurs in intestinalrenal axis which producecitrulline fromglutamineandglutama te, kidney, which extract
  7. 7. ARGININE PATHWAY
  8. 8. CITRULLINE AND ARGININE CYCLE
  9. 9. The enzyme nitric oxide synthase (three isoenzymes) cleaves the nitrogen from the guanidino group of arginine to form NO. Requires NADPH, FMN, FAD, heme & tetrahydrobiopterin(BH4)
  10. 10. AGMATINE Agmatine: It is a derivative of arginine produced in the brain by decarboxylation. Agmatine possesses antihypertensive properties.
  11. 11. Abnormalities Except arginase other enzyme def. in urea cycle distrubs arginine level in the body. Hyperargininemia inborn error in arginine metabolism due to a defect in the enzyme arginase. Hypoargininemia premature occurs before the burst of cortisol production that occurs late in preg. Cortisol is req for activation of arginine synthetic enzymes Remedy + of cortisol to infant(premature) may improve growth and survival rate