Antibodies for Amyloid Precursor Protein (APP) Processing

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Secretase α Secretase sAPPβ AICD M3.2 Secretase γ APP N-Terminus C-Terminus APP γ Secretase Cleavage Aβ 2H4 2-8 Aβ 6E10 3-8 Aβ 4G8 18-23 APP D3B10 61-77 β β Sec Secr r sAPP β APP 1G6 573-596 61-77 APP LN27 A β 18 sAPPα Aβ 38 x-38 Legend α Secretase APP N-Terminus sAPPβ APP 1G6 573-596 APP D3B10 61-77 61-77 APP LN27 Aβ 1E11 2-8 γ Secretase Transmembrane APP γ Secretase α Secretase AICD C-Terminus α Secretase Aβ 20.1 1-10 ret retase se Aβ NAB228 1-11 Aβ 20.1 1-10 Aβ NAB228 1-11 β Secretase Aβ 6E10 3-8 1 16 17 Aβ 4G8 18-23 β Secretase A β 6E1 3-8 Rodent Aβ Aβ 20.1 1-10 et Aβ NAB228 1-11 Aβ 2H4 2-8 Aβ 1E11 2-8 Rodent Aβ M3.2 sAPPα C Term Frag C-Term Frag Antibodies for Amyloid Precursor Protein (APP) Processing C-Term Frag C1/6.1 β Secretase Cleavage Aβ 1E11 2-8 Rodent Aβ Aβ 40 x-40 Aβ 42 x-42 Aβ 43 x-43 Aβ 38 x-38 Aβ 40 x-40 Aβ 42 x-42 Aβ 43 x-43 C Term Frag C1/1.6 Aβ 4G8 18-23 α Secretase Cleavage Covance provides additional formats such as conjugation with secondary labels includeing HRP, Biotin, AlexaFluor® dyes, etc. Alexa Fluor® is a registered trademark of Moleclular Probes, Inc. Transmembrane Aβ 6E10 3-8 Rodent Aβ Rodent Aβ M3.2 Rodent Aβ Aβ 2H4 2-8 sAPPα

Transcript of Antibodies for Amyloid Precursor Protein (APP) Processing

Page 1: Antibodies for Amyloid Precursor Protein (APP) Processing

Secretase α Secretase

sAPPβAICD

M3.2

Secretaseγ

APP

N-T

erm

inus

C-T

erm

inus

APP

γ Secretase Cleavage

Aβ 2H42-8

Aβ 6E103-8

Aβ 4G818-23

APP D3B1061-77

ββ SecSecrr

sAPPβ

APP 1G6573-596

61-77

APP LN27

Aβ18

sAPPα

Aβ 38x-38

Legend

α Secretase

APP

N-T

erm

inus

sAPPβ

APP 1G6573-596

APP D3B1061-7761-77

APP LN27 Aβ 1E112-8

γ Secretase

Transmembrane

APP

γ Secretase

α Secretase

AICDC

-Ter

min

us

α Secretase

Aβ 20.11-10

retretasese

Aβ NAB2281-11

Aβ 20.11-10

Aβ NAB2281-11

β Secretase

Aβ 6E103-8

1 16 17

Aβ 4G818-23

β Secretase

Aβ 6E13-8Rodent Aβ

Aβ 20.11-10

et

Aβ NAB2281-11

Aβ 2H42-8

Aβ 1E112-8

Rodent AβM3.2 sAPPα

C Term Frag

C-Term Frag

Antibodies for Amyloid Precursor Protein (APP) Processing

C-Term FragC1/6.1

β Secretase Cleavage

Aβ 1E112-8

Rodent AβAβ 40x-40

Aβ 42x-42

Aβ 43x-43

Aβ 38x-38

Aβ 40x-40

Aβ 42x-42

Aβ 43x-43

C Term FragC1/1.6

Aβ 4G818-23

α Secretase Cleavage

Covance provides additional formats such as conjugation with secondary labels includeing HRP, Biotin, AlexaFluor® dyes, etc.

Alexa Fluor® is a registered trademark of Moleclular Probes, Inc.

Transmembrane

Aβ 6E103-8

Rodent Aβ

Rodent AβM3.2

Rodent Aβ

Aβ 2H42-8

sAPPα

Page 2: Antibodies for Amyloid Precursor Protein (APP) Processing

Gamma Secretase Complex ComponentsAntibody Clone Catalog #

Nicastrin, C-Term POLY PRB-365P

Nicastrin, N-Term POLY PRB-364P

Nicastrin POLY SIG-39370

Presenilin 1, N-Term 24-4B5 SIG-39190

Presenilin 1 NT1 SIG-39194

Presenilin 1, Loop 34-4C3 SIG-39198

Presenilin 1, C-Term POLY PRB-355P

Presenilin 1, N-Term POLY PRB-354P

Presenilin 2 PS2 MMS-359S

Notch POLY SIG-39172Aph-1aL/C-Term (245-265)

POLY PRB-550P

Aph-1aL/S Loop (92-115)

POLY PRB-551P

Aph-1b/C-Term (245-257)

POLY PRB-552P

Aph-1b/Loop POLY PRB-553P

Pen-2, C-Term POLY PRB-599C

Pen-2, N-Term POLY PRB-560C

Protein Cross-Reactivity

Antibody Clone Catalog # EpitopeSpecies

Reactivity

Full Length APP

Beta Amyloid

38

Beta Amyloid

40

Beta Amyloid

42

Beta Amyloid

43 sAPPa sAPPb AICDC-Term

Fragment

Beta Amyloid N-TerminusBeta Amyloid 1-8, Purified 1E11 SIG-39110 2-8 H X X X X X X

Beta Amyloid 1-8, Purified 2H4 SIG-39120 2-8 H X X X X X X

Beta Amyloid, Purified 20.1 SIG-39350 1-10 H X X X X X X

Beta Amyloid, Ascites NAB 228 MMS-532R 1-11 H X X X X X X

Beta Amyloid 1-16, Purified 6E10 SIG-39320 3-8 H X X X X X X

Beta Amyloid 1-16, Low Endotoxin 6E10 SIG-39321 3-8 H X X X X X X

Beta Amyloid 1-16, Purified POLY SIG-39322 3-8 H X X X X X X

NEW Rodent Beta Amyloid M3.2 SIG-39155 1-16 H, R X X X X X X

Rodent Beta Amyloid, Purified POLY SIG-39153 R X X X X X X

Beta Amyloid 17-24, Purified 4G8 SIG-39220 18-23 H, R X X X X X

Beta Amyloid C-TerminusRabbit Monoclonal 38, Purified BA1-13 SIG-39160 x-38 H, R X

Beta Amyloid 40, Purified 11A50-B10 SIG-39140 x-40 H, R X

Rabbit Monoclonal 40, Purified 29-6 SIG-39164 x-40 H, R

Beta Amyloid 40, Purified POLY SIG-39130 x-40 H, R X

Rabbit Monoclonal 42, Purified BA3-9 SIG-39168 x-42 H, R X

Beta Amyloid 42, Purified 12F4 SIG-39142 x-42 H, R X

Beta Amyloid 42, Purified POLY SIG-39134 x-42 H, R X

Beta Amyloid 43, Purified 9C4 SIG-39143 x-43 H, R X

Amyloid Precursor ProteinAPP, Purified LN27 SIG-39188 H X X X

APP, Purified 1G6 SIG-39180 573-596 H X X X

APP, Purified D3B10 SIG-39184 61-77 H X X X

sAPPa, Purified POLY SIG-39139 H X

sAPPb, Purified POLY SIG-39138 H, R X

Gamma Secretase Cleavage FragmentsAICD, Purified POLY SIG-39148 H X

C-Term Fragment, Purified POLY SIG-39150 H X X

NEW C-Term Fragment, Purified C1/6.1 SIG-39152 H, R X X X

BetaMark™ ELISA KitsBeta Amyloid x-40, Chemiluminescent SIG-38950 H, R X

Beta Amyloid x-40, Colorimetric SIG-38954 H, R X

Beta Amyloid 1-40, Chemiluminescent SIG-38951 H X

Beta Amyloid x-42, Chemiluminescent SIG-38952 H, R X

Beta Amyloid x-42, Colorimetric SIG-38956 H, R X

Beta Amyloid 1-42, Chemiluminescent SIG-38953 H X

NEW Total Beta Amyloid 1-x, Chemiluminescent SIG-38966 H, R X X X X

sAPPb, Chemiluminescent SIG-38960 H, R X

Species Reactivity Key: H=Human, R=Rodent. Covance can custom conjugate any of our antibodies to meet your research needs. Contact us to learn more.

APP Processing/Beta Amyloid Antibodies

APP/Beta Amyloid ProteinsDescription Catalog #

sAPPb Recombinant Protein SIG-39938

Beta Amyloid 40 Peptide rPEP-597P

Beta Amyloid 42 Peptide rPEP-590PBeta Amyloid 42 Peptide, Scrambled

rPEP-598P

Additional Key TargetsAntibody Clone Catalog #a-Synuclein LB509 SIG-39726

a-Synuclein, TC LB509 SIG-39725

a-Synuclein 4D5 SIG-39720

a-Synuclein 4B12 SIG-39730

a-Synuclein Syn204 MMS-530R

a-Synuclein, Nitrated Syn514 MMS-556R

a/b-Synuclein Syn202 MMS-529Ra/b-Synuclein, Nitrated

Syn12 MMS-555R

Apo-E4 5G7 SIG-39752

Apo-E4 9D11 SIG-39754

NEW

NEW

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