Analyze User Instructions, adapted from MVT Bob Schwanke Siemens WITH FUNDING SUPPORT PROVIDED BY...
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Transcript of Analyze User Instructions, adapted from MVT Bob Schwanke Siemens WITH FUNDING SUPPORT PROVIDED BY...
Analyze User Instructions, adapted from MVT
Bob SchwankeSiemens
WITH FUNDING SUPPORT
PROVIDED BY NATIONAL
INSTITUTE OF STANDARDS AND
TECHNOLOGY
QI-Bench Overview
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Formulate
Statistical Analysis Results (Relation
strength)
Annotation and Image Markup,
Non-imaging Clinical Data
Primary Data: Images and other
Raw Data
Reference Data SetsQIBO
Specify
RDF Triple Store
CT Volumetry CT
obtained_by
Tumor growth
measure_of
TherapeuticEfficacy
used_for
Analyze
Y=β0..n+β1(QIB)+β2T+ eij
Execute
Feedbac k
Feed
bac
k
BiomarkerDB.SummaryStatistic+ = Analyze ({ReferenceDataSet .CollectedValue});
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Role Use Case Supported Now Gap vs. Model
Domain expert
Run and modify statistical analyses
Web App (thin) n/a Create the web app
Informaticist
Configure set of analysis scripts in toolbox
Desktop (thick)
Run relevant calculations at technical performance level
Persist statistical calculations results as N-ary relations in knowledge store, across larger data sets and at clinical level too
IT systems expert
Configure data input and output services
Server-sideConnects to (some)caGrid data services
Connect directly to RDSM and knowledge store (and through Formulate, broader set of data services)
Load Cases and Run MVT (measurement variability tool)
AIM output for selected case (from Batch Analysis Service)
Choose Analysis Type (we’ll be adding new Types)
Ground truth can be direct or indirect
Deselect RECIST and WHO measurements
Choose Biomarker Measurements to Analyze (we’ll be adding Measurements)
R Script for summary statistic
Some Methods exist; we will create new ones (e.g., factor analysis)
Column per measurement
Columns for calculation according to the Methods
Intra- and Inter-reader comparisons
Output of Analysis Type run (this example intra-reader)
Inter-reader measurements
Output of Analysis Type run (this example inter-reader)
… calculated
Additional outputs based on Methods
Outliers list
Outlier Analysis with Drill-down is Supported (access to raw imagery)
Configure plots as needed
Resulting plots – we’ll be adding plot types, e.g., box, radar, and K-M
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