AMPK Signaling: The Fuel Sensor and Regulator...
Transcript of AMPK Signaling: The Fuel Sensor and Regulator...
AMPK-α(1,2)
AMPK-β(1,2) AMPK-γ(1,2,3)
TAK1
Leptin
AMP/ATP LKB1 ATM Akt
IL-6Insulin
PP2CCaMKKCa2+
Adiponectin
Lipolysis
Fatty AcidSynthesis
CholesterolSynthesis
Fatty AcidOxidation
Fatty AcidUptake
HSL
HMG-CoAReductase
PEPCKG6Pase
AS160TBC1D1
MEF2AMEF2D
Malonyl-CoA
SREBP-1C
ACC1
ACC2
CPT-1
MCD
LPLCD36
GlycogenSynthesis
GLUT4Biogenesis
GLUT4Translocation
GlucoseUptakeGlycolysis
Gluconeogenesis
GSK-3
GS
PFK2NO
Synthesis
EnergyExpenditure
eNOS
NAD+/NADH
TSC1/TSC2
4EBP1eIF4E
SIRT1
ProteinTranslationInitiation
PeptideElongation
MitochondrialBiogenesis
ProteinTranslation
eEF2K
eEF2
mTORRheB
p70S6KPGC-1α
S6
NRF-1
AICARExercise
Discover more at abcam.com/AMPKsignaling
AMPK Signaling: The Fuel Sensor and Regulator Pathway
Produced in collaboration with Ding An, Ph.D., Postdoctoral Fellow and Laurie J Goodyear, Ph.D., Associate Professor of Medicine, Harvard Medical School & Senior Investigator and Head, Section on Metabolism, Joslin Diabetes Center.
Legend:
Regulation of AMPK
Lipid Metabolism
Carbohydrate Metabolism
Protein Synthesis
Others
Activation
Activation (not fully confirmed)
Inhibition
Discover more at abcam.com/AMPKsignaling
081-09/09-PW
Copyright © 2013 Abcam. All Rights Reserved.
AMPK Signaling: The fuel sensor and regulator Pathway
Antibody Clonality Applications Host Species Reactivity Product Code
Adiponectin M IHC-P, WB, ELISA, ICC/IF Ms Hu, Ms, Bb ab22554
Akt1 protein (tagged) WB Hu ab43619
Akt2 protein Inhib Hu ab42593
Akt3 protein (active) SDS-PAGE, FuncS Hu ab79799
AMPK alpha 1 M IHC-P, IP, WB Rb Hu, Ms, Rat ab32047
AMPK alpha 1 + AMPK alpha 2 (phospho S485 + S491) P ELISA, IHC-Fr, IHC-P, WB Rb Hu, Ms, Rat ab39400AMPK alpha 1 + AMPK beta 1 + AMPK gamma 1 protein (active) FuncS, SDS-PAGE Hu ab79803
AMPK alpha 1 peptide BL Hu ab40461
AMPK alpha 2 P IP, WB Rb Hu, Ms, Rat, Cow ab3760
AMPK alpha 2 peptide BL Hu ab40462
AMPK beta 1 M Flow Cyt, IHC-P, IP, WB Rb Hu, Ms, Rat ab32112
AMPK gamma 1 M Flow Cyt, ICC, IHC-P, IP, WB Rb Hu ab32382
ATM M ICC/IF, IHC-P, IP, WB Rb Hu ab32420
CaMKK M IHC-P, WB Ms Hu ab57913
CaMKK protein (tagged) SDS-PAGE, FuncS Hu ab55692
CD36 M BL, Flow Cyt, IHC-Fr, IP, WB Ms Hu, Rat ab17044
CPT1A P WB, ELISA Gt Hu, Predicted: Chmp, RMk ab53532
EEF2K protein (active) SDS-PAGE, FuncS, WB Hu ab84570
eIF4E P ICC/IF, IP, WB Rb Hu ab1126
eNOS P IHC-P Ms Hu, Predicted: Ms, Rat, Cow, Dog, Pig ab15280
GLUT4 P IHC-P, WB Rb Hu, Predicted: Ms, Rat, Cow, Goat, Hrs, Rb, Shp ab33780
HMG-CoA reductase / HMGCR (phospho S872) P WB Rb Hu, Ms, Predicted: Rat ab78275
HSL / LIPE P WB, ELISA Chk Hu, Ms, Rat ab17652
Insulin protein (active) SDS-PAGE, FuncS Hu ab73797
Leptin protein WB, ELISA Hu ab13987
LKB1 M IHC-P, WB, ELISA, ICC/IF Ms Hu ab15095
MEF2A P ELISA, ICC/IF, IHC-P, WB Rb Hu, Ms, Rat ab51153
mTOR P ICC, IHC-Fr, IP, WB Rb Hu, Ms, Rat ab2732
NRF1 M IHC-P, WB Ms Hu ab55744
PEPCK1 / PCK1 P IHC-P, WB Rb Hu, Rat ab28455
PFK2 / PFKFB2 P WB, ELISA Rb Hu ab70175
PGC1 alpha P IHC-P, WB, ELISA Rb Hu, Ms, Predicted: Rat, Chk, Cow, CynMk, Dog, Hrs, Op, Pig, RMk
ab54481
S6K protein (active) SDS-PAGE, FuncS Hu ab62291
SIRT1 M IHC-P, ICC, WB, IP Rb Hu ab32441
TAK1 P ELISA, ICC/IF, IHC-P, WB Rb Hu, Predicted: Ms, Rat ab79354
TBC1D1 P WB Rb Hu, Ms ab84692
Related antibodiesAMPK alpha 1 + AMPK alpha 2 (phospho S485 + S491) (ab39400)Clonality Applications P ELISA, IHC-Fr, IHC-P, WBHost Species cross reactivity Rb Hu, Ms, Rat
ATM (ab32420)Clonality Applications M ICC/IF, IHC-P, IP, WBHost Species cross reactivity Rb Hu
MEF2A (ab51153)Clonality Applications P ELISA, ICC/IF, IHC-P, WBHost Species cross reactivity Rb Hu, Ms, Rat
mTOR (ab2732)Clonality Applications P ICC, IHC-Fr, IP, WBHost Species cross reactivity Rb Hu, Ms, Rat
SIRT1 (ab32441)Clonality Applications M IHC-P, ICC, WB, IP Host Species cross reactivity Rb Hu
Product
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