ALTERNATIVE THERAPIESI N H E A L T H A N D M E D I C I N E

A PEER-REVIEWED JOURNAL • JULY/AUGUST 2015 • VOL. 21, NO. 4 • $14.95

Terpenes in Chemical Sensitivity • Acupressure for Persistent Cancer-related Fatigue • NF-κΒ and TNF-α Activation by Electroacupuncture

to Suppress Rheumatoid Arthritis • Horticultural Therapy: Modulating Cortisol and Indices of Substance Craving,

Posttraumatic Stress Disorder, Depression, and Quality of Life • Immune Activation Through Diet-associated Stimuli • Efficacy of the Wen Dan Decoction for Metabolic Syndrome • Treatment of a Medial Collateral Ligament Sprain Using Prolotherapy • Commentary—Why

Does Treatment Fidelity Matter? • Conversations—Michael Smith, MD: Part 2 • Editorial—Vaccines: Both Sides of the Same Coin

Order Today! Call: 800 692 9400

Open an Account metagenics.com/newaccount

Learn More SpectraZyme.com

There are hidden sources of gluten everywhere, making it as uncomfortable

to avoid as it may be to digest. SpectraZyme Gluten Digest is an innovative

digestive enzyme formula that has been clinically shown to help break down

gluten proteins before they reach the small intestine.*

• Shown to help break down gluten proteins in humans, in vitro, and in a gastrointestinal model*

• Demonstrated to provide more efficient breakdown of gluten than leading competitor products*

• Clinically demonstrated to break down gluten before it reaches the small intestine, which is key to supporting health outcomes*

• Provides digestive support for those avoiding gluten consumption*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Notice: This product is not intended to replace a gluten-free diet and not intended to treat or prevent celiac disease.

Introducing

SpectraZyme® Gluten DigestTargeted Support for Enzymatic Breakdown of Gluten*

Gluten has finally met its match

©2015 Metagenics, Inc. All Rights Reserved

Science-based Products

Lifestyle Medicine Programs

Unsurpassed Quality

Practitioner Partnership

Breakthrough Research

The Metagenics Difference+ + + + =

SpectraZyme Ad Alt Therapies/IMCJ 8.375 x 11.125.indd 1 5/22/15 2:28 AM

Tel: 805.693.1802 • Fax: 805.693.1806 • CustomerService@ResearchedNutritionals.comwww.ResearchedNutritionals.com | Available only through healthcare professionals

CALL 800.755.3402

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Complete Mitochondrial SupportATP Fuel®

ATP Fuel® starts with the base of our highly acclaimed NT Factor Energy™ phospholipid delivery system for mitochondrial membrane support. Stabilized NADH and CoEnzyme Q10 are incorporated to promote healthy Krebs output.

Lipid Replacement Therapy with a Glyco-

phospholipid Formulation with NADH and

CoQ10 Significantly Reduces Fatigue in

Intractable Chronic Fatiguing Illnesses and

Chronic Lyme Disease Patients

Garth L. Nicolson, Ph.D., Robert Settineri, M.S. and Rita Ellithorpe, M.D.

The International Journal of Clinical Medicine

ATP FUEL ®

Peer-Reviewed

Research Published May 2012

Glycophospholipid Formulation with NADH and CoQ10 Significantly Reduces Intractable

Fatigue in Western Blot-Positive ‘Chronic Lyme Disease’ Patients: Preliminary ReportGarth L. Nicolson, Ph.D., Robert Settineri, M.S. and Rita Ellithorpe, M.D.

The Journal of Functional Foods in Health and Disease

ATP FUEL ®

Peer-Reviewed

Research

Published March 28, 2012

Clinical Research

Presented at ILADS Annual ConferenceToronto, Ontario, Canada

ATP Fuel®

Joseph Burrascano Jr., MD“Due to the efficacy & purity of these products, these are some of my favorites”

PEER-REVIEWED PUBLISHED RESEARCH

Experience the only liposomal glutathione that you squeeze onto a teaspoon and enjoy. No need to mix in juice. Natural orange flavor & GMO-free.

HIGH DOSEEach serving offers:

• 450 mg of reduced glutathione• 50 mg of Vitamin C

HEAT STABLEWe contracted with a third party lab to subject Tri-Fortify™ Orange to the most extreme conditions: 104˚F and 75% humidity for 90 consecutive days. The result: product met and exceeded the nutrient content on the label.

Oral Liposomal Glutathione GelTri-Fortify™ Orange

G

MO FREE

DAIRY FREE

HE

AT STABL

E

VE G A N

VE

G ETA RIAN

DAIRY FREEG

MO FREE

VE G A N

HE

AT STABL

E

VE

G ETA RIAN

RE

FRIG ERATION

NO

G

MO FREE

DAIRY FREE

HE

AT STABL

E

VE G A N

VE

G ETA RIAN

DAIRY FREEG

MO FREE

VE G A N

HE

AT STABL

E

VE

G ETA RIAN

RE

FRIG ERATION

NO

G

MO FREE

DAIRY FREE

HE

AT STABL

E

VE G A N

VE

G ETA RIAN

DAIRY FREEG

MO FREE

VE G A N

HE

AT STABL

E

VE

G ETA RIAN

RE

FRIG ERATION

NO

Tel: 805.693.1802 • Fax: 805.693.1806 • CustomerService@ResearchedNutritionals.comwww.ResearchedNutritionals.com | Available only through healthcare professionals

CALL 800.755.3402

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Joseph Burrascano Jr., MD“Due to the research basis of these formulations, I think these products would be an important part of a practitioner’s arsenal.”

Healthy Cytokine SupportCytoQuel™ has been developed to promote healthy cytokine activity. Based on the latest published research, CytoQuel™ offers doctors a valuable new tool in the quest for healthy inflammation levels.

Each capsule includes therapeutic levels of:

( N-acetyl cysteine (NAC) ( Black Tea Extract ( CurcuWIN™ tumeric extract ( Pure Tocotrienols (optimized absorption) ( Resveratrol (Natural Trans-Resveratrol)

Microbinate™ is formulated to promote a healthy response to today’s vast microbial challenges. Each capsule combines nature’s most potent and well-researched nutrients into one complete product with therapeutic levels of:

( Oregano Extract (30% carvacrol) ( Monolaurin ( Olive Leaf Extract ( Stabilized Allicin (the active ingredient in garlic) ( CurcuWIN™ tumeric extract

Microbial Health Complex

Microbial & CytokineSupport

x ALTERNATIVE THERAPIES, JUL/AUG 2015 VOL. 21, 4 3Table of Contents

TABLE OF CONTENTSJULY/AUGUST 2015, VOL. 21, NO. 4

8 Vaccines: Both Sides of the Same Coin Andrew W. Campbell, MD

12 Terpenes and Terpenoids in Chemical Sensitivity William J. Rea, MD, FACS, FAAEM; Carolina Restrepo, MD; Yaqin Pan, MD

18 Self-administered Acupressure for Persistent Cancer-related Fatigue: Fidelity Considerations Gwen Wyatt, RN, PhD, FAAN; Dawn Frambes, RN, BSN, MSA; Richard E. Harris, PhD; John Todd Arnedt, PhD; Susan L. Murphy, ScD, OTR; Suzanna M. Zick, ND, MPH

26 Targeting NF-κΒ and TNF-α Activation by Electroacupuncture to Suppress Collagen-induced Rheumatoid Arthritis in Model Rats Jia Li, PhD; Jing Li, PhD; Rui Chen, PhD; Guowei Cai, PhD

36 Horticultural Therapy: A Pilot Study on Modulating Cortisol Levels and Indices of Substance Craving, Posttraumatic Stress Disorder, Depression, and Quality of Life in Veterans Mark B. Detweiler, MD, MS; Jennifer A. Self, PhD; Sandra Lane, MA; Luise Spencer; Brian Lutgens, MSW; Dong-Yun Kim, PhD; Mary H. Halling, MSN; Tammie F. Rudder, RN, MSN; Lauren Lehmann, MD

42 Food Intolerance: Immune Activation Through Diet-associated Stimuli in Chronic Disease Nicole Pietschmann, PhD

54 Efficacy of the Wen Dan Decoction, a Chinese Herbal Formula, for Metabolic Syndrome Yan-Mei Huang, MD; Jia-Hua Xu, MB; Wei Ling; MD; Yang Li, MD; Xiao-Xi Zhang, PhD; Zhi-Kai Dai, MPhil; Yi Sui, PhD; Hai-Lu Zhao, PhD

68 Treatment of a Medial Collateral Ligament Sprain Using Prolotherapy: A Case Study Ahmet Mustafa, ADA, MD; Ferdi Yavuz, MD

w w w . a l t e r n a t i v e - t h e r a p i e s . c o m

EDITORIAL

ALTERNATIVE THERAPIESI N H E A L T H A N D M E D I C I N E

PILOT STUDY

Original Research

REVIEW ARTICLE

META-ANALYSIS

CASE STUDY

4 ALTERNATIVE THERAPIES, JUL/AUG 2015 VOL. 21, 4 Table of Contents

72 Michael Smith, MD: Treat the Underlying Causes of Weight Gain to Facilitate Successful Weight Loss—Part 2: Examining the First 2 Pillars of Weight Gain Interview by Craig Gustafson

24 Why Does Treatment Fidelity Matter? Jennifer A. M. Stone, LAc

76 Conference Calendar

79 Resources

CONVERSATIONS

ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE (ISSN 1078-6791) is published 6 times per year (January, March, May, July, September, November) by InnoVision Professional Media, 3140 Neil Armstrong Blvd, Suite 307, Eagan, MN, 55121, Tel: (877) 904-7951, Fax: (651) 344-0774. E-mail: ATHM@innovisionhm.com. Copyright 2015 by InnoVision Professional Media. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage retrieval system without permission from InnoVision Professional Media. InnoVision Professional Media assumes no liability for any material published herein. Before photocopying items, please contact the Copyright Clearance Center, Customer Service, 222 Rosewood Dr, Danvers, MA 01923. Telephone: (978) 750-8400. All statements are the responsibility of the authors. Alternative Therapies in Health and Medicine is indexed in Index Medicus, CINAHL, Science Citation Index-Expanded (SciSearch®), ISI (Institute for Scientific Information) Alerting Services, Current Contents®/Clinical Medicine, EMBASE (Excerpta Medica), and MEDLINE.

The statements and opinions contained in the articles in Alternative Therapies in Health and Medicine are solely those of the individual contributors and not of the editors or InnoVision Professional Media. Advertisements in this journal are not a warranty, endorsement, or approval of the products by the editors of this journal or InnoVision Professional Media, who disclaim all responsibility for any injury to persons or property resulting from any ideas or products referred to in the articles or advertisements.

For subscription questions please call toll-free: US only, (877) 904-7951; outside the US, (651) 251-9684. Annual individual subscriptions: US and possessions: $95; foreign: $155 (US). Institutional rates: US: $255; foreign: $375 (US). Single copies: US: $15; all other countries: $25 (US). Periodical postage paid at St Paul MN, and additional mailing offices (USPS #015874). Postmaster: Send address changes to ALTERNATIVE THERAPIES, PO Box 11292, St Paul, MN 55111. Allow 4 to 6 weeks for change to take effect. The name and title ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE is protected through a trademark registration in the US Patent Office. Printed in the USA.

Innovision PROFESSIONAL media, INc.3140 Neil Armstrong Blvd, Suite 307 • Eagan, MN • Tel: (877) 904-7951• Fax: (651) 344-0774 • Web: www.alternative-therapies.com

President & Group Publisher, DICK BENSON • Vice President & CFO, JOHN BENSON • IT Manager, SAM BHATT

Advertising Sales

DAVID BENSON • (651) 251-9623 • david@innovisionhm.com

All rights reserved. Reproduction in whole or in part without specific written permission from Alternative Therapies in Health and Medicine is prohibited by law.

Cover image used under license from Shutterstock.com, 2015.

PERSPECTIVES

departments