Allergy Year in Review 2012

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Proceedings of the Allergy Year in Review organised by the Allergy Dpt

Transcript of Allergy Year in Review 2012

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  • 13

    1. Ivana V. Yang, PhD, and David A. Schwartz, MD Epigenetic mechanisms and the

    development of asthma. J Allergy Clin Immunol 2012;130:1243-55 2. Stephanie Brand, PhD,a Dorthe Andrea Kesper, PhD,a Ren_e Teich, PhD,b Esma Kilic-

    Niebergall, MSc,a Olaf Pinkenburg, PhD,a Evita Bothur, MSc,c Michael Lohoff, MD,c Holger Garn, PhD,a Petra Ina Pfefferle, PhD, DrPH,a and Harald Renz, MDa. DNA methylation of TH1/TH2 cytokine genes affects sensitization and progress of experimental asthma. J Allergy Clin Immunol 2012;129:1602-10

    3. Jones B, Chen J. Inhibition of IFN-gamma transcription by site-specific methylation 4. during T helper cell development. EMBO J 2006;25:2443-52 5. White GP, Hollams EM, Yerkovich ST, Bosco A, Holt BJ, Bassami MR, et al. 6. CpG methylation patterns in the IFNgamma promoter in naive T cells: variations 7. during Th1 and Th2 differentiation and between atopics and non-atopics. Pediatr Allergy

    Immunol 2006;17:557-64. 8. Lee DU, Agarwal S, Rao A. Th2 lineage commitment and efficient IL-4 production 9. involves extended demethylation of the IL-4 gene. Immunity 2002;16:

    10. 649-60. 11. Maes T, Provoost S, Lanckacker EA, Cataldo DD, Vanoirbeek JA, Nemery B, et al. 12. Mouse models to unravel the role of inhaled pollutants on allergic sensitization and airway

    inflammation. Respir Res 2010;11:7. 13. Provoost S, Maes T, Willart MA, Joos GF, Lambrecht BN, Tournoy KG. Diesel exhaust 14. particles stimulate adaptive immunity by acting on pulmonary dendritic cells. J Immunol

    2010;184:426-32. 15. Provoost S, Maes T, Joos GF, Tournoy KG. Monocyte-derived dendritic cell recruitment 16. and allergic T(H)2 responses after exposure to diesel particles are CCR2 dependent. J

    Allergy Clin Immunol 2012;129:483-91. 17. von Bubnoff D, Geiger E, Bieber T. Antigen- presenting cells in allergy. J Allergy Clin

    Immunol 2001;108:329339. 18. Sokol CL, Chu NQ, Yu S, Nish SA, Laufer TM, Medzhitov R. Basophils function as 19. antigen-presenting cells for an allergen induced T helper type 2 response. Nat Immunol 20. 2009;10:713720. 21. Yoshimoto T, Yasuda K, Tanaka H, Nakahira M, Imai Y, Fujimori Y et al. Basophils

    contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide- 22. MHC class II complexes to CD4+ T cells. Nat Immunol 2009;10:706712. 23. Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR et al. 24. MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine

    dependent 25. immunity. Nat Immunol 2009;10:697705 26. Hammad H, Plantinga M, Deswarte K, Pouliot P, Willart MA, Kool M et al. Inflammatory 27. dendritic cellsnot basophilsare necessary and sufficient for induction of Th2 immunity to

    inhaled house dust mite allergen. J Exp Med 2010;207:20972111. 28. Eckl-Dorna J, Ellinger A, Blatt K, Ghanim V, Steiner I, Pavelka M et al. Basophils are 29. not the key antigen-presenting cells in allergic patients. Allergy 2012;67:601608 30. Hoffmann P, Boeld TJ, Eder R, Huehn J, Floess S, Wieczorek G, et al. Loss of FOXP3

    expression in natural human CD41CD251 regulatory T cells upon repetitive in vitro stimulation. Eur J Immunol 2009;39:1088-97.

    31. Kearley J, Barker JE, Robinson DS, Lloyd CM. Resolution of airway inflammation 32. and hyperreactivity after in vivo transfer of CD41CD251 regulatory T cells is

  • 14

    33. interleukin 10 dependent. J Exp Med 2005;202:1539-47. 34. Kearley J, Robinson DS, Lloyd CM. CD41CD251 regulatory T cells reverse established 35. allergic airway inflammation and prevent airway remodeling. J Allergy Clin Immunol

    2008;122:617-24. 36. Becker C, Kubach J,Wijdenes J, Knop J, Jonuleit H. CD4-mediated functional activation of

    human CD41CD251 regulatory T cells. Eur J Immunol 2007;37:1217-23. 37. Ji J, Cloyd MW. HIV-1 binding to CD4 on CD41CD251 regulatory T cells enhances their

    suppressive function and induces them to home to, and accumulate in, peripheral and mucosal lymphoid tissues: