A Computational Approach for Defining a Signature of β ...

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1 A Computational Approach for Defining a Signature of β-Cell Golgi Stress in Diabetes Mellitus Robert N. Bone 1,6,7 , Olufunmilola Oyebamiji 2 , Sayali Talware 2 , Sharmila Selvaraj 2 , Preethi Krishnan 3,6 , Farooq Syed 1,6,7 , Huanmei Wu 2 , Carmella Evans-Molina 1,3,4,5,6,7,8* Departments of 1 Pediatrics, 3 Medicine, 4 Anatomy, Cell Biology & Physiology, 5 Biochemistry & Molecular Biology, the 6 Center for Diabetes & Metabolic Diseases, and the 7 Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202; 2 Department of BioHealth Informatics, Indiana University-Purdue University Indianapolis, Indianapolis, IN, 46202; 8 Roudebush VA Medical Center, Indianapolis, IN 46202. *Corresponding Author(s): Carmella Evans-Molina, MD, PhD ([email protected]) Indiana University School of Medicine, 635 Barnhill Drive, MS 2031A, Indianapolis, IN 46202, Telephone: (317) 274-4145, Fax (317) 274-4107 Running Title: Golgi Stress Response in Diabetes Word Count: 4358 Number of Figures: 6 Keywords: Golgi apparatus stress, Islets, β cell, Type 1 diabetes, Type 2 diabetes Page 1 of 781 Diabetes Diabetes Publish Ahead of Print, published online August 20, 2020

Transcript of A Computational Approach for Defining a Signature of β ...

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A Computational Approach for Defining a Signature of β-Cell Golgi Stress in Diabetes Mellitus

Robert N. Bone1,6,7, Olufunmilola Oyebamiji2, Sayali Talware2, Sharmila Selvaraj2, Preethi Krishnan3,6, Farooq Syed1,6,7, Huanmei Wu2, Carmella Evans-Molina 1,3,4,5,6,7,8*

Departments of 1Pediatrics, 3Medicine, 4Anatomy, Cell Biology & Physiology, 5Biochemistry & Molecular Biology, the 6Center for Diabetes & Metabolic Diseases, and the 7Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202;

2Department of BioHealth Informatics, Indiana University-Purdue University Indianapolis, Indianapolis, IN, 46202; 8Roudebush VA Medical Center, Indianapolis, IN 46202.

*Corresponding Author(s):

Carmella Evans-Molina, MD, PhD ([email protected])

Indiana University School of Medicine, 635 Barnhill Drive, MS 2031A, Indianapolis, IN 46202,

Telephone: (317) 274-4145, Fax (317) 274-4107

Running Title: Golgi Stress Response in Diabetes

Word Count: 4358

Number of Figures: 6

Keywords: Golgi apparatus stress, Islets, β cell, Type 1 diabetes, Type 2 diabetes

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Diabetes Publish Ahead of Print, published online August 20, 2020

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ABSTRACT

The Golgi apparatus (GA) is an important site of insulin processing and granule maturation, but

whether GA organelle dysfunction and GA stress are present in the diabetic β-cell has not been

tested. We utilized an informatics-based approach to develop a transcriptional signature of β-cell

GA stress using existing RNA sequencing and microarray datasets generated using human islets

from donors with diabetes and islets where type 1(T1D) and type 2 diabetes (T2D) had been

modeled ex vivo. To narrow our results to GA-specific genes, we applied a filter set of 1,030

genes accepted as GA associated. In parallel, we generated an RNA-sequencing dataset from

human islets treated with brefeldin A (BFA), a known GA stress inducer. Overlapping the T1D

and T2D groups with the BFA dataset, we identified 120 and 204 differentially expressed genes,

respectively. In both the T1D and T2D models, pathway analyses revealed that the top pathways

were associated with GA integrity, organization, and trafficking. Quantitative RT-PCR was used

to validate a common signature of GA stress that included ATF3, ARF4, CREB3, and COG6.

Taken together, these data indicate that GA-associated genes are dysregulated in diabetes and

identify putative markers of β-cell GA stress.

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INTRODUCTION

Diabetes mellitus impacts over 425 million individuals worldwide, and this number is

expected to approach 629 million by the year 2045 (1). Type 1 diabetes (T1D) accounts for 5-

10% of all diabetes cases and results from autoimmune destruction of pancreatic β cells, whereas

type 2 diabetes (T2D) accounts for 90-95% of cases and results from a combination of peripheral

insulin resistance and β-cell dysfunction (2). While the origins of T1D and T2D have been

viewed classically as distinct, inadequate insulin secretion plays a central role in the

pathophysiology of both forms of diabetes. Accumulating data suggest that common β-cell

stress pathways underlie the diminished insulin secretory capacity and reduced β-cell survival

observed during T1D and T2D progression.

The primary function of the β cell is to rapidly sense elevations in blood glucose and

respond with carefully titrated levels of insulin secretion (3). To meet the heavy biosynthetic

burden of insulin production, β cells possess a highly developed secretory pathway in which

insulin is sequentially folded, processed, and packaged into vesicles for exocytosis. Insulin

production begins within the lumen of the endoplasmic reticulum (ER) with conversion of

preproinsulin to proinsulin following cleavage of the preproinsulin signal peptide by signal

peptidase (3). Proinsulin exits the ER and enters the Golgi apparatus (GA), where it undergoes

packaging into early secretory vesicles, and these immature vesicles undergo a series of

maturation steps (3). Cleavage of proinsulin by prohormone convertases to produce mature

insulin begins within the trans-GA sub-compartment, and this process is completed within the

mature secretory vesicles (3). The mild acidity of the GA aids the maturation of the prohormone

convertases needed for insulin maturation (3), and this process continues and accelerates in the

more acidic secretory vesicles to form mature insulin granules. The vesicles are then stored near

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the plasma membrane as a readily releasable pool that is rapidly mobilized during glucose-

stimulated insulin secretion (3). As insulin accounts for nearly half of the total protein produced

in β cells (4), disruptions in the fidelity of proinsulin processing and alterations in secretory

organelle function can significantly affect β-cell function and health (5; 6).

In this regard, ER stress has been well documented as playing a role in the pathogenesis

of both T1D and T2D (7-10), and the tripartite ER stress response has been studied extensively,

resulting in multiple well-validated protein and transcriptional markers of ER stress. The

concept of GA stress has been proposed primarily in the context of neurologic disorders (11; 12)

but has also been suggested to occur in other secretory cells, such as monocytes (13) and

Brunner’s gland cells (14). Several candidate GA stress markers were recently identified in

other cell types and linked with GA morphologic changes observed by electron microscopy (15).

In contrast with ER stress, the pathways underlying GA stress are incompletely described and

may be much more diverse in nature (14). Despite the importance of the GA in insulin

processing and maturation, whether GA stress plays a role in β cells or if it exists in either T1D

or T2D remain unclear.

To this end, we identified publicly available human islet datasets from T1D and T2D

models, including a combination of datasets from donors with diabetes and datasets where

diabetes pathophysiology was modeled ex vivo, and we analyzed these datasets for changes in

the expression of GA-associated genes. In parallel, we treated human islets with the known GA

stress inducer brefeldin A (BFA) and used a computational approach to identify overlap between

the T1D, T2D, and BFA datasets. From this analysis, we identified a set of genes and pathways

associated with β-cell GA stress in diabetes.

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RESEARCH DESIGN AND METHODS

Selection and Classification of Datasets

Studies of interest were identified by searching specific terms in the NCBI Gene

Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/gds). Search terms

included: “islet & cytokine,” “islet & palmitate,” “islet & type 2 diabetes,” and “islet & type 1

diabetes.” Some datasets were found in more than one search query, but these were weighted

equally with datasets appearing in only one query. Datasets were excluded if the primary tissue

was not human islets or if there was no non-diabetic control or control condition available for

comparison. The experimental procedures of all the publicly available microarray and RNA-

sequencing human pancreatic islets samples used in this paper have been fully described

elsewhere (16-24).

T1D datasets included cadaveric human islets treated with or without pro-inflammatory

cytokines analogous to autoimmune mediated β-cell insult in T1D (datasets 1 (18) and 3 [data

under review; islets treated with or without 50 U/mL IL-1β and 1000 U/mL IFNγ for 24 h] and

from organ donors with T1D [dataset 2]) (25). T2D datasets included cadaveric human islets

from donors diagnosed with T2D (datasets 4 & 5) (17; 24) and cadaveric human islets treated

with palmitate as a model of T2D (dataset 6) (16). The BFA dataset (dataset 7) included

cadaveric human islets treated with BFA or DMSO as a control. Further information on the

dataset characteristics, including GEO accession numbers, number of samples, profiling

technology, and number of probe sets or genes, is shown in Table 1. Human islet donor

characteristics are shown in Table 2.

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Generation of BFA-treated Human Islet Datasets

For the generation of the BFA dataset, human cadaveric donor islets were obtained from

the Integrated Islet Distribution Program (26). Upon receipt, islets were allowed to recover

overnight in phenol red–free DMEM containing 10% FBS, 10 mM HEPES, 2 mM L-glutamate,

and 100 U/0.1 mg/L penicillin/streptomycin. Islets were handpicked (250 per condition) and

then treated for 24 h with DMSO or 0.1 µg/mL BFA. Islets were collected, washed in PBS, and

lysed in TRIzol (Thermo Fisher Scientific, Waltham, MA). Total RNA was isolated using a

miRNeasy kit (Qiagen, Hilden, Germany) for RNA-sequencing and RNeasy Micro kit for qRT-

PCR. Raw data were deposited in the GEO database (GSE152615).

RNA-Seq Library Preparation and Sequencing of BFA-treated Islets

The concentration and quality of total RNA samples were first assessed using an Agilent

2100 Bioanalyzer. A RIN (RNA Integrity Number) ≥5 was required to pass quality control (RIN

8.063 ± 0.4031). Then, 100 ng of RNA per sample were used to prepare single-indexed strand-

specific cDNA libraries using a KAPA mRNA Hyperprep kit (Roche Sequencing & Life

Science, Indianapolis, IN). The resulting libraries were assessed for quantity and size

distribution using Qubit and an Agilent 2100 Bioanalyzer. Pooled libraries (300 pM) were

sequenced with a 2×100 bp paired-end configuration on a NovaSeq6000 (Illumina, San Diego,

CA). A Phred quality score (Q score) was used to measure the quality of sequencing. More than

90% of the sequencing reads reached Q30 (99.9% base call accuracy).

Data Preprocessing and Normalization

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For microarray datasets, transcriptomic data were background adjusted, summarized, and

normalized to probe sets using Robust Multi-Array Average methods from the Bioconductor

package Affy in R (27) for datasets 4 and 5. Batch correction of dataset 5 was performed using

the ComBat function from the R/Bioconductor package sva (28). Probe sets were then annotated

with their associated gene symbols using Annotation GPL files GPL96 (dataset 4) and GPL570

(dataset 5). Some of the probe sets for each dataset had the same gene symbols, and for each of

these redundancies, the probe set with the greatest average expression across all samples was

chosen to represent each unique gene.

RNA-sequencing datasets, including the three GEO datasets (GSE35296, GSE102371,

and GSE53949) and the two in-house datasets, were normalized using the reads per kilobase per

million mapped reads (RPKM) method. The transcript expressions of all RNA-seq data were

mapped to the hg19 human reference genome using STAR RNA-seq aligner (30). To account

for negative values during log transformation in the gene RPKM expression, a pseudocount of 1

was added.

Statistical Analysis of Differentially Expressed Genes

Statistical analysis was performed to detect differentially expressed genes (DEGs). For

datasets 4 and 5, the empirical Bayes moderated t statistics test was applied using the

R/Bioconductor packages Limma (28), with the p-values corrected for age and sex covariates.

For dataset 7, the analysis was performed using the Bioconductor packages EdgeR and limma.

DEGs were identified at p-values < 0.5 and classified as upregulated or downregulated based on

the log fold-change (FC). For the remaining four datasets, t-tests were performed to identify

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significant DEGs. The p-values were corrected for false discovery rate (FDR) using the

Benjamini-Hochberg method. The log FC was calculated as the log2 transformation by dividing

the RPKM expression of all genes under palmitate treatment by their corresponding RPKM

expression under control conditions.

Corrected p-values (<0.05) were taken as the threshold for significant differences in gene

expression. In addition, a log FC of 1.5 was necessary to be considered a DEG. A gene was

selected as up-regulated or down-regulated if at least 80% of islet samples exhibited a significant

change in its expression in one direction and none in the opposite direction. The numbers of

normalized transcripts are listed in Table 1.

Downstream Analysis of DEGs

For all datasets used, the DEGs were filtered to GA-associated genes using the 1,030

genes identified as localized to the GA as defined by the human protein atlas

(http://www.proteinatlas.org/humancell/golgi+apparatus). All DEGs are listed in Supplemental

File 1. To identify and visualize the functional profiles for genes and gene clusters, further

analyses were performed to identify the significant gene ontology (GO) terms, including

biological processes, cellular components, and molecular functions, from the enriched genes in

the T1D, T2D, and BFA datasets in relation to GA stress in β cells, using the Bioconductor

clusterProfiler R package (29).

Quantitative RT-PCR (qRT-PCR)

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qRT-PCR was performed as previously described (10). For ARF4, ATF3, CREB3, and

ACTB, qRT-PCR was performed using SsoAdvanced Universal SYBR Green Supermix (Bio-

Rad, Hercules, CA). For COG6, GOSR2, and ACTB, qRT-PCR was performed using TaqMan

Fast Advanced Master Mix (ThermoFisher, Waltham, MA). Primers used are listed in

Supplemental Table 1.

Data and Resource Availability

The dataset generated during the current study is available in the Gene Expression

Omnibus (GEO) repository (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE152615).

All data analyzed during this study are included in the published article and its online

supplementary files.

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RESULTS

Differentially Expressed GA-associated Genes in T1D

Following normalization by RPKM, datasets 1-3 were analyzed for DEGs to gain insight

into whether β-cell GA stress exists in human models of T1D. Datasets 1 and 3 were from

human islets treated ex vivo with pro-inflammatory cytokines, which is an established model of

T1D (30). In contrast, dataset 2 included islets from organ donors with T1D. We identified a

total of (upregulated/downregulated) 946 (367/579), 1,168 (162/1,006), and 2,434 (934/1,500)

DEGs from these three T1D datasets, respectively.

Because overlap between the three datasets was minimal, we used DEG summation for

filtering with Golgi genes. Summation resulted in 5,195 unique DEGs (FC >1.5, FDR <0.05),

irrespective of profiling technology. After filtering, 611 unique DEGs were found to be GA

associated (Fig. 1A). A complete list of DEGs can be found in Supplemental File 1. To simplify

functional enrichment and pathway analyses, a more stringent cutoff (FDR <0.01) was applied,

yielding 173 GA-associated DEGs that were used to elucidate GA-associated pathways involved

in T1D.

Functional enrichment yielded 182 pathways, and the top five pathways and their

associated DEGs were visualized in a cnetplot (Fig. 1B). These top five pathways were “Golgi-

associated vesicle,” “Golgi-associated vesicle membrane,” “MHC protein complex,” “cellular

response to interferon-gamma,” and “response to interferon-gamma.” Among these pathways,

common GA-associated genes involved included HLA-DQA1, HLA-DRA, HLA-DPA1, HLA-F,

and HLA-B, which have been identified as components of the class I and II major

histocompatibility complex and are integral to the autoimmune response during T1D (31). Of

note, HLA-F is known to be localized to the GA and not the cell surface like other HLAs (32).

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We also identified several genes involved in ER-to-GA and GA-to-ER transport, including

COPZ2 and KDELR1 (33; 34).

GA-associated DEGs in T2D

We followed a similar workflow to analyze datasets from cadaveric human donors with

T2D (datasets 4 & 5) or human islets from non-diabetic donors that had been treated ex vivo

with palmitate (dataset 6). We identified (upregulated/downregulated) 2,466 (884/1,582), 1,722

(931/791), and 300 (80/220) DEGs from the three T2D datasets, respectively. Similar to the

T1D datasets, DEG summation was performed and further filtered for GA-associated genes.

Summation resulted in 8,969 DEGs (FC >1.5, FDR <0.05) and 1,013 GA-associated DEGs after

applying the Golgi filter (Fig. 2A). A more stringent cutoff (FDR <0.01) was used to simplify

the analysis and resulted in 386 DEGs and 390 pathways. Of the 390 pathways, the top five

were “endomembrane system organization,” “Golgi organization,” “ER to Golgi vesicle-

mediated transport,” “Golgi vesicle transport,” and “trans-Golgi network,” and these pathways

were visualized with their associated DEGs in a cnetplot (Fig. 2B). Three GA-associated genes,

VTI1A, RAB30, and COG7, were common among the top five pathways and have been identified

as important to GA transport and localization (35).

BFA Induces GA-associated DEGs in Human Islets

BFA is a known inducer of GA stress (11); however, no GEO-deposited dataset is

available for BFA-treated human islets. To this end, cadaveric human islets from four non-

diabetic donors were treated with 0.1 μg/mL BFA for 24 h, followed by RNA sequencing as

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outlined in the Materials and Methods (dataset 7). Principle component analysis showed a clear

separation between the DMSO control–treated islets and BFA-treated islets (Fig. 3A).

Differential expression analysis of dataset 7 identified 8,667 DEGs, with 4,289 genes showing a

pattern of upregulation and 4,378 showing a pattern of downregulation (FC >1.5, FDR <0.05).

BFA-treated islet DEGs were visualized in a volcano plot (Fig. 3B), with the top 50 DEGs

labeled. Functional enrichment of the DEGs revealed 1,034 significant pathways (FDR <0.05),

and the top five pathways were visualized as a cnetplot (Fig. 3C). Consistent with the notion

that BFA is a GA stress inducer, these pathways included “endomembrane system organization,”

“ER to Golgi vesicle-mediated transport,” “Golgi organization,” “Golgi vesicle transport,” and

“post-Golgi vesicle-mediated transport.”

DEGs were then filtered for Golgi-related genes, yielding 503 DEGs, of which 251 were

upregulated and 252 downregulated (Fig. 4A). Functional enrichment of 364 DEGs (FDR

<0.01) revealed 110 significant pathways, and the top five pathways were visualized in an

alluvial plot (Fig. 4B). Pathway analysis identified the top five significant pathways as “Intrinsic

component of Golgi membrane,” “Golgi organization,” “Golgi vesicle transport,” “Retrograde

vesicle-mediated transport, Golgi to ER,” and “Golgi stack.” Commonly found genes included

COG3, COG2, GOLPH3, GBF1, and GOLGA2, all associated with GA localization, trafficking,

and integrity (35).

Overlap of DEGs Among the T1D, T2D, and BFA Groups

To identify genes that may serve as markers of GA stress in diabetes, we generated sets

of genes that overlapped between the T1D and BFA datasets and the T2D and BFA datasets,

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with and without GA-filtering. The overlap of T1D and BFA genes included 2,289 DEGs (Fig.

5A), and after filtering for GA-associated genes, 121 were found to be common (Fig. 5C). The

overlap of T2D and BFA genes included 3,540 DEGs (Fig. 5B), and following GA-filtering, 204

DEGs were common (Fig. 5D). Overlap among all three groups yielded 55 GA-associated

DEGs (Fig. 5E). GO functional enrichment analysis was performed using ClusterProfiler R,

which analyzed and visualized the functional profiles of genes and gene clusters (33). GO

enrichment analysis returned 475 GO terms for T1D, 261 for T2D, 108 for BFA, and 29 GO

terms common to all three groups (FC >1.5, FDR<0.05). To visualize the overlapping GO

terms, we generated a heatmap with GA-associated genes and GO terms from our three groups

(Fig. 5F). Common GO terms included “ER to Golgi vesicle-mediated transport,” “endosome

membrane,” “trans-Golgi network,” and “transport vesicle.” Examples of unique GO terms

included “clathrin-coated endocytic vesicle” and “regulation of TNF production” in T1D,

“protein localization to ER” and “angiogenesis” in T2D, and “synaptic vesicle” and “ARF

protein signal transduction” in BFA.

Candidate GA Stress Gene Validation

From our BFA-treated islet GA-associated DEGs, we selected five genes for validation as

induced by GA stress in islets: CREB3, ARF4, ATF3, COG6, and GOSR2. CREB3, ARF4, and

ATF3 were previously reported as GA stress markers (14). COG6 (FC 2.541, FDR 2.16E-05)

and GOSR2 (FC 2.251, FDR 8.89E-06) were among the most highly expressed GA-associated

DEGs in our BFA dataset. COG6 is a subunit of the GA required for maintaining normal GA

structure and activity (36), and GOSR2 is a trafficking protein in the medial- and trans-GA

compartments (37).

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Next, islets from human cadaveric donors (Table 2), which were distinct from donor

islets used for RNA sequencing, were treated with 0.1 μg/mL BFA or DMSO for 24 h. qRT-

PCR revealed significantly higher expression of CREB3, ARF4, ATF3, and GOSR2 in BFA-

treated islets (Fig. 6A-D). COG6 expression was also increased in BFA-treated islets, but not

significantly (p=0.087; Fig. 6E).

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DISCUSSION

In order to maintain blood glucose homeostasis and robust levels of insulin production,

pancreatic β cells are subject to a heavy biosynthetic burden that renders them susceptible to

influences that disrupt secretory pathway organelle function. Stress within the ER arising from

calcium dyshomeostasis, oxidative stress, lipotoxicity, and inflammatory stress are well regarded

as disruptive to insulin transcription, maturation, and secretion (5; 6; 8-10). The impact of GA

stress on β-cell function, however, is largely unknown and further complicated by the lack of

validated GA stress markers. Herein, we sought to address this knowledge gap by utilizing an

informatics-based approach using publicly available datasets from T1D and T2D human islet

models and our own sequencing dataset from human islets treated with the known GA stress

inducer BFA.

Evidence from other cell types suggests that the GA is capable of acting as a cell sensor.

The GA’s response to stressors that modify or compromise secretory function was initially

identified from morphologic assessments, in which the GA was described as having a swollen or

fragmented appearance (11; 12). GA dysfunction can occur in response to pH modification and

extrinsic stressors that interrupt GA-mediated posttranslational modifications or interfere with

vesicle transport. In addition, the secretion of large amounts of proteins has been shown to

impair GA glycosylation and transport (38), and GA morphologic changes have also been

observed after viral infection, such as GA fragmentation and dispersal resulting from herpes

virus infection (39). Much of the evidence for GA stress has been discerned from studies of

neurodegenerative diseases (11; 12; 40), but GA stress has also been observed or implicated in

skeletal muscle disorders (41), alcohol-induced liver disorders (42), and disorders affecting

monocytes (13) and intestinal Brunner’s gland cells (43). Notably, monocytes and Brunner’s

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gland cells are secretory cell types, secreting cytokines (44) and mucins (45), respectively. With

emerging evidence indicating that GA stress also affects other secretory cells, it stands to reason

that GA stress may also affect β cells.

Similar to the process of ER stress, GA stress has been linked with increased

transcription of genes or activation of signaling pathways that are thought to increase the

functional capacity of the GA as a means of restoring organelle homeostasis (11). However, in

contrast to ER stress, markers for these responses are limited. Recently, a few candidate markers

have been identified in other cell types, including TFE3, HSP47, and CREB3 (14; 38). TFE3 is

a transcription factor that promotes transcription of GA structural proteins, glycosylation

enzymes, and a transport protein (38). HSP47 is an ER chaperone induced by GA stress that

prevents GA-induced apoptosis (14; 38). CREB3 is a transcription factor that activates ARF4,

which is a GA-localized regulator of GA-to-ER vesicle transport. ARF4 activity is impaired by

the GA-stress inducer BFA (14; 38).

The goal of this study was to identify putative transcriptional signatures of GA stress in

diabetic β cells. To this end, we examined T1D and T2D datasets from publicly available and in-

house sources. Differential expression analysis indicated that DEG overlap within each group

was minimal; therefore, DEG summation was used for both the T1D and T2D datasets. Each

group was then filtered for GA-associated genes using a list of 1,030 genes reportedly specific to

the GA according to the Human Protein Atlas. The T1D group included 611 GA-associated

DEGs, whereas the T2D group included 1,013 GA-associated DEGs. Following pathway

analysis, both the T1D and T2D datasets revealed multiple pathways associated with GA

integrity, organization, and transport. In addition, T1D datasets revealed pathways associated

with the immune system, including the notable identification of the MHC complex pathway.

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MHC molecules are processed in the GA before transport to the cell surface, directly for MHC-II

and some MHC-I molecules (46; 47). Some MHC-I molecules are subsequently transported

back to the ER before transport to the cell surface (48). Islet MHC-I is associated with increased

ER stress and elevated cell-surface expression in T1D (49). Interestingly, increased MHC-I

production and shuttling through the secretory pathway was shown to also induce GA stress in a

myositis model of skeletal muscle MHC-I overexpression (41). T2D datasets centered on

pathways associated with either GA organization or transport. In this regard, disruption of either

ER-to-GA or GA-to-ER transport has been linked with reduced insulin production and secretion

and T2D pathophysiology (50; 51).

BFA causes GA stress by collapsing the GA, and BFA has been used to prevent cytokine

secretion in immune cells (22). In liver and cancerous cells, prolonged BFA exposure has been

shown to induce the unfolded protein response and eventually apoptosis (14; 52). Within β cells,

BFA reportedly inhibits glucose-stimulated insulin secretion (53-55). To define the overlap

between DEGs from T1D and T2D datasets with a known GA stressor, we generated a dataset

using BFA-treated human islets. To the best of our knowledge, this is the first RNA-sequencing

dataset from BFA-treated human islets. The BFA dataset itself had 8,164 DEGs, with 503

associated with the GA. After overlap of GA-associated DEGs from the BFA dataset and the

T1D and T2D groups, 121 and 204 DEGs were identified, respectively. These results suggest

that GA stress may be more prominent in T2D. To further assess overlap, we examined GO

terms from the T1D, T2D, and BFA datasets. Twenty-nine GO terms were common to all three

groups. Several GO terms were associated with the Golgi complex and involved in mediating

transport within the GA or between the GA and other parts of the cell, whereas several others

were associated with GA structure.

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For validation of our analysis, we selected five highly expressed DEGs from BFA-treated

islets based on candidate markers from the literature (CREB3, ARF4, ATF3) and components

associated with GA integrity and trafficking (COG6 and GOSR2). Our validation set also

identified increased expression of the previously implicated GA-stress candidate markers

CREB3, ARF4, and ATF3. These genes were differentially expressed in the analyzed datasets:

CREB3 in two T2D datasets, ARF4 in one T2D dataset, and ATF3 in one T1D and two T2D

datasets. The conserved oligomeric Golgi (COG) complex is composed of eight subunits and

impacts trafficking, glycosylation, and GA integrity (56). COG6 was upregulated in our BFA-

treated islets, and COG2 and COG4 were differentially expressed in at least one dataset in our

diabetic groups, suggesting the expression of components of the COG complex may be altered

by GA stress or diabetic stress. The COG complex has been implicated in BFA-induced GA

collapse (57) but not as a marker of GA stress and thus represents an avenue for future

investigation. GOSR2 is a member of the GA SNARE transport complex involved in trafficking

and glycosylation (37). GOSR2 was differentially expressed in two T2D datasets and our BFA

dataset, and we observed a trend towards increased GOSR2 expression in our validation set.

Our results found increased expression of the ATF3 gene, which encodes activating

transcription factor 3 (ATF3). ATF3 is a member of the CREB family of transcription factors

and is induced by multiple β cell stressors, including proinflammatory cytokines, free fatty acids,

thapsigargin, and nitric oxide (58-61). Notably, ATF3 is induced by the PERK arm of the ER

stress response, and ATF3 deletion in β cells is protective against apoptosis (59; 60). These

findings highlight the close connection that is likely to exist between ER and GA stress and

suggest that ATF3 may serve as a bridge between these processes. Future studies will be needed

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to delineate the role of ATF3 in GA stress and to test whether changes in ATF3 following GA

stress occur independently of ER stress.

Along these lines, several monogenic syndromes associated with diabetes, are known to

impact β cell function and survival through alterations in ER health, including Wolfram

syndrome, Wolcott-Rallison syndrome, and Mutant INS-gene-induced Diabetes of Youth

(MIDY). Wolfram syndrome is caused by a mutation in WFS1, leading to Ca2+ leakage from the

ER and subsequent ER stress (62). Wolcott-Rallison syndrome is the result of mutations in the

EIF2AK3 gene, which encodes for PERK, and loss of functional PERK induces ER stress,

reduces insulin secretion, and increases β cell death (63). MIDY is a syndrome where mutations

in the INS gene lead to misfolded proinsulin, resulting in ER stress and atypical proinsulin

distribution through the GA (6; 64). Maturity onset diabetes of the young (MODY) subtypes

GCK-MODY and ABCC8-MODY are primarily associated with defects in glucose sensing and

insulin release (65). However, these genes are also expressed in the GA and mutations in these

genes could contribute to GA dysfunction. While rare, the study of preclinical models as well as

tissues from human donors with these monogenic subtypes of diabetes could provide insight into

the mechanisms of GA stress as well as the intersection between ER and GA dysfunction.

In summary, our analysis revealed that multiple GA-associated genes are differentially

expressed in T1D and T2D. Overlapping the T1D and T2D groups with the BFA dataset, we

identified 120 and 204 DEGs, respectively. The higher number of DEGs in T2D may be due to

the different mechanisms by which T1D and T2D develop and suggests that GA stress may be

more prevalent in T2D, but further investigation is needed. In BFA-treated islets, we validated a

signature of GA stress, including ATF3, ARF4, CREB3, and COG6. Several members of the

COG complex were differentially expressed across datasets and thus may be a new target in

Page 19 of 781 Diabetes

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investigations of GA stress. Taken together, our data indicate that GA-associated genes are

dysregulated in diabetes, potentially opening an avenue of research to identify new markers of

GA stress.

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Acknowledgments

Funding. This work was supported by National Institute of Diabetes and Digestive and Kidney

Diseases grants R01 DK093954 and UC4 DK104166 (to C.E.-M.), U.S. Department of Veterans

Affairs Merit Award I01BX001733 (to C.E.-M.), JDRF 2-SRA-2018-493-A-B (to C.E.-M.), and

gifts from the Sigma Beta Sorority, the Ball Brothers Foundation, and the George and Frances

Ball Foundation (to C.E.-M.). R.N.B. was supported by a NIH NIAID Training Grant (T32

AI060519) and by a JDRF Postdoctoral Fellowship (3-PDF-2017-385-A-N). F.S. was supported

by a JDRF postdoctoral fellowship (3-PDF-2016-199-A-N). The funders had no role in study

design, data collection and analysis, decision to publish, or preparation of the manuscript. The

authors acknowledge the support of the Indiana Diabetes Research Center Islet & Physiology

Core (P30 DK097512).

Duality of Interest. The authors declare no conflicts of interest.

Author Contributions. R.N.B. directed the design of the study, the data analysis and

interpretation, the collection and assembly of data, and the writing of the manuscript. O.O., S.T.,

S.S., and P.K. participated in data analysis and interpretation and critical revision of the

manuscript. F.S. participated in data collection and critical revision of the manuscript. H.W.

participated in study conception and design and critical revision of the manuscript. C.E.-M.

directed funding acquisition and study conception and design; participated in the collection and

assembly of data; contributed to data analysis; directed the writing of the manuscript; and gave

final approval of the manuscript. C.E.-M. is the guarantor of this work and, as such, had full

access to all the data in the study and takes responsibility for the integrity of the data and the

accuracy of the data analysis.

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TABLES

Table 1. Summary of Datasets Used for Differential Expression Analysis, Golgi apparatus Filtering, Functional Enrichment, and Pathway Analysis

Dataset GEO Accession Number

Group n Omics Data Type

Profiling Technology

Statistical method in R

Number of probe sets/transcripts for preprocessing

Genes for Differential Expression Analysis

FDR < 0.05 FC (±)

Golgi apparatus– Related Genes Found

1 GSE35296 Ctrl: 5 CTK: 5

RNA-seq Illumina Genome Analyzer II

t-test 35,944 21,192 1.5/1.5 116

2 GSE102371 Ctrl: 3 T1D: 2

RNA-seq Illumina HiSeq 3000

t-test 154,441 21,094 1.5/1.5 122

3 RNA-seq in-house

T1D

Ctrl: 10 CTK: 10

RNA-seq Illumina NextSeq 500

t-test 26,346 26,296 1.5/1.5 408

4 GSE25724 Ctrl: 7 T2D: 6

Microarray Affymetrix Human Genome U113A Array

Limma 22,283 13,515 1.5/1.5 346

5 GSE76896 Ctrl: 116 T2D 55

Microarray Affymetrix Human Genome U133 Plus 2.0

Combat/Limma 54,675 23,520 1.5/1.5 255

6 GSE53949

T2D

Ctrl: 5 Palmitate: 5

RNA-seq Illumina Genome Analyzer II

t-test 41,617 23,071 1.5/1.5 30

7 RNA-seq in-house

BFA Ctrl: 4 BFA: 4

RNA-seq Illumina NovaSeq 6000

Limma 19,168 8,667 1.5/1.5 503

Abbreviations: GEO, Gene Expression Omnibus; FDR, false discovery rate; FC, fold change; T1D, type 1 diabetes; T2D, type 2 diabetes; BFA, brefeldin A.

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Table 2. Human Cadaveric Islet Donor Characteristics

Islet Preparation

Donor ID Age (years)

Sex BMI (kg/m2)

Blood Glucose (mg/dL)

Islet Source

Islet Isolation Center History of

DiabetesRNA-sequencing

1 SAMN11523048 35 F 33.4 137 IIDP Sharp-Lacy No

2 SAMN11514696 59 F 21.8 220 IIDP U. Miami No3 SAMN11982795 54 M 42.8 191.6 IIDP U. Wisconsin No4 SAMN12274306 37 M 25.3 192.8 IIDP U. Miami No

qRT-PCR5 SAMN13836615 58 M 23.2 88.6 IIDP Sharp-Lacy No

6 SAMN13938639 50 F 39.2 131.4 IIDP Southern California ISRC No

7 SAMN13972304 49 M 34.8 161.2 IIDP Southern California ISRC No

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FIGURE LEGENDS

Figure 1. GA-associated genes are differentially expressed in T1D. A. DEG summation from three T1D datasets was overlapped with GA-associated genes, yielding 611 DEGs (FC >1.5, FDR <0.05, p<0.05). B. cnetplot of the top five pathways (182 total pathways) and associated DEGs following use of a more stringent cutoff of DEGs (173 DEGs, FDR <0.01) with the associated functional enrichment and pathway analysis.

Figure 2. GA-associated genes are differentially expressed in T2D. A. DEG summation from three T2D datasets that overlapped with GA-associated genes, yielding 1,013 DEGs (FC >1.5, FDR <0.05, p<0.05). B. cnetplot of the top five pathways (total of 390 pathways) and associated DEGs following use of a more stringent cutoff of DEGs (FDR <0.01) with the associated functional enrichment and pathway analysis.

Figure 3. BFA induces GA-associated genes and pathways in human islets. Human cadaveric donor islets were obtained from the Integrated Islet Distribution Program and treated with 0.1 μg/mL BFA for 24 h (n=4). A. Principal component analysis of BFA-treated and DMSO-treated (control) islets. B. Differential expression analysis yielded 8,667 DEGs (4,289 upregulated & 4,378 downregulated; FC >1.5, FDR <0.05, p<0.05). The top 50 up- and downregulated DEGs are expressed as a volcano plot. C. Functional enrichment revealed 110 pathways significantly different between control and BFA treatment, and the top 5 pathways and associated DEGs are presented as a cnetplot.

Figure 4. GA-associated pathways in BFA-treated human islets. A. DEGs from our BFA-treated dataset were overlapped with known GA-associated genes, yielding 503 DEGs (FC >1.5, FDR <0.05, p<0.05). B. Alluvial plot showing the top five pathways (total 110 pathways) and associated DEGs using a more stringent cutoff of FDR <0.01 (yielding 364 DEGs) followed by functional enrichment and pathway analysis.

Figure 5. Overlap of DEGs between T1D and T2D datasets and BFA-treated human islets. A-B. Total summation DEGs from T1D (A) and T2D (B) datasets were overlapped with DEGs from our BFA-treated dataset. C-D. GA-associated DEGs from T1D (C) and T2D (D) datasets were overlapped with GA-associated DEGs from the BFA dataset. (E) Heatmap visualizing the overlap of 29 GO terms common to the T1D, T2D, and BFA groups following DEG functional enrichment.

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Figure 6. Candidate Golgi stress genes are upregulated in BFA-treated human islets. A-E. Human cadaveric donor islets were obtained from the Integrated Islet Distribution Program and treated with 0.1 μg/mL BFA for 24 h (n=4 from 3 biological donors). qRT-PCR was used to determine the expression of ARF4 (A), ATF3 (B), CREB3 (C), COG6 (D), and GOSR2 (E); *p<0.05.

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T1D T2D BFADataset 1 Dataset 2 Dataset 3 Dataset 4 Dataset 5 Dataset 6 Dataset 7A4GALT AAED1 A4GALT SYBU PCOLCE2 A2M-AS1 ARF4A4GNT AAR2 AAAS MFN1 ARG2 ABI3 CYB5D1AADAT ABCA3 AACS FUT6 ELFN1 ACSL1 ZNF598ABCB1 ABCC8 AADAC HAX1 PRIMA1 ACSL3 MFSD2AABCG4 ABHD10 AADAT TCEA1 RP1-212P9.2ADHFE1 RRP12ABHD14B ABHD15 AAED1 ERO1LB FAIM2 ADI1 HYOU1ABI3BP ABLIM1 AARSD1 AASDHPPT PTPN3 AGK HSPA5ABRACL ABT1 ABCB11 PRDX4 TSHR AGR3 HERPUD1ACE AC007204.2ABCC1 SRP72 RASSF10 AHCYL2 CYCSACKR3 AC007383.3ABCC3 APEX1 CTSV AK8 SLC30A8ACP2 AC019117.2ABCC4 SERBP1 ACOT13 AKAP5 JMJD6ACP6 AC079630.2ABCC5 IAPP RP11-320H14.1AKR1C1 SYVN1ACSBG2 AC090044.1ABCC8 SPCS1 DHRS7 AKR1C2 KIAA0513ACSL4 AC123768.4ABCD3 IARS NDUFS1 ALG9 LZTFL1ACSL5 AC132216.1ABHD12 PSMG1 MRPL18 ALOX15 MYBBP1AACSM3 ACACA ABHD14A STOML2 MYLK3 AMD1 POLR3DACTA2 ACAN ABHD15 UPF3A HCN4 AMT SLC31A1ACVRL1 ACE ABHD16A CDC40 KCNAB2 ANGPTL4 GPT2ADAMTS9 ACOT1 ABHD17B IPO5 ENDOD1 ANKRD13CMAP1LC3BADARB1 ACOT2 ABHD6 ARMCX1 RDH10 ANXA9 C17orf107ADAT3 ACRBP ABI3 DNAJB9 NDUFS4 AOC3 IQSEC2ADCK2 ACTRT3 ABI3BP TM9SF2 HS6ST2 AOC4P ZCCHC7ADH5 ACVR2A ABLIM1 USP1 NTPCR AQP4-AS1 SERP1ADIPOR2 ADAM22 ABLIM2 PDIA6 SLC26A4 AREG MANFADNP2 ADAMTS2 ABLIM3 HSPG2 MPC1 ARFGAP3 NPRL2ADORA2A ADAP2 ABRACL SECTM1 FAM47E /// FAM47E-STBD1 /// STBD1ARHGAP11BSELENOSAGER ADCY2 AC000124.1ACSL1 TMEM37 ARHGDIB SRPRBAGFG2 ADCY5 AC002480.4GPR89A /// GPR89BSDHB ARHGEF11 GOSR2AGO2 ADSSL1 AC004158.2C7orf43 ADH5 ARHGEF28 DPH2AGR3 AGBL4 AC004221.2FNDC3A FTL ARPC1B SUPV3L1AIFM2 AIF1 AC005083.1WDR12 GABRA2 ARRDC4 VOPP1AIMP2 AIG1 AC005152.2UNC50 C11orf87 ASCC3 TBC1D15AKIRIN2 AK9 AC005498.3ARCN1 DQ592442 ATF3 NDEL1AKR1B1 AKAP5 AC005606.14CHMP3 /// RNF103-CHMP3COMMD1 ATP8B3 KDELR2ALAS1 AKIRIN1 AC007092.1MICB MRPS18C B4GALNT1 TIMP2ALDH1B1 AKT3 AC007283.5NMT1 GREM2 BDNF-AS USP36ALDH5A1 AL121761.2AC007383.3SLC28A3 RPA3 BEST1 MSTO1ALG12 AL589765.1AC007389.3PRKCZ SRXN1 BHLHE40 SLC35E1ALKBH1 ALDH5A1 AC007405.6ISOC1 NHLH2 BRCA1 NCDNALPL ALPPL2 AC007773.2FBXL5 EPB41L1 BRD8 NUB1AMHR2 ALS2 AC007879.2CLK1 SMIM13 BRINP2 MPC1AMT ALS2CR11 AC009336.24TMX4 TOMM20 C10orf76 ADAMTS2AMZ2 AMBP AC009495.2CXorf40B TMEM126BC1QTNF1-AS1ZFPL1ANAPC1 AMER2 AC009495.4BCL2L2 PCCB C20orf196 SRP54ANGEL1 AMER3 AC012309.5LSM12 MRPS33 C20orf96 POLR3EANGPTL6 AMIGO1 AC013268.5UBE2D2 LOC101927734C21orf62 CNOT9ANKRD1 AMZ2 AC016722.1CYP3A4 ATP5F1 C22orf39 EPB41L1ANKRD13BANKMY2 AC017002.1SRSF10 ATP6V1H C2CD4A LOC728392

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ANKRD22 ANKRD20A1AC017048.4PCSK1 SLC2A1 C2orf76 FTSJ1ANKRD27 ANKRD20A2AC022007.5MRPL3 B4GALT4 C4B_2 ODF2ANKRD29 ANKRD22 AC022816.2DHX29 CKS1B C8orf33 PGM3ANKRD46 ANKRD39 AC023490.1WDR61 TMEM126AC9orf116 PRNPANO1 ANKRD7 AC069513.4BLOC1S5-TXNDC5 /// TXNDC5PSMC2 CA11 PGAM5ANTXR1 ANXA6 AC069547.1PSMD11 CHODL CA14 PI4K2AANXA3 ANXA7 AC073343.1SEC63 PAICS CAMSAP1 DHDDSAOC1 AP000688.29AC073346.2GPRIN2 PSMA3 CAPN3 NXT1AP1B1 AP000769.7AC074138.3PPM1A PDP2 CBR4 GOLGA3APBA3 APCDD1L AC084018.1COL16A1 GRIN2D CBX3 PHF20L1APLN APH1B AC092171.4PIKFYVE NDUFV2 CCDC102B NOLC1APOH APOB AC093063.3SRSF6 C18orf8 CCDC121 CRIPTAPOOL AQP4 AC093157.1MAPRE1 OSTF1 CCDC150 MAFBAPOPT1 AQP7 AC093375.1PLAGL1 NASP /// NASPCCDC152 BSDC1AQP1 AQPEP AC093850.2UBE2M SMAD9 CCDC34 PNO1AQP7 AREL1 AC096772.6CAMKK2 SNRPD2 CCR1 TMEM41BAQP7P1 ARF5 AC104135.4PPP1CC PGRMC1 CCR5 DNAJA3ARAP1 ARHGAP10AC109826.1G3BP2 NIF3L1 CD247 SEC13ARF5 ARHGAP20AC112229.7TMEM70 LOC148696CD27-AS1 RPGRIP1LARHGAP26ARHGAP36AC115522.3CCDC47 IMP3 CD82 CENPJARHGAP31ARHGEF26AC116407.2LMBRD1 MBNL2 /// MBNL2CDC6 C11orf24ARHGAP39ARHGEF6 AC127496.1HOXA3 FAM193B CDCA8 ATG13ARHGEF10LARIH2OS AC132872.2HSPE1 RAMP3 CDH24 UFM1ARHGEF19 ARL15 AC139426.2TMED10 CHMP2A CEBPG SIAH2ARHGEF28 ARL2BP AC141928.1TMEM251 LONRF3 CELF1 IMP4ARHGEF3 ARL3 AC144831.1GABRP MRPS30 CENPH YRDCARL4C ARNT2 AC147651.3BET1 LSM3 CEP68 SNHG1ARMCX6 ARSI AC156455.1ECI2 PPP1R1A CEP85L NOL6ARR3 ARV1 ACAA2 TOP3A NCKAP5 CETP MAXARRB2 ASAH1 ACACB SEL1L RPL36AL CHAD YTHDF1ARRDC4 ASB8 ACAD10 ANKRD46 TRMT10C CITED2 IFRD1ARSF ASH1L-AS1 ACADL RBP4 SNAPC5 CKAP2 HSPA9ASPN ASL ACADSB MAP3K11 DIAPH2 CMBL ZNF140ASTN2 ASNSD1 ACAP3 TTC19 RRAGD CNN1 OGFOD1ATF7IP2 ASTE1 ACAT1 PEX2 SPAG7 CNNM3 PMM2ATG12 ATG9B ACBD6 ATP5B PELO CNTNAP2 TUBA1AATG13 ATP1A3 ACE TEX261 TAMM41 COL22A1 SRPRAATG2A ATP2A3 ACHE ZNF518A TUBB2B COL6A6 CCDC149ATIC ATP6AP2 ACKR5 GAL3ST4 DGUOK COPG1 NAT9ATP5F1 ATP6V0B ACKR6 LRRFIP1 OPA3 COPS7B TMEM263ATP6V1G2 ATP6V0C ACN9 PFN2 MLLT6 CORO1A ATF6ATRAID ATP6V0D1 ACO1 HMGB1P12 /// HMGB1P12CMAS CPT1A KDELR3ATXN7L3 ATP6V1D ACOT11 SLC25A5 TMEM27 CREB3 RIOX2B3GALNT2 ATP6V1E1 ACOT6 NUCB2 PPCS CREB3L4 HSP90B1B3GNTL1 ATP6V1F ACOT9 ILF2 C14orf119 CRISPLD1 SCGNB4GALNT4 ATP6V1G1 ACOX2 UAP1 METTL5 CSPG4P1Y UBE2BBAALC-AS2ATP8A1 ACP2 MCM3AP IER3 CSRNP1 NARSBAAT ATPAF1 ACPP CCL5 C11orf73 CTNNA3 ATF3BACE1 ATXN1 ACSL5 DAP PRR26 CTNNBIP1 COQ10BBACH1 AVPR1B ACSL6 MBD1 LOC102724814CTSF OSBPL2

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BAP1 B3GALT4 ACSS1 EEF1A1 TWF1 CTSZ ATG101BATF3 BACE1 ACTBL2 AHCY SOD1 CXCL1 BET1LBBS2 BAG5 ACTR1B PIGT PRR13 CXCL8 SELENOKBCAM BANK1 ACTR3 SLC35B1 MRPS23 CYP26B1 DNAL1BCDIN3D BAZ1A ACTR5 CEND1 ATP5O DDIT3 RALABCL6 BBS4 ACTR8 SLC9A6 RAB30 DENND6B ARMCX1BCOR BCAR3 ADAM20 CSNK2B EIF2B3 DEPDC7 KDM6BBDKRB1 BCAS2 ADAM33 C5orf22 DKK3 DLGAP1-AS1EFR3BBEST1 BCHE ADAMTS1 CREB3L1 YPEL1 DNASE1 PNPLA8BFSP1 BCL7B ADAMTS4 EMC2 UTP11L DPRXP4 CEP70BHLHE41 BCL9 ADAMTS9 FZD9 CCT4 DPY19L2P2TMEM39ABID BCLAF1 ADAMTSL2VPS53 LINC01116 DRICH1 FARSABIRC3 BEND5 ADAR NELFCD SLIRP DUSP1 NRBF2BLCAP BEST1 ADCK1 SGCE NDUFS5 /// RPL10DUSP5 TMEM248BLMH BEX2 ADCY1 EXOC1 TSPAN1 DYNLRB2 OXNAD1BMP4 BEX4 ADCY7 USO1 MDH1 E2F7 ZNF395BNIP3L BEX5 ADH1B AKAP11 HNRNPA0 ECM2 TOP3ABPGM BLCAP ADH5 TMC6 INPP5D ECT2L ORMDL3BRCC3 BLOC1S2 ADH6 PLCB3 CCT2 EDA SCFD2BRD4 BMP8A ADM MYH14 TTI2 EDEM1 RBKSBRWD3 BRAP ADORA1 TMX1 LRTM1 EDEM2 TMCO1BSCL2 BRMS1L ADORA2A TNFRSF14 SCO1 EDN2 PCNX3BTBD9 BRWD1 ADPRH DCTN6 COX11 ELMOD3 NQO1BTN2A2 BTBD3 ADPRHL1 IKBKAP SNX11 ELMSAN1 GOT1C11orf53 BTBD6 ADPRHL2 XPOT GCC1 EMX1 ALKBH5C11orf71 BTN3A2 ADRA1B UBE2E3 ANKRD20A12P /// LOC101059949 /// LOC101060632 /// LOC101927345ENPEP POLE3C12orf60 BX088651.1ADRA2A ZNHIT3 KIAA1045 ENTPD3-AS1MNTC12orf75 C10orf107 ADRA2C NSMAF ATP5H EPDR1 INTS6C14orf105 C10orf95 ADTRP CACNB1 TMEM60 ERMAP RASSF1C14orf169 C11orf1 AF064858.8GALC TMEM59L ETV5 SCD5C15orf41 C11orf70 AFAP1L1 PTGES3 EFTUD1 EZH1 BLZF1C15orf48 C12orf23 AFG3L2 BEX4 PSMA1 F2R ISG20L2C1orf116 C12orf76 AGO1 ZNHIT6 MED27 FADD COASYC1orf162 C14orf182 AGPAT3 PTS RPL26L1 FAM134C GOLGA5C1QTNF1 C14orf28 AGT ZFAND1 APOO FAM182A GSNC1QTNF3 C15ORF37 AHCY GTF3C3 ODC1 FANCD2OSZNF608C1QTNF6 C15orf40 AIG1 OXSM SPTLC3 FARP2 BMFC1R C16orf87 AIM2 MIS12 MYOM1 FBXO24 UCHL5C1S C17orf100 AK4 MBD3 POLR3K FCMR GNL2C20orf96 C17orf104 AKAP7 GOLGA5 TACC2 FDX1 NEURL4C21orf62 C17orf105 AKIP1 GTSE1 FAM71C FEZ1 HCG18C21orf62-AS1C17orf82 AKIRIN2 CCNF MICAL1 FGF14-IT1 MAP1AC22orf39 C1D AKR1B10 IPO4 /// TM9SF1TUBA1B FGF2 BCAS2C2CD2L C1orf112 AKR1C2 KDELR2 ANKRD46 /// GAPDHP62FICD EIF2S3C2orf44 C1orf132 AKR1C3 ZNF358 PTPRU FKBP6 LAPTM4BC2orf74 C1orf233 AKR1C4 PRPS1 DBI FKBP7 COG6C3orf18 C1orf52 AKR7A2 CRKL RIMKLA FOS DNAJC25C3orf67 C1orf74 AKR7A3 UNC119B KIRREL3 FUNDC1 DDX50C4orf3 C1QB AL009178.1HAT1 PLA2G16 G6PD TMEM104C5orf28 C1QC AL031666.2SUCO CRHBP GALNT15 TSN

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C6 C1QL1 AL035610.1TSPY1 CXXC5 GAS6-AS2 SRA1C6orf106 C20orf112AL132709.5MIR6872 /// SEMA3BAP5M1 GATS SEC16AC6orf223 C21orf119AL162759.1ALG5 PROCR GCLC SCYL1C8orf59 C22orf26 AL355149.2SF3B1 PRKCD GCLM ENGC9orf9 C2orf70 AL357673.1PIK3R4 PBDC1 GDF5 ANGPTL2CA8 C3orf14 AL626787.1SRSF7 TNFRSF21 GEMIN7 SDC2CABLES1 C3orf18 ALAD MKRN2 LOC100506411GEMIN8 GZF1CAD C3orf33 ALAS2 DCTD MRPL1 GJB2 TPMTCALHM2 C3orf67 ALDH1B1 SRSF8 BOLA3 GK GNL3CALML4 C3orf83 ALDH3A2 LOC101060321 /// LOC101060351 /// LOC101060376 /// LOC101060389 /// LOC102723859 /// LOC102724862 /// TBC1D3 /// TBC1D3C /// TBC1D3F /// TBC1D3HDARS2 GNGT2 PPP1R11CARHSP1 C5AR1 ALDH3B1 MLH1 PPP2R5A GNL2 ETF1CASP5 C5orf55 ALDH4A1 ITGB4 EFCAB11 GNL3 GDACASP6 C6orf57 ALDH5A1 DLD LOC102725454GOSR2 LINC02693CASP7 C7orf55 ALDH7A1 PSMD6 FFAR4 GP6 TCF4CATSPER3 C7orf73 ALKBH3 DESI2 TIMM8B GPAT3 ATAD3ACBX1 C8A ALKBH4 FGF16 ARPC1A GPR3 ALDH18A1CC2D2A C8orf4 ALKBH7 RSL1D1 MRPL47 GPSM3 CREB3CCDC102B C9orf72 ALMS1 TRMT5 ABRACL GRAMD3 GPR107CCDC112 C9orf91 ALOX5AP NUP37 NOD1 GRM3 TARSL2CCDC113 CACNA1B ALPK1 DDX46 PSMB7 GTF2H5 XPNPEP3CCDC117 CACNG4 AMBP ERC1 SATB1 GTF2I SGTACCDC121 CALB1 AMER1 GUCA2A GOT1 GTF2IP4 BRIX1CCDC142 CALD1 AMHR2 SH3PXD2A SLC9A3R1 GTF2IRD1P1SENP2CCDC152 CALHM1 AMIGO1 L1CAM DHRS7B GTPBP2 C2CD2LCCDC189 CALHM3 AMIGO2 RPE /// RPEL1RHBDL3 GZMB GON7CCDC191 CAMK2D AMOT METAP2 TCEB1 H2AFB1 DDX42CCDC34 CAPN1 AMPD2 POP7 EMC3 HAUS1 FAM8A1CCDC43 CAPN13 AMPD3 CXorf40A CHTOP HIST1H2ACGCC2CCDC6 CAPN14 AMT EDEM1 CCT8 HLA-DMA SIKE1CCL2 CAPN7 ANAPC4 CAPN7 CATIP-AS1 HLA-DMB CENPNCCND2 CARTPT ANAPC5 RABGGTB FGFR2 HLA-DPA1 SLC35A2CCNI CASC19 ANGPTL1 MUC3B PSMC1 HLA-DPB2 TMEM120BCCNK CASP3 ANGPTL6 C18orf32 /// RPL17 /// RPL17-C18orf32 /// SNORD58A /// SNORD58B /// SNORD58CFASTKD5 HLA-DRA YIF1ACD209 CASP8 ANKH TUBG1 MRPS36 HNRNPUL2-BSCL2TULP3CD247 CBLN1 ANKRD1 ANAPC13 MRPS22 HSD3B1 GORASP2CD300LF CCDC176 ANKRD11 USP16 CCDC167 HSPA5 TPD52L2CD302 CCL26 ANKRD13AFAM179B ALS2CR11 HYKK IPPKCD40 CCL3L3 ANKRD13DPPIP5K2 MDH2 IARS PPP2R5BCD7 CCNT2 ANKRD16 SCUBE3 SERPINB8 IER3 LONP1CD82 CCSAP ANKRD18ATMEM50A ATP1B3 IFT74 SEC63CDC16 CD22 ANKRD22 PAICS EIF4A3 IGDCC4 STK19CDC25B CD247 ANKRD34ARIN3 LACTB2 IGFBP1 BBOF1CDC5L CD302 ANKRD35 NECAP1 LOC100507654IGFBP6 SF3A3CDCP1 CD36 ANKRD39 SERPINI1 MARS2 IL1RN SMPD4CDH24 CD48 ANKRD42 HMGN2 FH IL5RA NOL7CDK8 CD97 ANKRD6 NME7 NDUFB9 IL6 CABP7CDKL2 CDA ANKRD65 TOMM20 NSMCE2 IMMP2L DERL1CDKN2AIPNLCDC14B ANKS3 TMX2 PDCD10 IMPG1 GTF2F1CDX1 CDK17 ANO2 MAST4 AKT1 ING5 STX5CELF5 CDKL2 ANO8 M6PR /// PHC1PIGH INTS3 AKAP17A

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CENPBD1P1CDO1 ANP32E CST8 NDUFB6 IQCB1 POFUT2CENPH CENPC ANXA13 SDHD ZBTB8OS ITIH1 BAG5CEP104 CEP85L ANXA4 ATP6V1A BTBD10 JMJD7 MPHOSPH10CEP290 CERK ANXA6 ENPP2 EAF2 KANSL1 SELENONCEP57L1 CFB ANXA9 AP2M1 MRPL14 KCNJ1 E2F4CEP68 CFTR AP000349.1XBP1 TBC1D5 KCNJ10 SLC25A38CEP85 CGRRF1 AP000439.3SYN3 MPHOSPH10KCTD2 ZNF263CFAP126 CHADL AP000654.4CUL1 TARS KIAA0101 RTL10CFDP1 CHCHD2 AP000769.7PEX3 NCBP2-AS2KIF15 CDK2AP2CFI CHD9 AP001372.2KLHDC2 NOTUM KLKB1 TMX2CGB7 CHGB AP006222.2LMNA SEPT8 KMT2E-AS1STC2CGREF1 CHRM4 AP3B1 NDFIP1 CMSS1 KNG1 CHD3CHAD CHRNA4 AP3S1 KLHL18 UBQLN1 LAMP3 SRP72CHAMP1 CHST9 AP5B1 SDC2 BC069776 LCP2 DPP9CHCHD4 CKMT1B AP5Z1 C5orf28 PSMB6 LEAP2 ST5CHGA CLEC14A APBA1 SLBP MFAP3 LGI1 ZNF550CHI3L2 CLIP4 APCDD1 DTX4 GPN3 LHFPL3-AS1TAF13CISH CLLU1 APEX1 TJP3 RPL7L1 LIAS EAF2CLDN15 CLLU1OS APOA1BP TGFBR2 SMIM4 LIF ERP44CLDN9 CLPS APOBEC3DOR2C1 LCN10 LIG1 SENP5CLIC3 CLPSL2 APOBEC3F EED MIR4657 /// PURBLILRA1 JMYCLINT1 CMBL APOBEC3GSEP15 PSMD1 LILRA2 RPP14CLNS1A CNDP2 APOC4-APOC2SEC23B PI4K2A LILRA3 UBFD1CLPTM1L CNEP1R1 APOL1 PODNL1 UBE2T LILRB2 TIMP3CLU CNGA4 APOL2 PJA2 ATP5G3 LINC00312 RAD1CLUL1 CNTFR APOL3 RBM23 RAPGEF3 LINC00511 GARSCMBL CNTN4 APOL4 TXNDC15 HRK LINC00693 MED10CMC4 CNTN5 APOPT1 BRD4 MGEA5 LINC00885 PCDHGC3CMTM7 COPS3 APPL2 HDDC2 ESYT1 LINC00899 WDR55CNDP1 COPS7A AQP1 PDGFB PRDM4 LINC00933 WARSCNGB1 COQ10B AQP12B SCGN ATIC LINC00958 CEACAM1CNN1 CORO2A AQP5 INTS12 FTH1 LINC00964 ZNF70CNNM3 CP AQP9 COPZ1 RECK LINC01091 COPACNNM4 CPA1 ARAP1 EPRS ANKRD20A1 /// ANKRD20A11P /// ANKRD20A2 /// ANKRD20A3 /// ANKRD20A4 /// ANKRD20A5P /// ANKRD20A9P /// LOC102723891 /// LOC102725051LINC01140 WNT4CNOT10 CPB1 ARAP2 CUL3 EBNA1BP2 /// MIR6733LIPA DEDD2CNPY1 CPQ ARF5 HPRT1 ALDH1A1 LOC100130899SETD1ACNPY4 CRABP2 ARF6 PTPN3 NDUFS3 /// PTPMT1LOC100289230FAM177A1CNTNAP2 CRAMP1L ARHGAP10DMXL1 BMS1P17 /// BMS1P18LOC158435ZNF229COA4 CRISPLD1 ARHGAP26CNBP NCAPG2 LOC283038SKIV2LCOBL CRY1 ARHGAP31HTR4 ADAMTS17LOC389641CDR2COG2 CSPG5 ARHGDIB SEMA7A GTF2B LOC728024WIPI1COL12A1 CTA-221G9.7ARHGDIG ZAP70 ARCN1 LOC93622 GOSR1COL15A1 CTB-43E15.3ARHGEF17 CPNE3 TIMM10 LOH12CR2 P4HBCOL1A1 CTC-332L22.1ARHGEF35 TFR2 ATP6V1E1 LPCAT4 ZNF462COL1A2 CTC-360G5.9ARHGEF4 RAB1A MCUR1 LRP8 GAKCOL22A1 CTC-534A2.2ARHGEF5 PPP1R12A MAK16 LTBP2 TRIM24COL4A1 CTD-2003C8.2ARHGEF9 MAGEA10 MKRN2 MADCAM1CEP104COL4A2 CTD-2037K23.2ARID5A SLMO2 PTTG1 MAFF JADE2COL6A6 CTD-2186M15.3ARL16 PGRMC2 RAD51C MAP2 PPRC1COPE CTD-2207P18.1ARL4C NAP1L2 MRPL51 /// SPTLC1MAP3K3 HERC6

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COPRS CTD-2526A2.2ARL5B ASF1A C21orf59 MED18 DCUN1D5COQ10A CTD-2651B20.1ARL9 SERPINB13ACVR2B METTL1 PPP1R15ACOX18 CTD-3220F14.1ARMCX5 PLEKHA4 SLC25A33 MFHAS1 KPNB1CP CTRC ARNTL2 SELT LZIC MGAT2 PSMC4CPT2 CYB5R1 ARRDC3 CALCOCO2 POLR2K MIR497HG TOX4CPXM1 CYFIP2 ARSE ARFGEF2 FANCM MKRN2OS COTL1CREBBP CYP4F12 ARSG SUCLA2 CWC15 MKS1 METTL7ACRHR1 CYP4F3 ARSJ SUCLG2 PPP4R1L /// PPP4R1LMMP19 PCMT1CRIP3 CYTH3 ARSK RBBP4 TUBA1C MMP23B SAR1ACRLF1 CYYR1 ART3 UBL3 ENPP3 MNS1 CHST11CROCC DACH1 ARTN RPL6 TPH1 MOXD1 BAP1CROCCP2 DACH2 ARV1 UBR7 CCT5 MPZ GOLGA2CROT DAGLA AS3MT OR10H1 RBBP8 MRO VPS53CSF1 DAXX ASAH1 SSR1 PSMG1 MRPL36 PDX1CSF2 DCDC1 ASB1 APBA2 TRAPPC2L MRPL44 ELP2CSF3 DCK ASB2 PPP2CB LINC00328 MSRA SLC30A7CSTB DCSTAMP ASB4 RFC3 NDUFAB1 MSS51 TMEM131LCTBP1-AS2 DCTN3 ASB9 NPTN KLC1 MTCL1 SLC10A7CTGF DDA1 ASIC3 VDAC1 LOC102723927MTHFSD DNAJC3CTHRC1 DDX23 ASPHD2 CRY1 SCCPDH MTRF1L CEP95CTNNBIP1 DEF6 ASTN2 ERN2 TRNP1 MUC20 IFT20CTPS2 DEGS1 ATAD3C RND2 NBPF10 /// NBPF12 /// NBPF14 /// NBPF15 /// NBPF20 /// NBPF8 /// NBPF9MYOZ1 SLC39A7CTSC DGCR2 ATF3 PGRMC1 E2F3 NANOS2 SLC4A8CTSF DHX35 ATF7IP2 PEX11B NPIPA1 /// NPIPA5 /// NPIPB15 /// NPIPB3 /// NPIPB6 /// PDXDC2PNANS ZFAND2ACTSLP2 DIAPH1 ATG4C CAT CENPN NAPEPLD DPAGT1CTSV DIO1 ATL1 TTC37 LOC340090NAPSA FGFR1OPCTSZ DLEU2L ATP11C NT5M MCHR1 NCAM2 CALCOCO1CUL4A DMTN ATP13A4 DHRS7B RTCB NCF4 ALDH1L2CWF19L2 DMWD ATP1A1 BCL2L13 ZCCHC17 NCKAP1L SRRTCXCL1 DMXL1 ATP1A3 PRKACA NANP NCKAP5 TIMM44CXCL2 DNAH12 ATP1B1 SARS VARS2 NCSTN IRGQCXCL3 DNAH5 ATP1B2 SAR1A ZNF770 NDEL1 ZNF331CXCL8 DNAH6 ATP2B3 UCHL1 LOC102724985 /// PDXDC1 /// PDXDC2PNEK4 PITHD1CXorf40A DNAJB6 ATP4A RSL24D1 ARL2BP NIPAL3 DESI1CXorf40B DNAJC18 ATP5C1 ANP32E DNTTIP2 NIPSNAP1 ZNF37ACYB561D2 DNAJC27 ATP5D SRPR FUT11 NMNAT3 SNNCYB5R2 DNTTIP2 ATP5G2 SBF1 UCHL3 NOP9 NAA35CYB5RL DOCK11 ATP5I SEH1L NBPF10 /// NBPF11 /// NBPF8NPHP1 HM13CYP24A1 DPEP1 ATP5L TMED2 ACVR1B NPM3 MAFACYP26B1 DPP6 ATP5O ARGLU1 IRGQ NPPA-AS1 KLHDC10CYP2R1 DPPA3 ATP6AP1 KLHL28 TXNDC11 NPTXR ZNF622CYP39A1 DRP2 ATP6V0B SMC3 C10orf10 NR2C2AP TOMM5CYP46A1 DSCAM ATP6V1B2 CX3CL1 CCNH NR4A2 EBLN3PCYSRT1 DSCR8 ATP6V1H MARS /// MIR6758DBP NRADDP GJD2DAAM1 DTWD1 ATP8B1 PSMB5 TSN NRBF2 GCC1DALRD3 DUSP12 ATPAF2 FANCC PON1 NREP TCAF1DBNL DYNC2LI1 ATPIF1 SH2B2 LOC100506076 /// LOC100506123NRN1L LLGL2DBP DZIP3 ATXN2 NUDT7 DENR NRROS TRIM27DCAF17 E2F6 AUNIP ZNF343 PPIH ODC1 ZNF791DCAF4 ECSIT AURKB DVL1 PTGR1 ODF3L2 SAR1B

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DCAKD EFCAB2 B2M ZNF22 ATP6V1A OR13J1 FXR2DCLK3 EFCAB4B B3GALNT1 IGF2BP2 PHACTR1 OR51E2 ZSCAN12P1DCST1 EFS B3GALT2 ARFGAP3 CCDC136 ORC6 SBDSP1DCXR EGF B3GAT3 SRPRB REXO2 OSCP1 ALG5DDR1 EHD2 B3GNT1 MAP2K4 DDIT3 P2RY13 MEN1DDX20 EID2 B3GNT2 C11orf58 VTI1B P2RY8 PLEKHG3DDX42 EID2B B3GNT8 SSTR3 NDUFAF2 PAGE2 NDRG1DDX51 EID3 B3GNT9 MON2 TMEM135 PAQR7 RECQL4DEAF1 EIF1AD B4GALNT2 PRKRA ZNF823 PATZ1 UBIAD1DEFB109P1EIF3J-AS1 B4GALNT4 PLEKHF1 LINC00493 PBX2 DNTTIP1DEFB4A EIF4EBP1 B4GALT1 FGF17 PCDH10 PBXIP1 ARL1DEPDC7 EIF5A2 B4GALT5 IL3RA TMEM181 PCBP1-AS1RASSF5DHRS4-AS1EMC4 B9D2 ERH LOC100132207PCED1A ATF4DIAPH2 ENPP5 BAALC ENPP4 NTN1 PCNA ZNF131DICER1-AS1EPG5 BAAT SLC35G2 ABCD2 PCOLCE-AS1DNAJB11DIMT1 EPHA3 BACH1 GRIN1 PRDX1 PEX19 LARP1BDIS3L EPM2AIP1 BAG1 DCK TUBB3 PGAP3 ACVR1BDISP1 EPO BAIAP2L1 KIFC1 CCNB1 PGM3 PNPLA2DIXDC1 ERMAP BAK1 CCT4 IGK /// IGKCPGM5 HSP90B2PDKC1 EXOC8 BANK1 LOC101928278SYNJ2BP /// SYNJ2BP-COX16PIFO DDX21DKFZp779M0652EXOSC5 BATF2 ARPC1A PSMD8 PIGA ATP6V0E1DLEU1 EXPH5 BATF3 ZNF473 EXOC8 PIGV NOCTDLGAP1-AS1EYS BAZ1A DHX15 CLEC4F PIK3C2B DCAF13DMGDH F2R BAZ2A WFDC2 NMNAT1 PIP5K1A GPD1DMKN FAM104A BBC3 PSMA1 FAM20B PITPNC1 AFTPHDMRTA1 FAM105A BBIP1 RNF113A SENP7 PITRM1 TUSC2DNAAF2 FAM124B BBS7 TAF2 SSBP1 PITRM1-AS1ARIH2DNMT3B FAM127C BCAM RPS2 /// SNORA64PSMC3 PLCB2 ETV5DOCK4 FAM150A BCAR1 LARP1 ICT1 PLEKHG4B SLC37A3DOPEY2 FAM159B BCAT2 EPX COX6B1 PLIN2 CUEDC1DPH5 FAM162A BCHE RPL4 /// SNORD16 /// SNORD18A /// SNORD18B /// SNORD18CBLVRA PMM2 IKBIPDPY19L2 FAM163A BCKDHB PDCD10 PSMA5 POLDIP3 SMYD5DPY19L2P1FAM166B BCL10 PFKM USP49 POU2F3 MOGSDPY19L3 FAM167A BCL2 MRPL22 DYRK2 PPP1R15A RPS6KC1DSEL FAM168B BCL2A1 CHUK CTCF PPP1R26 FARSBDSTYK FAM171A2BCL2L14 ALMS1 RAB5C PPP1R32 ELMO1DTX2P1-UPK3BP1-PMS2P11FAM181B BCL3 RPL10A SVIP PPT2 RIN2DUSP10 FAM19A4 BCL6 GORASP2 PSME1 PRSS56 NADK2DYNC2LI1 FAM200B BCL7C SHOC2 MKKS PSMA3 SART1DYX1C1 FAM210B BCL9L PCBP4 DYRK3 PSMC4 FNTAEARS2 FAM212B BCO2 E2F1 PROC PTCD2 SLC7A6EBI3 FAM215A BDKRB1 LILRA4 N4BP2L1 PTGER1 WDR45BEBPL FAM21A BDKRB2 ACP1 G6PD PTGS2 ABLIM1ECEL1 FAM222A BEST1 NEBL SMIM12 PXMP4 PYCR1ECHDC1 FAM229B BEST3 BAG2 FAM19A4 R3HDM2 RBM28ECI2 FAM46C BEST4 PNMA2 SUMF2 RALBP1 CBX4EDA2R FAM53B BEX4 LOC732360 /// TDGENO1 RANBP10 PYGBEDN2 FAM66E BHLHE41 MPC2 MIR101-1 /// MIR3671RAPGEF3 ROCK1P1EDRF1 FAM72B BICC1 PEF1 SRRM2 RARRES3 FICDEFCAB7 FAM76A BIN3 RPS6KC1 PTRH2 RASL11B SBDS

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EFEMP1 FAM76B BIRC3 RECQL4 NEU1 RASSF1 IL20RAEHHADH FAM8A1 BIRC5 RRAGA FBXO45 RBBP8 ZNF165EIF2AK4 FAM90A1 BIRC7 RALGAPA1 /// RALGAPA1PKIAA0391 /// PSMA6RBM14 CCNKEIF4A2 FAM92A1 BLMH RNU86 /// RPL3 /// SNORD83BMRPL15 RHOB PPIEEIF4EBP3 FASTKD3 BLNK RWDD2A CAPS RNF135 MBD1EIF4G3 FAXC BLZF1 SERP1 PSMA7 RNF223 SLC2A4RGELK4 FBXL14 BMP2 SCP2 TP53INP2 RORC C6orf62ELMSAN1 FBXL5 BMP4 SRP54 SEC16B RPARP-AS1PLVAPEMC3 FBXO10 BPGM AZIN1 MTUS2-AS1RSPH14 HYAL2EMC7 FBXO11 BPHL VLDLR EIF2S2 RTTN MAATS1EMP1 FBXO27 BPIFA1 CLTCL1 ZNF189 SDHC USP48EMP3 FBXO43 BRD4 ARVCF TUBB2A SEC23B SEC22AENC1 FBXO7 BSPRY ZDHHC4 MKNK1 SEC24B-AS1ARL2BPENDOD1 FBXW7 BST2 RHOA CHKB-CPT1B /// CPT1BSEC31B OLFM2ENO3 FCGR1B BTBD2 AMZ2 MB21D2 SEC61A1 ETV1ENPP5 FEM1A BTBD6 TEX2 ATP6V1B2 SEMA4D EBPLENTPD2 FFAR1 BTG1 DNASE2 MRPL36 SEPP1 STX18EPAS1 FGF14-AS2 BTN2A1 CENPC ID1 SEPSECS-AS1CCDC9EPB41L1 FGF14-IT1 BTN2A2 CPE NPM3 SERPINA7 ASCC2EPB41L4A FHAD1 BTN3A1 CCDC15 NPIPA5 /// NPIPB3 /// NPIPB6 /// NPIPB8SH2D4B AP3D1EPDR1 FHOD3 BTN3A2 TFB2M AC004538.3 /// BC040327SHH DUSP12EPHX2 FKBP5 BTN3A3 PHB GREM1 SIGLEC10 CNPEPOR FLII BTNL8 FAM208B FLJ11292 SIRT1 RAB18EPS8L3 FLT4 BUD31 RAD54L LOC101928669 /// LOC644450SLAMF7 ESCO1ERAP1 FMNL2 BX088651.1PRDX3 NUS1 SLC15A3 ATG4AERI2 FOCAD BZW2 TMEM14B RTFDC1 SLC1A3 TTC17ERO1A FOXO6 C10orf128 PRPSAP2 MRPL21 SLC22A18ASSEC61A1ESYT1 FOXRED2 C10orf32 RAB6A /// WTH3DIDNAJC8 SLC25A20 CAMLGETV3 FRZB C11orf1 EAPP TIMM8A SLC25A21-AS1MAF1EXD2 FSBP C11orf24 ERGIC2 ANKRD53 SLC26A7 STK40EXOC3L4 FSIP2 C11orf31 RBM7 CELF5 SLC33A1 TRMT6EXOSC8 FTH1 C11orf74 RBM39 LOC399491SLC35E2 HLA-EEYA2 GABARAPL1C11orf83 KATNB1 OSGIN2 SLC46A3 YPEL4EZH1 GABPB2 C11orf92 SNX24 RP11-490G2.2SLC7A11 PRKAR2AF12 GANC C11orf93 RHEB CACYBP SLC7A5P1 SAE1F2R GATA4 C11orf95 PYY2 HSPE1 SLC7A5P2 ZNF222FAAH GATS C12orf10 TNFRSF13BSAGE1 SMARCD3 SEC23IPFAM104B GBA C12orf74 PSMC3 PDCD5 SNHG1 AENFAM110B GC C12orf75 KIR3DS1 GRM1 SNRPA1 ZNF587FAM110C GCH1 C14orf105 TVP23B PBXIP1 SNX20 ATP2A3FAM117B GDF11 C14orf37 CUL5 NDUFAF4 SPAG8 RNF40FAM120B GFOD1 C14orf80 ADSS MZT1 SPATA17 ELOVL5FAM122C GGA2 C14orf93 ZNF646 UQCR10 SPATA32 DCUN1D3FAM133CPGINS2 C15orf27 SDHB PPM1N SPEF2 L3MBTL2FAM136A GJA3 C15orf48 HAUS2 FAM162A SPIRE1 ATXN7L3FAM156A GJD2 C15orf52 CYP2C8 TMEM65 SPRED2 LSAMPFAM168A GJD3 C15orf54 LOC101928747 /// RBMX /// SNORD61C14orf37 SQSTM1 CEP76FAM172A GLP2R C15orf59 CYC1 MRPL13 SRP14-AS1 COG1FAM182B GLT8D2 C16orf46 TNNI2 IGKC SSTR5-AS1 ZXDCFAM198B GNA12 C16orf59 GJC2 ACTRT3 ST3GAL4-AS1PLCG1

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FAM19A4 GNAI1 C16orf80 OSTM1 PLGLB1 /// PLGLB2STAC3 EDC3FAM217B GNAI2 C16orf95 TBPL1 SNRPD1 STARD4-AS1UBTFFAM220A GNAO1 C17orf76-AS1DCAF15 CENPW STC2 ANKRD42FAM24B GNG10 C17orf89 CRYBB3 IQGAP1 STPG1 RELAFAM35A GNG5 C17orf96 ENOPH1 TECPR1 STX6 FAM160A2FAM53B GOLGA6C C18orf32 PSMB7 RNASEH1 SUFU TFGFAM66A GOLGA8G C18orf8 CLNS1A TUBB SUMF2 SHMT2FAM86B1 GOLGA8M C19orf48 NUP205 GLO1 SUMO1P1 LOC107105282FAM86DP GPCPD1 C19orf66 SIGLEC7 SNRPB2 SUN1 MEIS1FAM95B1 GPM6A C1GALT1C1FBL LINC00475 SUV39H1 H3F3AP4FARP2 GPR113 C1orf127 MFF SMAD7 SYNGR1 KRT10FBLN1 GPR119 C1orf158 PRKAG1 TFRC TBC1D13 SCML1FCAMR GPR125 C1orf159 SUN1 TUBB4B TBL2 FBXO25FCER2 GPR142 C1orf192 PCNP TMEM242 TCTEX1D2 VWA1FCMR GPR150 C1orf198 POU5F1 /// POU5F1B /// POU5F1P3 /// POU5F1P4HAT1 TFDP2 WDR24FDXR GPR157 C1orf204 MUSK PANX1 TGM1 ACBD3FERMT3 GPR27 C1orf213 C5orf66 LINC00621 TMCO3 ARHGEF3FEZ1 GPR52 C1orf227 HCRP1 CLDN12 TMEM147-AS1ACLYFGF11 GPR64 C1orf229 DNAAF1 DBH-AS1 TMEM218 RHOQFGF2 GPR75 C1orf233 CMKLR1 AP1AR TMEM39A TBC1D24FGF9 GPR98 C1orf35 HNRNPH3 PARS2 TMEM8B QRICH1FGR GPT2 C1orf50 MAPRE3 COX17 /// POPDC2TMEM91 UBA5FHOD1 GRB10 C1orf61 CNIH1 PSMC4 TOB1-AS1 MMRN1FHOD3 GRHL2 C1orf85 WIPF1 FLJ38379 TOLLIP-AS1CWC25FIBIN GRK4 C1QB HMGCR LOC692247TP53TG3C ZNF526FKBP10 GSE1 C1QL4 MPP6 HSPBAP1 TPTE2 CXXC5FKBP7 GTF2A2 C1QTNF1 FKBP10 RFC5 TPTE2P5 UBR7FKBP9 GTF3C4 C1QTNF5 CCNG1 ENOX2 TRIM16 POLR3AFKBP9P1 GYG1 C1R LETMD1 KCNN3 TRIM16L TRMT1FLJ16779 GYS2 C1RL EMC7 SNRPD3 TRMT6 YY1FLNC GZF1 C1S CALU HLA-DPB2 TRPV3 RAB5AFLT3LG H2AFV C20orf112 AIPL1 SEC23B TSC22D2 TGDSFMO1 H2AFY C20orf141 RNGTT LOC101928519TTC31 ZNRD2FMO3 HACE1 C20orf195 PPP3CC TUBG1 TTC32 CD82FNDC3B HBA1 C20orf197RPL7A /// SNORD24 /// SNORD36A /// SNORD36BLOC101927359TTC39B BMP5FOLR1 HBA2 C20orf27 PCDH1 MTMR9LP TTC41P POLR2CFOXJ2 HCN4 C21orf33 DHRS7 POU6F2 TUBB6 ANP32AFOXO1 HDGFRP3 C22orf29 CKLF MIR133A1HGTXNRD1 LINC00261FREM1 HDHD1 C2CD4A SCG5 GOLGA6L4 /// GOLGA6L5P /// GOLGA6L9 /// LOC102724093UAP1 CNOT10FRMD3 HEPACAM2C2CD4B TMEM135 LSM2 UBXN8 DPH7FRZB HERC3 C2CD4D FAM106A COL27A1 VCP SLC30A5FSCN1 HEY1 C2orf27B ZZZ3 EGFEM1P VPS37D ACP1FUCA2 HHAT C2orf72 IRF7 PTPN11 VPS52 INPP5KFUK HIGD1B C2orf81 NDUFB8 NDUFB3 VTI1A FAM156BFUNDC1 HIST3H2A C2orf88 CREG1 ADSL WARS NOC4LFUOM HLA-DMB C3orf18 SLC25A11 RAB21 WASH5P MAGOHFUT1 HLA-DRA C3orf38 PRIM1 ZNF259P1 /// ZPR1WDR63 MTORFZD1 HLA-G C4orf19 NME1 SF3B5 WDR88 EIF2AK3G0S2 HLF C4orf27 PGD FRAS1 XPC ZNF384G6PC2 HOPX C4orf32 LTN1 CYCS YWHAH ELMSAN1

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G6PD HOXA1 C5 PPP2CA EXOC6 ZBED5-AS1ZNF805GABRE HOXB2 C5orf15 ME2 RFC4 ZBTB21 STT3AGADD45A HOXB3 C5orf27 MTPAP FLJ33534 ZBTB49 SMAD7GALNS HOXD3 C5orf30 CYP21A1P /// CYP21A2DYNLT3 ZCCHC4 GRPEL2GALNT12 HPCAL1 C5orf46 GNAS RP11-182L21.5ZMYM3 WDR74GALNT4 HPD C5orf56 COPA COX7B ZNF135 SEL1LGAMT HPDL C5orf63 TAS2R9 ZNF106 ZNF165 ESRP1GAPDH HPSE C6orf106 RPL7 DERA ZNF205-AS1DCAF10GAS1 HRH4 C6orf123 OAT CKB ZNF252P-AS1CHD1GATAD1 HRNR C6orf136 MTMR6 PGD ZNF280A LRRC47GATC HS6ST1 C6orf203 LIPT1 AGBL2 ZNF383 MACO1GBAS HSCB C6orf52 LENEP BZW1 ZNF404 SLC16A2GBE1 HSF2 C6orf57 MTO1 UMPS ZNF487 TMF1GCLM HSF5 C7orf10 STARD13 HEXIM1 ZNF526 ZNF664GDF6 HSPA14 C7orf41 SLC22A2 DCAF13 ZNF571-AS1GPAT3GEMIN5 HSPB11 C7orf49 GATC /// SRSF9ISG20L2 ZNF691 TOPBP1GEMIN6 IDI2 C8orf4 WDYHV1 WDR3 ZNF763 SNHG8GEMIN8 IER3IP1 C8orf47 SNX4 CHP1 ZNF85 TMED2GGCT IFITM2 C8orf49 GFER LOC101929760ZNF862 SNIP1GK IGFBPL1 C9 TMED7 /// TMED7-TICAM2RABIF ZSCAN12P1DPM1GK3P IGFL3 C9orf116 PRKAR1AP /// PRKAR1APBTF3P12 /// BTF3P12 WSB2GLIPR1 IGSF1 C9orf40 WNK1 RTN4IP1 CASRGLRX IGSF21 C9orf96 ADIPOR2 ANP32E ERCC5GLS2 IGSF9 CA8 CASZ1 CDV3 PIAS3GM2A IKZF5 CACFD1 RPL12 SNX12 NANSGMPPB IL10RB CACNA1A BMP10 MRPL45 AKT1S1GNGT2 IL32 CACNA1D BEX1 GEMIN6 TAF1DGNRH1 IL6R CACNB3 MEAF6 POLR2G COA7GOLGA6L9ILF3-AS1 CALCOCO2 MDH2 XRCC6 DIABLOGOLGA8CPINCA1 CALHM2 WISP2 DNAJC9-AS1 AMPHGOLGA8G INF2 CALML4 NEFM OPHN1 TLE3GP6 ING2 CAMK2G STMN2 RP13-20L14.1 MGST2GPC3 INSM1 CAMK2N1 FLJ11710 SMAP1 CCDC113GPN1 IP6K1 CAMKMT GNL3 /// SNORD19BMRPL27 RNASEH1GPR155 IPPK CAMLG RABGGTB /// SNORD45A /// SNORD45B /// SNORD45CIGF2 /// INS-IGF2 IPO4GPR37 IQSEC1 CAMSAP3 DCTN3 SOCS5 MIGA1GPR84 ISCA1 CAPN13 GATA1 CAB39 THBS1GRAMD3 ITFG1 CAPN2 SEC14L4 DPH3 ATG3GRAMD4 ITGA1 CAPN6 CD164 HRK /// LOC283454 ARFGAP1GREM1 ITGAM CAPN9 CTBP2 CISD1 PSMD5GRID1 JADE1 CAPS PLXNA1 LOC101927830 /// TMLHE-AS1GBF1GRIK1-AS2 JPH4 CAPSL ALDH4A1 PRDX6 C22orf42GRIP2 KANSL1L CARD6 RPL30 ADK FBXO33GRK6 KBTBD11 CARHSP1 CLCN3 TALDO1 NUS1GSTA4 KBTBD3 CASP1 SLC30A1 TCTEX1D1 SLC35B1GSTM2 KBTBD4 CASP10 TMEM165 MIR631 /// NEIL1 MKNK2GSTO2 KCNA5 CASP4 CRYGC PHYKPL KLHDC2GTF2E2 KCNC2 CASP5 ZIC1 ZNF585A APBB3GTF2H5 KCNG3 CASP6 CD248 TDRD6 NSUN2GTF2IRD2 KCNMB4 CASP7 CAPRIN1 COX6C RABGEF1

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GTF3A KCNT2 CASR SKIV2L2 MIR6845 /// NRBP2 ERICH5GTF3C3 KCTD14 CASZ1 MTX2 ENY2 RAB31GUF1 KCTD5 CAT RNF13 ATP2C2 SBF1HABP4 KCTD6 CATSPER1 RAPGEF3 PVRL3 ZNF827HAS2 KDELC2 CBR3 RIOK2 ANXA2 /// NHP2L1 GM2AHAS2-AS1 KIAA0895 CBX1 SEC23IP DDX21 ID4HAS3 KIAA1109 CBX2 PSMD5 LOC101926951 /// PCDH20PES1HAUS1 KIAA1257 CBX6 PAFAH1B1 GLB1L3 PPIL6HAUS4 KIAA1324 CBX8 KIFAP3 FASTKD2 MAGT1HCK KIAA1328 CC2D2A ABCE1 NRG1-IT1 LOC642366HDDC2 KIAA1456 CCAT1 IDH3A NDC1 PARP2HEATR6 KIAA1551 CCDC102B YTHDF3 EMC7 PKMHECTD1 KIF3C CCDC107 LMBR1L PPA1 REEP4HEMK1 KLHDC8A CCDC108 UNC93B1 SNRPE EIF1HEPH KLHL15 CCDC110 EXD3 LINC01004 NUP58HEXB KLHL40 CCDC125 RAB14 MYH14 FBXO8HGSNAT KLHL41 CCDC127 AGPAT5 FAM98B RINT1HHAT KLHL42 CCDC147 CTR9 NME1 SEC22B2PHIBADH KLK1 CCDC148 KCNA10 TACO1 SEC22B3PHIBCH KNDC1 CCDC151 BTK PPIL2 PLPP5HIF1A KPNA5 CCDC152 EEF1B2 /// SNORA41ATG16L2 PELOHILPDA KRBOX4 CCDC24 GLI1 HSPA4 EDA2RHIST1H2ACKRT10 CCDC28B SH3TC2 TTI1 C1QL1HIST1H2BCKRT15 CCDC41 GLO1 NOP9 PLEKHA6HIST2H2AA4KSR2 CCDC57 C12orf5 HNRNPH1 GOLGA1HIST2H2ACL1CAM CCDC68 POLE3 SSSCA1 GPN2HIST2H3A LAMP1 CCDC71L PARP2 RPP38 CFAP44HIST2H4B LAMP3 CCDC74A C16orf80 BIVM SMIM14HK2 LAMP5 CCDC81 AP5M1 AX747135 /// RP11-863K10.7PLK2HKR1 LAMTOR1 CCDC85B ARHGEF1 /// LOC100505585TCP11L1 TRERF1HLA-DQB1 LARP7 CCDC85C CYP2B6 /// CYP2B7PKCTD5 PUS1HLA-DRA LDB2 CCDC86 SLC45A2 PSMD12 DPYSL3HLA-DRB5 LDLRAD3 CCL2 TOM1L1 CDIPT NAV1HLA-J LEPREL4 CCL22 AK6 MYCN CCDC174HMCN1 LGALS3 CCL3 PNMA3 SCOC COPS3HMGB2 LGALS7B CCL3L1 DHX35 C19orf53 ISCUHMGN3 LHX6 CCL3L3 ENTPD3 POLA2 BCL2L1HNRNPC LIMS2 CCL4 RNF138 CYP39A1 ALG2HPD LINC00229 CCL4L1 ACAD8 BLVRB CARSHSD11B1 LINC00271 CCL5 ACADM LGALS3BP MIA3HSP90B1 LINC00312 CCL7 ZBTB7A LOC101929777 /// WNT3LAMA5HTR3A LINC00441 CCL8 COPS5 MRPS28 EIF1ADHUNK LINC00461 CCNA1 SERINC1 GUSBP11 CDKN1CICAM1 LINC00511 CCNB1IP1 RAB6A /// RAB6C /// WTH3DIPGAM1 COX7A2LICAM4 LINC00526 CCNI2 PRDM2 PSMD14 IMPAD1ID1 LINC00574 CCNJL SGPL1 DUSP16 PDIA4IDH1 LINC00632 CCRN4L MANF BTBD19 RNMTIDO2 LINC00643 CCT3 CLIP2 RP11-278J20.2 BOD1IER3 LINC00663 CD163 TAPT1 PAK1IP1 URB1IFNAR2 LINC00665 CD164L2 PSMD10 AK6 NEO1

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IFNGR1 LINC00683 CD180 PAX9 IARS2 LOC100419583IFT172 LINC00694 CD248 KCNJ9 KCNIP2 CDC23IFT46 LINC00870 CD274 OSBPL8 MRPL30 NSMFIFT74 LINC00877 CD2AP TRMT11 NUMBL RNF41IGFBP3 LINC00910 CD36 LGR4 TERF2 USP14IGFLR1 LINC00925 CD38 UBA5 SLC25A4 TNFRSF21IKBKAP LINC00948 CD40 PSMD8 RGS16 ZNF275IKBKE LINC00960 CD46 KCTD3 PRRT2 TBC1D23IL12RB1 LINC00963 CD47 PNOC BRWD1 TMEM19IL15RA LINC01018 CD48 C1QTNF1 ARGLU1 GFPT1IL17C LINC01071 CD6 MRPS22 SAP18 TBL2IL17D LINC01108 CD68 AMD1 COLCA1 RIOK2IL17RA LINC01116 CD7 ZNF408 MRPL42 TMEM208IL18R1 LINC01138 CD74 MAGEB2 HNRNPF ELP5IL1A LINC01139 CD80 ARPP19 PTP4A2 H2AFYIL1B LINC01155 CD82 HSPA14 THBS3 SEMA4BIL1RN LINGO2 CD83 ZNF587 MRPS18B TSR1IL23A LMO2 CD9 FUT3 INSM2 SAMD11IL24 LOH12CR2 CD99L2 JUND ZNF354C LPCAT3IL27RA LPPR4 CDC16 MLLT4-AS1CCT6P1 /// CCT6P3 IER3IP1IL36G LRG1 CDC25B ATP6V1B2 WDPCP MBD4IL36RN LRP3 CDC42BPG SLC25A32 DAD1 TMEM150CIL3RA LRRC37A CDC42EP2 AK4 /// LOC100507855AF520793 BORAIL4I1 LRRC37A2 CDC42SE2 ALOX15B PSMB2 PRKAR2BIL5RA LRRC37B CDC7 FBXO11 UTF1 PLEKHA3IL6 LRRC42 CDCA3 IMPA1 TMEM261 CHAC1IL7 LRRC4C CDH24 PTEN /// PTENP1POMP ZNF202INHBA LRRTM4 CDH5 PPP1R13L EXPH5 DYNLL2INSL3 LRTOMT CDH6 TGFB1 PDRG1 DLL4INTS3 LSP1 CDHR2 ACSF2 ARL1 GLRX5INTS6 LUZP2 CDIP1 MIR636 /// SRSF2NSUN5P1 /// NSUN5P2EMDINTS9 LY6H CDK10 DYNC1I1 NDUFS6 LINC00888IP6K2 LYPD3 CDK2AP1 CDH8 ANKRD20A11P YKT6IPO5 MAFA CDK5 FBXW12 ABCD4 UPF2IPP MAFB CDKL2 SIX1 PPP1R3D CEP68IQCC MAGED1 CDKN2AIPNLCST4 UBE3A PALM2-AKAP2IRAK2 MAGED2 CDKN2B GMFB RPAP3 SLC25A44IRAK3 MAGEF1 CDR2L GIN1 RNF115 YIPF5IRF5 MAGEH1 CDS1 TNFSF14 CREBRF MAGEH1ISCA2 MAN2B2 CEACAM1 HMG20A TMEM41A SIX2ISLR MANBAL CEACAM3 MINPP1 KIZ SEC22BITFG1 MAP1LC3CCEBPA COL2A1 NBPF10 /// NBPF11 /// NBPF12 /// NBPF14 /// NBPF15 /// NBPF20 /// NBPF8 /// NBPF9CTDP1ITGA7 MAP3K15 CEBPB REXO2 EMG1 INO80ITPRIPL2 MAP3K5 CEBPD LCK PRKAG2 MZT1ITSN2 MAP7D1 CEL CADM3-AS1AC005306.3 YARSIZUMO4 MAP7D2 CELA3A HERC2 /// HERC2P10 /// LOC101929047 /// LOC101929832PHIP LTV1JAK3 MAPK1IP1LCELSR2 STAT5A ZCRB1 BRPF3KANSL1 MAPKAPK5CEMP1 GLT8D1 FRG1 /// LOC100289097 /// LOC101930278 /// LOC101930531DERL2KAT2A MARCH8 CENPBD1 PDHX MPV17L2 TAX1BP1KCNAB1 MB21D1 CENPE CNGB1 TTC9C RSL24D1

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KCND1 MB21D2 CENPJ NOL11 CLDN7 TMEM173KCNG2 MBD4 CENPQ SOGA1 EIF3M PREBKCTD10 MBIP CENPV RAB28 GTF2E1 PSMD8KDELC1 MBOAT2 CEP41 MAN1A1 MIPEP PHKG2KDM1B MCOLN1 CEP55 AC003989.4MREG EIF3GKEAP1 MEAF6 CERK KIAA1614 PRKAB2 EXD2KHK MED27 CERS1 TSNAXIP1 TMEM185B ARPIN-AP3S2KIAA0101 MED4 CERS4 MAK16 RASGEF1A LRIF1KIAA0319L MEX3B CFB CCL7 NAA50 TBC1D10BKIAA0753 MFSD2A CFH BCLAF1 PPFIBP1 DHRS2KIAA1549L MFSD4 CFHR1 S100A1 CLEC18A /// CLEC18C PNRC1KIAA1804 MGAT4C CFLAR PVRL2 LINC01089 SLCO3A1KIFC2 MICA CFTR TRIM62 SS18L2 TFB2MKIT MIR4458HGCGREF1 LPP SLC33A1 ZNF639KITLG MKRN3 CHAD TUBB TXNDC9 BCKDHAKLF12 MMP28 CHCHD10 MED6 SHFM1 LIG1KLHL12 MNS1 CHCHD6 HYAL3 CRIP3 OSBPKMT5C MOAP1 CHD7 PTGER1 SV2B RBM8AKRT79 MOB1B CHI3L2 ZBTB1 SAFB ECE1KYNU MOGAT1 CHID1 BST2 LOC100506325 NKIRAS2L3MBTL1 MORF4L1 CHMP4B MAPRE2 TMEM183A /// TMEM183BBUD31LACTB2 MORN2 CHMP5 KCNJ13 CKS2 RASD1LAMB1 MPC1 CHN1 CBX8 SARS MRPL3LAMB3 MPC2 CHPF DDX1 NDUFA6 SEC24ALARS MPPED2 CHRM3 PSMD7 NAIF1 RBM39LBH MR1 CHRNA4 BMPR1A ACTG1P4 /// AMY2B /// RNPC3ING1LDB3 MRAP2 CHST14 CHMP1A ZNF689 SLC25A32LDLR MRPS6 CHST2 OXA1L ATF4 CNOT2LEAP2 MTERFD2 CHST8 TSN BUD31 CADM1LGALSL MTFP1 CHST9 CEP63 AIFM3 ZCCHC17LHX5 MTHFD2L CIB1 PANK3 ANKZF1 LRRC20LIAS MTPAP CIITA ADAM15 RP11-469M7.1 BMPR2LIF MTURN CINP DYNC1LI1 TWISTNB ARHGAP24LILRA5 MUC12 CIR1 GPX7 SNORA29 /// TCP1 FAM98ALIMCH1 MVB12B CISD1 FASTKD2 NGDN CHCHD7LINC00176 MXRA7 CISD3 MPC1 STX8 PRPF19LINC00339 MYBL1 CKAP4 PRKRIR KPNA1 RER1LINC00473 MYBPHL CKAP5 NDE1 SLC2A2 LAMTOR3LINC00602 MYEF2 CKB ZFR FAM166A YWHAHLINC00930 MYH4 CLC ARAP3 MSANTD2 SLC44A3LINC01106 MYLIP CLCF1 HSP90B1 /// MIR3652EXOC5 SF1LIPA MYO1D CLCN4 CLP1 ALK SIX3-AS1LIPG MYSM1 CLCN7 MYH13 TAGLN2 COPG1LMTK3 MYT1L CLDN10 UFM1 CHAC2 TM9SF2LMX1A NAA20 CLDN11 EHD2 LINC00537 RNF145LOC100289673NAAA CLDN14 LARP4 SLC35B4 MCFD2LOC730101NABP1 CLDN18 LILRA3 VTI1A SSR3LOC81691 NAF1 CLDN6 C6orf211 UFD1L DNAJB9LOH12CR2 NALCN CLDN9 ARID1A RRAGA C9orf72LRFN4 NANOS1 CLDND2 ZDHHC6 KIAA1211L DYNC1LI2

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LRPPRC NANP CLEC2D PTCD3 UQCRFS1 BBS9LRRC20 NAPB CLEC4D SIM2 TXNDC17 STAMLRRC27 NBPF24 CLIC1 CHIA RAD51-AS1 PLCH1LRRC32 NCAM1 CLIC2 GCSH /// LOC101060817LINC00184 THOC3LRRC8D NCAPD3 CLIC5 MAP7 GNG7 SORBS2LRRN1 NDFIP1 CLIP3 TCF7 CNP IFIT1LSG1 NDNL2 CLSTN1 BDKRB2 USP4 CLUHLTBP1 NDUFA5 CLSTN2 SLC12A7 DPH1 /// OVCA2 PIKFYVELTBP2 NEGR1 CLTA HNF4A MRPS16 GLULLYN NEIL2 CLUL1 MED17 MUM1 WDPCPLYRM1 NEURL1 CMBL ZSWIM1 NSA2 ATP6V0A2MACROD2 NEUROD1 CMPK2 EIF2B1 WDYHV1 DCAF1MAFF NGFR CMTM4 UBE2G1 NDUFAF1 TRIM4MAGEE1 NHEJ1 CMTM5 RDX HBS1L RAP1GAP2MAN1A1 NHLRC4 CMTM6 ABCB1 /// ABCB4EXOSC9 EFHD2MANBA NIPSNAP3BCMTM8 OGT RP11-124L9.5 UBE2MMAOA NKAP CNFN IRF5 RP11-324L17.1 FAM227AMAP2K3 NKX6-3 CNGA1 SREK1 GLB1L2 GDAP2MAP2K6 NLRP6 CNIH3 CD52 CLIC1 ARL4AMAP3K8 NOL9 CNNM3 RAB2A AGMAT COX19MARCO NOX4 CNP TMEM9B ELF2 ZNF618MAST4 NPTX2 CNPY4 CYTH3 TARBP1 CLCN6MATN2 NPTXR CNTFR PREPL ANKRD18A HIBADHMBIP NR5A2 CNTN1 ADNP TXNRD1 CYP2R1MCAM NREP CNTN3 TRANK1 FAM179A SRRDMCEE NRG1 CNTROB DAD1 STL SNX5MCM6 NRG4 COA3 SCFD1 ARID5A SYAP1MDH2 NRK COG4 CYP3A5 AK6 /// TAF9 DDA1MED18 NRL COL15A1 COG5 LOC101930075 /// LOC102724993 /// NPIPA1 /// NPIPA2 /// NPIPA3 /// NPIPA5 /// NPIPA7 /// NPIPA8 /// PKD1P1EPSTI1MEF2C NRSN1 COL8A2 RWDD1 MRPL22 ALDH6A1METTL5 NRXN1 COLEC11 PPT1 NBPF1 NDST1METTL7A NSG1 COLGALT1 EFR3B NHP2P2 /// NHP2P2 ZNF667METTL9 NTN3 COLGALT2 UFC1 MIR6834 /// PFDN6 THAP9-AS1MFGE8 NTNG2 COLQ TSPYL1 XRCC5 ARL14EPMFSD2A NUAK1 COMT CCSER2 AC005606.14 SUPT6HMGARP NUCKS1 COPG2 POLR2B LOC441124 CHDHMGC12916NUDT11 COPRS PLEKHA6 USP14 SDE2MGME1 NUDT16 COPS3 KCNJ10 VBP1 MED8MGP NUDT19 COPZ2 SUGP1 DYNLT1 SMG5MICB NUFIP1 COQ10A NRBF2 C7orf63 TIMM10BMIF4GD NWD1 COQ3 PANK4 NTN5 RTRAFMIOS NYNRIN CORO6 VAMP7 LOC101926967 SDAD1MIR146A OAT COX4I1 LECT1 MAGED4 /// MAGED4B /// SNORA11D /// SNORA11ESPATA2MIR22HG OAZ2 COX5A CD46 LMBR1L ESS2MKS1 OCIAD1 COX6A2 LAT CCDC180 /// LOC100499484-C9ORF174ABHD5MLNR OCRL CP RPLP0 MED11 UAP1MMP1 OLFML2A CPLX1 ANP32D LOC101930075 /// NPIPA1 /// NPIPA2 /// NPIPA3 /// NPIPA5 /// NPIPA7 /// NPIPA8 /// PKD1P1PITPNM2MN1 OLIG1 CPXM1 ALDH9A1 C2orf82 SLC30A4MPL OXA1L CPXM2 PIP4K2C EIF6 ISCA1MPLKIP OXGR1 CR1L OR10H3 MRPL23 GOLGB1

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MPP7 PACSIN2 CRCT1 SS18L1 AC073321.4 NOTCH3MRGPRX3 PAPPA2 CREB3L4 CMAS ESM1 XPOTMROH6 PARD6G CREBL2 CCZ1B LOC102724483 /// PIGLMAP3K6MRPL14 PARVB CRIPAK DNAAF2 SEC23IP MTA3MRPL19 PCDHA7 CRLF1 NOD1 OXNAD1 CCSAPMRPL24 PCDHB16 CRNDE MRPL17 AQP6 ARHGAP39MRPL30 PCDHB5 CROCC TXNL1 EIF3I PRPF18MRPS27 PCDHB6 CROT PCBP2 OAZ3 TMEM243MRPS9 PCDHGA9 CRTAC1 DDX5 /// MIR3064 /// MIR5047CEP72 ABCC8MSC PCDHGB2 CRTAP CABP2 CXorf21 IFIT5MSC-AS1 PCDHGC4 CRYAB MUC2 METTL3 TMEM198MST1R PCED1B CRYM MIR1236 /// NELFEPNISR HNF4AMSTN PCMTD2 CRYZ MARCH8 CCNL2 DDX18MSX2 PCYOX1L CSE1L CLCNKA /// CLCNKBDSTN COL6A1MTAP PDE4D CSF1 NEK7 SNORA72 N6AMT1MTERF2 PDE6D CSF2 ATF1 CPXM2 MRS2MTERF3 PDLIM2 CSF2RB TMEM140 MON1B BHLHE40MTFR1L PDZD2 CSF3 RPS3A /// SNORD73AATP5C1 SYNPOMTG2 PDZRN3 CSF3R SEC24B STAT4 C19orf47MTIF3 PELI3 CSMD2 CHRNE SIPA1L2 WDR43MTPAP PFDN1 CSRNP1 CCL25 TMEM91 SEPTIN8MUL1 PFKFB2 CTA-126B4.7KLHL9 VPS25 SEPHS2MUSTN1 PFKM CTAGE15 PIGP TRAPPC2 /// TRAPPC2P1GATAD2AMXRA8 PFN2 CTAGE4 MYH8 AGAP11 B4GALNT3MYO1B PGBD3 CTAGE6 MED24 IDI2 WDR19MYO1D PGRMC1 CTAGE8 DERL2 MCM9 BHMT2MYOZ1 PGS1 CTAGE9 COA1 ZNF692 DNAH5N6AMT1 PHF7 CTB-31O20.2CHGB NDUFB4 C15orf48NAAA PHLDA2 CTB-31O20.9CIC PRSS50 CNTRLNAB1 PI4K2A CTB-43E15.3SPI1 UBB CLPPNAMPT PIANP CTB-75G16.3COPS6 LOC645513 ISOC2NAPSA PIGF CTC-228N24.3CYAT1 RPL24 HDAC1NARS PIGK CTC-428G20.3RTCB NSUN5P1 RAB39BNBEAL2 PIGP CTC-462L7.1SLC35E1 MAMDC4 ANKRD11NBPF1 PIGX CTC-527H23.3SNX2 THADA SYKNBPF10 PIP5K1A CTD-2001E22.2COX7A2 COMT TP53NBPF11 PLA2G12B CTD-2008P7.9MRPL13 LLPH LOC100630923NBPF14 PLAGL2 CTD-2044J15.2HSP90AB1 LINC01341 LYSMD3NBPF15 PLEKHA6 CTD-2135D7.5CREB3L2 HIGD1A GET4NBPF3 PLEKHS1 CTD-2139B15.2KPNA3 EPHA7 INKA2NCAM1 PLN CTD-2162K18.3COPS2 MCM2 POLR1BNCF1 PLXDC2 CTD-2184D3.6HSPA2 NCOA4 SELENOWNCF1B PNLIPRP3 CTD-2195M18.1CMAHP ADAM8 MRPL2NCF1C POLD4 CTD-2339F6.1GIT1 APOOL PSMD12NCKAP5 POLR2C CTD-2554C21.2CPTP SELK PIP4P1NCOA6 POLR2K CTD-2561B21.11TMPRSS5 CH25H ZW10NCSTN POLR3F CTD-2587H24.10MAP4K3 RASEF DYMNDST1 POMZP3 CTD-2619J13.14NR3C1 C3orf62 /// MIR4271 HCCSNDUFV2 POU6F2 CTD-2619J13.17SUPT4H1 PLXNB3 RAB36NEK3 PPARGC1BCTD-3193O13.11LZTFL1 AK094644 RANBP10

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NFATC3 PPFIBP2 CTGF NBPF1 KIAA1524 SRP68NFIA PPIG CTIF ATP8B1 PCBP1 AOX1NFKB1 PPM1D CTNNBIP1 PYROXD1 TUBA4A FOXO4NFKB2 PPP1R13L CTNNBL1 COPB2 EPHA5-AS1 GPANK1NFKBIA PPP1R14C CTRC ACTL8 OGFOD1 EIF3BNFKBIZ PPP1R21 CTSC GPR124 RUSC1 EIF4HNGF PPP1R8 CTSD RBM12B-AS1PCYT1A SYS1NID1 PPY CTSF CNN1 DNAI2 TSC22D1NIPSNAP1 PRCP CTSH SERHL /// SERHL2ARPC4 /// ARPC4-TTLL3 /// TTLL3ERGNLN PRKAR2B CTSO ANP32A NUP155 SUCONMNAT1 PRKCD CTSS ARFGAP1 CHRNB1 UPRTNMT2 PRKRA CTU2 C22orf31 ENAH KIAA1211LNMUR2 PRLHR CUEDC1 BLCAP RP3-329A5.8 SORDNOA1 PRMT5 CUEDC2 CD4 SRPRB FOXK2NOCT PROC CUL2 PLEKHG3 IGH /// IGHA1 /// IGHA2AP5Z1NOD2 PROS1 CUL4B HSPA12A TOMM34 CXorf40ANOSTRIN PRTFDC1 CUTA MYO7A NUDT5 USP37NOV PRUNE CUZD1 PPBPP2 PDE4B PACRGLNPC2 PSAP CWC15 CCDC87 RAB9A SMAP1NPHP1 PSEN2 CWC27 MAN1A2 SUZ12 CCZ1BNPM3 PSIP1 CX3CL1 SMO VWCE LTN1NPTXR PSMB9 CXADR ST3GAL4 SLC18A2 SPTY2D1NQO1 PSME2 CXCL1 ZNF706 CLDN23 DNAJC10NR1H3 PTCHD3 CXCL10 UBE2A RSAD2 CDK13NRBP2 PTPLAD1 CXCL11 PCBP1 GCOM1 /// MYZAP /// POLR2MRARS2NREP PTPN1 CXCL16 RANBP2 FEN1 MDH1NRF1 PTPN18 CXCL2 PDE9A SLC24A2 NECAP1NRG1 PTPRN2 CXCL3 SPRED2 TXN MED26NRG3 PTPRS CXCL5 CDC37L1 CST7 ZNF770NRN1 PUS10 CXCL6 MOG EIF2S1 SDF2L1NSMCE1 PWRN3 CXCL9 SIPA1 CCDC51 EPB41L4A-AS1NSUN6 PYGO1 CXCR4 NDUFS3 LOC100652930 /// NPEPL1 /// STX16-NPEPL1DNAAF5NTAN1 PYURF CXCR5 INCENP ZMYND11 SLC35F6NTM QDPR CXorf36 CDA ANKRD33 UBE2J1NTN5 QPCT CXorf49 GPR21 DDX5 /// MIR3064 /// MIR5047PDE9ANUDT16P1 RAB12 CXorf49B HNRNPH2 /// RPL36A-HNRNPH2RET TYW3NUDT5 RAB1A CYB561D2 CDK4 NUP88 SULF2NXN RAB3C CYB5A EIF4E LRRC23 /// RPL13P5 COA8OARD1 RAB3D CYB5RL EGOT ZMAT2 TRMT61AODC1 RAB7L1 CYBRD1 ARPC5 MUC19 MLECODF3B RABL5 CYHR1 RPL23A /// SNORD42APABPN1 BRPF1OGFRL1 RAC3 CYLD HIST1H3E LINC00260 ABI3OGT RAD54L CYP21A2 API5 THOC1 NELFEOLA1 RAE1 CYP24A1 WAC ABCA6 PPAN-P2RY11OLFM4 RALGPS1 CYP26B1 EIF1B ECHDC2 EXOSC1OPA3 RAP1GAP2 CYP2U1 LOC729966 /// PDE4CID4 AP1M1OPCML RASGEF1B CYP39A1 PAPSS1 TRIM52 ARPINOR2A1 RASGRF1 CYP3A4 PLEKHF2 LOC101929465 APBA3OR51E2 RASSF5 CYP3A5 UBE2Q1 IQSEC3 PRSS23OSBP RAVER2 CYR61 SEC13 EXOC7 DDX46

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OSBPL1A RBM48 CYS1 CAND1 MRPL35 REXO4OSGEP RBP4 CYSLTR2 ZCWPW1 RPL7AP71 /// RPL7AP71PRICKLE2OSGEPL1 RCAN3 CYTH3 MRPL49 CRIPAK DNAJC9OSM RECK DACT2 ATP11A PRICKLE2 ZNF547P2RY13 RET DACT3 CROCCP3 OSTM1 GCKPABPC1L RFPL1 DALRD3 NCBP2 CNST DERL3PADI2 RFXAP DANCR SLC25A3 ABHD5 UTP25PAK7 RGPD3 DAND5 CRH ZFR2 RRN3PALB2 RGPD4 DAO SOX2 SHQ1 HDLBPPANK1 RGPD8 DAPP1 SLC30A9 CMIP /// LOC100129617GLT8D2PAPD5 RGS2 DARS2 HLTF ORMDL2 BAHCC1PAPPA RGS9 DBH KCNQ1DN DSCR3 SPATA17PAPSS1 RHBDD2 DBN1 HIRA SLBP CERS2PATZ1 RHBDL3 DBNDD1 UCHL5 ZNF831 PRKAB2PAXIP1-AS1RHOBTB3 DBP ZNF696 ASXL1 CRELD2PCBD1 RHOQ DCAKD CITED2 LCMT2 CHERPPCDH15 RIMBP2 DCBLD2 PTDSS1 ACCS ERLEC1PCDH18 RIPK1 DCLK1 PVALB IPO11 /// IPO11-LRRC70LLGL1PCGF6 RMDN2 DCLK3 SH3BP2 CHTF8 BLCAPPCMTD1 RNF152 DCLRE1C TDP2 RWDD2B PTPRJPCYOX1L RNF181 DCTN2 KRT33B METTL2A /// METTL2BLIN52PDCD4 RNF4 DDAH1 ELL2P3 /// ELL2P3TAF1A-AS1 MIEF1PDCL ROPN1 DDB2 MAFB RP3-406P24.1 SPTBN2PDCL3P4 RORB DDC SPC24 LOC100507520 TVP23C-CDRT4PDE4B RP11-1000B6.3DDHD1 SRP9 STAU2 DHX57PDE9A RP11-1000B6.5DDN NTSR2 NXT2 F2RL3PDGFRL RP11-100G15.10DDO PVRIG ECD HS6ST1PDZD11 RP11-101E14.2DDR1 APOC1 RUVBL1 TOMM40PEBP1 RP11-1094M14.11DDX27 PAWR KCNH8 MCPH1PELI1 RP11-109D9.4DDX42 ANKRD49 LOC101060179 /// PRDM11MSTO2PPEX1 RP11-111K18.2DDX58 PML UBE2L3 FUT8PF4V1 RP11-1151B14.2DDX60 EIF4H AX747132 /// RP11-458D21.1 /// RP4-791M13.3ABCB8PFDN1 RP11-122K13.14DEAF1 RFX5 MYL4 RBM47PGAM4 RP11-129M6.1DEFB4A CCDC9 LOC101928669 /// LOC101930100 /// LOC644450LOC652276PGAP3 RP11-131K5.1DEFB4B TCEB3 TTC7B FAF2PGK1 RP11-158H5.7DENND2C GDI2 MAPKAP1 MAPK8PGLYRP2 RP11-180P8.3DENND5A ELOVL5 MAP3K4 WRNPGM2 RP11-182L21.6DES KIAA1654 CHMP3 /// RNF103 /// RNF103-CHMP3PRELID1PHF8 RP11-209K10.2DESI1 KRT8P11 /// KRT8P11DAP3 CYGBPHLDB1 RP11-222K16.2DFNB31 IGKC /// IGKV1-5 /// IGKV1-5 /// IGL@SQSTM1 ARV1PHYH RP11-22L13.1DGCR6L GPATCH2 COA1 EPRSPID1 RP11-247L20.4DGKG CCR5 DLAT MYRIPPIM2 RP11-268G13.1DHRS11 ACAT1 WSB2 MIS12PITPNA-AS1RP11-271M24.2DHRS4 CTF1 ACAT2 ODR4PITPNC1 RP11-290F20.3DHRS4-AS1ALG9 GUSBP2 RAB3BPITPNM3 RP11-293M10.5DHRS4L2 BTBD3 HEXDC MESTPKM RP11-2B6.3DHRSX PEG10 C5orf66 TTLL11PLA2G12ARP11-2E17.1DHX58 OCM2 TRIP4 TPRG1LPLAT RP11-30K9.6DIAPH1 TRADD CAP1 TMEM64PLAUR RP11-317P15.5DIRC1 LOC339166 /// WSCD1LTB4R RMDN3

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PLCG1 RP11-31F15.2DLEU1 MC1R SCYL2 NR4A3PLD2 RP11-326C3.13DLL4 RPS3 LL22NC03-N14H11.1 COG5PLD6 RP11-345J4.5DMGDH TOR1AIP1 IKBKAP NCAPH2PLEK2 RP11-347C12.10DMPK CD177 FGR PLXND1PLEKHM3 RP11-375B1.3DMRTA2 HSPB6 CNTRL HCFC1PLPP3 RP11-381O7.3DMTN LANCL1 STEAP3 HIC1PLSCR1 RP11-38P22.2DNAI1 LRP1 DMTF1 EIF5PML RP11-419C23.1DNAI2 ORC3 RSL1D1 C1orf52POFUT1 RP11-423O2.5DNAJA1 DLK1 GSTZ1 CXXC1POLA2 RP11-42O15.3DNAJC22 KCNH4 CSAD OSER1POLH RP11-433J8.1DNAJC4 SGMS1 OLIG1 NVLPOLR1B RP11-466C23.4DNAJC5 C6orf48 PLA1A ZC3HAV1POLR1D RP11-472N13.2DNAL4 PCNXL2 DHDDS NLE1POLR3GL RP11-480D4.6DNPEP KRT20 EIF3H AGO3POMGNT2RP11-480I12.7DNPH1 RAD21 LAMTOR5 PPATPOMT1 RP11-48G14.2DOK4 ALG11 /// UTP14CKCNH3 MRPL49POU2F2 RP11-496B10.3DPF1 MRPL39 RP11-710C12.1 KDRPPFIBP2 RP11-498E2.7DPH5 IDH3B LOC101060604 /// SLC7A5P1 /// SLC7A5P2ZNF529PPIP5K2 RP11-502I4.3DPP7 LOC101928625 /// MED21LUC7L CENPBD1P1PPM1H RP11-51J9.5DPY19L2 PRRC2A MTMR6 GPATCH1PPP1R12B RP11-521O16.2DPY30 AGRN ARMC10 GIPC1PPP1R32 RP11-532F6.4DPYD TOB1 BAI3 CCDC59PPP2R1B RP11-533E19.5DPYS CXCR3 CCNY YIPF2PPP2R2D RP11-543C4.1DRAM1 DUX1 /// DUX3 /// DUX5HMOX2 SPSB3PPP2R5C RP11-557C18.4DRAXIN MEST mir-223 ALDOCPRELP RP11-563J2.2DROSHA FNBP4 ADAM23 EBNA1BP2PRIM1 RP11-572M11.3DSC2 C12orf29 CUBN ARL4CPRKAA2 RP11-573G6.10DSCAM SYDE1 OFD1 PCDH7PRKAB2 RP11-61J19.4DSCC1 MIER2 TM2D2 XYLT2PRKAG1 RP11-622K12.1DSE PSMC2 LOC100506538 C11orf95PRKCH RP11-626H12.2DSPP G3BP1 RP11-1007O24.2 NDUFS1PRMT3 RP11-626K17.3DSTN POLR1B CNIH4 ACVRL1PROS1 RP11-637A17.2DSTYK TSPAN7 LOC100506314 DBNDD1PRSS35 RP11-646I6.5DTD1 MRPS30 ZNF622 CRLS1PRSS50 RP11-689K5.3DTD2 EDC4 RAP1B COG3PSD3 RP11-6N17.4DTL PADI3 ALDOA TMEM26PSMA5 RP11-77P16.4DTWD1 CPLX3 AC128677.4 /// CH17-132F21.1 /// IGKV1OR-1 /// IGKV1OR-1 /// IGKV1OR10-1 /// IGKV1OR10-1 /// IGKV1OR2-2ATG2APSMA7 RP11-79O8.1DTX2 LSM14A SCD TEX261PSMC4 RP11-79P5.9DTX3L RNF130 TMEM132A PAFAH1B3PSME3 RP11-7F18.2DTYMK FAM208A ARPC3 PRMT5PSMG1 RP11-7K24.3DUOX1 JOSD1 KCNK1 GNG2PSTPIP2 RP11-822E23.8DUOX2 NIF3L1 SNRPC KLHDC8APTAFR RP11-831A10.1DUOXA2 GZMM NDUFA7 TM7SF3PTGES RP11-855O10.2DUS1L ATP5G3 C2orf47 ZNF542PPTGS2 RP11-85G18.6DUSP1 SET /// SETSIPMYO5B THUMPD1PTK2B RP11-91G21.1DUSP10 STAG1 MRPS10 UBA6-AS1PTPN18 RP11-91J19.4DUSP14 CKAP2 /// IGLC1 /// IGLV1-40 /// IGLV1-40 /// IGLV1-50 /// IGLV1-50PAFAH1B2 ORC3PTPN6 RP11-923I11.6DUSP2 URI1 IFIT5 KLF15PTPRO RP11-92K15.3DUSP26 NUDT9 IGJ RXRAPXDN RP11-97O12.2DUSP6 TMEM212 RP5-1092A3.4 ABCF1

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R3HDM4 RP13-539J13.1DYNLT1 SLC8A1 LARP4 CTU2RAB11FIP2RP13-631K18.3DYSF ACAP2 KCNQ2 PRPF6RAB20 RP3-393E18.2EBI3 RUNX3 ATP5G1 EVI5RAB24 RP3-400B16.1EBPL GLB1 /// TMPPEPRF1 PARP9RABGGTB RP3-430N8.11ECH1 PMF1 ARMC12 MGAT1RABL2A RP4-535B20.4ECHDC2 NPVF NISCH PMS1RABL2B RP4-594I10.3EDC4 FYB POLM LMLNRAC2 RP4-666F24.3EDEM2 GPD2 SYT1 PLAG1RALGAPB RP4-765H13.1EDN2 C2orf47 KCTD16 ZNF570RALGPS1 RP5-1004I9.1EDN3 NPEPL1 DDB2 ZSCAN2RAMP2 RP5-1021I20.2EEF1B2 LOC729164WASL RABL2BRAP1GDS1RP5-933K21.3EEF1G PSMB3 NOP10 PTMSRAPGEF3 RP6-206I17.3EFCAB3 PPP1R2P9 NET1 NREPRARRES1 RPAIN EFCAB4A PLP2 ARID4B /// RBM34 GTPBP2RASD1 RPH3AL EFCC1 PRKCH CIB1 MRPL55RBAK RPL10A EFHC2 CLUHP3 LINC01346 PITPNC1RBM12B RPL11 EFHD1 SSR3 LOC440434 RAB6ARBM33 RPL12 EFNA4 FAM13B MTDH PRELID3BRCE1 RPL13 EGFL8 NGB C1orf168 SAMD1RDH10 RPL18A EHD1 DDR1-AS1 CHRNA1 OXCT1RELB RPL23A EHD4 KLF11 CYS1 GAR1RELT RPL32 EHHADH SLC2A14 /// SLC2A3PTCHD4 PITPNM1RGS5 RPL35 EID3 IRF4 AK096592 /// YLPM1 NUDT21RHBDF2 RPL35A EIF2A NR4A3 PDE7B CTSORHCG RPL36 EIF2B3 EFS RNF113A DCUN1D2RHOA RPL37A EIF3A LRBA TTL NKX2-2RHOQ RPL4 EIF3E GSTA4 FKBPL ACO2RIMBP3B RPL7 EIF3F MASP1 AK057657 /// RP11-473I1.9FAN1RINL RPS12 EIF3J-AS1 NUP93 CROCC TMEM37RIPK2 RPS19 EIF3K KIF5C TMEM11 ANKS3RIT1 RPS2 EIF3L NRGN RP11-399E6.1 IBA57RNASEH2B RPS24 EIF4EBP2 ANGPT1 ZNF697 TMEM184ARNF149 RPS29 EIF5A IFNB1 MEFV REXO2RNF168 RPS5 ELF3 SLC16A8 ABHD3 PITPNARNF170 RRAGB ELF4 SCML1 PIANP ZNF473RNF19B RRAGD ELK1 CKS1B RNF181 RTL6RNF24 RRN3 ELL ID4 BMP2 DRG1RNFT1 RSPH10B ELOVL7 IDE TCP11L2 ATAD3BRNPEP RTN2 ELP4 HOXC8 SIDT2 SASS6RORC RTP4 EMCN GTF2H3 LOC101928464 LRRC32RP9 RUNDC3B EMID1 C1QBP ADH1B TAF5RP9P RUNX2 EML6 AK6 /// TAF9MAFG MARVELD3RPL17 S100A14 ENDOG CST3 ZSCAN31 LDLRAD4RPL23AP53SAAL1 ENHO PREB APTR TBC1D10ARPL34 SALL2 ENKUR SPATA5L1 PSMA4 GON4LRPL5 SAMD3 ENOPH1 MTR CTNNA1 MTPAPRPP30 SAMD9L ENPP7 SC5D AHSA2 FUCA2RPP40 SAMM50 ENTHD1 ALDH1L1 MTIF3 KLC4RPS3A SBK2 ENTPD2 TMPRSS3 GPATCH11 ZNF3RPS7 SCAMP5 ENTPD3 KIAA1279 R3HDM1 MKRN2

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RPSAP58 SCARB2 EPB41L4B MAZ APMAP MIB2RTCA SCG3 EPHA1 MUC3A /// MUC3BAQP5 PSMD3RUNDC3B SCGB2B2 EPHA2 ANKMY2 TRIAP1 GRASPRUNX1 SCGB3A1 EPHA4 STAM CCNC GPR4RUNX3 SCGN EPHB2 POLQ EIF5A2 TXNL4BRWDD4 SCIN EPHB6 AIFM1 JMJD7-PLA2G4B /// PLA2G4BNAA15S100A9 SCP2 EPHX2 TNFRSF1B TIA1 COPS2S1PR1 SCPEP1 EPHX4 MTUS2 MRPL51 TMEM167BSAA1 SDE2 EPSTI1 ZBED5 HBB TSPAN13SAA2 SDPR ERAL1 PPFIA2 CACNA2D3 ZFAND1SAA3P SEC14L5 ERAP1 PCNA ABCE1 PCYT1ASAA4 SEMA3G ERAP2 NBEAL1 /// RPL12VTA1 DSN1SAC3D1 SEPT1 ERCC2 COPS7A RALY CYP27A1SAMD13 SEPT11 ERCC5 DDX51 TPRKB VSTM2LSARM1 SEPT3 ERI1 CCR3 COIL TRAPPC10SATB2 SEPT6 ERICH2 SMNDC1 USP46 TSPAN9SBNO2 SEPT8 ERLIN1 STARD5 STX16 ARSDSCARF2 SERF1A ERO1L COIL MRPL48 NKAPSCD5 SERF1B ERP27 KCNAB3 GLRA1 GOLPH3SCFD2 SERP1 ERP44 KPNA6 TTC21A ELP1SCGB1D2 SERPINI1 ERVMER34-1LBP SETD4 GOLT1BSCO1 SERPINI2 ERVV-1 CALM1 /// CALM2 /// CALM3DEF8 TMEM132DSCRT1 SESN1 ESM1 CNOT8 TRO BUB3SEC24A SETD2 ESYT1 PSMD14 AAR2 PRKAB1SELK SGCE ESYT3 CARD14 MST1R MPV17LSEMA4B SH3BGRL ETFDH MAPK8IP3IGKV1-17 /// IGKV1-17EIF3FSEMA4F SH3GL2 ETNK2 KRT2 AX747630 MTHFD1LSEMA6C SH3KBP1 ETS2 ENDOD1 GLRX2 SMAD9SEMG1 SIGLEC10 ETV4 TSR1 NDUFA9 SEMA3FSEPP1 SIMC1 ETV6 UBA2 ANP32A NUBP2SERAC1 SIX5 ETV7 ARPIN GLTSCR1L AKTIPSERPINB7 SLBP EVPL KIZ RP3-476K8.3 NIPA2SERTAD1 SLC13A5 EXOC3L1 ZNF287 ATP5S SNHG16SETD3 SLC16A9 EXOC3L4 GABRR2 AOC2 EEF1AKMT4SFR1 SLC18A3 EXOC6 FLJ42627 PDE12 MIR22HGSFRP5 SLC1A5 EXOSC5 WT1-AS BC048103 /// CSGALNACT1FLT1SFXN3 SLC22A15 EXTL2 MYH3 SNRPA1 WNK2SGCZ SLC22A16 EZH1 LINC00563 SSB LINC02593SGK2 SLC25A36 F11R CNPY4 SMIM15 DDX51SGMS1 SLC25A38 F13A1 MEGF6 AGAP10 /// AGAP11 /// AGAP4 /// AGAP5 /// AGAP9 /// BMS1P5 /// CTGLF12P /// LOC101060581CDC37L1SGPP2 SLC25A47 F2RL1 SLC24A2 STKLD1 GPX2SH3BGR SLC25A53 F7 SEPT10 KSR1 NOP58SH3PXD2B SLC29A1 F8 C8orf33 FAM98A KRBOX4SHC1 SLC30A4 FADS6 WFDC1 TENM2 ZMYM3SHISA5 SLC30A8 FAHD2B ETAA1 MFSD8 C12orf29SIAE SLC35E4 FAM101B PDHB RPF2 LINC00365SIDT2 SLC38A4 FAM102A WDR47 LOC100996724 JUNSIGLEC14 SLC38A5 FAM105A ADAM19 CPNE3 KLHL5SIL1 SLC43A2 FAM109A TMED3 GPR143 MYT1LSIRT3 SLC44A5 FAM110C CCNB1IP1 EXTL3-AS1 FBXO4

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SIRT5 SLC46A3 FAM114A2LAIR2 PSMC6 TRMT2ASKAP2 SLC4A8 FAM115C LAMTOR3 CTD-2012K14.6 PDE12SLAMF1 SLC5A12 FAM117A RAB11FIP2 ILF2 DLG2SLC11A2 SLC9A9 FAM117B CACNB3 SPRYD7 MSRB2SLC16A2 SLCO1A2 FAM122C BRF1 PODN DOCK6SLC16A3 SLITRK1 FAM124A RP11-10N23.4MTFP1 GOLPH3LSLC17A4 SMARCA1 FAM124B CCPG1 /// DYX1C1-CCPG1FBXL5 DIS3SLC17A5 SMARCC2 FAM133B PAM STK36 ZNF417SLC1A3 SMIM4 FAM135B TOX3 MC1R UBA6SLC20A1 SMIM6 FAM136A ANKRD10-IT1KIF5B FEM1CSLC22A4 SMN1 FAM159B RUSC2 SET /// SETSIP SOCS7SLC22A5 SMOC1 FAM171A1IGLV4-60 /// IGLV4-60TLL2 ZPR1SLC23A3 SNAP91 FAM171A2OSBPL10 SC5D EEPD1SLC25A15 SNIP1 FAM173B TERT REL EPB41SLC25A21-AS1SNRNP27 FAM174B LRRC20 C4orf46 TMEM67SLC25A27 SNRNP48 FAM177A1PDCL3 /// PDCL3P4AL022344.5 PAICSSLC25A36 SNX12 FAM179A DOC2A USH2A UTP11SLC25A43 SNX29 FAM184B MAMLD1 POLR2D IDH3ASLC25A51 SOCS2 FAM186B TMEM59 NTMT1 TIAM1SLC27A1 SORBS1 FAM188B EEF1E1 EARS2 HGSSLC27A4 SOX9 FAM189B RNF139 TXNIP SS18L1SLC29A2 SPAG16 FAM195A HERPUD1 IGFN1 CA4SLC2A4RG SPAG5 FAM195B HLA-DMB CGA IFT80SLC2A6 SPARC FAM198B MAGI1 PARP6 MEX3CSLC2A8 SPATA18 FAM19A4 KCTD17 EVL PDGFASLC31A2 SPATA7 FAM200B RIOK3 PDCD2L PAQR8SLC34A3 SPATS2 FAM203A CANX YRDC VARSSLC38A3 SPCS1 FAM211A CRTAC1 TTLL10 RNF126SLC39A10 SPOCK2 FAM211B DPP8 FAM214B B3GNT8SLC39A14 SRGAP3 FAM213A TMED5 OTUD6B-AS1 FLOT2SLC3A1 SSTR2 FAM219B PSMG2 BEND3 RANBP1SLC40A1 STAR FAM228B LOC101928378NDUFC1 LCMT1SLC43A2 STMN2 FAM26F SLC25A17 TMEM150A GTF2F2SLC46A1 STOM FAM46B RGS12 MRPS17 RAB15SLC46A2 STON2 FAM50B RPL11 MMGT1 FEN1SLC4A11 SUMO3 FAM53A LY6D BTNL9 PTK7SLC6A14 SVIL FAM63A GOLGA2P5ARHGEF37 ZNF674-AS1SLC7A11 SVIP FAM76A CHKB-CPT1B /// CPT1BPOLR1E WDR36SLC7A5 SYNDIG1L FAM78A GOLIM4 FAM175B GRIA4SLC7A5P2 SYT11 FAM78B GPLD1 USP22 SLC2A12SLC7A9 SYT15 FAM81A SLC26A2 ID3 YIPF4SLCO4A1 SYT6 FAM90A1 RAP1GDS1UBE2K LRRC1SLCO4A1-AS1SYT7 FAM92A1 CYP4F12 ADAM33 EFL1SLMAP SZRD1 FAM98B C14orf1 CCNB1IP1 BOD1L1SMAD7 TADA1 FAM98C C21orf2 KCNB1 SNCBSMARCA1 TAF5L FAS PPP2R5C PPM1M HHEXSMC3 TAGLN2 FAT1 NRCAM TP53RK CYB561D2SMIM19 TAPT1 FAXC SKAP1 TPI1 GNA11SMIM3 TATDN3 FBP1 ANXA13 BC024027 /// RP11-268G12.1PTRH2SMIM8 TBC1D20 FBXL16 POGK UBE3C MMRN2

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SMOC2 TBCC FBXL4 FAM8A1 WDR53 ARHGAP5-AS1SMYD3 TBPL1 FBXO24 DCSTAMP ANXA2P3 DPH3SMYD5 TBX1 FBXO25 RHOBTB3 ETF1 EMSYSNAPC2 TCEA1 FBXO6 TRAM1 SMAD3 TMUB2SNAPC5 TCEAL1 FBXO7 MYL1 KIAA0087 IRF2BPLSNCAIP TCEAL4 FBXW9 FAM96B RP11-332H18.4 TRMT112SNHG1 TCEAL7 FCAMR CHRNA2 OSGIN1 RIOK1SNHG8 TCEAL8 FCER2 ADARB1 TMEM223 MORF4L2SNORD76 TCEANC FCGR1A SEC61A1 C12orf43 PRR15LSNPH TCEB1 FCN3 MRPL19 NAA40 TXNDC12SNUPN TCERG1L FCRL4 DNAI1 MRPL54 PIP4K2BSNX17 TCF24 FCRLA VPS26A UBE2QL1 TMEM14ASNX5 TCTEX1D2 FEM1C SHC1P1 /// SHC1P1NDUFA4 KMT5CSOAT2 TEC FERMT1 TMEM126BKLHL31 TRUB2SOCS1 TGFBRAP1 FEZ1 MFAP3 RPL14 GOLIM4SOCS3 THBS1 FFAR2 NR2F1 /// NR2F2OXSR1 LAMP3SOD2 THG1L FGB ADAM29 /// LOC101928551FANCL SNHG20SORBS3 THOC5 FGD1 VPS4B MBD6 HIP1RSOX13 TIGD6 FGF1 PAXBP1 ANXA2P1 GAD2SOX8 TIGD7 FGF10 IFT52 LOC101928521 PLEKHG2SP6 TIMP2 FGF14-IT1 APOBEC3C RP11-533E19.7 HSPA14SPAG8 TINAGL1 FGFBP3 MAP1LC3BCHCHD2 ZNF347SPARC TINCR FGFR3 POLDIP3 /// RRP7BSFPQ CLEC1ASPATA32 TIPIN FGFR4 PAX2 MFI2-AS1 MIR210HGSPEF2 TM6SF1 FHDC1 LAMA4 KBTBD8 CADPS2SPIN2A TMC6 FHL1 ERC2-IT1 PLRG1 TSSC4SPIN2B TMEM100 FHL2 GCC2 QRICH2 MXRA7SPOCD1 TMEM109 FHOD1 TPD52 IGLV1-44 CALRSPOCK1 TMEM128 FHOD3 RPS15A ANKRD36B TAGLN3SPRR1B TMEM130 FIBIN KHDRBS2 ITGAL LRIG3SPRY4 TMEM170BFIGF SEPT5-GP1BBDANCR INPP5ESQRDL TMEM184BFILIP1L PPP6R1 PFDN1 KDM7A-DTSRA1 TMEM185AFJX1 LRRC61 RBM8A YME1L1SRD5A1P1 TMEM189 FKBP1B TPRKB DLG5 PRKCDSRGAP3 TMEM208 FLNA IGKV1-37 /// IGKV1-37 /// IGKV1D-37 /// IGKV1D-37RPS6KA2 DDIT3SRSF6 TMEM230 FLNC DHX34 LOC101927560 /// LOC101927587SUPT5HSRSF8 TMEM231 FLRT2 RALGAPA1FARP2 SLC33A1SS18L1 TMEM232 FLVCR1 KIAA1751 MIR3658 /// UCK2 COPB1ST3GAL1 TMEM242 FLYWCH2 GFPT1 VAT1 RNPS1ST3GAL4 TMEM251 FMN2 CXCR5 ZNF813 CEP57ST5 TMEM255AFMNL2 FHL3 GNL2 CDKN2AIPST8SIA2 TMEM52 FMO5 SMG8 ANXA10 LAMB1STAT3 TMEM55A FN3K CRX TPCN1 CXCR4STC1 TMEM59 FNDC4 ETFA NPIPA1 WASF1STC2 TMEM66 FNDC5 ERICH1 FYTTD1 MINDY2STEAP1B TMEM92 FOSL2 TAS2R16 RMST RBM27STIM1 TMEM9B FOXA2 SEMA3F INSIG2 ERVK3-1STMN1 TMX4 FOXP4 CCT7 STRADB PTPRHSTOML1 TNFSF4 FOXRED2 CRNN TNFRSF12A KAZNSTOX2 TNNC1 FOXS1 ORMDL2 ARHGEF25 CMC2

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STRADA TOP2B FPGT PSCA CRLF1 GPR180STRBP TOX3 FRAT1 ITGA9 CSRP2BP /// PET117 ZFP3STX11 TP53 FRAT2 EIF2S2 CCDC85A SLC18B1STX3 TP53INP2 FRMD3 VDAC2 RNF34 LAMA1SUDS3 TPH2 FRMD4A HSF2BP CCDC39 /// LOC101928882OSGEPL1SUGCT TPPP3 FRMD6 ASAP3 CTB-43E15.1 MAOBSUMO1P1 TPR FRMD8 GAK LINC01410 VPS33ASUPT6H TPRG1L FRRS1 PRMT5 DCTN6 SLC26A2SVEP1 TPST1 FRS3 OSBPL9 LOC339539 DUSP11SYNDIG1 TRAK1 FRYL CRHR2 GALNT14 POLD3SYNJ2 TRAM1L1 FRZB TSKU CMPK2 TCF7L2SYNM TRAM2-AS1FSCN1 ENTPD2 LRRC6 CABLES1TACR1 TRAPPC10 FST NPY6R RP4-539M6.21 BET1TAF11 TRIB2 FSTL3 FCF1 /// MAPK1IP1LRGL3 NABP2TAF1D TRIM71 FTH1 PGLYRP1 ARFIP1 NHP2TAF5L TRIQK FUNDC1 CRIP1 SLC30A1 DNAJC5TAGLN TRMT61B FUT1 BTNL8 NANOS3 KLF7TAMM41 TSGA10 FUT5 GABARAPL3AGPS OTUD5TANGO2 TSHR FUZ GPR63 ASH2L PRELPTAPBP TSPAN2 FXN YBX1 RIPK4 COPB2TBC1D4 TSPYL1 FXR2 SSX3 COX10 CDKAL1TBX3 TSPYL6 FXYD6 STAG3L3 CNTNAP5 MRC2TCAF2 TTC19 FYB BCAS2 MRTO4 CCNT1TCEA2 TTC21B FZD2 VBP1 CEBPG PAGR1TCEAL4 TTC23 FZD5 BTAF1 ASPH ATP8B2TCEAL8 TTC34 FZD9 LOC101930324 /// NSFDAPK3 DYRK4TCHP TTC39C G0S2 IL25 CCDC144A /// CCDC144B /// CCDC144CP /// LOC101929141KAT8TCOF1 TTC7B G6PC2 ALKBH1 COPS3 SELENOITCP11L1 TTLL9 GABARAPL1TARP TES MLH1TDRD3 TUBB1 GABRD LOC101929304 /// SNX29SCNN1B ZNF283TESC TUBB8 GABRG2 RAB5A CCDC24 LEMD2TEX2 TUSC3 GALK1 SMPDL3A FGFR1OP SETD7TFAP4 U2SURP GALM LOC101060521 /// POLR3EPRDX5 HSPB6TFE3 UBAC2-AS1GALNT11 COL9A1 KIF2A SLC30A6TFPI2 UBE2E2 GALNT16 OR11A1 GSTM3 C16orf46TGM2 UBE2G1 GAMT TARS GNA13 TMEM229BTHAP12 UBE2Q2 GAS6 GPR153 PABPC1L AHDC1THBS1 UBTD1 GATA6 CRLF3 SLC24A3 NEGR1THNSL1 UBXN10 GATA6-AS1GNAI1 ZNF337 TIAL1THRA UNC13D GATM SLC25A36 METTL8 CREB3L1THUMPD1USP27X-AS1GATS LMAN1L HSPE1-MOB4 /// MOB4C16orf91THUMPD3-AS1USP39 GATSL3 IL36A ARHGAP33 TBC1D25THYN1 USP49 GBP1 HRASLS2 PRSS23 KIAA1549TIAL1 USP54 GBP2 GPA33 PMFBP1 DNAJC2TIMM10B VAMP4 GBP3 TLK1 UBTD1 CFAP36TIMP2 VMA21 GBP4 LPXN MUC12 ZER1TLL2 VOPP1 GBP5 NUP153 IGLL3P PSMG3TM4SF18 VSIG4 GBP6 DDX21 NACA TMEM167ATM7SF3 VWA8 GBP7 MRPL18 SFI1 ZNF362TMED1 WBP11 GCHFR FRS3 DRAP1 HSPA13

Page 59 of 781 Diabetes

TMEM106CWBP5 GCNT3 ARHGAP15 /// LOC101928361CYB5R4 CCP110TMEM132AWDFY2 GCSH SLC6A20 ZNF57 LDB1TMEM133 WDR20 GDF11 TXNL4A DKK1 MTO1TMEM143 WDR37 GDF5OS KCNB2 ABT1 PIH1D1TMEM145 WRB GDF6 ALDH1A1 MCAM /// MIR6756 BRSK1TMEM14A WWOX GDI2 ARID5A AKIRIN1 STAT6TMEM150AXPA GDPD1 GCA ANKRD36 MR1TMEM150CXXbac-BPG55C20.7GDPGP1 CSTF3 PITPNM2 FHOD3TMEM165 YRDC GFPT2 IGLC1 SNED1 CBX6TMEM169 YTHDF1 GGCT ITFG1 PSMA2 SART3TMEM192 ZADH2 GGNBP2 SNCAIP PDE1A WDR46TMEM223 ZBTB1 GGT1 MAP2K7 DLEU7-AS1 MNX1TMEM230 ZBTB2 GGT2 STRAP ABCC5 FNBP4TMEM234 ZBTB26 GGT6 FZD2 LARP7 NFX1TMEM25 ZC3H12B GGTLC1 AP3B1 SKP2 MMUTTMEM253 ZC3H14 GGTLC2 CD38 UBE2V2P3 /// UBE2V2P3NUP214TMEM260 ZC3H7A GID4 TAOK1 CCNK ZCCHC4TMEM39B ZC4H2 GIMAP2 SERPINB10MICU1 CDC5LTMEM41B ZCCHC18 GIMAP7 RNF6 STK35 TRAPPC2BTMEM42 ZCCHC6 GINS2 NOC3L IGLC1 ZNF470TMEM43 ZDHHC24 GIT1 KIF2A MIR3934 /// UQCC2 DDX19ATMEM72 ZER1 GJA4 UBE3B CALY RNF185TMEM74 ZFP37 GJB1 MKL1 VRK2 CNEP1R1TMEM88 ZIK1 GJB2 SERPINF2 HMHA1 UBE4ATMEM92 ZKSCAN2 GJB5 PLEKHB2 MRPS11 TRAK2TMEM98 ZMIZ1 GJD2 NDEL1 LOC101928524 /// PRPF18ERG28TMPRSS5 ZMYM5 GK CAPN5 PREP RAMACTMX1 ZNF12 GKAP1 ITGAE DFFB DDR1TNF ZNF134 GLI1 RPF1 TBC1D7 MCMBPTNFAIP2 ZNF136 GLMN CCL16 AZIN1 CCDC186TNFAIP3 ZNF14 GLO1 IGHG1 /// LOC100293211YTHDC1 SLC4A1APTNFAIP6 ZNF140 GLOD5 GPN3 TMEM189 /// TMEM189-UBE2V1 /// UBE2V1 /// UBE2V2IARSTNFAIP8 ZNF157 GLRA1 DPYSL4 ZNF829 HBP1TNFSF13B ZNF17 GLRB MFAP1 EML6 RCN1TNIP1 ZNF175 GLRX SCAMP1 RBM47 EIF4EBP1TNIP2 ZNF180 GLRX5 GOLGA4 TMA16 ADM2TNIP3 ZNF222 GLS2 MYCLP1 /// MYCLP1CDK9 TIGD7TNXA ZNF223 GLT8D1 IGK /// IGKCLOC100128922 NBEAL2TOLLIP-AS1ZNF230 GLT8D2 PRKACB TKT RLIMTOM1L1 ZNF26 GM2A ADAM28 MARVELD2 GLIPR2TOMM34 ZNF263 GMFG CYB5R1 APOD BRI3BPTP53INP2 ZNF280B GMNN ACOT1 /// ACOT2AKR1B10 PCDH1TP53TG1 ZNF280C GNAI1 RNF167 FLJ38717 ZNF10TP53TG5 ZNF280D GNAS DDHD2 AGAP11 /// AGAP4 /// AGAP6 /// AGAP7P /// CTGLF12P /// LOC101060581MMP24OSTPI1 ZNF304 GNB5 CDC5L RBM26 ZNF26TPP1 ZNF329 GNE ADAM8 HIST1H3C ERCC8TPPP3 ZNF362 GNG10 CLGN UBE2D4 CSNK2BTRAF3 ZNF382 GNG7 DNAJA2 RP4-539M6.14 RACGAP1TRAF3IP2 ZNF385D GOLGA8S PSG2 LINC00616 COPG2TRAF5 ZNF398 GP1BA GMIP P2RY14 TMEM164

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TRAPPC2 ZNF415 GP2 CD2 LOC441081 TMEM106CTREM2 ZNF417 GP5 MRPS12 ABTB1 PLCXD3TRERF1 ZNF419 GPBP1L1 DIMT1 PSME3 YAE1TRIAP1 ZNF432 GPC1 RTN1 MIRLET7D USP8TRIM45 ZNF441 GPD1L PRKD3 TRIB3 MTMR6TRIM65 ZNF461 GPLD1 FMNL1 LINC00639 PEX13TRIM7 ZNF484 GPNMB ACRV1 KMT2A /// LOC101929115SLC30A9TSEN2 ZNF487 GPR124 ALOX12 TUBA1A TRIM68TSFM ZNF497 GPR125 PRKAB1 BC062763 FBXO42TSN ZNF502 GPR155 PAK7 PPIA EEF1E1TTC17 ZNF510 GPR34 LYPLA1 CORO6 ZMYM6TTC19 ZNF529 GPR37L1 QTRTD1 LOC728353 EHBP1L1TTC32 ZNF534 GPR61 TERF1 EXOC3 FAM222A-AS1TTC39B ZNF543 GPR63 PDSS1 TTLL6 ZRANB1TTLL1 ZNF549 GPR68 GTF2E2 DDX49 BRAPTUG1 ZNF566 GPR84 PYGM ABHD13 ATL2TXNRD1 ZNF585A GPR85 PTK7 DNAJC14 SLC25A51TYRO3 ZNF586 GPR98 MRPL41 SPRR3 ITCHUBAP1L ZNF608 GPRC5B CYP17A1 PDSS2 IKUBD ZNF618 GPX4 LTBP2 LOC101060363 /// PPIAGCNT4UBE2G2 ZNF620 GPX7 PRX C11orf53 ADAM17UBE2N ZNF629 GRAP AGRP LOC101929718 CDK7UBXN8 ZNF639 GRAPL PHB2 PRMT2 PTGFRNUCN ZNF655 GRASP EXO1 ANKRD50 GSSUCP2 ZNF660 GRB14 BBC3 /// MIR3190 /// MIR3191C11orf48 /// LOC102288414SYT4UGT2A3 ZNF665 GRHL2 USP5 TRIM36 USP16UGT2B15 ZNF667 GRHPR ZNF391 CHN1 RAD9AUIMC1 ZNF709 GRID1 WDR44 RMND5B MON1BULK2 ZNF710 GRIK4 CUTC BCL2L13 TEFULK3 ZNF711 GRK4 DPM1 MTMR2 LPCAT1UMPS ZNF726 GRM2 CIB2 XRCC4 OSTCUNC5CL ZNF740 GRM3 TMEM30B CTC-429P9.3 MAFURB2 ZNF764 GS1-124K5.4EXTL1 LOC102723704 PSD4USF1 ZNF773 GS1-166A23.2ACYP1 SNRNP70 TSPYL2USP28 ZNF774 GSDMB OSBP RHPN1-AS1 PURBUSP38 ZNF776 GSDMC SLC25A38 LMO3 ZNF829USP43 ZNF777 GSDMD ADORA1 BLOC1S3 C1orf109UTP20 ZNF8 GSG1 FUCA1 DUSP3 AMPD2VASH2 ZNF812 GSTA1 EEF2 LAMB3 CLPBVAT1 ZNF846 GSTA2 TNK2 LOC284669 VAMP4VAV1 ZNF853 GSTA4 PRKAR1A KCNV1 ZNF841VCL ZP3 GSTM1 TMEM208 IFFO1 DDX49VCP ZRANB1 GSTM2 SPIB CFD HMGB3VDR ZSCAN25 GSTM3 ALX4 KIZ /// PLK1S1 SLC52A2VIM ZUFSP GSTM4 CNGB3 TYW3 MTRRVIPAS39 GSTM5 ABHD11 ITGB2-AS1 TMUB1VPS25 GSTO2 GPR157 FRG1B PAPOLAVPS35 GSTP1 CBWD1 /// CBWD2 /// CBWD3 /// CBWD5 /// CBWD6 /// CBWD7 /// LOC101060578HERC2P2 /// HERC2P9C1orf43VTCN1 GSTT1 KPTN CUL1 QPCTLVWA5A GTDC2 FAM49B SYNE1 PTBP1

Page 61 of 781 Diabetes

WASH5P GTF2H5 C1GALT1C1SPRTN MAFGWASL GTF3A DUSP11 TNRC18 ZNF527WDR25 GTPBP2 APOO SLC30A5 INSWDR3 GUCA1A EEF1G /// MIR3654AP1G2 UNC5CWDR31 GUCA2B SLC39A6 TYK2 LRP5WDR37 GUF1 GPX5 ALG10 FUBP3WDR6 GULP1 CPD CHML GSTK1WDR70 GUSB SNRPN /// SNURFIDUA TXNDC9WDSUB1 GYS1 HIGD1A PPFIBP2 ZNF75DWIPF1 GZMH TASP1 KIF3B B2MWLS H2AFY C6orf120 AGFG1 TKTWNT2B H2AFY2 H6PD METTL21A GDI2WTAP H6PD DBT GNAI3 VAV3XKR4 HACL1 CES1P1 VDAC2 TLE2XPC HADH RCHY1 AP1G2 /// JPH4 BNIP3LZBTB16 HAGHL CDS2 SNX31 OIP5-AS1ZC2HC1A HAPLN3 PRKAA1 DYNC2LI1 TEX30ZC3H12A HAS1 RBM3 FECH CFC1ZC3H12C HAUS4 FABP7 CTSF PSAT1ZCCHC7 HCFC1 PTDSS2 PKN1 BAMBIZFAND6 HCFC1R1 DYRK2 UBE2V2 LAPTM5ZFP2 HCK CDK7 BLMH RAVER1ZFP3 HCN4 C22orf24 TRIB1 CTSBZFP62 HCST CYP2A7 MPV17 ZMYND19ZFP90 HDAC11 SNRPB C4orf19 FBXW8ZGLP1 HDAC5 GLRX3 MOB4 KANK1ZKSCAN1 HDDC2 ADD3-AS1 APOLD1 HMGCLL1ZKSCAN8 HDDC3 ZBP1 PLB1 RGP1ZMAT1 HDGF AKAP9 FZD1 NIFKZMPSTE24 HDLBP MXRA7 LOC100507006 UBTD1ZMYM3 HEBP1 TMEM209 TRABD COLCA1ZNF112 HECTD3 MMP26 GAR1 GDF11ZNF135 HELLS BARX1 ASAH2B ABATZNF174 HELZ2 SKIV2L AX746710 COL4A1ZNF177 HENMT1 CLINT1 KLHDC4 /// LOC100129637FLT4ZNF202 HEPACAM2SYT12 NENF SLC7A1ZNF234 HERC2 SRP19 LOC100287166 /// LOC101930064USP38ZNF239 HEXB PGF BC040624 /// FOXP1-AS1 /// FOXP1-AS1FOXRED1ZNF248 HEXIM2 CHI3L1 FCRL2 RXRGZNF25 HEY2 RGR GFER TIMM21ZNF263 HEYL GIPC1 SMEK2 CMSS1ZNF285 HIATL1 PTAFR RP11-196G18.24 SMARCC2ZNF3 HIBADH ZNF783 TMEM212 RTCBZNF30 HIBCH C1D ARPC5 C1orf174ZNF311 HIC1 GRAP SLC11A1 SERF1BZNF32 HINT2 RANBP6 PDP1 STRAPZNF345 HIRIP3 TWF1 C19orf33 LINC00673ZNF362 HIST1H2BJ CASD1 C3orf52 SORL1ZNF404 HIST2H2AA3GRK5 CALCA TIGD5ZNF418 HIST2H2AA4SEC24D AGAP6 UTP6

Page 62 of 781Diabetes

ZNF429 HIST2H2ACTSSK1B HMGN3 WAC-AS1ZNF431 HIST2H2BEIL1RAPL1 EBP MAGI1ZNF449 HIST2H3A GRB10 LOC388692 SATB1ZNF487 HIST2H3C IFNA16 RGS11 ILVBLZNF525 HIST2H4A MZT2B MYL6 NUAK1ZNF527 HIST2H4B YEATS4 PCED1A DKC1ZNF564 HJURP MRFAP1L1 PEX2 FIP1L1ZNF565 HK1 BMP7 DNAJC12 UBALD1ZNF589 HK2 PPP1R14D LOC100506124 /// TTC21BCDH5ZNF595 HLA-A PLXNA3 RAB11FIP5 SAFB2ZNF606 HLA-B TYR PHACTR3 SOD1ZNF623 HLA-C ZNF286A KRT18 FKBP15ZNF641 HLA-DMA SNF8 PLEK2 HOMER1ZNF662 HLA-DOB SLC34A1 YARS2 TNS1ZNF70 HLA-DPA1 DDX3X SPSB3 ASB1ZNF763 HLA-DPB1 CAAP1 YWHAG EDARADDZNF823 HLA-DQA1 NR1I3 ZNF681 SEC24DZNF835 HLA-DQA2POLR2J /// POLR2J2 /// POLR2J3 /// UPK3BLC1orf43 URB2ZNF862 HLA-DQB1 IBTK DOHH CFAP20ZNF92 HLA-DQB2 TTC33 MYL12A /// MYL12B SETBP1ZNF93 HLA-DRA EPB41L3 BTF3 LINC00294ZNRD1ASP HLA-DRB1 IL1RAPL2 UTP3 TCP1ZSCAN20 HLA-E APLNR SNX21 ARFIP2ZSCAN21 HLA-F CD70 SDC4 RING1ZSCAN32 HLA-G SNRPD3 RP11-846E15.4 TAF4BZSWIM8 HLTF RTN2 LOC100288974 /// MBL1PC12orf57

HM13 KDM6B CABIN1 ARIH1HMBS FZD6 AGAP4 ORC4HMGA1 ENTPD1 SCAMP3 USP1HMGB3 KLK13 GSTM1 RUNDC1HMGCS2 RIN1 CYAT1 /// IGLC1 /// IGLV1-44MTDHHNF1B KCNA1 KLHL15 LOC643072HNRNPLL OR10C1 PXMP4 CBWD2HOMER2 PRUNE2 COX7A2P2 /// COX7A2P2CYP2J2HOMER3 ANAPC10 CHAF1A CDC42EP4HOPX INF2 PLXND1 PPP1R15BHPDL ZMYND11 RP11-319G9.3 MFSD9HPS3 FAF1 UNC5C IRS2HRASLS MMADHC RBP7 PSMD13HRSP12 BDKRB1 ZNF616 SF3A2HS3ST1 SF3A2 VAV2 MTA2HS3ST3B1 VIM FUCA2 AKAP8HS6ST1 GTF2B LOC574538 RAB33AHSD11B1 ELANE MLF1 LNX1HSD17B14 KRT5 ZNF251 CD59HSD17B2 EIF4G2 NAA15 WDR90HSD17B4 PPP2R3C RANBP6 NBR1HSD17B8 EPPIN /// EPPIN-WFDC6MBNL1-AS1 POM121HSD3B2 PHLPP2 NDUFA12 SUPT7LHSDL1 CALHM2 LOC100506497 MRGPRE

Page 63 of 781 Diabetes

HSDL2 CLCN1 LOC102725017 SENP3HSF2 DIAPH2 PSMB4 IGFBP4HSPB1 SIN3B CWC27 HGDHSPB6 COG2 SLC25A5 DNAJC7HSPB7 RSRC2 NIFK SETD1BHSPB9 LA16c-381G6.1CDK7 ZNF674HSPE1 RPS18 SF3B6 SRSF8HTR1F EDA2R EIF4B TRMT44HTR2B CDC25A POLR3D SCG2HTR3A IGHG1 /// IGHMSTAB1 PDHXHTR7 HYAL4 CABLES1 UHRF2HUNK ATP2A2 LOC102724094 ATP9AHYAL2 RCBTB2 FAM208A KAT2AHYKK FZR1 RNF6 PARNHYLS1 GPR52 KRT7 C18orf25ICAM1 CHRNB2 FAM95B1 /// LOC101928261 /// LOC102724314MAML3ICAM3 ZNF574 RPL36A /// RPL36A-HNRNPH2ZNF12ICAM4 TBK1 RNASET2 ST6GAL1ICAM5 RP3-497J21.1AIFM2 DBIICMT SPG21 ZNF627 CCPG1ICOSLG HSD17B10 MYO15A RBM48ID4 YTHDC2 LINC00930 TSNAXIDH1 GMEB2 PIK3CB AURKAIP1IDH3B MAT2B GUSB ARMC6IDO1 HIST1H1A RAB31 UBXN8IDO2 KCNMA1 PIGL ZRANB3IER2 ZNF771 SEPT11 CEP120IER3 NCOA4 LINC01214 TMEM132CIER5 ASCC1 FAM32A KREMEN1IFFO1 WDR62 IGF2BP2 TIMM23IFFO2 PLS1 IFT80 GOLGA4IFI16 RNF38 MRPS7 NUP35IFI27 EVI5 ASNSD1 KCTD20IFI30 AARS COMMD2 LAPTM4AIFI35 ERBB2 TFF1 RDH13IFI44 GNB2L1 /// SNORD95 /// SNORD96ADNAJB11 INHBEIFI44L ATP6V0B TMF1 SLC29A1IFI6 SACM1L GPR176 GCH1IFIH1 SSBP1 TMEM203 DDB1IFIT1 PRKG1 MIR4800 /// MXD4 TMEM50BIFIT1B DIP2A RP11-539L10.3 SMAD4IFIT2 NPHP4 LOC100128554 SDHAF1IFIT3 FBXW11 LOC101928327 CHCHD4IFIT5 FAM66D STS ACAA2IFITM1 BLK NUFIP1 FBRSIFITM10 PPFIBP1 SOX1 RFC4IFNGR2 SYNCRIP FADD CELSR2IFNLR1 UGP2 IGKV1OR2-108 /// IGKV1OR2-108KLHL15IFT172 SCAMP3 GATA6-AS1 PNMA1IFT20 OXSR1 AGPAT2 CYLD

Page 64 of 781Diabetes

IGFBPL1 MICALL2 DSCAM-AS1 ZNF44IGFLR1 AP1AR BRI3 CNSTIGLL1 GOLGA7 MRPS12 GLTPIGSF11 PPIB KRT8 DNAJB12IGSF23 ZNF611 TRMT12 EPAS1IGSF9B UFL1 POR MAP1LC3B2IKBKE ANXA2 /// NHP2L1ATG5 AP3M2IL11 ATP2B2 LMO1 ATP5MC3IL12A WRB BRD7 PXDNIL12RB1 HINT1 TTBK1 EIF2B2IL15 BCAS1 SLMO2 MMP24IL15RA CHD3 C21orf15 ZNF274IL16 ART4 DOLK LRFN2IL17C EIF3A FIGN VIRMAIL17D COPS3 LOC100506469 NLRC5IL17RD DMC1 GOLGA2P5 GBAIL17RE TNNI1 ACTA2 /// ACTA2 STRIP2IL18 C9orf3 SF3B1 PUS7LIL18BP CNOT2 C6orf58 PTPRFIL19 TMEM33 GPN2 TADA1IL1A YIF1A MRAP2 CCDC146IL1B SIRPB1 COX17 ZNF548IL1RN CSTF1 NIPAL2 GLRA1IL20RA CAPZA2 ARSG CYB561D1IL21R KCNJ1 PIGM FZD1IL23A DRD1 TSR3 ASCC3IL27RA ACTN2 MAATS1 BMS1IL2RA PGAP1 NECAB2 CARM1IL2RG SEC11A AK4 /// LOC100507855HFEIL32 TP53AIP1 NEDD8 FZD4IL33 LOC101060363 /// PPIAALAS1 FBXO36IL36G KIAA0196 CCNT2 CNKSR2IL36RN GMPR2 GPR153 GORABIL4I1 KHSRP GRIA1 NPPA-AS1IL5RA MYO9B USP39 ELP3IL6 APIP HEBP2 RGS2IL7 SAR1B TTC14 AAMPIL8 TFDP1 FKBP1A-SDCBP2 /// SDCBP2ZNF783IMPA1 RP11-680F8.4ACADVL SGCBIMPDH1 NDUFA5 COG8 /// PDF PDLIM1IMPDH2 MEX3D MCCC2 PLXDC1INA YIPF6 SIN3B MTHFD2INCA1 GPSM3 TACR1 MLF2ING1 RNF34 EBF4 CASC4ING2 HTR1A C8orf59 CCDC40INHBC SLC38A3 TAC1 C5orf66INPP5A LRCH4 /// SAP25COL28A1 PRKCQINPP5F POLG DSTNP1 /// DSTNP1 MOKINPP5J MYB RAB1A AAK1INSM2 ARHGEF28 TRAPPC1 BFAR

Page 65 of 781 Diabetes

INSRR BIRC7 DHX36 ZNF568INTS10 GCG PTCHD1 CXorf40BIP6K3 RPLP2P1 /// RPLP2P1STARD7 BOLA2-SMG1P6IQCC CCR8 AP1S3 TMEM119IQCH-AS1 ALS2CL LINC01355 LOC100130283IQGAP2 TRIM37 MCTS1 PLEKHM1IQSEC3 ARHGAP6 CTB-78F1.1 AHSA1IRAK2 IL19 LOC100133130 PARP14IRF1 APOL1 ARHGEF7 NECTIN3IRF2 SMAD4 POMT1 RBSNIRF2BP2 COX11 NKAP SHQ1IRF2BPL CYCS THEMIS2 RNF167IRF7 CNOT7 BBIP1 /// LOC100130175ZNF566IRF8 MAST2 OSTC DHX40IRF9 SSX2 /// SSX2BAPOL4 ZNF398IRG1 RPL35A ME1 SETMARISG15 HOXC11 RPP30 FAM220AISG20 ELSPBP1 RBM45 MCHR1ISLR COPE NUDCD1 RPF2ISLR2 TBL2 PRMT6 IGFBP5ISOC1 CUL4B LINC00511 /// LINC00673MFFITGA11 RNF122 OTOGL CLN6ITGA3 MKS1 PSMD11 TOMM20ITGB1BP1 BLM WDR27 CLDN15ITGB5 TMEM248 CHCHD1 CRAMP1ITGBL1 CTLA4 GLB1L TP53BP1ITIH6 FOXD2 LOC101929114 NSUN4ITPKC IMP4 LRRN4CL TLR5ITSN1 SCG2 BID NR2F2IZUMO4 CACFD1 AP000462.1 BMP8AJAG1 DNAJC12 CYB5R2 ABCF3JAG2 ST8SIA5 GSTM2 CHST2JAK2 SLC39A14 TNFAIP8L3 ZNF230JAK3 PPP3CB ZNF576 ATP6V1DJAKMIP3 FGF5 FKSG49 NOP14JPH4 RHBG ZNF638 /// ZNF638-IT1RAPGEF3JUN CDR2L PLGRKT PARLJUNB OR2H2 KXD1 SPRED3KANK4 EIF5 FRMD4A CDC40KARS PTPN11 CENPQ SH3BGRLKAT2A ZNF468 RAD52 ANKRD40KAT2B LAT2 GCHFR SUSD1KAT8 SLTM SLC12A5 ORMDL1KATNA1 LIPA IPW /// LOC101930404 /// PWARSN /// SNORD107 /// SNORD115-13 /// SNORD115-26 /// SNORD115-7 /// SNORD116-22 /// SNORD116-28 /// SNORD116-4 /// SNRPNFCF1KATNAL1 SMAP1 PEA15 PIP5K1AKB-1183D5.14GRSF1 CYP20A1 PLXNA2KB-1592A4.14IQSEC2 ANKRD28 PLUTKBTBD11 MLPH ARRDC4 ZNF253KCNA5 ITPK1 SWAP70 USO1KCNE2 TMEM59L SSX1 CDH24

Page 66 of 781Diabetes

KCNG3 DCC EIF4H PDXDC1KCNH2 APPL2 KARS UBXN1KCNH3 EDF1 SLC26A10 CDC73KCNJ11 CHPT1 ZSWIM1 CALCOCO2KCNJ16 VAMP5 MCEE ZNF787KCNJ4 TRIM13 HIST1H3G STN1KCNJ5 RPA2 PTDSS1 PPIL4KCNJ9 FOXP3 LUC7L3 TSTA3KCNK16 PHOX2A KPNA4 ZBTB8BKCNMA1 TJAP1 TMEM182 PAK1IP1KCNU1 LOC728392BOLA2 /// BOLA2B ZNF451KCTD14 LOC101927770PRKCB LOC93622KDELC1 NUPL2 VAMP7 RSL1D1KDELR1 ARMCX2 ALOX12P2 LIN37KDM6B FBLN1 ZNHIT3 CDHR1KEAP1 KANSL2 FLJ41455 MUL1KHK PDCD1 YIF1B FGGYKIAA0040 DNASE1L3 LOC101927391 FURINKIAA0100 DGKI SYT9 FZD3KIAA0196 SLC4A1 MCM3 PPANKIAA0247 ENTPD5 RPF1 GCHFRKIAA0319 MTRR CCDC93 CIAO1KIAA1143 PRR11 TRPM5 MXD1KIAA1217 FIS1 ABHD14A-ACY1 /// ACY1ZBTB21KIAA1239 FZD5 MIA2 CMIPKIAA1257 GPR20 C16orf91 RSAD1KIAA1324 STATH BDKRB2 ZNF605KIAA1429 CCBL2 CACUL1 SMU1KIAA1462 SAE1 UBR5 EIF4A3KIAA1614 HIST1H4I QSOX2 CCT6AKIF12 MIR1304 /// SNORA1 /// SNORA18 /// SNORA32 /// SNORA40 /// SNORA8 /// SNORD5 /// TAF1DRBMXL1 UBE2J2KIF20B CDHR5 CASP3 UQCC1KIF23 ACTR1A DOLPP1 CEP192KIF26A GABRB2 PCDH12 DDX39AKIFC2 LOC100288570F12 HINFPKIFC3 CXorf57 TMED5 DAPK3KITLG TBX1 PPP1R2 PPIP5K2KLF15 BMP1 RAB10 GPM6AKLF4 ZCCHC14 PGM3 SGTBKLHDC3 ABCB9 NQO2 GAS2L1KLHDC7B HOXD9 RTEL1-TNFRSF6B /// TNFRSF6BGPR89AKLHL23 OR5I1 INTS3 ZC3H18KLHL30 GRM3 SLC25A28 ATP2B4KLHL38 DNM1L RNASEH2A FKBP5KLHL4 TRA2B AHSP FZR1KLHL7 PRPF18 ARHGEF15 HPRT1KLK4 ODC1 MMAA IBTKKLLN DNAJC9 CCDC84 CDK20KLRG1 CCNJL MRPS6 LOC101927151KNOP1 PITPNA TMEM259 BAG6

Page 67 of 781 Diabetes

KRCC1 RNASE2 NAGS PODXLKRT1 MEF2A LOC100130428 PAF1KRT18 GPR4 TVP23A RNF168KRT40 XRCC6 STARD9 SUCLG1KRT6A CLCF1 RP11-307L14.1 /// RP11-307L14.2RMND1KRT6B PSMA3 PRO1804 RECKKRT6C WDR55 EWSR1 CCDC47KRT8 TBL1XR1 CDK5RAP3 TOMM70KRT80 RBM25 TH MARCHF2KRTAP1-1 WSB2 CUL3 PPP4R3BKRTAP2-3 PPA1 RPL7A /// SNORD24 /// SNORD36A /// SNORD36BSLC25A46KRTAP2-4 PIK3IP1 ENTHD2 LMF2KSR2 TTC9 LINC-PINT SUSD4KY STX3 NSUN6 ALMS1KYNU CEMP1 P2RX1 LRFN4L3HYPDH MFGE8 STK40 SBNO1L3MBTL4 CCR4 SLC25A26 YIF1BLA16c-444G7.2EVPL CDC42 MAN1C1LACC1 SS18 RBM42 ZBTB18LACTB DBH CYP1A1 GMPPBLACTB2 GREM1 C2orf69 PCDHGA12LAMA4 NDUFA7 LOC100131496 C12orf4LAMB1 CYP11B1 NPAS3 THOC5LAMB3 MAPK8 GPATCH4 TSC22D2LAMC2 CACNB4 TENC1 TASOR2LAMP3 NDOR1 CREBZF DENND11LAMP5 PRKCSH ARPC4 SELENBP1LAMTOR1 EIF3J LOC100422781 IGDCC4LAMTOR4 SERPINA7 LOC100506538 /// NDUFAF6PCYOX1LLAP3 RAB3IL1 OBFC1 UCN3LBH KCTD9 BRD7P3 PEG3LCE3D KLHL22 PCDHGA4 TRAF5LDHB LOC79999 ULK1 MPEG1LDLR SLC9A7 PCDH9 TRIP11LDLRAD1 EMR1 GSK3B WDR81LDLRAP1 EFNA2 FAHD2A /// FAHD2B /// FAHD2CPMECOMLECT1 B3GNT4 MMP10 DZIP1LEO1 PTPN21 ARHGEF4 /// LOC101930241MAP3K7LEPREL2 FRY EIF3D INTS10LEPREL4 B3GNT3 DIO1 RABGGTBLFNG SNX3 FAM129B DYNC2H1LGALS14 APOOL MIR6840 /// PILRB /// STAG3L5P-PVRIG2P-PILRBSNW1LGALS4 TP53I11 ERVH-1 RAB2ALGMN RNF14 KLRB1 PON2LGR5 KRT38 LRRC16B DHX16LIAS CDC37P1 /// CDC37P1RP5-855D21.1 BAIAP2-DTLIF BGLAP /// PMF1 /// PMF1-BGLAPNPTN-IT1 SLBPLIFR SNRPE DDX17 CPSF1LILRB4 EMC10 FBXW11 LINC02197LIMD2 GOT2 HPRT1 TTC3

Page 68 of 781Diabetes

LIMK2 PDLIM7 FAM66C /// LOC101928910ZNF587BLIN7B NGFR FAM135A ABHD18LIN9 CD1A MAPRE1 TIPRLLINC00205 MOAP1 HDHD1 PRKCZLINC00261 C2CD5 USB1 NBASLINC00315 GLRA2 SAFB2 ERHLINC00478 CCDC186 MROH7 PLD1LINC00595 PRPF4B ATP6V1D C5orf51LINC00605 AOC1 C2CD5 TIMM17ALINC00641 MRPL15 ASL NCALDLINC00662 AK021933 WIPF3 RBM15LINC00677 PNMA1 CLK2 NEURL1BLINC00683 TCEAL1 IGHA1 /// IGHG1 /// IGHG3 /// IGHM /// IGHV4-31 /// LOC100293211FKBP14LINC00704TMEM183A /// TMEM183BLINC00967 SEMA5ALINC00849 PEG3 NUDT1 SSBP1LINC00857 ADORA3 SAE1 MIA2LINC00880 ARF4 CDCA4 AMIGO2LINC00882 TNNT1 KLHL3 SPRLINC00883 RNASEL NOL10 PROS1LINC00930 SNX7 PIN4 GTF2H5LINC00948 DGCR6L RALBP1 PLSCR4LINC00958 PLCB2 VPS26A EMCNLIPG PLA2G2D C20orf24 /// TGIF2-C20orf24NPM1LIPH NOX5 NDUFA1 NR4A2LIPM COX5A BC043266 /// RP4-568F9.6ABHD10LITAF FUBP3 SLC25A24 ARF1LIX1L GABARAPL2PSMB3 RARSLMAN2L ANKFY1 C1orf116 KRR1LMLN FLJ22184 RBM5 EDC4LMO2 PLK3 ADAMTS12 RWDD1LMO7 SMARCA5 TTC28-AS1 FOXJ1LNPEP FCER1A LOC101929112 TTC26LOH12CR2 TFAP4 GTPBP4 /// IDI2 KCNK1LPAR1 C1orf159 KLF16 ADGRF5LPAR2 B4GALT5 CMAHP CSNK1A1LPAR3 DEFA6 RP1-118J21.25 CPSF7LPGAT1 CEP76 LINC01296 /// LOC100653149 /// LOC102725127C1RLLPHN1 LILRB1 RP11-792A8.4 PRRC1LPO INPP1 CX3CR1 CLCC1LPPR1 MKKS CERS1 /// GDF1 ANKIB1LRCOL1 GAD2 LOC100133039 NXF1LRFN1 CETN3 DKFZP586I1420 RPS6KA1LRFN4 CTB-102L5.7GNRHR2 TCEA1LRP10 NDST2 /// ZSWIM8-AS1SLAIN2 RHOBTB3LRP11 BCL3 /// MIR8085FOXC2 TGM2LRP1B CBFB KCNAB1 SLC6A9LRP3 MFN2 SRR PAK1LRPPRC FBXO3 B3GNT7 LPAR6LRRC17 AMH /// MIR4321INIP ZNF324BLRRC20 ART1 NDUFS3 RCAN3

Page 69 of 781 Diabetes

LRRC26 BARX2 CD52 ZNF324LRRC32 HLX TAPT1-AS1 NUDT22LRRC34 GLYAT VPS9D1 DUBRLRRC36 PACSIN3 VPS13A ZZEF1LRRC39 PMEPA1 TUBA3C /// TUBA3D MCM7LRRC8D GRIN2B CCL20 SURF6LRRN1 CRYZ PIGA KHDC4LRRN4CL PSD3 CLP1 FBXO16LSM2 NARS2 C7 UBE2D2LSMEM2 ATP6AP2 ANK1 UTP18LSR CORO7 TSPY1 ZNF621LTA BTF3 NR0B2 LSM3LTBP1 RP11-403P17.4ENGASE DNAJC16LTBP2 TMEM131 SQLE MED29LUCAT1 HSD17B11 PON2 CCNHLURAP1L ZC3H7B NHP2 SPRED2LY6E ZFC3H1 ENOPH1 MON2LY6G5C IL3 TTC18 INTS4LY86 MDH1 SFN TTC9CLYN CTSO ZNF638 PPM1GLYPD3 HNRNPF LRRC59 MLLT3LYPD5 MEGF9 TIPARP USB1LYSMD4 ZNF721 DKFZp434J0226 SLC25A42LYVE1 EEF1D LXN ARMCX3MAB21L1 RTEL1 FAM160B2 C1orf127MACC1 HOXA10-HOXA9 /// HOXA9 /// MIR196BC5orf22 DOCK4MAFA BCL7A TCTN1 NME7MAFF ASXL2 CSF3R MTRF1LMAFK CSPG4 CYP21A1P /// CYP21A2IKZF5MAGED1 TLE6 PLP2 EVLMAGED4B MRPS27 KATNA1 HNRNPUL1MAGEE1 KRT33A RAPSN LYNX1MAGEH1 GNE SEC14L2 RASSF6MAGT1 PLA2G3 TMOD3 CORO1BMAMDC2 C14orf132 LYN DISP3MAML2 TNFRSF8 COQ4 VAPBMAN1A2 EVC NUDT15 ARCN1MANBA MBTPS2 /// YY2LARP1B UGGT1MANSC1 ELP4 ERO1L C11orf58MAOA MRPS11 RAB38 AZIN2MAP1LC3APUS7 PSMB8 SEZ6MAP2K3 ERLIN1 UGP2 CD99L2MAP3K12 CDC45 CDH12 SUFUMAP3K15 EBF2 MCF2L-AS1 ZBTB43MAP3K8 TMBIM6 CD82 TPT1-AS1MAP4K2 PRODH2 MYO1E BDH1MAPT LGR5 CERCAM CHCHD3MARC1 AGA SNX6 SAMM50MARC2 CMTM6 IRF8 ADKMARCKS CTSC GZMH NBR2

Page 70 of 781Diabetes

MARVELD1PQBP1 HNRNPA3 ENTPD1MASP1 FLCN PTP4A1 RPS19BP1MAST1 EIF3E LOC101928189 /// RSRP1FANCFMAST4 TMEM104 JUP SEC61GMAT2B ELF5 GOLGA7 WHAMMMATK DUSP12 GS1-164F24.1 ITGA1MATN2 EFEMP2 MELK INKA2-AS1MATN3 HIST1H2AG /// HIST1H2AH /// HIST1H2AI /// HIST1H2AK /// HIST1H2AL /// HIST1H2AMGSAP RNF113AMB NLRP3 MSH5 /// MSH5-SAPCD1 /// SAPCD1RPN1MB21D1 FAM118A EPPIN /// EPPIN-WFDC6C14orf93MBD6 CDC123 MYO18A /// TIAF1 LINC01843MBOAT2 ZNF451 G3BP1 DENND3MCCC1 ALDH1A2 MAPKAPK2 DNAJC1MCF2L2 NDUFB6 UBN2 WIPI2MCL1 KLHDC4 LOC730102 SEMA4GMCM6 CASS4 ALDOC ATAD2MCOLN3 SLC6A8 CLVS1 GKMCTS1 AC068039.4BZRAP1 FAM126BMDFI KCNS1 RGS1 SLC17A9MDGA1 PYHIN1 PEX26 PICK1ME3 ZNF330 CD1C TRIM21MEAF6 UQCRFS1 IRAK1 MINDY1MECR TNPO1 PLEKHA3 SACM1LMEF2C TMEM50B PTPN4 ARL5BMEGF11 RTN3 PRPF4 MATN1MEGF6 DSCR4 LOC101929855 /// LOC102724851JUNDMERTK GRAP2 MLLT4-AS1 CDK11BMESDC1 CD3D LOC285419 DYNLT3MESP1 LEP FAM114A1 PHF5AMEST MTCH2 LRFN1 AP4B1METRN SIRPA CHMP4B BAIAP3METTL10 LOC101927051CENPT SIX5METTL17 TBC1D9 TEX30 ATOH8METTL20 DENND1C CHD2 FKBP9METTL7A SLC13A4 EPHB2 MBOAT4METTL7B CTC-338M12.4JAGN1 SMN1MEX3A RP5-1170D6.1DFFA TRNP1MFAP2 POT1 LOC102724275 FBXW2MFF NCKAP1L NQO1 RPTORMFNG EPB41 RP11-295G20.2 SNX2MFSD2A AOC3 RASSF1 TYW1MFSD3 TBCE RP1-151F17.2 ZFP36L2MFSD6L TM4SF5 DCTPP1 STAB1MGAT2 USB1 OBSL1 SLU7MGAT5B ATP6V0A4 ZFAS1 ZMYND10MGC20647NCAPH2 GABBR1 PLA2G12AMGMT B4GALT2 CD74 FOSBMGP RBM38 C4orf32 CRIP2MGST1 ARMCX5 CCBL1 NEPROMICAL1 MIR3658 /// UCK2LOC101928483 NCBP1

Page 71 of 781 Diabetes

MICALL1 IGHA1 /// IGHA2 /// IGHD /// IGHG1 /// IGHG3 /// IGHM /// IGHV4-31USP32P2 ZNF184MICB IGLJ3 /// IGLV3-19 /// IGLV3-19SRFBP1 METTL1MICU2 LOC100505498LOC101928424 ELK1MIDN DTWD1 ELOVL5 THOC1MIER2 STXBP1 EEF1E1 SLC25A25MIF4GD ABCD1 SEC13 CEP350MIR143HG CRNKL1 MFAP4 CBWD5MIR146A MYBPC3 CEP44 SPEF2MIR155HG C20orf195 RPN2 STX4MIR24-2 PDE3A NUP37 CANT1MIR4720 PER2 NPHP4 TBRG1MLF1IP IQCA1 FAHD1 PTPRUMLKL PARL NAV2 NOM1MLST8 PTPRN2 TRAM2-AS1 CROTMLXIPL DRD5 BCL10 TRAPPC12MMAA ACAA2 RP11-873E20.1 ADIPOR1MMACHC HOXB1 PRMT5-AS1 UNC119MMP1 HOMER3 LOC101930630 /// STRCMBD2MMP10 DERA DENND3 TXNDC5MMP11 EIF3D ACTR3C CD14MMP15 GRIA1 SMPDL3A TNS2MMP25 SRCAP LOC102724975 SRRMMP3 FASTKD3 WNT10B MX1MMRN1 SKIL CSNK2A1 CHST9MMS22L RAB6B Y16709 TSPAN14MN1 DBF4B MED6 EIF2B1MNX1 SCGB2A1 CDK6 ECHDC3MOB1A LILRB3 MAL2 FKBPLMOB3C SRRM1 HDC DNMT3AMOCS2 CASP4 ZNF174 RNF5MOV10 ADH7 TOMM40L IL10RBMOXD1 RCN2 DPP3 TGFBR3MPC1 CCL22 MAPK1 HEXBMPG PLA2G2F MFSD2A SLC25A53MPP1 RPL15 IGHV5-78 PBXIP1MPV17L GFAP GSR CACUL1MR1 SLC35E3 CYTH1 RANGAP1MRAP2 HPCA LOC100128288 INPP5FMRGPRX3 PDCD6IP ZRANB2 TMEM11MRM1 SNRNP27 GRIA4 METTL16MROH7 SAMHD1 PTPMT1 CCDC88CMRPL12 C11orf73 LINC00893 /// LINC00894GCN1MRPL14 VCY /// VCY1BCDK10 EARS2MRPL15 GDPD3 TMEM33 ZBTB5MRPL24 NFE2L2 HAUS1 ATG5MRPL34 RRN3 DUSP14 MMP15MRPL40 REST AIFM1 TSHZ2MRPL48 LINC01314 MGC4294 ROGDIMRPS2 ZFR2 CAPN3 TRIM39MRPS26 AFF2 C19orf26 JADE1

Page 72 of 781Diabetes

MRPS27 MB ADAT1 NDNMRPS34 CSNK1G3 CXCL8 ST3GAL2MRPS7 PBOV1 CDK14 GNG10MS4A6A TRAPPC13 MAPK8 ST3GAL5MSRB1 IKBKE ATP5J2 VKORC1L1MSX2 TRAIP RBM17 CAMSAP1MT1E ETNK1 ADAP2 CEP83MT1F CD79B DEFB124 MYO9AMT1M SLIT2 TBC1D2B SPATS2LMT1X APOC2 /// APOC4 /// APOC4-APOC2BRI3BP /// THRIL DXOMT2A CARKD SRP14 TXNL1MTA1 HBS1L RP11-796E2.4 ZNF850MTCP1 SMG5 ITPR3 PWWP2BMTF1 WIZ CCDC101 SESN2MTHFD1 PTPRD TTC31 LRRC4MTHFR MYOD1 TMEM38B KDM2BMTIF3 REV3L EHMT2 TXLNGMUC15 SSTR5 POLR3C HEYLMUC16 ERP44 RP11-135A1.2 C7orf26MUC20 MAGEH1 LOC646014 TRIM35MUC4 MKL2 TSG101 PDE4BMVB12B PAAF1 KANK1 SLC1A4MX1 DMP1 RPS6KA1 CSNK2A1MX2 CDC73 RP2 ISY1-RAB43MXD1 SNTB1 LOC101928173 CHPFMXD3 SCCPDH EME2 RASA4BMXRA7 GLOD4 SARNP TNPO3MXRA8 SEPT11 MSANTD3 SMARCA4MYCT1 HMBOX1 SCN7A OCIAD1MYD88 DCUN1D4 DDA1 C8orf33MYEOV SPCS2 MST1 HYKKMYEOV2 CYP4A11 ZBTB6 TERF2MYH6 OR1E1 /// OR1E2ODF2 ACBD7MYH7 TNFSF12 /// TNFSF12-TNFSF13LOC100130417 ALG14MYL6B LRRN2 COA7 FAF1MYL9 RNF185-AS1LOC100130429 TRIB1MYLK3 TOR1B LOC100129518 /// SOD2SLC37A4MYO1B USP34 ELF3 RSPH3MYO1G ACLY LOC285889 DOK3MYOCD NPFFR1 ACVR2A PDIA6MYOM1 WWP1 AC012065.7 RBBP5MZF1 KISS1 CD69 FEM1AMZT2B VRTN TMEM62 HEATR5AN4BP2L1 ORC5 LOC101928288 SLC25A30NAALADL2NRG2 LHX4-AS1 ATP1B1NACA ZNF160 LINC01420 SOX13NACC2 SASH3 HN1L DNPH1NAE1 TAF1C STX3 TRPM4NAGK SLC19A3 SMOX ARL6IP5NAGS TNS4 HNRNPAB CDK4

Page 73 of 781 Diabetes

NAMPT DCAF4 S100B C16orf71NAMPTL OSBPL7 FOXJ3 MAP3K10NANOS1 ADRA2B CHRM3-AS2 ZNF432NAP1L3 GLUD1 ANKRD10 FGD5NAPA FZD8 /// MIR4683GRPEL1 AVL9NAPEPLD MYOG YARS ANK3NAPG ASNS FRMPD1 MVKNAT8L ARG2 MRPL39 ATXN3NAV1 CYHR1 SLC6A16 LIMA1NBEAL2 DBET /// DUX4 /// DUX4L1 /// DUX4L2 /// DUX4L24 /// DUX4L3 /// DUX4L4 /// DUX4L5 /// DUX4L6 /// DUX4L7 /// DUX4L8 /// LOC100288289 /// LOC100291626 /// LOC652301RP11-61L19.3 MOCS1NBN RPS6KB2 IL17D METTL24NCCRP1 NAT2 CHRDL2 TBPNCF1 GGNBP2 AMFR BLOC1S3NCOA7 SPAM1 LYRM4 ABCE1NDC80 ENG GSTO1 MYORGNDFIP2 DPF2 PRICKLE3 PWP1NDN C22orf29 /// GNB1LRP11-138I18.2 PPP1R13BNDST3 NCR2 AMICA1 TPRA1NDUFA10 EPS8L3 OSER1 LURAP1LNDUFA11 DKC1 /// MIR664B /// SNORA56MRPL40 ZNF710NDUFA12 CHST5 GALNT16 STK11NDUFA3 KCNN1 LOC100506990 DVL3NDUFA9 LRRC40 AX748339 USP10NDUFAF6 TSPYL5 CTSW RASGRF2NDUFAF7 INPP5D ZGLP1 SRCNDUFB1 PLXDC1 TUBB2A /// TUBB2B EML2NDUFB10 TBC1D2 FOXD2 SNU13NDUFB9 TH KIAA1377 HAPLN3NDUFC2 REEP5 NDNL2 DDCNDUFV1 XPO1 SAMD1 SCAMP3NECAB2 S1PR2 ATOH7 CYB561NECAB3 HBE1 UBE4A SF3A1NEGR1 F12 SPATA18 NFICNENF CDK3 /// TEN1-CDK3CDK2AP2 ATP1A1NES GOT1 CSF1R NCMAPNEURL FCGR2C TPM1 MDM4NEUROD1 HDAC7 KRT8P12 OPRD1NEXN ATP6V0A2 ZNF367 EEF1AKMT3NF2 A4GALT MIR31HG ARHGEF28NFAM1 EGR4 TDRD9 TRIB3NFATC2IP NOP10 CLK1 PPARANFKB1 BTN2A1 YWHAZ HTRA1NFKB2 PLEC RRS1 EIF3MNFKBIA NEU3 LOC101930112 /// SPG7GID4NFKBIB RAPGEFL1 SUDS3 RAB1ANFKBIZ SMC4 MTFR1L ARPC5LNFYB ZFP36L2 ARNTL2-AS1 MAPK7NGFRAP1 IDUA C6orf164 FASTKD5NID2 RNF5 /// RNF5P1OPTN DMWDNIM1 EBLN2 CASK SDS

Page 74 of 781Diabetes

NIN SNAPC4 TMEM130 RGS4NINJ1 PLD1 LCN12 CD93NINL LRRC8B ZDHHC5 DOHHNIPAL2 IL13RA2 EIF4EBP1 SEMA6BNIPSNAP1 INPP5F BTN3A1 ITGB5NIPSNAP3BINS DRG1 STAG1NIT2 RHOD A2M-AS1 MYDGFNKD2 ABCG5 FAM96B CHMP7NKX2-2 ZNF614 CCDC18 DNTTIP2NKX3-1 HAND2 LOC283713 /// OTUD7ACOL15A1NLE1 FAT1 HLF AMOTNLRC5 DCLRE1C FAM156A /// FAM156BOLIG1NLRP12 MIR21 /// VMP1AKT2 DHFR2NME1-NME2DRICH1 CCDC25 STAT5ANME3 MRS2 SPTY2D1 PIEZO2NME4 ZNF460 C16orf86 GHITMNME6 TMCO3 AK054988 /// TPTE2P1 /// TPTE2P1FXYD6NMI TTTY2 /// TTTY2BRP1-102H19.8 NLGN2NMRK2 CNGA1 BC039673 TOGARAM1NMT1 ANO2 ELOVL1 /// MIR6734 EIF2S2NMT2 SESN1 RING1 LIMK2NMUR1 AMPD1 WDR73 LGMNNOD2 TNIP1 ACVR1 ALYREFNOS2 HLA-DOB MSS51 MFSD1NOSTRIN MAPK1 ZNF436 ZNF226NOVA2 ADRB1 PNP SPCS2NPAS1 TRIM15 MRPL32 RAB29NPBWR1 MISP RPRML RNF43NPM1 ATP5A1 PSME4 ABCC9NPM3 RENBP C19orf66 LMAN1NPPB DYNLT3 ZNF76 VPS4BNPRL3 BRAF /// KIAA1549MAU2 ISL1NPTXR MFNG DIAPH1 LINC01614NR5A2 NBN SERPINB2 DDX47NRARP ANXA2P1 BIN2 SUDS3NRGN DNAH17 SYNE2 LOC100996740NRIP2 LINC00597 C10orf2 OAS1NRK YIPF2 ATP6V1E2 /// FLJ41757ABCC1NRP2 LOC647070ATCAY GIHCGNRSN1 DBF4 ARNTL2 GTF2H1NRTN ARL3 EIF5 /// SNORA28 UBN2NRXN2 RABGGTA RRAS2 PMPCANSA2 C19orf40 SNAPC1 EAPPNSG1 KRTAP5-9 MECR ATP5F1ENSMCE1 SLC20A1 BC045788 LINC01534NSMF PMS2 /// PMS2CLCTBP1 NCS1NT5C3A EIF2B2 ZNF276 ROBO4NT5DC2 ZP2 MMADHC RAB11FIP5NT5M ZNF576 C21orf33 PPP6R1NTAN1 NAP1L3 FPR1 HIPK1

Page 75 of 781 Diabetes

NTHL1 DSE PRELID1 DDI2NTRK2 JAK3 PPTC7 RB1NUAK2 CDKN2AIP NFKB2 ARMH4NUB1 MAGED2 PPDPF ATG4BNUCB1 CHRNG NPM1P22 /// NPM1P22RTN4NUDT13 FBXO40 GLIS2 TMEM38ANUDT14 CALCR MIR34A RSBN1NUDT16L1 INHA MAP1A RPS6KB2NUDT3 ATG3 LOC101930578 /// TPTE2P2ARL5ANUDT8 CD74 PXDN DZIP1LNUF2 PRKAR2A PPP1R15A FAM114A1NUGGC RAI1 ZDHHC4 TMEM97NUP133 ARF3 ATP5I ZNF667-AS1NUPR1 XPC PIP4K2C ZNF454NUPR1L MGAT2 RGS3 MAEANYAP2 EIF3I FOXO1 REXO1OARD1 EFNB1 C12orf73 EIF3JOAS1 DRD2 HSCB FOXA2OAS2 TAF1D ME2 HOPXOAS3 GHITM PGGT1B CDC6OASL CD300A NRBF2 NIPAL2OAZ3 LIN7C SLC25A16 VPS54OBFC1 AKR1B1 MRE11A RIMS1OCIAD2 MIR6125 /// USP15MAPKAPK3 POLRMTODAM OCRL ATF7IP TXNL4AODF3B LIME1 KIF21A AKIP1ODF3L2 SCG3 TEN1 /// TEN1-CDK3 ENTPD7OGDHL HP RPGR LPPOGFR RSBN1 ADCK3 ISLROGFRL1 SHQ1 FAM153A /// FAM153B /// LOC100507387RAB22AOLA1 ECHDC3 SNRPF CMPK1OLFM2 EHMT1 ANXA3 AHCTF1OLFML2B CNN2 FBXO28 TIMM9ONECUT2 SH3GLB1 KRT72 INF2OPALIN PMPCA MLIP PDE6DOPHN1 SLC39A7 ZMPSTE24 ZFP41OPTN HLA-DRB4 C14orf39 DTX3LOR2A4 FLJ11292 SDE2 LTBP3OR2A7 NCK1 PDX1 LZTS1OR52N4 MLC1 GLTP FBXO5OR7E24 APOBEC3GCEACAM19 TMEM259OSBPL1A DEF8 NUMB ZNF830OSER1-AS1RP11-457I16.2MCM6 KLHL35OSGEPL1 SDHC RRM1 NFATC4OSMR GOLPH3 RP11-10K16.1 TPPPOTOA CPED1 CCDC112 TMEM109OTUB2 LOC100130741AHCY KCNK16OVOL1 QRICH1 NME1-NME2 /// NME2LIN54OXGR1 NDUFA1 KRT81 PRDM4P2RX3 CLASRP SH3RF2 PLXNB1

Page 76 of 781Diabetes

P2RY8 PTGIS R3HDM2 GLB1P4HB PPCS CCDC66 RTF2P4HTM HHAT DGKZ RFLNBPAAF1 NUDT15 MTCH2 RUVBL2PABPC4 PNPLA3 PGAP2 NOTCH4PACS2 FOXO4 LRRC16A BLOC1S6PADI1 TACR1 SPATA5L1 ZFP64PADI2 CDKL2 SPPL2B PSMD9PADI3 ETV4 HIP1R SFXN1PAEP SCNN1B MFSD1 CNIH1PAFAH1B3 RPIA CD5 PPLPAIP2B KDM5C SLC4A7 CSRNP1PAK6 GPS2 MFHAS1 IRF9PALD1 NHLH1 NUFIP2 DESI2PALM3 FCRL2 ABCC10 STX6PALMD FPGS DDX50 CALUPAM16 CSAG2 /// CSAG3PRPS2 RNF4PANK1 MSL1 LIN54 NDUFC2PANX1 RP11-714L20.1CSE1L PCDHB13PAQR4 PRPF4 UBAC1 METTL2BPAQR7 ATRAID IL11RA RNASE1PAQR9 CUX2 DDX39A DNMT1PARD3 SOCS5 BAHD1 REREPARD6A HCRTR2 FBL MBNL3PARP10 FRMD8 BANK1 DYNLL1PARP12 PRO1596 GHET1 LDLRAD3PARP14 PLA2G5 CD207 WDR61PARP16 TEX40 PTPLB EMG1PARP2 PRPF8 DNAH1 DTNAPARP3 TXNDC9 LOC101929889 /// SPNARFGEF2PARP9 DHX30 ETHE1 GSTO1PATL1 CUEDC1 SPSB2 PCSK9PATL2 ZNF302 PPP2R5C GPR173PAX4 ALAS1 TIAL1 RIT1PBX3 EFNB3 NXF2 /// NXF2B PIGHPBXIP1 MUC16 PITHD1 MRPL46PCBD1 SEC22B MRFAP1 DSTYKPCBD2 FOXD4 /// FOXD4L1ZNF678 LOC100287036PCBP3 RRP7A /// RRP7BTNC SLC10A3PCDH12 TAL1 NEGR1-IT1 PDLIM5PCED1B GNL1 INTS8 TMSB15BPCMT1 POLR2A MCM3AP-AS1 COL27A1PCP4 SMN1 /// SMN2RYR1 B3GALT4PCP4L1 MARK4 NR2F1-AS1 SCNM1PCSK9 C2 COX7A2L CAPN1PCYOX1L C3orf14 TAF1C PHF12PCYT1A DDN NACC1 MYD88PDCD1 CDKN1B EPS8L3 SARSPDCD1LG2UTP18 GPR113 MEF2CPDCD2 KIAA0907 ACTR8 SEC31A

Page 77 of 781 Diabetes

PDCD4 TRIM25 TMEM161B-AS1 LRRTM3PDE1A RHOH TRIM4 FBP1PDE4C RCOR1 VIPR1 PHF21APDE7B KIR2DL5A HNRNPH2 /// RPL36A-HNRNPH2SLC35B3PDF PDCD11 RBM15 SALL4PDGFC SBNO1 CTBP2 TBC1D8PDGFD LIPC C6orf47 NUDT7PDGFRA CD19 TSNAXIP1 OSBPL9PDIA2 PROZ HIF3A LYRM4PDIA3 TRMT112 GMFB TRA2BPDIA4 FAM182A /// FAM182B /// FAM27B /// FAM27CRP11-348N5.7 ARFGAP3PDIA6 ICA1 ODF2L CACNB3PDLIM2 STAG3 SNX9 PARVBPDLIM3 VWA9 ADIPOQ NEK11PDPN MAST1 RP11-468E2.5 TENT5BPDSS2 SNX17 PRDM7 SREBF1PDXK SCN5A TBCB XAB2PDZD3 LY9 CROCCP3 SLC6A16PDZD7 ESR2 NFKBIE COL1A1PDZK1 MRPS35 VPS37C MTF1PEBP1 PEMT GPR110 TNK2-AS1PECR MAP4K5 PLA2G6 TRIM14PEG10 SLC39A2 LOC727820 TIMELESSPELP1 IL18BP FGFBP1 RGNPEPD SMC6 PLXNA3 LTO1PFDN1 RPL8 THG1L MRAP2PFDN4 MRPL35 CHL1 RNF130PFDN5 VNN3 INTS12 DECR2PFKFB2 RRP15 LENG8 SLC4A11PFKP ADAMTS2 C3orf70 C9orf152PFN2 POLR2C FAM138A /// FAM138B /// FAM138C /// FAM138D /// FAM138E /// FAM138FEDF1PGAM1 CDK6 SLITRK6 PIGAPGAM4 TRPV4 FAM188B /// INMT-FAM188BVPS26CPGAP2 GCM1 ZNF469 PNPT1PGBD5 NDUFA8 LOC101930150 /// NF1MRPS2PGK1 HSF4 GPR133 CCDC85BPGM2 LAPTM4A TMEM208 CREBRFPGR PRMT3 PTGIR SOX18PGRMC1 ABI1 SPAG5 CEBPGPHACTR3 MAP2K1 KRTAP2-3 /// KRTAP2-4LRRC27PHB2 VAMP1 EIF2A VCPKMTPHF11 ABAT TTC9 MAK16PHF15 PCDHGA10SPRR2B PROSER1PHF2 CGB1 /// LHBPC ADCY3PHF7 PCDH9 LINC00969 /// SDHAP1 /// SDHAP2PTPN4PHGR1 GJA4 MRPL52 SEZ6LPHLDA2 ABHD10 TPM4 CYB5D2PHLDA3 NIPA2 PHLDB2 EEF2PHLDB3 FBXO28 HDAC11 KIAA1549LPHOX2A SFTPB AL832163 TMEM132A

Page 78 of 781Diabetes

PHYH PIK3CA PPP1R16B ZKSCAN5PI3 RPL36AL MRPL11 MYO19PID1 CHRNA4 SLC35A2 GCATPIEZO2 PIGC RP13-39P12.3 KIAA1211PIGB CER1 EIF3K OXGR1PIGK ADCY3 ATF7IP2 SEMA4FPIGP APOLD1 /// DDX47GAS8 KIF16BPIGR IMMT ADRM1 ZNF410PIGZ NR2E1 KLRC1 /// KLRC2 TPPP3PIK3AP1 SYT13 RFWD3 CETN2PILRA TSC22D4 GABRB1 DCAF16PIM2 INTS8 MYO9A USP13PIM3 ROBO1 SCAF4 RNF121PINK1 MYOZ1 OS9 ST6GALNAC6PIPOX CAV3 NF1 FAM185BPPITPNB CALML5 SUPT4H1 HMGB2PKD1L1 MYCT1 DSTNP2 TADA2BPKDCC GSDMD TMEM92 GRAPPKDREJ MORF4L2 AX746755 /// RP11-774O3.3KCNK3PKHD1 ACVR1 MYF6 FAM20CPKMYT1 OSBPL11 DSERG1 PCID2PKN1 CEP350 PLEKHB1 DDB2PLA1A CLIC5 CBR1 G6PC2PLA2G15 SDK2 AMIGO3 /// GMPPB CBX8PLA2G2D BLMH ULK3 TENT5CPLA2G4C EIF2AK3 NAP1L1 SLC8A1PLA2G4D AKTIP LINC00327 P2RY8PLA2G4E FES KSR2 NAXEPLAU EDA NSUN5 GRIN2APLAUR ZNF710 KCTD19 TMEM161BPLB1 DCAF6 WDR13 DOCK10PLCD1 ROCK2 GOLGA8N RTN4RL1PLCE1 CACNA1E CYP2D6 CKS2PLCH1 CA7 CCDC6 RFX5PLCL1 POU3F3 GPBP1 NUP98PLCXD2 CLDN11 ZNF252P CMTM7PLCXD3 SPO11 UBE2Q2L TMEM53PLD2 GLRA1 NOLC1 PRRC2BPLD6 SSR4 NBPF10 /// NBPF14 /// NBPF26TOMM6PLEK HDAC11 CTD-2310F14.1 MRPL38PLEKHB1 C1orf27 PPOX NRBP2PLEKHD1 SHOX2 TRIM32 CTNNAL1PLEKHG3 H2AFV CD2 EDN3PLEKHJ1 AXL TCEA1 RBAKPLIN4 ATP6AP1 SUMO3 CARMIL1PLLP TSPAN32 EPT1 KDM4CPLRG1 COX7A2L ATAD1 POLA2PLSCR1 RAD54L2 DCBLD2 RBP1PLXDC1 KCTD7 /// RABGEF1COX15 ZNF790-AS1PLXDC2 FOSL2 PNPLA4 TBL1XR1

Page 79 of 781 Diabetes

PLXND1 GINS4 NEK9 FGGPMAIP1 ARMCX4 NOL7 RAB3GAP2PML SPTAN1 KLHL9 B4GALT7PMS1 RNF5 GRPEL2 HIRAPMVK GUCY1B3 DNAJC7 CTHPNKD ACTR10 FAXDC2 SMIM30PNLIPRP1 TMEM47 BMS1P5 PLBD1PNMA3 PAOX SLAMF1 DNHD1PNMA6A BTN1A1 SYNPR PMPCBPNMA6B SLAMF8 TNXA /// TNXB CIAO2BPNMA6C RAB21 CROCCP2 ZNF740PNMAL2 YY1AP1 SYNGR4 MINAR1PNPLA7 CIAPIN1 TAS2R45 DCAF7PNPT1 KRT1 ZBTB21 DAPK1PNRC1 ADCY8 RS1 RXRBPODXL2 MYO5C SLC52A2 POGKPOLDIP2 RAB22A WASF2 DGUOK-AS1POLR1C AQR RNF7 EIF1BPOLR1E RPA1 TICAM1 MAMDC2POLR2E DNAJB6 /// TMEM135MAPK9 SNUPNPOLR3H CRYM SERINC2 ERGIC2POLR3K PPIL6 ZDHHC3 KCNE3POMP RPL3L SAMD11 WRAP73POMT1 HAP1 BROX COL3A1POU2F2 FCGBP SOX11 SEPTIN11POU3F1 FBXO21 LOC101928045 TESCPPA1 ICAM4 NEFL AK7PPA2 ANKRD1 EIF1AX AIDAPPAN PRPH PAN2 CCDC66PPAP2B PPWD1 MAGI1 PDK1PPAP2C MAPK8IP2 GEMIN7 CRTC2PPARG TCERG1 LOC102723678 /// LOC102723709UNC50PPCDC SDF2L1 C7orf49 SLC39A9PPID HCG18 LIMS1 PRXL2BPPM1M PIK3C2A PPARA SLC25A26PPP1R11 LPAR1 CCT6A UNGPPP1R14A ALPP STK17A LYRM9PPP1R16B TNFRSF25 LOC100996747 /// LOC101929876 /// RPS26 /// RPS26P11PPP1R3BPPP1R18 MLH3 IDH3G ECM1PPP1R1B ERF RBM39 PRPSAP2PPP1R1C SPHK2 BMPR2 MRPL17PPP1R3F ECE1 ARHGEF40 PIK3C3PPP2R1B HERC2P3 /// LOC101930458LDLRAD3 TSTD3PPP2R3B FEM1C PPAPDC3 MYH10PPP2R5B ZSCAN18 COX5B CWC22PRADC1 NUDT3 FUK TTNPRCP PURA SPATA16 VGFPRDM8 SIRT2 SRP9 UCHL3PREX1 SUZ12 CAPN2 FRG1PRF1 ICAM5 ARPC2 SLC35C1

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PRKAR1B DENND5A ZNF528 MEF2DPRKCH VPREB3 TSC2 GDNFPRKD2 TTC17 RAB26 SCCPDHPRMT3 LPAL2 PROSER2 MAP4K5PRMT7 KIDINS220 ENPP4 PDGFRBPROC AR HMGN3-AS1 COL18A1PROM1 DOCK6 KLHL5 SLC41A2PROM2 NUP107 RP1-179N16.6 LAMTOR4PRPSAP1 SLIT3 LINC00152 /// LOC101930489 /// MIR4435-1HGST18PRR15L SCARB1 PROSC SLC27A3PRR5-ARHGAP8PGM3 EGLN1 SUGT1PRRC2C LARS2 LOC101927268 /// LOC102724851SLC9A3R2PRRG4 KCNG1 KPTN CA13PRRT1 TROAP CYP4F11 GLIS2PRRT2 NLRP1 CDH6 PASKPRRT4 IFT122 TMEM116 LRRC10BPRRX1 CSF2 HMGA1 KIAA0319PRSS1 FAR2 RGL2 WDTC1PRSS23 PNRC2 PINX1 EVA1APRSS3 SULT1B1 DNM1P46 TMEM54PRSS46 HBP1 KIAA0895L KDM2APRTFDC1 SYTL2 LOC100132057 ZNF16PRTN3 SH3BGRL PTPRH C4orf19PRX TDG MALL PPFIA1PSD RAC2 FCGR3B WDR18PSG3 NKX2-5 ZSWIM8 TKFCPSG5 CLTC ZBTB16 GSTM3PSG8 ROR2 LZTR1 NTPCRPSG9 COX6C LOC101928861 PPP1R3CPSMA2 FURIN KDM1B COL6A3PSMA3 PVRL3 ZNF185 SOX6PSMA4 DNAJC6 ACSL6 ATXN7L1PSMA6 POU3F4 FAM192A CFAP61PSMB10 ASAP1-IT1 FMO2 IAPPPSMB2 SNX10 CRB3 AP3S2PSMB8 CDH15 ZNF703 EEF1AKMT2PSMB9 IGSF9B GNRHR DPH1PSMD11 KIF17 AKR1C2 /// LOC101930400TSPAN17PSMD12 SV2C LOC57399 TFIP11PSME1 IL17B PIGN FAM102APSME2 ARMC1 ZNF124 PKD1P3-NPIPA1PSMG3 GPX3 CHKA CXXC4PSTPIP2 CTSB FBXW7 SLC11A2PTAFR ASCC3 LINC01126 PPP2CAPTCH2 POP4 RNF121 PHETA1PTDSS1 MDFI AK023627 /// TCTE3 ZNF646PTF1A PDE10A SFTPD NAB1PTGDR2 UFSP2 SMAGP CARD11PTGER2 QPCT SIGLEC17P INTS1PTGES SON FAM101B CTDNEP1

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PTGR1 APTX RANGRF UBE2ZPTOV1 CNN3P1 /// CNN3P1KLHL23 /// PHOSPHO2 /// PHOSPHO2-KLHL23PSMD7PTP4A2 TSPY13P /// TSPY13PWDFY4 ZNF853PTPDC1 TRPM6 LOC285847 TMEM214PTPN1 PRSS22 LOC101927588 SLC2A6PTPRU RGS4 RRN3 ANKRD39PTRHD1 CDK5RAP2 DDT /// DDTL TSPAN3PVRL2 MATK ANLN GSK3APVT1 B3GAT1 LOC102725188 /// LOC727820SLC40A1PWWP2B MRM1 LOC100507283 WSCD2PXMP2 STAT2 RP11-1275H24.2 RIC8APXMP4 ERVH-6 TAF1D PWWP3APYCR1 THUMPD2 LINC01268 GGCXPYDC1 CDC7 AC083843.1 RASL12QDPR PRLH HNRNPU-AS1 SMIM15QPRT SNORA29 /// TCP1NCOA3 B3GNT2R3HDM4 SEPT9 HHLA2 SFXN4RAB11FIP3 SORBS3 PCDHB7 TP53INP2RAB17 LOC102724985 /// PDXDC1TTC25 KCNA3RAB19 TNFSF8 TNK2 RALGAPBRAB20 ATP6V1H LINC01138 WDR48RAB22A PHTF2 PRPF3 GANABRAB24 AC002310.7 /// ZNF785HNRNPLL KIFC3RAB2B BRINP1 LOC155060 PCDHB5RAB33A FAM182B /// FAM27B /// FAM27CTMEM50A APOL4RAB37 DEK ZFP91 MPNDRAB3A ITIH2 POFUT1 SCARB2RAB3IL1 PCF11 C1orf228 AKAP9RAB4A MGC40069 /// TRAC /// TRAJ17 /// TRAV20 /// TRDV2 /// YME1L1DCAF4 SMIM19RAC3 RECQL5 BRE-AS1 PUS3RAD21L1 ALDH18A1 WBP11 PRR14RAD51C PEPD MED12 BCL6RAI1 ERBB2IP ATP6 SPICE1RALB CD7 GUSBP1 /// GUSBP4 /// LOC100996497ANKRD6RALGAPA1RPS12 GPX4 C11orf98RALYL NIT1 JOSD1 ZC3H4RAMP1 HIST1H3I TJAP1 EXOSC5RAMP2 EPB41L5 BC043227 SIDT1RAMP2-AS1ITGA7 WDR90 URI1RANBP1 ATP5G2 MMP1 PPP1R16ARANGAP1 PDX1 VIMP PLK3RANGRF NARS THEMIS IL13RA1RAP1GAP TOMM70ASTAP2 MAFFRARRES1 SOX4 CHD9 POLR3FRARRES3 AKAP2 /// PALM2-AKAP2HECTD4 ERN1RARS BBOX1 MMACHC GOLGA6L9RASD1 PCCB TNFSF11 DNAJC27RASD2 TAOK2 GOT1L1 GMCL1RASGEF1ATIMM23 /// TIMM23BRALB NAPARASGRF1 NAE1 WDR25 GRWD1

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RASIP1 RIMS1 CALCOCO1 TRIM11RASL10B CAMK1D SEPSECS-AS1 LINC01138RASL11A HAPLN2 DOC2A SLC29A4RASL11B SH2D4A KLHL6 PRSS12RASL12 EGFL7 FAM43A NME4RASSF9 STX18 METTL6 LRRN1RAX RAB30 CCSER2 SEC14L6RBBP8 TGFB3 LOC101927027 ZNF510RBBP8NL TRA /// TRAV16 /// TRAV16 /// YME1L1VPS4B GSTM4RBCK1 RAD51C LOC100288778 /// LOC101930154 /// MIR6859-1 /// MIR6859-2 /// WASH1 /// WASH2P /// WASH3P /// WASH7PTSPAN2RBFA GRTP1 PARVG PRG4RBM20 TICAM1 CAPN10-AS1 RFX6RBM38 KIAA0509 LRRC37A3 TERF2IPRBP1 PRDM4 COX1 IMPA2RBPMS2 FHL1 LOC102724362 FLNBRCAN3 WISP3 SNAPC2 FCER1GRCBTB2 CDC23 GGTA1P METTL4RCN1 TAF7 ZNF165 SHISAL1RCN2 GSAP MRPS18A ACTL6ARCOR2 RAD23B C21orf15 /// LINC00417MYNNRDH10 ALDH3B1 CDR2 /// LOC101060399NCK1RDH12 SCRIB CR936796 SSU72REEP2 PPAN /// PPAN-P2RY11RRN3P2 DCTN5REEP6 PTPRC IGFBP3 TMEM184CREG1A FXYD7 LOC101929378 GOLGA2P10REG1B TP73 PRDM5 B4GALNT1REG3G SEPHS1 MRPL19 ELAVL4RELA PNPLA6 AP3M1 LOC105376805RELB NR2C1 TMEM179 ANKZF1RELL1 UBE3C DPY30 LRRC41REPS2 PRORY ARL8B VPS35RERG CCT3 /// LOC101927137SNHG19 SEC24CRETSAT MYOZ3 PSMD6 MKKSRFC3 TMPRSS4 BCAS2 MAP9RFC4 PZP CD34 ASXL3RFFL SENP6 LOC100134445 SLC9A7RFTN2 ARHGEF38 OSR2 RAB33BRFX5 NDST4 BOC RNF213RGL2 PKD1P1 NDUFB5 ZNF212RGL3 ADAM22 P2RY2 EDEM1RGMA RB1CC1 C16orf72 F5RGS16 MAPK11 ISYNA1 MFN2RGS9BP FCN2 LOC101927746 LZTS2RHBDF2 TNK1 NFATC4 CFLARRHBDL1 NCDN MOB3B FAM222BRHCG ADNP2 FAM95A TSFMRHEBL1 COL9A2 SHC4 CTSCRHOBTB2 OVOL3 PDPR BRF2RHOD SPATS2L TFG C17orf97RIMBP3 SSX2 /// SSX2B /// SSX3ZMAT1 LRRC49

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RIMBP3B UPK1A ALG11 /// UTP14A /// UTP14CZNF24RIMBP3C DUOX1 SCML2 PCDHB14RIMKLB LINC00599 /// MIR124-1CNOT3 FMO5RINL BMI1 /// COMMD3-BMI1GSTA1 B4GALT3RIPK1 SMR3A SLC4A9 C2CD4BRIPK2 MRPL28 RHOD MCEERIPK3 UBE2N RP11-314N13.3 PBX1RIPPLY2 AVPR1B CCDC122 SMARCA5RLN2 ITGB1BP1 NUDC ZNF84RMI1 SEMA6A RP11-174G6.5 PDK4RMI2 TM2D1 LOC100506107 LOC107985246RND1 PLEKHG6 TMEM132C TOB1RND2 RNF4 DNAH3 CHMP4CRND3 BRD7 COLGALT2 C4orf47RNF114 CABP1 SIX2 IMPDH1RNF130 THNSL2 DDX5 ARID3BRNF144B KCNMB3 ZDHHC8 MVB12BRNF148 UHRF1BP1LPRODH2 PPM1KRNF149 C1orf95 GK3P SPDYE18RNF157 FOXB1 LOXL2 AKNARNF182 DUSP21 RP11-1109F11.3 MATN2RNF186 ZCCHC10 AC007401.2 CD200RNF19B EBAG9 MPP5 TMEM125RNF2 GPR144 HIST1H1B ZNF321PRNF208 CBX1 ARHGAP9 SCN9ARNF213 FAIM3 DCTN5 TMEM70RNF214 DENND1B SUCLG1 FOXN3RNF220 SERPINC1 LOC221814 CDC34RNF24 HSPE1-MOB4 /// MOB4C3orf43 ZKSCAN8RNF8 RP11-217B7.2PRIMPOL GRB14RNFT1 INSM1 PPP1R7 MAGOHBRNH1 PNPLA2 PRKCDBP MORC4RNLS KCNN3 VSIG4 STAM2RNPEP TUSC3 GOSR1 USP42ROBO2 NTNG1 ENTPD2 HMGB1ROGDI IFITM1 POP4 ANKRD34AROM1 HMGB2 VKORC1 ZNF7RORC NAA50 C1QA PPT1RP1-140K8.5HSF2 LOC100288778 /// LOC101930154 /// LOC102723897 /// MIR6859-1 /// MIR6859-2 /// WASH1 /// WASH2P /// WASH3P /// WASH7PUSPL1RP1-193H18.2CHD1 SNX20 GET3RP1-212P9.2JRK HNRNPC RAE1RP1-224A6.3NEK4 HTATIP2 LBHD1RP1-278O22.1TUBA8 MRPL37 GAPDHRP1-60O19.1GRAMD3 PRH1 /// PRH1-PRR4 /// PRR4SAC3D1RP11-1002K11.1SLC10A1 RP1-74M1.3 BLVRARP11-1055B8.3SULT1A2 MLLT1 BICD1RP11-109D9.4ACTR6 MARCH11 SMC5RP11-111M22.3ST8SIA2 LOC100507472 /// PCSK6PFDN2RP11-112L6.4ARID5B AK000798 ATXN2LRP11-1136L8.1IARS2 ADCY10P1 IFITM1

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RP11-113K21.4ACAN LOC441204 SNX10RP11-11N9.4SEC14L1 DCDC1 /// DCDC5 DNAAF2RP11-121C2.2CHIT1 SNHG22 PPIARP11-122K13.14CXCL13 CMTM1 GTPBP4RP11-1348G14.4CCDC30 KIAA0930 ACERP11-134N1.2SCNN1D SRSF5 ELOARP11-137H2.6NUP54 NPAS4 C1QCRP11-13B9.5HP1BP3 RP11-1109F11.5 ZRANB2RP11-13N13.2TMEM63A LAMA5 DDX55RP11-1406H17.1HIST1H4A SDAD1 ZNF343RP11-140M13.1AOC2 SYN2 MAPK3RP11-143K11.1FAIM MIS18A RAB24RP11-157E21.1HSD11B2 GMEB1 ME3RP11-162G9.1PHACTR2 CRLS1 BLOC1S1RP11-16E12.1KCNE2 CDC123 LDHARP11-184M15.1COMMD8 KRT19P2 TMED9RP11-204M4.2FCN1 TMEM198B SPATA3-AS1RP11-206L10.9MIR6716 /// PHLDB1MIR22 /// MIR22HG LAMA4RP11-211G3.2SPATA31A1 /// SPATA31A3 /// SPATA31A5 /// SPATA31A6 /// SPATA31A7C6orf120 PTPN23RP11-211N8.2OR1D5 SLC22A9 EIF3HRP11-213H15.1DISC1 C14orf142 SIGMAR1RP11-214N9.1OR10H2 IL23A /// TCRBV6S2A1N1TMCRIP1RP11-223C24.1ESPL1 PTGES3L PDSS2RP11-258C19.7ONECUT2 TMEM241 ENTPD4RP11-259O2.3DEFA4 LOC102724880 RASL10BRP11-25J23.3KCNJ12 /// KCNJ18 /// LOC100996843LINC00276 TSSK3RP11-276E17.2FAM20B CYP46A1 NAGARP11-277L2.3PAPSS2 GCGR TOP2ARP11-277L2.4DHX16 EID2 IPO13RP11-279F6.1DAP3 GLIS3 PARP8RP11-27N21.3MUC7 EEF1B2 /// SNORA41 FLJ37453RP11-284F21.9TRBV5-2 /// TRBV5-2ALPP UBP1RP11-285A1.1CFH RRP9 HSPD1RP11-288G11.3ARID4A STON1 YIPF6RP11-288L9.1ANAPC2 USE1 NAT14RP11-292F9.1SFXN3 LOC101930608 /// LOC102723581CPNE4RP11-297M9.2HSD17B12 RNF5 /// RNF5P1 NEUROD1RP11-2E11.5TACR2 METTL7B TEKRP11-2L8.1RARS NADSYN1 PACSIN3RP11-31E13.2SYMPK DGCR11 CISD2RP11-320M2.1LRRC15 LARGE GSTA4RP11-320P7.2PAPOLA BAAT MFAP3RP11-322E11.5ANXA7 PTAR1 PTPRERP11-326I11.3ASS1 TSHB ARHGAP30RP11-327I22.8IGH /// IGHA1 /// IGHA2 /// IGHD /// IGHG1 /// IGHG2 /// IGHG3 /// IGHM /// IGHV4-31OPA1 SLC3A2RP11-337C18.8SLC26A1 PAFAH1B3 RHOBTB2RP11-340I6.8PCSK6 LIG1 PGAP3RP11-344B5.2CHP1 RIC3 NDUFAF2RP11-345M22.2DLG1 GADD45G SEPTIN7P2RP11-346C20.4RTCA OSBPL8 MFSD8

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RP11-353N4.4LSR TRIP11 DIP2CRP11-367F23.2LINC00474 SPHK1 OAS3RP11-375B1.3FRMD1 TBC1D8 MRPL18RP11-37B2.1PRSS53 LUZP1 TUBA3FPRP11-383C5.3ADCY6 CLTC PIK3C2BRP11-383C5.4MAP3K3 RBCK1 TBCKRP11-384P7.7C6orf47 PAXBP1 TMEM51RP11-38P22.2GJD2 GNB3 CC2D2ARP11-390F4.6MYO16 CSTF3 DENND2ARP11-391M1.4USP2 CORO1C KCNK6RP11-394I13.1CCL21 NR2F2-AS1 AHI1RP11-3P17.4GDF3 DNAJA1 CPEB3RP11-403I13.8FAM47E /// FAM47E-STBD1 /// STBD1LOC100287221 CCDC69RP11-407B7.1NEK3 EIF4E2 HECW2RP11-408H1.3KCNJ3 BAMBI JTBRP11-410L14.2SMG6 AKR1C1 INSIG2RP11-419C23.1ARF1 /// MIR3620S100A14 IFIT3RP11-426C22.4SNRK SPTLC2 MOB3ARP11-42I10.1ARFIP1 DDX11 /// DDX12P /// LOC642846KIZRP11-430C7.5SLC25A46 LYPD6 CACHD1RP11-439L18.1ANKRD53 ASNA1 BTBD2RP11-43F13.4OTOF PPP1R15B ZNF264RP11-449D8.1PPP2R1B LOC100506282 BAZ2ARP11-44F14.2APOL5 KIAA0556 BCLAF1RP11-44N21.1THAP3 MIEF1 ATG16L1RP11-457M11.5BAI1 ZDHHC21 AMZ2RP11-459C13.1FABP5 GPR3 TMC3-AS1RP11-462L8.1AMBN TMEFF2 DNAJB4RP11-463O12.3DHX40 ABHD11 OSER1-DTRP11-468H14.2POLD4 CLDN14 SF3B6RP11-473M20.16TRIM44 COQ10B SMCR8RP11-475I24.3HTT IDI1 PDPK1RP11-490M8.1LOC100506571LOC100505664 TRAM1RP11-491F9.5CD8A FLRT3 NMT1RP11-497E19.1NOC4L HYKK ANO10RP11-498P14.5SLC28A1 MCU USP15RP11-502I4.3PTPRCAP ADAMTS2 CDK16RP11-504P24.4KRT10 HIST1H1A NME6RP11-512M8.5ACBD4 COX14 PMS2CLRP11-527D7.1LOC102725072 /// LOC102725315 /// LOC727983 /// POM121L10P /// POM121L1P /// POM121L4P /// POM121L8P /// POM121L9PLOC101930059 /// LOC102724250 /// NBPF1 /// NBPF11 /// NBPF15DDX1RP11-532F6.3ACBD3 NECAP2 UBXN7RP11-546K22.1CD2BP2 SLC27A1 EIF2B4RP11-557L19.1CAPZA1 ANXA2P2 MEPCERP11-560J1.2KLRC4-KLRK1 /// KLRK1HLA-DQA1 /// HLA-DQA2 /// LOC100509457ITPK1RP11-561O23.5SUPT16H VASH1 UPF3BRP11-566E18.3APOBR ADCY9 ITGB7RP11-567M16.1EXOC2 GJB3 PCDHGA6RP11-572C21.1UBE2E1 MAGI2-AS2 ARHGAP10RP11-61A14.2ASNA1 HHEX BMPR1ARP11-61J19.4MXRA8 DCPS THOP1

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RP11-626K17.3POLM ITFG1 MPP6RP11-638I2.6NPPA CMYA5 LTBP2RP11-69I8.2STAP1 LOC101930075 /// PKD1SLC25A35RP11-6F2.5NUDT21 HDX ZNF329RP11-701H24.2VPS54 PHF6 ZDHHC6RP11-701P16.5GOLGA2P7 /// LOC101929479 /// LOC642423 /// LOC727751 /// LOC80154VAC14 C5orf22RP11-709B3.2TOB2 CDC6 U2AF1L4RP11-798G7.6KIF25-AS1 RP11-454F8.2 ID2RP11-79H23.3ENO3 GPLD1 ZC3H15RP11-7O14.1PLSCR2 OASL ULK1RP11-806H10.4IL7R RAI14 SYT16RP11-819C21.1SRPK3 KRT23 NELFCDRP11-81A22.5FMR1 NXF1 ATP13A1RP11-838N2.4MRPS28 KB-431C1.5 RB1CC1RP11-849F2.9KCNA2 CDC42EP2 DAPL1RP11-84C13.2ATP5F1 FOPNL POLR3HRP11-862G15.2MVB12B BC037214 /// RP11-58G13.1TMEM182RP11-883G14.1NEK1 MMP19 COL13A1RP11-91K9.1SLC1A6 ANKAR TAF12RP11-923I11.1DUX1 CARKD NAGLURP11-923I11.4SGCD CCDC43 NUDT3RP11-93L9.1CHRM2 RNGTT BORCS6RP11-95P2.1PSORS1C2 RP11-33O4.1 QRSL1RP11-97O12.2INA LOC728073 EPHX1RP2 PDGFRL KIAA1614-AS1 IMMP2LRP3-468B3.3RABAC1 MAPKAPK5 PHLDB3RP4-594I10.3CLCA1 C2orf68 CTTNBP2RP4-737E23.2SPAG9 SEMA6C FAM91A1RP4-794H19.1PQLC2 PCDHB15 PLAARP4-794H19.4AOC4P MAP2K1 COBLRP4-809F18.1HIST1H3G RP4-740C4.7 KIAA1143RP5-1021I20.2TRAK2 RAB3B CAPZBRP5-1086K13.1SAG TAF5L GPS2RP6-206I17.3ETFDH GCKR ZNF404RP6-74O6.2KLK8 UPP1 LOC729218RP9 CAPN10 LOC647070 PLD2RPA1 GATAD1 AK311120 /// LSAMP SH3GLB1RPAIN PSMC4 TMEM141 CHRNERPGRIP1L CPB2 KIAA2018 RIPK1RPL10A P2RX6 C19orf70 NUP88RPL11 MOSPD3 CHPT1 GPR89BRPL12 RNF219 LOC101927907 GTF3C4RPL13A TG NUDT3 /// RPS10-NUDT3PELP1RPL15 UBXN2B KMT2B PUSL1RPL17 CHPF ACOT1 /// ACOT2 PTP4A2RPL18 SLC35A5 SDPR MREGRPL21 PROP1 G2E3 TNRRPL22 PPP4R1 TAF13 MYO10RPL23A RPH3A IGHG1 /// IGHG2 /// IGHM /// IGHV4-31 /// MIR8071-1 /// MIR8071-2UBE2E3RPL26 ETV7 DICER1-AS1 MIIP

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RPL26L1 NAA60 SLC35F5 C1orf115RPL27A KIAA1045 ING4 TLE5RPL3 TEFM MACROD2 ATP6V0E2RPL30 GNAT3 ZBTB48 DHRS7RPL31 ZC3H14 LOC100505874 SIX3RPL32 FOXC1 FRG1 /// FRG1B /// LOC100134091 /// LOC100289097 /// LOC101930278 /// LOC101930531 /// LOC102724923TGFB1RPL35 CSDC2 ZBTB11-AS1 OLFML1RPL35A MAPK9 FBXO31 PRDM1RPL36A ATAT1 FAM214A TLE1RPL37A SETX GET4 /// SUN1 CHST8RPL4 KIR2DL3 NUDT14 CYB5ARPL5 GSTM3 DKFZP761C1711 SLC25A36RPL6 MR1 VPS45 RAB21RPL7 DAB1 LINC00894 PLEKHB2RPL7A IQCB1 MCTP2 CDYL2RPL8 APMAP NCSTN EIF2AK1RPL9 PDS5A SERBP1 FAM161BRPLP0 DDX41 RP3-508I15.21 XIAPRPLP2 STX16 RP11-727A23.11 MUC13RPP30 ATXN2L ZNF557 AKAP7RPRD2 THSD4 RPL17 /// RPL17-C18orf32 /// SNORD58A /// SNORD58B /// SNORD58CYPEL5RPS10 AIM2 NPC1L1 NKAIN1RPS14 ATP6V1E1 MOCS3 RHOJRPS15A IGHD PRPF40B LSSRPS16 ADO C1QTNF3 SUOXRPS17 ZNF280B CLHC1 MRPS10RPS17L CLCC1 MAP2K4 YOD1RPS18 ZNF428 TIMM50 RAD23ARPS2 PEX5 NEO1 DFFBRPS23 TEX30 IL11 SIPA1L3RPS24 ZFAND6 LIF GPRIN1RPS3A PRAME MRPL3 SLC35A3RPS4X HAUS3 SETD7 NRP1RPS5 BRSK2 EVX1 PGRMC2RPS6 GABRG3 ATG2B MIR7-3HGRPS7 LAMTOR5 EMC6 GTPBP10RPS8 KLF12 RASA1 BTF3L4RPSA BMP8A CTD-2124B8.2 SETD3RPSAP58 ZKSCAN3 OSGEP IFT88RPUSD3 SLC35A1 STOML2 TM9SF3RRAGD LOC100289473AC092192.1 PKDCCRRAS AF007147 COA6 MRPS23RRM1 PCDHB17 S100A2 MRPS35RRP36 ZWINT LRRC58 MON1ARSAD1 PACS1 RP11-248J18.3 ZNHIT6RSAD2 TCL6 LOC100132352 LSG1RSPO3 ANK2 RHOT2 HSF1RTKN UBQLN4 MTCL1 FAM136ARTN3 NKG7 MOCOS ILF2RTN4RL1 IGH /// IGHA1 /// IGHD /// IGHG1 /// IGHG3 /// IGHM /// IGHV3-23 /// IGHV4-31VAC14-AS1 EHHADH

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RTP4 ADAP1 GPR173 ELAVL1RUFY4 PCDH11X /// PCDH11YLOC101930114 TOM1L2RUNX3 HMX1 KIAA1143 KBTBD6RWDD3 TSKS MBD2 HIST1H2BNRXRG PLAA ZNF518A SMIM10L1S100A14 BCAN MZF1 OLIG3S100A8 GCFC2 RP11-339A11.2 MPZL3S100A9 CKAP2 /// IGLJ3 /// IGLV3-19 /// IGLV3-19SGMS2 YEATS2S100B UCN CEP85L WDR3S1PR5 AC007389.3MRPL34 AIFM2SAA1 GNL3L TBC1D10C WDR4SAA2 MYH11 SLC25A27 SMIM13SAA4 CABYR PMS2L2 SDHAF4SAE1 ITGAM CENPU AEBP1SAMD13 HOXB7 MNX1 DECR1SAMD4A C1orf109 LINC00674 KLF10SAMD9 SUMO3 HYPK /// MIR1282 /// SERF2 /// SERF2-C15ORF63DOLPP1SAMHD1 MNAT1 GUSBP4 /// LOC100653061LMO3SAMM50 IHH CD6 CACNA2D2SARDH USP24 CD276 TDRKH-AS1SARM1 MAGED1 YWHAH CREG1SARS2 VAMP3 KLHDC1 GNAI3SAT1 PPIA RPS17 SMCHD1SAT2 USP25 MTFR1 NOP2SAYSD1 MFAP5 SLC25A40 SCAF1SBK1 ZC3H13 LAMA3 PKP4SBNO2 TTC27 TSPAN5 TRAM1L1SCARB1 NHLRC2 ANXA11 COL4A2SCARF2 RTEL1 /// RTEL1-TNFRSF6BRSL24D1 MEG3SCD5 THBS2 RBX1 ZNF532SCFD1 SLURP1 EXT1 TOMM34SCG2 IFT22 RAB27B MMP14SCG5 GPD1L UBXN7-AS1 C1QASCGN UQCRC2 RAB25 LXNSCML1 DLG5 RBM34 LINC00543SCML2 MAGI2 QTRT1 RRP1BSCO1 MTOR RPL5 /// SNORA66 /// SNORD21UBE2CP5SCO2 OR1G1 ABCA8 PMS2P4SCOC LRCH4 CSGALNACT1 FAM199XSCRG1 EFCC1 MRPS35 DACH2SCRN3 MMP11 AGBL3 ST3GAL6SCRT1 AGTPBP1 ATF1 PALMDSCTR NASP ERP44 GABPB1-AS1SCYL3 PKD2L2 RFNG STXBP6SDC1 GZMH ZMYM2 RETREG3SDC2 MMP19 TAX1BP1 KIF26BSDCBP2 RHOT2 USP48 ANKRD23SDHA SNCB PI3 LOC101929479SDPR SSR2 TUBGCP6 MLH3SEC11A TSSK2 S100PBP AARSD1

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SEC11C ICMT PARPBP PBLDSEC14L5 MMP24 FEZ2 SAP130SEC14L6 PSMC6 KRT80 TBCELSEC63 AKAP4 CDHR2 ZNF75ASECTM1 OARD1 LOC101929475 CDC7SELPLG ZNF444 SCARNA15 ARAP3SEMA4G EYA2 RND2 SCAPSEPHS2 ITPR2 MORN1 SSPNSEPP1 MAGEC2 SNX2 MPRIPSEPT1 SLC47A1 L3HYPDH WDR45SEPT3 KIF1B GPRC5A MCUR1SEPT4 CROCC LOC286437 CHROMRSEPT5 LOC102723620SNTG1 TASP1SEPW1 SOCS3 LOC100134317 /// LOC284412BTRCSERGEF ZNF226 NIPA2 DGCR8SERP2 PECR DMGDH PCDHGB3SERPINA10MAPK3 WASH1 /// WASH2P LRP3SERPINA4 WDR37 EIF3F HMGXB3SERPINA5 HS2ST1 CACNA1A /// LOC100507353HACE1SERPINA6 JTB INMT P3H1SERPINB1 ALPL PRPF18 KATNB1SERPINB7 UBE2K ERVK13-1 BRD8SERPINB8 RASL12 SBF2 DDX27SERPINB9 GHRH EFCAB4A RNF44SERPING1 NDUFA10 WBP2 KANK2SERTAD1 DUSP9 ENKD1 ALKBH2SERTAD3 SULT2A1 FDXACB1 PDFSERTM1 ATG9A COPS5 ZMYM5SFMBT2 AAK1 PSG11 /// PSG3 HOXB3SFRP5 HIPK2 VPS4A LRRTM4SFT2D2 ALDH3B2 SLC36A1 P3H4SFT2D3 BNC2 ZNF213-AS1 SDHAF2SFTA1P PSMA5 FZD8 /// MIR4683 CHUKSFTA2 TBC1D12 DLX2 IQCB1SFXN4 EPHA4 DQ597730 /// LRRC37A2SERINC3SGCD GPRASP1 RP11-506O24.2 AUTS2SGCG SAMM50 CYTIP TMEM216SGK2 FBXL14 ARG1 NFATC2SGMS1 EFCAB14 LOC283045 CCNYL1SGOL2 LOC102724364 /// SEC22BSLC25A3 ALDH4A1SGPP2 TSPAN12 RHEB API5SH2B1 RN7SKP150TAF1B RAB20SH2B3 ASIC4 ITGA7 TRAPPC6BSH2D3C NOS3 MET CNTROBSH3BGR APOL3 ATP5J SCINSH3D19 RWDD3 RDH5 RBM18SH3RF2 CRYZL1 HERC2 GALNT11SHB SLC35A3 C20orf26 SNRNP40SHBG RAP1B POTEM ADCYAP1SHE RBM17 TCEB2 MED4

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SHF DNAJA1P4 /// DNAJA1P4CDK3 /// TEN1-CDK3 TSPAN6SHISA5 MOBP LOC91548 AGTSHISA7 MYO1C RIMS1 DTX1SHMT2 FOXC2 RGS20 LINC00472SHROOM1 SNAPC2 GALT SRMSIDT1 CD40 CDC45 VPS39SIGLEC1 GATA2 CCDC127 ZNF302SIGLEC10 TCP10L TTLL3 MFNGSIGLEC11 LTB4R2 MTHFD1 RIN3SIGLEC7 LOC100506504SLC7A11 PKD1P1SIGLEC9 TRPC3 ZNF593 LARSSIGMAR1 IFNA21 ELMOD3 HSPBP1SIPA1L1 LRRC59 PTGS2 THEM6SIRT5 SLC11A2 CCDC78 FKBP3SKA1 TMEM14A NFX1 SETXSLA2 PPP1R2 HSF4 TMBIM1SLAMF1 GGCT NKIRAS2 NPM3SLAMF7 SGCG MAG HDHD3SLAMF8 GLCE RAB6A /// RAB6C /// WTH3DINMBSLC11A2 CD200 SNAPC3 CNIH2SLC12A7 LOC101929597 /// TBCDKIF19 TTYH2SLC13A5 RNF11 DYNC1I2 PDP2SLC15A3 ACVRL1 IKZF1 DPP3SLC16A11 PRKCB KCNH6 PPP2R5DSLC16A3 CLPX ITGB6 /// LOC100505984NPLSLC16A9 ECEL1 FBLN1 PIANPSLC17A4 PPP1R8 ND6 MTSS1SLC17A5 FA2H MSH6 C10orf88SLC18B1 RGS14 GAGE1 DIAPH2SLC1A1 ERO1L MIR622 PLEKHH1SLC20A2 EPB41L4A CLRN3 RNH1SLC22A3 SSH3 EPOR /// RGL3 ICE1SLC22A4 WSCD2 GTF2F2 CSNK2A2SLC23A2 GPI LMAN2 BCORSLC24A1 RBL2 ITGB3 C11orf71SLC25A11 ZNF277 IL1R2 TARSSLC25A15 DOCK9 AK3 PHC2SLC25A19 FGF21 PEX12 TMEM273SLC25A21 UBTD1 HNRNPU TRIM52SLC25A22 SCPEP1 ZBTB2 DND1SLC25A23 PCDHA10 DNM2 APBB1SLC25A28 TRIP4 ABCA7 TSC22D1-AS1SLC25A29 BCAM TMEM189 /// TMEM189-UBE2V1 /// UBE2V1MARSSLC25A3 TCRBV12S3P2RY1 GOT2SLC25A34 YME1L1 GATAD2A PIK3R3SLC25A35 TPM2 TGOLN2 TNFSF13SLC25A39 ITM2B LEP SCO2SLC25A42 RAF1 ZFAND2A GOPCSLC25A51 ASGR1 HSPA12A TAF1ASLC25A6 SPSB1 MOB1A C1QTNF6

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SLC26A2 CHCHD3 PPCDC OLFML2ASLC26A4 IMPAD1 RPL19 GOLGA7SLC27A3 JMJD1C MYADM FAPSLC27A4 LUZP1 FDX1 SPP1SLC27A5 TNFSF9 A2M MED6SLC28A3 CHRNA6 PDCD2 PFKMSLC29A1 SH2D3C IFT172 ADAT2SLC29A2 ITGA8 RANGAP1 STAT2SLC29A3 DNAJB14 EHMT1 CASC2SLC29A4 IGHG1 /// IGHG2 /// IGHM /// IGHV4-31 /// MIR8071-1 /// MIR8071-2MAP3K12 ESR1SLC2A5 ALPI TIPIN CCN4SLC2A6 IBA57 SYNM ADPRMSLC30A5 SH3GL2 MAB21L1 /// MIR548F5CHRAC1SLC30A7 BTNL3 NUP93 ABHD15SLC30A8 LINC01278 ARRDC2 ESAMSLC31A2 MTFR1 LSM8 HAUS3SLC34A2 MYBPH RND1 NFKBIBSLC35B2 RUNX2 CPNE1 PLXNB3SLC35D1 LSP1 SND1-IT1 DHX8SLC35D3 RPS6KA3 FAM57A TRAPPC11SLC35F1 SSBP3 PAM PER3SLC35G1 NPTXR FLJ45513 /// TAC4 LARGE1SLC37A1 PSG9 UGDH C1GALT1C1SLC38A11 C5AR2 GTPBP4 PRDM16-DTSLC38A6 GALNT4 /// POC1B-GALNT4MARK1 ZBED1SLC39A10 LYL1 TMEM14B CDT1SLC39A14 LUZP4 POMT2 MGAM2SLC39A2 MRPL34 CHMP1B CHD5SLC39A5 TOMM22 TP53BP2 NGRNSLC3A1 SCARB2 RPS19BP1 KLHL28SLC41A3 GABRQ ACKR1 TIMP1SLC43A3 PADI2 TMEM120B DNAJC11SLC44A2 NDUFB5 KCP PSME4SLC44A3 STAB2 PIGG UBA2SLC45A1 RPS14 USP20 SUPT4H1SLC45A3 NUP50 RELT HOTSSLC48A1 NKAIN1 DHCR24 PTGER4SLC4A3 MAGEB4 VAMP8 SEC23ASLC4A4 TRMT61B AJ420595 /// GOPC ZBTB46SLC5A10 ROCK1 IGFBP7 BNIP2SLC5A5 ADK IL2RG FBXO38SLC6A14 RPGRIP1 ZNF550 CDK2AP1SLC6A20 CEP170B GCFC2 FOXJ2SLC7A14 EHBP1 CPT1C C1QTNF5SLC7A5 GGTLC2 ASRGL1 TUBA1BSLC7A8 ODF1 DQ576994 ZBTB49SLC9A8 H2AFZ RP11-498E2.7 GYG2SLCO4A1 NFIL3 RPL27A /// SNORA45ACKMT1BSLCO4C1 GJB4 CST6 PCSK1SLFN5 SPTLC1 DDX10 GASK1B

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SLITRK5 F7 NKTR PPP1R1ASLITRK6 SPATA2L PUS7 FDX1SLMO1 DLX6 DAB2 SPON2SMAD3 INSRR SNRNP200 CDV3SMARCA2 PTBP2 LRRIQ1 DNAJB2SMARCD2 POLR3K PSMG2 GPR137BSMIM1 RAP2C TAB2 NOC2LSMIM10 NHLH2 MIR6513 /// TMBIM1 IFRD2SMIM11 RAB3A BRD8 GBGT1SMIM18 RBM41 LRRFIP2 MOV10SMIM4 HRG PARP4 RABL3SMIM8 SLPI ZNF277 YIPF3SMOX CHRNA1 TMEM145 SLC25A34SMTNL1 SNRNP70 TMEM18 CLSTN3SMURF1 RHBDL1 KIF1C ZNF672SNCAIP CPN2 ATP5B LOC101929550SNCB MIR6787 /// SLC16A3KRT19 MRPS31P5SNCG SORBS1 ZNF264 KIAA1614SNHG1 CYP4F2 BC041347 /// FLNB-AS1 /// FLNB-AS1LUZP1SNHG6 DHRS2 WDR16 SPTAN1SNHG9 TERF2IP CLCA4 TSTD2SNPH ARF5 FBXO15 LYZSNRNP25 LINC00652 LOC101926913 ENPP5SNRNP48 ATP8B3 C2orf27A CLINT1SNTA1 RASGRP2 SBF1 TNKSSNTG2 CNTN2 CHDC2 LINC01106SNUPN PRMT1 L3MBTL1 RNF7SNX10 TMEM151BKRT6B NET1SNX2 CAMSAP2 LINC01013 SNAPC4SNX20 CGRRF1 PCGF1 NUP43SNX21 SYNDIG1 GALE AMACRSNX30 TRIM26 KLHL18 TRIM23SNX5 CRABP2 FAM175A RDH12SNX6 RSAD1 SLC25A43 AGTRAPSNX7 XPNPEP2 ZW10 HHATLSOAT2 GUCA2B RNF139 COL5A1SOCS1 ACAD10 FIBP REEP1SOCS3 HSPD1 PTHLH MROH1SOD2 TCN2 C3orf67 FLCNSOGA1 SOX17 ATOX1 MAP3K11SORL1 EPS8L2 FOXE1 CACNA1ASORT1 WDR76 ATAT1 ZBED6CLSOX18 MEPE ADPRHL2 CTPS2SOX3 TNKS TMEM120A ZSCAN25SOX7 CSRP3 MYH9 CNRIP1SP100 FOXA2 COPS8 DLATSP110 GNA15 MTHFSD NAF1SP140L DSCAM APOM SEC23BSP6 PSENEN AP2S1 IPO5P1SPAG16 PALB2 DNAH7 C17orf100

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SPATA16 GCH1 OR7E47P KMOSPATA21 WRNIP1 HSH2D RSPH1SPATA7 MLLT11 LOC101929757 PCDHB16SPC25 BZW2 LRIG2 CD40SPDL1 MLX LOC100289230 BMS1P20SPDYA DRG1 USP5 DUS3LSPEN SPTBN5 ARL9 AOPEPSPG7 BCL2L14 LOC646214 CCDC88ASPNS3 ABCC8 LST1 CHD7SPPL2A CDK8 BAIAP3 SRSF10SPR CD5L WARS CD81SPRR2A GYG1 E2F7 ADD3SPRR2D FOXN3 FUT4 KLHDC8BSPSB4 LSM7 LINC01207 HMGN3SPTLC3 TMEM230 GAN CDK12SPTSSA LHX3 ABCC4 NBL1SPTSSB TMEM41B RPARP-AS1 TAF1SQRDL CASC3 /// MIR6866BAALCOS TLN2SRCRB4D PARP12 MITD1 TBC1D2BSRD5A1 MRPS10 CYMP MAP7D1SRGN CERK LOC221272 RANBP2SRP9 FARS2 DBF4 SF3B5SRPX MARCO RECQL JMJD4SSR2 PTPRS RP11-95O2.1 LSM12SSSCA1 RHCG C14orf1 AGPAT5SSTR2 ATP5C1 HIST1H2BJ LCP2SSTR3 UNC5B NFKBIB PMS2P3SSTR4 COPS4 GVINP1 ZSWIM8ST14 EPHB4 FLNB SLC25A22ST3GAL2 PI15 GRIK2 DHCR24ST3GAL5 SNHG3 /// SNORA73AMIR4691 /// MIR7113 /// NDUFS8NAP1L4ST5 C17orf75 FANCG IGFBP7ST6GAL2 SCNN1G SH3TC1 CHMP5ST6GALNAC6CYP11B2 GSKIP CASTST7 EIF2AK2 TMEM144 TMEM44ST8SIA3 IL4 UBAP1 MRPS22STAP2 PDE1B KNTC1 CLCN3STARD4 RFXAP ASPDH PLOD2STARD5 ABCD1P2 /// ABCD1P2DDB1 MATN1-AS1STAT1 ARPC4 /// ARPC4-TTLL3 /// TTLL3GCSH /// LOC101060817EXOSC9STAT2 CD302 /// LY75 /// LY75-CD302KAT2A FAM102BSTAT5A SLN THAP1 ING4STAU1 ID3 AX747652 SYNJ1STEAP4 PCK2 PTPRCAP KTI12STIL CACYBP HABP4 MYADMSTIM2 GALNT12 HS3ST1 BGNSTK16 ADRB3 SSNA1 GALK2STK32A ALOX12P2 RP11-158G18.1 SOX5STK32B PIGG LOC102723954 PIGLSTK32C CYB5R4 CD68 /// LOC101928634 /// SNORA67AZI2

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STK33 TMEM180 S100A6 ARFGEF1STMN1 NSD1 FRMD5 ASB4STOML2 SHARPIN SLC35A1 CHMP2BSTON1 DCHS2 RP4-781K5.2 VANGL2STRBP COL7A1 LECT1 PECAM1STS KIF21B UCA1 AK2STUB1 RANBP9 KLF5 LY75STX10 NXPH4 PSMB10 ARHGEF10LSTX11 S100PBP KDM4C BTCSTXBP1 MRPL2 PRSS30P TBKBP1STYK1 CFHR5 COL14A1 DUSP4SUGP2 SEMA6B STAU1 BBS2SULT1A1 CACNG5 RBM19 APOL2SULT1B1 ATXN10 LOC150776 /// SMPD4UNQ6494SUMF1 RNF115 WDR86-AS1 ALG3SUMO1 DKKL1 UCN2 SELENOFSUOX SLC17A9 MSH2 ATF2SURF1 CASP10 BC052578 /// RP11-398G24.2NOL8SURF2 COQ10B PARVA SHKBP1SURF4 PRPSAP1 LOC101928623 /// LOC401320DPP8SV2C NRP2 HN1 CLNS1ASWI5 MSH6 ETFA LOC154761SYCE2 PLXNB3 SLC25A23 HCP5SYNGR1 GALNT8 /// KCNA6LINC01000 /// LINC01001 /// LINC01002 /// LOC100132062 /// LOC100133182 /// LOC100133331 /// LOC101929819 /// LOC729737FMNL3SYNGR4 CREB1 PHF23 SNAPC3SYNM LILRP2 TRAC CDC25BSYT13 SMG9 ZNF862 APCDD1L-DTSYT17 GUCY2F NEURL3 EIF2S1SYT6 BRD7P3 PIEZO2 GSAPTAAR1 HNRNPD SEMA3G ZNF408TAGLN XRCC3 P2RX5 SLC35F5TAP1 FHL5 AGTR2 TMPRSS6TAP2 RALGAPB SPARCL1 PYM1TAPBP ABCA4 ASH1L COL5A2TAPBPL PARK2 MISP ZNF567TARBP1 ORC2 GNAL RSBN1LTATDN1 DIRAS3 IBTK FAM122ATAZ ARIH2 NAV2-IT1 MORN1TBC1D13 LYVE1 GOLT1B EFCAB6TBC1D16 KRCC1 PSENEN TMEM88TBC1D3C CASQ2 CTD-2537I9.5 VPS51TBC1D3G STARD8 DCXR NDUFA5TBC1D3H CEBPE ADAM9 STON1TBC1D7 FKBP1A /// LOC101929368SOX4 TSPAN1TBC1D8 C9orf91 METTL7A SWI5TBCK CYP2A6 RAET1E EXTL2TBK1 KDM4A COX4I1 SLC23A2TBKBP1 KHDC1L CTSO GNL1TBX21 PTPLB METTL13 ARHGEF1TCAIM KIR2DS1 FAM47A CAMTA2

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TCEA2 AK022030 /// TROVE2BICD2 MOB2TCEA3 MYCN LAP3 SPACA6TCEAL1 BEST2 CSNK1G3 COL6A2TCEAL5 AP4S1 RP5-1074L1.4 RASGRF1TCEAL7 MLF2 UTP14A RNF13TCEAL8 EPHX3 ZNF582 INSIG1TCERG1 MGAT3 NR1H2 PER1TCF21 MTMR10 LYPLA1 C16orf72TCF7 ID1 RP11-629O1.2 RCOR1TCHH SHPK /// TRPV1YBX1 RAPGEF1TCHP TMEM30A SAP30 TRPM3TDRD6 GRM5 GPR115 MGRN1TDRD7 CDKN2C TIMM9 GNASTDRP PCDHA5 GRB10 ZNF391TEAD4 REV1 TSPAN2 BRD4TESK2 ARHGAP22STK11 TUBGCP2TEX264 TSC22D2 TNFRSF1B PDCL3TEX29 MMP8 AURKA KPNA2TEX30 SOD3 HIATL2 PEX19TFAP4 LCMT1 YDJC PLPP3TFB2M NR0B1 TPRXL PPP1R16BTFCP2L1 MTMR14 FAM226A /// FAM226BTIE1TFE3 KCNK2 RPS17P5 /// RPS17P5 CDKN1BTFPI2 GABRR1 ASNS NALCNTGFB1I1 CPNE6 ZNF473 ITPKBTGFB2 NOD2 CEBPZ HSPB1TGFBR1 VPS13C KCNK10 PRPF4TGM2 NCR1 LOC644135 MRPL16THAP1 ISG20L2 CEP76 SPATS2THAP4 DDC NPFF PAIP2THEM4 CSGALNACT2GJB1 BOCTHEM6 ZBTB17 LINC01189 /// LOC101927827TAPBPTHEMIS2 TAS2R4 SDHA NUMBLTHRA ADD2 ASUN TSEN54THY1 IGF2-AS LOC389765 DHPSTHYN1 SOX10 MEIS3 TMED5TICAM1 TSPYL4 KDELC1 VDAC2TIFA HOXC13 PDZD8 CNOT1TIGD2 DARS2 RP11-433A10.3 TMCO3TIGIT NACA SRRD TMEM177TIMM13 MAGEA12 MARS /// MIR6758 SNHG29TIMM21 LINC00216 GNB1 GLI3TIMM22 PMFBP1 GINS1 ADGRA3TIMP3 NRN1 TNFRSF14 STBD1TINCR FUT7 DNM1P41 ZNF195TKT PALM NPW LOC103611081TLCD2 A4GNT IDE CALHM2TLDC2 PIP5K1C VNN1 ZNF775TLR2 RNF111 RAN TMEM267TLR3 COMMD3 COMMD8 ARHGEF15

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TLR8 ID2 FAM107A CD72TM4SF1 DRD4 PCBP4 VRK3TM4SF18 TCP10 FYB SEMA6ATM4SF4 PSG6 FAM13C TCERG1TM7SF3 PIWIL2 ABHD16A SLC39A3TMA7 KTN1 MLNR TMPRSS2TMC3 CHGA HKR1 DMTNTMC7 APH1A HNRNPA1 SCHIP1TMC8 HNRNPDL MYEOV SERF1ATMCO3 ASNSD1 ZNF606 RBM3TMED3 AVP LAD1 PRCCTMED4 SIGLEC8 ALG1 /// NAGPA-AS1 CAMK1DTMED6 SULT2B1 GOLT1A SLC8B1TMED8 WNT1 YBEY C1orf216TMEM106AFAM186A ZNF2 SOD2-OT1TMEM106CZBTB11 LOC101929480 LOC101927550TMEM121 OR12D2 YPEL4 GPR153TMEM125 ERCC4 LOC153546 TJAP1TMEM130 LGI2 IL12A GRAMD1ATMEM132CDTX2 /// LOC102725292NUDT9 NLRC4TMEM140 MAP1B IMPG2 TRAK1TMEM141 BCAP29 ASPHD2 LINC00957TMEM145 MTUS1 ZNF418 DRAM1TMEM14A PDS5B RP11-190A12.8 KARSTMEM14B NYX LINC00115 ARAFTMEM14C NDUFB4 NAMPT PAPSS2TMEM150CAK021537 FCHSD1 WDR37TMEM151AOPA1 PHLDA2 LINC01881TMEM158 OR2H1 PDLIM5 DHRS11TMEM163 GCKR HDGFRP2 NUFIP2TMEM165 UBA3 RP11-5C23.2 ZNF181TMEM17 FAM98A CRABP2 TP53TG1TMEM170AARMC8 MIR7109 /// PISD SMIM5TMEM171 FAM206A NME9 SORT1TMEM182 CAMK2A CDC16 NAGKTMEM183APCMTD2 MTERF1 ARSETMEM19 DAZAP2 HCP5B YDJCTMEM199 SETD3 CHKB KIAA0930TMEM2 ARHGEF4 STYXL1 CASP6TMEM201 GLP2R DAB2IP HLXTMEM204 PTEN CXCL3 ZNF738TMEM206 RPL10 /// SNORA70ZSCAN30 CD4TMEM215 SIPA1L3 MFSD5 ZNF394TMEM217 AC007967.3 /// RBMY2TP /// RBMY2TPSRSF11 HCN2TMEM239 SKP1 RAB32 GOLGA2P7TMEM240 SH3GL3 TPM3 PHB2TMEM241 MTHFD2 FEM1B LINC02449TMEM242 HTR3B SGK223 RBM33TMEM245 IGHA1 /// IGHG1 /// IGHM /// IGHV3-23 /// IGHV4-31DCTN1 UBAP2TMEM249 PUM2 ACACB BRD1

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TMEM25 ZNF669 TMEM86B TNFRSF11BTMEM253 POMT2 GTF2H5 MIR100HGTMEM26 MTERF3 LOC100130741 G6PDTMEM38A ODAM POFUT2 GAPVD1TMEM41B PRRX2 RP11-394I13.2 SSTTMEM44 PARK7 TMUB2 UBE2V2TMEM50A RHAG KIAA0141 ACAD9TMEM52 PPY2 ZNF780A ADGRL4TMEM55A CETN2 CRK LOC100652758TMEM57 SNAP91 SPDYE1 /// SPDYE2 /// SPDYE2B /// SPDYE5 /// SPDYE6ZSCAN22TMEM72 NDUFAB1 GNPDA1 FBXO34TMEM74 PNMT TAZ SCN1BTMEM80 ESPN MOXD1 DDAH2TMEM9 LOC100131510SORCS2 FBXO48TMEM97 SMARCE1 H1F0 CTSZTMIE LSM2 COA4 GCGRTMOD1 HIST1H3F ENTPD1 GLT8D1TMPRSS3 ARMC6 ESRRA ATG14TMSB10 RBX1 HMGB3P1 FAM3CTMSB15B ALPK1 LRRC48 COP1TMSB4X MUC6 LOC101930052 /// LOC102724562 /// MST1 /// MST1L /// MST1P2TENT5ATMUB2 HSPB7 FAM83G GLRX3TMX2 ETNPPL TTN-AS1 MAMDC4TNC APBB1IP RPL23AP32 EGR2TNFAIP1 ABHD4 PLEKHM2 TUBE1TNFAIP2 MCOLN1 WDR59 SLC35A4TNFAIP3 PAXIP1 AK021804 ALG13TNFAIP6 IZUMO4 EGFL8 /// PPT2 /// PPT2-EGFL8IFI30TNFAIP8 LINC00094 ANGPTL7 HAND2TNFRSF14 USP4 FERMT2 ARRDC2TNFRSF18 PURG CPA3 OTULINLTNFRSF1B TULP4 KLK10 AARS2TNFRSF4 SCAMP4 ARMC2-AS1 /// ATP5J2SGSHTNFRSF8 CTDSP2 PPM1K DUSP18TNFRSF9 OSGIN1 RNF123 BAZ1BTNFSF10 NDUFAF4 FLJ30403 ZNF85TNFSF13B IFNW1 ELK2AP PCP4TNFSF18 SCN4A DDR2 NTMTNFSF4 LIPE ZGRF1 KRIT1TNIP1 CCDC81 TOP1 ELF3TNIP3 SRRM2 HRAS ICA1TNK2 FNBP1L NACA2 NRSN1TNN NUP85 CSNK1A1 OATTNNC1 SAGE1 PITX1 N4BP2TNNI2 MRPL52 BC040646 /// RP11-732A21.2PDIA3TOB1 CCL1 SMAD2 PDXKTOE1 ATP2A1 SEPHS2 IL17RETOMM22 GPR161 TGFB2 MXD4TOMM34 GAST BC042374 PSMA5TOP1 CPNE7 LRP5 RNF170

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TOP1MT ACKR2 GPKOW KCNC4TP53I3 ACOT11 CDK5R2 RRAS2TPD52 P2RY4 ITGA2 ADGRA2TPD52L1 TCTA ZFAND3 ID3TPM3 FOXL1 IGKV1-37 /// IGKV1-37 /// IGKV1D-37 /// IGKV1D-37FAM78BTPPP3 DCAKD NPPC EXOC3L2TPRG1L RETN LOC101930097 SLC16A10TPST2 PRPS2 METTL17 LRCH3TRAF1 LTB BCL2L15 ARFIP1TRAF3IP2 OCLM GGPS1 CCDC30TRAFD1 ACHE GIGYF2 ZFAND3TRAIP MORF4L1 VCP NOTUMTRAPPC2L PRR34 FBXW12 EIF2ATRAPPC6A NONO BAG4 EMC8TREH C7orf69 HDAC4 HACD2TREM2 YY1 LENG9 APCDD1LTREML2 ABLIM3 BRI3BP PBRM1TRHDE LMAN1 MIDN MUC1TRIB1 FKSG49 ZNF835 RAI1TRIM10 POU5F1B COPS2 LOC285638TRIM14 EFR3A COPE ORAI3TRIM21 SLC12A5 PHB LOXL4TRIM22 HMGN1 ATL3 PACS1TRIM25 SLC28A2 RRN3P1 SNX21TRIM26 PLEKHB1 PKD2 GSTA1TRIM31 RDH16 RIPK2 SMNDC1TRIM38 ADAM10 FRK STYXTRIM40 RANBP17 TEP1 SHC1TRIM45 LOC101929336 /// RIF1PLAU CRKLTRIM46 LOC101929078OST4 CREMTRIM50 NMRK1 DENND2A CPT1CTRIM55 ASB12 /// MTMR8LOC100506289 SPTBTRIM56 PIGA GADD45A ENTPD3TRIM59 POLR1D MYO6 BHLHB9TRIM63 NBPF10 /// NBPF11 /// NBPF12 /// NBPF14 /// NBPF15 /// NBPF20 /// NBPF8 /// NBPF9C17orf70 KHNYNTRIM69 YBX2 FAN1 CLEC16ATRIM7 MED28 UPK1B TYSND1TRIP12 TRIM10 WDR36 LHFPL6TRIQK HADHB CTA-246H3.12 CD300ATRMT61B TP63 MPZL3 KCTD21TRNP1 FRMD4A PMCH HIF1ATRPM5 MIA ASCL2 KCTD11TRPM7 NKX3-2 ING5 MGAT2TRPV1 BPI /// LOC149684TRAF6 DIPK2BTRUB1 CDKL5 COX7A2 PHLDB1TSC22D1 EHMT2 ZNF83 NAA30TSC22D3 GRIP1 EBLN3 UCP2TSPAN13 ASGR2 SEMA4D EPCAMTSPAN2 CD6 DYNC1LI1 MVPTSPAN7 PAPPA2 FLJ45513 HMCES

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TSPAN8 SLC1A7 AK093256 /// RP3-486I3.7STIM1TSPEAR RAPSN WDR87 ETV6TSR2 ZNF536 MMD2 ZBTB44TSTD2 LOC101928830 /// LTA4HCOX10-AS1 /// LOC100506974PRR16TTC13 CIITA PES1 SNTB2TTC17 EPHA1 CUL9 SHOC2TTC3 PAX3 MMP14 PIGBOS1TTC39C TRPM8 ZNF836 LMO1TTLL12 PIBF1 CHD5 KCNJ2-AS1TTYH1 RRAS2 RP11-486G15.2 CICTTYH2 IMPG2 SNORD8 KHSRPTUBA8 SLC9A8 TPTE2P5 ACADMTUBB4A GK-AS1 /// GK-AS1HOMEZ GAREM2TUBGCP5 TMED1 UPF3A RIPK3TULP3 OPRD1 YKT6 FFAR4TXN2 SENP5 IFT27 ERCC3TXNL4A BTBD7 EIF2B2 MAN2B2TXNL4B MAG GOLGA8A /// GOLGA8B /// LOC101930583SLC16A9TXNRD2 INPP4A TRNT1 CD55TYMP AUH NUP205 SAP30BPTYSND1 NAB2 CLDN6 MST1P2UAP1L1 MPP1 GOLGA8CP /// GOLGA8DP /// GOLGA8EP /// GOLGA8F /// GOLGA8GZBTB11UBA7 B4GALT7 TMEM200B LOC646903UBALD2 AHSP PLXNB1 STX12UBD UFD1L RHOXF1 FARP2UBE2D3 BRS3 DLG3-AS1 URB1-AS1UBE2E2 MAOA GNG5 PSMC2UBE2L3 AKT2 RTN3 KBTBD8UBE2L6 CDH7 PUS7L PIK3R1UBE2O TMEM186 BMF LY6G5BUBE2Z UTP11L LOC102724200 /// TRAPPC10C2orf72UBE3D TRAPPC2 /// TRAPPC2P1KIAA1919 SF3B1UBE4B RPS6KA4 ETFB TNFAIP1UBR2 POLR2K SGK494 FGFR1UBTF CCT6B RP11-38P22.2 VPS50UBXN4 EPN1 PTPRO PRRT1BUCHL1 TRAPPC9 SEC24B-AS1 FGFR4UCHL5 PRMT8 FBXO41 /// LOC101927826LOC728739UCN2 SGPP1 RNF126 CELF2UFC1 OMD GRIA3 FOXF2UGGT1 BRD2 TNFSF8 ILDR1UGGT2 LARP7 HSPB8 SGSM2UGT1A6 OPRK1 NIP7 C14orf28UGT2A3 TMLHE RBM4B CDH10UGT2B15 WNT7B MTA1 SARAFUGT2B17 CACNG2 IDI2-AS1 PCBD2UGT2B7 F2RL2 TATDN1 ADD1UGT3A2 Igk LOC284513 FCGR2AUNC45A ZC3H3 FEM1A DUSP28UNC5B PLCG1 HSD17B10 S1PR1

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UPB1 CTSZ LOC100507507 TMBIM6UPK1B PHYHIP DDX11 GLAUQCRH TPSB2 RRAD CCDC163UQCRQ HOXC4 SPIDR RBM22USE1 APOB TUB UTP3USF1 ZNF143 N4BP2L2 CAPN7USF2 CCL13 FHAD1 PPP1R2USP18 PGLYRP4 HTATSF1 AP1G1USP27X CD33 SLC25A18 SCPEP1USP34 PIGH KIF12 ERI3USP4 TINAGL1 GTPBP10 /// LOC101927446ACP2USP41 KLHL24 SYNJ2 CCDC102BUSP43 SRD5A2 PRKCZ MTF2USP48 CLSPN MAD2L1 UGT1A6USP51 HAUS7 /// TREX2ARPC1B C2orf49UTRN PCMT1 URM1 AKAP1VAMP5 NGDN EIF4G1 HNRNPA0VASH1 NBEA TMEM200C ITM2CVAT1 MLN TMIE LEPROTL1VAT1L LOC101930405LYPD6B ZNF133VAV3 C3orf27 CES4A ASB6VDAC3 FMO2 COL4A3 TMEM17VEGFB FOXN2 MAPK8IP3 CD5VEGFC CCNT1 HIAT1 PTP4A3VEPH1 IL9R RAB11A PRPF3VGLL3 PRCP LOC100996693 /// SPEGSHTN1VIL1 GRK1 OPN3 SGK1VIPR1 MYO9A DCDC2 NEK10VKORC1 CTPS1 DDX26B FOXP4VKORC1L1 RABEP2 TMC5 TFEBVNN1 UGT1A1 /// UGT1A10 /// UGT1A4 /// UGT1A6 /// UGT1A8 /// UGT1A9ANXA2 SLC18A2VNN2 SPSB3 AP000525.9 ATRVNN3 TCP11L1 ANAPC10 BAG3VPS13C RCVRN B4GALT5 STEAP3VPS26B DLAT SZT2 FNDC10VPS37D GNAI3 SCML4 C19orf81VTCN1 ACE WHAMM HNRNPFVTI1B SMAD5-AS1TM9SF1 ZNF749VTN HOXD3 /// HOXD4 /// LOC401021ERI1 CASTOR2VWA2 RHPN1-AS1CCR2 TRIM3VWA3B JPH2 CTNNBL1 TVP23BWARS EPHB1 GNRH1 PIBF1WDFY1 ITGA2B CAPN8 CALHM5WDR13 MIR600 /// MIR600HGDAP PGRMC1WDR41 C1QA SERINC3 NOD1WDR49 DHX58 PAN3-AS1 ERICH2WDR5 MTNR1A MRPL49 SAMD9LWDR83 FSCN1 HSPA12B QTRT1WDR86 FAM60A CEP164 KLHDC3WDSUB1 STAG2 LDB2 KY

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WHAMM KIR2DL1 PAFAH2 YIPF1WI2-1959D15.1MARK1 SPRYD4 ARHGAP27P1-BPTFP1-KPNA2P3WIPF3 PTGIR METAP2 PRKRAWLS RPL3 BC065766 /// MALSU1CLYBLWNK4 TOPBP1 P2RX7 TIMM23B-AGAP6WNT16 CCPG1 REEP1 CCNCWNT2B DFNB31 MSTN RADILWNT5A SLC12A9 SYNGAP1 MYLKWNT5B BC069782 /// STAMBPL1HLA-DRB1 /// HLA-DRB1ARSKWNT7A MEF2B /// MEF2BNB /// MEF2BNB-MEF2BTRIM25 MYSM1WRNIP1 MAPKAP1 ARMC2 TFDP2WSB2 MZB1 WDR52 NTHL1WSCD1 MSTO1 /// MSTO2PWDR1 PIK3C2AWSCD2 KRT32 FCF1 LOC100505715WTAP FBXO24 GPD2 USP12WTIP DR1 MRPL33 SSBP3XDH PLAC4 SH2B1 ZNF503XIRP1 GPR31 DUOX2 MSI2XK PAQR3 VDAC1 LINC00683XPNPEP1 PLCB1 DIMT1 ATMXXbac-B135H6.15TNFSF18 BCL2L2-PABPN1 /// PABPN1NSMAFXXbac-BPG246D15.8HCAR3 LOC100130458 B3GALT5XXbac-BPG299F13.14PRDM10 LRRC14 WIZXXbac-BPGBPG55C20.2GAP43 LOC102724316 MITFXYLB DAPP1 MPZ PLXDC2YBEY HSPA9 ZBTB42 HMGN2YBX1 YWHAZ LOC101929857 /// SLX1A-SULT1A3 /// SLX1B-SULT1A4 /// SULT1A3 /// SULT1A4SARDHYEATS2 P2RY6 RAB29 LCAL1YPEL1 CLIC4 ISG20 C9orf131YPEL5 GSN-AS1 ARMC6 MCCYWHAH SMAD2 TTC8 CAMKK1Z83851.1 RRAGD BDNF NFKBIL1ZADH2 FUZ NACAD IL6R-AS1ZBP1 RAPGEF2 NICN1 SDK1ZBTB12 SP3P CHCHD3 PHF1ZBTB18 ERGIC3 POLL RNF216ZBTB20 MPZ TRIM7 SGCDZBTB42 ZC3H7A LOC102723600 /// MIR1302-10 /// MIR1302-11 /// MIR1302-2 /// MIR1302-9IFT43ZBTB7C ST3GAL6 HMGCS1 ZNF74ZBTB8A HOXB3 LOC100507468 DDX41ZC3H12A SAYSD1 EPHA10 PRDX6ZC3H12B PTPN12 ATP5D RFC2ZC3HAV1 SIX5 ZNF224 EFNA5ZCRB1 PCYT1B ARSI CCDC9BZDHHC1 YTHDF2 DYNLRB1 MTFR1ZDHHC13 ABCC4 LOC642852 WDR13ZFP36 SLC17A6 TREH SYNE2ZFP62 LAX1 TAAR8 ZNF569ZFP69 SARAF C21orf62 ACP5ZFYVE27 TEAD4 KRT18P44 /// KRT18P44IPP

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ZKSCAN1 LOC100505534KIR2DS4 SLC39A10ZMYND19 PLD2 MB ANAPC5ZNF121 IKZF3 CTAGE4 /// CTAGE8 /// CTAGE9ZBTB7CZNF148 TLX3 GTF3C6 RPS10P7ZNF174 MAGEC3 GRB2 PHRF1ZNF226 HTR7P1 TTC17 APTXZNF23 IL2RG ATF6B APMAPZNF267 LOC101928717 /// SLC19A1LOC101060181 /// LOC101928574 /// ZNF44SLC7A8ZNF276 IQGAP1 ZNF782 CEP162ZNF284 MIA3 ASTN1 SPOPZNF296 CTAGE11PLL22NC03-N27C7.1 /// ZNF70C16orf70ZNF3 ALOXE3 KIAA0319L ZNHIT2ZNF30 YWHAQ CEP162 CENPVZNF318 FLI1 ZNF92 APOA4ZNF32 ZNF446 BCO2 CHL1ZNF33B TAF1 CYP2U1 RAPGEF5ZNF34 DHDDS C12orf45 NBPF3ZNF346 PIP5K1B GHITM LOC101930085ZNF358 FGR DRG2 CYSTM1ZNF423 HARS /// LOC101928623ARHGEF17 ALDH1A1ZNF428 XAB2 KLKB1 CRCPZNF438 PELO DRICH1 NGLY1ZNF493 MAP4K2 PCTP SSTR5-AS1ZNF524 APBA1 ITPRIPL2 GOLGA6L5PZNF544 ATN1 SLC26A8 NUDT11ZNF568 SLC6A2 SMIM20 PIGTZNF575 MED25 TDRG1 HAPLN4ZNF648 WASF3 PQBP1 DLC1ZNF664 ITGB3 LRIF1 ADAM19ZNF667 DSCR3 SEPT7P2 ASNSD1ZNF667-AS1GRIK5 PQLC3 CFHZNF684 GTF3C2 RP11-112J3.16 ZDHHC12ZNF708 IMPACT EBLN2 ROBO1ZNF738 RSPH6A MTMR11 DYRK3ZNF74 TIMM17A IL1RN NRBP1ZNF771 NPM1 GCM1 FMO4ZNF781 BTBD18 DEPDC4 PERPZNF792 LDLRAD4 ACOT9 FAM107AZNF814 MAPK6 DERL3 THBDZNF833P HGH1 KIFC2 FAM168BZNF878 EIF2AK1 RPL36 CLDN11ZNF883 WNT11 NUDT11 NID1ZNF888 MS4A5 AC008746.12 F2RZNF93 NR2E3 APC TPI1ZNF98 TOX ABHD14A /// ACY1 DDX56ZNFX1 IRX4 SGK2 CAPN10ZNHIT1 HMGN4 PHF1 RPS6KB1ZPBP DLX4 FGD1 SOX4ZPLD1 HOXC10 LOC283038 TMEM204ZSCAN21 NUFIP1 CA3 GPR160

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ZSWIM4 EPS15 SNAI2 SAP18ZNF747 /// ZNF768GIMAP7 PARP1PRPF39 ITGAX SLC39A1HR TFAM SAMD8APBB3 /// MIR6831ATG14 COL5A3SLIRP AMMECR1 TBL3TSNAX RP4-581F12.1 NEFMBTG3 CAAP1 CALM3ARL8B OTUD7B BPHLMBTPS1 UNC5D CWF19L1PSMA2 D2HGDH CALML4PRRG3 CXCL12 TDO2ACPP LOC101929328 PTPRDSAMD4B RP11-389C8.3 CCEPRFASLG SLC2A6 NKX2-3HPD CIT /// MIR1178 ATP5IF1PAIP1 SCARB2 RMC1HOXA1 PUS3 BMP1RAD17 SELO PLEKHA5ELMO2 SCFD2 PTPRSMAN2A1 UFSP1 TMEM62ATP6V1C1 DLST PCDH18KIR2DL2 RNF146 ANKHD1KIR2DS3 ZNF160 CALD1HTN1 BCAM KCNJ14ABCC10 ARSA TRAPPC8SPDEF LOC101927451 SDHBACTL6A PPP1R14D ZNF41MKRN7P LOC100131508 NDUFAB1ARFGEF1 POLR2F RWDD4CCL4 FAM47C UBXN11TMEM35 ANP32B COX6B1MRC2 EPB41 FTOEIF4A3 SH3BGRL3 STAT3TEK H3F3A /// H3F3B /// MIR4738OSTF1SAP130 UGCG NPC2UBE2V1P9 /// UBE2V1P9B3GAT1 LIN7AGJA8 CLDN4 DNAJA2LOC100506124 /// TTC21BTAF8 TMEM199APOL6 HP /// HPR UGT2B7GPR162 CATSPERB PCDHB10NRIP2 MRPL12 LRPPRCCARM1 DDX11L2 ISOC1SEMA3G CHD1L ITGBL1TMEM38B EMILIN3 ZCCHC18UBE4A CASP6 DGCR2RYK OGN MAP6OR3A3 RP11-248J18.2 ZNF334CNTNAP2 SOCS7 CYB5RLMED1 LRRC8A TIGD6

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ROBO4 GUSBP1 /// GUSBP4 NPATMAP1LC3CITSN2 ZBTB11-AS1AQP6 ID2 APOBEC3FDSCC1 BCCIP ZNF747ITGB7 SERTAD2 PDE3AACYP2 /// LOC101927144TUSC2 RRM2BE2F5 IFNE SNAPINEIF3H RELB NRGNRARRES1 LOC284865 ATG9ADLX2 HMMR SCARB1TEX13B LRPPRC MAP4K4CLCN4 RP11-258C19.7 PAX6CTB-176F20.3LRRC8E PRMT6GDNF PPIEL PLIN3CCDC91 FAM188B /// INMT /// INMT-FAM188BC8orf37SUCLG1 LOC102725383 WDR82SSTR4 ZNF334 LNPKCTD-2269F5.1LGALS4 CD36CD160 ELK1 MBTD1HSD17B4 FAM84A SLCO2A1IL4I1 /// NUP62PDZK1IP1 KINGGA3 RUNX1-IT1 XPCKCNH1 VMA21 SNHG15NPHP1 SNHG16 /// SNORD1A /// SNORD1CMTBPBTN2A3P ORC2 CCN3CHD2 RP11-216L13.19 ATP2C2GTF3C4 LOC100507487 /// LOC101927184ULBP1LDB3 MMP3 AAR2RPL23A OXTR IP6K2RP11-255C15.3TMEM43 BNIP3PPP1R7 COX7BP1 /// COX7BP1INTS6LPPP3CA TGFA WDR75ETV2 NDUFAF3 LOC283335PYGL KCNK13 GALNT14LHPP HINT2 FOCADCYP2C9 ZNF256 DEAF1ERCC3 GARNL3 FDFT1ACADS STAT5B ABCF2FCGR2B MRPL17 MAP10CASQ1 SERPINE1 ABHD16ARORC TNFAIP6 ZDHHC4ALX3 ERCC1 EXOC3-AS1HLA-DRB1 /// HLA-DRB1SH3PXD2A OMA1PDE6A LOC101927719 USP49RNF41 LYAR RGS14RP5-882O7.1LRR1 FAM43AMDN1 VSTM2A NFIL3GUSBP11 DTWD1 GLMPERV9-1 RAB6A /// WTH3DI ASNSNPIPA5 /// NPIPB3 /// NPIPB6 /// NPIPB8ELAC2 SMN2

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FECH MAMDC2-AS1 AVPI1MPHOSPH6FDPS GLSBPHL HOMER2 LOC107985939LOC102724905PSMD10 PAG1KRT8P17 /// KRT8P17CBX1 SLAIN2HEXA STXBP2 HOMEZZNF629 TBRG1 PAM16B3GALT5 RP11-95H11.1 UBXN6MASP2 FAM220A TANGO6TRIP12 IL23A MYO15BFBXO9 RP11-91I8.1 ALKBH7PTP4A1 DDX19A /// DDX19B DHX38HOPX GRIA2 PPP1CBAMN TNFSF15 GRIA2PSIP1 RP11-285J16.1 ADAMTS7CNTD2 NME3 EI24EFCAB1 LINC01091 PRPF38ACKMT2 DTL DAPK2ACTN3 RP3-525N10.2 PCAT19IGLV1-44 NUDT22 UBA1PARP4 MED10 EDRF1CAPN3 CASC15 ADAT1CLPTM1 USP40 PCDHAC2WDR1 ABCC6 /// ABCC6P1 /// ABCC6P2 /// LOC101930322U2AF1SLC22A18ASARFGAP1 PHIPZCCHC8 PKLR ACAD11FAM3C SRSF4 CEBPBZNF146 ANAPC4 TNFRSF10BTNFSF11 SLMAP EFCAB14SHMT1 ZBBX MAPK11GML TAF12 BCL9CTBS WBSCR22 PPP1R14CFBXW2 RHPN2 OARD1P2RY2 RP3-334F4.1 MARCHF4DPY19L4 RFC2 C20orf27CBX2 C4BPB ZDBF2LRFN4 LOC439994 /// LOC642361SEC61BAC012065.7TMEM163 FGALEF1 ARL4A DUSP8CDH16 COL21A1 CHP1RRN3P1 SCARNA13 /// SNHG10NUDT16ARHGAP29IL17C UGGT2SQRDL RPP21 /// TRIM39 /// TRIM39-RPP21ADAMTS17GRM4 PDAP1 RO60ASH2L DDIAS MDC1RDH11 RP1-78O14.1 ARHGDIBTTR BOLA2 /// SMG1P2 /// SMG1P5ASIC1ATP5O TSC1 PRR3PSMF1 BVES SCO1EPS15L1 RP11-295P9.12 RPUSD4

Page 106 of 781Diabetes

LOC100288974 /// MBL1PADARB2 SSR1MYO1F EPRS KANK3CDC25C ZNF211 C14orf132FAM110D TNFAIP3 PARP16CEP192 COPS6 CBWD1NDUFS1 VCPIP1 SLC9B2ZNF202 LOC283861 KLHL11PPP1R16B NBPF8 TNS3C8orf44 IGDCC3 CSRP1SCN2A ANKRD44 CDC27GPATCH2L F13A1 LIN7CTNFRSF10CALDOB PUM3EMCN NPM1 IFNGR1DAO C2orf80 CNTN1RASA1 ANAPC13 KDM5CKDM1A C16orf89 H6PDSLC39A8 UBAC2 THAP11CHMP2B LRPAP1 ST8SIA4ZNF132 RP3-368A4.6 NDUFB4PPP2R4 HLA-DPA1 LSM2CEP164 TLR5 SIN3AKCNC2 NGFRAP1 TMEM33RPS4XP2 /// RPS4XP2ZNF672 CASTOR3SSBP2 CDC25A OPCMLRNF7 TFAP2C ARG2HPSE2 PLXNA2 IDNKC19orf80 LOC100506098 RTL5C2orf54 AMDHD1 ALG11ATP6V1G1 LOC101927206 EVA1CFERMT2 FGF13 COG2MPP5 SPPL2A CCNYAQP5 ACAD10 PPP1R8GPR137 TCAIM FAT1SAP30BP CTXN2 /// SLC24A5 MCUBPCTP RAD23B GPIBGN ATR DUSP6NAT1 PCNT DTX4GLRX5 GALK2 RAB43SYPL1 RCCD1 PJA1LOC101930602 /// SLC14A2DUOXA1 ZFAS1ACE2 CHRNA9 FRG1HPMIR5193 /// UBA7SMAP2 SLC17A5PTPRT ADH1C DCTN4ME1 FUT2 CYTH2COLEC10 DPY19L1 TRIM34BIN2 TSLP MSRB1RBMS3 INHA TMEM45BLSM4 MANBA TBPL1ELAVL1 SPATS2 NECTIN1ATF6B /// TNXBREST SLC6A6

Page 107 of 781 Diabetes

CRK TMEM14A ZNF204PTBX4 MND1 PHF11ADCYAP1 LAT OLFML2BPCDHA5 /// PCDHA6REPIN1 ST3GAL5-AS1ELAVL3 SSBP4 TTKATG12 HES5 PRR15CSNK1A1 ADCY4 POU2F1RNASE3 FAM78A /// LOC101927137GIPC3TP53TG5 AAAS PIGXZMYM6 /// ZMYM6NBCYB5B RBMS1NAT6 RELA POLR3GLZNF609 LOC101928230 GLG1

ZXDB LOC100286925RFT1 TCP11L1N4BP2L2-IT2 TBC1D1CAPRIN2 MKRN1TRMT10B SECISBP2LCOTL1 PRSS16COBLL1 MED1KDM8 PLS1ZNF311 SLC35C2SIX6 RPL17-C18orf32UBE2G1 HES1LOC100996717 /// LOC100996763 /// LOC101929796 /// NOTCH2 /// NOTCH2NLSLC66A3RBAK ABITRAMLMF2 FRAT2TLCD1 MBLAC1KRT73 ZSCAN32AC005785.2 CA5BP1VENTX TTC25RPL15 STC1DSC2 MSANTD2RP4-710M16.1 CACTINHCG27 KCTD5NAPSA MAP3K13UBE2Z SLC37A1FAM92A1 CZIBLINC00629 RAC3GLIS3-AS1 SYT17SLC25A14 UNC13ANEBL SLC22A5CIB3 ZSWIM5GTF2A2 FESPON3 ADPRHRBPJL NUDCD1SYT16 GASAL1TFF3 LCA5LGOLGA2P7 /// LOC101929479 /// LOC642423 /// LOC727751 /// LOC80154MAP3K8NMB VAT1SGSM3 SYMPK

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CHD1 ARPP19OR2L13 PIK3CGRPP14 RAD17N4BP3 PKIGPA2G4 TMEM87ALIN9 PDE3BIL13RA1 PDE11ASLC5A4 THAP7MUC20 RBM19AC007255.8 /// BC038570TPP2TFPT RAD23BTMEM54 ACTBLINC00893 SLC16A6RP11-1078H9.6 ZNF469GTF2IRD2 BABAM1DAPP1 PUM2ANKHD1 /// ANKHD1-EIF4EBP3WDR33THAP11 PPP4R3AEPHA2 UTP14AAK054988 NEURL1SEMA7A PPP1R12CFCER1A PIRCDC42SE1 SH3PXD2BGATS ZXDAETV3 CROCCSWI5 NOL9CAHM DERALOC100506639 IGF1RTCF4 AUHRP11-109D24.1 RTN2ZNF404 MKNK1PAOX SIK1FGD6 SIK1BMTAP TMEM35BDCAF15 RNF25SREK1 STARD9MFN2 PTGISLOC100996643 /// LOC101928195 /// MTHFD1LDHRSXDMXL2 SPIDRSEC31B MYRFTDRD10 PLXNA1CXCR6 NINZNF91 OLR1PEX1 PPDPFMCM4 HMGN5NEMF FCHO2DDX55 TVP23CAPOBEC3F MS4A7C1orf162 MRPL10ATP6V1E2 PTPA

Page 109 of 781 Diabetes

IFI30 /// PIK3R2 DGKHNME6 GIMAP4FNDC3B /// LOC101928615SLC25A39C6orf211 SLC44A3-AS1LOC402160 ZNF668ZNF644 NDUFB6HSD17B1 TRIM28IFT20 ACOT7L3MBTL4 ZMYND8HACL1 GTPBP1RGPD3 /// RGPD4 /// RGPD5 /// RGPD6 /// RGPD8BBXHMOX1 PTPRBDNAH6 COLGALT2HLA-DRB4 LRFN5DNAJC5 SNX15FAM63A UFD1INO80B /// INO80B-WBP1 /// WBP1ASB9EYS MAU2GAPDH LCMT2CDYL ABALONNXNL2 SLX4CPPED1 ARAP1SLC39A6 STARD4-AS1CREB3L4 RAD50GSTP1 PGAP2ABLIM3 STAU2TPMT ASB7PRDM8 SPRY1POU4F1 LINC02606SLC44A4 EIF4BTBC1D9B GALNT12PEX6 GUCY1A1PRO1082 ENC1TIMM17A LOC100506100TIMM23B FAR1RHOA GTPBP8ZNF335 ACAT2FMO3 IGSF8DNAJC1 CSPG4RICTOR TUBA4ASPRR1B LINC01833FBXO36 PTPN9ZMYND8 EP400CPM CCDC117RHOF STX16-NPEPL1LUM SHISA6RP1-8B22.1 CFAP298LHFPL2 VWFDAND5 SNTB1NPC1 POMT2

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MRPL24 MARCHF5ANKRD13B ZNF593FBXO34 ZNF286AABHD17C CHIC2GPR62 PDLIM4SYAP1 LINC01137CYTL1 BEGAINCUL7 GTF2E2CXCL1 C22orf23PHKA2 DMAC2TRIM46 TAGLN2GABRR1 MAOALOC100128751 MEIS2HMGA2 DNAJB5LOC101926959 FOXQ1ACAP3 IFT52CCDC64 ZCCHC8LINC01137 SRBD1NALCN-AS1 LRIG2MST4 PLCH2HERC1 NAT10MIR7111 /// RPL10A GATMG0S2 RASD2RPL23 /// SNORA21 NCKAP5ASIC1 CYP26B1OR7E156P SYCP2LCR1L TMEM101LOC100507073 KLHL13HECTD2 TIGARATP9B HPS1TLDC1 TPCN1DOCK7 PCDHGB6FOSL1 LRRC6STARD5 SQLEATP6V1F /// LOC101927180BTAF1GPX2 AKT1CNOT7 ZNF124LSM1 SMYD3LOC153684 MAPKAPK5IFITM1 IQGAP2ERCC8 DYRK2LOC101928020 ROBO2FAU RAB5IFC1orf94 TMEM233ANGPTL2 STRA6RP11-416N2.4 COQ8ALOC644794 FAM210ASPG20OS KLLNPCDHB9 NFATC3HNRNPUL2 /// HNRNPUL2-BSCL2DZIP3

Page 111 of 781 Diabetes

AF131215.8 ST6GALNAC4WASIR1 /// WASIR1 /// WASIR2 /// WASIR2ARHGAP25FMO1 SPAG9GPI SYT7CPSF7 ACAA1LOC101930657 POMGNT1LOC100272216 SAMHD1FAM103A1 COPS4EIF3J HNRNPDLKIAA1671 NCAPGCOMMD5 /// LOC101928879 /// ZNF250MARCKSL1ATP6V0C RAP1GAPWDR89 DLG5AKR1C3 USP3P2RX5 /// P2RX5-TAX1BP3 /// TAX1BP3NOTCH1UCP1 CDC16PROX1-AS1 METTL26MPP6 DDX60LAF086288 /// RP11-768F21.1RPRD1ATMEM219 SAPCD2ZNF747 /// ZNF768 POLR2KCCDC59 CTU1NUP210 CAVIN2BNIPL /// C1orf56 RNF135VAMP3 LSM8RP11-37C7.3 WAPLARMCX3 ARL16FCGBP ITGA4PITPNM1 VWA2LOC100128108 HPS5TEKT2 MXRA5CENPBD1P1 ARHGEF10ARMC4 TMEM169PCDHB1 LMCD1SPACA6P ZNF341LOC102546294 CCDC28BUBXN10 KCNG3N6AMT2 SSBP4IDNK HECTD3DSN1 SSTR2H3F3A AP1M2CHRDL1 POLEATP6V1G1 LIMD1UBTD2 CPEB4LINC00610 ZNF584UCHL5 THTPAINTS10 LINC00869KL CPNE2ARID4B QPRTFGF12 PCNP

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F2RL1 PLEKHG5ZBED9 KIF5ARP11-109M19.1 LDB2SEH1L CDC37BRSK1 TLN1CRTC2 RCHY1NXT1 FOXJ3ZNF767P MDGA1CPQ CTR9RPL27AP /// RPL27AP NIPSNAP3BCOX5A ESYT2TGFBI ITGA5CLCN6 DDX31ATG4C ESM1AKR1C1 /// AKR1C2 /// LOC101930400LONP2SLC22A1 MIS18BP1FBLN5 SCML4PF4 ARVCFCADM2-AS1 USP46-AS1ATG13 ELOCCYP2C8 RARA-AS1PHF21A VAV2TUBE1 DENND4AGIMAP4 ACTR3CSUGT1 BCAR3RCC1 BHLHA15LINC00284 LAYNTPSAB1 DAB1LOC102724316 /// PTCHD3P1RAC2C1orf204 BRICD5KRBA1 A1BGARL5A /// LOC101929356RPGRCNOT6 SVOPERICH3 MGAT3HBEGF PCNX4TOM1 ANXA4DEFB4A /// DEFB4B ECSCRLYRM2 DTNBMIR29B2 /// MIR29C TRPC4APSNX3 ZNF30SNORD50A /// SNORD50BZNF322LOC101927668 /// MACC1EIF5ACNNM3 MAGI3CIITA DNMT3BTRIM14 PKD1P6-NPIPP1C18orf32 /// RPL17 /// RPL17-C18orf32TMEM14CFAM193A CHPF2MSMO1 FAM76ALAMTOR3 PPTC7ADAM29 /// LOC101928551CLCN2

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PGM2L1 LOC100507071ZNF655 GRM1LOC101928687 PCDH17C15orf45 SCN3BRND3 CACNA1BLINC00667 ALDH5A1METTL25 B3GAT3PPIL1 F11IFITM10 PLEKHM1P1CEP290 DOCK1LSM5 TPT1GSS MCUABCA5 TRIM13SDR16C5 UHRF1BP1LLOC102724967 LPIN2RP11-613M5.1 ANGPTL4BHLHE22 MORC2SHPK ADAMTS6RP11-465B22.8 CERKTRUB2 CHCHD2BTF3L4 EIF3KTMEM214 CUL2FAAH2 POLR2DMAN2C1 SH3BP5LPAQR3 SPATA20NEDD1 FLJ42627PFDN2 SLC17A7NXPE4 LBHMIR424 /// MIR503 /// MIR503HGTRMT11ROR1-AS1 MMADHCUBE2N ERMP1PRR14 SERTAD4MSL1 KCTD12NANS ADAMTS12RP11-1L12.3 RAB4BCANT1 TTLL6KIF11 CSRNP3ANKS1B NDUFA10MYL12A MARVELD2CORO1B ARHGEF7TRIM54 MSX1ADRBK2 TTC33MRPS15 XPO6SRGN GSPT1ISX CHGASLC1A1 SPRYD4EIF5B SLC38A2PRMT5 SPNS1RP3-507I15.1 GRNRAB14 PHAX

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C21orf67 PDCD11LOC100506248 /// LOC728026 /// MIR1244-1 /// MIR1244-2 /// MIR1244-3 /// PTMAADCY6CCDC11 REG1ASLC35E1 LINC00665LOC103344931 COMMD2NCAN ATICRFC3 ZNHIT3TNFAIP1 ATG12MAP1LC3B ANKRD37PLD3 SYNGR4ACOT7 FXR1LOC102724537 SP2ARFGAP3 NLNDDX54 SGK2SH2D4A SCXCHD8 HDHD2C2orf16 ADNP2RGS7BP NRF1RGS13 HOXB2C21orf58 UBXN4URB2 MBNL1-AS1PYGO1 PCDHGA5HYMAI ULK4RPSA /// RPSAP19 /// RPSAP58 /// RPSAP9 /// SNORA6 /// SNORA62TXLNANABP2 GNG11NKX3-1 IRF8SGIP1 GAL3ST4DCAF8 MOB1BBACE2 FGFR1OP2KIN MED31LOC101928101 RGCCDHRS3 CNKSR3LOC101929336 /// RIF1ECSITSH3BP5-AS1 MTCH2HDAC8 CRTC3CC2D2B NSD3CRADD TNK1C19orf40 INPPL1ACAD11 /// NPHP3 /// NPHP3-ACAD11IQCKTNFSF13B BTBD7FBXL13 HSBP1L1CD2AP UBE2FPDCD6IP KCNAB3CCL26 GLCCI1C4orf17 AGTR1UQCRH /// UQCRHL MRVI1PFDN4 SMPDL3BPPP6R1 PMP22ASPN MPHOSPH6MMP7 ACOXL

Page 115 of 781 Diabetes

NUDT10 RBM26LOC101928100 OAS2TOX4 ATRNL1MEX3D TRIM50PHF20 CCDC61PPP3CA TUBBP5MICALL1 PNMA8BHIST1H1C ARRB1ERBB2IP XPO5PBX1 KLF16MOB3C DNAJC24ATP10B ANKRD65ZPR1 BUB1BC1orf101 UBE2D3ARL8A SUSD2PDLIM3 TNFAIP8L1FOXO6 TJP1PTMA INAFM1CTTNBP2 CUTANUP153 /// RP11-500C11.3CSNK1G2CDH10 ALKBH1DHTKD1 HDGFL3PLIN4 DNAJC22APOL5 ZXDBSFTA2 SCOCRPL7AP10 /// RPL7AP10LRRC73COPS7A ERP27FAM104B RPA2CAT ZFHX2SERTAD1 DCHS1ART3 AP5M1IFT88 ZNF460GRTP1-AS1 /// LOC101930007 /// LOC101930262SH3PXD2ARP11-111M22.4 CCDC28ATTC1 L3MBTL3LINC00925 SNHG32LPL IRF2BP1GCNT3 COPS7APDZD3 HNRNPUL2KDM6B FCSKPRSS53 ABRAXAS2ATP6V1G2 FEZ2KIR3DL3 VAT1LACTR2 GTF3C6ASCC3 FBXO2BRAT1 NGDNRP11-250B2.3 IL17RCZBTB34 CBLCSLC30A6 EIF3AARIH2 LOC729970

Page 116 of 781Diabetes

PLEKHF2 KCNK9LOC100506834 PRMT9RNASE4 PSMB8MGC70870 REM2SHANK3 MORF4L1NF2 CMKLR1MURC GSN-AS1AF086126 /// C16orf52SPTLC1ARHGEF33 LINC01521LOC100131541 SUMF2LECT2 IKZF2CLK4 DYSFLINC01279 TRMT13WDR35 PAK5PRIM1 YES1KLHL17 ZNF135DHCR7 PRR19ATP11A-AS1 SPEGPLIN1 MDFICCNIH1 THRAP3AKR1A1 SUMO2SHB CCNITTC23L ZNF117B3GNT3 TBX2LSM12 RTN1ADORA2B PRXL2APPP1R21 SNX6WAS GRPEL1C3orf58 SNTA1PSMD9 TMEM14BRP3-522P13.2 LOC101927245KCNK3 GBP4IKZF4 NKAPD1CFLAR-AS1 TTLL3GDF15 RALBP1CKAP4 MTMR10TRAK2 PCGF1OLFML3 SF3B4HLA-DRB1 /// HLA-DRB4 /// LOC100996809GMPPAHS3ST3A1 BOKFCN1 NFXL1LBX2-AS1 LOC100506142RBP1 PCED1BGNG12 CLIC2YIPF5 LOC728743TYW5 TM7SF2MIEF2 ZBTB10XKR7 RPUSD2CYP1A2 CRADDALDH4A1 ZNF582

Page 117 of 781 Diabetes

USP7 SLC17A6SLC35F4 LETM2DIO3OS /// MIR1247 PLEKHA7RBM25 PROZTRIO LOC102724908PSMD5 TMEM108TMEM104 RC3H2TNIP1 TSPY26PPEAK1 PI4KBSUPT7L LOC100133091KISS1 ZNF761TP73 AMER1NAPG DHRS3AP5B1 MSR1LOC101060321 /// LOC101060351 /// LOC101060376 /// LOC101060389 /// LOC102723859 /// LOC102724862 /// TBC1D3 /// TBC1D3C /// TBC1D3F /// TBC1D3HPSENENSRI SLC7A6OSFAM122A ADAMTS4C1orf106 JAGN1RFX3 FMN2NAPEPLD MED20KPNA2 CMTM6CD59 CISD3IRX4 LINGO1PMCHL2 SGPP2OR7E14P RBPMSCDC42BPG UBE3DRPL39L ALMS1P1ADAT2 LOC100287808METAP1 LMAN2LANGPTL1 MFAP2FLJ45482 U2AF1L5PALB2 VIL1CHMP2B P2RY6TFPI2 UBE2Q2P2CDKN2B-AS1 JMJD1C-AS1SRP72 POC5RNF168 LIPGJUP /// KRT17 SLC15A2KIF4A TTC7AKCTD14 /// NDUFC2-KCTD14LOC101927752CFL1 NFE2L2PLGLB2 CGGBP1RP11-255A11.4 SRSF1RAB22A ZNF268CDRT4 /// TVP23C /// TVP23C-CDRT4ACACBARL17A /// ARL17B /// LOC100294341SULT2B1MDFIC CCDC106PLLP KCNJ6LMBR1 LSP1EPOR PPP1R3D

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TRIP13 LINC00674LOC100270804 UBE3ADQ586822 ISG20PALM TET1UBE2H KCNJ8CTB-102L5.7 TMTC4RPRD2 BEST3PLEKHA8P1 C2CD4ACEACAM7 UNC5CLSLC27A3 DDX10RP1-20C7.6 PALMS100A16 RARGUSP43 NDUFV3LOC100289097 /// LOC642236FAR2P2TPR LDHBCD3E KCNK17CACNA1I GNB1LAGGF1 DIPK1BZIM3 ZBTB9CMPK1 C12orf10LOC101929622 ECPASHHIP-AS1 TOX2GLRX5 C4orf3PRPH ANAPC1RPL13A /// RPL13AP5 /// SNORD32A /// SNORD33 /// SNORD34 /// SNORD35AITGB8PDCD4-AS1 RPP25LSTMN1 FARP1FAM107B LOC100506258EDN1 SERPINE2PCF11 CRYBA2PPARD MISPSETD1B SULT1A1JPH3 ARL6PIK3R6 RASL11AJMJD1C-AS1 WNT9AEXOC1 KPNA4SSR2 SLC7A2RAPGEF4 ZNRF1FOXQ1 LINC01099LOC101927137 /// SCLT1LINC02159ALKBH2 CRYBB2P1LOC100507547 /// PRRT1SOWAHCDUOXA2 ZBED5-AS1SDHD IQCDC5orf51 LOC644285USP3-AS1 P2RY1SLC25A36 DONSONMAP2K6 ROR2CDC40 ABCD1CTSG NEIL2

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GBA2 CSDE1ACTB /// ACTG1 LAS1LTAPBP PCDHGA3NDRG1 FPR3RPA4 IP6K1TFF2 SPTLC2SNAP29 H2AFZSLC26A2 STK32ALINC00494 ZNF576MVP E2F5BC022892 GYS1CMTM4 GPR27TMEM127 MAP2K7SNX14 BCL11ALPIN1 PLD6SLC25A32 CD248SLC35G2 PCDHGB7RP1-193H18.2 RMDN1CRTC1 SYNJ2ANKIB1 TCHHPKD1P1 YWHAQGLIPR1 LGALS9DZANK1 MZF1-AS1LINC01106 /// LINC01123POT1AP4E1 CDK5RAP2C2orf42 PCK2CLTA PCDHB15ALKBH3-AS1 ZNF581HSPH1 CANXRITA1 PJA2TOR2A ZNF583LOC101928111 SH3RF3ZYX CSNK2A3KHDRBS1 PCDHB7PWP1 TLE6GANC SYNGR1C5orf28 TMEM170ACCL2 HPGDZNF133 BTG2FAM21C /// LOC101930591TMEM43ZKSCAN5 WDR53S100A11 WDFY2RP11-171I2.4 ACADSCWF19L1 NDE1C9orf89 MYCT1C10orf107 LOC100499489HIBADH STON2AKIRIN2 ZFHX3PPAP2C ETV3GTF2E2 ARHGAP18

Page 120 of 781Diabetes

CD58 EML5MOSPD1 LINC00641LOC101928278 RUNX3PACS2 PRPS1ERI2 IGSF11GBE1 OGFOD2FAM66B /// FAM66C /// FAM66D /// LOC101928910 /// LOC102725108ANAPC13BOK SLC39A8TUBA4B HSPH1ZNF771 ENDOVLUZP6 /// MTPN LRRC59FAM65B TTC39AHCN3 CKMT1AGTF2H2 /// GTF2H2B /// GTF2H2C /// GTF2H2C_2AASSTMEM125 PCDHGB1TMEM217 TNFSF10FABP6 TDGCDC20B MTURNTMEM19 AP1G2LOC100507054 KLHL24PJA2 CRBNKIAA0753 CORO1AKIAA1683 PATL1PRPS1L1 CLIC6DKFZp564H213 URODBATF2 PSMC3RP11-288H12.4 DNAJC21CUL2 HEY1SH3PXD2B KCTD1UBN1 SLC35D3SGCA GADD45GSPRED1 USP51TIGD4 MTG2B4GALT1 ZFP69BBPIFC SLC36A1DRD2 KIF13AOLIG3 PPIDRARB CALB1LINC00921 /// TIGD7 /// ZNF263STRADAHYLS1 PDE1BGFM2 GAS2ZNF101 SLC12A7RP4-773N10.4 GRAMD4DHRS9 ACOT11EDRF1 NANPHS3ST2 ZNF696LINC00908 CHST10ATXN1 WWC1LOC101926918 CBLL1AMT VSTM4

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RCL1 ZNF484TESC HBS1LGPR114 MYO6REM1 KRTAP5-AS1TTF2 IGFBPL1AATK IGF2-ASLOC101928104 THAP5C16orf54 MMP25-AS1SNX1 PI4K2BLOC101928626 ASPHLASP1 TOM1KIAA1109 ZNF503-AS2MNDA PREX2ZNF518B MICAL3SNORA74A ARMC1ST7-OT4 IFITM2MEIS3P1 PTPRGNPPB NXNGPC5 CPUXT CACNA1DHSD11B1L RFC1FAM46B ADGRA1LOC102724587 ERV3-1MIR6875 /// TRIP6 MAPK6LOC102724356 ETNK2LINC00881 FCF1P2C18orf54 WDR20NLRP8 LAIR1WDR6 BPNT1CHCHD5 GTF2A1GTF2H1 C12orf65MON2 CADM4FBXO30 OXSR1PLCH2 CD99ZWINT RABAC1C1QB OR7E14PC1orf213 PPP2R1AATXN10 CSRP2GPR137C RABGAP1LLINC01085 SCFD1ARL14 CLMNPOLR2J2 MSH6GYPC GLI2FDFT1 RAB37GOT2 SNX19ZBTB39 PCBP4EIF4A1 /// LOC101928634 /// SENP3-EIF4A1 /// SNORA48 /// SNORA67 /// SNORD10PIN1FNDC9 RNF8AP1M2 ITSN1CAPRIN1 TP53I11

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SPDL1 ZFP91MIR6732 /// ZC3H12AAPBA1CLCF1 CBFBLOC101927278 PGFLINC00700 ZNF506DTYMK ATL1GLP1R METTL22GRIPAP1 TDRD6PPP6R2 ITIH5GK HACL1DERL2 ANTXR1RARS2 PELI1PRMT1 SPEF1EFNB3 TRPV2WFDC1 KIF13BNUP62 SPATA13BTBD9 DNAJC19PAPSS2 RIMKLASELL C12orf75MAP1B TRRAPPKIB TGS1TXNL1 SELENOPCASC16 LRP5LMAP3K3 PRKCQ-AS1SLC8A3 MYO18AHIST1H3I TCF7L1CRYGD ZNF43LRRC40 FAM3AZNF24 GET1C12orf55 USF2LOC101926907 TOR1AIP2KIAA0408 CCR1LOC101060391 ANKS6MIB1 PRADC1STAM-AS1 TMEM126BLOC101927829 POM121L9PCRYBG3 INSM1LOC439911 STMN1C16orf3 PANK1PELP1 SSBP2METTL1 GJD3TMC8 RBCK1LSM10 UBR2NDUFV2-AS1 PEAR1CCDC12 ANKRD17DPP7 ZNF543RMND5A DHRS12KRT15 TCP11L2RP11-680C21.1 FRMD4BIFNA1 KLHL18

Page 123 of 781 Diabetes

IQCF3 /// IQCF4 RNASELNRAS TPM1MOK TRIM36GPR162 LINC01933DENND4C SRGAP2SEPT4 LRATD1EIF5 DZANK1C16orf93 HIST2H2BETMED8 ZNF766PIDD1 AQRITGB2 MYBL2DPY19L3 EXOC8LOC101926906 ZNF141TSPAN8 BCAMWDR74 BRI3RABEPK MRPL58EDNRA FSTL1LOC646762 SAMD9IGLL1 ANXA6ZNF28 POU2F2MGAT2 SRP19CHEK2 CYTH3KIAA2013 FAM204AZMAT5 CORO7LYPD1 SMG7-AS1YES1 ING5HDAC1 SIX4GGT7 DCP1ATRIM47 RTCACT45A1 /// CT45A2 /// CT45A3 /// CT45A4 /// CT45A5 /// CT45A6 /// LOC101060211 /// LOC102723631 /// LOC102723680 /// LOC102723737CEP97RBMS1 PCDHGB2NNT KIAA1755F7 ZNF763CXorf56 ARNTLKLHDC9 GFM2EIF1 LINC01770BCL9L CEBPZHK2 /// RP11-259N19.1MYO1BUGT2B15 TMEM8AROR2 RSPRY1PAX5 SMAD5C12orf54 C17orf113RAP2B SNAI1SNRK-AS1 RASSF8-AS1GOLIM4 GSDMBLOC101928553 ATP6V1G2FA2H RBM43PEX13 CD276FMR1 ALOX5APPAPD4 PCBP2

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BRE KAT7FAM83B EPN2CDH24 INPP4BC3AR1 HTATIP2MGC4859 TMEM140CAMK4 OR7E47PU2AF1 CCDC65HBG1 /// HBG2 PECRTMEM87B SRPX2NEDD9 STX7LOC80154 TBC1D8-AS1STX6 TM9SF4CDKN2B FBXL12LANCL3 C18orf21GNB2L1 /// SNORD95 /// SNORD96AFAHSNN POLHLOC401052 PPP6R2HDDC2 KIAA1324EPN3 TMEM231CCNG1 PHKA1TCAP RPP38ACTBP9 /// ACTBP9 CGNRPS12 ABCB9PAK2 ABCA2HADHB OPTNNPHP3 H2AFJUHRF2 CCDC6GPR135 LONRF1CREB3 SLC41A3AATF HNRNPDIGSF5 VCPIP1TTC27 UBAC2-AS1STX7 RRP8LONP1 DYNC2LI1USMG5 MED19EIF5A IFT172TBCK DGKBTTC38 ARHGDIAHSFX1 /// HSFX2 NR1H2PCSK2 GFERTNRC6A RASSF4CSMD3 ZNF789RPP25 DELE1SAV1 ST6GALNAC5GABARAPL1 /// GABARAPL3ACER3UBL7-AS1 C2orf68PALLD ZNRD1ASPLOC100129722 GLP1RRP11-157P1.4 C2orf16TMEM67 NAA10

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LOC100506100 CARHSP1BAZ2B ISM1GCLM EHD4MNT FGD6PITPNB TRAP1IWS1 ZDHHC5TPTEP1 S1PR3HAND1 SERPINE1UCP2 RTN4ROGFOD3 GRK5ITGA5 KCNJ16BIRC3 ZNF32AC005523.2 RNF208GRM5 PDE8BFOXL1 NINLC1orf112 GXYLT1TXNDC15 RGS12TMEM51 PLCG2PACSIN1 GMPR2LOC101928198 /// MFAP3LFBXW5GUSBP5 PDE4CACTB RAB5BLOC101928789 /// SP140MORN4SLC22A3 ADRB2KIF20B NDUFB1ZDHHC8P1 MAPRE1DIS3L2 GDPD1NLRP3 NOL10CPVL RMND5AKDM5D TIMM50WDR60 MTUS1ATP6V1C2 CLK3CTC-338M12.4 PABPC4PIGZ CUL4ANMT1 LINC00473STMN4 MMS19ZCCHC10 BOLA2BTNFRSF11B ZNF366MIR4680 /// PDCD4 NOB1CD8B /// LOC100996919NT5C2C2orf72 C3orf67INSL6 ATP6V0D1AXIN2 ZNF589KRBOX1 PLEKHO2DDX19A SNX17TPSB2 PSMD6WIPF2 PDZK1GJA9 /// GJA9-MYCBP /// MYCBPTBCEPTGER1 LMO2LY86 MAGEE1

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RCAN1 RAB26SLC16A1 AAASSLITRK1 TESK2TRIM71 GSTA2PPWD1 ZFP28LMOD1 LOC100049716KIF26B ZDHHC24MPZL1 NID2INPP5E PPIAL4ABTG2 CNN3HLA-DRB6 SLC25A28EGLN3 STAT5BMYOT RASGRP1APOBEC3B RGS7BPCNTNAP3 /// CNTNAP3B /// CNTNAP3P2MPPE1SRSF12 MAN1A1MSL2 TSPAN11CPSF1 /// MIR1234 /// MIR6849 /// MIR939GTF2IP1TOMM40 YPEL2HMBS GRID2IPND2 ITGA8MIRLET7DHG C19orf44CALB1 PRKD2LOC101929761 ZNF561SLAMF6 MRPL35TBKBP1 ROR1-AS1COX6A1 PFKPSCAF1 DGUOKNAT1 LARP6CBLN3 GATAD1TMEM2 LOC102725021KLC4 VSNL1AURKAPS1 /// RAB3GAP2TUT4SEMA5B TAF8MXD1 EIF2B5RP11-384P7.7 KIRREL1SLC35E3 ADCY2RASSF4 THG1LKIAA1522 TMED6CDC42EP3 KDM6AZNF207 CORO2AKIAA0907 DPP9-AS1VPS52 ZNF420DHODH STX8RP11-307O13.1 LIMK1EDF1 ELOVL6ACAT1 MAST4NFU1 PDGFBSLCO2A1 GLYR1ALG14 ORC5

Page 127 of 781 Diabetes

LOC100130357 SLC44A2SLC35A4 LOC100288203PGK1 HYAL3NMD3 SLC35G1ZNF514 LOC441204KCNK6 GINS2RP11-692P14.1 PLA2G7TMEM175 CDH11NLRC5 C19orf25SLC35F2 TECPR2RBBP5 MST1LRASGRP3 TMEM30ALOC100505902 /// LOC285389MGAT4ASEZ6L2 ADRA2ATMCO1 KLHL29HKDC1 AP1ARLOC101928927 /// SNHG15 /// SNORA9PKNOX2IP6K2 TMPO-AS1PDZD7 ABT1BC017398 /// CTD-2314B22.3 /// DQ786293 /// DUXAP10 /// LL22NC03-N64E9.1DCAF11SLC17A2 ZNF497LINC00343 MYH14AGPAT4-IT1 PKD2MKS1 ISYNA1SNRPG CDC42EP3FBXO25 PCDHGA11YIPF6 ZNF875LOC100996654 PUF60TMEM30B SRPXEGFR HCFC1R1LOC93463 FAT3PLEKHO1 CASC15GLE1 SLCO2B1COX7C KATNAL1ABCB1 RBPJCLTCL1 FZD5SIRPB1 IER5LZNF182 FAM222AIL32 AGGF1ZBTB47 MSANTD4TCERG1L GHDCMIR6824 /// SLC26A6FNIP2ASIC2 FLNB-AS1TERF1 CCNDBP1MGAT5 KIAA0753C3orf14 ZNF81IL4R SSRP1FAM13A-AS1 SMIM10L2BSLC43A2 CCDC68LINC00665 ZNF773

Page 128 of 781Diabetes

SHISA7 STK33CPA4 CHST4PSMB9 GSTM2FCGR2A RNASET2FLJ43315 /// LOC101927088 /// LOC101927527 /// LOC101929518 /// LOC442028NEK1LILRB2 H19TOM1L2 SND1SYNDIG1L GABPB1-IT1RP11-395I6.3 GALNT10P2RX2 H2AFY2WDFY1 CEP170BRANBP2 /// RGPD1 /// RGPD2 /// RGPD3 /// RGPD4 /// RGPD5 /// RGPD6 /// RGPD8E4F1LINC01021 CLDN5ROMO1 PARTICLFAM210B SFXN5GJA5 HPCALOC101927253 MARF1SPRYD3 CASP1SUGP2 NHSL2CAV2 USP6NLTRIM31 BIN1ENTPD5 TOM1L1RAD23A ZWINTZNF428 ZNF213SEPW1 CSNK1EDUXAP10 YEATS2-AS1LDHC C1QBAK022030 /// TROVE2TMSB4XAIF1L CYP39A1E2F1 ZNF487LDHB POLIFAM120AOS DCAF17RIT2 ENAHANKRD2 LOC101928174TMEM80 HMOX1FTH1P5 PIGOPRICKLE2-AS3 CAMK2BHMGCR F3ITPR1-AS1 B3GALT2GPX8 CLSTN1BCKDHB TM4SF18ALDH1A2 /// LOC101928635MFSD4BCTD-3092A11.2 THRAHLA-DQB1 /// HLA-DRB1 /// HLA-DRB3 /// HLA-DRB4 /// LOC100996809 /// LOC101060835LPP-AS2HABP2 MDH2HPCAL1 SNHG17HHIP GAB2FUS ZNF337FGF19 SLC25A20CTD-2555O16.4 /// MTHFD1BNIP1

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SHMT2 SLMAPRHNO1 ZNF814ARL5B MIGA2WBP1L SMAD6PARL NOL4SHCBP1 SLC9A3R1RP11-49K24.4 RSU1LOC102723918 TOMM40LEMC2 MAPK10DNAH12 DIDO1ZNF821 SEMA3GKANSL1 CCNA1RXRA MIS18ATTC39C LOC100130992BRCA1 NUP153GJB2 PBX3SETD3 KANSL1LPDK3 LMBRD2CASP7 FAM89BKRT76 SLC43A2KRT18P50 /// KRT18P50RAB19LOC148709 SNCAIPRETN ZC3H11APCDH19 AGAP1DNAJB6 SNRPCMAP2 ITGB3PLAC8 HAX1FBLIM1 SEC62SUPT20H ZNF707TARP /// TRGC2 /// TRGV9VPS16RBM27 HPCAL1GAB3 FAUMAPK6 SH3TC1IQCK ZBTB16BHMT2 GJA4CCRL2 ADHFE1PTBP3 BIN3GALNT1 SMOGALNT4 /// POC1B-GALNT4RNF122STK3 ARL15DYNLL1-AS1 NRP2C14orf166 RPAP3SSBP3-AS1 WNK1IGSF3 HES6OR3A1 SLC7A11PAQR5 AP3B1CCDC104 WTAPRDH8 NWD1DOCK2 CMTM3DNHD1 LETMD1

Page 130 of 781Diabetes

FOXN2 ELMOD2LOC153577 ASS1HSPA9 PFKFB2ORAI1 ZNF792NDUFA2 IGBP1CHID1 STARD8LPIN2 NTNG2SPATA6L CYP2T1PRP11-846E15.2 CCDC74ARP11-66N11.7 LOC100507599SNTG2 TNFSF12PHF7 SNAI2KRR1 GAB1MS4A14 CREBZFGNPNAT1 ALG1FLJ31306 SH2B3NOB1 FMODDGCR14 ANAPC10RP11-1277A3.1 MOCOSLOC731424 THADAGFPT1 UQCRFS1ND3 /// SH3KBP1 ZNF652LAT2 SULT1B1CDC42EP1 C5orf30RIN2 C1orf122LOC100127974 PGPGLCCI1 CFTRSMC1A FAM98BPRKAR2A FUT1LIMK1 CASC3UNC80 PRPH2NT5DC4 ATP5F1CSH3GLB1 MRLNHLA-A MOB3CCHCHD4 CIR1PLAA COMMD4SPTSSA CDAN1ABCB8 /// ASIC3 GREB1MS4A6A RPS6KA4PVRL1 ASXL2CTTNBP2NL ONECUT2LOC100129361 UBQLN1ALYREF CYS1CYFIP2 COL22A1PAN3 TTI2RP11-18I14.11 NIBAN1TP53I13 FN3KRPCSNK2A1 /// NFE2L2 SERPINB8GDAP1L1 DDX59NLN PIP5K1C

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MTPN ECHDC2CCDC68 FKBP4APEX2 PTGES2RRP1 RNF224DLD DPF1OGFOD2 ID1NFE2L2 NYAP2LOC101928747 /// RBMX /// SNORD61EDEM3AF186192.1 ARHGAP12CCDC181 DDX11CYP2E1 CCL28LYG1 PDCD4PRICKLE1 GSTO2IL15RA LSM7FBN2 R3HDM1ECM2 LOC100130111RNF150 PFKFB3ZCCHC4 FIZ1FAM58A NOL11HSP90AA1 CHKBLOC101928401 NCOA5PRCP KCNMA1RP11-339B21.15 KLHL21TCTN2 QTRT2CLEC7A ZNF777TIAM1 MAML2HYAL3 GPSM3TIRAP ADAMTSL1PHGR1 SWAP70MGC12488 MTMR1NID2 CD3EAPSLC8A1 CYYR1C1QTNF7 CRELD1DUT RWDD3TACSTD2 SCAF11GABPB1 WDR62SRSF6 CISHCXCL14 GPATCH2LMSANTD3-TMEFF1 /// TMEFF1PABPC1ATG3 THAP1RAB40C ENKD1B4GALT7 CDKN3PRRG1 PLEKHM2LOC220729 /// SDHA /// SDHAP1 /// SDHAP2LOC100129434JSRP1 ALG9XXYLT1 ZDHHC9GVQW1 C9orf40CXCL2 FAM124ADUSP4 LPCAT4HIBCH LOC285074

Page 132 of 781Diabetes

ZNF570 PGGT1BPCYT2 LRRFIP2EAF1 HARSSNX7 SLC38A1SLC5A9 RAB3DLOC400684 FGD3PPP2R2A RIOK3CDK13 COPS6S100A12 RBM7OTUB2 BBS4C9orf156 PCDHGB5FGF2 DAPSF3A1 FASTKD2NDST4 CD320KDELR2 A2MLOC101928784 FUT11LMO2 ZNF800TMEM47 EME2SLC44A1 LOC101928303COPB1 CSTF1DDC-AS1 LINC02615SETMAR FKBP11LOC100507351 HDAC3RASSF8 BBS7RP11-263K19.4 CRISPLD2FAM160A1 STAP2VCL SCRT1CXADR PREPLPRKCQ-AS1 ATAD1GTF2A1 EBF1CD81 FAM86DPANKRD36BP2 PRORPLRRC41 IGSF10DUSP12 TOE1RAVER2 SNRK-AS1ZIK1 DHX33GAL3ST4 PDGFDUBE2F CH17-340M24.3CTAGE15 /// CTAGE4 /// CTAGE8 /// CTAGE9LOC100129617SHC2 PCOLCESUN3 CNTN4CTD-2520I13.1 PLA2G15LINC00520 ZNF516SLC35E2 /// SLC35E2BMPLGOLGA7B CNOT6EME1 IFITM3HEBP1 PARP11PREX2 LINC00643LOC101928335 PIGGSUSD4 MTMR11

Page 133 of 781 Diabetes

AGPAT9 PPP2R1BIBA57 PANX2MAD2L1BP SNF8RFX2 LINC01091PSMG3-AS1 RCE1RARS CFAP43SH2D5 ZNF93NRG3 MEIS3P1MCPH1 CSGALNACT1WNT7A NLGN1PTDSS2 GPR162SLIT3 EIF2AK3-DTLRFN2 RAB2BLOC102723390 AK3EDAR ACSS1MTM1 SDHDLOC100310756 PTK2BRBM41 CCDC90BBLM RPS6KA5GRAMD2 SLC45A4C15orf59 SNRNP200ANKS3 STARD3NLMCM8 IFT81ABI2 IDH3BBAK1 VMACFAM60A CCNB1IP1IRF9 BCO2FEV CADLOC102724809 CCT6P1USH1C ENY2CYHR1 ACOT4KCTD9 PSPC1MPHOSPH9 LINC00680C6orf141 CXCL12PNO1 ZNF658APOPT1 PGM1PIGF TMEM196CTAGE1 IPO11CDKN2AIP TSC1LOC100996412 SMC1AELOVL2 BROXSOCS6 AGTPBP1EDARADD EDNRAARHGAP35 SAMD13KRTAP4-4 LOC105372633SEPT7P9 FRAS1IFFO2 AS3MTPLCG1-AS1 ZNF134IL4I1 CA8PUSL1 CCDC3

Page 134 of 781Diabetes

ZNF519 NDC1LMCD1 PHF23FAF1 EIF4G1SPATA7 SAMD4BLOC101928907 LOC100129534GRAMD1C ZNF736CAPNS1 FAM86C1FAM71E1 DMGDHCRABP1 ANPEPCLCC1 RFESDZER1 TBX6DPY19L2 LOC101929532SIAH2 LRRC9LOC100131510 EIF3DRP11-403P17.4 TRPM6PARP10 ERCC2ABL2 ANKMY2AGPAT4 NAV2LA16c-358B7.3 TRAPPC4POLI IPO7CEACAM6 RANBP9UPK3A GPR158-AS1AC090627.1 MDKLOC101927330 PARP6CXCL5 CITSTEAP1B NPTX2CIRH1A LGI2LOC338667 MRPS25BC045560 PAPPA-AS1ATG4D ANO1SLC25A46 CACNG4LOC100996286 RNF215KIAA0125 EXT2LINC00092 COLCA2IL1A CLASRPDPYS CCNI2SERPINB7 FAAP24ODF4 CTNND2F10 EHMT2NAT8L ZNF764DFNB59 GATD3BTRPV2 TPM1-ASPABPC1 ZNF519MAN2A1 CFIAKIP1 /// NUAK2 ZNF365RNF207 ZNF33ANOS1AP CRLF1RP11-804H8.6 RRN3P1AA06 PLPP6STK4-AS1 OTULIN

Page 135 of 781 Diabetes

UBE2D3 PTPDC1MICAL2 LPIN3SEC61G LUMRPL31 ADAM33NOXA1 PATZ1NPIPB15 LOC257396PTRHD1 ADAMTS14NCEH1 TMED7LINC00958 MOCS2EZR CLEC2BZACN FAM110ARP11-495K9.5 SEC14L2LOC286367 HLA-DRB1CASP4 ZC3H7BPRUNE CD53ATP8A1 SLC3A1TRIM69 HRFLJ25917 SHLD3ENAM GMFGFAM69A PAXIP1-AS2EPHX1 ZFYVE21LOC100130691 ZCCHC9MMS19 RBP5SLC30A7 ADAC6orf223 PRCPPHEX-AS1 ACOT13KRT18P38 /// KRT18P38DVL1LOC399884 GRID1C15orf57 TAF9LOC101927623 LINC01050MIR670HG MTMR14CD81-AS1 TYROBPCT62 LOC101409256HSPB1 EHD1CDK12 GDAP1L1NDUFB7 LINC00870LAMC2 SOCS1BTF3P13 /// BTF3P13 MRPL33RP5-1085F17.3 GATD3ARCAN2 PAK3CD3D FAM214BNALCN SLC25A5-AS1ELOVL6 SNRPB2WSB1 SNRPA1RAD9A ADSLCTNND2 TRA2ATHSD4 DLL1DSCC1 SHEXCL1 /// XCL2 DDOSTIL24 CTNNBIP1

Page 136 of 781Diabetes

LOC102724640 PRUNE2VARS SPARCPSMD3 HHLA3TKTL1 NUDCD3DSG2 TANC1NDUFAF5 PPARGC1APOGZ HLA-ARP11-395B7.7 PLAAT4IKBIP BCCIPGABRQ TMEM160C1QC METRNHLA-DQB1 /// HLA-DRB1 /// HLA-DRB4 /// HLA-DRB5 /// LOC100996809 /// LOC101060835MTFP1GABRA5 SLC8A2LINC00029 SMIM26NRTN ABHD11DGKQ HS3ST2ARHGAP11A GPR146ARHGAP15 /// LOC101928361SERPINA6KRT79 CFAP221RP4-635E18.8 LEPROTLGALS8 FHL3LOC101927537 OLFM4GUSBP3 /// SMA4 /// SMA5SNHG10ANKRD33B MED28SPR VAMP7KRIT1 LRRN2C11orf1 B3GNT9LSM4 PPP4R1MPHOSPH8 BIRC6RNF151 IDELSG1 CROCCP3CFL2 MXRA8RAD51AP1 CARD10RRAS LOC400940LOC101928504 SH3RF1EIF3E TP53I3ACOT4 SUMO3AMDHD2 /// CEMP1 ZNF737CTNNAL1 TENT4AOSBP GPBP1L1LINC00865 TAF5LSLCO2B1 MIR1915HGRUFY3 TRMT9BMGC50722 DNAJB7LOC100506563 PDPRATP6V0B EPS8L2RP11-82L18.2 DPY19L3ZFR TUBGCP6DIP2A ATP8A1ANKFN1 /// BC037494CACNA2D1

Page 137 of 781 Diabetes

SPATS2L ZNF559-ZNF177NPSR1-AS1 IQCEDPH6-AS1 PCDHB8CLEC12A SOCS3ABCA2 PLA2R1RASA3 POLR2LSTAG3 LIFR-AS1HTR3A NRG2LINC00632 ST8SIA3RPE LARGE2JKAMP LINC01564SEC61A2 PROX1-AS1TP53BP1 CENPHIL21R-AS1 CCDC85ALOC100506699 GABARAPL1UBE2M COQ4PRR11 SAMD14USP35 DLG5-AS1ZFAT APOBEC2DYM POLR1CLOC400043 ARHGEF6CNPY4 PFN2FKBP1B PCK1VLDLR SHISA7ICMT SPINT1-AS1LCN6 CD302RPS3 UBR4AF001548.5 FFAR1MYF5 SRGAP1DHRS12 COX6CTLR8 PCYOX1MDH1B GLDCIL6 GNAQIFIH1 RNF114CYCSP33 /// CYCSP33 GTF2IP4BDKRB1 MTMR4MTPAP ZBTB47FRMPD3 LOC101927911TRA2A SPCS3TPSAB1 /// TPSB2 ASIC3MTA2 LOC105369147MAPK10 CHN2TRIT1 CNOT7NUPL1 LINC00346ADORA2A-AS1 TMEM240NDUFB10 EVA1BUSP2-AS1 SLC25A25-AS1ATP8A2 SERAC1PGAP3 PARP10UBE2I SHROOM2

Page 138 of 781Diabetes

LINC01141 RCC2TST TDP1PLA2G4A FGF14RP11-483I13.5 ZNF426-DTNHEG1 SYF2XRN1 TRIM41C20orf96 NAMPTATP5A1 RBPMS2MIR6872 /// SEMA3B CAPN15RRP36 ZNF821SMARCC1 HLA-DRAAPCDD1 /// LOC100130468ANKRA2MEGF8 PTSB3GNT2 LINC00884FHL2 ACOX2RPS11 /// SNORD35B WBP2CCDC135 DHTKD1TRAFD1 EXT1PGM2 ITGB2SESTD1 NDRG3TMEM72-AS1 UBE2MP1BLZF1 BCL7APLK2 RCBTB2EBF3 FFAR2CAND1 MRTO4MSC UBE2Q2P1CALN1 GRIN2CLTK ARMH3RYR2 YTHDF3ICAM1 EFCC1PLK4 SLC7A4LINC00312 HTRA3CLUHP3 LOC100289361GGACT ZNF350HAUS5 RCAN3ASNTS RPL14MAT2B CD163DNAJC22 C1QTNF3-AMACRZNF204P SF3B2LINC01023 MFSD6LCCNB2 UCK2ANO10 ZNF496LRRN1 CTXN1PRR15 LIMS2MEOX2 TMEM255AHDAC10 GRIA3STARD3 TMEM94ARHGEF2 ORC6UBR7 PRR11SSTR5-AS1 ARHGEF26

Page 139 of 781 Diabetes

C19orf60 SNX18HEPACAM2 ZNF219ADCYAP1 KRBA2ZBTB40 RPS6KA2UIMC1 UBL3PPP3R1 DBF4KLB ERO1BSSR4 MOSPD2CA5B KPNA6FAM135B MBOAT7DCP1B HNRNPRNUDCD2 FBXL17ARRDC3 FBXW11PTBP2 ABCC4SLC27A2 HLA-JZBED6 ANGPT2TBX1 LINC00342ACVR2B-AS1 PRRX1PROM1 LGR4NRCAM SNHG12DQ570835 NNMTRAP2C GTF2BHIST1H4H NCK2CAPN5 ICE2TMEM71 GLRA3SNRNP48 SRCIN1PSMD4 RGS9LCE2B MIR29B2CHGHOTAIRM1 TYW5POM121L10P /// POM121L8P /// POM121L9PUBE2G2FNBP4 CMPK2DDX20 JAK3LRRC57 KIAA0825PLAUR LINC01146CRISPLD1 TUG1CREB5 /// LOC401317 CCDC121NUDT21 XPNPEP1BLOC1S1 PCDHGA2LOC100128840 KCNN3ADRBK1 FAM126AYTHDF3 RNGTTDPY19L2P2 EIF2S3BDTX3 ULK3PPM1B EML3LZTS3 BTBD18SMOC2 PXNLOC146513 SNX9DZIP1 FAM76BPOLR1D DOK1MYOZ1 GATD1

Page 140 of 781Diabetes

LOC285812 ANXA5SUSD1 OXSMZNF320 SPARCL1COL5A3 FOXF1MAPK11 MKI67LHFPL4 BARD1LINC01354 C1orf220COLCA2 EMC9LOC101929180 ANXA9ASF1A TSTD1CLDN2 PAFAH1B2SLC38A10 OSGEPMALAT1 PRKCILRRC66 CFC1BCACHD1 CCDC18SPRY2 GGNCYP26B1 ACTN4PARD3-AS1 ZDHHC16EFNB2 FAM86C2PHYAL1 POSTNSLC30A9 CRIP1MUC13 CDC25AARNTL NSD1FRMPD2 /// FRMPD2P1 /// LOC101930006LINC01547GPN1 ABCC6HMGB1 JAZF1RNF187 IL27RALOC100288893 TMEM51-AS1LOC101929747 GSTM2P1UBASH3B HEG1GON4L GATA4SLC6A14 UBR1LL0XNC01-116E7.2 ZBTB41ARHGAP4 STAMBPL1LINC00470 TRIP13ZNF543 TMEM223LOC401220 DFFALOC101927653 POLR3CKAT8 GABPB2GPRIN3 TNKS2SNRK HAT1MUC1 CYSRT1TTTY10 CALM2CERS2 PPP3R1PRKCA LARP4BSCAF8 IMMTRP11-329B9.5 ANKMY1FREM1 FLIISCN1A RRP9RP11-502N13.2 ERMN

Page 141 of 781 Diabetes

DNAJB5 ARSAHOOK2 SASH3SHOC2 DUSP9ACOT8 LRRC75BFAM201B /// LOC648761WSCD1MCHR2-AS1 PCNALOC100507480 POM121CMTMR12 NFAM1ACAN LEMD3ITIH4 KIRREL3LOC728743 /// ZNF775FANCD2MILR1 SUPT3HLILRB3 CGRRF1IGLON5 KLHL3DQ583756 MGAT4BDENND6B NCOA7DDX52 NUMA1LOC101928963 TMEM74LOC728061 MTHFRHIPK1-AS1 CCDC130ABCA9 BRWD1-AS2TDP1 DRD2RNF11 LOC100287497LINC00899 NOX4BLOC1S1-RDH5 /// RDH5GAMTTTLL11 KCTD14RPS10 RPAP2TMEM177 TFE3TNN A1BG-AS1RALY-AS1 TUBB3CRYGS EIF4ENIF1CHMP4C WACNFKB1 STX3MYCNOS KPNA1ELF4 ALDH3A2RORC ZFYVE9BICC1 ALG6SSBP3 CYP27B1ZXDA TCERG1LEFNA4 PIM3ANKLE1 CYB5R3RP5-1118D24.2 C2orf42MYO1B ZNF709CPSF3L /// MIR6727 SNAP29C16orf92 ASMTLCDCA2 GIMAP8LOC283177 GID8ALDH1A2 CMBLHTR1D MICALL1FASTKD3 IL17RB

Page 142 of 781Diabetes

ALG13 CSPP1ANKRD37 SGMS2DBNDD2 /// SYS1 /// SYS1-DBNDD2BIRC2LOC101927815 C21orf58SLC31A1 FAM86B1SIM2 ACDCRY2 LINC01014MLEC PKD1KITLG 1-MarFLNA CBLBKMO GCLCPCSK4 KIF1BPC18orf61 WASHC4LL0XNC01-7P3.1 SIGLEC16OGFRL1 BZW1OAS3 ACTN1SSX2 /// SSX2B HRKWDR45 MAP3K9PGLYRP2 CKAP4GYPA ID2-AS1DBNDD1 MANBALNX1 QDPRTNF TBX3PRPF4B TCN1IKBKB EIF5A2ZNF134 TMCC1RPH3A PTGS2EPHX4 PON1DSCAM PPP6CNR4A1 STEAP1MOAP1 INSYN1DRAM1 TEAD4MDFI LOC100507507XCL1 TMEM183AKIAA0247 SIGLEC15TPGS2 FOXD2-AS1HIST1H2BL NLGN4XZNF503-AS2 CAPN13EXOSC2 ATRNLHX1 HMGN2P46LOC101927592 KIF5BNDUFA13 BTBD11FOXP4 PRDM16CUTC ULBP3SSRP1 TSHRMMD RNF19BHK1 CSF1TTC13 RHEBTREM2 CYP7B1SRY RNF150

Page 143 of 781 Diabetes

RP11-669C19.1 KLHDC9HNRNPA3 /// HNRNPA3P1CTNNB1LOC100131170 LOC100507564RAB11FIP3 PRKAG1TUBB6 KCNK12LOC441601 APLNSFT2D3 EIF2AK4GAB1 SLC9A1LOC100131756 NCBP3SCUBE3 XPO4CMC4 /// MTCP1 SSH3FAM84A /// LOC653602LINC01123SLC38A1 STX17ICOS FBXW9HMGB3 PDCD10AVEN AHSA2PPNMT RBM4BS100A11P1 /// S100A11P1RPARP-AS1LAMA2 ZNF626TCERG1 FAT4SMA4 FADS1ADIPOR2 CCR6ADPRH C1QTNF3RANBP1 C17orf49CXCR2 PCDHGC5SNX5 RNLSSYT12 SCARF1RP11-73M18.8 ANKRD22C16orf87 CYP1B1FCRL5 RIPOR1KIFC3 AKIRIN1FOXH1 ST3GAL4FAM153A /// FAM153B /// LOC100507387 /// LOC102725213SEC11CIMP4 ARHGAP31IMPAD1 PLPP4SLC1A5 IPMKCCT6B TM9SF1SIRT1 PYURFLOC101927044 GPATCH8LINGO1 ZDHHC11BBC044765 /// RP11-96B5.4MCF2L-AS1ABCC9 MAMLD1MGLL TRIM59PTPRR ARNT2TWF2 MEDAGSLC39A1 NAIPHOXB1 GNMTSLC4A3 CZ1P-ASNSBCL2L12 CLGNAK2 SMG1P2

Page 144 of 781Diabetes

WDR41 GPNMBACAD8 FAM53BTNS4 FBXO45AJUBA MTRMGC24103 GGA1PLCG1 RAB14RNF43 SLC2A2AK024134 /// PPM1H GNB5MADCAM1 CDH2ERH PDAP1UHMK1 PCDHB12RP4-794H19.1 PSRC1THSD7B SERPINB1MMEL1 SRSF5PANK4 MFGE8MAP7D3 ENTPD6U47924.29 ADCY4GUCA2B CAMK2N1KCNT2 NXPE3UQCRB ZNF287MYO1F BUD13WDR34 HOXB7BCAS1 METTL2ASIGLEC10 ZADH2FMNL1 GLRX2TMEM61 UBDLOC100272217 VEGFCMIR6748 /// TMEM179BRAB8AB3GALTL ACKR3DUSP5 ATP1B2ZDHHC12 ADGRG5ZNF229 EXPH5GOLGA8I /// GOLGA8MGADD45APBX3 HADHPABPC3 VIPAS39GLYATL1 TXNCDS1 FAM24BSLC2A4RG TBCBMKL1 SUCLG2TBC1D16 DPM3LRRC36 P4HA3LINC01191 GLO1TCHP GSPT2S100A3 ZNF236ANKEF1 ZBTB2FAM83E ADTRPZFP36 DCKSPATA41 AKR7A2CCR5 NETO2DCAF11 DEPP1

Page 145 of 781 Diabetes

RNASEH1-AS1 RAVER2DGCR5 SS18HBA1 /// HBA2 ZNF597ZNF177 /// ZNF559-ZNF177NOL4LASPA GALNT2RP11-138A9.1 SPARTPPIL6 SLC39A6RNF141 PMM1EIF4EBP2 PDK3NAA11 CTAGE11PCHORDC1 MISP3EI24 LOC100134368PDHA2 PNPLA5CDKN2D OSCP1LINC00877 S100PBPRP1-228H13.5 LOC645513MGAM CCDC74BPRPF40A FAM111BGSTO2 UCKL1-AS1CCDC9 FBH1ARSB FKBP9P1BHLHE23 ESDRP1-6P5.2 LDAHPP2672 MEAK7DGKB NUDT14CRTAP LOC105371485TXLNB TMEM271TULP2 SLX1A-SULT1A3FRAT2 SLX1B-SULT1A4ARHGAP31 WBP11ST3GAL1 GNAZKIAA1549L CRLF3SDR42E1 GJB1SETDB1 LOC101928728MRAS LDOC1PRDX3 LOC100130872DESI1 KLHL23SFT2D2 HDDC2GTPBP8 UNC45AUBIAD1 NELL2NMUR1 DSPSLC35F1 DYNLRB1CACNB1 C8orf58SYNPO TIMM23BSVIL PCGF3DPY19L2P4 FAM120BCFHR3 SMAGPMETTL4 AP1S3CDR2L ZNRF3PKDCC SNORC

Page 146 of 781Diabetes

LOC102724364 /// SEC22BSUV39H1FHDC1 FAM24B-CUZD1RCC2 LINC01886TSEN54 SERTAD3BC042825 /// RP1-179N16.6PINX1TLCD2 MROZNF780B MYL9EIF3B TSG101RABGAP1L TNIKOR2A4 ZNF571DAZL VAMP1PRPF19 KMT5ARSPRY1 AXIN2SERF1A /// SERF1B SLC22A15DUOX1 FZD7SLC8A1-AS1 ALMS1-IT1MAP3K13 ATL3KLHL7 NPLOC4VPS37B CCDC141CASC5 NUCB2KCNA3 HEPHMIR6805 /// RPL28 SLC12A9MICA /// MICB TMEM9BLOC100506713 FAXDC2LINC01278 TTC9LOC100287497 KMT2ARP4-593H12.1 ACVR1CPDZD4 BANK1PRO2964 HID1ARHGDIA CYBC1DHRS4-AS1 SEMA4CBBIP1 PRPF40ALOC101926975 ASCL1ZNF84 L1TD1ST8SIA1 SGIP1CD79A NFKB2RTN4R HELZTMEM102 EMBSERPINF1 SALL1RNASE6 MRPS26FAM27E2 /// FAM27E3PEX11AVEZF1 CAMSAP3MAD2L2 CASZ1MCM3AP MED17ACTR10 ILKFIS1 SMOC1RAP2A MGMTKHDC1 REG3ALZTS2 QSOX2MORC2-AS1 USH1C

Page 147 of 781 Diabetes

RP11-67L3.4 SENP1GLIPR2 DNLZFLJ13744 GLRXRD3 SVBPATRN SHFLISOC2 MKXLRTOMT ENPP1SGPP1 LIMS3TNFAIP8 TXNRD3RAB7B GRAP2ZNF442 HNF1BPGAM2 CCDC14SHC3 FLVCR1-DTCLCNKB UACACSMD2 ELF3-AS1NAPRT SURF4ASB16-AS1 DAAM1ADM PQBP1SLC9A7 SMG7MS4A3 TMEM187LOC101929709 SUMO1CCDC130 SETD5CLDN1 LOC100506302OR1A2 ABRACLCYP4F2 PDLIM2PGS1 EGLN3PVRIG CAP2SLC35C1 TYK2LY6H CT75LOXL1-AS1 CHAC2VAMP4 MBTPS1UBBP1 /// UBBP1 /// UBBP4 /// UBBP4SLC25A13SLC7A1 KRT222LOC101929864 /// SLX1A /// SLX1BBEX2ADAM12 SPDYE5ARMC7 LOC101927495SCAND2P PLLPTRAF5 TTC7BTRMT112 PACS2SPIRE1 EML4ZNF175 MPDZRNF139-AS1 INIPRPLP0 AFAP1L1HIST1H2BA SEPTIN6CCDC105 ZNF142NWD2 TMED1DPYD ANKRD50LOC285957 ANKS1BTMEM239 PIP4K2CGFM1 UBE2G1

Page 148 of 781Diabetes

CITED2 LOC102724135IL19 THYN1TMCO3 C2orf76CCL27 N4BP3TAF5 PREPADNP2 NUDT18MINOS1 MTERF2C6orf226 AGAP3KRTAP1-1 RPAP1PDXK GUSBP3FLRT2 /// LOC100506718 /// LOC102724348OAZ1RPS10L LAMC3ACTR5 MSMBFGD2 PLXNA4FUT3 CNOT6LRPS6KA3 CCNL1AK098263 CARFH2BFS FBRSL1C5orf47 ACRLOC100506207 LINC01503CCDC42B YY1AP1RAB11FIP1 ALDH1B1UBXN10-AS1 MOCS3GEM XXYLT1LINC00606 BRAFKIAA1614 LGI3NT5C LOC644554ASGR1 MOSMOZNF541 OTUD4GNA11 GNESLMO1 NOVA1ZNF671 POU6F1HOXB-AS1 KIF24SLC25A12 CHORDC1ALB LOC114841035WNT11 RGL1HLA-DQB1 /// LOC101060835PPP1R14ALCK SRRM2ECT2 PAPOLGGPC1 TUBB2ASLU7 SULT1C4RMDN2 KIF27UGT1A1 /// UGT1A10 /// UGT1A4 /// UGT1A6 /// UGT1A8 /// UGT1A9POLR3GUSP32 /// USP6 FAM174AGPR39 C1RCOL9A3 GRHL3LOC145474 HTD2ABCC1 PCSK7KIAA0485 C2CD3CLASRP DROSHA

Page 149 of 781 Diabetes

AL833181 ATP6V1G1R3HDM4 APCDD1UBE2B ACOX1PAK6 CAND2SFXN3 SMIM2-AS1C10orf25 PSEN2RELL2 PPP1R12BZNF765 YTHDC1VEZT GS1-124K5.11CCDC142 HCG11AKR1C4 GTF3C2KRT10 ZFAND4CHSY1 ASPNRP11-714L20.1 NR2F1-AS1ROGDI SNX29KHDRBS3 LZICLOC101926915 TIMM29GJA1 CLDN12SDSL IGSF22CCND1 OXLD1VPS8 FOXO3LMAN1 ZNF563SLC12A7 ZNF157PDDC1 WIPF1FBF1 KRT40SLC17A5 SSBRP1-223E5.4 /// SIRT5TBC1D20FAM132B TMEM179BNDFIP2 SLC36A4ZNF512 MSH5-SAPCD1SLC6A4 NKIRAS1MYL7 NIF3L1SMARCA4 DACT2PRDM16 PCDHB2MAPK7 LINC01612RP1-130G2.1 MBOAT2KIF2C C19orf48NUDT19 APOBRAPCDD1L RAB11FIP2MGST3 GALNT3MAGT1 SSR2MTHFS /// ST20-MTHFSMYO3ASLC7A11-AS1 ARMC7LOC100505938 MLXIPLC10orf55 SEPTIN5CARTPT ANKLE2SYT17 MMP11AOAH LAMTOR5CD8A RNASEH1-AS1SCRN3 TCEAL4

Page 150 of 781Diabetes

S100A10 FAM114A2FKBP4 LRRC61PEX16 PTGR1MLXIPL ROR1KLHL12 TPM2LOC101928014 SAPCD1-AS1ZNF711 HMGXB4LOC344887 G3BP2MITF HDAC6AURKB SLC15A4PPY2 C15orf65ITCH SASH1PSMD6-AS2 CCDC58ZNF684 GSTM5ADM2 EDIL3SLC41A2 LINC00865CYB561D2 AGO4CRB2 ACTG1DLEU2 /// MIR15A KIF7PSTPIP1 NR5A2ICAM5 IL1R1MAP4 RN7SL832PLOC101929745 MTCH1LRRK2 INO80B-WBP1LOC338620 HCG26CDCA5 TACC2SENP2 SYNMHCG8 /// ZNRD1-AS1 SYNRGLACC1 LRRC4BAGAP3 OTUD3BC062753 MIR4453HGPTPRK B3GNT10MTF2 FKBP8NLK PIK3IP1FXN ZBTB8AAGK AFAP1L2PLCB1 CD2BP2SPTBN1 RFXANKCRIPT FRMD8STARD13 CCT6P3CTD-2033C11.1 BMS1P4-AGAP5RHOC USP46DMPK TTC13KLHL35 ZNF256NAA16 HTR7P1SRP19 CCL26CD83 DCBLD1CDX2 ADMUSP9Y UBALD2HIST3H3 HAUS2

Page 151 of 781 Diabetes

SLC34A2 LOC105375304CCDC97 LOC100506990B3GALT5 MYL6ABCA11P SOS1SCART1 LIPHAC010980.2 /// LOC440934 /// LOC440934IQCGPDLIM7 AKR1C2LOC101929143 FGD1ATF3 APOLD1KIAA0196 GNB3PRKG1 NOL3CTD-2292M16.8 POLR2BZC3HAV1 NRXN1KRT14 LOC101928123LOC101929570 TRIM32MAFF ERI1AGER DTYMKSULT4A1 GUK1ACTR3 GATA6FBXO9 VSIRIFT122 /// LOC101927266FBXL7CALU HS3ST3B1MEX3C VWA5AOCRL RGS3GKAP1 WASC9orf3 MUS81SCAMP2 PPP1R36RP4-657D16.3 STMN2CD2BP2 IGF2ZNF226 SPNCDKN2C CACNA2D3B3GAT3 SH3BP5-AS1LOC101929076 GPC1SLC29A1 FAM171A2PLEKHN1 SZT2RUSC1-AS1 TMEM100PIEZO1 LINC01370UGT1A1 /// UGT1A10 /// UGT1A3 /// UGT1A4 /// UGT1A5 /// UGT1A6 /// UGT1A7 /// UGT1A8 /// UGT1A9ZNF702PPABPC1L2A /// PABPC1L2BUNC5ALOC100506504 BEX3TP53I3 LANCL1PSPC1 SLC11A1SETBP1 GGT7MIR6878 /// TARS2 HDAC5CA14 SIRT1HEMK1 COQ6LOC285181 SCGB2A1LOC283745 INO80CLIN52 TSC22D4PSAPL1 GFRA1

Page 152 of 781Diabetes

DNM1P35 LOC730101CLN6 BYSLSRCIN1 MMGT1CACNA1C DANCRFBXL14 PDS5BBTNL8 RNF139IGFBP6 COMMD1LOC729732 POLBTSC22D1 SLTMKDM2A MCTP1WDR5 JOSD1MS4A8 COMMD7CYP4F62P APOOLRP6-149D17.1 MRPL40THRB-IT1 /// THRB-IT1INPP1RDX IDH2ABCB9 ABOSLC9A1 TEAD2NR2C2AP PALD1CD3G CMC1USP19 PLAC8GPR160 VAMP5SULT1A1 ZNF799ACSL4 BAK1ZNF789 U2AF2RFX1 TMCC2ATP11C NEDD8-MDP1GNL3L TRIM37CCL14 /// CCL15-CCL14SCTRMYO1C ARPC3CPD MFSD4AAAGAB ERMARDGAL3ST2 ADH1CCPSF2 NAP1L3DAZAP2 /// LOC102723983KIAA1328SDK1 MAP2K1PRSS8 LOC653160HLA-DPB1 NIPAL1LAMTOR1 CLEC14ABC031864 /// LOC100507330 /// RP11-588H23.3RMND5BSSTR4 WNT5AENC1 APOBEC3CANXA5 GNAO1METTL15 SRSF9STAM2 STARD7-AS1PRO2949 KAT2BFAM213A SLCO4C1KLHL24 VWA7PTGDS ANKRD36CRASL11A BLOC1S2

Page 153 of 781 Diabetes

DCTN1 /// SLC4A5 VPS37DPDLIM2 P2RY2HOXC12 PRR22SERHL /// SERHL2 RSKRRHEBL1 MRPL45DNAJB6 /// TMEM135CAMK1FAF2 LOC150776RBL1 PLK4JAG1 DGKGC17orf49 /// RNASEK-C17orf49SORBS1MRPL16 UHRF1PLEKHG4B OTUD1LINC00884 LOC105373553GAPVD1 LRRC58SPATA1 ALKBH3EXOSC1 ZNF655ALDH1A3 PA2G4DNPEP POC1ABIRC5 /// EPR-1 PTAR1AP1B1 MKLN1-ASC14orf2 SLC4A3HS1BP3 SFR1EP300-AS1 USP5S100A13 ILDR2C3orf35 RASAL2-AS1SH3BP4 TENM2RPS6KA4 KCNB2SPINT1 IL1RAPRP11-69I8.2 RP9PRPL27A USP53SENP3 TIMM8AUTP15 PROCRXRCC2 LINC02246DLEU2L NLRX1SLC7A4 SPHK1RPS8 PODXL2AGTRAP TMEM98TRAP1 YWHAEEPB41L3 CPLANE1KATNAL2 NEDD4STK24-AS1 TOR1BMIR29A /// MIR29B1 NSMCE3RPUSD4 IFT122RAMP2 LINC00900TREML3P CEPT1BRICD5 AKAP3AVP LINC00242ARX ARL8BKLHDC10 TMEM8BPF4V1 FOXS1

Page 154 of 781Diabetes

SIK3 TTLL12DIS3L SEC24BMAP7D2 PABPC5PDE1C ATG2BSHROOM1 WNT10AKIAA1958 ARCPTPLAD2 SLC39A4BEGAIN TRAPPC2KCNJ8 DMAC1CIC HAP1SVEP1 MFN1XIRP2 CSKCLEC10A TUT1CDCP1 WDR73GOSR2 FAM151BCOQ7 TRPC4FAM127B SESN3C17orf77 LOC101928100POLE2 CSNK1G1CTPS1 ADCY7LOC286083 RFX2STAG3L2 /// STAG3L3 /// TRIM73LOC101928504FSD1L DUSP3LEPR SMIM22COG4 RNF138TNFRSF10A LINC01574CCDC30 HRASHNRNPA1P31 /// HNRNPA1P31OLFM1APOH KCNH1BBS4 RNF144A-AS1FLJ23867 /// QSOX1 PHYHIPVWA8 LINC00921SLC39A13 LCORVASP IFI35SDR39U1 GMFBS1PR5 WDR12PPIAP21 /// PPIAP21 CPXM2CCT3 /// LOC101927137HSD11B2COL7A1 ANKRD13CLOC389834 /// MAFIP /// TEKT4P2DAB2IPC6orf163 CD22NHEJ1 /// SLC23A3 RBM20ARPC4 /// ARPC4-TTLL3COL8A1SCO2 PIGWPEX11A LOC100130331NCAM1 PRKG1LDLR SEPTIN2PATL1 RPL23AP87EGR4 MAPK4AREG NT5C

Page 155 of 781 Diabetes

C20orf194 POP1SCN4B NDUFAF4RP3-486D24.1 ZNF644C1orf87 SLC26A6TDRD12 BHLHE41ZSWIM5 PYGO2LOC101928682 PHF14C12orf61 TMEM74BUQCRQ TAF3BBS1 MTX3ND4 IDH1LOC100507311 ENTPD2STAB2 U2SURPADAM17 PIK3AP1CHGB ZSCAN20DNAH14 POU3F1PAXBP1-AS1 BMS1P1DENND1C LINC00839PML NCLLOC101928388 LRRC37A4PPPP3CC CXCL6IK TNNI1OGDHL REPS1PCID2 KBTBD11CAMKMT SLC15A3CFH /// CFHR1 CARS2LOC100130700 SPOCD1RPS19 CRKABAT CRTC1GLMN UFSP2KAAG1 ZNF121CBFA2T3 MLF1HSPB3 PRAG1KCNJ3 CYBBLOC101927673 /// OTUB1MAP2K6LGALS9 DUSP22FAM222A-AS1 LOC100129046FUT6 SNAPC2ZNF121 LEF1GPRC5B ANKS1ASLC26A11 CAPRIN2PCNP BCL7CKIAA1324 LINC01560TPX2 PSMG1USP38 NDUFA4L2ZNF286A SLC20A2LOC102725382 CBWD6WFIKKN2 NFAT5LOC101928068 KALRNFAM46C LOC105373159

Page 156 of 781Diabetes

HOXB6 SQORPCA3 NADKEMP2 TRIT1MBD5 CHKAAK7 TNFRSF11ANUS1 /// NUS1P3 STXBP1UBR4 MFSD10CAMK2A CSRNP2TMEM158 CLTCL1LIMA1 LOC105372480ZBTB24 TTLL7ERVH-4 ZFPM1KPNA6 TCAF2TAP2 ZEB2LOC101928625 /// MED21HTR1FSTK33 PLSCR1IDO1 GYG1TRIB2 ZNF865LOC286071 NOP16ZNRF2 MRM2DDAH1 TESGATA3 LRRK2LOC100507577 /// LONP2LGALS3BPCPNE9 KCNQ3TSPO LOC100130744C12orf5 UBAC2TARDBP FEM1BZSCAN12P1 ASRGL1RAB8A WDR25UBXN7 LINS1RAB3GAP2 SPRYD7VEGFC BCHEFCN3 ZNF284JOSD2 ZDHHC1RBM18 MTERF3WWC2 WLSRSPO3 ZNF66CELF3 TMED7-TICAM2SOD3 CIARTCTD-3080P12.3 STAG3L3TOMM5 COPECCDC152 MYO1CAGRN RIIAD1MGP FNIP1LOC100996542 ZNF319PRMT3 LRP10CCDC14 ZNF429TXLNGY ADH5TAS2R10 GALTSLC2A10 KIF19

Page 157 of 781 Diabetes

TOB1-AS1 NTRK2EFCAB4B SNED1MEX3A ISY1LCN2 AGMATNMRK2 ZNF586LINC00086 MERTKPICALM RDXULK4 GIPRCHAT SCN3ADDHD1 APPL1EVI2A BIRC5FSTL3 PHTF1POLD4 SRRM5CSRP3 SPINDOCMOB3A FAM111A-DTPRRX1 ARHGEF17ZNF252P-AS1 OPRM1BRAP TMEM81RP11-263K4.3 LINC01011FAM50B LOC100506885LOC101928729 SLC4A4PIGQ PLPBPCSNK2B /// LY6G5B FCMRCDC42BPB AKAP11EDN3 LOC100128288LOC284648 CTNSHAP1 JAKMIP1PTCH1 DUSP7ZP1 CFAP46BRI3 /// FLJ30064 METTL8LOC101927157 /// NIPAL1MID2GGA3 NEDD9RP11-473I1.9 CTBSLKAAEAR1 PLEKHO1LOC100996385 DMDTRIP12 ELK3NDRG3 SLC2A10GLYCTK PPA1NDNF PEA15BC042366 RP9FUT10 GIMAP6LOC100507600 ZNF252PLINC01125 KDELR1CYP2D6 /// CYP2D7P /// LOC101929829ACSS2CLMP CYSLTR2AC114752.3 ALBKLF3 FOXK1ARHGAP8 /// PRR5-ARHGAP8SULT1A3CLCA3P SULT1A4MED20 DPP6

Page 158 of 781Diabetes

CCSAP VTCN1EFTUD2 PHF24CRTAC1 WDR44PHF12 NIPAL3CCDC150 FAM78ALINC00883 DBPRBM14-RBM4 /// RBM4TSC2F2 BCO1ARHGAP22-IT1 SLAMF8S1PR3 BDH2CENPP /// LOC100128361SEH1LLOC100506639 /// ZNF131HSD17B14LOC101928495 C5orf49TBL2 ATE1DLX5 C6orf47NUBPL GPRASP1ZBED4 UBAP1LENOSF1 LOC440895LRCH1 USP47CEP63 NOTCH2NLBAMPD2 RALGPS1DDX3Y ZFC3H1ELAVL3 DBTLRRN2 HACD3LINC00282 CXorf56TMEM237 HECAPLCD4 SPDYE16LMNA SMPD3RIMKLB CBY1SIRT4 MTMR9IFNAR1 RARRES2SYT3 GCNT3GEMIN4 CENPFNAB1 PHGDHEPS8L2 LOH12CR2ACAA1 RAB25AF198444 PRKAG2KRT8P11 /// KRT8P11 FMO1STYX ZNF385ARPUSD3 KBTBD3FAM20A CES4ASTIP1 THOC7AP001462.6 XPO7TSEN2 DCLRE1BSH3D21 HIKESHIATPIF1 ARMH1AOC3 HCN4GRM2 C7orf25IRS1 HABP2HSPA14 LOC644634

Page 159 of 781 Diabetes

RP11-384L8.1 NMIRASD2 TRAF7ETAA1 SP1FLJ35934 MTREXSUV420H2 GPAA1ANKRD1 COQ9SCAND1 RBMS2UBA52 SHROOM4KLHDC7B SDSLSOX9 ARHGEF11GGN EEF1B2WAPAL LOC145783ZNF35 SPTSSAMCAT PIGVNARS2 HAGHRP13-122B23.8 CACNG5WDR37 EMC7C11orf30 FBXL19-AS1TRIM66 PLCD3CYCSP19 /// RP11-3L10.1EIF3IC16orf13 FAM241BPERM1 WFS1MED31 VSIG10ARHGAP25 C5orf63AP1S1 THSD4SPINK6 UBE2Q2MYO5A PSPNCHL1-AS2 /// CHL1-AS2GJA1ZBTB37 POTEIIGF1 FYTTD1EXO1 CCDC32OXGR1 NORADFKBP11 LARP1FAM71B TNFSF4UXS1 TOLLIP-AS1GLI1 CTSAECI2 SPI1ATXN2 SLC16A12CPT1A SMPD2MEIS1 MYO1ESOX21-AS1 C11orf52CD97 PWWP3BRNASE7 NASPCDC42SE2 GNPDA1ACE OLFML3FAM207A MRS2P2SLC20A2 ZNF79FBRSL1 ATP7BKIF15 ALDH1A3

TAF6

Page 160 of 781Diabetes

METTL7BANKRD53PSMB2C18orf32METTL17AMFRCCZ1EPHA4NSFL1CPDCD6PRR5LINKA1PRPF4BSOWAHBHTR2BSNRNP35CHD4BAG1SLC19A3RRP15CDC26TBRG4TNFAIP6STAG3L1LOC101927178VWA5B2WNT5BNIPSNAP3AMRPL21PRR34-AS1USP35ATF7IPPOLR2MCNOT3LMNTD1S1PR5ARL2SECTM1TNRC6CPEBP1GCASNPHDENND10P1LRRTM2ZNF490RHOGCIB1AP2A1LINC02495GIMAP7

Page 161 of 781 Diabetes

CHMMFAP1FRKNAT1PRH1-PRR4FRAT1TMEM150ANDUFB8ILKAPNUDCKCNQ2FOXP1GAS6THBS3TBXAS1IPCEF1ABCD4PAK2PIPOXMICAL2C1orf35DYRK1ARNF216P1CIB2SLC25A5PSMF1PLXNB2KLHDC7BST14COQ5GPR37SYNDIG1HHIPL2RASSF2SURF2RGS5TUSC3CCNQZNF530PGS1FOSL1RBFOX3RNF19AABHD17CPYCR3ADGRE5CLDN2COMMD3CCNJINS-IGF2

Page 162 of 781Diabetes

KLHL41ACOT1GMIPDGCR9TMEM161ADNMBPJUPCTSSPTPN2UBE2ATMC4SMARCA1FUZSOCS4FCHSD1ZRSR2PPP3CCZFP62C21orf62USP21RIPPLY3CPLX2DNM3C1orf21PLEKHG1RPL7L1SDHAP1FGD2SBK2CNDP2LAMP5SPTBN4PLRG1SONLINC01750TNIP2LINC-PINTCSTBMKLN1DAD1LIN7BZCCHC2SIRT2OVOL2FNBP1ZNF471KMT2CC8orf44-SGK3BCL3ZMIZ1

Page 163 of 781 Diabetes

FABP5TWSG1RGS19LOC101929243UGT2B15RPS16FAM49BBATF2PTGR2SSX2IPZNF441N4BP2L1FHL5ITPRIPRABGGTAFGF14-AS2FEZ1CYP20A1TPRNWDR91LOC101930071EXOC7SPACA9GLS2HSPA4PIGKLONRF3CDH18TRAF3IP1EFNB1BHLHE40-AS1MEMO1FMNL1SUN2ZNF273OSBPL1AMEG9SMIM32SRD5A3IAH1CLPTM1NESMLIPTMEM127MRPS30NR2C2APANP32CSPATA18MAP3K2LOC143666

Page 164 of 781Diabetes

ZBTB24ZNF20KIF5CDDX60DCXRSMAP2CDK1MCOLN3FCGRTPEF1LOC389765EMID1NT5DC2LGALS8EFHC2ZNF544C3orf35EIF2DSNORD140KCNJ11PLAGL2METTL23FSTGPR142MAP2K3LOC401261PIM2ATP6V1E1LOC101929767PEG13ORMDL2TOR1AIP1LOC100129540GPD2GEMIN6MROH7ANKEF1ZNF665SFTPA1GATBC19orf12MMP2MARCKSMED27DMTF1RNF144ADCP1BTINF2CATFAM207A

Page 165 of 781 Diabetes

GPR108TTLABHD14BGALNT18REG1BTNRC18ST8SIA5PMEPA1PKNOX1CD8ASHROOM3FCHSD2NOMO2POLDIP3GNG7LENG9RERGDLSTDNAL4ANKS4BDPYSL4BAATRILPRRN3P3AFF4TRPV4ESRRGCKS1BGPLD1COPS5CA12EMP1LATS1LINC00899LINC00951TRMULINC01554PPCSSYTL1NMD3HLA-FPCDHGA1ELMO2ZNF197NDUFA13PPIL3HIST2H2AA3HIST2H2AA4CHCHD6DKK3

Page 166 of 781Diabetes

SNAPC5KRT8PTGDR2ATRXAGFG1WDR83OSCES3CRTAPLOC102724814PDIK1LCCND3FSCN1NOVA2RRAGCTRAPPC2LCEP128DUOX2STRIP1CAMKK2TINAGL1LINC00662ZKSCAN3FAM193AZNF106FLRT1MICAL1STXBP5-AS1CHD2LGALS3RBBP7SOCS2LOC105375690TAF11ZNF681LOC388282HSPBAP1EMC2XRRA1PDZD2NYNRINHERC1ATG7SDHAP2SLC22A23MESTIT1WDR78CATSPER3MIR762HGGPATCH2YARS2

Page 167 of 781 Diabetes

NXPH3RUBCNST3GAL3IFNGR2ZNF628TFPIITGA3INAADOGDF6PLSCR3WDYHV1TRAPPC13ZNF461MOAP1TCHPOS9MIPOL1GINS1CEP44NSUN5VTI1BPCGF2SHISAL2BWDR97MAST3EXD3CCDC43DEKGALNT1RPS13FIGNL1PIWIL2LOC101927377EBPEP300-AS1FAAP100LOC100507053HENMT1LOC101929599SGCAMARS2LRRTM1EGFEM1PFAM171A1BTDHNF1A-AS1BCL2L13ABCC5SIVA1

Page 168 of 781Diabetes

METTL9HDGFL2NCMAP-DTEID1ADAMTSL2ACCSARHGAP33LMTK3HLA-DRB5E2F1AFDN-DTTONSLSPDL1KCNE4ERBB3SLC16A5HIGD1AZBTB6FLI1ADPGKANXA11FAM120AANKLE1ATP10BADAMTS10SLC35A5RLFRAMP2P2RX4PEAK1ADAM23MAFKPDE5ANKD1FAHD1THY1CPS1CELF4MRFAP1L1SEC14L5CNPY2FAM32ABLMHWDR26RAP1ANPIPA2STK16TJP3AGBL2STARD7

Page 169 of 781 Diabetes

TNFSF15RAB3IL1CAPZA1VPS4ACNPY4MACC1CRATZNF282CSF2RBRREB1HIP1LRMDARWDD2BHOMER2HMG20BCCDC120RPS5NDST2C14orf119HCKST7LPRKACALIMD1-AS1UNC5BHAUS7WIPF2LUC7L2ASPDHZNF326BCAS4SNX7CBLN4KIF12LTB4RAARDERCC6L2PPCDCHGH1FUCA1ZNF703PLIN5KLF2FZD10UFL1BEND3P3DMPKCFAP99ZFHX4PLCE1DCAF4

Page 170 of 781Diabetes

TCTACSGALNACT2EPN3AGAP11GLCEKIAA0100RHBDL2NEK6ALOX5ATP6V1HLRRC8ANUP133PEX5USP34CACNA1CTRIP10ZFP36L1SCYL3RBM45UVSSAARRDC4DYRK1BCHMP1BUNKMAST4-AS1ETV4TESMINMSL2SRRM1KLHDC7ALOC653080AOC3CYP4F3LUZP6MTPNRTL8ARPL22ZNF286BSMARCD2IMPDH2LOXL2PKD1P4-NPIPA8PDZD4RNFT1-DTMYCBPEPHX2DNAJC8PLATPOLR3KMASP2

Page 171 of 781 Diabetes

SOX9ACAD10MORC3CDH22PIGBSLC17A4JPT1PP2D1NRG3TLE4DPP4ZNF778LRP4C6C1SKIAA0895LMOSPD3HSPA2LACC1N4BP1CTPS1FLAD1PPFIA3IFIT2PLPPR5ALADPRKXP1AMMECR1HABP4ATMINLINC01144HYIRAB39AMRPL11CCND1ACTR6S1PR2SMIM12MDM2GPRIN3ZNF433LOC101927157MLPHCEP78P2RX6GTF3C3SETD2LINC01569PARD3BSLC4A7

Page 172 of 781Diabetes

ACVR2ANFASCSDF2ADAM15LOC100294145NOXA1DOP1BPTTG1CYP4F12ADNPPRMT7LOC100996419LOC100506098SBK1FHITLSM1PCNTLOC100505501RAB42HAS3LINC00847LOC100132249PROX1RRNAD1ANKRD52PID1C7orf50ZNF513SCYL2CLCN7RNF39FBXO17CAVIN3KMT2BWRNIP1HHIPL1CBWD3MTUS2AP4B1-AS1ADAM8LOC202181ITGA11BASP1RBM34PHLDA2MOB4USP18TENT2MAGOH2PPPP2R2C

Page 173 of 781 Diabetes

ARRDC3PPT2KATNAL2FBXL8NENFZNF101IFNAR2LARP4SLC46A1PGM5SLC2A1ZNF217MRPL20KLC3GBP1FNDC5EDEM2ABHD14AKCTD15FAM66BUNC93B1IDI1SRP9UQCRC2CCDC7PPWD1HUNKCD6HIF1ANSLC10A5DERPCPIAS2PHLDA1SGPP1HNMTCCDC57BARX1USP19PYCARDCDC42BPASERPINI1ACTG1P4SHFIL1BMPV17L2GNAI1ADH6CLEC11AKCNA5ATXN7

Page 174 of 781Diabetes

MRPS12PINK1-ASSTOX2BMS1P2-AGAP9ARL13BEIF3LTTBK1NCK1-DTPLCL2UROSZNF609GLIS3HECTD2STAMBPRFPL3SCPT1BKANSL3ACTR8CEMIP2REEP3SLC46A3C9orf78NIT2IFT27ENPEPAJAP1SGMS1-AS1TATDN1DUSP1EXOSC6VTA1SIRPAMAT1ALOC101927751LINC00511RIF1TMEM222GSDMDHAS2SOGA1B3GNT3ACOT8SPAG5IGSF21EXOC3ARHGEF38RTP4ETV7EPOPREEP2

Page 175 of 781 Diabetes

GGT6KIF9LOC100132813KIF3CLMNB1ARHGEF25FHOD1CAND1CTAGE6TRIM65STMN3LMBR1HSD17B11LOC112267983BRD3TSPAN15GLB1L2MGACDK5R1ALKBH4ZNF808TMEM107NEIL1ZNF512BSSH2PLPP7NSG1GAP43RAPGEF4TCF25BLMHERC5VCANPLEKHG6ETFBZNF107CYC1MAP3K12SERINC1CYTORPIK3CABIVMPTPRZ1AZIN1SWT1TBC1D9BARID1AARL4DEVI5LFBXO28

Page 176 of 781Diabetes

XRN2GGT5LINC00537HTRA2RCL1LHFPL4GOLGA8JGCNT1PAUPARZFAND5TMEM230CASP9SYTL2ZNF890PLTA4HNCBP2AS2TMEM246COPS8IFI6GDF15BNC2ALKBH6GK3PGRSF1TPI1P2NEAT1CYP2U1ADAM1ASTK32BCHAMP1COX14FABP4SEMA4DGLIDRINO80EGPR161N4BP2L2NDUFA6ZNF160PPIFAURKAP1MTMR7H1FXDEPTOREPN1TMED8SUMF1ENOSF1PGGHGNUDT16L1

Page 177 of 781 Diabetes

VWA3BFAM90A1EPHA1TMEM38BCHD6DNM1TECTACYP3A5SYT12UBTD2FXYD2ZNF318TMEM147CDK2SLC35E4CCDC173L2HGDHARHGEF9EXOGCPNE3GREM2PHC3TRIM44TIGD3KLF8SLF2HSD17B2MED18FAM81AFBXO44DUSP15AQP1RBM15BKIFAP3LIN9DEF8LGALS2PCDHGA7SLC7A5FUBP1MYH3PRSS53PCYT1BSMARCAD1PCBP2-OT1CLPTM1LPACSIN1IFI44AMIGO3RIC8B

Page 178 of 781Diabetes

NTAN1OGDHLZNF768MYH9PUDPPCYT2NPSR1-AS1ADSS2ATPSCKMTFRYLPTP4A1CD24PCED1AMSL1DUS1LZNHIT1CLDN3SERPINA3CDH6TNFRSF1BS100A11MCM3AP-AS1ZNF423TTC39CTTC21BPCDHGA4PSG4MYBPHLRRBP1TMA16NFATC2IPFOXM1ACTR10FAM122BCOA3ZNF436HNRNPA2B1CEP63PPP2CBEXOSC8ELOF1WFIKKN1CCDC18-AS1TUT7NBPF9CPED1PPP1R9AHOXB6UIMC1ENPP2

Page 179 of 781 Diabetes

LINC02532ARHGEF2GATA2-AS1CHD1LFPGTHLA-DMALINC00997LOC100268168LDLRAD1EAF1EN2ERC1KCTD7KRT23CFAP57UNC80ICAM3ASPSCR1UBE2SZC3H18-AS1ZNF467C17orf53MIR99AHGARMCX2SLC25A6BOLA1POTEMELOVL2PGBD1TRPM7PRDX5TMEM176BOPA1IPWCHN1FLJ46875CFAP70PCM1SPOCK1TP53RKKCNF1DENND1CSNCAMID1IP1TMEM256MRPL32CNNM4TANKLMNAPCDHGA10

Page 180 of 781Diabetes

CCT4ZNF502NOA1BEX4RBBP4CA5BP1-CA5BHOXB9PMS2P1MAPKBP1ZFP30MRPL4KLHL26CTDSPL2TECRZNF785LINC01431LRRC57ZNF624MALT1MVB12AAPLP2SPATA5L1FBXL2KLHL17ATP5MDASAH2BNSA2D2HGDHGALNSAPBB2SRSF6CDK19EYA2SYNE1SLC14A1ITGA9SNRNP27EXOC6CCL2CYBRD1ENHOZNF511LOC152048SMA4ZC3H12CWDR7MCATLIMD2PPIHHEATR6

Page 181 of 781 Diabetes

HRAT92COLEC12ACTA2MAP3K15FAM234ALINC00909POTEECTSLRNF181LIMS3-LOC440895PTPN6TNFRSF10CDOT1LSCN4BFUNDC1BCAP31GABREPLAUUGT2A3TMEM50AMRPS34CTSHNCKAP5LUBR3DKK4SYNCRIPTTC39A-AS1SLC29A2UBA3NDFIP2RALYLCTSKUSP7CLCA4-AS1SFRP2SLC27A1FAM210BSESN1CDC42EP2LOC102724562PRTGIWS1NPHP1ATRAIDCBR3-AS1NFIBSUPT20HNBPF26MCM2SLC25A1

Page 182 of 781Diabetes

CHST5FRRS1RGMBLOC440570ABLIM2NDRG2C4orf33SIAEC17orf58BCL2L10KHDRBS3LINC02731ZBED9FOXO6CCDC189ADGRV1TRMT12KAT14GTDC1HEPACAM2ELOVL7AGLSLC45A1TMLHEPOLDIP2PPP2R2DNDUFB2MAL2FBN1RORCUBXN2BGNL3LCOL16A1PLTPRTEL1HELLSLOC101928907SLC7A14UBE2L6RAD51-AS1TMEM236PLEKHA2CRYZL2PPDCD1LINC01273DNAJB6DCLK3ZNF18DBNDD2GPRIN2

Page 183 of 781 Diabetes

H2BFXPLOC100101478LDHDCENPLDNAJA4MSCSALL2UBASH3BFAM85AFAM214AWNK4SLC16A11IL6RDLEU1DCXHIPK2STAG3L2ZNF439CERT1FBXL18RPS2P32MEX3AFAM21EPHEY2BAIAP2HDAC8PI4KAZNF788PPAPPA2EFNA1TENM3LOC114483834SLC30A2ZBTB1ARSIMEAF6HIST1H1CRHOVRUNX2CCDC198PLEKHG4RNF139-AS1MOSPD1SMG1OPA3TOLLIPCDHR3LCATDENND2DGDE1

Page 184 of 781Diabetes

EEF2KPSG9SNRPD1ERFLAGO2SP100LINC01816ZNF440EVPLSPC25FAM200AC2ACVR2BPGAP1ZNF767PPITRM1TRNT1SAFBCLDN6FAM160B1CA9NDUFAF3C1orf131RNPC3MFSD3IRX3M6PRGSTZ1GJA3TTC39BAHCYL2CCDC87IRAK3KLHL31EIF5BHSPG2TMEM18SAP30L-AS1TGOLN2VCLPCDH12LATARHGAP32UQCRHUHRF1BP1DPYDPAXIP1-AS1TSPAN18TFRCTHUMPD3

Page 185 of 781 Diabetes

MED24ARSJTMEM238KCNB1MRPS16CD74MIER1DAGLASPINK1MIOSSORD2PZNF727SLC24A1TCEANC2MINDY3KDM5ADEGS2CUL7AAGABPHF10ABCA1IL3RABUB1B-PAK6ZNF185TGFB3GBA2MRPS17VWA8ZNF330TOGARAM2SH3YL1COA4DNASE1L1EEF1AKMT1GRAMD2ANECAB2SERTM1CYB5R4ZNF37BPMAFG-DTEIF4EBP2A2M-AS1ANKRD16NRG1DCLK1DHX29SLC5A1FDPSP2DIP2BSEPTIN9

Page 186 of 781Diabetes

PSMD11CEP126FAM20BPREX1ZSCAN16ZDHHC8P1COL14A1DGAT2MYEF2FHAD1B3GNT7ONECUT1PIGUPLXNC1RAB11FIP3SNHG21METTL21ABRD7CAMK2GCCDC103PCCAPDE8ASSPOFAM83GSYNGR2VILLTRPM2CLVS2DLG3RAB40AC3orf38LOC105376114DAXXZNF276PSMG3-AS1ZNF200IPO5BRD2ATP2B1-AS1PKN3ANGPTL1DOCK7DISC1ECHS1TCIRG1HUWE1MED15CDKL3SURF1HILPDA

Page 187 of 781 Diabetes

TSEN15DPY19L2TEAD1METTL6TSPAN8SYT13CCNJLCOX15DIXDC1KCND1LRRC36CPQA4GALTPDLIM3FUT2IFFO2ZNF700COA1NUP50WFDC2LINC01139SNRPD3ALX3TCAIMAK6PSMB1ITGAXLDLRAP1ZNF883TAPBPLPPP6R3LYNLOC100130691AKR1C1RASSF10APOL1SLC38A5HYAL1BMS1P4BTBD3LRRC24FAM133ASKILCDC42BPGZNF625AKR1C3EEF1DSUGP1ZNF419PPP4R2

Page 188 of 781Diabetes

NLKCCDC78RALBGAREM1ZNF239PDE4DIPHDDC3NUP42TCEAL8DYNC1H1FBXO22GMPSLOC100130950KMT2E-AS1FAM155APLEKHB1ZBTB8OSVPS9D1-AS1SMG1P6STK35TMEM144SERPINA5SPATA6IDI2-AS1IL10RACD83MPHOSPH8RTCA-AS1MPDU1GPN3RAPGEF6WDR63ATOX1MICALCLCHAF1BPPARGADAP2ITM2BBACE1CENPORNF6UBXN2AFENDRRDHODHZNF385DMAP1BTWNKMED30TULP4FAM135B

Page 189 of 781 Diabetes

RFXAPLINC01003LINC02106PROSER3KITLGDNAJA1TLDC2OBSCN-AS1LTBP1PIP4K2AC3orf33ESYT1CDR1NIPBLYBX1NHSL1DNA2HOXB4FAM13ATMEM60CATSPERBCUL1EFNA3PCDH20GRHL1CALM1MAGEF1GAS5CSTF3TUBWNT3CTSFCPAMD8ERICH3CTDSP1ZNF320FAM83BGPR39CTSDARHGEF37AK9IRF2PRICKLE4C4BPADUSP19BAZ1ASLC19A2LRP11NAPGZFAT

Page 190 of 781Diabetes

RTEL1-TNFRSF6BPTGS1DUOX1FAM47EIGSF9CCZ1P-OR7E38PAFAP1ANTXR2FBLN7SLC24A3OXCT2BUD23HMBOX1LITAFHLA-VNECTIN2PSMB6SIDT2TMEM176AMYO1FNDUFA4PYCR2LAD1C3orf80ADA2NME1GPR143TBCASLC37A2SERPINB2SH3D21CALCRLLIG4HHATZBTB7AMAPRE2UCNSRGNCFBBABAM2COL1A2EPHB6CASP3LINC02389ABCB1COL4A5PDXDC2P-NPIPB14PPSDZSCAN1ELAC1

Page 191 of 781 Diabetes

FEVDHRS4-AS1DENRMBIPERFZNF573EGR1DDX28PKHD1NDUFA9CACNB2PSMD14GOLGA6L4KDM3BTLR1SELENOMCYFIP1DR1NMT2COMPPIGZZNF638NRSN2-AS1YTHDF3-AS1RUNX1NICN1EFNB2NFIXSSTR1ZNF891TMC6METTL27CAAP1PLBD2WAKMAR2ZNF615ADGRE2ACAP2CHI3L1ANLNWRB-SH3BGRWDR5SCAIPAQR4CDK8CEBPDZHX2GJC1FN1EYA3

Page 192 of 781Diabetes

AP5S1TMCO6ANKRD13DMPP7PANO1ZNF251FAM156ATSPAN7DBH-AS1RTF1NFIABMP8BPRKACBSPCS1CHODLSLC39A14AKAP6ARHGEF16SLC27A2TAS2R5GAS8BDP1TMEM163PODNTENM4TMEM132BAKAP5STAU1APPBP2TBC1D17GIGYF2ZNF765SIL1SAXO2EEFSECFBXO15AMHZFPM2FAXCSLC49A3JAG1SLX1APOLR2J3TDRD7MSL3P1NMNAT3PHYHD1GRHPRLINC01586FAM149B1

Page 193 of 781 Diabetes

LRRC75AFOXN3-AS1ANKFY1AP2B1PTPRMSPON1GTF2H3VWA5B1LRRC23UXS1TAF2PSMA6MRPL15AQP3MED23PKP2ENGASEADCK5TMEM63BLEAP2KCTD8SEPT5-GP1BBC1orf116UGT2B17DGKENEK4PTPRAJPH3ZNF623LINC01530TRIM8MRGBPXPO1ELK4CNNM2CPT1AOLAHZNF559EPHA8LRFN1AKR1B10TCF7KIAA1107LINC01089LRIT3GRINAPIAS4TSPEARSIRT7ALPK2

Page 194 of 781Diabetes

SMSFLVCR2RGS16CCDC168FZD2KCNJ15FOXRED2TMEM132EMX2HIVEP2WDR70MPP5CHRDTSPAN31LOC100129034PARD3CITED2MRI1NTMT1TRABD2BRNF10FANCILLPHABCC3CENPURGL3AHCYL1LNPEPVAMP2ARHGAP27NUDT8ADORA1SMC4ADPRHL2PABPN1TNFAIP8L3ZFRC18orf54P4HA1GPC4PRR7ZNF879ZNF271PHEBP1ARHGAP6GRB7FADS2ZNF71FILIP1LSTS

Page 195 of 781 Diabetes

EIF4EMEGF8UBE2E4PKDSRAP3M1IRF5COLEC11PSMB8-AS1SHPRHLRRK1WDR47TPK1HLA-DMBLINC01754FBLN2ERLIN1TPM3P9EIF1B-AS1CC2D1ALOC101929188PEX16PRPF39FLRT2INSYN2AUBE2R2BCAP29RARRES1GXYLT2B3GAT1RGS1MTSS2SPRR2AKCNH3ADSS1CROCCP2CBFA2T3IGFBP3MED25PPARGC1BMSH5IER3MGAT4CBCL7BZNF358MCM5ZSWIM1ZNF676RPS25EPB41L4BPTGER3

Page 196 of 781Diabetes

JAM3FIS1NEK5FOXL1NCKAP1LMANSC1PCDHB9GJB2CETN3HMMRSMARCAL1HINT3SCRIBNPIPA3FBLN5DCNKLHL36ZNF250LOC100310756ENTPD3-AS1ZNF227SLC8A3AIFM1AIMP1F13A1CLEC2DPPFIA4SCRN1ARHGAP11AUPB1FRMD6ENO2GUSBCOQ3ALDH7A1LYSMD1MAP7D3HBEGFKCNC3EIF4A1SLC25A29SHMT1RHBDF2EPC2ANO7PHTF2UTP23SDC3RPH3AGOLGA7B

Page 197 of 781 Diabetes

BCAR1OSGIN1IER3-AS1ILF3-DTDCAF6TMEM59ANAPC4LOC102723665PROM2C17orf75FSD2PRLRCD34TPST2PCDHGA8ZNF835ATP5F1BLTB4R2ADAM20P1SLC12A4INHBATMTC2CYP2C8POLE2SEPTIN3PIM1ZC3H7AFLG-AS1APCSPDLIM7GRM6EXOC5HNRNPUL2-BSCL2HLFPPIL2GFM1CPXM1FNBP1LTCF21SCAMP1-AS1NKX6-3EIF6SLC22A4ZNF836GAS1EMC4SFMBT1MAPK12ASB16LOC100996724

Page 198 of 781Diabetes

LRRIQ1RAMP1HSD11B1LSSH1TCF12EP400P1GIN1MED14CELF3PHACTR1RYR2PEX2ZMPSTE24CD58IFNLR1NIP7RASGEF1ATACC3SCN8ADPCDSEMA6CS100A10RAD51CMAP2K5LOC100289561ARSGLYPD1DEFB1JCADZNF793-AS1NRSN2PTGES2-AS1SOWAHAANKRD28CCBE1MT1LADAM28RAP2CDNAJC4RRS1ATP10ANADSYN1MDFINPM2CLDN9TRIM16LDACH1CTXN2NPDC1PNN

Page 199 of 781 Diabetes

GPN1NOD2PAPLNUSP11CRPPTRHD1LY6ETLR4FAM13BNPIPA5RASAL3ERCC6GUSBP1ZNF579BRD3OSGPTPARGUFSP1TRIM25LOC100132356KXD1INO80DRBMXL1PHF3ZNRD1SH3GL1P1KIAA1217OSTM1ZNF592CGREF1CCDC159LYPD5GLE1KIAA1841FOXO1TSHZ1NUDT1WDR35PVRIGNPTXRZNF146PSMB5ZNF616MGPDRAP1DISP2WASH5PHMCN1CRNKL1CCDC39

Page 200 of 781Diabetes

PPA2ZNF557SRCAPJPH1HIST1H2BDPRKD3MESP1GOLT1ACDK5R2LIME1CCNFCOPZ2MTHFD1GABBR1EMILIN1KIAA0586RBBP6SLC1A5MEI4NMNAT2RRAGANAPEPLDZNF876PTBC1D3LNAXDAUP1STK11IPPALM3C9orf163GDPD5EPDR1DTD2ITGA7C9orf64GBAP1VPS37AIL16ZNF714FMN1SIM1SLCO1A2ATP2B2CERCAMLINC01465AP2M1HHLA2GPR119HOMER3ZNF699CLIP1

Page 201 of 781 Diabetes

SRSF4LOC101928595RALYHS3ST3A1HAAOCLN8GGCTKHDRBS1EPB41L2CARS-AS1DCP2TGFBIFAT2FSTL4CASTOR1LOC101927811CLN3PLOD1IQSEC1ZNF385BCOL10A1ST13CRY2PDCL3P4KCMF1ZNF512HIST1H2ACZNF175DMXL1ZCWPW2ZBTB48MARCHF1PRICKLE1MAT2ATRIM9NUAK2CXCL5MARCHF9ZC4H2GAD1SUN1TMEM258RAP2ATHAP10TBC1D2HMGCLLOC644936RPUSD3C2CD4D-AS1RAP1B

Page 202 of 781Diabetes

RAI2SLC41A1TBC1D7-LOC100130357SRD5A1TMEM80DPH5GCNAPOC1B-AS1HECTD1SLC9A3-AS1LINC01315FGD5-AS1GRAMD2BTHAP12KIAA1522KLC2UBXN10PIK3CDTMCO1-AS1ZNF493VPS33BNDNFBTG1APRTLRRC8CASAH1SFSWAPCERNA1LOC100287015SFTPA2COL12A1UQCC2DSCAML1DAP3DIS3L2ZC3H12BTEX10SNHG9RENBPSTEAP4SERINC5TOXSAPCD1VCPWWTR1KRBA1NR1H4HERC4CSE1LTMC5

Page 203 of 781 Diabetes

CA11TRAPPC3TBC1D5CCDC151MRPS15DNAJC6ZKSCAN4FHL2KCNQ1TSLPCLTCRHOULOC101927021ATP6V0BFAM27E3GHET1MRPS30-DTDEUP1CMTM8EP300PDZK1IP1BMP4NFE2L1CACNA1IPOLA1ZNF503-AS1RASSF3GPBP1SMURF2P1-LRRC37BP1POF1BFBXW7ZBTB3GUSBP9SERGEFLOC100506476GPALPP1NR2F1RARBFAAHCRB3H2AFVZSCAN21FSIP1UTP14CCBR4GDF1MARCHF10ITPRIPL2LOC102606465CLSTN2

Page 204 of 781Diabetes

TPRRPL10LPAR2IRAK4PGM2L1PTBP3FKBP1BEFCAB10SLCO4A1DENND1AASIC2ABLIM3ADGRL2CSF1RSLC22A18ASZNF614TTC14NFKBIZIFI27L2DCAF15LOC284454SH3BGRL3LOC105373383CYBACSDC2GRIK5GPRC5BPSTKKRT19SERPINA1FAM229BERI3-IT1KIFC2CACFD1HINT1TRAM2BNIP5SMIM8ABHD12LINC00471CCT8SPG7SERPINA10ACYP1RRP7BPSLC25A14ATP5MF-PTCD1PPP2R5EPNLIPRP2GPR37L1

Page 205 of 781 Diabetes

TMEM123LINC00115ZNF721CMTM4TCIMANP32AP1OAZ2RGS22MTERF4C9orf16TMEM260RPL34-AS1LYPD3FYB1NUP160FAM234BBACH2PANK2LBX2-AS1CAMSAP2LAMP2DGCR6LOC102724770MARK3EDN2TRPT1PPFIBP1FNDC3BPOLR2J4PTGIRRUSC2SPAG16TMEM158OBSL1LINC01806WTIPLOC105371763EML1PCDHGA9TXNDC17TMEM255BIARS2LINC01637TMEM47BSCL2MMP1DCTN3SPATC1LZNF669SLAIN1

Page 206 of 781Diabetes

INPP4ASAT2TTC8TMEM139NUP107NEK3KIAA1257LOC283177SERP2TMSB10MTCL1DENND2CPSEN1CDC42BPBALAS1LIG3PRPF31LIASALDH9A1PYGLBRMS1SOD3TMEM41AETNK1OLA1BAIAP2L2CRYABPRPS2CDK9DNAJC17NKTRINSRFGL2ZDHHC2LYPLAL1FAM216APIGRADAMTS15C4orf48TRAF3IP2CASP8AP2CBX2SSC5DFUNDC2RRHCEP85LOC100132057BMP2KMRPL28AOC1

Page 207 of 781 Diabetes

POLR1ACMASPSG5LINC01481TNPO1MIPEPP3CAPN2PCSK5GRK6GNPNAT1DICER1-AS1ATP5PDS100BRYBPARXKDM3ACASP10SETDB1LOC100996720GAS7MRPL37APPFAM83HDACT1TRAM2-AS1GMNNMIF-AS1HSD11B1GAALY6HTTC31TAOK3CTXND1SPG11PAXBP1-AS1LIPAKLF11KCTD2NRARPCEACAM7FRG1-DTPELI3ERVK13-1MRTFBSMARCD3EPHB2SLX1BGPATCH11TXKC2orf73

Page 208 of 781Diabetes

ZMAT1ACSF2C6orf226OPHN1ASH1L-AS1CCHCR1GABRR2DHX34ANKRD13BRBM5-AS1GPR183DACT3C11orf54DDNTIAF1MYO7ARNASEH2BLOC105447645DIPK1ABCKDKZBTB7BSPRED1SENP6TMBIM4FTCDFAM201APAX8TDRKHCUL9IGSF3ANTKMTBANPCLN5AATKFAM189BEFEMP2WDR76EMP2ZUP1NATD1SLIT3BSGPHOSPHO2-KLHL23CAMTA1LOC101928371GABPARGS10COX20NME3CITED4

Page 209 of 781 Diabetes

ZNF546HOXA5SVILITPARHOCFER1L5HEATR1CPMRAB3GAP1ZFP37LGALS1GLB1LLRRC14MCF2L2AKT3ZNF781CAPN3BIKANO9

Page 210 of 781Diabetes

T1D T2D BFAA4GALT SYBU ARF4A4GNT MFN1 CYB5D1AADAT FUT6 ZNF598ABCB1 HAX1 MFSD2AABCG4 TCEA1 RRP12ABHD14B ERO1LB HYOU1ABI3BP AASDHPPT HSPA5ABRACL PRDX4 HERPUD1ACE SRP72 CYCSACKR3 APEX1 SLC30A8ACP2 SERBP1 JMJD6ACP6 IAPP SYVN1ACSBG2 SPCS1 KIAA0513ACSL4 IARS LZTFL1ACSL5 PSMG1 MYBBP1AACSM3 STOML2 POLR3DACTA2 UPF3A SLC31A1ACVRL1 CDC40 GPT2ADAMTS9 IPO5 MAP1LC3BADARB1 ARMCX1 C17orf107ADAT3 DNAJB9 IQSEC2ADCK2 TM9SF2 ZCCHC7ADH5 USP1 SERP1ADIPOR2 PDIA6 MANFADNP2 HSPG2 NPRL2ADORA2A SECTM1 SELENOSAGER ACSL1 SRPRBAGFG2 GPR89A /// GPR89BGOSR2AGO2 C7orf43 DPH2AGR3 FNDC3A SUPV3L1AIFM2 WDR12 VOPP1AIMP2 UNC50 TBC1D15AKIRIN2 ARCN1 NDEL1AKR1B1 CHMP3 /// RNF103-CHMP3KDELR2ALAS1 MICB TIMP2ALDH1B1 NMT1 USP36ALDH5A1 SLC28A3 MSTO1ALG12 PRKCZ SLC35E1ALKBH1 ISOC1 NCDNALPL FBXL5 NUB1AMHR2 CLK1 MPC1AMT TMX4 ADAMTS2AMZ2 CXorf40B ZFPL1ANAPC1 BCL2L2 SRP54ANGEL1 LSM12 POLR3EANGPTL6 UBE2D2 CNOT9ANKRD1 CYP3A4 EPB41L1ANKRD13BSRSF10 LOC728392ANKRD22 PCSK1 FTSJ1

Page 211 of 781 Diabetes

ANKRD27 MRPL3 ODF2ANKRD29 DHX29 PGM3ANKRD46 WDR61 PRNPANO1 BLOC1S5-TXNDC5 /// TXNDC5PGAM5ANTXR1 PSMD11 PI4K2AANXA3 SEC63 DHDDSAOC1 GPRIN2 NXT1AP1B1 PPM1A GOLGA3APBA3 COL16A1 PHF20L1APLN PIKFYVE NOLC1APOH SRSF6 CRIPTAPOOL MAPRE1 MAFBAPOPT1 PLAGL1 BSDC1AQP1 UBE2M PNO1AQP7 CAMKK2 TMEM41BAQP7P1 PPP1CC DNAJA3ARAP1 G3BP2 SEC13ARF5 TMEM70 RPGRIP1LARHGAP26CCDC47 CENPJARHGAP31LMBRD1 C11orf24ARHGAP39HOXA3 ATG13ARHGEF10LHSPE1 UFM1ARHGEF19 TMED10 SIAH2ARHGEF28 TMEM251 IMP4ARHGEF3 GABRP YRDCARL4C BET1 SNHG1ARMCX6 ECI2 NOL6ARR3 TOP3A MAXARRB2 SEL1L YTHDF1ARRDC4 ANKRD46 IFRD1ARSF RBP4 HSPA9ASPN MAP3K11 ZNF140ASTN2 TTC19 OGFOD1ATF7IP2 PEX2 PMM2ATG12 ATP5B TUBA1AATG13 TEX261 SRPRAATG2A ZNF518A CCDC149ATIC GAL3ST4 NAT9ATP5F1 LRRFIP1 TMEM263ATP6V1G2 PFN2 ATF6ATRAID HMGB1P12 /// HMGB1P12KDELR3ATXN7L3 SLC25A5 RIOX2B3GALNT2 NUCB2 HSP90B1B3GNTL1 ILF2 SCGNB4GALNT4 UAP1 UBE2BBAALC-AS2MCM3AP NARSBAAT CCL5 ATF3BACE1 DAP COQ10BBACH1 MBD1 OSBPL2BAP1 EEF1A1 ATG101

Page 212 of 781Diabetes

BATF3 AHCY BET1LBBS2 PIGT SELENOKBCAM SLC35B1 DNAL1BCDIN3D CEND1 RALABCL6 SLC9A6 ARMCX1BCOR CSNK2B KDM6BBDKRB1 C5orf22 EFR3BBEST1 CREB3L1 PNPLA8BFSP1 EMC2 CEP70BHLHE41 FZD9 TMEM39ABID VPS53 FARSABIRC3 NELFCD NRBF2BLCAP SGCE TMEM248BLMH EXOC1 OXNAD1BMP4 USO1 ZNF395BNIP3L AKAP11 TOP3ABPGM TMC6 ORMDL3BRCC3 PLCB3 SCFD2BRD4 MYH14 RBKSBRWD3 TMX1 TMCO1BSCL2 TNFRSF14 PCNX3BTBD9 DCTN6 NQO1BTN2A2 IKBKAP GOT1C11orf53 XPOT ALKBH5C11orf71 UBE2E3 POLE3C12orf60 ZNHIT3 MNTC12orf75 NSMAF INTS6C14orf105 CACNB1 RASSF1C14orf169 GALC SCD5C15orf41 PTGES3 BLZF1C15orf48 BEX4 ISG20L2C1orf116 ZNHIT6 COASYC1orf162 PTS GOLGA5C1QTNF1 ZFAND1 GSNC1QTNF3 GTF3C3 ZNF608C1QTNF6 OXSM BMFC1R MIS12 UCHL5C1S MBD3 GNL2C20orf96 GOLGA5 NEURL4C21orf62 GTSE1 HCG18C21orf62-AS1CCNF MAP1AC22orf39 IPO4 /// TM9SF1BCAS2C2CD2L KDELR2 EIF2S3C2orf44 ZNF358 LAPTM4BC2orf74 PRPS1 COG6C3orf18 CRKL DNAJC25C3orf67 UNC119B DDX50C4orf3 HAT1 TMEM104C5orf28 SUCO TSNC6 TSPY1 SRA1

Page 213 of 781 Diabetes

C6orf106 MIR6872 /// SEMA3BSEC16AC6orf223 ALG5 SCYL1C8orf59 SF3B1 ENGC9orf9 PIK3R4 ANGPTL2CA8 SRSF7 SDC2CABLES1 MKRN2 GZF1CAD DCTD TPMTCALHM2 SRSF8 GNL3CALML4 LOC101060321 /// LOC101060351 /// LOC101060376 /// LOC101060389 /// LOC102723859 /// LOC102724862 /// TBC1D3 /// TBC1D3C /// TBC1D3F /// TBC1D3HPPP1R11CARHSP1 MLH1 ETF1CASP5 ITGB4 GDACASP6 DLD LINC02693CASP7 PSMD6 TCF4CATSPER3 DESI2 ATAD3ACBX1 FGF16 ALDH18A1CC2D2A RSL1D1 CREB3CCDC102B TRMT5 GPR107CCDC112 NUP37 TARSL2CCDC113 DDX46 XPNPEP3CCDC117 ERC1 SGTACCDC121 GUCA2A BRIX1CCDC142 SH3PXD2A SENP2CCDC152 L1CAM C2CD2LCCDC189 RPE /// RPEL1GON7CCDC191 METAP2 DDX42CCDC34 POP7 FAM8A1CCDC43 CXorf40A GCC2CCDC6 EDEM1 SIKE1CCL2 CAPN7 CENPNCCND2 RABGGTB SLC35A2CCNI MUC3B TMEM120BCCNK C18orf32 /// RPL17 /// RPL17-C18orf32 /// SNORD58A /// SNORD58B /// SNORD58CYIF1ACD209 TUBG1 TULP3CD247 ANAPC13 GORASP2CD300LF USP16 TPD52L2CD302 FAM179B IPPKCD40 PPIP5K2 PPP2R5BCD7 SCUBE3 LONP1CD82 TMEM50A SEC63CDC16 PAICS STK19CDC25B RIN3 BBOF1CDC5L NECAP1 SF3A3CDCP1 SERPINI1 SMPD4CDH24 HMGN2 NOL7CDK8 NME7 CABP7CDKL2 TOMM20 DERL1CDKN2AIPNLTMX2 GTF2F1CDX1 MAST4 STX5CELF5 M6PR /// PHC1AKAP17ACENPBD1P1CST8 POFUT2

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CENPH SDHD BAG5CEP104 ATP6V1A MPHOSPH10CEP290 ENPP2 SELENONCEP57L1 AP2M1 E2F4CEP68 XBP1 SLC25A38CEP85 SYN3 ZNF263CFAP126 CUL1 RTL10CFDP1 PEX3 CDK2AP2CFI KLHDC2 TMX2CGB7 LMNA STC2CGREF1 NDFIP1 CHD3CHAD KLHL18 SRP72CHAMP1 SDC2 DPP9CHCHD4 C5orf28 ST5CHGA SLBP ZNF550CHI3L2 DTX4 TAF13CISH TJP3 EAF2CLDN15 TGFBR2 ERP44CLDN9 OR2C1 SENP5CLIC3 EED JMYCLINT1 SEP15 RPP14CLNS1A SEC23B UBFD1CLPTM1L PODNL1 TIMP3CLU PJA2 RAD1CLUL1 RBM23 GARSCMBL TXNDC15 MED10CMC4 BRD4 PCDHGC3CMTM7 HDDC2 WDR55CNDP1 PDGFB WARSCNGB1 SCGN CEACAM1CNN1 INTS12 ZNF70CNNM3 COPZ1 COPACNNM4 EPRS WNT4CNOT10 CUL3 DEDD2CNPY1 HPRT1 SETD1ACNPY4 PTPN3 FAM177A1CNTNAP2 DMXL1 ZNF229COA4 CNBP SKIV2LCOBL HTR4 CDR2COG2 SEMA7A WIPI1COL12A1 ZAP70 GOSR1COL15A1 CPNE3 P4HBCOL1A1 TFR2 ZNF462COL1A2 RAB1A GAKCOL22A1 PPP1R12A TRIM24COL4A1 MAGEA10 CEP104COL4A2 SLMO2 JADE2COL6A6 PGRMC2 PPRC1COPE NAP1L2 HERC6COPRS ASF1A DCUN1D5

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COQ10A SERPINB13PPP1R15ACOX18 PLEKHA4 KPNB1CP SELT PSMC4CPT2 CALCOCO2 TOX4CPXM1 ARFGEF2 COTL1CREBBP SUCLA2 METTL7ACRHR1 SUCLG2 PCMT1CRIP3 RBBP4 SAR1ACRLF1 UBL3 CHST11CROCC RPL6 BAP1CROCCP2 UBR7 GOLGA2CROT OR10H1 VPS53CSF1 SSR1 PDX1CSF2 APBA2 ELP2CSF3 PPP2CB SLC30A7CSTB RFC3 TMEM131LCTBP1-AS2 NPTN SLC10A7CTGF VDAC1 DNAJC3CTHRC1 CRY1 CEP95CTNNBIP1 ERN2 IFT20CTPS2 RND2 SLC39A7CTSC PGRMC1 SLC4A8CTSF PEX11B ZFAND2ACTSLP2 CAT DPAGT1CTSV TTC37 FGFR1OPCTSZ NT5M CALCOCO1CUL4A DHRS7B ALDH1L2CWF19L2 BCL2L13 SRRTCXCL1 PRKACA TIMM44CXCL2 SARS IRGQCXCL3 SAR1A ZNF331CXCL8 UCHL1 PITHD1CXorf40A RSL24D1 DESI1CXorf40B ANP32E ZNF37ACYB561D2 SRPR SNNCYB5R2 SBF1 NAA35CYB5RL SEH1L HM13CYP24A1 TMED2 MAFACYP26B1 ARGLU1 KLHDC10CYP2R1 KLHL28 ZNF622CYP39A1 SMC3 TOMM5CYP46A1 CX3CL1 EBLN3PCYSRT1 MARS /// MIR6758GJD2DAAM1 PSMB5 GCC1DALRD3 FANCC TCAF1DBNL SH2B2 LLGL2DBP NUDT7 TRIM27DCAF17 ZNF343 ZNF791DCAF4 DVL1 SAR1BDCAKD ZNF22 FXR2

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DCLK3 IGF2BP2 ZSCAN12P1DCST1 ARFGAP3 SBDSP1DCXR SRPRB ALG5DDR1 MAP2K4 MEN1DDX20 C11orf58 PLEKHG3DDX42 SSTR3 NDRG1DDX51 MON2 RECQL4DEAF1 PRKRA UBIAD1DEFB109P1PLEKHF1 DNTTIP1DEFB4A FGF17 ARL1DEPDC7 IL3RA RASSF5DHRS4-AS1ERH ATF4DIAPH2 ENPP4 ZNF131DICER1-AS1SLC35G2 DNAJB11DIMT1 GRIN1 LARP1BDIS3L DCK ACVR1BDISP1 KIFC1 PNPLA2DIXDC1 CCT4 HSP90B2PDKC1 LOC101928278DDX21DKFZp779M0652ARPC1A ATP6V0E1DLEU1 ZNF473 NOCTDLGAP1-AS1DHX15 DCAF13DMGDH WFDC2 GPD1DMKN PSMA1 AFTPHDMRTA1 RNF113A TUSC2DNAAF2 TAF2 ARIH2DNMT3B RPS2 /// SNORA64ETV5DOCK4 LARP1 SLC37A3DOPEY2 EPX CUEDC1DPH5 RPL4 /// SNORD16 /// SNORD18A /// SNORD18B /// SNORD18CIKBIPDPY19L2 PDCD10 SMYD5DPY19L2P1PFKM MOGSDPY19L3 MRPL22 RPS6KC1DSEL CHUK FARSBDSTYK ALMS1 ELMO1DTX2P1-UPK3BP1-PMS2P11RPL10A RIN2DUSP10 GORASP2 NADK2DYNC2LI1 SHOC2 SART1DYX1C1 PCBP4 FNTAEARS2 E2F1 SLC7A6EBI3 LILRA4 WDR45BEBPL ACP1 ABLIM1ECEL1 NEBL PYCR1ECHDC1 BAG2 RBM28ECI2 PNMA2 CBX4EDA2R LOC732360 /// TDGPYGBEDN2 MPC2 ROCK1P1EDRF1 PEF1 FICDEFCAB7 RPS6KC1 SBDSEFEMP1 RECQL4 IL20RA

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EHHADH RRAGA ZNF165EIF2AK4 RALGAPA1 /// RALGAPA1PCCNKEIF4A2 RNU86 /// RPL3 /// SNORD83BPPIEEIF4EBP3 RWDD2A MBD1EIF4G3 SERP1 SLC2A4RGELK4 SCP2 C6orf62ELMSAN1 SRP54 PLVAPEMC3 AZIN1 HYAL2EMC7 VLDLR MAATS1EMP1 CLTCL1 USP48EMP3 ARVCF SEC22AENC1 ZDHHC4 ARL2BPENDOD1 RHOA OLFM2ENO3 AMZ2 ETV1ENPP5 TEX2 EBPLENTPD2 DNASE2 STX18EPAS1 CENPC CCDC9EPB41L1 CPE ASCC2EPB41L4A CCDC15 AP3D1EPDR1 TFB2M DUSP12EPHX2 PHB CNPEPOR FAM208B RAB18EPS8L3 RAD54L ESCO1ERAP1 PRDX3 ATG4AERI2 TMEM14B TTC17ERO1A PRPSAP2 SEC61A1ESYT1 RAB6A /// WTH3DICAMLGETV3 EAPP MAF1EXD2 ERGIC2 STK40EXOC3L4 RBM7 TRMT6EXOSC8 RBM39 HLA-EEYA2 KATNB1 YPEL4EZH1 SNX24 PRKAR2AF12 RHEB SAE1F2R PYY2 ZNF222FAAH TNFRSF13BSEC23IPFAM104B PSMC3 AENFAM110B KIR3DS1 ZNF587FAM110C TVP23B ATP2A3FAM117B CUL5 RNF40FAM120B ADSS ELOVL5FAM122C ZNF646 DCUN1D3FAM133CPSDHB L3MBTL2FAM136A HAUS2 ATXN7L3FAM156A CYP2C8 LSAMPFAM168A LOC101928747 /// RBMX /// SNORD61CEP76FAM172A CYC1 COG1FAM182B TNNI2 ZXDCFAM198B GJC2 PLCG1FAM19A4 OSTM1 EDC3

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FAM217B TBPL1 UBTFFAM220A DCAF15 ANKRD42FAM24B CRYBB3 RELAFAM35A ENOPH1 FAM160A2FAM53B PSMB7 TFGFAM66A CLNS1A SHMT2FAM86B1 NUP205 LOC107105282FAM86DP SIGLEC7 MEIS1FAM95B1 FBL H3F3AP4FARP2 MFF KRT10FBLN1 PRKAG1 SCML1FCAMR SUN1 FBXO25FCER2 PCNP VWA1FCMR POU5F1 /// POU5F1B /// POU5F1P3 /// POU5F1P4WDR24FDXR MUSK ACBD3FERMT3 C5orf66 ARHGEF3FEZ1 HCRP1 ACLYFGF11 DNAAF1 RHOQFGF2 CMKLR1 TBC1D24FGF9 HNRNPH3 QRICH1FGR MAPRE3 UBA5FHOD1 CNIH1 MMRN1FHOD3 WIPF1 CWC25FIBIN HMGCR ZNF526FKBP10 MPP6 CXXC5FKBP7 FKBP10 UBR7FKBP9 CCNG1 POLR3AFKBP9P1 LETMD1 TRMT1FLJ16779 EMC7 YY1FLNC CALU RAB5AFLT3LG AIPL1 TGDSFMO1 RNGTT ZNRD2FMO3 PPP3CC CD82FNDC3B RPL7A /// SNORD24 /// SNORD36A /// SNORD36BBMP5FOLR1 PCDH1 POLR2CFOXJ2 DHRS7 ANP32AFOXO1 CKLF LINC00261FREM1 SCG5 CNOT10FRMD3 TMEM135 DPH7FRZB FAM106A SLC30A5FSCN1 ZZZ3 ACP1FUCA2 IRF7 INPP5KFUK NDUFB8 FAM156BFUNDC1 CREG1 NOC4LFUOM SLC25A11 MAGOHFUT1 PRIM1 MTORFZD1 NME1 EIF2AK3G0S2 PGD ZNF384G6PC2 LTN1 ELMSAN1G6PD PPP2CA ZNF805

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GABRE ME2 STT3AGADD45A MTPAP SMAD7GALNS CYP21A1P /// CYP21A2GRPEL2GALNT12 GNAS WDR74GALNT4 COPA SEL1LGAMT TAS2R9 ESRP1GAPDH RPL7 DCAF10GAS1 OAT CHD1GATAD1 MTMR6 LRRC47GATC LIPT1 MACO1GBAS LENEP SLC16A2GBE1 MTO1 TMF1GCLM STARD13 ZNF664GDF6 SLC22A2 GPAT3GEMIN5 GATC /// SRSF9TOPBP1GEMIN6 WDYHV1 SNHG8GEMIN8 SNX4 TMED2GGCT GFER SNIP1GK TMED7 /// TMED7-TICAM2DPM1GK3P PRKAR1AP /// PRKAR1APWSB2GLIPR1 WNK1 CASRGLRX ADIPOR2 ERCC5GLS2 CASZ1 PIAS3GM2A RPL12 NANSGMPPB BMP10 AKT1S1GNGT2 BEX1 TAF1DGNRH1 MEAF6 COA7GOLGA6L9MDH2 DIABLOGOLGA8CPWISP2 AMPHGOLGA8G NEFM TLE3GP6 STMN2 MGST2GPC3 FLJ11710 CCDC113GPN1 GNL3 /// SNORD19BRNASEH1GPR155 RABGGTB /// SNORD45A /// SNORD45B /// SNORD45CIPO4GPR37 DCTN3 MIGA1GPR84 GATA1 THBS1GRAMD3 SEC14L4 ATG3GRAMD4 CD164 ARFGAP1GREM1 CTBP2 PSMD5GRID1 PLXNA1 GBF1GRIK1-AS2 ALDH4A1 C22orf42GRIP2 RPL30 FBXO33GRK6 CLCN3 NUS1GSTA4 SLC30A1 SLC35B1GSTM2 TMEM165 MKNK2GSTO2 CRYGC KLHDC2GTF2E2 ZIC1 APBB3GTF2H5 CD248 NSUN2GTF2IRD2 CAPRIN1 RABGEF1GTF3A SKIV2L2 ERICH5

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GTF3C3 MTX2 RAB31GUF1 RNF13 SBF1HABP4 RAPGEF3 ZNF827HAS2 RIOK2 GM2AHAS2-AS1 SEC23IP ID4HAS3 PSMD5 PES1HAUS1 PAFAH1B1 PPIL6HAUS4 KIFAP3 MAGT1HCK ABCE1 LOC642366HDDC2 IDH3A PARP2HEATR6 YTHDF3 PKMHECTD1 LMBR1L REEP4HEMK1 UNC93B1 EIF1HEPH EXD3 NUP58HEXB RAB14 FBXO8HGSNAT AGPAT5 RINT1HHAT CTR9 SEC22B2PHIBADH KCNA10 SEC22B3PHIBCH BTK PLPP5HIF1A EEF1B2 /// SNORA41PELOHILPDA GLI1 EDA2RHIST1H2ACSH3TC2 C1QL1HIST1H2BCGLO1 PLEKHA6HIST2H2AA4C12orf5 GOLGA1HIST2H2ACPOLE3 GPN2HIST2H3A PARP2 CFAP44HIST2H4B C16orf80 SMIM14HK2 AP5M1 PLK2HKR1 ARHGEF1 /// LOC100505585TRERF1HLA-DQB1CYP2B6 /// CYP2B7PPUS1HLA-DRA SLC45A2 DPYSL3HLA-DRB5 TOM1L1 NAV1HLA-J AK6 CCDC174HMCN1 PNMA3 COPS3HMGB2 DHX35 ISCUHMGN3 ENTPD3 BCL2L1HNRNPC RNF138 ALG2HPD ACAD8 CARSHSD11B1 ACADM MIA3HSP90B1 ZBTB7A LAMA5HTR3A COPS5 EIF1ADHUNK SERINC1 CDKN1CICAM1 RAB6A /// RAB6C /// WTH3DICOX7A2LICAM4 PRDM2 IMPAD1ID1 SGPL1 PDIA4IDH1 MANF RNMTIDO2 CLIP2 BOD1IER3 TAPT1 URB1IFNAR2 PSMD10 NEO1IFNGR1 PAX9 LOC100419583

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IFT172 KCNJ9 CDC23IFT46 OSBPL8 NSMFIFT74 TRMT11 RNF41IGFBP3 LGR4 USP14IGFLR1 UBA5 TNFRSF21IKBKAP PSMD8 ZNF275IKBKE KCTD3 TBC1D23IL12RB1 PNOC TMEM19IL15RA C1QTNF1 GFPT1IL17C MRPS22 TBL2IL17D AMD1 RIOK2IL17RA ZNF408 TMEM208IL18R1 MAGEB2 ELP5IL1A ARPP19 H2AFYIL1B HSPA14 SEMA4BIL1RN ZNF587 TSR1IL23A FUT3 SAMD11IL24 JUND LPCAT3IL27RA MLLT4-AS1IER3IP1IL36G ATP6V1B2 MBD4IL36RN SLC25A32 TMEM150CIL3RA AK4 /// LOC100507855BORAIL4I1 ALOX15B PRKAR2BIL5RA FBXO11 PLEKHA3IL6 IMPA1 CHAC1IL7 PTEN /// PTENP1ZNF202INHBA PPP1R13L DYNLL2INSL3 TGFB1 DLL4INTS3 ACSF2 GLRX5INTS6 MIR636 /// SRSF2EMDINTS9 DYNC1I1 LINC00888IP6K2 CDH8 YKT6IPO5 FBXW12 UPF2IPP SIX1 CEP68IQCC CST4 PALM2-AKAP2IRAK2 GMFB SLC25A44IRAK3 GIN1 YIPF5IRF5 TNFSF14 MAGEH1ISCA2 HMG20A SIX2ISLR MINPP1 SEC22BITFG1 COL2A1 CTDP1ITGA7 REXO2 INO80ITPRIPL2 LCK MZT1ITSN2 CADM3-AS1YARSIZUMO4 HERC2 /// HERC2P10 /// LOC101929047 /// LOC101929832LTV1JAK3 STAT5A BRPF3KANSL1 GLT8D1 DERL2KAT2A PDHX TAX1BP1KCNAB1 CNGB1 RSL24D1KCND1 NOL11 TMEM173

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KCNG2 SOGA1 PREBKCTD10 RAB28 PSMD8KDELC1 MAN1A1 PHKG2KDM1B AC003989.4EIF3GKEAP1 KIAA1614 EXD2KHK TSNAXIP1 ARPIN-AP3S2KIAA0101 MAK16 LRIF1KIAA0319L CCL7 TBC1D10BKIAA0753 BCLAF1 DHRS2KIAA1549L S100A1 PNRC1KIAA1804 PVRL2 SLCO3A1KIFC2 TRIM62 TFB2MKIT LPP ZNF639KITLG TUBB BCKDHAKLF12 MED6 LIG1KLHL12 HYAL3 OSBPKMT5C PTGER1 RBM8AKRT79 ZBTB1 ECE1KYNU BST2 NKIRAS2L3MBTL1 MAPRE2 BUD31LACTB2 KCNJ13 RASD1LAMB1 CBX8 MRPL3LAMB3 DDX1 SEC24ALARS PSMD7 RBM39LBH BMPR1A ING1LDB3 CHMP1A SLC25A32LDLR OXA1L CNOT2LEAP2 TSN CADM1LGALSL CEP63 ZCCHC17LHX5 PANK3 LRRC20LIAS ADAM15 BMPR2LIF DYNC1LI1 ARHGAP24LILRA5 GPX7 FAM98ALIMCH1 FASTKD2 CHCHD7LINC00176 MPC1 PRPF19LINC00339 PRKRIR RER1LINC00473 NDE1 LAMTOR3LINC00602 ZFR YWHAHLINC00930 ARAP3 SLC44A3LINC01106HSP90B1 /// MIR3652SF1LIPA CLP1 SIX3-AS1LIPG MYH13 COPG1LMTK3 UFM1 TM9SF2LMX1A EHD2 RNF145LOC100289673LARP4 MCFD2LOC730101LILRA3 SSR3LOC81691 C6orf211 DNAJB9LOH12CR2 ARID1A C9orf72LRFN4 ZDHHC6 DYNC1LI2LRPPRC PTCD3 BBS9

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LRRC20 SIM2 STAMLRRC27 CHIA PLCH1LRRC32 GCSH /// LOC101060817THOC3LRRC8D MAP7 SORBS2LRRN1 TCF7 IFIT1LSG1 BDKRB2 CLUHLTBP1 SLC12A7 PIKFYVELTBP2 HNF4A GLULLYN MED17 WDPCPLYRM1 ZSWIM1 ATP6V0A2MACROD2 EIF2B1 DCAF1MAFF UBE2G1 TRIM4MAGEE1 RDX RAP1GAP2MAN1A1 ABCB1 /// ABCB4EFHD2MANBA OGT UBE2MMAOA IRF5 FAM227AMAP2K3 SREK1 GDAP2MAP2K6 CD52 ARL4AMAP3K8 RAB2A COX19MARCO TMEM9B ZNF618MAST4 CYTH3 CLCN6MATN2 PREPL HIBADHMBIP ADNP CYP2R1MCAM TRANK1 SRRDMCEE DAD1 SNX5MCM6 SCFD1 SYAP1MDH2 CYP3A5 DDA1MED18 COG5 EPSTI1MEF2C RWDD1 ALDH6A1METTL5 PPT1 NDST1METTL7A EFR3B ZNF667METTL9 UFC1 THAP9-AS1MFGE8 TSPYL1 ARL14EPMFSD2A CCSER2 SUPT6HMGARP POLR2B CHDHMGC12916PLEKHA6 SDE2MGME1 KCNJ10 MED8MGP SUGP1 SMG5MICB NRBF2 TIMM10BMIF4GD PANK4 RTRAFMIOS VAMP7 SDAD1MIR146A LECT1 SPATA2MIR22HG CD46 ESS2MKS1 LAT ABHD5MLNR RPLP0 UAP1MMP1 ANP32D PITPNM2MN1 ALDH9A1 SLC30A4MPL PIP4K2C ISCA1MPLKIP OR10H3 GOLGB1MPP7 SS18L1 NOTCH3

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MRGPRX3 CMAS XPOTMROH6 CCZ1B MAP3K6MRPL14 DNAAF2 MTA3MRPL19 NOD1 CCSAPMRPL24 MRPL17 ARHGAP39MRPL30 TXNL1 PRPF18MRPS27 PCBP2 TMEM243MRPS9 DDX5 /// MIR3064 /// MIR5047ABCC8MSC CABP2 IFIT5MSC-AS1 MUC2 TMEM198MST1R MIR1236 /// NELFEHNF4AMSTN MARCH8 DDX18MSX2 CLCNKA /// CLCNKBCOL6A1MTAP NEK7 N6AMT1MTERF2 ATF1 MRS2MTERF3 TMEM140 BHLHE40MTFR1L RPS3A /// SNORD73ASYNPOMTG2 SEC24B C19orf47MTIF3 CHRNE WDR43MTPAP CCL25 SEPTIN8MUL1 KLHL9 SEPHS2MUSTN1 PIGP GATAD2AMXRA8 MYH8 B4GALNT3MYO1B MED24 WDR19MYO1D DERL2 BHMT2MYOZ1 COA1 DNAH5N6AMT1 CHGB C15orf48NAAA CIC CNTRLNAB1 SPI1 CLPPNAMPT COPS6 ISOC2NAPSA CYAT1 HDAC1NARS RTCB RAB39BNBEAL2 SLC35E1 ANKRD11NBPF1 SNX2 SYKNBPF10 COX7A2 TP53NBPF11 MRPL13 LOC100630923NBPF14 HSP90AB1 LYSMD3NBPF15 CREB3L2 GET4NBPF3 KPNA3 INKA2NCAM1 COPS2 POLR1BNCF1 HSPA2 SELENOWNCF1B CMAHP MRPL2NCF1C GIT1 PSMD12NCKAP5 CPTP PIP4P1NCOA6 TMPRSS5 ZW10NCSTN MAP4K3 DYMNDST1 NR3C1 HCCSNDUFV2 SUPT4H1 RAB36NEK3 LZTFL1 RANBP10NFATC3 NBPF1 SRP68

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NFIA ATP8B1 AOX1NFKB1 PYROXD1 FOXO4NFKB2 COPB2 GPANK1NFKBIA ACTL8 EIF3BNFKBIZ GPR124 EIF4HNGF RBM12B-AS1SYS1NID1 CNN1 TSC22D1NIPSNAP1 SERHL /// SERHL2ERGNLN ANP32A SUCONMNAT1 ARFGAP1 UPRTNMT2 C22orf31 KIAA1211LNMUR2 BLCAP SORDNOA1 CD4 FOXK2NOCT PLEKHG3 AP5Z1NOD2 HSPA12A CXorf40ANOSTRIN MYO7A USP37NOV PPBPP2 PACRGLNPC2 CCDC87 SMAP1NPHP1 MAN1A2 CCZ1BNPM3 SMO LTN1NPTXR ST3GAL4 SPTY2D1NQO1 ZNF706 DNAJC10NR1H3 UBE2A CDK13NRBP2 PCBP1 RARS2NREP RANBP2 MDH1NRF1 PDE9A NECAP1NRG1 SPRED2 MED26NRG3 CDC37L1 ZNF770NRN1 MOG SDF2L1NSMCE1 SIPA1 EPB41L4A-AS1NSUN6 NDUFS3 DNAAF5NTAN1 INCENP SLC35F6NTM CDA UBE2J1NTN5 GPR21 PDE9ANUDT16P1HNRNPH2 /// RPL36A-HNRNPH2TYW3NUDT5 CDK4 SULF2NXN EIF4E COA8OARD1 EGOT TRMT61AODC1 ARPC5 MLECODF3B RPL23A /// SNORD42ABRPF1OGFRL1 HIST1H3E ABI3OGT API5 NELFEOLA1 WAC PPAN-P2RY11OLFM4 EIF1B EXOSC1OPA3 LOC729966 /// PDE4CAP1M1OPCML PAPSS1 ARPINOR2A1 PLEKHF2 APBA3OR51E2 UBE2Q1 PRSS23OSBP SEC13 DDX46OSBPL1A CAND1 REXO4

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OSGEP ZCWPW1 PRICKLE2OSGEPL1 MRPL49 DNAJC9OSM ATP11A ZNF547P2RY13 CROCCP3 GCKPABPC1L NCBP2 DERL3PADI2 SLC25A3 UTP25PAK7 CRH RRN3PALB2 SOX2 HDLBPPANK1 SLC30A9 GLT8D2PAPD5 HLTF BAHCC1PAPPA KCNQ1DN SPATA17PAPSS1 HIRA CERS2PATZ1 UCHL5 PRKAB2PAXIP1-AS1ZNF696 CRELD2PCBD1 CITED2 CHERPPCDH15 PTDSS1 ERLEC1PCDH18 PVALB LLGL1PCGF6 SH3BP2 BLCAPPCMTD1 TDP2 PTPRJPCYOX1L KRT33B LIN52PDCD4 ELL2P3 /// ELL2P3MIEF1PDCL MAFB SPTBN2PDCL3P4 SPC24 TVP23C-CDRT4PDE4B SRP9 DHX57PDE9A NTSR2 F2RL3PDGFRL PVRIG HS6ST1PDZD11 APOC1 TOMM40PEBP1 PAWR MCPH1PELI1 ANKRD49 MSTO2PPEX1 PML FUT8PF4V1 EIF4H ABCB8PFDN1 RFX5 RBM47PGAM4 CCDC9 LOC652276PGAP3 TCEB3 FAF2PGK1 GDI2 MAPK8PGLYRP2 ELOVL5 WRNPGM2 KIAA1654 PRELID1PHF8 KRT8P11 /// KRT8P11CYGBPHLDB1 IGKC /// IGKV1-5 /// IGKV1-5 /// IGL@ARV1PHYH GPATCH2 EPRSPID1 CCR5 MYRIPPIM2 ACAT1 MIS12PITPNA-AS1CTF1 ODR4PITPNC1 ALG9 RAB3BPITPNM3 BTBD3 MESTPKM PEG10 TTLL11PLA2G12A OCM2 TPRG1LPLAT TRADD TMEM64PLAUR LOC339166 /// WSCD1RMDN3PLCG1 MC1R NR4A3

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PLD2 RPS3 COG5PLD6 TOR1AIP1 NCAPH2PLEK2 CD177 PLXND1PLEKHM3 HSPB6 HCFC1PLPP3 LANCL1 HIC1PLSCR1 LRP1 EIF5PML ORC3 C1orf52POFUT1 DLK1 CXXC1POLA2 KCNH4 OSER1POLH SGMS1 NVLPOLR1B C6orf48 ZC3HAV1POLR1D PCNXL2 NLE1POLR3GL KRT20 AGO3POMGNT2 RAD21 PPATPOMT1 ALG11 /// UTP14CMRPL49POU2F2 MRPL39 KDRPPFIBP2 IDH3B ZNF529PPIP5K2 LOC101928625 /// MED21CENPBD1P1PPM1H PRRC2A GPATCH1PPP1R12B AGRN GIPC1PPP1R32 TOB1 CCDC59PPP2R1B CXCR3 YIPF2PPP2R2D DUX1 /// DUX3 /// DUX5SPSB3PPP2R5C MEST ALDOCPRELP FNBP4 EBNA1BP2PRIM1 C12orf29 ARL4CPRKAA2 SYDE1 PCDH7PRKAB2 MIER2 XYLT2PRKAG1 PSMC2 C11orf95PRKCH G3BP1 NDUFS1PRMT3 POLR1B ACVRL1PROS1 TSPAN7 DBNDD1PRSS35 MRPS30 CRLS1PRSS50 EDC4 COG3PSD3 PADI3 TMEM26PSMA5 CPLX3 ATG2APSMA7 LSM14A TEX261PSMC4 RNF130 PAFAH1B3PSME3 FAM208A PRMT5PSMG1 JOSD1 GNG2PSTPIP2 NIF3L1 KLHDC8APTAFR GZMM TM7SF3PTGES ATP5G3 ZNF542PPTGS2 SET /// SETSIPTHUMPD1PTK2B STAG1 UBA6-AS1PTPN18 CKAP2 /// IGLC1 /// IGLV1-40 /// IGLV1-40 /// IGLV1-50 /// IGLV1-50ORC3PTPN6 URI1 KLF15PTPRO NUDT9 RXRAPXDN TMEM212 ABCF1R3HDM4 SLC8A1 CTU2

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RAB11FIP2 ACAP2 PRPF6RAB20 RUNX3 EVI5RAB24 GLB1 /// TMPPEPARP9RABGGTB PMF1 MGAT1RABL2A NPVF PMS1RABL2B FYB LMLNRAC2 GPD2 PLAG1RALGAPB C2orf47 ZNF570RALGPS1 NPEPL1 ZSCAN2RAMP2 LOC729164RABL2BRAP1GDS1PSMB3 PTMSRAPGEF3 PPP1R2P9 NREPRARRES1 PLP2 GTPBP2RASD1 PRKCH MRPL55RBAK CLUHP3 PITPNC1RBM12B SSR3 RAB6ARBM33 FAM13B PRELID3BRCE1 NGB SAMD1RDH10 DDR1-AS1 OXCT1RELB KLF11 GAR1RELT SLC2A14 /// SLC2A3PITPNM1RGS5 IRF4 NUDT21RHBDF2 NR4A3 CTSORHCG EFS DCUN1D2RHOA LRBA NKX2-2RHOQ GSTA4 ACO2RIMBP3B MASP1 FAN1RINL NUP93 TMEM37RIPK2 KIF5C ANKS3RIT1 NRGN IBA57RNASEH2B ANGPT1 TMEM184ARNF149 IFNB1 REXO2RNF168 SLC16A8 PITPNARNF170 SCML1 ZNF473RNF19B CKS1B RTL6RNF24 ID4 DRG1RNFT1 IDE ATAD3BRNPEP HOXC8 SASS6RORC GTF2H3 LRRC32RP9 C1QBP TAF5RP9P AK6 /// TAF9MARVELD3RPL17 CST3 LDLRAD4RPL23AP53PREB TBC1D10ARPL34 SPATA5L1 GON4LRPL5 MTR MTPAPRPP30 SC5D FUCA2RPP40 ALDH1L1 KLC4RPS3A TMPRSS3 ZNF3RPS7 KIAA1279 MKRN2RPSAP58 MAZ MIB2

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RTCA MUC3A /// MUC3BPSMD3RUNDC3B ANKMY2 GRASPRUNX1 STAM GPR4RUNX3 POLQ TXNL4BRWDD4 AIFM1 NAA15S100A9 TNFRSF1B COPS2S1PR1 MTUS2 TMEM167BSAA1 ZBED5 TSPAN13SAA2 PPFIA2 ZFAND1SAA3P PCNA PCYT1ASAA4 NBEAL1 /// RPL12DSN1SAC3D1 COPS7A CYP27A1SAMD13 DDX51 VSTM2LSARM1 CCR3 TRAPPC10SATB2 SMNDC1 TSPAN9SBNO2 STARD5 ARSDSCARF2 COIL NKAPSCD5 KCNAB3 GOLPH3SCFD2 KPNA6 ELP1SCGB1D2 LBP GOLT1BSCO1 CALM1 /// CALM2 /// CALM3TMEM132DSCRT1 CNOT8 BUB3SEC24A PSMD14 PRKAB1SELK CARD14 MPV17LSEMA4B MAPK8IP3 EIF3FSEMA4F KRT2 MTHFD1LSEMA6C ENDOD1 SMAD9SEMG1 TSR1 SEMA3FSEPP1 UBA2 NUBP2SERAC1 ARPIN AKTIPSERPINB7 KIZ NIPA2SERTAD1 ZNF287 SNHG16SETD3 GABRR2 EEF1AKMT4SFR1 FLJ42627 MIR22HGSFRP5 WT1-AS FLT1SFXN3 MYH3 WNK2SGCZ LINC00563 LINC02593SGK2 CNPY4 DDX51SGMS1 MEGF6 CDC37L1SGPP2 SLC24A2 GPX2SH3BGR SEPT10 NOP58SH3PXD2B C8orf33 KRBOX4SHC1 WFDC1 ZMYM3SHISA5 ETAA1 C12orf29SIAE PDHB LINC00365SIDT2 WDR47 JUNSIGLEC14 ADAM19 KLHL5SIL1 TMED3 MYT1LSIRT3 CCNB1IP1 FBXO4SIRT5 LAIR2 TRMT2A

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SKAP2 LAMTOR3 PDE12SLAMF1 RAB11FIP2 DLG2SLC11A2 CACNB3 MSRB2SLC16A2 BRF1 DOCK6SLC16A3 RP11-10N23.4GOLPH3LSLC17A4 CCPG1 /// DYX1C1-CCPG1DIS3SLC17A5 PAM ZNF417SLC1A3 TOX3 UBA6SLC20A1 ANKRD10-IT1FEM1CSLC22A4 RUSC2 SOCS7SLC22A5 IGLV4-60 /// IGLV4-60ZPR1SLC23A3 OSBPL10 EEPD1SLC25A15 TERT EPB41SLC25A21-AS1LRRC20 TMEM67SLC25A27 PDCL3 /// PDCL3P4PAICSSLC25A36 DOC2A UTP11SLC25A43 MAMLD1 IDH3ASLC25A51 TMEM59 TIAM1SLC27A1 EEF1E1 HGSSLC27A4 RNF139 SS18L1SLC29A2 HERPUD1 CA4SLC2A4RG HLA-DMB IFT80SLC2A6 MAGI1 MEX3CSLC2A8 KCTD17 PDGFASLC31A2 RIOK3 PAQR8SLC34A3 CANX VARSSLC38A3 CRTAC1 RNF126SLC39A10 DPP8 B3GNT8SLC39A14 TMED5 FLOT2SLC3A1 PSMG2 RANBP1SLC40A1 LOC101928378LCMT1SLC43A2 SLC25A17 GTF2F2SLC46A1 RGS12 RAB15SLC46A2 RPL11 FEN1SLC4A11 LY6D PTK7SLC6A14 GOLGA2P5ZNF674-AS1SLC7A11 CHKB-CPT1B /// CPT1BWDR36SLC7A5 GOLIM4 GRIA4SLC7A5P2 GPLD1 SLC2A12SLC7A9 SLC26A2 YIPF4SLCO4A1 RAP1GDS1LRRC1SLCO4A1-AS1CYP4F12 EFL1SLMAP C14orf1 BOD1L1SMAD7 C21orf2 SNCBSMARCA1 PPP2R5C HHEXSMC3 NRCAM CYB561D2SMIM19 SKAP1 GNA11SMIM3 ANXA13 PTRH2SMIM8 POGK MMRN2SMOC2 FAM8A1 ARHGAP5-AS1

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SMYD3 DCSTAMP DPH3SMYD5 RHOBTB3 EMSYSNAPC2 TRAM1 TMUB2SNAPC5 MYL1 IRF2BPLSNCAIP FAM96B TRMT112SNHG1 CHRNA2 RIOK1SNHG8 ADARB1 MORF4L2SNORD76 SEC61A1 PRR15LSNPH MRPL19 TXNDC12SNUPN DNAI1 PIP4K2BSNX17 VPS26A TMEM14ASNX5 SHC1P1 /// SHC1P1KMT5CSOAT2 TMEM126BTRUB2SOCS1 MFAP3 GOLIM4SOCS3 NR2F1 /// NR2F2LAMP3SOD2 ADAM29 /// LOC101928551SNHG20SORBS3 VPS4B HIP1RSOX13 PAXBP1 GAD2SOX8 IFT52 PLEKHG2SP6 APOBEC3C HSPA14SPAG8 MAP1LC3BZNF347SPARC POLDIP3 /// RRP7BCLEC1ASPATA32 PAX2 MIR210HGSPEF2 LAMA4 CADPS2SPIN2A ERC2-IT1 TSSC4SPIN2B GCC2 MXRA7SPOCD1 TPD52 CALRSPOCK1 RPS15A TAGLN3SPRR1B KHDRBS2 LRIG3SPRY4 SEPT5-GP1BBINPP5ESQRDL PPP6R1 KDM7A-DTSRA1 LRRC61 YME1L1SRD5A1P1 TPRKB PRKCDSRGAP3 IGKV1-37 /// IGKV1-37 /// IGKV1D-37 /// IGKV1D-37DDIT3SRSF6 DHX34 SUPT5HSRSF8 RALGAPA1SLC33A1SS18L1 KIAA1751 COPB1ST3GAL1 GFPT1 RNPS1ST3GAL4 CXCR5 CEP57ST5 FHL3 CDKN2AIPST8SIA2 SMG8 LAMB1STAT3 CRX CXCR4STC1 ETFA WASF1STC2 ERICH1 MINDY2STEAP1B TAS2R16 RBM27STIM1 SEMA3F ERVK3-1STMN1 CCT7 PTPRHSTOML1 CRNN KAZNSTOX2 ORMDL2 CMC2STRADA PSCA GPR180

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STRBP ITGA9 ZFP3STX11 EIF2S2 SLC18B1STX3 VDAC2 LAMA1SUDS3 HSF2BP OSGEPL1SUGCT ASAP3 MAOBSUMO1P1 GAK VPS33ASUPT6H PRMT5 SLC26A2SVEP1 OSBPL9 DUSP11SYNDIG1 CRHR2 POLD3SYNJ2 TSKU TCF7L2SYNM ENTPD2 CABLES1TACR1 NPY6R BET1TAF11 FCF1 /// MAPK1IP1LNABP2TAF1D PGLYRP1 NHP2TAF5L CRIP1 DNAJC5TAGLN BTNL8 KLF7TAMM41 GABARAPL3OTUD5TANGO2 GPR63 PRELPTAPBP YBX1 COPB2TBC1D4 SSX3 CDKAL1TBX3 STAG3L3 MRC2TCAF2 BCAS2 CCNT1TCEA2 VBP1 PAGR1TCEAL4 BTAF1 ATP8B2TCEAL8 LOC101930324 /// NSFDYRK4TCHP IL25 KAT8TCOF1 ALKBH1 SELENOITCP11L1 TARP MLH1TDRD3 LOC101929304 /// SNX29ZNF283TESC RAB5A LEMD2TEX2 SMPDL3A SETD7TFAP4 LOC101060521 /// POLR3EHSPB6TFE3 COL9A1 SLC30A6TFPI2 OR11A1 C16orf46TGM2 TARS TMEM229BTHAP12 GPR153 AHDC1THBS1 CRLF3 NEGR1THNSL1 GNAI1 TIAL1THRA SLC25A36 CREB3L1THUMPD1 LMAN1L C16orf91THUMPD3-AS1IL36A TBC1D25THYN1 HRASLS2 KIAA1549TIAL1 GPA33 DNAJC2TIMM10B TLK1 CFAP36TIMP2 LPXN ZER1TLL2 NUP153 PSMG3TM4SF18 DDX21 TMEM167ATM7SF3 MRPL18 ZNF362TMED1 FRS3 HSPA13TMEM106CARHGAP15 /// LOC101928361CCP110

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TMEM132ASLC6A20 LDB1TMEM133 TXNL4A MTO1TMEM143 KCNB2 PIH1D1TMEM145 ALDH1A1 BRSK1TMEM14A ARID5A STAT6TMEM150AGCA MR1TMEM150CCSTF3 FHOD3TMEM165 IGLC1 CBX6TMEM169 ITFG1 SART3TMEM192 SNCAIP WDR46TMEM223 MAP2K7 MNX1TMEM230 STRAP FNBP4TMEM234 FZD2 NFX1TMEM25 AP3B1 MMUTTMEM253 CD38 NUP214TMEM260 TAOK1 ZCCHC4TMEM39B SERPINB10CDC5LTMEM41B RNF6 TRAPPC2BTMEM42 NOC3L ZNF470TMEM43 KIF2A DDX19ATMEM72 UBE3B RNF185TMEM74 MKL1 CNEP1R1TMEM88 SERPINF2 UBE4ATMEM92 PLEKHB2 TRAK2TMEM98 NDEL1 ERG28TMPRSS5 CAPN5 RAMACTMX1 ITGAE DDR1TNF RPF1 MCMBPTNFAIP2 CCL16 CCDC186TNFAIP3 IGHG1 /// LOC100293211SLC4A1APTNFAIP6 GPN3 IARSTNFAIP8 DPYSL4 HBP1TNFSF13B MFAP1 RCN1TNIP1 SCAMP1 EIF4EBP1TNIP2 GOLGA4 ADM2TNIP3 MYCLP1 /// MYCLP1TIGD7TNXA IGK /// IGKCNBEAL2TOLLIP-AS1PRKACB RLIMTOM1L1 ADAM28 GLIPR2TOMM34 CYB5R1 BRI3BPTP53INP2 ACOT1 /// ACOT2PCDH1TP53TG1 RNF167 ZNF10TP53TG5 DDHD2 MMP24OSTPI1 CDC5L ZNF26TPP1 ADAM8 ERCC8TPPP3 CLGN CSNK2BTRAF3 DNAJA2 RACGAP1TRAF3IP2 PSG2 COPG2TRAF5 GMIP TMEM164TRAPPC2 CD2 TMEM106C

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TREM2 MRPS12 PLCXD3TRERF1 DIMT1 YAE1TRIAP1 RTN1 USP8TRIM45 PRKD3 MTMR6TRIM65 FMNL1 PEX13TRIM7 ACRV1 SLC30A9TSEN2 ALOX12 TRIM68TSFM PRKAB1 FBXO42TSN PAK7 EEF1E1TTC17 LYPLA1 ZMYM6TTC19 QTRTD1 EHBP1L1TTC32 TERF1 FAM222A-AS1TTC39B PDSS1 ZRANB1TTLL1 GTF2E2 BRAPTUG1 PYGM ATL2TXNRD1 PTK7 SLC25A51TYRO3 MRPL41 ITCHUBAP1L CYP17A1 IKUBD LTBP2 GCNT4UBE2G2 PRX ADAM17UBE2N AGRP CDK7UBXN8 PHB2 PTGFRNUCN EXO1 GSSUCP2 BBC3 /// MIR3190 /// MIR3191SYT4UGT2A3 USP5 USP16UGT2B15 ZNF391 RAD9AUIMC1 WDR44 MON1BULK2 CUTC TEFULK3 DPM1 LPCAT1UMPS CIB2 OSTCUNC5CL TMEM30B MAFURB2 EXTL1 PSD4USF1 ACYP1 TSPYL2USP28 OSBP PURBUSP38 SLC25A38 ZNF829USP43 ADORA1 C1orf109UTP20 FUCA1 AMPD2VASH2 EEF2 CLPBVAT1 TNK2 VAMP4VAV1 PRKAR1A ZNF841VCL TMEM208 DDX49VCP SPIB HMGB3VDR ALX4 SLC52A2VIM CNGB3 MTRRVIPAS39 ABHD11 TMUB1VPS25 GPR157 PAPOLAVPS35 CBWD1 /// CBWD2 /// CBWD3 /// CBWD5 /// CBWD6 /// CBWD7 /// LOC101060578C1orf43VTCN1 KPTN QPCTLVWA5A FAM49B PTBP1WASH5P C1GALT1C1MAFG

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WASL DUSP11 ZNF527WDR25 APOO INSWDR3 EEF1G /// MIR3654UNC5CWDR31 SLC39A6 LRP5WDR37 GPX5 FUBP3WDR6 CPD GSTK1WDR70 SNRPN /// SNURFTXNDC9WDSUB1 HIGD1A ZNF75DWIPF1 TASP1 B2MWLS C6orf120 TKTWNT2B H6PD GDI2WTAP DBT VAV3XKR4 CES1P1 TLE2XPC RCHY1 BNIP3LZBTB16 CDS2 OIP5-AS1ZC2HC1A PRKAA1 TEX30ZC3H12A RBM3 CFC1ZC3H12C FABP7 PSAT1ZCCHC7 PTDSS2 BAMBIZFAND6 DYRK2 LAPTM5ZFP2 CDK7 RAVER1ZFP3 C22orf24 CTSBZFP62 CYP2A7 ZMYND19ZFP90 SNRPB FBXW8ZGLP1 GLRX3 KANK1ZKSCAN1 ADD3-AS1 HMGCLL1ZKSCAN8 ZBP1 RGP1ZMAT1 AKAP9 NIFKZMPSTE24 MXRA7 UBTD1ZMYM3 TMEM209 COLCA1ZNF112 MMP26 GDF11ZNF135 BARX1 ABATZNF174 SKIV2L COL4A1ZNF177 CLINT1 FLT4ZNF202 SYT12 SLC7A1ZNF234 SRP19 USP38ZNF239 PGF FOXRED1ZNF248 CHI3L1 RXRGZNF25 RGR TIMM21ZNF263 GIPC1 CMSS1ZNF285 PTAFR SMARCC2ZNF3 ZNF783 RTCBZNF30 C1D C1orf174ZNF311 GRAP SERF1BZNF32 RANBP6 STRAPZNF345 TWF1 LINC00673ZNF362 CASD1 SORL1ZNF404 GRK5 TIGD5ZNF418 SEC24D UTP6ZNF429 TSSK1B WAC-AS1

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ZNF431 IL1RAPL1 MAGI1ZNF449 GRB10 SATB1ZNF487 IFNA16 ILVBLZNF525 MZT2B NUAK1ZNF527 YEATS4 DKC1ZNF564 MRFAP1L1 FIP1L1ZNF565 BMP7 UBALD1ZNF589 PPP1R14D CDH5ZNF595 PLXNA3 SAFB2ZNF606 TYR SOD1ZNF623 ZNF286A FKBP15ZNF641 SNF8 HOMER1ZNF662 SLC34A1 TNS1ZNF70 DDX3X ASB1ZNF763 CAAP1 EDARADDZNF823 NR1I3 SEC24DZNF835 POLR2J /// POLR2J2 /// POLR2J3 /// UPK3BLURB2ZNF862 IBTK CFAP20ZNF92 TTC33 SETBP1ZNF93 EPB41L3 LINC00294ZNRD1ASP IL1RAPL2 TCP1ZSCAN20 APLNR ARFIP2ZSCAN21 CD70 RING1ZSCAN32 SNRPD3 TAF4BZSWIM8 RTN2 C12orf57AAED1 KDM6B ARIH1AAR2 FZD6 ORC4ABCA3 ENTPD1 USP1ABCC8 KLK13 RUNDC1ABHD10 RIN1 MTDHABHD15 KCNA1 LOC643072ABLIM1 OR10C1 CBWD2ABT1 PRUNE2 CYP2J2AC007204.2ANAPC10 CDC42EP4AC007383.3INF2 PPP1R15BAC019117.2ZMYND11 MFSD9AC079630.2FAF1 IRS2AC090044.1MMADHC PSMD13AC123768.4BDKRB1 SF3A2AC132216.1SF3A2 MTA2ACACA VIM AKAP8ACAN GTF2B RAB33AACE ELANE LNX1ACOT1 KRT5 CD59ACOT2 EIF4G2 WDR90ACRBP PPP2R3C NBR1ACTRT3 EPPIN /// EPPIN-WFDC6POM121ACVR2A PHLPP2 SUPT7LADAM22 CALHM2 MRGPREADAMTS2 CLCN1 SENP3

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ADAP2 DIAPH2 IGFBP4ADCY2 SIN3B HGDADCY5 COG2 DNAJC7ADSSL1 RSRC2 SETD1BAGBL4 LA16c-381G6.1ZNF674AIF1 RPS18 SRSF8AIG1 EDA2R TRMT44AK9 CDC25A SCG2AKAP5 IGHG1 /// IGHMPDHXAKIRIN1 HYAL4 UHRF2AKT3 ATP2A2 ATP9AAL121761.2RCBTB2 KAT2AAL589765.1FZR1 PARNALDH5A1 GPR52 C18orf25ALPPL2 CHRNB2 MAML3ALS2 ZNF574 ZNF12ALS2CR11 TBK1 ST6GAL1AMBP RP3-497J21.1DBIAMER2 SPG21 CCPG1AMER3 HSD17B10 RBM48AMIGO1 YTHDC2 TSNAXAMZ2 GMEB2 AURKAIP1ANKMY2 MAT2B ARMC6ANKRD20A1HIST1H1A UBXN8ANKRD20A2KCNMA1 ZRANB3ANKRD22 ZNF771 CEP120ANKRD39 NCOA4 TMEM132CANKRD7 ASCC1 KREMEN1ANXA6 WDR62 TIMM23ANXA7 PLS1 GOLGA4AP000688.29RNF38 NUP35AP000769.7EVI5 KCTD20APCDD1L AARS LAPTM4AAPH1B ERBB2 RDH13APOB GNB2L1 /// SNORD95 /// SNORD96AINHBEAQP4 ATP6V0B SLC29A1AQP7 SACM1L GCH1AQPEP SSBP1 DDB1AREL1 PRKG1 TMEM50BARF5 DIP2A SMAD4ARHGAP10NPHP4 SDHAF1ARHGAP20FBXW11 CHCHD4ARHGAP36FAM66D ACAA2ARHGEF26 BLK FBRSARHGEF6 PPFIBP1 RFC4ARIH2OS SYNCRIP CELSR2ARL15 UGP2 KLHL15ARL2BP SCAMP3 PNMA1ARL3 OXSR1 CYLDARNT2 MICALL2 ZNF44

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ARSI AP1AR CNSTARV1 GOLGA7 GLTPASAH1 PPIB DNAJB12ASB8 ZNF611 EPAS1ASH1L-AS1 UFL1 MAP1LC3B2ASL ANXA2 /// NHP2L1AP3M2ASNSD1 ATP2B2 ATP5MC3ASTE1 WRB PXDNATG9B HINT1 EIF2B2ATP1A3 BCAS1 MMP24ATP2A3 CHD3 ZNF274ATP6AP2 ART4 LRFN2ATP6V0B EIF3A VIRMAATP6V0C COPS3 NLRC5ATP6V0D1 DMC1 GBAATP6V1D TNNI1 STRIP2ATP6V1E1 C9orf3 PUS7LATP6V1F CNOT2 PTPRFATP6V1G1 TMEM33 TADA1ATP8A1 YIF1A CCDC146ATPAF1 SIRPB1 ZNF548ATXN1 CSTF1 GLRA1AVPR1B CAPZA2 CYB561D1B3GALT4 KCNJ1 FZD1BACE1 DRD1 ASCC3BAG5 ACTN2 BMS1BANK1 PGAP1 CARM1BAZ1A SEC11A HFEBBS4 TP53AIP1 FZD4BCAR3 LOC101060363 /// PPIAFBXO36BCAS2 KIAA0196 CNKSR2BCHE GMPR2 GORABBCL7B KHSRP NPPA-AS1BCL9 MYO9B ELP3BCLAF1 APIP RGS2BEND5 SAR1B AAMPBEST1 TFDP1 ZNF783BEX2 RP11-680F8.4SGCBBEX4 NDUFA5 PDLIM1BEX5 MEX3D PLXDC1BLCAP YIPF6 MTHFD2BLOC1S2 GPSM3 MLF2BMP8A RNF34 CASC4BRAP HTR1A CCDC40BRMS1L SLC38A3 C5orf66BRWD1 LRCH4 /// SAP25PRKCQBTBD3 POLG MOKBTBD6 MYB AAK1BTN3A2 ARHGEF28 BFARBX088651.1BIRC7 ZNF568

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C10orf107 GCG CXorf40BC10orf95 RPLP2P1 /// RPLP2P1BOLA2-SMG1P6C11orf1 CCR8 TMEM119C11orf70 ALS2CL LOC100130283C12orf23 TRIM37 PLEKHM1C12orf76 ARHGAP6 AHSA1C14orf182 IL19 PARP14C14orf28 APOL1 NECTIN3C15ORF37 SMAD4 RBSNC15orf40 COX11 SHQ1C16orf87 CYCS RNF167C17orf100 CNOT7 ZNF566C17orf104 MAST2 DHX40C17orf105SSX2 /// SSX2BZNF398C17orf82 RPL35A SETMARC1D HOXC11 FAM220AC1orf112 ELSPBP1 MCHR1C1orf132 COPE RPF2C1orf233 TBL2 IGFBP5C1orf52 CUL4B MFFC1orf74 RNF122 CLN6C1QB MKS1 TOMM20C1QC BLM CLDN15C1QL1 TMEM248 CRAMP1C20orf112 CTLA4 TP53BP1C21orf119 FOXD2 NSUN4C22orf26 IMP4 TLR5C2orf70 SCG2 NR2F2C3orf14 CACFD1 BMP8AC3orf18 DNAJC12 ABCF3C3orf33 ST8SIA5 CHST2C3orf67 SLC39A14 ZNF230C3orf83 PPP3CB ATP6V1DC5AR1 FGF5 NOP14C5orf55 RHBG RAPGEF3C6orf57 CDR2L PARLC7orf55 OR2H2 SPRED3C7orf73 EIF5 CDC40C8A PTPN11 SH3BGRLC8orf4 ZNF468 ANKRD40C9orf72 LAT2 SUSD1C9orf91 SLTM ORMDL1CACNA1B LIPA FCF1CACNG4 SMAP1 PIP5K1ACALB1 GRSF1 PLXNA2CALD1 IQSEC2 PLUTCALHM1 MLPH ZNF253CALHM3 ITPK1 USO1CAMK2D TMEM59L CDH24CAPN1 DCC PDXDC1

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CAPN13 APPL2 UBXN1CAPN14 EDF1 CDC73CAPN7 CHPT1 CALCOCO2CARTPT VAMP5 ZNF787CASC19 TRIM13 STN1CASP3 RPA2 PPIL4CASP8 FOXP3 TSTA3CBLN1 PHOX2A ZBTB8BCCDC176 TJAP1 PAK1IP1CCL26 LOC728392ZNF451CCL3L3 LOC101927770LOC93622CCNT2 NUPL2 RSL1D1CCSAP ARMCX2 LIN37CD22 FBLN1 CDHR1CD247 KANSL2 MUL1CD302 PDCD1 FGGYCD36 DNASE1L3 FURINCD48 DGKI FZD3CD97 SLC4A1 PPANCDA ENTPD5 GCHFRCDC14B MTRR CIAO1CDK17 PRR11 MXD1CDKL2 FIS1 ZBTB21CDO1 FZD5 CMIPCENPC GPR20 RSAD1CEP85L STATH ZNF605CERK CCBL2 SMU1CFB SAE1 EIF4A3CFTR HIST1H4I CCT6ACGRRF1 MIR1304 /// SNORA1 /// SNORA18 /// SNORA32 /// SNORA40 /// SNORA8 /// SNORD5 /// TAF1DUBE2J2CHADL CDHR5 UQCC1CHCHD2 ACTR1A CEP192CHD9 GABRB2 DDX39ACHGB LOC100288570HINFPCHRM4 CXorf57 DAPK3CHRNA4 TBX1 PPIP5K2CHST9 BMP1 GPM6ACKMT1B ZCCHC14 SGTBCLEC14A ABCB9 GAS2L1CLIP4 HOXD9 GPR89ACLLU1 OR5I1 ZC3H18CLLU1OS GRM3 ATP2B4CLPS DNM1L FKBP5CLPSL2 TRA2B FZR1CMBL PRPF18 HPRT1CNDP2 ODC1 IBTKCNEP1R1 DNAJC9 CDK20CNGA4 CCNJL LOC101927151CNTFR PITPNA BAG6CNTN4 RNASE2 PODXL

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CNTN5 MEF2A PAF1COPS3 GPR4 RNF168COPS7A XRCC6 SUCLG1COQ10B CLCF1 RMND1CORO2A PSMA3 RECKCP WDR55 CCDC47CPA1 TBL1XR1 TOMM70CPB1 RBM25 MARCHF2CPQ WSB2 PPP4R3BCRABP2 PPA1 SLC25A46CRAMP1L PIK3IP1 LMF2CRISPLD1 TTC9 SUSD4CRY1 STX3 ALMS1CSPG5 CEMP1 LRFN4CTA-221G9.7MFGE8 SBNO1CTB-43E15.3CCR4 YIF1BCTC-332L22.1EVPL MAN1C1CTC-360G5.9SS18 ZBTB18CTC-534A2.2DBH GMPPBCTD-2003C8.2GREM1 PCDHGA12CTD-2037K23.2NDUFA7 C12orf4CTD-2186M15.3CYP11B1 THOC5CTD-2207P18.1MAPK8 TSC22D2CTD-2526A2.2CACNB4 TASOR2CTD-2651B20.1NDOR1 DENND11CTD-3220F14.1PRKCSH SELENBP1CTRC EIF3J IGDCC4CYB5R1 SERPINA7 PCYOX1LCYFIP2 RAB3IL1 UCN3CYP4F12 KCTD9 PEG3CYP4F3 KLHL22 TRAF5CYTH3 LOC79999 MPEG1CYYR1 SLC9A7 TRIP11DACH1 EMR1 WDR81DACH2 EFNA2 MECOMDAGLA B3GNT4 DZIP1DAXX PTPN21 MAP3K7DCDC1 FRY INTS10DCK B3GNT3 RABGGTBDCSTAMP SNX3 DYNC2H1DCTN3 APOOL SNW1DDA1 TP53I11 RAB2ADDX23 RNF14 PON2DEF6 KRT38 DHX16DEGS1 CDC37P1 /// CDC37P1BAIAP2-DTDGCR2 BGLAP /// PMF1 /// PMF1-BGLAPSLBPDHX35 SNRPE CPSF1DIAPH1 EMC10 LINC02197DIO1 GOT2 TTC3DLEU2L PDLIM7 ZNF587B

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DMTN NGFR ABHD18DMWD CD1A TIPRLDMXL1 MOAP1 PRKCZDNAH12 C2CD5 NBASDNAH5 GLRA2 ERHDNAH6 CCDC186 PLD1DNAJB6 PRPF4B C5orf51DNAJC18 AOC1 TIMM17ADNAJC27 MRPL15 NCALDDNTTIP2 AK021933 RBM15DOCK11 PNMA1 NEURL1BDPEP1 TCEAL1 FKBP14DPP6 TMEM183A /// TMEM183BSEMA5ADPPA3 PEG3 SSBP1DRP2 ADORA3 MIA2DSCAM ARF4 AMIGO2DSCR8 TNNT1 SPRDTWD1 RNASEL PROS1DUSP12 SNX7 GTF2H5DYNC2LI1 DGCR6L PLSCR4DZIP3 PLCB2 EMCNE2F6 PLA2G2D NPM1ECSIT NOX5 NR4A2EFCAB2 COX5A ABHD10EFCAB4B FUBP3 ARF1EFS GABARAPL2RARSEGF ANKFY1 KRR1EHD2 FLJ22184 EDC4EID2 PLK3 RWDD1EID2B SMARCA5 FOXJ1EID3 FCER1A TTC26EIF1AD TFAP4 KCNK1EIF3J-AS1 C1orf159 ADGRF5EIF4EBP1 B4GALT5 CSNK1A1EIF5A2 DEFA6 CPSF7EMC4 CEP76 C1RLENPP5 LILRB1 PRRC1EPG5 INPP1 CLCC1EPHA3 MKKS ANKIB1EPM2AIP1 GAD2 NXF1EPO CETN3 RPS6KA1ERMAP CTB-102L5.7TCEA1EXOC8 NDST2 /// ZSWIM8-AS1RHOBTB3EXOSC5 BCL3 /// MIR8085TGM2EXPH5 CBFB SLC6A9EYS MFN2 PAK1F2R FBXO3 LPAR6FAM104A AMH /// MIR4321ZNF324BFAM105A ART1 RCAN3FAM124B BARX2 ZNF324

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FAM127C HLX NUDT22FAM150A GLYAT DUBRFAM159B PACSIN3 ZZEF1FAM162A PMEPA1 MCM7FAM163A GRIN2B SURF6FAM166B CRYZ KHDC4FAM167A PSD3 FBXO16FAM168B NARS2 UBE2D2FAM171A2ATP6AP2 UTP18FAM181B CORO7 ZNF621FAM19A4 BTF3 LSM3FAM200B RP11-403P17.4DNAJC16FAM210B TMEM131 MED29FAM212B HSD17B11 CCNHFAM215A ZC3H7B SPRED2FAM21A ZFC3H1 MON2FAM222A IL3 INTS4FAM229B MDH1 TTC9CFAM46C CTSO PPM1GFAM53B HNRNPF MLLT3FAM66E MEGF9 USB1FAM72B ZNF721 SLC25A42FAM76A EEF1D ARMCX3FAM76B RTEL1 C1orf127FAM8A1 HOXA10-HOXA9 /// HOXA9 /// MIR196BDOCK4FAM90A1 BCL7A NME7FAM92A1 ASXL2 MTRF1LFASTKD3 CSPG4 IKZF5FAXC TLE6 EVLFBXL14 MRPS27 HNRNPUL1FBXL5 KRT33A LYNX1FBXO10 GNE RASSF6FBXO11 PLA2G3 CORO1BFBXO27 C14orf132 DISP3FBXO43 TNFRSF8 VAPBFBXO7 EVC ARCN1FBXW7 MBTPS2 /// YY2UGGT1FCGR1B ELP4 C11orf58FEM1A MRPS11 AZIN2FFAR1 PUS7 SEZ6FGF14-AS2 ERLIN1 CD99L2FGF14-IT1 CDC45 SUFUFHAD1 EBF2 ZBTB43FHOD3 TMBIM6 TPT1-AS1FKBP5 PRODH2 BDH1FLII LGR5 CHCHD3FLT4 AGA SAMM50FMNL2 CMTM6 ADKFOCAD CTSC NBR2FOXO6 PQBP1 ENTPD1

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FOXRED2 FLCN RPS19BP1FRZB EIF3E FANCFFSBP TMEM104 SEC61GFSIP2 ELF5 WHAMMFTH1 DUSP12 ITGA1GABARAPL1EFEMP2 INKA2-AS1GABPB2 HIST1H2AG /// HIST1H2AH /// HIST1H2AI /// HIST1H2AK /// HIST1H2AL /// HIST1H2AMRNF113AGANC NLRP3 RPN1GATA4 FAM118A C14orf93GATS CDC123 LINC01843GBA ZNF451 DENND3GC ALDH1A2 DNAJC1GCH1 NDUFB6 WIPI2GDF11 KLHDC4 SEMA4GGFOD1 CASS4 ATAD2GGA2 SLC6A8 GKGINS2 AC068039.4FAM126BGJA3 KCNS1 SLC17A9GJD2 PYHIN1 PICK1GJD3 ZNF330 TRIM21GLP2R UQCRFS1 MINDY1GLT8D2 TNPO1 SACM1LGNA12 TMEM50B ARL5BGNAI1 RTN3 MATN1GNAI2 DSCR4 JUNDGNAO1 GRAP2 CDK11BGNG10 CD3D DYNLT3GNG5 LEP PHF5AGOLGA6C MTCH2 AP4B1GOLGA8G SIRPA BAIAP3GOLGA8MLOC101927051SIX5GPCPD1 TBC1D9 ATOH8GPM6A DENND1C FKBP9GPR113 SLC13A4 MBOAT4GPR119 CTC-338M12.4SMN1GPR125 RP5-1170D6.1TRNP1GPR142 POT1 FBXW2GPR150 NCKAP1L RPTORGPR157 EPB41 SNX2GPR27 AOC3 TYW1GPR52 TBCE ZFP36L2GPR64 TM4SF5 STAB1GPR75 USB1 SLU7GPR98 ATP6V0A4 ZMYND10GPT2 NCAPH2 PLA2G12AGRB10 B4GALT2 FOSBGRHL2 RBM38 CRIP2GRK4 ARMCX5 NEPROGSE1 MIR3658 /// UCK2NCBP1GTF2A2 IGHA1 /// IGHA2 /// IGHD /// IGHG1 /// IGHG3 /// IGHM /// IGHV4-31ZNF184

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GTF3C4 IGLJ3 /// IGLV3-19 /// IGLV3-19METTL1GYG1 LOC100505498ELK1GYS2 DTWD1 THOC1GZF1 STXBP1 SLC25A25H2AFV ABCD1 CEP350H2AFY CRNKL1 CBWD5HACE1 MYBPC3 SPEF2HBA1 C20orf195 STX4HBA2 PDE3A CANT1HCN4 PER2 TBRG1HDGFRP3 IQCA1 PTPRUHDHD1 PARL NOM1HEPACAM2PTPRN2 CROTHERC3 DRD5 TRAPPC12HEY1 ACAA2 ADIPOR1HHAT HOXB1 UNC119HIGD1B HOMER3 MBD2HIST3H2A DERA TXNDC5HLA-DMB EIF3D CD14HLA-DRA GRIA1 TNS2HLA-G SRCAP SRRHLF FASTKD3 MX1HOPX SKIL CHST9HOXA1 RAB6B TSPAN14HOXB2 DBF4B EIF2B1HOXB3 SCGB2A1 ECHDC3HOXD3 LILRB3 FKBPLHPCAL1 SRRM1 DNMT3AHPD CASP4 RNF5HPDL ADH7 IL10RBHPSE RCN2 TGFBR3HRH4 CCL22 HEXBHRNR PLA2G2F SLC25A53HS6ST1 RPL15 PBXIP1HSCB GFAP CACUL1HSF2 SLC35E3 RANGAP1HSF5 HPCA INPP5FHSPA14 PDCD6IP TMEM11HSPB11 SNRNP27 METTL16IDI2 SAMHD1 CCDC88CIER3IP1 C11orf73 GCN1IFITM2 VCY /// VCY1BEARS2IGFBPL1 GDPD3 ZBTB5IGFL3 NFE2L2 ATG5IGSF1 RRN3 MMP15IGSF21 REST TSHZ2IGSF9 LINC01314 ROGDIIKZF5 ZFR2 TRIM39IL10RB AFF2 JADE1IL32 MB NDN

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IL6R CSNK1G3 ST3GAL2ILF3-AS1 PBOV1 GNG10INCA1 TRAPPC13 ST3GAL5INF2 IKBKE VKORC1L1ING2 TRAIP CAMSAP1INSM1 ETNK1 CEP83IP6K1 CD79B MYO9AIPPK SLIT2 SPATS2LIQSEC1 APOC2 /// APOC4 /// APOC4-APOC2DXOISCA1 CARKD TXNL1ITFG1 HBS1L ZNF850ITGA1 SMG5 PWWP2BITGAM WIZ SESN2JADE1 PTPRD LRRC4JPH4 MYOD1 KDM2BKANSL1L REV3L TXLNGKBTBD11 SSTR5 HEYLKBTBD3 ERP44 C7orf26KBTBD4 MAGEH1 TRIM35KCNA5 MKL2 PDE4BKCNC2 PAAF1 SLC1A4KCNG3 DMP1 CSNK2A1KCNMB4 CDC73 ISY1-RAB43KCNT2 SNTB1 CHPFKCTD14 SCCPDH RASA4BKCTD5 GLOD4 TNPO3KCTD6 SEPT11 SMARCA4KDELC2 HMBOX1 OCIAD1KIAA0895 DCUN1D4 C8orf33KIAA1109 SPCS2 HYKKKIAA1257 CYP4A11 TERF2KIAA1324 OR1E1 /// OR1E2ACBD7KIAA1328 TNFSF12 /// TNFSF12-TNFSF13ALG14KIAA1456 LRRN2 FAF1KIAA1551 RNF185-AS1TRIB1KIF3C TOR1B SLC37A4KLHDC8A USP34 RSPH3KLHL15 ACLY DOK3KLHL40 NPFFR1 PDIA6KLHL41 WWP1 RBBP5KLHL42 KISS1 FEM1AKLK1 VRTN HEATR5AKNDC1 ORC5 SLC25A30KPNA5 NRG2 ATP1B1KRBOX4 ZNF160 SOX13KRT10 SASH3 DNPH1KRT15 TAF1C TRPM4KSR2 SLC19A3 ARL6IP5L1CAM TNS4 CDK4LAMP1 DCAF4 C16orf71

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LAMP3 OSBPL7 MAP3K10LAMP5 ADRA2B ZNF432LAMTOR1 GLUD1 FGD5LARP7 FZD8 /// MIR4683AVL9LDB2 MYOG ANK3LDLRAD3 ASNS MVKLEPREL4 ARG2 ATXN3LGALS3 CYHR1 LIMA1LGALS7B DBET /// DUX4 /// DUX4L1 /// DUX4L2 /// DUX4L24 /// DUX4L3 /// DUX4L4 /// DUX4L5 /// DUX4L6 /// DUX4L7 /// DUX4L8 /// LOC100288289 /// LOC100291626 /// LOC652301MOCS1LHX6 RPS6KB2 METTL24LIMS2 NAT2 TBPLINC00229 GGNBP2 BLOC1S3LINC00271 SPAM1 ABCE1LINC00312 ENG MYORGLINC00441 DPF2 PWP1LINC00461C22orf29 /// GNB1LPPP1R13BLINC00511 NCR2 TPRA1LINC00526 EPS8L3 LURAP1LLINC00574DKC1 /// MIR664B /// SNORA56ZNF710LINC00632 CHST5 STK11LINC00643 KCNN1 DVL3LINC00663 LRRC40 USP10LINC00665 TSPYL5 RASGRF2LINC00683 INPP5D SRCLINC00694 PLXDC1 EML2LINC00870 TBC1D2 SNU13LINC00877 TH HAPLN3LINC00910 REEP5 DDCLINC00925 XPO1 SCAMP3LINC00948 S1PR2 CYB561LINC00960 HBE1 SF3A1LINC00963 F12 NFICLINC01018CDK3 /// TEN1-CDK3ATP1A1LINC01071 GOT1 NCMAPLINC01108 FCGR2C MDM4LINC01116 HDAC7 OPRD1LINC01138 ATP6V0A2 EEF1AKMT3LINC01139 A4GALT ARHGEF28LINC01155 EGR4 TRIB3LINGO2 NOP10 PPARALMO2 BTN2A1 HTRA1LOH12CR2 PLEC EIF3MLPPR4 NEU3 GID4LRG1 RAPGEFL1 RAB1ALRP3 SMC4 ARPC5LLRRC37A ZFP36L2 MAPK7LRRC37A2 IDUA FASTKD5LRRC37B RNF5 /// RNF5P1DMWDLRRC42 EBLN2 SDSLRRC4C SNAPC4 RGS4

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LRRTM4 PLD1 CD93LRTOMT LRRC8B DOHHLSP1 IL13RA2 SEMA6BLUZP2 INPP5F ITGB5LY6H INS STAG1LYPD3 RHOD MYDGFMAFA ABCG5 CHMP7MAFB ZNF614 DNTTIP2MAGED1 HAND2 COL15A1MAGED2 FAT1 AMOTMAGEF1 DCLRE1C OLIG1MAGEH1 MIR21 /// VMP1DHFR2MAN2B2 DRICH1 STAT5AMANBAL MRS2 PIEZO2MAP1LC3CZNF460 GHITMMAP3K15 TMCO3 FXYD6MAP3K5 TTTY2 /// TTTY2BNLGN2MAP7D1 CNGA1 TOGARAM1MAP7D2 ANO2 EIF2S2MAPK1IP1LSESN1 LIMK2MAPKAPK5AMPD1 LGMNMARCH8 TNIP1 ALYREFMB21D1 HLA-DOB MFSD1MB21D2 MAPK1 ZNF226MBD4 ADRB1 SPCS2MBIP TRIM15 RAB29MBOAT2 MISP RNF43MCOLN1 ATP5A1 ABCC9MEAF6 RENBP LMAN1MED27 DYNLT3 VPS4BMED4 BRAF /// KIAA1549ISL1MEX3B MFNG LINC01614MFSD2A NBN DDX47MFSD4 ANXA2P1 SUDS3MGAT4C DNAH17 LOC100996740MICA LINC00597 OAS1MIR4458HGYIPF2 ABCC1MKRN3 LOC647070GIHCGMMP28 DBF4 GTF2H1MNS1 ARL3 UBN2MOAP1 RABGGTA PMPCAMOB1B C19orf40 EAPPMOGAT1 KRTAP5-9 ATP5F1EMORF4L1 SLC20A1 LINC01534MORN2 PMS2 /// PMS2CLNCS1MPC1 EIF2B2 ROBO4MPC2 ZP2 RAB11FIP5MPPED2 ZNF576 PPP6R1MR1 NAP1L3 HIPK1MRAP2 DSE DDI2

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MRPS6 JAK3 RB1MTERFD2 CDKN2AIP ARMH4MTFP1 MAGED2 ATG4BMTHFD2L CHRNG RTN4MTPAP FBXO40 TMEM38AMTURN CALCR RSBN1MUC12 INHA RPS6KB2MVB12B ATG3 ARL5AMXRA7 CD74 DZIP1LMYBL1 PRKAR2A FAM114A1MYBPHL RAI1 TMEM97MYEF2 ARF3 ZNF667-AS1MYH4 XPC ZNF454MYLIP MGAT2 MAEAMYO1D EIF3I REXO1MYSM1 EFNB1 EIF3JMYT1L DRD2 FOXA2NAA20 TAF1D HOPXNAAA GHITM CDC6NABP1 CD300A NIPAL2NAF1 LIN7C VPS54NALCN AKR1B1 RIMS1NANOS1 MIR6125 /// USP15POLRMTNANP OCRL TXNL4ANAPB LIME1 AKIP1NBPF24 SCG3 ENTPD7NCAM1 HP LPPNCAPD3 RSBN1 ISLRNDFIP1 SHQ1 RAB22ANDNL2 ECHDC3 CMPK1NDUFA5 EHMT1 AHCTF1NEGR1 CNN2 TIMM9NEIL2 SH3GLB1 INF2NEURL1 PMPCA PDE6DNEUROD1 SLC39A7 ZFP41NGFR HLA-DRB4 DTX3LNHEJ1 FLJ11292 LTBP3NHLRC4 NCK1 LZTS1NIPSNAP3BMLC1 FBXO5NKAP APOBEC3GTMEM259NKX6-3 DEF8 ZNF830NLRP6 RP11-457I16.2KLHL35NOL9 SDHC NFATC4NOX4 GOLPH3 TPPPNPTX2 CPED1 TMEM109NPTXR LOC100130741KCNK16NR5A2 QRICH1 LIN54NREP NDUFA1 PRDM4NRG1 CLASRP PLXNB1NRG4 PTGIS GLB1

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NRK PPCS RTF2NRL HHAT RFLNBNRSN1 NUDT15 RUVBL2NRXN1 PNPLA3 NOTCH4NSG1 FOXO4 BLOC1S6NTN3 TACR1 ZFP64NTNG2 CDKL2 PSMD9NUAK1 ETV4 SFXN1NUCKS1 SCNN1B CNIH1NUDT11 RPIA PPLNUDT16 KDM5C CSRNP1NUDT19 GPS2 IRF9NUFIP1 NHLH1 DESI2NWD1 FCRL2 STX6NYNRIN FPGS CALUOAT CSAG2 /// CSAG3RNF4OAZ2 MSL1 NDUFC2OCIAD1 RP11-714L20.1PCDHB13OCRL PRPF4 METTL2BOLFML2A ATRAID RNASE1OLIG1 CUX2 DNMT1OXA1L SOCS5 REREOXGR1 HCRTR2 MBNL3PACSIN2 FRMD8 DYNLL1PAPPA2 PRO1596 LDLRAD3PARD6G PLA2G5 WDR61PARVB TEX40 EMG1PCDHA7 PRPF8 DTNAPCDHB16 TXNDC9 ARFGEF2PCDHB5 DHX30 GSTO1PCDHB6 CUEDC1 PCSK9PCDHGA9 ZNF302 GPR173PCDHGB2 ALAS1 RIT1PCDHGC4 EFNB3 PIGHPCED1B MUC16 MRPL46PCMTD2 SEC22B DSTYKPCYOX1L FOXD4 /// FOXD4L1LOC100287036PDE4D RRP7A /// RRP7BSLC10A3PDE6D TAL1 PDLIM5PDLIM2 GNL1 TMSB15BPDZD2 POLR2A COL27A1PDZRN3 SMN1 /// SMN2B3GALT4PELI3 MARK4 SCNM1PFDN1 C2 CAPN1PFKFB2 C3orf14 PHF12PFKM DDN MYD88PFN2 CDKN1B SARSPGBD3 UTP18 MEF2CPGRMC1 KIAA0907 SEC31APGS1 TRIM25 LRRTM3

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PHF7 RHOH FBP1PHLDA2 RCOR1 PHF21API4K2A KIR2DL5A SLC35B3PIANP PDCD11 SALL4PIGF SBNO1 TBC1D8PIGK LIPC NUDT7PIGP CD19 OSBPL9PIGX PROZ LYRM4PIP5K1A TRMT112 TRA2BPLA2G12B FAM182A /// FAM182B /// FAM27B /// FAM27CARFGAP3PLAGL2 ICA1 CACNB3PLEKHA6 STAG3 PARVBPLEKHS1 VWA9 NEK11PLN MAST1 TENT5BPLXDC2 SNX17 SREBF1PNLIPRP3 SCN5A XAB2POLD4 LY9 SLC6A16POLR2C ESR2 COL1A1POLR2K MRPS35 MTF1POLR3F PEMT TNK2-AS1POMZP3 MAP4K5 TRIM14POU6F2 SLC39A2 TIMELESSPPARGC1B IL18BP RGNPPFIBP2 SMC6 LTO1PPIG RPL8 MRAP2PPM1D MRPL35 RNF130PPP1R13L VNN3 DECR2PPP1R14C RRP15 SLC4A11PPP1R21 ADAMTS2 C9orf152PPP1R8 POLR2C EDF1PPY CDK6 PIGAPRCP TRPV4 VPS26CPRKAR2B GCM1 PNPT1PRKCD NDUFA8 MRPS2PRKRA HSF4 CCDC85BPRLHR LAPTM4A CREBRFPRMT5 PRMT3 SOX18PROC ABI1 CEBPGPROS1 MAP2K1 LRRC27PRTFDC1 VAMP1 VCPKMTPRUNE ABAT MAK16PSAP PCDHGA10PROSER1PSEN2 CGB1 /// LHBADCY3PSIP1 PCDH9 PTPN4PSMB9 GJA4 SEZ6LPSME2 ABHD10 CYB5D2PTCHD3 NIPA2 EEF2PTPLAD1 FBXO28 KIAA1549LPTPN1 SFTPB TMEM132APTPN18 PIK3CA ZKSCAN5

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PTPRN2 RPL36AL MYO19PTPRS CHRNA4 GCATPUS10 PIGC KIAA1211PWRN3 CER1 OXGR1PYGO1 ADCY3 SEMA4FPYURF APOLD1 /// DDX47KIF16BQDPR IMMT ZNF410QPCT NR2E1 TPPP3RAB12 SYT13 CETN2RAB1A TSC22D4 DCAF16RAB3C INTS8 USP13RAB3D ROBO1 RNF121RAB7L1 MYOZ1 ST6GALNAC6RABL5 CAV3 FAM185BPRAC3 CALML5 HMGB2RAD54L MYCT1 TADA2BRAE1 GSDMD GRAPRALGPS1 MORF4L2 KCNK3RAP1GAP2 ACVR1 FAM20CRASGEF1B OSBPL11 PCID2RASGRF1 CEP350 DDB2RASSF5 CLIC5 G6PC2RAVER2 SDK2 CBX8RBM48 BLMH TENT5CRBP4 EIF2AK3 SLC8A1RCAN3 AKTIP P2RY8RECK FES NAXERET EDA GRIN2ARFPL1 ZNF710 TMEM161BRFXAP DCAF6 DOCK10RGPD3 ROCK2 RTN4RL1RGPD4 CACNA1E CKS2RGPD8 CA7 RFX5RGS2 POU3F3 NUP98RGS9 CLDN11 CMTM7RHBDD2 SPO11 TMEM53RHBDL3 GLRA1 PRRC2BRHOBTB3 SSR4 TOMM6RHOQ HDAC11 MRPL38RIMBP2 C1orf27 NRBP2RIPK1 SHOX2 CTNNAL1RMDN2 H2AFV EDN3RNF152 AXL RBAKRNF181 ATP6AP1 CARMIL1RNF4 TSPAN32 KDM4CROPN1 COX7A2L POLA2RORB RAD54L2 RBP1RP11-1000B6.3KCTD7 /// RABGEF1ZNF790-AS1RP11-1000B6.5FOSL2 TBL1XR1RP11-100G15.10GINS4 FGG

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RP11-101E14.2ARMCX4 RAB3GAP2RP11-1094M14.11SPTAN1 B4GALT7RP11-109D9.4RNF5 HIRARP11-111K18.2GUCY1B3 CTHRP11-1151B14.2ACTR10 SMIM30RP11-122K13.14TMEM47 PLBD1RP11-129M6.1PAOX DNHD1RP11-131K5.1BTN1A1 PMPCBRP11-158H5.7SLAMF8 CIAO2BRP11-180P8.3RAB21 ZNF740RP11-182L21.6YY1AP1 MINAR1RP11-209K10.2CIAPIN1 DCAF7RP11-222K16.2KRT1 DAPK1RP11-22L13.1ADCY8 RXRBRP11-247L20.4MYO5C POGKRP11-268G13.1RAB22A DGUOK-AS1RP11-271M24.2AQR EIF1BRP11-290F20.3RPA1 MAMDC2RP11-293M10.5DNAJB6 /// TMEM135SNUPNRP11-2B6.3CRYM ERGIC2RP11-2E17.1PPIL6 KCNE3RP11-30K9.6RPL3L WRAP73RP11-317P15.5HAP1 COL3A1RP11-31F15.2FCGBP SEPTIN11RP11-326C3.13FBXO21 TESCRP11-345J4.5ICAM4 AK7RP11-347C12.10ANKRD1 AIDARP11-375B1.3PRPH CCDC66RP11-381O7.3PPWD1 PDK1RP11-38P22.2MAPK8IP2 CRTC2RP11-419C23.1TCERG1 UNC50RP11-423O2.5SDF2L1 SLC39A9RP11-42O15.3HCG18 PRXL2BRP11-433J8.1PIK3C2A SLC25A26RP11-466C23.4LPAR1 UNGRP11-472N13.2ALPP LYRM9RP11-480D4.6TNFRSF25 PPP1R3BRP11-480I12.7MLH3 ECM1RP11-48G14.2ERF PRPSAP2RP11-496B10.3SPHK2 MRPL17RP11-498E2.7ECE1 PIK3C3RP11-502I4.3HERC2P3 /// LOC101930458TSTD3RP11-51J9.5FEM1C MYH10RP11-521O16.2ZSCAN18 CWC22RP11-532F6.4NUDT3 TTNRP11-533E19.5PURA VGFRP11-543C4.1SIRT2 UCHL3RP11-557C18.4SUZ12 FRG1RP11-563J2.2ICAM5 SLC35C1RP11-572M11.3DENND5A MEF2D

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RP11-573G6.10VPREB3 GDNFRP11-61J19.4TTC17 SCCPDHRP11-622K12.1LPAL2 MAP4K5RP11-626H12.2KIDINS220 PDGFRBRP11-626K17.3AR COL18A1RP11-637A17.2DOCK6 SLC41A2RP11-646I6.5NUP107 LAMTOR4RP11-689K5.3SLIT3 ST18RP11-6N17.4SCARB1 SLC27A3RP11-77P16.4PGM3 SUGT1RP11-79O8.1LARS2 SLC9A3R2RP11-79P5.9KCNG1 CA13RP11-7F18.2TROAP GLIS2RP11-7K24.3NLRP1 PASKRP11-822E23.8IFT122 LRRC10BRP11-831A10.1CSF2 KIAA0319RP11-855O10.2FAR2 WDTC1RP11-85G18.6PNRC2 EVA1ARP11-91G21.1SULT1B1 TMEM54RP11-91J19.4HBP1 KDM2ARP11-923I11.6SYTL2 ZNF16RP11-92K15.3SH3BGRL C4orf19RP11-97O12.2TDG PPFIA1RP13-539J13.1RAC2 WDR18RP13-631K18.3NKX2-5 TKFCRP3-393E18.2CLTC GSTM3RP3-400B16.1ROR2 NTPCRRP3-430N8.11COX6C PPP1R3CRP4-535B20.4FURIN COL6A3RP4-594I10.3PVRL3 SOX6RP4-666F24.3DNAJC6 ATXN7L1RP4-765H13.1POU3F4 CFAP61RP5-1004I9.1ASAP1-IT1 IAPPRP5-1021I20.2SNX10 AP3S2RP5-933K21.3CDH15 EEF1AKMT2RP6-206I17.3IGSF9B DPH1RPAIN KIF17 TSPAN17RPH3AL SV2C TFIP11RPL10A IL17B FAM102ARPL11 ARMC1 PKD1P3-NPIPA1RPL12 GPX3 CXXC4RPL13 CTSB SLC11A2RPL18A ASCC3 PPP2CARPL23A POP4 PHETA1RPL32 MDFI ZNF646RPL35 PDE10A NAB1RPL35A UFSP2 CARD11RPL36 QPCT INTS1RPL37A SON CTDNEP1RPL4 APTX UBE2Z

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RPL7 CNN3P1 /// CNN3P1PSMD7RPS12 TSPY13P /// TSPY13PZNF853RPS19 TRPM6 TMEM214RPS2 PRSS22 SLC2A6RPS24 RGS4 ANKRD39RPS29 CDK5RAP2 TSPAN3RPS5 MATK GSK3ARRAGB B3GAT1 SLC40A1RRAGD MRM1 WSCD2RRN3 STAT2 RIC8ARSPH10B ERVH-6 PWWP3ARTN2 THUMPD2 GGCXRTP4 CDC7 RASL12RUNDC3B PRLH SMIM15RUNX2 SNORA29 /// TCP1B3GNT2S100A14 SEPT9 SFXN4SAAL1 SORBS3 TP53INP2SALL2 LOC102724985 /// PDXDC1KCNA3SAMD3 TNFSF8 RALGAPBSAMD9L ATP6V1H WDR48SAMM50 PHTF2 GANABSBK2 AC002310.7 /// ZNF785KIFC3SCAMP5 BRINP1 PCDHB5SCARB2 FAM182B /// FAM27B /// FAM27CAPOL4SCG3 DEK MPNDSCGB2B2 ITIH2 SCARB2SCGB3A1 PCF11 AKAP9SCGN MGC40069 /// TRAC /// TRAJ17 /// TRAV20 /// TRDV2 /// YME1L1SMIM19SCIN RECQL5 PUS3SCP2 ALDH18A1 PRR14SCPEP1 PEPD BCL6SDE2 ERBB2IP SPICE1SDPR CD7 ANKRD6SEC14L5 RPS12 C11orf98SEMA3G NIT1 ZC3H4SEPT1 HIST1H3I EXOSC5SEPT11 EPB41L5 SIDT1SEPT3 ITGA7 URI1SEPT6 ATP5G2 PPP1R16ASEPT8 PDX1 PLK3SERF1A NARS IL13RA1SERF1B TOMM70AMAFFSERP1 SOX4 POLR3FSERPINI1 AKAP2 /// PALM2-AKAP2ERN1SERPINI2 BBOX1 GOLGA6L9SESN1 PCCB DNAJC27SETD2 TAOK2 GMCL1SGCE TIMM23 /// TIMM23BNAPASH3BGRL NAE1 GRWD1SH3GL2 RIMS1 TRIM11

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SH3KBP1 CAMK1D LINC01138SIGLEC10 HAPLN2 SLC29A4SIMC1 SH2D4A PRSS12SIX5 EGFL7 NME4SLBP STX18 LRRN1SLC13A5 RAB30 SEC14L6SLC16A9 TGFB3 ZNF510SLC18A3 TRA /// TRAV16 /// TRAV16 /// YME1L1GSTM4SLC1A5 RAD51C TSPAN2SLC22A15 GRTP1 PRG4SLC22A16 TICAM1 RFX6SLC25A36 KIAA0509 TERF2IPSLC25A38 PRDM4 IMPA2SLC25A47 FHL1 FLNBSLC25A53 WISP3 FCER1GSLC29A1 CDC23 METTL4SLC30A4 TAF7 SHISAL1SLC30A8 GSAP ACTL6ASLC35E4 RAD23B MYNNSLC38A4 ALDH3B1 NCK1SLC38A5 SCRIB SSU72SLC43A2 PPAN /// PPAN-P2RY11DCTN5SLC44A5 PTPRC TMEM184CSLC46A3 FXYD7 GOLGA2P10SLC4A8 TP73 B4GALNT1SLC5A12 SEPHS1 ELAVL4SLC9A9 PNPLA6 LOC105376805SLCO1A2 NR2C1 ANKZF1SLITRK1 UBE3C LRRC41SMARCA1 PRORY VPS35SMARCC2 CCT3 /// LOC101927137SEC24CSMIM4 MYOZ3 MKKSSMIM6 TMPRSS4 MAP9SMN1 PZP ASXL3SMOC1 SENP6 SLC9A7SNAP91 ARHGEF38 RAB33BSNIP1 NDST4 RNF213SNRNP27 PKD1P1 ZNF212SNRNP48 ADAM22 EDEM1SNX12 RB1CC1 F5SNX29 MAPK11 MFN2SOCS2 FCN2 LZTS2SORBS1 TNK1 CFLARSOX9 NCDN FAM222BSPAG16 ADNP2 TSFMSPAG5 COL9A2 CTSCSPARC OVOL3 BRF2SPATA18 SPATS2L C17orf97SPATA7 SSX2 /// SSX2B /// SSX3LRRC49SPATS2 UPK1A ZNF24

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SPCS1 DUOX1 PCDHB14SPOCK2 LINC00599 /// MIR124-1FMO5SRGAP3 BMI1 /// COMMD3-BMI1B4GALT3SSTR2 SMR3A C2CD4BSTAR MRPL28 MCEESTMN2 UBE2N PBX1STOM AVPR1B SMARCA5STON2 ITGB1BP1 ZNF84SUMO3 SEMA6A PDK4SVIL TM2D1 LOC107985246SVIP PLEKHG6 TOB1SYNDIG1L RNF4 CHMP4CSYT11 BRD7 C4orf47SYT15 CABP1 IMPDH1SYT6 THNSL2 ARID3BSYT7 KCNMB3 MVB12BSZRD1 UHRF1BP1LPPM1KTADA1 C1orf95 SPDYE18TAF5L FOXB1 AKNATAGLN2 DUSP21 MATN2TAPT1 ZCCHC10 CD200TATDN3 EBAG9 TMEM125TBC1D20 GPR144 ZNF321PTBCC CBX1 SCN9ATBPL1 FAIM3 TMEM70TBX1 DENND1B FOXN3TCEA1 SERPINC1 CDC34TCEAL1 HSPE1-MOB4 /// MOB4ZKSCAN8TCEAL4 RP11-217B7.2GRB14TCEAL7 INSM1 MAGOHBTCEAL8 PNPLA2 MORC4TCEANC KCNN3 STAM2TCEB1 TUSC3 USP42TCERG1L NTNG1 HMGB1TCF24 IFITM1 ANKRD34ATCTEX1D2 HMGB2 ZNF7TEC NAA50 PPT1TGFBRAP1 HSF2 USPL1THBS1 CHD1 GET3THG1L JRK RAE1THOC5 NEK4 LBHD1TIGD6 TUBA8 GAPDHTIGD7 GRAMD3 SAC3D1TIMP2 SLC10A1 BLVRATINAGL1 SULT1A2 BICD1TINCR ACTR6 SMC5TIPIN ST8SIA2 PFDN2TM6SF1 ARID5B ATXN2LTMC6 IARS2 IFITM1TMEM100 ACAN SNX10

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TMEM109 SEC14L1 DNAAF2TMEM128 CHIT1 PPIATMEM130 CXCL13 GTPBP4TMEM170BCCDC30 ACETMEM184BSCNN1D ELOATMEM185ANUP54 C1QCTMEM189 HP1BP3 ZRANB2TMEM208 TMEM63A DDX55TMEM230 HIST1H4A ZNF343TMEM231 AOC2 MAPK3TMEM232 FAIM RAB24TMEM242 HSD11B2 ME3TMEM251 PHACTR2 BLOC1S1TMEM255AKCNE2 LDHATMEM52 COMMD8 TMED9TMEM55A FCN1 SPATA3-AS1TMEM59 MIR6716 /// PHLDB1LAMA4TMEM66 SPATA31A1 /// SPATA31A3 /// SPATA31A5 /// SPATA31A6 /// SPATA31A7PTPN23TMEM92 OR1D5 EIF3HTMEM9B DISC1 SIGMAR1TMX4 OR10H2 MCRIP1TNFSF4 ESPL1 PDSS2TNNC1 ONECUT2 ENTPD4TOP2B DEFA4 RASL10BTOX3 KCNJ12 /// KCNJ18 /// LOC100996843TSSK3TP53 FAM20B NAGATP53INP2 PAPSS2 TOP2ATPH2 DHX16 IPO13TPPP3 DAP3 PARP8TPR MUC7 FLJ37453TPRG1L TRBV5-2 /// TRBV5-2UBP1TPST1 CFH HSPD1TRAK1 ARID4A YIPF6TRAM1L1 ANAPC2 NAT14TRAM2-AS1SFXN3 CPNE4TRAPPC10 HSD17B12 NEUROD1TRIB2 TACR2 TEKTRIM71 RARS PACSIN3TRIQK SYMPK CISD2TRMT61B LRRC15 GSTA4TSGA10 PAPOLA MFAP3TSHR ANXA7 PTPRETSPAN2 ASS1 ARHGAP30TSPYL1 IGH /// IGHA1 /// IGHA2 /// IGHD /// IGHG1 /// IGHG2 /// IGHG3 /// IGHM /// IGHV4-31SLC3A2TSPYL6 SLC26A1 RHOBTB2TTC19 PCSK6 PGAP3TTC21B CHP1 NDUFAF2TTC23 DLG1 SEPTIN7P2TTC34 RTCA MFSD8TTC39C LSR DIP2C

Page 259 of 781 Diabetes

TTC7B LINC00474 OAS3TTLL9 FRMD1 MRPL18TUBB1 PRSS53 TUBA3FPTUBB8 ADCY6 PIK3C2BTUSC3 MAP3K3 TBCKU2SURP C6orf47 TMEM51UBAC2-AS1GJD2 CC2D2AUBE2E2 MYO16 DENND2AUBE2G1 USP2 KCNK6UBE2Q2 CCL21 AHI1UBTD1 GDF3 CPEB3UBXN10 FAM47E /// FAM47E-STBD1 /// STBD1CCDC69UNC13D NEK3 HECW2USP27X-AS1KCNJ3 JTBUSP39 SMG6 INSIG2USP49 ARF1 /// MIR3620IFIT3USP54 SNRK MOB3AVAMP4 ARFIP1 KIZVMA21 SLC25A46 CACHD1VOPP1 ANKRD53 BTBD2VSIG4 OTOF ZNF264VWA8 PPP2R1B BAZ2AWBP11 APOL5 BCLAF1WBP5 THAP3 ATG16L1WDFY2 BAI1 AMZ2WDR20 FABP5 TMC3-AS1WDR37 AMBN DNAJB4WRB DHX40 OSER1-DTWWOX POLD4 SF3B6XPA TRIM44 SMCR8XXbac-BPG55C20.7HTT PDPK1YRDC LOC100506571TRAM1YTHDF1 CD8A NMT1ZADH2 NOC4L ANO10ZBTB1 SLC28A1 USP15ZBTB2 PTPRCAP CDK16ZBTB26 KRT10 NME6ZC3H12B ACBD4 PMS2CLZC3H14 LOC102725072 /// LOC102725315 /// LOC727983 /// POM121L10P /// POM121L1P /// POM121L4P /// POM121L8P /// POM121L9PDDX1ZC3H7A ACBD3 UBXN7ZC4H2 CD2BP2 EIF2B4ZCCHC18 CAPZA1 MEPCEZCCHC6 KLRC4-KLRK1 /// KLRK1ITPK1ZDHHC24 SUPT16H UPF3BZER1 APOBR ITGB7ZFP37 EXOC2 PCDHGA6ZIK1 UBE2E1 ARHGAP10ZKSCAN2 ASNA1 BMPR1AZMIZ1 MXRA8 THOP1ZMYM5 POLM MPP6

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ZNF12 NPPA LTBP2ZNF134 STAP1 SLC25A35ZNF136 NUDT21 ZNF329ZNF14 VPS54 ZDHHC6ZNF140 GOLGA2P7 /// LOC101929479 /// LOC642423 /// LOC727751 /// LOC80154C5orf22ZNF157 TOB2 U2AF1L4ZNF17 KIF25-AS1 ID2ZNF175 ENO3 ZC3H15ZNF180 PLSCR2 ULK1ZNF222 IL7R SYT16ZNF223 SRPK3 NELFCDZNF230 FMR1 ATP13A1ZNF26 MRPS28 RB1CC1ZNF263 KCNA2 DAPL1ZNF280B ATP5F1 POLR3HZNF280C MVB12B TMEM182ZNF280D NEK1 COL13A1ZNF304 SLC1A6 TAF12ZNF329 DUX1 NAGLUZNF362 SGCD NUDT3ZNF382 CHRM2 BORCS6ZNF385D PSORS1C2 QRSL1ZNF398 INA EPHX1ZNF415 PDGFRL IMMP2LZNF417 RABAC1 PHLDB3ZNF419 CLCA1 CTTNBP2ZNF432 SPAG9 FAM91A1ZNF441 PQLC2 PLAAZNF461 AOC4P COBLZNF484 HIST1H3G KIAA1143ZNF487 TRAK2 CAPZBZNF497 SAG GPS2ZNF502 ETFDH ZNF404ZNF510 KLK8 LOC729218ZNF529 CAPN10 PLD2ZNF534 GATAD1 SH3GLB1ZNF543 PSMC4 CHRNEZNF549 CPB2 RIPK1ZNF566 P2RX6 NUP88ZNF585A MOSPD3 GPR89BZNF586 RNF219 GTF3C4ZNF608 TG PELP1ZNF618 UBXN2B PUSL1ZNF620 CHPF PTP4A2ZNF629 SLC35A5 MREGZNF639 PROP1 TNRZNF655 PPP4R1 MYO10ZNF660 RPH3A UBE2E3ZNF665 ETV7 MIIPZNF667 NAA60 C1orf115

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ZNF709 KIAA1045 TLE5ZNF710 TEFM ATP6V0E2ZNF711 GNAT3 DHRS7ZNF726 ZC3H14 SIX3ZNF740 FOXC1 TGFB1ZNF764 CSDC2 OLFML1ZNF773 MAPK9 PRDM1ZNF774 ATAT1 TLE1ZNF776 SETX CHST8ZNF777 KIR2DL3 CYB5AZNF8 GSTM3 SLC25A36ZNF812 MR1 RAB21ZNF846 DAB1 PLEKHB2ZNF853 IQCB1 CDYL2ZP3 APMAP EIF2AK1ZRANB1 PDS5A FAM161BZSCAN25 DDX41 XIAPZUFSP STX16 MUC13A4GALT ATXN2L AKAP7AAAS THSD4 YPEL5AACS AIM2 NKAIN1AADAC ATP6V1E1 RHOJAADAT IGHD LSSAAED1 ADO SUOXAARSD1 ZNF280B MRPS10ABCB11 CLCC1 YOD1ABCC1 ZNF428 RAD23AABCC3 PEX5 DFFBABCC4 TEX30 SIPA1L3ABCC5 ZFAND6 GPRIN1ABCC8 PRAME SLC35A3ABCD3 HAUS3 NRP1ABHD12 BRSK2 PGRMC2ABHD14A GABRG3 MIR7-3HGABHD15 LAMTOR5 GTPBP10ABHD16A KLF12 BTF3L4ABHD17B BMP8A SETD3ABHD6 ZKSCAN3 IFT88ABI3 SLC35A1 TM9SF3ABI3BP LOC100289473PKDCCABLIM1 AF007147 MRPS23ABLIM2 PCDHB17 MRPS35ABLIM3 ZWINT MON1AABRACL PACS1 ZNHIT6AC000124.1TCL6 LSG1AC002480.4ANK2 HSF1AC004158.2UBQLN4 FAM136AAC004221.2NKG7 ILF2AC005083.1IGH /// IGHA1 /// IGHD /// IGHG1 /// IGHG3 /// IGHM /// IGHV3-23 /// IGHV4-31EHHADHAC005152.2ADAP1 ELAVL1

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AC005498.3PCDH11X /// PCDH11YTOM1L2AC005606.14HMX1 KBTBD6AC007092.1TSKS HIST1H2BNAC007283.5PLAA SMIM10L1AC007383.3BCAN OLIG3AC007389.3GCFC2 MPZL3AC007405.6CKAP2 /// IGLJ3 /// IGLV3-19 /// IGLV3-19YEATS2AC007773.2UCN WDR3AC007879.2AC007389.3AIFM2AC009336.24GNL3L WDR4AC009495.2MYH11 SMIM13AC009495.4CABYR SDHAF4AC012309.5ITGAM AEBP1AC013268.5HOXB7 DECR1AC016722.1C1orf109 KLF10AC017002.1SUMO3 DOLPP1AC017048.4MNAT1 LMO3AC022007.5IHH CACNA2D2AC022816.2USP24 TDRKH-AS1AC023490.1MAGED1 CREG1AC069513.4VAMP3 GNAI3AC069547.1PPIA SMCHD1AC073343.1USP25 NOP2AC073346.2MFAP5 SCAF1AC074138.3ZC3H13 PKP4AC084018.1TTC27 TRAM1L1AC092171.4NHLRC2 COL4A2AC093063.3RTEL1 /// RTEL1-TNFRSF6BMEG3AC093157.1THBS2 ZNF532AC093375.1SLURP1 TOMM34AC093850.2IFT22 MMP14AC096772.6GPD1L C1QAAC104135.4UQCRC2 LXNAC109826.1DLG5 LINC00543AC112229.7MAGI2 RRP1BAC115522.3MTOR UBE2CP5AC116407.2OR1G1 PMS2P4AC127496.1LRCH4 FAM199XAC132872.2EFCC1 DACH2AC139426.2MMP11 ST3GAL6AC141928.1AGTPBP1 PALMDAC144831.1NASP GABPB1-AS1AC147651.3PKD2L2 STXBP6AC156455.1GZMH RETREG3ACAA2 MMP19 KIF26BACACB RHOT2 ANKRD23ACAD10 SNCB LOC101929479ACADL SSR2 MLH3ACADSB TSSK2 AARSD1ACAP3 ICMT PBLD

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ACAT1 MMP24 SAP130ACBD6 PSMC6 TBCELACE AKAP4 ZNF75AACHE OARD1 CDC7ACKR5 ZNF444 ARAP3ACKR6 EYA2 SCAPACN9 ITPR2 SSPNACO1 MAGEC2 MPRIPACOT11 SLC47A1 WDR45ACOT6 KIF1B MCUR1ACOT9 CROCC CHROMRACOX2 LOC102723620TASP1ACP2 SOCS3 BTRCACPP ZNF226 DGCR8ACSL5 PECR PCDHGB3ACSL6 MAPK3 LRP3ACSS1 WDR37 HMGXB3ACTBL2 HS2ST1 HACE1ACTR1B JTB P3H1ACTR3 ALPL KATNB1ACTR5 UBE2K BRD8ACTR8 RASL12 DDX27ADAM20 GHRH RNF44ADAM33 NDUFA10 KANK2ADAMTS1 DUSP9 ALKBH2ADAMTS4 SULT2A1 PDFADAMTS9 ATG9A ZMYM5ADAMTSL2AAK1 HOXB3ADAR HIPK2 LRRTM4ADCK1 ALDH3B2 P3H4ADCY1 BNC2 SDHAF2ADCY7 PSMA5 CHUKADH1B TBC1D12 IQCB1ADH5 EPHA4 SERINC3ADH6 GPRASP1 AUTS2ADM SAMM50 TMEM216ADORA1 FBXL14 NFATC2ADORA2A EFCAB14 CCNYL1ADPRH LOC102724364 /// SEC22BALDH4A1ADPRHL1 TSPAN12 API5ADPRHL2 RN7SKP150RAB20ADRA1B ASIC4 TRAPPC6BADRA2A NOS3 CNTROBADRA2C APOL3 SCINADTRP RWDD3 RBM18AF064858.8CRYZL1 GALNT11AFAP1L1 SLC35A3 SNRNP40AFG3L2 RAP1B ADCYAP1AGO1 RBM17 MED4AGPAT3 DNAJA1P4 /// DNAJA1P4TSPAN6

Page 264 of 781Diabetes

AGT MOBP AGTAHCY MYO1C DTX1AIG1 FOXC2 LINC00472AIM2 SNAPC2 SRMAK4 CD40 VPS39AKAP7 GATA2 ZNF302AKIP1 TCP10L MFNGAKIRIN2 LTB4R2 RIN3AKR1B10 LOC100506504PKD1P1AKR1C2 TRPC3 LARSAKR1C3 IFNA21 HSPBP1AKR1C4 LRRC59 THEM6AKR7A2 SLC11A2 FKBP3AKR7A3 TMEM14A SETXAL009178.1PPP1R2 TMBIM1AL031666.2GGCT NPM3AL035610.1SGCG HDHD3AL132709.5GLCE NMBAL162759.1CD200 CNIH2AL355149.2LOC101929597 /// TBCDTTYH2AL357673.1RNF11 PDP2AL626787.1ACVRL1 DPP3ALAD PRKCB PPP2R5DALAS2 CLPX NPLALDH1B1 ECEL1 PIANPALDH3A2 PPP1R8 MTSS1ALDH3B1 FA2H C10orf88ALDH4A1 RGS14 DIAPH2ALDH5A1 ERO1L PLEKHH1ALDH7A1 EPB41L4A RNH1ALKBH3 SSH3 ICE1ALKBH4 WSCD2 CSNK2A2ALKBH7 GPI BCORALMS1 RBL2 C11orf71ALOX5AP ZNF277 TARSALPK1 DOCK9 PHC2AMBP FGF21 TMEM273AMER1 UBTD1 TRIM52AMHR2 SCPEP1 DND1AMIGO1 PCDHA10 APBB1AMIGO2 TRIP4 TSC22D1-AS1AMOT BCAM MARSAMPD2 TCRBV12S3GOT2AMPD3 YME1L1 PIK3R3AMT TPM2 TNFSF13ANAPC4 ITM2B SCO2ANAPC5 RAF1 GOPCANGPTL1 ASGR1 TAF1AANGPTL6 SPSB1 C1QTNF6ANKH CHCHD3 OLFML2A

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ANKRD1 IMPAD1 GOLGA7ANKRD11 JMJD1C FAPANKRD13ALUZP1 SPP1ANKRD13DTNFSF9 MED6ANKRD16 CHRNA6 PFKMANKRD18ASH2D3C ADAT2ANKRD22 ITGA8 STAT2ANKRD34ADNAJB14 CASC2ANKRD35 IGHG1 /// IGHG2 /// IGHM /// IGHV4-31 /// MIR8071-1 /// MIR8071-2ESR1ANKRD39 ALPI CCN4ANKRD42 IBA57 ADPRMANKRD6 SH3GL2 CHRAC1ANKRD65 BTNL3 ABHD15ANKS3 LINC01278 ESAMANO2 MTFR1 HAUS3ANO8 MYBPH NFKBIBANP32E RUNX2 PLXNB3ANXA13 LSP1 DHX8ANXA4 RPS6KA3 TRAPPC11ANXA6 SSBP3 PER3ANXA9 NPTXR LARGE1AP000349.1PSG9 C1GALT1C1AP000439.3C5AR2 PRDM16-DTAP000654.4GALNT4 /// POC1B-GALNT4ZBED1AP000769.7LYL1 CDT1AP001372.2LUZP4 MGAM2AP006222.2MRPL34 CHD5AP3B1 TOMM22 NGRNAP3S1 SCARB2 KLHL28AP5B1 GABRQ TIMP1AP5Z1 PADI2 DNAJC11APBA1 NDUFB5 PSME4APCDD1 STAB2 UBA2APEX1 RPS14 SUPT4H1APOA1BP NUP50 HOTSAPOBEC3DNKAIN1 PTGER4APOBEC3F MAGEB4 SEC23AAPOBEC3GTRMT61B ZBTB46APOC4-APOC2ROCK1 BNIP2APOL1 ADK FBXO38APOL2 RPGRIP1 CDK2AP1APOL3 CEP170B FOXJ2APOL4 EHBP1 C1QTNF5APOPT1 GGTLC2 TUBA1BAPPL2 ODF1 ZBTB49AQP1 H2AFZ GYG2AQP12B NFIL3 CKMT1BAQP5 GJB4 PCSK1AQP9 SPTLC1 GASK1BARAP1 F7 PPP1R1A

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ARAP2 SPATA2L FDX1ARF5 DLX6 SPON2ARF6 INSRR CDV3ARHGAP10PTBP2 DNAJB2ARHGAP26POLR3K GPR137BARHGAP31RAP2C NOC2LARHGDIB NHLH2 IFRD2ARHGDIG RAB3A GBGT1ARHGEF17 RBM41 MOV10ARHGEF35 HRG RABL3ARHGEF4 SLPI YIPF3ARHGEF5 CHRNA1 SLC25A34ARHGEF9 SNRNP70 CLSTN3ARID5A RHBDL1 ZNF672ARL16 CPN2 LOC101929550ARL4C MIR6787 /// SLC16A3MRPS31P5ARL5B SORBS1 KIAA1614ARL9 CYP4F2 LUZP1ARMCX5 DHRS2 SPTAN1ARNTL2 TERF2IP TSTD2ARRDC3 ARF5 LYZARSE LINC00652 ENPP5ARSG ATP8B3 CLINT1ARSJ RASGRP2 TNKSARSK CNTN2 LINC01106ART3 PRMT1 RNF7ARTN TMEM151BNET1ARV1 CAMSAP2 SNAPC4AS3MT CGRRF1 NUP43ASAH1 SYNDIG1 AMACRASB1 TRIM26 TRIM23ASB2 CRABP2 RDH12ASB4 RSAD1 AGTRAPASB9 XPNPEP2 HHATLASIC3 GUCA2B COL5A1ASPHD2 ACAD10 REEP1ASTN2 HSPD1 MROH1ATAD3C TCN2 FLCNATF3 SOX17 MAP3K11ATF7IP2 EPS8L2 CACNA1AATG4C WDR76 ZBED6CLATL1 MEPE CTPS2ATP11C TNKS ZSCAN25ATP13A4 CSRP3 CNRIP1ATP1A1 FOXA2 DLATATP1A3 GNA15 NAF1ATP1B1 DSCAM SEC23BATP1B2 PSENEN IPO5P1ATP2B3 PALB2 C17orf100ATP4A GCH1 KMO

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ATP5C1 WRNIP1 RSPH1ATP5D MLLT11 PCDHB16ATP5G2 BZW2 CD40ATP5I MLX BMS1P20ATP5L DRG1 DUS3LATP5O SPTBN5 AOPEPATP6AP1 BCL2L14 CCDC88AATP6V0B ABCC8 CHD7ATP6V1B2 CDK8 SRSF10ATP6V1H CD5L CD81ATP8B1 GYG1 ADD3ATPAF2 FOXN3 KLHDC8BATPIF1 LSM7 HMGN3ATXN2 TMEM230 CDK12AUNIP LHX3 NBL1AURKB TMEM41B TAF1B2M CASC3 /// MIR6866TLN2B3GALNT1 PARP12 TBC1D2BB3GALT2 MRPS10 MAP7D1B3GAT3 CERK RANBP2B3GNT1 FARS2 SF3B5B3GNT2 MARCO JMJD4B3GNT8 PTPRS LSM12B3GNT9 RHCG AGPAT5B4GALNT2 ATP5C1 LCP2B4GALNT4 UNC5B PMS2P3B4GALT1 COPS4 ZSWIM8B4GALT5 EPHB4 SLC25A22B9D2 PI15 DHCR24BAALC SNHG3 /// SNORA73ANAP1L4BAAT C17orf75 IGFBP7BACH1 SCNN1G CHMP5BAG1 CYP11B2 CASTBAIAP2L1 EIF2AK2 TMEM44BAK1 IL4 MRPS22BANK1 PDE1B CLCN3BATF2 RFXAP PLOD2BATF3 ABCD1P2 /// ABCD1P2MATN1-AS1BAZ1A ARPC4 /// ARPC4-TTLL3 /// TTLL3EXOSC9BAZ2A CD302 /// LY75 /// LY75-CD302FAM102BBBC3 SLN ING4BBIP1 ID3 SYNJ1BBS7 PCK2 KTI12BCAM CACYBP MYADMBCAR1 GALNT12 BGNBCAT2 ADRB3 GALK2BCHE ALOX12P2 SOX5BCKDHB PIGG PIGLBCL10 CYB5R4 AZI2BCL2 TMEM180 ARFGEF1

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BCL2A1 NSD1 ASB4BCL2L14 SHARPIN CHMP2BBCL3 DCHS2 VANGL2BCL6 COL7A1 PECAM1BCL7C KIF21B AK2BCL9L RANBP9 LY75BCO2 NXPH4 ARHGEF10LBDKRB1 S100PBP BTCBDKRB2 MRPL2 TBKBP1BEST1 CFHR5 DUSP4BEST3 SEMA6B BBS2BEST4 CACNG5 APOL2BEX4 ATXN10 UNQ6494BHLHE41 RNF115 ALG3BICC1 DKKL1 SELENOFBIN3 SLC17A9 ATF2BIRC3 CASP10 NOL8BIRC5 COQ10B SHKBP1BIRC7 PRPSAP1 DPP8BLMH NRP2 CLNS1ABLNK MSH6 LOC154761BLZF1 PLXNB3 HCP5BMP2 GALNT8 /// KCNA6FMNL3BMP4 CREB1 SNAPC3BPGM LILRP2 CDC25BBPHL SMG9 APCDD1L-DTBPIFA1 GUCY2F EIF2S1BRD4 BRD7P3 GSAPBSPRY HNRNPD ZNF408BST2 XRCC3 SLC35F5BTBD2 FHL5 TMPRSS6BTBD6 RALGAPB PYM1BTG1 ABCA4 COL5A2BTN2A1 PARK2 ZNF567BTN2A2 ORC2 RSBN1LBTN3A1 DIRAS3 FAM122ABTN3A2 ARIH2 MORN1BTN3A3 LYVE1 EFCAB6BTNL8 KRCC1 TMEM88BUD31 CASQ2 VPS51BX088651.1STARD8 NDUFA5BZW2 CEBPE STON1C10orf128FKBP1A /// LOC101929368TSPAN1C10orf32 C9orf91 SWI5C11orf1 CYP2A6 EXTL2C11orf24 KDM4A SLC23A2C11orf31 KHDC1L GNL1C11orf74 PTPLB ARHGEF1C11orf83 KIR2DS1 CAMTA2C11orf92 AK022030 /// TROVE2MOB2

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C11orf93 MYCN SPACA6C11orf95 BEST2 COL6A2C12orf10 AP4S1 RASGRF1C12orf74 MLF2 RNF13C12orf75 EPHX3 INSIG1C14orf105 MGAT3 PER1C14orf37 MTMR10 C16orf72C14orf80 ID1 RCOR1C14orf93 SHPK /// TRPV1RAPGEF1C15orf27 TMEM30A TRPM3C15orf48 GRM5 MGRN1C15orf52 CDKN2C GNASC15orf54 PCDHA5 ZNF391C15orf59 REV1 BRD4C16orf46 ARHGAP22TUBGCP2C16orf59 TSC22D2 PDCL3C16orf80 MMP8 KPNA2C16orf95 SOD3 PEX19C17orf76-AS1LCMT1 PLPP3C17orf89 NR0B1 PPP1R16BC17orf96 MTMR14 TIE1C18orf32 KCNK2 CDKN1BC18orf8 GABRR1 NALCNC19orf48 CPNE6 ITPKBC19orf66 NOD2 HSPB1C1GALT1C1VPS13C PRPF4C1orf127 NCR1 MRPL16C1orf158 ISG20L2 SPATS2C1orf159 DDC PAIP2C1orf192 CSGALNACT2BOCC1orf198 ZBTB17 TAPBPC1orf204 TAS2R4 NUMBLC1orf213 ADD2 TSEN54C1orf227 IGF2-AS DHPSC1orf229 SOX10 TMED5C1orf233 TSPYL4 VDAC2C1orf35 HOXC13 CNOT1C1orf50 DARS2 TMCO3C1orf61 NACA TMEM177C1orf85 MAGEA12 SNHG29C1QB LINC00216 GLI3C1QL4 PMFBP1 ADGRA3C1QTNF1 NRN1 STBD1C1QTNF5 FUT7 ZNF195C1R PALM LOC103611081C1RL A4GNT CALHM2C1S PIP5K1C ZNF775C20orf112 RNF111 TMEM267C20orf141 COMMD3 ARHGEF15C20orf195 ID2 CD72

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C20orf197 DRD4 VRK3C20orf27 TCP10 SEMA6AC21orf33 PSG6 TCERG1C22orf29 PIWIL2 SLC39A3C2CD4A KTN1 TMPRSS2C2CD4B CHGA DMTNC2CD4D APH1A SCHIP1C2orf27B HNRNPDL SERF1AC2orf72 ASNSD1 RBM3C2orf81 AVP PRCCC2orf88 SIGLEC8 CAMK1DC3orf18 SULT2B1 SLC8B1C3orf38 WNT1 C1orf216C4orf19 FAM186A SOD2-OT1C4orf27 ZBTB11 LOC101927550C4orf32 OR12D2 GPR153C5 ERCC4 TJAP1C5orf15 LGI2 GRAMD1AC5orf27 DTX2 /// LOC102725292NLRC4C5orf30 MAP1B TRAK1C5orf46 BCAP29 LINC00957C5orf56 MTUS1 DRAM1C5orf63 PDS5B KARSC6orf106 NYX ARAFC6orf123 NDUFB4 PAPSS2C6orf136 AK021537 WDR37C6orf203 OPA1 LINC01881C6orf52 OR2H1 DHRS11C6orf57 GCKR NUFIP2C7orf10 UBA3 ZNF181C7orf41 FAM98A TP53TG1C7orf49 ARMC8 SMIM5C8orf4 FAM206A SORT1C8orf47 CAMK2A NAGKC8orf49 PCMTD2 ARSEC9 DAZAP2 YDJCC9orf116 SETD3 KIAA0930C9orf40 ARHGEF4 CASP6C9orf96 GLP2R HLXCA8 PTEN ZNF738CACFD1 RPL10 /// SNORA70CD4CACNA1A SIPA1L3 ZNF394CACNA1D AC007967.3 /// RBMY2TP /// RBMY2TPHCN2CACNB3 SKP1 GOLGA2P7CALCOCO2 SH3GL3 PHB2CALHM2 MTHFD2 LINC02449CALML4 HTR3B RBM33CAMK2G IGHA1 /// IGHG1 /// IGHM /// IGHV3-23 /// IGHV4-31UBAP2CAMK2N1 PUM2 BRD1CAMKMT ZNF669 TNFRSF11B

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CAMLG POMT2 MIR100HGCAMSAP3 MTERF3 G6PDCAPN13 ODAM GAPVD1CAPN2 PRRX2 SSTCAPN6 PARK7 UBE2V2CAPN9 RHAG ACAD9CAPS PPY2 ADGRL4CAPSL CETN2 LOC100652758CARD6 SNAP91 ZSCAN22CARHSP1 NDUFAB1 FBXO34CASP1 PNMT SCN1BCASP10 ESPN DDAH2CASP4 LOC100131510FBXO48CASP5 SMARCE1 CTSZCASP6 LSM2 GCGRCASP7 HIST1H3F GLT8D1CASR ARMC6 ATG14CASZ1 RBX1 FAM3CCAT ALPK1 COP1CATSPER1 MUC6 TENT5ACBR3 HSPB7 GLRX3CBX1 ETNPPL MAMDC4CBX2 APBB1IP EGR2CBX6 ABHD4 TUBE1CBX8 MCOLN1 SLC35A4CC2D2A PAXIP1 ALG13CCAT1 IZUMO4 IFI30CCDC102BLINC00094 HAND2CCDC107 USP4 ARRDC2CCDC108 PURG OTULINLCCDC110 TULP4 AARS2CCDC125 SCAMP4 SGSHCCDC127 CTDSP2 DUSP18CCDC147 OSGIN1 BAZ1BCCDC148 NDUFAF4 ZNF85CCDC151 IFNW1 PCP4CCDC152 SCN4A NTMCCDC24 LIPE KRIT1CCDC28B CCDC81 ELF3CCDC41 SRRM2 ICA1CCDC57 FNBP1L NRSN1CCDC68 NUP85 OATCCDC71L SAGE1 N4BP2CCDC74A MRPL52 PDIA3CCDC81 CCL1 PDXKCCDC85B ATP2A1 IL17RECCDC85C GPR161 MXD4CCDC86 GAST PSMA5CCL2 CPNE7 RNF170CCL22 ACKR2 KCNC4

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CCL3 ACOT11 RRAS2CCL3L1 P2RY4 ADGRA2CCL3L3 TCTA ID3CCL4 FOXL1 FAM78BCCL4L1 DCAKD EXOC3L2CCL5 RETN SLC16A10CCL7 PRPS2 LRCH3CCL8 LTB ARFIP1CCNA1 OCLM CCDC30CCNB1IP1 ACHE ZFAND3CCNI2 MORF4L1 NOTUMCCNJL PRR34 EIF2ACCRN4L NONO EMC8CCT3 C7orf69 HACD2CD163 YY1 APCDD1LCD164L2 ABLIM3 PBRM1CD180 LMAN1 MUC1CD248 FKSG49 RAI1CD274 POU5F1B LOC285638CD2AP EFR3A ORAI3CD36 SLC12A5 LOXL4CD38 HMGN1 PACS1CD40 SLC28A2 SNX21CD46 PLEKHB1 GSTA1CD47 RDH16 SMNDC1CD48 ADAM10 STYXCD6 RANBP17 SHC1CD68 LOC101929336 /// RIF1CRKLCD7 LOC101929078CREMCD74 NMRK1 CPT1CCD80 ASB12 /// MTMR8SPTBCD82 PIGA ENTPD3CD83 POLR1D BHLHB9CD9 NBPF10 /// NBPF11 /// NBPF12 /// NBPF14 /// NBPF15 /// NBPF20 /// NBPF8 /// NBPF9KHNYNCD99L2 YBX2 CLEC16ACDC16 MED28 TYSND1CDC25B TRIM10 LHFPL6CDC42BPG HADHB CD300ACDC42EP2 TP63 KCTD21CDC42SE2 FRMD4A HIF1ACDC7 MIA KCTD11CDCA3 NKX3-2 MGAT2CDH24 BPI /// LOC149684DIPK2BCDH5 CDKL5 PHLDB1CDH6 EHMT2 NAA30CDHR2 GRIP1 UCP2CDIP1 ASGR2 EPCAMCDK10 CD6 MVPCDK2AP1 PAPPA2 HMCESCDK5 SLC1A7 STIM1

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CDKL2 RAPSN ETV6CDKN2AIPNLZNF536 ZBTB44CDKN2B LOC101928830 /// LTA4HPRR16CDR2L CIITA SNTB2CDS1 EPHA1 SHOC2CEACAM1 PAX3 PIGBOS1CEACAM3 TRPM8 LMO1CEBPA PIBF1 KCNJ2-AS1CEBPB RRAS2 CICCEBPD IMPG2 KHSRPCEL SLC9A8 ACADMCELA3A GK-AS1 /// GK-AS1GAREM2CELSR2 TMED1 RIPK3CEMP1 OPRD1 FFAR4CENPBD1 SENP5 ERCC3CENPE BTBD7 MAN2B2CENPJ MAG SLC16A9CENPQ INPP4A CD55CENPV AUH SAP30BPCEP41 NAB2 MST1P2CEP55 MPP1 ZBTB11CERK B4GALT7 LOC646903CERS1 AHSP STX12CERS4 UFD1L FARP2CFB BRS3 URB1-AS1CFH MAOA PSMC2CFHR1 AKT2 KBTBD8CFLAR CDH7 PIK3R1CFTR TMEM186 LY6G5BCGREF1 UTP11L C2orf72CHAD TRAPPC2 /// TRAPPC2P1SF3B1CHCHD10 RPS6KA4 TNFAIP1CHCHD6 POLR2K FGFR1CHD7 CCT6B VPS50CHI3L2 EPN1 PRRT1BCHID1 TRAPPC9 FGFR4CHMP4B PRMT8 LOC728739CHMP5 SGPP1 CELF2CHN1 OMD FOXF2CHPF BRD2 ILDR1CHRM3 LARP7 SGSM2CHRNA4 OPRK1 C14orf28CHST14 TMLHE CDH10CHST2 WNT7B SARAFCHST8 CACNG2 PCBD2CHST9 F2RL2 ADD1CIB1 Igk FCGR2ACIITA ZC3H3 DUSP28CINP PLCG1 S1PR1CIR1 CTSZ TMBIM6

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CISD1 PHYHIP GLACISD3 TPSB2 CCDC163CKAP4 HOXC4 RBM22CKAP5 APOB UTP3CKB ZNF143 CAPN7CLC CCL13 PPP1R2CLCF1 PGLYRP4 AP1G1CLCN4 CD33 SCPEP1CLCN7 PIGH ERI3CLDN10 TINAGL1 ACP2CLDN11 KLHL24 CCDC102BCLDN14 SRD5A2 MTF2CLDN18 CLSPN UGT1A6CLDN6 HAUS7 /// TREX2C2orf49CLDN9 PCMT1 AKAP1CLDND2 NGDN HNRNPA0CLEC2D NBEA ITM2CCLEC4D MLN LEPROTL1CLIC1 LOC101930405ZNF133CLIC2 C3orf27 ASB6CLIC5 FMO2 TMEM17CLIP3 FOXN2 CD5CLSTN1 CCNT1 PTP4A3CLSTN2 IL9R PRPF3CLTA PRCP SHTN1CLUL1 GRK1 SGK1CMBL MYO9A NEK10CMPK2 CTPS1 FOXP4CMTM4 RABEP2 TFEBCMTM5 UGT1A1 /// UGT1A10 /// UGT1A4 /// UGT1A6 /// UGT1A8 /// UGT1A9SLC18A2CMTM6 SPSB3 ATRCMTM8 TCP11L1 BAG3CNFN RCVRN STEAP3CNGA1 DLAT FNDC10CNIH3 GNAI3 C19orf81CNNM3 ACE HNRNPFCNP SMAD5-AS1ZNF749CNPY4 HOXD3 /// HOXD4 /// LOC401021CASTOR2CNTFR RHPN1-AS1TRIM3CNTN1 JPH2 TVP23BCNTN3 EPHB1 PIBF1CNTROB ITGA2B CALHM5COA3 MIR600 /// MIR600HGPGRMC1COG4 C1QA NOD1COL15A1 DHX58 ERICH2COL8A2 MTNR1A SAMD9LCOLEC11 FSCN1 QTRT1COLGALT1 FAM60A KLHDC3COLGALT2 STAG2 KYCOLQ KIR2DL1 YIPF1

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COMT MARK1 ARHGAP27P1-BPTFP1-KPNA2P3COPG2 PTGIR PRKRACOPRS RPL3 CLYBLCOPS3 TOPBP1 TIMM23B-AGAP6COPZ2 CCPG1 CCNCCOQ10A DFNB31 RADILCOQ3 SLC12A9 MYLKCORO6 BC069782 /// STAMBPL1ARSKCOX4I1 MEF2B /// MEF2BNB /// MEF2BNB-MEF2BMYSM1COX5A MAPKAP1 TFDP2COX6A2 MZB1 NTHL1CP MSTO1 /// MSTO2PPIK3C2ACPLX1 KRT32 LOC100505715CPXM1 FBXO24 USP12CPXM2 DR1 SSBP3CR1L PLAC4 ZNF503CRCT1 GPR31 MSI2CREB3L4 PAQR3 LINC00683CREBL2 PLCB1 ATMCRIPAK TNFSF18 NSMAFCRLF1 HCAR3 B3GALT5CRNDE PRDM10 WIZCROCC GAP43 MITFCROT DAPP1 PLXDC2CRTAC1 HSPA9 HMGN2CRTAP YWHAZ SARDHCRYAB P2RY6 LCAL1CRYM CLIC4 C9orf131CRYZ GSN-AS1 MCCCSE1L SMAD2 CAMKK1CSF1 RRAGD NFKBIL1CSF2 FUZ IL6R-AS1CSF2RB RAPGEF2 SDK1CSF3 SP3P PHF1CSF3R ERGIC3 RNF216CSMD2 MPZ SGCDCSRNP1 ZC3H7A IFT43CTA-126B4.7ST3GAL6 ZNF74CTAGE15 HOXB3 DDX41CTAGE4 SAYSD1 PRDX6CTAGE6 PTPN12 RFC2CTAGE8 SIX5 EFNA5CTAGE9 PCYT1B CCDC9BCTB-31O20.2YTHDF2 MTFR1CTB-31O20.9ABCC4 WDR13CTB-43E15.3SLC17A6 SYNE2CTB-75G16.3LAX1 ZNF569CTC-228N24.3SARAF ACP5CTC-428G20.3TEAD4 IPPCTC-462L7.1LOC100505534SLC39A10

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CTC-527H23.3PLD2 ANAPC5CTD-2001E22.2IKZF3 ZBTB7CCTD-2008P7.9TLX3 RPS10P7CTD-2044J15.2MAGEC3 PHRF1CTD-2135D7.5HTR7P1 APTXCTD-2139B15.2IL2RG APMAPCTD-2162K18.3LOC101928717 /// SLC19A1SLC7A8CTD-2184D3.6IQGAP1 CEP162CTD-2195M18.1MIA3 SPOPCTD-2339F6.1CTAGE11P C16orf70CTD-2554C21.2ALOXE3 ZNHIT2CTD-2561B21.11YWHAQ CENPVCTD-2587H24.10FLI1 APOA4CTD-2619J13.14ZNF446 CHL1CTD-2619J13.17TAF1 RAPGEF5CTD-3193O13.11DHDDS NBPF3CTGF PIP5K1B LOC101930085CTIF FGR CYSTM1CTNNBIP1 HARS /// LOC101928623ALDH1A1CTNNBL1 XAB2 CRCPCTRC PELO NGLY1CTSC MAP4K2 SSTR5-AS1CTSD APBA1 GOLGA6L5PCTSF ATN1 NUDT11CTSH SLC6A2 PIGTCTSO MED25 HAPLN4CTSS WASF3 DLC1CTU2 ITGB3 ADAM19CUEDC1 DSCR3 ASNSD1CUEDC2 GRIK5 CFHCUL2 GTF3C2 ZDHHC12CUL4B IMPACT ROBO1CUTA RSPH6A DYRK3CUZD1 TIMM17A NRBP1CWC15 NPM1 FMO4CWC27 BTBD18 PERPCX3CL1 LDLRAD4 FAM107ACXADR MAPK6 THBDCXCL1 HGH1 FAM168BCXCL10 EIF2AK1 CLDN11CXCL11 WNT11 NID1CXCL16 MS4A5 F2RCXCL2 NR2E3 TPI1CXCL3 TOX DDX56CXCL5 IRX4 CAPN10CXCL6 HMGN4 RPS6KB1CXCL9 DLX4 SOX4CXCR4 HOXC10 TMEM204CXCR5 NUFIP1 GPR160CXorf36 EPS15 SAP18

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CXorf49 ZNF747 /// ZNF768PARP1CXorf49B PRPF39 SLC39A1CYB561D2 HR SAMD8CYB5A APBB3 /// MIR6831COL5A3CYB5RL SLIRP TBL3CYBRD1 TSNAX NEFMCYHR1 BTG3 CALM3CYLD ARL8B BPHLCYP21A2 MBTPS1 CWF19L1CYP24A1 PSMA2 CALML4CYP26B1 PRRG3 TDO2CYP2U1 ACPP PTPRDCYP39A1 SAMD4B CCEPRCYP3A4 FASLG NKX2-3CYP3A5 HPD ATP5IF1CYR61 PAIP1 RMC1CYS1 HOXA1 BMP1CYSLTR2 RAD17 PLEKHA5CYTH3 ELMO2 PTPRSDACT2 MAN2A1 TMEM62DACT3 ATP6V1C1 PCDH18DALRD3 KIR2DL2 ANKHD1DANCR KIR2DS3 CALD1DAND5 HTN1 KCNJ14DAO ABCC10 TRAPPC8DAPP1 SPDEF SDHBDARS2 ACTL6A ZNF41DBH MKRN7P NDUFAB1DBN1 ARFGEF1 RWDD4DBNDD1 CCL4 UBXN11DBP TMEM35 COX6B1DCAKD MRC2 FTODCBLD2 EIF4A3 STAT3DCLK1 TEK OSTF1DCLK3 SAP130 NPC2DCLRE1C UBE2V1P9 /// UBE2V1P9LIN7ADCTN2 GJA8 DNAJA2DDAH1 LOC100506124 /// TTC21BTMEM199DDB2 APOL6 UGT2B7DDC GPR162 PCDHB10DDHD1 NRIP2 LRPPRCDDN CARM1 ISOC1DDO SEMA3G ITGBL1DDR1 TMEM38B ZCCHC18DDX27 UBE4A DGCR2DDX42 RYK MAP6DDX58 OR3A3 ZNF334DDX60 CNTNAP2 CYB5RLDEAF1 MED1 TIGD6DEFB4A ROBO4 NPAT

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DEFB4B MAP1LC3CZBTB11-AS1DENND2C AQP6 APOBEC3FDENND5A DSCC1 ZNF747DES ITGB7 PDE3ADESI1 ACYP2 /// LOC101927144RRM2BDFNB31 E2F5 SNAPINDGCR6L EIF3H NRGNDGKG RARRES1 ATG9ADHRS11 DLX2 SCARB1DHRS4 TEX13B MAP4K4DHRS4-AS1CLCN4 PAX6DHRS4L2 CTB-176F20.3PRMT6DHRSX GDNF PLIN3DHX58 CCDC91 C8orf37DIAPH1 SUCLG1 WDR82DIRC1 SSTR4 LNPKDLEU1 CTD-2269F5.1CD36DLL4 CD160 MBTD1DMGDH HSD17B4 SLCO2A1DMPK IL4I1 /// NUP62KINDMRTA2 GGA3 XPCDMTN KCNH1 SNHG15DNAI1 NPHP1 MTBPDNAI2 BTN2A3P CCN3DNAJA1 CHD2 ATP2C2DNAJC22 GTF3C4 ULBP1DNAJC4 LDB3 AAR2DNAJC5 RPL23A IP6K2DNAL4 RP11-255C15.3BNIP3DNPEP PPP1R7 INTS6LDNPH1 PPP3CA WDR75DOK4 ETV2 LOC283335DPF1 PYGL GALNT14DPH5 LHPP FOCADDPP7 CYP2C9 DEAF1DPY19L2 ERCC3 FDFT1DPY30 ACADS ABCF2DPYD FCGR2B MAP10DPYS CASQ1 ABHD16ADRAM1 RORC ZDHHC4DRAXIN ALX3 EXOC3-AS1DROSHA HLA-DRB1 /// HLA-DRB1OMA1DSC2 PDE6A USP49DSCAM RNF41 RGS14DSCC1 RP5-882O7.1FAM43ADSE MDN1 NFIL3DSPP GUSBP11 GLMPDSTN ERV9-1 ASNSDSTYK NPIPA5 /// NPIPB3 /// NPIPB6 /// NPIPB8SMN2DTD1 FECH AVPI1

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DTD2 MPHOSPH6GLSDTL BPHL LOC107985939DTWD1 LOC102724905PAG1DTX2 KRT8P17 /// KRT8P17SLAIN2DTX3L HEXA HOMEZDTYMK ZNF629 PAM16DUOX1 B3GALT5 UBXN6DUOX2 MASP2 TANGO6DUOXA2 TRIP12 MYO15BDUS1L FBXO9 ALKBH7DUSP1 PTP4A1 DHX38DUSP10 HOPX PPP1CBDUSP14 AMN GRIA2DUSP2 PSIP1 ADAMTS7DUSP26 CNTD2 EI24DUSP6 EFCAB1 PRPF38ADYNLT1 CKMT2 DAPK2DYSF ACTN3 PCAT19EBI3 IGLV1-44 UBA1EBPL PARP4 EDRF1ECH1 CAPN3 ADAT1ECHDC2 CLPTM1 PCDHAC2EDC4 WDR1 U2AF1EDEM2 SLC22A18ASPHIPEDN2 ZCCHC8 ACAD11EDN3 FAM3C CEBPBEEF1B2 ZNF146 TNFRSF10BEEF1G TNFSF11 EFCAB14EFCAB3 SHMT1 MAPK11EFCAB4A GML BCL9EFCC1 CTBS PPP1R14CEFHC2 FBXW2 OARD1EFHD1 P2RY2 MARCHF4EFNA4 DPY19L4 C20orf27EGFL8 CBX2 ZDBF2EHD1 LRFN4 SEC61BEHD4 AC012065.7FGAEHHADH LEF1 DUSP8EID3 CDH16 CHP1EIF2A RRN3P1 NUDT16EIF2B3 ARHGAP29UGGT2EIF3A SQRDL ADAMTS17EIF3E GRM4 RO60EIF3F ASH2L MDC1EIF3J-AS1 RDH11 ARHGDIBEIF3K TTR ASIC1EIF3L ATP5O PRR3EIF4EBP2 PSMF1 SCO1EIF5A EPS15L1 RPUSD4ELF3 LOC100288974 /// MBL1PSSR1

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ELF4 MYO1F KANK3ELK1 CDC25C C14orf132ELL FAM110D PARP16ELOVL7 CEP192 CBWD1ELP4 NDUFS1 SLC9B2EMCN ZNF202 KLHL11EMID1 PPP1R16B TNS3EML6 C8orf44 CSRP1ENDOG SCN2A CDC27ENHO GPATCH2L LIN7CENKUR TNFRSF10CPUM3ENOPH1 EMCN IFNGR1ENPP7 DAO CNTN1ENTHD1 RASA1 KDM5CENTPD2 KDM1A H6PDENTPD3 SLC39A8 THAP11EPB41L4B CHMP2B ST8SIA4EPHA1 ZNF132 NDUFB4EPHA2 PPP2R4 LSM2EPHA4 CEP164 SIN3AEPHB2 KCNC2 TMEM33EPHB6 RPS4XP2 /// RPS4XP2CASTOR3EPHX2 SSBP2 OPCMLEPHX4 RNF7 ARG2EPSTI1 HPSE2 IDNKERAL1 C19orf80 RTL5ERAP1 C2orf54 ALG11ERAP2 ATP6V1G1 EVA1CERCC2 FERMT2 COG2ERCC5 MPP5 CCNYERI1 AQP5 PPP1R8ERICH2 GPR137 FAT1ERLIN1 SAP30BP MCUBERO1L PCTP GPIERP27 BGN DUSP6ERP44 NAT1 DTX4ERVMER34-1GLRX5 RAB43ERVV-1 SYPL1 PJA1ESM1 LOC101930602 /// SLC14A2ZFAS1ESYT1 ACE2 FRG1HPESYT3 MIR5193 /// UBA7SLC17A5ETFDH PTPRT DCTN4ETNK2 ME1 CYTH2ETS2 COLEC10 TRIM34ETV4 BIN2 MSRB1ETV6 RBMS3 TMEM45BETV7 LSM4 TBPL1EVPL ELAVL1 NECTIN1EXOC3L1 ATF6B /// TNXBSLC6A6EXOC3L4 CRK ZNF204P

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EXOC6 TBX4 PHF11EXOSC5 ADCYAP1 OLFML2BEXTL2 PCDHA5 /// PCDHA6ST3GAL5-AS1EZH1 ELAVL3 TTKF11R ATG12 PRR15F13A1 CSNK1A1 POU2F1F2RL1 RNASE3 GIPC3F7 TP53TG5 PIGXF8 ZMYM6 /// ZMYM6NBRBMS1FADS6 NAT6 POLR3GLFAHD2B ZNF609 GLG1FAM101B PCOLCE2 LOC100286925FAM102A ARG2 TCP11L1FAM105A ELFN1 TBC1D1FAM109A PRIMA1 MKRN1FAM110C RP1-212P9.2SECISBP2LFAM114A2FAIM2 PRSS16FAM115C PTPN3 MED1FAM117A TSHR PLS1FAM117B RASSF10 SLC35C2FAM122C CTSV RPL17-C18orf32FAM124A ACOT13 HES1FAM124B RP11-320H14.1SLC66A3FAM133B DHRS7 ABITRAMFAM135B NDUFS1 FRAT2FAM136A MRPL18 MBLAC1FAM159B MYLK3 ZSCAN32FAM171A1HCN4 CA5BP1FAM171A2KCNAB2 TTC25FAM173B ENDOD1 STC1FAM174B RDH10 MSANTD2FAM177A1NDUFS4 CACTINFAM179A HS6ST2 KCTD5FAM184B NTPCR MAP3K13FAM186B SLC26A4 SLC37A1FAM188B MPC1 CZIBFAM189B FAM47E /// FAM47E-STBD1 /// STBD1RAC3FAM195A TMEM37 SYT17FAM195B SDHB UNC13AFAM198B ADH5 SLC22A5FAM19A4 FTL ZSWIM5FAM200B GABRA2 FESFAM203A C11orf87 ADPRHFAM211A DQ592442 NUDCD1FAM211B COMMD1 GASAL1FAM213A MRPS18C LCA5LFAM219B GREM2 MAP3K8FAM228B RPA3 VAT1FAM26F SRXN1 SYMPKFAM46B NHLH2 ARPP19

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FAM50B EPB41L1 PIK3CGFAM53A SMIM13 RAD17FAM63A TOMM20 PKIGFAM76A TMEM126BTMEM87AFAM78A PCCB PDE3BFAM78B MRPS33 PDE11AFAM81A LOC101927734THAP7FAM90A1 ATP5F1 RBM19FAM92A1 ATP6V1H TPP2FAM98B SLC2A1 RAD23BFAM98C B4GALT4 ACTBFAS CKS1B SLC16A6FAT1 TMEM126AZNF469FAXC PSMC2 BABAM1FBP1 CHODL PUM2FBXL16 PAICS WDR33FBXL4 PSMA3 PPP4R3AFBXO24 PDP2 UTP14AFBXO25 GRIN2D NEURL1FBXO6 NDUFV2 PPP1R12CFBXO7 C18orf8 PIRFBXW9 OSTF1 SH3PXD2BFCAMR NASP /// NASPZXDAFCER2 SMAD9 CROCCFCGR1A SNRPD2 NOL9FCN3 PGRMC1 DERAFCRL4 NIF3L1 IGF1RFCRLA LOC148696AUHFEM1C IMP3 RTN2FERMT1 MBNL2 /// MBNL2MKNK1FEZ1 FAM193B SIK1FFAR2 RAMP3 SIK1BFGB CHMP2A TMEM35BFGD1 LONRF3 RNF25FGF1 MRPS30 STARD9FGF10 LSM3 PTGISFGF14-IT1 PPP1R1A DHRSXFGFBP3 NCKAP5 SPIDRFGFR3 RPL36AL MYRFFGFR4 TRMT10C PLXNA1FHDC1 SNAPC5 NINFHL1 DIAPH2 OLR1FHL2 RRAGD PPDPFFHOD1 SPAG7 HMGN5FHOD3 PELO FCHO2FIBIN TAMM41 TVP23CFIGF TUBB2B MS4A7FILIP1L DGUOK MRPL10FJX1 OPA3 PTPAFKBP1B MLLT6 DGKH

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FLNA CMAS GIMAP4FLNC TMEM27 SLC25A39FLRT2 PPCS SLC44A3-AS1FLVCR1 C14orf119 ZNF668FLYWCH2 METTL5 NDUFB6FMN2 IER3 TRIM28FMNL2 C11orf73 ACOT7FMO5 PRR26 ZMYND8FN3K LOC102724814GTPBP1FNDC4 TWF1 BBXFNDC5 SOD1 PTPRBFOSL2 PRR13 COLGALT2FOXA2 MRPS23 LRFN5FOXP4 ATP5O SNX15FOXRED2 RAB30 UFD1FOXS1 EIF2B3 ASB9FPGT DKK3 MAU2FRAT1 YPEL1 LCMT2FRAT2 UTP11L ABALONFRMD3 CCT4 SLX4FRMD4A LINC01116 ARAP1FRMD6 SLIRP STARD4-AS1FRMD8 NDUFS5 /// RPL10RAD50FRRS1 TSPAN1 PGAP2FRS3 MDH1 STAU2FRYL HNRNPA0 ASB7FRZB INPP5D SPRY1FSCN1 CCT2 LINC02606FST TTI2 EIF4BFSTL3 LRTM1 GALNT12FTH1 SCO1 GUCY1A1FUNDC1 COX11 ENC1FUT1 SNX11 LOC100506100FUT5 GCC1 FAR1FUZ ANKRD20A12P /// LOC101059949 /// LOC101060632 /// LOC101927345GTPBP8FXN KIAA1045 ACAT2FXR2 ATP5H IGSF8FXYD6 TMEM60 CSPG4FYB TMEM59L TUBA4AFZD2 EFTUD1 LINC01833FZD5 PSMA1 PTPN9FZD9 MED27 EP400G0S2 RPL26L1 CCDC117G6PC2 APOO STX16-NPEPL1GABARAPL1ODC1 SHISA6GABRD SPTLC3 CFAP298GABRG2 MYOM1 VWFGALK1 POLR3K SNTB1GALM TACC2 POMT2GALNT11 FAM71C MARCHF5

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GALNT16 MICAL1 ZNF593GAMT TUBA1B ZNF286AGAS6 ANKRD46 /// GAPDHP62CHIC2GATA6 PTPRU PDLIM4GATA6-AS1DBI LINC01137GATM RIMKLA BEGAINGATS KIRREL3 GTF2E2GATSL3 PLA2G16 C22orf23GBP1 CRHBP DMAC2GBP2 CXXC5 TAGLN2GBP3 AP5M1 MAOAGBP4 PROCR MEIS2GBP5 PRKCD DNAJB5GBP6 PBDC1 FOXQ1GBP7 TNFRSF21 IFT52GCHFR LOC100506411ZCCHC8GCNT3 MRPL1 SRBD1GCSH BOLA3 LRIG2GDF11 DARS2 PLCH2GDF5OS PPP2R5A NAT10GDF6 EFCAB11 GATMGDI2 LOC102725454RASD2GDPD1 FFAR4 NCKAP5GDPGP1 TIMM8B CYP26B1GFPT2 ARPC1A SYCP2LGGCT MRPL47 TMEM101GGNBP2 ABRACL KLHL13GGT1 NOD1 TIGARGGT2 PSMB7 HPS1GGT6 SATB1 TPCN1GGTLC1 GOT1 PCDHGB6GGTLC2 SLC9A3R1 LRRC6GID4 DHRS7B SQLEGIMAP2 RHBDL3 BTAF1GIMAP7 TCEB1 AKT1GINS2 EMC3 ZNF124GIT1 CHTOP SMYD3GJA4 CCT8 MAPKAPK5GJB1 CATIP-AS1 IQGAP2GJB2 FGFR2 DYRK2GJB5 PSMC1 ROBO2GJD2 FASTKD5 RAB5IFGK MRPS36 TMEM233GKAP1 MRPS22 STRA6GLI1 CCDC167 COQ8AGLMN ALS2CR11 FAM210AGLO1 MDH2 KLLNGLOD5 SERPINB8 NFATC3GLRA1 ATP1B3 DZIP3GLRB EIF4A3 ST6GALNAC4

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GLRX LACTB2 ARHGAP25GLRX5 LOC100507654SPAG9GLS2 MARS2 SYT7GLT8D1 FH ACAA1GLT8D2 NDUFB9 POMGNT1GM2A NSMCE2 SAMHD1GMFG PDCD10 COPS4GMNN AKT1 HNRNPDLGNAI1 PIGH NCAPGGNAS NDUFB6 MARCKSL1GNB5 ZBTB8OS RAP1GAPGNE BTBD10 DLG5GNG10 EAF2 USP3GNG7 MRPL14 NOTCH1GOLGA8S TBC1D5 CDC16GP1BA MPHOSPH10METTL26GP2 TARS DDX60LGP5 NCBP2-AS2RPRD1AGPBP1L1 NOTUM SAPCD2GPC1 SEPT8 POLR2KGPD1L CMSS1 CTU1GPLD1 UBQLN1 CAVIN2GPNMB BC069776 RNF135GPR124 PSMB6 LSM8GPR125 MFAP3 WAPLGPR155 GPN3 ARL16GPR34 RPL7L1 ITGA4GPR37L1 SMIM4 VWA2GPR61 LCN10 HPS5GPR63 MIR4657 /// PURBMXRA5GPR68 PSMD1 ARHGEF10GPR84 PI4K2A TMEM169GPR85 UBE2T LMCD1GPR98 ATP5G3 ZNF341GPRC5B RAPGEF3 CCDC28BGPX4 HRK KCNG3GPX7 MGEA5 SSBP4GRAP ESYT1 HECTD3GRAPL PRDM4 SSTR2GRASP ATIC AP1M2GRB14 FTH1 POLEGRHL2 RECK LIMD1GRHPR ANKRD20A1 /// ANKRD20A11P /// ANKRD20A2 /// ANKRD20A3 /// ANKRD20A4 /// ANKRD20A5P /// ANKRD20A9P /// LOC102723891 /// LOC102725051CPEB4GRID1 EBNA1BP2 /// MIR6733ZNF584GRIK4 ALDH1A1 THTPAGRK4 NDUFS3 /// PTPMT1LINC00869GRM2 BMS1P17 /// BMS1P18CPNE2GRM3 NCAPG2 QPRTGS1-124K5.4ADAMTS17PCNPGS1-166A23.2GTF2B PLEKHG5

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GSDMB ARCN1 KIF5AGSDMC TIMM10 LDB2GSDMD ATP6V1E1 CDC37GSG1 MCUR1 TLN1GSTA1 MAK16 RCHY1GSTA2 MKRN2 FOXJ3GSTA4 PTTG1 MDGA1GSTM1 RAD51C CTR9GSTM2 MRPL51 /// SPTLC1NIPSNAP3BGSTM3 C21orf59 ESYT2GSTM4 ACVR2B ITGA5GSTM5 SLC25A33 DDX31GSTO2 LZIC ESM1GSTP1 POLR2K LONP2GSTT1 FANCM MIS18BP1GTDC2 CWC15 SCML4GTF2H5 PPP4R1L /// PPP4R1LARVCFGTF3A TUBA1C USP46-AS1GTPBP2 ENPP3 ELOCGUCA1A TPH1 RARA-AS1GUCA2B CCT5 VAV2GUF1 RBBP8 DENND4AGULP1 PSMG1 ACTR3CGUSB TRAPPC2L BCAR3GYS1 LINC00328 BHLHA15GZMH NDUFAB1 LAYNH2AFY KLC1 DAB1H2AFY2 LOC102723927RAC2H6PD SCCPDH BRICD5HACL1 TRNP1 A1BGHADH NBPF10 /// NBPF12 /// NBPF14 /// NBPF15 /// NBPF20 /// NBPF8 /// NBPF9RPGRHAGHL E2F3 SVOPHAPLN3 NPIPA1 /// NPIPA5 /// NPIPB15 /// NPIPB3 /// NPIPB6 /// PDXDC2PMGAT3HAS1 CENPN PCNX4HAUS4 LOC340090ANXA4HCFC1 MCHR1 ECSCRHCFC1R1 RTCB DTNBHCK ZCCHC17 TRPC4APHCN4 NANP ZNF30HCST VARS2 ZNF322HDAC11 ZNF770 EIF5AHDAC5 LOC102724985 /// PDXDC1 /// PDXDC2PMAGI3HDDC2 ARL2BP DNMT3BHDDC3 DNTTIP2 PKD1P6-NPIPP1HDGF FUT11 TMEM14CHDLBP UCHL3 CHPF2HEBP1 NBPF10 /// NBPF11 /// NBPF8FAM76AHECTD3 ACVR1B PPTC7HELLS IRGQ CLCN2HELZ2 TXNDC11 LOC100507071

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HENMT1 C10orf10 GRM1HEPACAM2CCNH PCDH17HERC2 DBP SCN3BHEXB TSN CACNA1BHEXIM2 PON1 ALDH5A1HEY2 LOC100506076 /// LOC100506123B3GAT3HEYL DENR F11HIATL1 PPIH PLEKHM1P1HIBADH PTGR1 DOCK1HIBCH ATP6V1A TPT1HIC1 PHACTR1 MCUHINT2 CCDC136 TRIM13HIRIP3 REXO2 UHRF1BP1LHIST1H2BJ DDIT3 LPIN2HIST2H2AA3VTI1B ANGPTL4HIST2H2AA4NDUFAF2 MORC2HIST2H2ACTMEM135 ADAMTS6HIST2H2BEZNF823 CERKHIST2H3A LINC00493 CHCHD2HIST2H3C PCDH10 EIF3KHIST2H4A TMEM181 CUL2HIST2H4B LOC100132207POLR2DHJURP NTN1 SH3BP5LHK1 ABCD2 SPATA20HK2 PRDX1 FLJ42627HLA-A TUBB3 SLC17A7HLA-B CCNB1 LBHHLA-C IGK /// IGKCTRMT11HLA-DMA SYNJ2BP /// SYNJ2BP-COX16MMADHCHLA-DOB PSMD8 ERMP1HLA-DPA1 EXOC8 SERTAD4HLA-DPB1 CLEC4F KCTD12HLA-DQA1 NMNAT1 ADAMTS12HLA-DQA2 FAM20B RAB4BHLA-DQB1 SENP7 TTLL6HLA-DQB2 SSBP1 CSRNP3HLA-DRA PSMC3 NDUFA10HLA-DRB1 ICT1 MARVELD2HLA-E COX6B1 ARHGEF7HLA-F BLVRA MSX1HLA-G PSMA5 TTC33HLTF USP49 XPO6HM13 DYRK2 GSPT1HMBS CTCF CHGAHMGA1 RAB5C SPRYD4HMGB3 SVIP SLC38A2HMGCS2 PSME1 SPNS1HNF1B MKKS GRNHNRNPLL DYRK3 PHAXHOMER2 PROC PDCD11

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HOMER3 N4BP2L1 ADCY6HOPX G6PD REG1AHPDL SMIM12 LINC00665HPS3 FAM19A4 COMMD2HRASLS SUMF2 ATICHRSP12 ENO1 ZNHIT3HS3ST1 MIR101-1 /// MIR3671ATG12HS3ST3B1 SRRM2 ANKRD37HS6ST1 PTRH2 SYNGR4HSD11B1 NEU1 FXR1HSD17B14 FBXO45 SP2HSD17B2 KIAA0391 /// PSMA6NLNHSD17B4 MRPL15 SGK2HSD17B8 CAPS SCXHSD3B2 PSMA7 HDHD2HSDL1 TP53INP2 ADNP2HSDL2 SEC16B NRF1HSF2 MTUS2-AS1HOXB2HSPB1 EIF2S2 UBXN4HSPB6 ZNF189 MBNL1-AS1HSPB7 TUBB2A PCDHGA5HSPB9 MKNK1 ULK4HSPE1 CHKB-CPT1B /// CPT1BTXLNAHTR1F MB21D2 GNG11HTR2B ATP6V1B2 IRF8HTR3A MRPL36 GAL3ST4HTR7 ID1 MOB1BHUNK NPM3 FGFR1OP2HYAL2 NPIPA5 /// NPIPB3 /// NPIPB6 /// NPIPB8MED31HYKK AC004538.3 /// BC040327RGCCHYLS1 GREM1 CNKSR3ICAM1 FLJ11292 ECSITICAM3 LOC101928669 /// LOC644450MTCH2ICAM4 NUS1 CRTC3ICAM5 RTFDC1 NSD3ICMT MRPL21 TNK1ICOSLG DNAJC8 INPPL1ID4 TIMM8A IQCKIDH1 ANKRD53 BTBD7IDH3B CELF5 HSBP1L1IDO1 LOC399491UBE2FIDO2 OSGIN2 KCNAB3IER2 RP11-490G2.2GLCCI1IER3 CACYBP AGTR1IER5 HSPE1 MRVI1IFFO1 SAGE1 SMPDL3BIFFO2 PDCD5 PMP22IFI16 GRM1 MPHOSPH6IFI27 PBXIP1 ACOXLIFI30 NDUFAF4 RBM26

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IFI35 MZT1 OAS2IFI44 UQCR10 ATRNL1IFI44L PPM1N TRIM50IFI6 FAM162A CCDC61IFIH1 TMEM65 TUBBP5IFIT1 C14orf37 PNMA8BIFIT1B MRPL13 ARRB1IFIT2 IGKC XPO5IFIT3 ACTRT3 KLF16IFIT5 PLGLB1 /// PLGLB2DNAJC24IFITM1 SNRPD1 ANKRD65IFITM10 CENPW BUB1BIFNGR2 IQGAP1 UBE2D3IFNLR1 TECPR1 SUSD2IFT172 RNASEH1 TNFAIP8L1IFT20 TUBB TJP1IGFBPL1 GLO1 INAFM1IGFLR1 SNRPB2 CUTAIGLL1 LINC00475 CSNK1G2IGSF11 SMAD7 ALKBH1IGSF23 TFRC HDGFL3IGSF9B TUBB4B DNAJC22IKBKE TMEM242 ZXDBIL11 HAT1 SCOCIL12A PANX1 LRRC73IL12RB1 LINC00621 ERP27IL15 CLDN12 RPA2IL15RA DBH-AS1 ZFHX2IL16 AP1AR DCHS1IL17C PARS2 AP5M1IL17D COX17 /// POPDC2ZNF460IL17RD PSMC4 SH3PXD2AIL17RE FLJ38379 CCDC28AIL18 LOC692247L3MBTL3IL18BP HSPBAP1 SNHG32IL19 RFC5 IRF2BP1IL1A ENOX2 COPS7AIL1B KCNN3 HNRNPUL2IL1RN SNRPD3 FCSKIL20RA HLA-DPB2 ABRAXAS2IL21R SEC23B FEZ2IL23A LOC101928519VAT1LIL27RA TUBG1 GTF3C6IL2RA LOC101927359FBXO2IL2RG MTMR9LP NGDNIL32 POU6F2 IL17RCIL33 MIR133A1HGCBLCIL36G GOLGA6L4 /// GOLGA6L5P /// GOLGA6L9 /// LOC102724093EIF3AIL36RN LSM2 LOC729970IL4I1 COL27A1 KCNK9

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IL5RA EGFEM1P PRMT9IL6 PTPN11 PSMB8IL7 NDUFB3 REM2IL8 ADSL MORF4L1IMPA1 RAB21 CMKLR1IMPDH1 ZNF259P1 /// ZPR1GSN-AS1IMPDH2 SF3B5 SPTLC1INA FRAS1 LINC01521INCA1 CYCS SUMF2ING1 EXOC6 IKZF2ING2 RFC4 DYSFINHBC FLJ33534 TRMT13INPP5A DYNLT3 PAK5INPP5F RP11-182L21.5YES1INPP5J COX7B ZNF135INSM2 ZNF106 PRR19INSRR DERA SPEGINTS10 CKB MDFICIP6K3 PGD THRAP3IQCC AGBL2 SUMO2IQCH-AS1 BZW1 CCNIIQGAP2 UMPS ZNF117IQSEC3 HEXIM1 TBX2IRAK2 DCAF13 RTN1IRF1 ISG20L2 PRXL2AIRF2 WDR3 SNX6IRF2BP2 CHP1 GRPEL1IRF2BPL LOC101929760SNTA1IRF7 RABIF TMEM14BIRF8 BTF3P12 /// BTF3P12LOC101927245IRF9 RTN4IP1 GBP4IRG1 ANP32E NKAPD1ISG15 CDV3 TTLL3ISG20 SNX12 RALBP1ISLR MRPL45 MTMR10ISLR2 GEMIN6 PCGF1ISOC1 POLR2G SF3B4ITGA11 XRCC6 GMPPAITGA3 DNAJC9-AS1BOKITGB1BP1 OPHN1 NFXL1ITGB5 RP13-20L14.1LOC100506142ITGBL1 SMAP1 PCED1BITIH6 MRPL27 CLIC2ITPKC IGF2 /// INS-IGF2LOC728743ITSN1 SOCS5 TM7SF2IZUMO4 CAB39 ZBTB10JAG1 DPH3 RPUSD2JAG2 HRK /// LOC283454CRADDJAK2 CISD1 ZNF582JAK3 LOC101927830 /// TMLHE-AS1SLC17A6

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JAKMIP3 PRDX6 LETM2JPH4 ADK PLEKHA7JUN TALDO1 PROZJUNB TCTEX1D1 LOC102724908KANK4 MIR631 /// NEIL1TMEM108KARS PHYKPL RC3H2KAT2A ZNF585A TSPY26PKAT2B TDRD6 PI4KBKAT8 COX6C LOC100133091KATNA1 MIR6845 /// NRBP2ZNF761KATNAL1 ENY2 AMER1KB-1183D5.14ATP2C2 DHRS3KB-1592A4.14PVRL3 MSR1KBTBD11 ANXA2 /// NHP2L1PSENENKCNA5 DDX21 SLC7A6OSKCNE2 LOC101926951 /// PCDH20ADAMTS4KCNG3 GLB1L3 JAGN1KCNH2 FASTKD2 FMN2KCNH3 NRG1-IT1 MED20KCNJ11 NDC1 CMTM6KCNJ16 EMC7 CISD3KCNJ4 PPA1 LINGO1KCNJ5 SNRPE SGPP2KCNJ9 LINC01004 RBPMSKCNK16 MYH14 UBE3DKCNMA1 FAM98B ALMS1P1KCNU1 NME1 LOC100287808KCTD14 TACO1 LMAN2LKDELC1 PPIL2 MFAP2KDELR1 ATG16L2 U2AF1L5KDM6B HSPA4 VIL1KEAP1 TTI1 P2RY6KHK NOP9 UBE2Q2P2KIAA0040 HNRNPH1 JMJD1C-AS1KIAA0100 SSSCA1 POC5KIAA0196 RPP38 LIPGKIAA0247 BIVM SLC15A2KIAA0319 AX747135 /// RP11-863K10.7TTC7AKIAA1143 TCP11L1 LOC101927752KIAA1217 KCTD5 NFE2L2KIAA1239 PSMD12 CGGBP1KIAA1257 CDIPT SRSF1KIAA1324 MYCN ZNF268KIAA1429 SCOC ACACBKIAA1462 C19orf53 SULT2B1KIAA1614 POLA2 CCDC106KIF12 CYP39A1 KCNJ6KIF20B BLVRB LSP1KIF23 LGALS3BP PPP1R3DKIF26A LOC101929777 /// WNT3LINC00674

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KIFC2 MRPS28 UBE3AKIFC3 GUSBP11 ISG20KITLG PGAM1 TET1KLF15 PSMD14 KCNJ8KLF4 DUSP16 TMTC4KLHDC3 BTBD19 BEST3KLHDC7B RP11-278J20.2C2CD4AKLHL23 PAK1IP1 UNC5CLKLHL30 AK6 DDX10KLHL38 IARS2 PALMKLHL4 KCNIP2 RARGKLHL7 MRPL30 NDUFV3KLK4 NUMBL FAR2P2KLLN TERF2 LDHBKLRG1 SLC25A4 KCNK17KNOP1 RGS16 GNB1LKRCC1 PRRT2 DIPK1BKRT1 BRWD1 ZBTB9KRT18 ARGLU1 C12orf10KRT40 SAP18 ECPASKRT6A COLCA1 TOX2KRT6B MRPL42 C4orf3KRT6C HNRNPF ANAPC1KRT8 PTP4A2 ITGB8KRT80 THBS3 RPP25LKRTAP1-1 MRPS18B FARP1KRTAP2-3 INSM2 LOC100506258KRTAP2-4 ZNF354C SERPINE2KSR2 CCT6P1 /// CCT6P3CRYBA2KY WDPCP MISPKYNU DAD1 SULT1A1L3HYPDH AF520793 ARL6L3MBTL4 PSMB2 RASL11ALA16c-444G7.2UTF1 WNT9ALACC1 TMEM261 KPNA4LACTB POMP SLC7A2LACTB2 EXPH5 ZNRF1LAMA4 PDRG1 LINC01099LAMB1 ARL1 LINC02159LAMB3 NSUN5P1 /// NSUN5P2CRYBB2P1LAMC2 NDUFS6 SOWAHCLAMP3 ANKRD20A11PZBED5-AS1LAMP5 ABCD4 IQCDLAMTOR1 PPP1R3D LOC644285LAMTOR4 UBE3A P2RY1LAP3 RPAP3 DONSONLBH RNF115 ROR2LCE3D CREBRF ABCD1LDHB TMEM41A NEIL2LDLR KIZ CSDE1

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LDLRAD1 NBPF10 /// NBPF11 /// NBPF12 /// NBPF14 /// NBPF15 /// NBPF20 /// NBPF8 /// NBPF9LAS1LLDLRAP1 EMG1 PCDHGA3LECT1 PRKAG2 FPR3LEO1 AC005306.3IP6K1LEPREL2 PHIP SPTLC2LEPREL4 ZCRB1 H2AFZLFNG FRG1 /// LOC100289097 /// LOC101930278 /// LOC101930531STK32ALGALS14 MPV17L2 ZNF576LGALS4 TTC9C E2F5LGMN CLDN7 GYS1LGR5 EIF3M GPR27LIAS GTF2E1 MAP2K7LIF MIPEP BCL11ALIFR MREG PLD6LILRB4 PRKAB2 CD248LIMD2 TMEM185BPCDHGB7LIMK2 RASGEF1A RMDN1LIN7B NAA50 SYNJ2LIN9 PPFIBP1 TCHHLINC00205CLEC18A /// CLEC18CYWHAQLINC00261LINC01089 LGALS9LINC00315 SS18L2 MZF1-AS1LINC00478 SLC33A1 POT1LINC00595 TXNDC9 CDK5RAP2LINC00605 SHFM1 PCK2LINC00641 CRIP3 PCDHB15LINC00662 SV2B ZNF581LINC00677 SAFB CANXLINC00683LOC100506325PJA2LINC00704TMEM183A /// TMEM183BZNF583LINC00849 CKS2 SH3RF3LINC00857 SARS CSNK2A3LINC00880 NDUFA6 PCDHB7LINC00882 NAIF1 TLE6LINC00883ACTG1P4 /// AMY2B /// RNPC3SYNGR1LINC00930 ZNF689 TMEM170ALINC00948 ATF4 HPGDLINC00958 BUD31 BTG2LIPG AIFM3 TMEM43LIPH ANKZF1 WDR53LIPM RP11-469M7.1WDFY2LITAF TWISTNB ACADSLIX1L SNORA29 /// TCP1NDE1LMAN2L NGDN MYCT1LMLN STX8 LOC100499489LMO2 KPNA1 STON2LMO7 SLC2A2 ZFHX3LNPEP FAM166A ETV3LOH12CR2 MSANTD2 ARHGAP18LPAR1 EXOC5 EML5

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LPAR2 ALK LINC00641LPAR3 TAGLN2 RUNX3LPGAT1 CHAC2 PRPS1LPHN1 LINC00537 IGSF11LPO SLC35B4 OGFOD2LPPR1 VTI1A ANAPC13LRCOL1 UFD1L SLC39A8LRFN1 RRAGA HSPH1LRFN4 KIAA1211L ENDOVLRP10 UQCRFS1 LRRC59LRP11 TXNDC17 TTC39ALRP1B RAD51-AS1CKMT1ALRP3 LINC00184 AASSLRPPRC GNG7 PCDHGB1LRRC17 CNP TNFSF10LRRC20 USP4 TDGLRRC26 DPH1 /// OVCA2MTURNLRRC32 MRPS16 AP1G2LRRC34 MUM1 KLHL24LRRC36 NSA2 CRBNLRRC39 WDYHV1 CORO1ALRRC8D NDUFAF1 PATL1LRRN1 HBS1L CLIC6LRRN4CL EXOSC9 URODLSM2 RP11-124L9.5PSMC3LSMEM2 RP11-324L17.1DNAJC21LSR GLB1L2 HEY1LTA CLIC1 KCTD1LTBP1 AGMAT SLC35D3LTBP2 ELF2 GADD45GLUCAT1 TARBP1 USP51LURAP1L ANKRD18AMTG2LY6E TXNRD1 ZFP69BLY6G5C FAM179A SLC36A1LY86 STL KIF13ALYN ARID5A PPIDLYPD3 AK6 /// TAF9CALB1LYPD5 LOC101930075 /// LOC102724993 /// NPIPA1 /// NPIPA2 /// NPIPA3 /// NPIPA5 /// NPIPA7 /// NPIPA8 /// PKD1P1STRADALYSMD4 MRPL22 PDE1BLYVE1 NBPF1 GAS2MAB21L1 NHP2P2 /// NHP2P2SLC12A7MACC1 MIR6834 /// PFDN6GRAMD4MAFA XRCC5 ACOT11MAFF AC005606.14NANPMAFK LOC441124ZNF696MAGED1 USP14 CHST10MAGED4B VBP1 WWC1MAGEE1 DYNLT1 CBLL1MAGEH1 C7orf63 VSTM4MAGT1 NTN5 ZNF484

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MAMDC2 LOC101926967HBS1LMAML2 MAGED4 /// MAGED4B /// SNORA11D /// SNORA11EMYO6MAN1A2 LMBR1L KRTAP5-AS1MANBA CCDC180 /// LOC100499484-C9ORF174IGFBPL1MANSC1 MED11 IGF2-ASMAOA LOC101930075 /// NPIPA1 /// NPIPA2 /// NPIPA3 /// NPIPA5 /// NPIPA7 /// NPIPA8 /// PKD1P1THAP5MAP1LC3AC2orf82 MMP25-AS1MAP2K3 EIF6 PI4K2BMAP3K12 MRPL23 ASPHMAP3K15 AC073321.4TOM1MAP3K8 ESM1 ZNF503-AS2MAP4K2 LOC102724483 /// PIGLPREX2MAPT SEC23IP MICAL3MARC1 OXNAD1 ARMC1MARC2 AQP6 IFITM2MARCKS EIF3I PTPRGMARVELD1OAZ3 NXNMASP1 CEP72 CPMAST1 CXorf21 CACNA1DMAST4 METTL3 RFC1MAT2B PNISR ADGRA1MATK CCNL2 ERV3-1MATN2 DSTN MAPK6MATN3 SNORA72 ETNK2MB CPXM2 FCF1P2MB21D1 MON1B WDR20MBD6 ATP5C1 LAIR1MBOAT2 STAT4 BPNT1MCCC1 SIPA1L2 GTF2A1MCF2L2 TMEM91 C12orf65MCL1 VPS25 CADM4MCM6 TRAPPC2 /// TRAPPC2P1OXSR1MCOLN3 AGAP11 CD99MCTS1 IDI2 RABAC1MDFI MCM9 OR7E14PMDGA1 ZNF692 PPP2R1AME3 NDUFB4 CSRP2MEAF6 PRSS50 RABGAP1LMECR UBB SCFD1MEF2C LOC645513CLMNMEGF11 RPL24 MSH6MEGF6 NSUN5P1 GLI2MERTK MAMDC4 RAB37MESDC1 THADA SNX19MESP1 COMT PCBP4MEST LLPH PIN1METRN LINC01341 RNF8METTL10 HIGD1A ITSN1METTL17 EPHA7 TP53I11METTL20 MCM2 ZFP91

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METTL7A NCOA4 APBA1METTL7B ADAM8 CBFBMEX3A APOOL PGFMFAP2 SELK ZNF506MFF CH25H ATL1MFNG RASEF METTL22MFSD2A C3orf62 /// MIR4271TDRD6MFSD3 PLXNB3 ITIH5MFSD6L AK094644 HACL1MGAT2 KIAA1524 ANTXR1MGAT5B PCBP1 PELI1MGC20647TUBA4A SPEF1MGMT EPHA5-AS1TRPV2MGP OGFOD1 KIF13BMGST1 RUSC1 SPATA13MICAL1 PCYT1A DNAJC19MICALL1 DNAI2 RIMKLAMICB ARPC4 /// ARPC4-TTLL3 /// TTLL3C12orf75MICU2 NUP155 TRRAPMIDN CHRNB1 TGS1MIER2 ENAH SELENOPMIF4GD RP3-329A5.8LRP5LMIR143HG SRPRB PRKCQ-AS1MIR146A IGH /// IGHA1 /// IGHA2MYO18AMIR155HG TOMM34 TCF7L1MIR24-2 NUDT5 ZNF43MIR4720 PDE4B FAM3AMLF1IP RAB9A GET1MLKL SUZ12 USF2MLST8 VWCE TOR1AIP2MLXIPL SLC18A2 CCR1MMAA CLDN23 ANKS6MMACHC RSAD2 PRADC1MMP1 GCOM1 /// MYZAP /// POLR2MTMEM126BMMP10 FEN1 POM121L9PMMP11 SLC24A2 INSM1MMP15 TXN STMN1MMP25 CST7 PANK1MMP3 EIF2S1 SSBP2MMRN1 CCDC51 GJD3MMS22L LOC100652930 /// NPEPL1 /// STX16-NPEPL1RBCK1MN1 ZMYND11 UBR2MNX1 ANKRD33 PEAR1MOB1A DDX5 /// MIR3064 /// MIR5047ANKRD17MOB3C RET ZNF543MOCS2 NUP88 DHRS12MOV10 LRRC23 /// RPL13P5TCP11L2MOXD1 ZMAT2 FRMD4BMPC1 MUC19 KLHL18MPG PABPN1 RNASEL

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MPP1 LINC00260 TPM1MPV17L THOC1 TRIM36MR1 ABCA6 LINC01933MRAP2 ECHDC2 SRGAP2MRGPRX3 ID4 LRATD1MRM1 TRIM52 DZANK1MROH7 LOC101929465HIST2H2BEMRPL12 IQSEC3 ZNF766MRPL14 EXOC7 AQRMRPL15 MRPL35 MYBL2MRPL24 RPL7AP71 /// RPL7AP71EXOC8MRPL34 CRIPAK ZNF141MRPL40 PRICKLE2 BCAMMRPL48 OSTM1 BRI3MRPS2 CNST MRPL58MRPS26 ABHD5 FSTL1MRPS27 ZFR2 SAMD9MRPS34 SHQ1 ANXA6MRPS7 CMIP /// LOC100129617POU2F2MS4A6A ORMDL2 SRP19MSRB1 DSCR3 CYTH3MSX2 SLBP FAM204AMT1E ZNF831 CORO7MT1F ASXL1 SMG7-AS1MT1M LCMT2 ING5MT1X ACCS SIX4MT2A IPO11 /// IPO11-LRRC70DCP1AMTA1 CHTF8 RTCAMTCP1 RWDD2B CEP97MTF1 METTL2A /// METTL2BPCDHGB2MTHFD1 TAF1A-AS1KIAA1755MTHFR RP3-406P24.1ZNF763MTIF3 LOC100507520ARNTLMUC15 STAU2 GFM2MUC16 NXT2 LINC01770MUC20 ECD CEBPZMUC4 RUVBL1 MYO1BMVB12B KCNH8 TMEM8AMX1 LOC101060179 /// PRDM11RSPRY1MX2 UBE2L3 SMAD5MXD1 AX747132 /// RP11-458D21.1 /// RP4-791M13.3C17orf113MXD3 MYL4 SNAI1MXRA7 LOC101928669 /// LOC101930100 /// LOC644450RASSF8-AS1MXRA8 TTC7B GSDMBMYCT1 MAPKAP1 ATP6V1G2MYD88 MAP3K4 RBM43MYEOV CHMP3 /// RNF103 /// RNF103-CHMP3CD276MYEOV2 DAP3 ALOX5APMYH6 SQSTM1 PCBP2MYH7 COA1 KAT7

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MYL6B DLAT EPN2MYL9 WSB2 INPP4BMYLK3 ACAT2 HTATIP2MYO1B GUSBP2 TMEM140MYO1G HEXDC OR7E47PMYOCD C5orf66 CCDC65MYOM1 TRIP4 PECRMZF1 CAP1 SRPX2MZT2B LTB4R STX7N4BP2L1 SCYL2 TBC1D8-AS1NAALADL2LL22NC03-N14H11.1TM9SF4NACA IKBKAP FBXL12NACC2 FGR C18orf21NAE1 CNTRL FAHNAGK STEAP3 POLHNAGS DMTF1 PPP6R2NAMPT RSL1D1 KIAA1324NAMPTL GSTZ1 TMEM231NANOS1 CSAD PHKA1NAP1L3 OLIG1 RPP38NAPA PLA1A CGNNAPEPLD DHDDS ABCB9NAPG EIF3H ABCA2NAT8L LAMTOR5 OPTNNAV1 KCNH3 H2AFJNBEAL2 RP11-710C12.1CCDC6NBN LOC101060604 /// SLC7A5P1 /// SLC7A5P2LONRF1NCCRP1 LUC7L SLC41A3NCF1 MTMR6 HNRNPDNCOA7 ARMC10 VCPIP1NDC80 BAI3 UBAC2-AS1NDFIP2 CCNY RRP8NDN HMOX2 DYNC2LI1NDST3 mir-223 MED19NDUFA10 ADAM23 IFT172NDUFA11 CUBN DGKBNDUFA12 OFD1 ARHGDIANDUFA3 TM2D2 NR1H2NDUFA9 LOC100506538GFERNDUFAF6 RP11-1007O24.2RASSF4NDUFAF7 CNIH4 ZNF789NDUFB1 LOC100506314DELE1NDUFB10 ZNF622 ST6GALNAC5NDUFB9 RAP1B ACER3NDUFC2 ALDOA C2orf68NDUFV1 AC128677.4 /// CH17-132F21.1 /// IGKV1OR-1 /// IGKV1OR-1 /// IGKV1OR10-1 /// IGKV1OR10-1 /// IGKV1OR2-2ZNRD1ASPNECAB2 SCD GLP1RNECAB3 TMEM132AC2orf16NEGR1 ARPC3 NAA10NENF KCNK1 CARHSP1

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NES SNRPC ISM1NEURL NDUFA7 EHD4NEUROD1 C2orf47 FGD6NEXN MYO5B TRAP1NF2 MRPS10 ZDHHC5NFAM1 PAFAH1B2 S1PR3NFATC2IP IFIT5 SERPINE1NFKB1 IGJ RTN4RNFKB2 RP5-1092A3.4GRK5NFKBIA LARP4 KCNJ16NFKBIB KCNQ2 ZNF32NFKBIZ ATP5G1 RNF208NFYB PRF1 PDE8BNGFRAP1 ARMC12 NINLNID2 NISCH GXYLT1NIM1 POLM RGS12NIN SYT1 PLCG2NINJ1 KCTD16 GMPR2NINL DDB2 FBXW5NIPAL2 WASL PDE4CNIPSNAP1 NOP10 RAB5BNIPSNAP3BNET1 MORN4NIT2 ARID4B /// RBM34ADRB2NKD2 CIB1 NDUFB1NKX2-2 LINC01346 MAPRE1NKX3-1 LOC440434GDPD1NLE1 MTDH NOL10NLRC5 C1orf168 RMND5ANLRP12 CHRNA1 TIMM50NME1-NME2CYS1 MTUS1NME3 PTCHD4 CLK3NME4 AK096592 /// YLPM1PABPC4NME6 PDE7B CUL4ANMI RNF113A LINC00473NMRK2 TTL MMS19NMT1 FKBPL BOLA2BNMT2 AK057657 /// RP11-473I1.9ZNF366NMUR1 CROCC NOB1NOD2 TMEM11 NT5C2NOS2 RP11-399E6.1C3orf67NOSTRIN ZNF697 ATP6V0D1NOVA2 MEFV ZNF589NPAS1 ABHD3 PLEKHO2NPBWR1 PIANP SNX17NPM1 RNF181 PSMD6NPM3 BMP2 PDZK1NPPB TCP11L2 TBCENPRL3 SIDT2 LMO2NPTXR LOC101928464MAGEE1NR5A2 ADH1B RAB26

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NRARP MAFG AAASNRGN ZSCAN31 TESK2NRIP2 APTR GSTA2NRK PSMA4 ZFP28NRP2 CTNNA1 LOC100049716NRSN1 AHSA2 ZDHHC24NRTN MTIF3 NID2NRXN2 GPATCH11 PPIAL4ANSA2 R3HDM1 CNN3NSG1 APMAP SLC25A28NSMCE1 AQP5 STAT5BNSMF TRIAP1 RASGRP1NT5C3A CCNC RGS7BPNT5DC2 EIF5A2 MPPE1NT5M JMJD7-PLA2G4B /// PLA2G4BMAN1A1NTAN1 TIA1 TSPAN11NTHL1 MRPL51 GTF2IP1NTRK2 HBB YPEL2NUAK2 CACNA2D3GRID2IPNUB1 ABCE1 ITGA8NUCB1 VTA1 C19orf44NUDT13 RALY PRKD2NUDT14 TPRKB ZNF561NUDT16L1 COIL MRPL35NUDT3 USP46 ROR1-AS1NUDT8 STX16 PFKPNUF2 MRPL48 DGUOKNUGGC GLRA1 LARP6NUP133 TTC21A GATAD1NUPR1 SETD4 LOC102725021NUPR1L DEF8 VSNL1NYAP2 TRO TUT4OARD1 AAR2 TAF8OAS1 MST1R EIF2B5OAS2 IGKV1-17 /// IGKV1-17KIRREL1OAS3 AX747630 ADCY2OASL GLRX2 THG1LOAZ3 NDUFA9 TMED6OBFC1 ANP32A KDM6AOCIAD2 GLTSCR1L CORO2AODAM RP3-476K8.3DPP9-AS1ODF3B ATP5S ZNF420ODF3L2 AOC2 STX8OGDHL PDE12 LIMK1OGFR BC048103 /// CSGALNACT1ELOVL6OGFRL1 SNRPA1 MAST4OLA1 SSB PDGFBOLFM2 SMIM15 GLYR1OLFML2B AGAP10 /// AGAP11 /// AGAP4 /// AGAP5 /// AGAP9 /// BMS1P5 /// CTGLF12P /// LOC101060581ORC5ONECUT2 STKLD1 SLC44A2

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OPALIN KSR1 LOC100288203OPHN1 FAM98A HYAL3OPTN TENM2 SLC35G1OR2A4 MFSD8 LOC441204OR2A7 RPF2 GINS2OR52N4 LOC100996724PLA2G7OR7E24 CPNE3 CDH11OSBPL1A GPR143 C19orf25OSER1-AS1EXTL3-AS1 TECPR2OSGEPL1 PSMC6 MST1LOSMR CTD-2012K14.6TMEM30AOTOA ILF2 MGAT4AOTUB2 SPRYD7 ADRA2AOVOL1 PODN KLHL29OXGR1 MTFP1 AP1ARP2RX3 FBXL5 PKNOX2P2RY8 STK36 TMPO-AS1P4HB MC1R ABT1P4HTM KIF5B DCAF11PAAF1 SET /// SETSIPZNF497PABPC4 TLL2 MYH14PACS2 SC5D PKD2PADI1 REL ISYNA1PADI2 C4orf46 CDC42EP3PADI3 AL022344.5PCDHGA11PAEP USH2A ZNF875PAFAH1B3 POLR2D PUF60PAIP2B NTMT1 SRPXPAK6 EARS2 HCFC1R1PALD1 TXNIP FAT3PALM3 IGFN1 CASC15PALMD CGA SLCO2B1PAM16 PARP6 KATNAL1PANK1 EVL RBPJPANX1 PDCD2L FZD5PAQR4 YRDC IER5LPAQR7 TTLL10 FAM222APAQR9 FAM214B AGGF1PARD3 OTUD6B-AS1MSANTD4PARD6A BEND3 GHDCPARP10 NDUFC1 FNIP2PARP12 TMEM150AFLNB-AS1PARP14 MRPS17 CCNDBP1PARP16 MMGT1 KIAA0753PARP2 BTNL9 ZNF81PARP3 ARHGEF37 SSRP1PARP9 POLR1E SMIM10L2BPATL1 FAM175B CCDC68PATL2 USP22 ZNF773PAX4 ID3 STK33

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PBX3 UBE2K CHST4PBXIP1 ADAM33 GSTM2PCBD1 CCNB1IP1 RNASET2PCBD2 KCNB1 NEK1PCBP3 PPM1M H19PCDH12 TP53RK SND1PCED1B TPI1 GABPB1-IT1PCMT1 BC024027 /// RP11-268G12.1GALNT10PCP4 UBE3C H2AFY2PCP4L1 WDR53 CEP170BPCSK9 ANXA2P3 E4F1PCYOX1L ETF1 CLDN5PCYT1A SMAD3 PARTICLPDCD1 KIAA0087 SFXN5PDCD1LG2RP11-332H18.4HPCAPDCD2 OSGIN1 MARF1PDCD4 TMEM223 CASP1PDE1A C12orf43 NHSL2PDE4C NAA40 USP6NLPDE7B MRPL54 BIN1PDF UBE2QL1 TOM1L1PDGFC NDUFA4 ZWINTPDGFD KLHL31 ZNF213PDGFRA RPL14 CSNK1EPDIA2 OXSR1 YEATS2-AS1PDIA3 FANCL C1QBPDIA4 MBD6 TMSB4XPDIA6 ANXA2P1 CYP39A1PDLIM2 LOC101928521ZNF487PDLIM3 RP11-533E19.7POLIPDPN CHCHD2 DCAF17PDSS2 SFPQ ENAHPDXK MFI2-AS1 LOC101928174PDZD3 KBTBD8 HMOX1PDZD7 PLRG1 PIGOPDZK1 QRICH2 CAMK2BPEBP1 IGLV1-44 F3PECR ANKRD36BB3GALT2PEG10 ITGAL CLSTN1PELP1 DANCR TM4SF18PEPD PFDN1 MFSD4BPFDN1 RBM8A THRAPFDN4 DLG5 LPP-AS2PFDN5 RPS6KA2 MDH2PFKFB2 LOC101927560 /// LOC101927587SNHG17PFKP FARP2 GAB2PFN2 MIR3658 /// UCK2ZNF337PGAM1 VAT1 SLC25A20PGAM4 ZNF813 BNIP1PGAP2 GNL2 SLMAP

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PGBD5 ANXA10 ZNF814PGK1 TPCN1 MIGA2PGM2 NPIPA1 SMAD6PGR FYTTD1 NOL4PGRMC1 RMST SLC9A3R1PHACTR3 INSIG2 RSU1PHB2 STRADB TOMM40LPHF11 TNFRSF12AMAPK10PHF15 ARHGEF25 DIDO1PHF2 CRLF1 SEMA3GPHF7 CSRP2BP /// PET117CCNA1PHGR1 CCDC85A MIS18APHLDA2 RNF34 LOC100130992PHLDA3 CCDC39 /// LOC101928882NUP153PHLDB3 CTB-43E15.1PBX3PHOX2A LINC01410 KANSL1LPHYH DCTN6 LMBRD2PI3 LOC339539FAM89BPID1 GALNT14 SLC43A2PIEZO2 CMPK2 RAB19PIGB LRRC6 SNCAIPPIGK RP4-539M6.21ZC3H11APIGP RGL3 AGAP1PIGR ARFIP1 SNRPCPIGZ SLC30A1 ITGB3PIK3AP1 NANOS3 HAX1PILRA AGPS SEC62PIM2 ASH2L ZNF707PIM3 RIPK4 VPS16PINK1 COX10 HPCAL1PIPOX CNTNAP5 FAUPITPNB MRTO4 SH3TC1PKD1L1 CEBPG ZBTB16PKDCC ASPH GJA4PKDREJ DAPK3 ADHFE1PKHD1 CCDC144A /// CCDC144B /// CCDC144CP /// LOC101929141BIN3PKMYT1 COPS3 SMOPKN1 TES RNF122PLA1A SCNN1B ARL15PLA2G15 CCDC24 NRP2PLA2G2D FGFR1OP RPAP3PLA2G4C PRDX5 WNK1PLA2G4D KIF2A HES6PLA2G4E GSTM3 SLC7A11PLAU GNA13 AP3B1PLAUR PABPC1L WTAPPLB1 SLC24A3 NWD1PLCD1 ZNF337 CMTM3PLCE1 METTL8 LETMD1PLCH1 HSPE1-MOB4 /// MOB4ELMOD2

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PLCL1 ARHGAP33ASS1PLCXD2 PRSS23 PFKFB2PLCXD3 PMFBP1 ZNF792PLD2 UBTD1 IGBP1PLD6 MUC12 STARD8PLEK IGLL3P NTNG2PLEKHB1 NACA CYP2T1PPLEKHD1 SFI1 CCDC74APLEKHG3 DRAP1 LOC100507599PLEKHJ1 CYB5R4 TNFSF12PLIN4 ZNF57 SNAI2PLLP DKK1 GAB1PLRG1 ABT1 CREBZFPLSCR1 MCAM /// MIR6756ALG1PLXDC1 AKIRIN1 SH2B3PLXDC2 ANKRD36 FMODPLXND1 PITPNM2 ANAPC10PMAIP1 SNED1 MOCOSPML PSMA2 THADAPMS1 PDE1A UQCRFS1PMVK DLEU7-AS1ZNF652PNKD ABCC5 SULT1B1PNLIPRP1 LARP7 C5orf30PNMA3 SKP2 C1orf122PNMA6A UBE2V2P3 /// UBE2V2P3PGPPNMA6B CCNK CFTRPNMA6C MICU1 FAM98BPNMAL2 STK35 FUT1PNPLA7 IGLC1 CASC3PNPT1 MIR3934 /// UQCC2PRPH2PNRC1 CALY ATP5F1CPODXL2 VRK2 MRLNPOLDIP2 HMHA1 MOB3CPOLR1C MRPS11 CIR1POLR1E LOC101928524 /// PRPF18COMMD4POLR2E PREP CDAN1POLR3H DFFB GREB1POLR3K TBC1D7 RPS6KA4POMP AZIN1 ASXL2POMT1 YTHDC1 ONECUT2POU2F2 TMEM189 /// TMEM189-UBE2V1 /// UBE2V1 /// UBE2V2UBQLN1POU3F1 ZNF829 CYS1PPA1 EML6 COL22A1PPA2 RBM47 TTI2PPAN TMA16 NIBAN1PPAP2B CDK9 FN3KRPPPAP2C LOC100128922SERPINB8PPARG TKT DDX59PPCDC MARVELD2PIP5K1CPPID APOD ECHDC2

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PPM1M AKR1B10 FKBP4PPP1R11 FLJ38717 PTGES2PPP1R14A AGAP11 /// AGAP4 /// AGAP6 /// AGAP7P /// CTGLF12P /// LOC101060581RNF224PPP1R16B RBM26 DPF1PPP1R18 HIST1H3C ID1PPP1R1B UBE2D4 NYAP2PPP1R1C RP4-539M6.14EDEM3PPP1R3F LINC00616 ARHGAP12PPP2R1B P2RY14 DDX11PPP2R3B LOC441081CCL28PPP2R5B ABTB1 PDCD4PRADC1 PSME3 GSTO2PRCP MIRLET7D LSM7PRDM8 TRIB3 R3HDM1PREX1 LINC00639 LOC100130111PRF1 KMT2A /// LOC101929115PFKFB3PRKAR1B TUBA1A FIZ1PRKCH BC062763 NOL11PRKD2 PPIA CHKBPRMT3 CORO6 NCOA5PRMT7 LOC728353KCNMA1PROC EXOC3 KLHL21PROM1 TTLL6 QTRT2PROM2 DDX49 ZNF777PRPSAP1 ABHD13 MAML2PRR15L DNAJC14 GPSM3PRR5-ARHGAP8SPRR3 ADAMTSL1PRRC2C PDSS2 SWAP70PRRG4 LOC101060363 /// PPIAMTMR1PRRT1 C11orf53 CD3EAPPRRT2 LOC101929718CYYR1PRRT4 PRMT2 CRELD1PRRX1 ANKRD50 RWDD3PRSS1 C11orf48 /// LOC102288414SCAF11PRSS23 TRIM36 WDR62PRSS3 CHN1 CISHPRSS46 RMND5B GPATCH2LPRTFDC1 BCL2L13 PABPC1PRTN3 MTMR2 THAP1PRX XRCC4 ENKD1PSD CTC-429P9.3CDKN3PSG3 LOC102723704PLEKHM2PSG5 SNRNP70 LOC100129434PSG8 RHPN1-AS1ALG9PSG9 LMO3 ZDHHC9PSMA2 BLOC1S3 C9orf40PSMA3 DUSP3 FAM124APSMA4 LAMB3 LPCAT4PSMA6 LOC284669LOC285074PSMB10 KCNV1 PGGT1B

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PSMB2 IFFO1 LRRFIP2PSMB8 CFD HARSPSMB9 KIZ /// PLK1S1SLC38A1PSMD11 TYW3 RAB3DPSMD12 ITGB2-AS1 FGD3PSME1 FRG1B RIOK3PSME2 HERC2P2 /// HERC2P9COPS6PSMG3 CUL1 RBM7PSTPIP2 SYNE1 BBS4PTAFR SPRTN PCDHGB5PTCH2 TNRC18 DAPPTDSS1 SLC30A5 FASTKD2PTF1A AP1G2 CD320PTGDR2 TYK2 A2MPTGER2 ALG10 FUT11PTGES CHML ZNF800PTGR1 IDUA EME2PTOV1 PPFIBP2 LOC101928303PTP4A2 KIF3B CSTF1PTPDC1 AGFG1 LINC02615PTPN1 METTL21A FKBP11PTPRU GNAI3 HDAC3PTRHD1 VDAC2 BBS7PVRL2 AP1G2 /// JPH4CRISPLD2PVT1 SNX31 STAP2PWWP2B DYNC2LI1 SCRT1PXMP2 FECH PREPLPXMP4 CTSF ATAD1PYCR1 PKN1 EBF1PYDC1 UBE2V2 FAM86DPQDPR BLMH PRORPQPRT TRIB1 IGSF10R3HDM4 MPV17 TOE1RAB11FIP3 C4orf19 SNRK-AS1RAB17 MOB4 DHX33RAB19 APOLD1 PDGFDRAB20 PLB1 CH17-340M24.3RAB22A FZD1 LOC100129617RAB24 LOC100507006PCOLCERAB2B TRABD CNTN4RAB33A GAR1 PLA2G15RAB37 ASAH2B ZNF516RAB3A AX746710 MPLRAB3IL1 KLHDC4 /// LOC100129637CNOT6RAB4A NENF IFITM3RAC3 LOC100287166 /// LOC101930064PARP11RAD21L1 BC040624 /// FOXP1-AS1 /// FOXP1-AS1LINC00643RAD51C FCRL2 PIGGRAI1 GFER MTMR11RALB SMEK2 PPP2R1B

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RALGAPA1RP11-196G18.24PANX2RALYL TMEM212 SNF8RAMP1 ARPC5 LINC01091RAMP2 SLC11A1 RCE1RAMP2-AS1PDP1 CFAP43RANBP1 C19orf33 ZNF93RANGAP1 C3orf52 MEIS3P1RANGRF CALCA CSGALNACT1RAP1GAP AGAP6 NLGN1RARRES1 HMGN3 GPR162RARRES3 EBP EIF2AK3-DTRARS LOC388692RAB2BRASD1 RGS11 AK3RASD2 MYL6 ACSS1RASGEF1A PCED1A SDHDRASGRF1 PEX2 PTK2BRASIP1 DNAJC12 CCDC90BRASL10B LOC100506124 /// TTC21BRPS6KA5RASL11A RAB11FIP5 SLC45A4RASL11B PHACTR3 SNRNP200RASL12 KRT18 STARD3NLRASSF9 PLEK2 IFT81RAX YARS2 IDH3BRBBP8 SPSB3 VMACRBBP8NL YWHAG CCNB1IP1RBCK1 ZNF681 BCO2RBFA C1orf43 CADRBM20 DOHH CCT6P1RBM38 MYL12A /// MYL12BENY2RBP1 BTF3 ACOT4RBPMS2 UTP3 PSPC1RCAN3 SNX21 LINC00680RCBTB2 SDC4 CXCL12RCN1 RP11-846E15.4ZNF658RCN2 LOC100288974 /// MBL1PPGM1RCOR2 CABIN1 TMEM196RDH10 AGAP4 IPO11RDH12 SCAMP3 TSC1REEP2 GSTM1 SMC1AREEP6 CYAT1 /// IGLC1 /// IGLV1-44BROXREG1A KLHL15 AGTPBP1REG1B PXMP4 EDNRAREG3G COX7A2P2 /// COX7A2P2SAMD13RELA CHAF1A LOC105372633RELB PLXND1 FRAS1RELL1 RP11-319G9.3AS3MTREPS2 UNC5C ZNF134RERG RBP7 CA8RETSAT ZNF616 CCDC3RFC3 VAV2 NDC1

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RFC4 FUCA2 PHF23RFFL LOC574538EIF4G1RFTN2 MLF1 SAMD4BRFX5 ZNF251 LOC100129534RGL2 NAA15 ZNF736RGL3 RANBP6 FAM86C1RGMA MBNL1-AS1DMGDHRGS16 NDUFA12 ANPEPRGS9BP LOC100506497RFESDRHBDF2 LOC102725017TBX6RHBDL1 PSMB4 LOC101929532RHCG CWC27 LRRC9RHEBL1 SLC25A5 EIF3DRHOBTB2 NIFK TRPM6RHOD CDK7 ERCC2RIMBP3 SF3B6 ANKMY2RIMBP3B EIF4B NAV2RIMBP3C POLR3D TRAPPC4RIMKLB STAB1 IPO7RINL CABLES1 RANBP9RIPK1 LOC102724094GPR158-AS1RIPK2 FAM208A MDKRIPK3 RNF6 PARP6RIPPLY2 KRT7 CITRLN2 FAM95B1 /// LOC101928261 /// LOC102724314NPTX2RMI1 RPL36A /// RPL36A-HNRNPH2LGI2RMI2 RNASET2 MRPS25RND1 AIFM2 PAPPA-AS1RND2 ZNF627 ANO1RND3 MYO15A CACNG4RNF114 LINC00930 RNF215RNF130 PIK3CB EXT2RNF144B GUSB COLCA2RNF148 RAB31 CLASRPRNF149 PIGL CCNI2RNF157 SEPT11 FAAP24RNF182 LINC01214 CTNND2RNF186 FAM32A EHMT2RNF19B IGF2BP2 ZNF764RNF2 IFT80 GATD3BRNF208 MRPS7 TPM1-ASRNF213 ASNSD1 ZNF519RNF214 COMMD2 CFIRNF220 TFF1 ZNF365RNF24 DNAJB11 ZNF33ARNF8 TMF1 CRLF1RNFT1 GPR176 RRN3P1RNH1 TMEM203 PLPP6RNLS MIR4800 /// MXD4OTULINRNPEP RP11-539L10.3PTPDC1

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ROBO2 LOC100128554LPIN3ROGDI LOC101928327LUMROM1 STS ADAM33RORC NUFIP1 PATZ1RP1-140K8.5SOX1 LOC257396RP1-193H18.2FADD ADAMTS14RP1-212P9.2IGKV1OR2-108 /// IGKV1OR2-108TMED7RP1-224A6.3GATA6-AS1MOCS2RP1-278O22.1AGPAT2 CLEC2BRP1-60O19.1DSCAM-AS1FAM110ARP11-1002K11.1BRI3 SEC14L2RP11-1055B8.3MRPS12 HLA-DRB1RP11-109D9.4KRT8 ZC3H7BRP11-111M22.3TRMT12 CD53RP11-112L6.4POR SLC3A1RP11-1136L8.1ATG5 HRRP11-113K21.4LMO1 SHLD3RP11-11N9.4BRD7 GMFGRP11-121C2.2TTBK1 PAXIP1-AS2RP11-122K13.14SLMO2 ZFYVE21RP11-1348G14.4C21orf15 ZCCHC9RP11-134N1.2DOLK RBP5RP11-137H2.6FIGN ADARP11-13B9.5LOC100506469PRCPRP11-13N13.2GOLGA2P5ACOT13RP11-1406H17.1ACTA2 /// ACTA2DVL1RP11-140M13.1SF3B1 GRID1RP11-143K11.1C6orf58 TAF9RP11-157E21.1GPN2 LINC01050RP11-162G9.1MRAP2 MTMR14RP11-16E12.1COX17 TYROBPRP11-184M15.1NIPAL2 LOC101409256RP11-204M4.2ARSG EHD1RP11-206L10.9PIGM GDAP1L1RP11-211G3.2TSR3 LINC00870RP11-211N8.2MAATS1 SOCS1RP11-213H15.1NECAB2 MRPL33RP11-214N9.1AK4 /// LOC100507855GATD3ARP11-223C24.1NEDD8 PAK3RP11-258C19.7ALAS1 FAM214BRP11-259O2.3CCNT2 SLC25A5-AS1RP11-25J23.3GPR153 SNRPB2RP11-276E17.2GRIA1 SNRPA1RP11-277L2.3USP39 ADSLRP11-277L2.4HEBP2 TRA2ARP11-279F6.1TTC14 DLL1RP11-27N21.3FKBP1A-SDCBP2 /// SDCBP2SHERP11-284F21.9ACADVL DDOSTRP11-285A1.1COG8 /// PDFCTNNBIP1RP11-288G11.3MCCC2 PRUNE2

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RP11-288L9.1SIN3B SPARCRP11-292F9.1TACR1 HHLA3RP11-297M9.2EBF4 NUDCD3RP11-2E11.5C8orf59 TANC1RP11-2L8.1TAC1 PPARGC1ARP11-31E13.2COL28A1 HLA-ARP11-320M2.1DSTNP1 /// DSTNP1PLAAT4RP11-320P7.2RAB1A BCCIPRP11-322E11.5TRAPPC1 TMEM160RP11-326I11.3DHX36 METRNRP11-327I22.8PTCHD1 MTFP1RP11-337C18.8STARD7 SLC8A2RP11-340I6.8AP1S3 SMIM26RP11-344B5.2LINC01355 ABHD11RP11-345M22.2MCTS1 HS3ST2RP11-346C20.4CTB-78F1.1GPR146RP11-353N4.4LOC100133130SERPINA6RP11-367F23.2ARHGEF7 CFAP221RP11-375B1.3POMT1 LEPROTRP11-37B2.1NKAP FHL3RP11-383C5.3THEMIS2 OLFM4RP11-383C5.4BBIP1 /// LOC100130175SNHG10RP11-384P7.7OSTC MED28RP11-38P22.2APOL4 VAMP7RP11-390F4.6ME1 LRRN2RP11-391M1.4RPP30 B3GNT9RP11-394I13.1RBM45 PPP4R1RP11-3P17.4NUDCD1 BIRC6RP11-403I13.8PRMT6 IDERP11-407B7.1LINC00511 /// LINC00673CROCCP3RP11-408H1.3OTOGL MXRA8RP11-410L14.2PSMD11 CARD10RP11-419C23.1WDR27 LOC400940RP11-426C22.4CHCHD1 SH3RF1RP11-42I10.1GLB1L TP53I3RP11-430C7.5LOC101929114SUMO3RP11-439L18.1LRRN4CL ZNF737RP11-43F13.4BID TENT4ARP11-449D8.1AP000462.1GPBP1L1RP11-44F14.2CYB5R2 TAF5LRP11-44N21.1GSTM2 MIR1915HGRP11-457M11.5TNFAIP8L3 TRMT9BRP11-459C13.1ZNF576 DNAJB7RP11-462L8.1FKSG49 PDPRRP11-463O12.3ZNF638 /// ZNF638-IT1EPS8L2RP11-468H14.2PLGRKT DPY19L3RP11-473M20.16KXD1 TUBGCP6RP11-475I24.3FRMD4A ATP8A1RP11-490M8.1CENPQ CACNA2D1RP11-491F9.5RAD52 ZNF559-ZNF177

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RP11-497E19.1GCHFR IQCERP11-498P14.5SLC12A5 PCDHB8RP11-502I4.3IPW /// LOC101930404 /// PWARSN /// SNORD107 /// SNORD115-13 /// SNORD115-26 /// SNORD115-7 /// SNORD116-22 /// SNORD116-28 /// SNORD116-4 /// SNRPNSOCS3RP11-504P24.4PEA15 PLA2R1RP11-512M8.5CYP20A1 POLR2LRP11-527D7.1ANKRD28 LIFR-AS1RP11-532F6.3ARRDC4 NRG2RP11-546K22.1SWAP70 ST8SIA3RP11-557L19.1SSX1 LARGE2RP11-560J1.2EIF4H LINC01564RP11-561O23.5KARS PROX1-AS1RP11-566E18.3SLC26A10 CENPHRP11-567M16.1ZSWIM1 CCDC85ARP11-572C21.1MCEE GABARAPL1RP11-61A14.2HIST1H3G COQ4RP11-61J19.4PTDSS1 SAMD14RP11-626K17.3LUC7L3 DLG5-AS1RP11-638I2.6KPNA4 APOBEC2RP11-69I8.2TMEM182 POLR1CRP11-6F2.5BOLA2 /// BOLA2BARHGEF6RP11-701H24.2PRKCB PFN2RP11-701P16.5VAMP7 PCK1RP11-709B3.2ALOX12P2 SHISA7RP11-798G7.6ZNHIT3 SPINT1-AS1RP11-79H23.3FLJ41455 CD302RP11-7O14.1YIF1B UBR4RP11-806H10.4LOC101927391FFAR1RP11-819C21.1SYT9 SRGAP1RP11-81A22.5MCM3 COX6CRP11-838N2.4RPF1 PCYOX1RP11-849F2.9CCDC93 GLDCRP11-84C13.2TRPM5 GNAQRP11-862G15.2ABHD14A-ACY1 /// ACY1RNF114RP11-883G14.1MIA2 GTF2IP4RP11-91K9.1C16orf91 MTMR4RP11-923I11.1BDKRB2 ZBTB47RP11-923I11.4CACUL1 LOC101927911RP11-93L9.1UBR5 SPCS3RP11-95P2.1QSOX2 ASIC3RP11-97O12.2RBMXL1 LOC105369147RP2 CASP3 CHN2RP3-468B3.3DOLPP1 CNOT7RP4-594I10.3PCDH12 LINC00346RP4-737E23.2F12 TMEM240RP4-794H19.1TMED5 EVA1BRP4-794H19.4PPP1R2 SLC25A25-AS1RP4-809F18.1RAB10 SERAC1RP5-1021I20.2PGM3 PARP10RP5-1086K13.1NQO2 SHROOM2RP6-206I17.3RTEL1-TNFRSF6B /// TNFRSF6BRCC2

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RP6-74O6.2INTS3 TDP1RP9 SLC25A28 FGF14RPA1 RNASEH2A ZNF426-DTRPAIN AHSP SYF2RPGRIP1L ARHGEF15 TRIM41RPL10A MMAA NAMPTRPL11 CCDC84 RBPMS2RPL12 MRPS6 CAPN15RPL13A TMEM259 ZNF821RPL15 NAGS HLA-DRARPL17 LOC100130428ANKRA2RPL18 TVP23A PTSRPL21 STARD9 LINC00884RPL22 RP11-307L14.1 /// RP11-307L14.2ACOX2RPL23A PRO1804 WBP2RPL26 EWSR1 DHTKD1RPL26L1 CDK5RAP3 EXT1RPL27A TH ITGB2RPL3 CUL3 NDRG3RPL30 RPL7A /// SNORD24 /// SNORD36A /// SNORD36BUBE2MP1RPL31 ENTHD2 BCL7ARPL32 LINC-PINT RCBTB2RPL35 NSUN6 FFAR2RPL35A P2RX1 MRTO4RPL36A STK40 UBE2Q2P1RPL37A SLC25A26 GRIN2CRPL4 CDC42 ARMH3RPL5 RBM42 YTHDF3RPL6 CYP1A1 EFCC1RPL7 C2orf69 SLC7A4RPL7A LOC100131496HTRA3RPL8 NPAS3 LOC100289361RPL9 GPATCH4 ZNF350RPLP0 TENC1 RCAN3ASRPLP2 CREBZF RPL14RPP30 ARPC4 CD163RPRD2 LOC100422781C1QTNF3-AMACRRPS10 LOC100506538 /// NDUFAF6SF3B2RPS14 OBFC1 MFSD6LRPS15A BRD7P3 UCK2RPS16 PCDHGA4 ZNF496RPS17 ULK1 CTXN1RPS17L PCDH9 LIMS2RPS18 GSK3B TMEM255ARPS2 FAHD2A /// FAHD2B /// FAHD2CPGRIA3RPS23 MMP10 TMEM94RPS24 ARHGEF4 /// LOC101930241ORC6RPS3A EIF3D PRR11RPS4X DIO1 ARHGEF26RPS5 FAM129B SNX18

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RPS6 MIR6840 /// PILRB /// STAG3L5P-PVRIG2P-PILRBZNF219RPS7 ERVH-1 KRBA2RPS8 KLRB1 RPS6KA2RPSA LRRC16B UBL3RPSAP58 RP5-855D21.1DBF4RPUSD3 NPTN-IT1 ERO1BRRAGD DDX17 MOSPD2RRAS FBXW11 KPNA6RRM1 HPRT1 MBOAT7RRP36 FAM66C /// LOC101928910HNRNPRRSAD1 FAM135A FBXL17RSAD2 MAPRE1 FBXW11RSPO3 HDHD1 ABCC4RTKN USB1 HLA-JRTN3 SAFB2 ANGPT2RTN4RL1 MROH7 LINC00342RTP4 ATP6V1D PRRX1RUFY4 C2CD5 LGR4RUNX3 ASL SNHG12RWDD3 WIPF3 NNMTRXRG CLK2 GTF2BS100A14 IGHA1 /// IGHG1 /// IGHG3 /// IGHM /// IGHV4-31 /// LOC100293211NCK2S100A8 LINC00967 ICE2S100A9 NUDT1 GLRA3S100B SAE1 SRCIN1S1PR5 CDCA4 RGS9SAA1 KLHL3 MIR29B2CHGSAA2 NOL10 TYW5SAA4 PIN4 UBE2G2SAE1 RALBP1 CMPK2SAMD13 VPS26A JAK3SAMD4A C20orf24 /// TGIF2-C20orf24KIAA0825SAMD9 NDUFA1 LINC01146SAMHD1 BC043266 /// RP4-568F9.6TUG1SAMM50 SLC25A24 CCDC121SARDH PSMB3 XPNPEP1SARM1 C1orf116 PCDHGA2SARS2 RBM5 KCNN3SAT1 ADAMTS12FAM126ASAT2 TTC28-AS1 RNGTTSAYSD1 LOC101929112EIF2S3BSBK1 GTPBP4 /// IDI2ULK3SBNO2 KLF16 EML3SCARB1 CMAHP BTBD18SCARF2 RP1-118J21.25PXNSCD5 LINC01296 /// LOC100653149 /// LOC102725127SNX9SCFD1 RP11-792A8.4FAM76BSCG2 CX3CR1 DOK1SCG5 CERS1 /// GDF1GATD1SCGN LOC100133039ANXA5

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SCML1 DKFZP586I1420OXSMSCML2 GNRHR2 SPARCL1SCO1 SLAIN2 FOXF1SCO2 FOXC2 MKI67SCOC KCNAB1 BARD1SCRG1 SRR C1orf220SCRN3 B3GNT7 EMC9SCRT1 INIP ANXA9SCTR NDUFS3 TSTD1SCYL3 CD52 PAFAH1B2SDC1 TAPT1-AS1 OSGEPSDC2 VPS9D1 PRKCISDCBP2 VPS13A CFC1BSDHA TUBA3C /// TUBA3DCCDC18SDPR CCL20 GGNSEC11A PIGA ACTN4SEC11C CLP1 ZDHHC16SEC14L5 C7 FAM86C2PSEC14L6 ANK1 POSTNSEC63 TSPY1 CRIP1SECTM1 NR0B2 CDC25ASELPLG ENGASE NSD1SEMA4G SQLE LINC01547SEPHS2 PON2 ABCC6SEPP1 NHP2 JAZF1SEPT1 ENOPH1 IL27RASEPT3 TTC18 TMEM51-AS1SEPT4 SFN GSTM2P1SEPT5 ZNF638 HEG1SEPW1 LRRC59 GATA4SERGEF TIPARP UBR1SERP2 DKFZp434J0226ZBTB41SERPINA10LXN STAMBPL1SERPINA4 FAM160B2TRIP13SERPINA5 C5orf22 TMEM223SERPINA6 TCTN1 DFFASERPINB1 CSF3R POLR3CSERPINB7 CYP21A1P /// CYP21A2GABPB2SERPINB8 PLP2 TNKS2SERPINB9 KATNA1 HAT1SERPING1 RAPSN CYSRT1SERTAD1 SEC14L2 CALM2SERTAD3 TMOD3 PPP3R1SERTM1 LYN LARP4BSFMBT2 COQ4 IMMTSFRP5 NUDT15 ANKMY1SFT2D2 LARP1B FLIISFT2D3 ERO1L RRP9SFTA1P RAB38 ERMNSFTA2 PSMB8 ARSA

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SFXN4 UGP2 SASH3SGCD CDH12 DUSP9SGCG MCF2L-AS1LRRC75BSGK2 CD82 WSCD1SGMS1 MYO1E PCNASGOL2 CERCAM POM121CSGPP2 SNX6 NFAM1SH2B1 IRF8 LEMD3SH2B3 GZMH KIRREL3SH2D3C HNRNPA3 FANCD2SH3BGR PTP4A1 SUPT3HSH3D19 LOC101928189 /// RSRP1CGRRF1SH3RF2 JUP KLHL3SHB GOLGA7 MGAT4BSHBG GS1-164F24.1NCOA7SHE MELK NUMA1SHF GSAP TMEM74SHISA5 MSH5 /// MSH5-SAPCD1 /// SAPCD1MTHFRSHISA7 EPPIN /// EPPIN-WFDC6CCDC130SHMT2 MYO18A /// TIAF1BRWD1-AS2SHROOM1 G3BP1 DRD2SIDT1 MAPKAPK2LOC100287497SIGLEC1 UBN2 NOX4SIGLEC10 LOC730102GAMTSIGLEC11 ALDOC KCTD14SIGLEC7 CLVS1 RPAP2SIGLEC9 BZRAP1 TFE3SIGMAR1 RGS1 A1BG-AS1SIPA1L1 PEX26 TUBB3SIRT5 CD1C EIF4ENIF1SKA1 IRAK1 WACSLA2 PLEKHA3 STX3SLAMF1 PTPN4 KPNA1SLAMF7 PRPF4 ALDH3A2SLAMF8 LOC101929855 /// LOC102724851ZFYVE9SLC11A2 MLLT4-AS1ALG6SLC12A7 LOC285419CYP27B1SLC13A5 FAM114A1TCERG1LSLC15A3 LRFN1 PIM3SLC16A11 CHMP4B CYB5R3SLC16A3 CENPT C2orf42SLC16A9 TEX30 ZNF709SLC17A4 CHD2 SNAP29SLC17A5 EPHB2 ASMTLSLC18B1 JAGN1 GIMAP8SLC1A1 DFFA GID8SLC20A2 LOC102724275CMBLSLC22A3 NQO1 MICALL1SLC22A4 RP11-295G20.2IL17RBSLC23A2 RASSF1 CSPP1

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SLC24A1 RP1-151F17.2SGMS2SLC25A11 DCTPP1 BIRC2SLC25A15 OBSL1 C21orf58SLC25A19 ZFAS1 FAM86B1SLC25A21 GABBR1 ACDSLC25A22 CD74 LINC01014SLC25A23 C4orf32 PKD1SLC25A28 CCBL1 1-MarSLC25A29 LOC101928483CBLBSLC25A3 USP32P2 GCLCSLC25A34 SRFBP1 KIF1BPSLC25A35 LOC101928424WASHC4SLC25A39 ELOVL5 SIGLEC16SLC25A42 EEF1E1 BZW1SLC25A51 SEC13 ACTN1SLC25A6 MFAP4 HRKSLC26A2 CEP44 MAP3K9SLC26A4 RPN2 CKAP4SLC27A3 NUP37 ID2-AS1SLC27A4 NPHP4 MANBASLC27A5 FAHD1 QDPRSLC28A3 NAV2 TBX3SLC29A1 TRAM2-AS1TCN1SLC29A2 BCL10 EIF5A2SLC29A3 RP11-873E20.1TMCC1SLC29A4 PRMT5-AS1PTGS2SLC2A5 LOC101930630 /// STRCPON1SLC2A6 DENND3 PPP6CSLC30A5 ACTR3C STEAP1SLC30A7 SMPDL3A INSYN1SLC30A8 LOC102724975TEAD4SLC31A2 WNT10B LOC100507507SLC34A2 CSNK2A1 TMEM183ASLC35B2 Y16709 SIGLEC15SLC35D1 MED6 FOXD2-AS1SLC35D3 CDK6 NLGN4XSLC35F1 MAL2 CAPN13SLC35G1 HDC ATRNSLC37A1 ZNF174 HMGN2P46SLC38A11 TOMM40L KIF5BSLC38A6 DPP3 BTBD11SLC39A10 MAPK1 PRDM16SLC39A14 MFSD2A ULBP3SLC39A2 IGHV5-78 TSHRSLC39A5 GSR RNF19BSLC3A1 CYTH1 CSF1SLC41A3 LOC100128288RHEBSLC43A3 ZRANB2 CYP7B1SLC44A2 GRIA4 RNF150SLC44A3 PTPMT1 KLHDC9

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SLC45A1 LINC00893 /// LINC00894CTNNB1SLC45A3 CDK10 LOC100507564SLC48A1 TMEM33 PRKAG1SLC4A3 HAUS1 KCNK12SLC4A4 DUSP14 APLNSLC5A10 AIFM1 EIF2AK4SLC5A5 MGC4294 SLC9A1SLC6A14 CAPN3 NCBP3SLC6A20 C19orf26 XPO4SLC7A14 ADAT1 SSH3SLC7A5 CXCL8 LINC01123SLC7A8 CDK14 STX17SLC9A8 MAPK8 FBXW9SLCO4A1 ATP5J2 PDCD10SLCO4C1 RBM17 AHSA2PSLFN5 ADAP2 RBM4BSLITRK5 DEFB124 RPARP-AS1SLITRK6 TBC1D2B ZNF626SLMO1 BRI3BP /// THRILFAT4SMAD3 SRP14 FADS1SMARCA2 RP11-796E2.4CCR6SMARCD2 ITPR3 C1QTNF3SMIM1 CCDC101 C17orf49SMIM10 TTC31 PCDHGC5SMIM11 TMEM38B RNLSSMIM18 EHMT2 SCARF1SMIM4 POLR3C ANKRD22SMIM8 RP11-135A1.2CYP1B1SMOX LOC646014RIPOR1SMTNL1 TSG101 AKIRIN1SMURF1 KANK1 ST3GAL4SNCAIP RPS6KA1 SEC11CSNCB RP2 ARHGAP31SNCG LOC101928173PLPP4SNHG1 EME2 IPMKSNHG6 SARNP TM9SF1SNHG9 MSANTD3 PYURFSNPH SCN7A GPATCH8SNRNP25 DDA1 ZDHHC11BSNRNP48 MST1 MCF2L-AS1SNTA1 ZBTB6 MAMLD1SNTG2 ODF2 TRIM59SNUPN LOC100130417ARNT2SNX10 COA7 MEDAGSNX2 LOC100130429NAIPSNX20 LOC100129518 /// SOD2GNMTSNX21 ELF3 CZ1P-ASNSSNX30 LOC285889CLGNSNX5 ACVR2A SMG1P2SNX6 AC012065.7GPNMB

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SNX7 CD69 FAM53BSOAT2 TMEM62 FBXO45SOCS1 LOC101928288MTRSOCS3 LHX4-AS1 GGA1SOD2 LINC01420 RAB14SOGA1 HN1L SLC2A2SORL1 STX3 GNB5SORT1 SMOX CDH2SOX18 HNRNPAB PDAP1SOX3 S100B PCDHB12SOX7 FOXJ3 PSRC1SP100 CHRM3-AS2SERPINB1SP110 ANKRD10 SRSF5SP140L GRPEL1 MFGE8SP6 YARS ENTPD6SPAG16 FRMPD1 ADCY4SPATA16 MRPL39 CAMK2N1SPATA21 SLC6A16 NXPE3SPATA7 RP11-61L19.3ZNF287SPC25 IL17D BUD13SPDL1 CHRDL2 HOXB7SPDYA AMFR METTL2ASPEN LYRM4 ZADH2SPG7 GSTO1 GLRX2SPNS3 PRICKLE3 UBDSPPL2A RP11-138I18.2VEGFCSPR AMICA1 RAB8ASPRR2A OSER1 ACKR3SPRR2D MRPL40 ATP1B2SPSB4 GALNT16 ADGRG5SPTLC3 LOC100506990EXPH5SPTSSA AX748339 GADD45ASPTSSB CTSW HADHSQRDL ZGLP1 VIPAS39SRCRB4D TUBB2A /// TUBB2BTXNSRD5A1 FOXD2 FAM24BSRGN KIAA1377 TBCBSRP9 NDNL2 SUCLG2SRPX SAMD1 DPM3SSR2 ATOH7 P4HA3SSSCA1 UBE4A GLO1SSTR2 SPATA18 GSPT2SSTR3 CDK2AP2 ZNF236SSTR4 CSF1R ZBTB2ST14 TPM1 ADTRPST3GAL2 KRT8P12 DCKST3GAL5 ZNF367 AKR7A2ST5 MIR31HG NETO2ST6GAL2 TDRD9 DEPP1ST6GALNAC6CLK1 RAVER2

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ST7 YWHAZ SS18ST8SIA3 RRS1 ZNF597STAP2 LOC101930112 /// SPG7NOL4LSTARD4 SUDS3 GALNT2STARD5 MTFR1L SPARTSTAT1 ARNTL2-AS1SLC39A6STAT2 C6orf164 PMM1STAT5A OPTN PDK3STAU1 CASK CTAGE11PSTEAP4 TMEM130 MISP3STIL LCN12 LOC100134368STIM2 ZDHHC5 PNPLA5STK16 EIF4EBP1 OSCP1STK32A BTN3A1 S100PBPSTK32B DRG1 LOC645513STK32C A2M-AS1 CCDC74BSTK33 FAM96B FAM111BSTMN1 CCDC18 UCKL1-AS1STOML2 LOC283713 /// OTUD7AFBH1STON1 HLF FKBP9P1STRBP FAM156A /// FAM156BESDSTS AKT2 LDAHSTUB1 CCDC25 MEAK7STX10 SPTY2D1 NUDT14STX11 C16orf86 LOC105371485STXBP1 AK054988 /// TPTE2P1 /// TPTE2P1TMEM271STYK1 RP1-102H19.8SLX1A-SULT1A3SUGP2 BC039673 SLX1B-SULT1A4SULT1A1 ELOVL1 /// MIR6734WBP11SULT1B1 RING1 GNAZSUMF1 WDR73 CRLF3SUMO1 ACVR1 GJB1SUOX MSS51 LOC101928728SURF1 ZNF436 LDOC1SURF2 PNP LOC100130872SURF4 MRPL32 KLHL23SV2C RPRML HDDC2SWI5 PSME4 UNC45ASYCE2 C19orf66 NELL2SYNGR1 ZNF76 DSPSYNGR4 MAU2 DYNLRB1SYNM DIAPH1 C8orf58SYT13 SERPINB2 TIMM23BSYT17 BIN2 PCGF3SYT6 SYNE2 FAM120BTAAR1 C10orf2 SMAGPTAGLN ATP6V1E2 /// FLJ41757AP1S3TAP1 ATCAY ZNRF3TAP2 ARNTL2 SNORCTAPBP EIF5 /// SNORA28SUV39H1

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TAPBPL RRAS2 FAM24B-CUZD1TARBP1 SNAPC1 LINC01886TATDN1 MECR SERTAD3TAZ BC045788 PINX1TBC1D13 CTBP1 MROTBC1D16 ZNF276 MYL9TBC1D3C MMADHC TSG101TBC1D3G C21orf33 TNIKTBC1D3H FPR1 ZNF571TBC1D7 PRELID1 VAMP1TBC1D8 PPTC7 KMT5ATBCK NFKB2 AXIN2TBK1 PPDPF SLC22A15TBKBP1 NPM1P22 /// NPM1P22FZD7TBX21 GLIS2 ALMS1-IT1TCAIM MIR34A ATL3TCEA2 MAP1A NPLOC4TCEA3 LOC101930578 /// TPTE2P2CCDC141TCEAL1 PXDN NUCB2TCEAL5 PPP1R15A HEPHTCEAL7 ZDHHC4 SLC12A9TCEAL8 ATP5I TMEM9BTCERG1 PIP4K2C FAXDC2TCF21 RGS3 TTC9TCF7 FOXO1 KMT2ATCHH C12orf73 ACVR1CTCHP HSCB BANK1TDRD6 ME2 HID1TDRD7 PGGT1B CYBC1TDRP NRBF2 SEMA4CTEAD4 SLC25A16 PRPF40ATESK2 MRE11A ASCL1TEX264 MAPKAPK3L1TD1TEX29 ATF7IP SGIP1TEX30 KIF21A NFKB2TFAP4 TEN1 /// TEN1-CDK3HELZTFB2M RPGR EMBTFCP2L1 ADCK3 SALL1TFE3 FAM153A /// FAM153B /// LOC100507387MRPS26TFPI2 SNRPF PEX11ATGFB1I1 ANXA3 CAMSAP3TGFB2 FBXO28 CASZ1TGFBR1 KRT72 MED17TGM2 MLIP ILKTHAP1 ZMPSTE24 SMOC1THAP4 C14orf39 MGMTTHEM4 SDE2 REG3ATHEM6 PDX1 QSOX2THEMIS2 GLTP USH1CTHRA CEACAM19SENP1

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THY1 NUMB DNLZTHYN1 MCM6 GLRXTICAM1 RRM1 SVBPTIFA RP11-10K16.1SHFLTIGD2 CCDC112 MKXTIGIT AHCY ENPP1TIMM13 NME1-NME2 /// NME2LIMS3TIMM21 KRT81 TXNRD3TIMM22 SH3RF2 GRAP2TIMP3 R3HDM2 HNF1BTINCR CCDC66 CCDC14TKT DGKZ FLVCR1-DTTLCD2 MTCH2 UACATLDC2 PGAP2 ELF3-AS1TLR2 LRRC16A SURF4TLR3 SPATA5L1 DAAM1TLR8 SPPL2B PQBP1TM4SF1 HIP1R SMG7TM4SF18 MFSD1 TMEM187TM4SF4 CD5 SUMO1TM7SF3 SLC4A7 SETD5TMA7 MFHAS1 LOC100506302TMC3 NUFIP2 ABRACLTMC7 ABCC10 PDLIM2TMC8 DDX50 EGLN3TMCO3 PRPS2 CAP2TMED3 LIN54 TYK2TMED4 CSE1L CT75TMED6 UBAC1 CHAC2TMED8 IL11RA MBTPS1TMEM106ADDX39A SLC25A13TMEM106CBAHD1 KRT222TMEM121 FBL BEX2TMEM125 BANK1 SPDYE5TMEM130 GHET1 LOC101927495TMEM132CCD207 PLLPTMEM140 PTPLB TTC7BTMEM141 DNAH1 PACS2TMEM145 LOC101929889 /// SPNEML4TMEM14A ETHE1 MPDZTMEM14B SPSB2 INIPTMEM14C PPP2R5C AFAP1L1TMEM150CTIAL1 SEPTIN6TMEM151ANXF2 /// NXF2BZNF142TMEM158 PITHD1 TMED1TMEM163 MRFAP1 ANKRD50TMEM165 ZNF678 ANKS1BTMEM17 TNC PIP4K2CTMEM170ANEGR1-IT1 UBE2G1TMEM171 INTS8 LOC102724135

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TMEM182 MCM3AP-AS1THYN1TMEM183ARYR1 C2orf76TMEM19 NR2F1-AS1N4BP3TMEM199 COX7A2L PREPTMEM2 TAF1C NUDT18TMEM201 NACC1 MTERF2TMEM204 EPS8L3 AGAP3TMEM206 GPR113 RPAP1TMEM215 ACTR8 GUSBP3TMEM217 TMEM161B-AS1OAZ1TMEM239 TRIM4 LAMC3TMEM240 VIPR1 MSMBTMEM241 HNRNPH2 /// RPL36A-HNRNPH2PLXNA4TMEM242 RBM15 CNOT6LTMEM245 CTBP2 CCNL1TMEM249 C6orf47 CARFTMEM25 TSNAXIP1 FBRSL1TMEM253 HIF3A ACRTMEM26 GMFB LINC01503TMEM38ARP11-348N5.7YY1AP1TMEM41B ODF2L ALDH1B1TMEM44 SNX9 MOCS3TMEM50A ADIPOQ XXYLT1TMEM52 RP11-468E2.5BRAFTMEM55A PRDM7 LGI3TMEM57 TBCB LOC644554TMEM72 CROCCP3 MOSMOTMEM74 NFKBIE OTUD4TMEM80 VPS37C GNETMEM9 GPR110 NOVA1TMEM97 PLA2G6 POU6F1TMIE LOC727820KIF24TMOD1 FGFBP1 CHORDC1TMPRSS3 PLXNA3 LOC114841035TMSB10 THG1L RGL1TMSB15B CHL1 PPP1R14ATMSB4X INTS12 SRRM2TMUB2 LENG8 PAPOLGTMX2 C3orf70 TUBB2ATNC FAM138A /// FAM138B /// FAM138C /// FAM138D /// FAM138E /// FAM138FSULT1C4TNFAIP1 SLITRK6 KIF27TNFAIP2 FAM188B /// INMT-FAM188BPOLR3GTNFAIP3 ZNF469 FAM174ATNFAIP6 LOC101930150 /// NF1C1RTNFAIP8 GPR133 GRHL3TNFRSF14 TMEM208 HTD2TNFRSF18 PTGIR PCSK7TNFRSF1B SPAG5 C2CD3TNFRSF4 KRTAP2-3 /// KRTAP2-4DROSHATNFRSF8 EIF2A ATP6V1G1

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TNFRSF9 TTC9 APCDD1TNFSF10 SPRR2B ACOX1TNFSF13B PC CAND2TNFSF18 LINC00969 /// SDHAP1 /// SDHAP2SMIM2-AS1TNFSF4 MRPL52 PSEN2TNIP1 TPM4 PPP1R12BTNIP3 PHLDB2 YTHDC1TNK2 HDAC11 GS1-124K5.11TNN AL832163 HCG11TNNC1 PPP1R16B GTF3C2TNNI2 MRPL11 ZFAND4TOB1 SLC35A2 ASPNTOE1 RP13-39P12.3NR2F1-AS1TOMM22 EIF3K SNX29TOMM34 ATF7IP2 LZICTOP1 GAS8 TIMM29TOP1MT ADRM1 CLDN12TP53I3 KLRC1 /// KLRC2IGSF22TPD52 RFWD3 OXLD1TPD52L1 GABRB1 FOXO3TPM3 MYO9A ZNF563TPPP3 SCAF4 ZNF157TPRG1L OS9 WIPF1TPST2 NF1 KRT40TRAF1 SUPT4H1 SSBTRAF3IP2 DSTNP2 TBC1D20TRAFD1 TMEM92 TMEM179BTRAIP AX746755 /// RP11-774O3.3SLC36A4TRAPPC2L MYF6 MSH5-SAPCD1TRAPPC6A DSERG1 NKIRAS1TREH PLEKHB1 NIF3L1TREM2 CBR1 DACT2TREML2 AMIGO3 /// GMPPBPCDHB2TRHDE ULK3 LINC01612TRIB1 NAP1L1 MBOAT2TRIM10 LINC00327 C19orf48TRIM14 KSR2 APOBRTRIM21 NSUN5 RAB11FIP2TRIM22 KCTD19 GALNT3TRIM25 WDR13 SSR2TRIM26 GOLGA8N MYO3ATRIM31 CYP2D6 ARMC7TRIM38 CCDC6 MLXIPLTRIM40 GPBP1 SEPTIN5TRIM45 ZNF252P ANKLE2TRIM46 UBE2Q2L MMP11TRIM50 NOLC1 LAMTOR5TRIM55 NBPF10 /// NBPF14 /// NBPF26RNASEH1-AS1TRIM56 CTD-2310F14.1TCEAL4TRIM59 PPOX FAM114A2

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TRIM63 TRIM32 LRRC61TRIM69 CD2 PTGR1TRIM7 TCEA1 ROR1TRIP12 SUMO3 TPM2TRIQK EPT1 SAPCD1-AS1TRMT61B ATAD1 HMGXB4TRNP1 DCBLD2 G3BP2TRPM5 COX15 HDAC6TRPM7 PNPLA4 SLC15A4TRPV1 NEK9 C15orf65TRUB1 NOL7 SASH1TSC22D1 KLHL9 CCDC58TSC22D3 GRPEL2 GSTM5TSPAN13 DNAJC7 EDIL3TSPAN2 FAXDC2 LINC00865TSPAN7 BMS1P5 AGO4TSPAN8 SLAMF1 ACTG1TSPEAR SYNPR KIF7TSR2 TNXA /// TNXBNR5A2TSTD2 CROCCP2 IL1R1TTC13 SYNGR4 RN7SL832PTTC17 TAS2R45 MTCH1TTC3 ZBTB21 INO80B-WBP1TTC39C RS1 HCG26TTLL12 SLC52A2 TACC2TTYH1 WASF2 SYNMTTYH2 RNF7 SYNRGTUBA8 TICAM1 LRRC4BTUBB4A MAPK9 OTUD3TUBGCP5 SERINC2 MIR4453HGTULP3 ZDHHC3 B3GNT10TXN2 SAMD11 FKBP8TXNL4A BROX PIK3IP1TXNL4B SOX11 ZBTB8ATXNRD2 LOC101928045AFAP1L2TYMP NEFL CD2BP2TYSND1 EIF1AX RFXANKUAP1L1 PAN2 FRMD8UBA7 MAGI1 CCT6P3UBALD2 GEMIN7 BMS1P4-AGAP5UBD LOC102723678 /// LOC102723709USP46UBE2D3 C7orf49 TTC13UBE2E2 LIMS1 ZNF256UBE2L3 PPARA HTR7P1UBE2L6 CCT6A CCL26UBE2O STK17A DCBLD1UBE2Z LOC100996747 /// LOC101929876 /// RPS26 /// RPS26P11ADMUBE3D IDH3G UBALD2UBE4B RBM39 HAUS2UBR2 BMPR2 LOC105375304

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UBTF ARHGEF40 LOC100506990UBXN4 LDLRAD3 MYL6UCHL1 PPAPDC3 SOS1UCHL5 COX5B LIPHUCN2 FUK IQCGUFC1 SPATA16 AKR1C2UGGT1 SRP9 FGD1UGGT2 CAPN2 APOLD1UGT1A6 ARPC2 GNB3UGT2A3 ZNF528 NOL3UGT2B15 TSC2 POLR2BUGT2B17 RAB26 NRXN1UGT2B7 PROSER2 LOC101928123UGT3A2 ENPP4 TRIM32UNC45A HMGN3-AS1ERI1UNC5B KLHL5 DTYMKUPB1 RP1-179N16.6GUK1UPK1B LINC00152 /// LOC101930489 /// MIR4435-1HGGATA6UQCRH PROSC VSIRUQCRQ EGLN1 FBXL7USE1 LOC101927268 /// LOC102724851HS3ST3B1USF1 KPTN VWA5AUSF2 CYP4F11 RGS3USP18 CDH6 WASUSP27X TMEM116 MUS81USP34 HMGA1 PPP1R36USP4 RGL2 STMN2USP41 PINX1 IGF2USP43 DNM1P46 SPNUSP48 KIAA0895L CACNA2D3USP51 LOC100132057SH3BP5-AS1UTRN PTPRH GPC1VAMP5 MALL FAM171A2VASH1 FCGR3B SZT2VAT1 ZSWIM8 TMEM100VAT1L ZBTB16 LINC01370VAV3 LZTR1 ZNF702PVDAC3 LOC101928861UNC5AVEGFB KDM1B BEX3VEGFC ZNF185 LANCL1VEPH1 ACSL6 SLC11A1VGLL3 FAM192A GGT7VIL1 FMO2 HDAC5VIPR1 CRB3 SIRT1VKORC1 ZNF703 COQ6VKORC1L1 GNRHR SCGB2A1VNN1 AKR1C2 /// LOC101930400INO80CVNN2 LOC57399 TSC22D4VNN3 PIGN GFRA1VPS13C ZNF124 LOC730101

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VPS26B CHKA BYSLVPS37D FBXW7 MMGT1VTCN1 LINC01126 DANCRVTI1B RNF121 PDS5BVTN AK023627 /// TCTE3RNF139VWA2 SFTPD COMMD1VWA3B SMAGP POLBWARS SIGLEC17P SLTMWDFY1 FAM101B MCTP1WDR13 RANGRF JOSD1WDR41 KLHL23 /// PHOSPHO2 /// PHOSPHO2-KLHL23COMMD7WDR49 WDFY4 APOOLWDR5 LOC285847MRPL40WDR83 LOC101927588INPP1WDR86 RRN3 IDH2WDSUB1 DDT /// DDTLABOWHAMM ANLN TEAD2WI2-1959D15.1LOC102725188 /// LOC727820PALD1WIPF3 LOC100507283CMC1WLS RP11-1275H24.2PLAC8WNK4 TAF1D VAMP5WNT16 LINC01268 ZNF799WNT2B AC083843.1BAK1WNT5A HNRNPU-AS1U2AF2WNT5B NCOA3 TMCC2WNT7A HHLA2 NEDD8-MDP1WRNIP1 PCDHB7 TRIM37WSB2 TTC25 SCTRWSCD1 TNK2 ARPC3WSCD2 LINC01138 MFSD4AWTAP PRPF3 ERMARDWTIP HNRNPLL ADH1CXDH LOC155060NAP1L3XIRP1 TMEM50A KIAA1328XK ZFP91 MAP2K1XPNPEP1 POFUT1 LOC653160XXbac-B135H6.15C1orf228 NIPAL1XXbac-BPG246D15.8DCAF4 CLEC14AXXbac-BPG299F13.14BRE-AS1 RMND5BXXbac-BPGBPG55C20.2WBP11 WNT5AXYLB MED12 APOBEC3CYBEY ATP6 GNAO1YBX1 GUSBP1 /// GUSBP4 /// LOC100996497SRSF9YEATS2 GPX4 STARD7-AS1YPEL1 JOSD1 KAT2BYPEL5 TJAP1 SLCO4C1YWHAH BC043227 VWA7Z83851.1 WDR90 ANKRD36CZADH2 MMP1 BLOC1S2ZBP1 VIMP VPS37D

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ZBTB12 THEMIS P2RY2ZBTB18 STAP2 PRR22ZBTB20 CHD9 RSKRZBTB42 HECTD4 MRPL45ZBTB7C MMACHC CAMK1ZBTB8A TNFSF11 LOC150776ZC3H12A GOT1L1 PLK4ZC3H12B RALB DGKGZC3HAV1 WDR25 SORBS1ZCRB1 CALCOCO1 UHRF1ZDHHC1 SEPSECS-AS1OTUD1ZDHHC13 DOC2A LOC105373553ZFP36 KLHL6 LRRC58ZFP62 FAM43A ALKBH3ZFP69 METTL6 ZNF655ZFYVE27 CCSER2 PA2G4ZKSCAN1 LOC101927027POC1AZMYND19 VPS4B PTAR1ZNF121 LOC100288778 /// LOC101930154 /// MIR6859-1 /// MIR6859-2 /// WASH1 /// WASH2P /// WASH3P /// WASH7PMKLN1-ASZNF148 PARVG SLC4A3ZNF174 CAPN10-AS1SFR1ZNF226 LRRC37A3 USP5ZNF23 COX1 ILDR2ZNF267 LOC102724362RASAL2-AS1ZNF276 SNAPC2 TENM2ZNF284 GGTA1P KCNB2ZNF296 ZNF165 IL1RAPZNF3 MRPS18A RP9PZNF30 C21orf15 /// LINC00417USP53ZNF318 CDR2 /// LOC101060399TIMM8AZNF32 CR936796 PROCRZNF33B RRN3P2 LINC02246ZNF34 IGFBP3 NLRX1ZNF346 LOC101929378SPHK1ZNF358 PRDM5 PODXL2ZNF423 MRPL19 TMEM98ZNF428 AP3M1 YWHAEZNF438 TMEM179 CPLANE1ZNF493 DPY30 NEDD4ZNF524 ARL8B TOR1BZNF544 SNHG19 NSMCE3ZNF568 PSMD6 IFT122ZNF575 BCAS2 LINC00900ZNF648 CD34 CEPT1ZNF664 LOC100134445AKAP3ZNF667 OSR2 LINC00242ZNF667-AS1BOC ARL8BZNF684 NDUFB5 TMEM8BZNF708 P2RY2 FOXS1ZNF738 C16orf72 TTLL12

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ZNF74 ISYNA1 SEC24BZNF771 LOC101927746PABPC5ZNF781 NFATC4 ATG2BZNF792 MOB3B WNT10AZNF814 FAM95A ARCZNF833P SHC4 SLC39A4ZNF878 PDPR TRAPPC2ZNF883 TFG DMAC1ZNF888 ZMAT1 HAP1ZNF93 ALG11 /// UTP14A /// UTP14CMFN1ZNF98 SCML2 CSKZNFX1 CNOT3 TUT1ZNHIT1 GSTA1 WDR73ZPBP SLC4A9 FAM151BZPLD1 RHOD TRPC4ZSCAN21 RP11-314N13.3SESN3ZSWIM4 CCDC122 LOC101928100

NUDC CSNK1G1RP11-174G6.5ADCY7LOC100506107RFX2TMEM132CLOC101928504DNAH3 DUSP3COLGALT2 SMIM22SIX2 RNF138DDX5 LINC01574ZDHHC8 HRASPRODH2 OLFM1GK3P KCNH1LOXL2 RNF144A-AS1RP11-1109F11.3PHYHIPAC007401.2LINC00921MPP5 LCORHIST1H1B IFI35ARHGAP9 GMFBDCTN5 WDR12SUCLG1 CPXM2LOC221814HSD11B2C3orf43 ANKRD13CPRIMPOL DAB2IPPPP1R7 CD22PRKCDBP RBM20VSIG4 COL8A1GOSR1 PIGWENTPD2 LOC100130331POP4 PRKG1VKORC1 SEPTIN2C1QA RPL23AP87LOC100288778 /// LOC101930154 /// LOC102723897 /// MIR6859-1 /// MIR6859-2 /// WASH1 /// WASH2P /// WASH3P /// WASH7PMAPK4SNX20 NT5CHNRNPC POP1

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HTATIP2 NDUFAF4MRPL37 ZNF644PRH1 /// PRH1-PRR4 /// PRR4SLC26A6RP1-74M1.3BHLHE41MLLT1 PYGO2MARCH11 PHF14LOC100507472 /// PCSK6TMEM74BAK000798 TAF3ADCY10P1 MTX3LOC441204IDH1DCDC1 /// DCDC5ENTPD2SNHG22 U2SURPCMTM1 PIK3AP1KIAA0930 ZSCAN20SRSF5 POU3F1NPAS4 BMS1P1RP11-1109F11.5LINC00839LAMA5 NCLSDAD1 LRRC37A4PSYN2 CXCL6MIS18A TNNI1GMEB1 REPS1CRLS1 KBTBD11CDC123 SLC15A3KRT19P2 CARS2TMEM198BSPOCD1MIR22 /// MIR22HGCRKC6orf120 CRTC1SLC22A9 UFSP2C14orf142 ZNF121IL23A /// TCRBV6S2A1N1TMLF1PTGES3L PRAG1TMEM241 CYBBLOC102724880MAP2K6LINC00276 DUSP22CYP46A1 LOC100129046GCGR SNAPC2EID2 LEF1GLIS3 ANKS1AEEF1B2 /// SNORA41CAPRIN2ALPP BCL7CRRP9 LINC01560STON1 PSMG1USE1 NDUFA4L2LOC101930608 /// LOC102723581SLC20A2RNF5 /// RNF5P1CBWD6METTL7B NFAT5NADSYN1 KALRNDGCR11 LOC105373159LARGE SQOR

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BAAT NADKPTAR1 TRIT1TSHB CHKAOPA1 TNFRSF11APAFAH1B3 STXBP1LIG1 MFSD10RIC3 CSRNP2GADD45G CLTCL1OSBPL8 LOC105372480TRIP11 TTLL7SPHK1 ZFPM1TBC1D8 TCAF2LUZP1 ZEB2CLTC HTR1FRBCK1 PLSCR1PAXBP1 GYG1GNB3 ZNF865CSTF3 NOP16CORO1C MRM2NR2F2-AS1TESDNAJA1 LRRK2LOC100287221LGALS3BPEIF4E2 KCNQ3BAMBI LOC100130744AKR1C1 UBAC2S100A14 FEM1BSPTLC2 ASRGL1DDX11 /// DDX12P /// LOC642846WDR25LYPD6 LINS1ASNA1 SPRYD7PPP1R15B BCHELOC100506282ZNF284KIAA0556 ZDHHC1MIEF1 MTERF3ZDHHC21 WLSGPR3 ZNF66TMEFF2 TMED7-TICAM2ABHD11 CIARTCLDN14 STAG3L3COQ10B COPEIDI1 MYO1CLOC100505664RIIAD1FLRT3 FNIP1HYKK ZNF319MCU LRP10ADAMTS2 ZNF429HIST1H1A ADH5COX14 GALTLOC101930059 /// LOC102724250 /// NBPF1 /// NBPF11 /// NBPF15KIF19NECAP2 NTRK2

Page 331 of 781 Diabetes

SLC27A1 SNED1ANXA2P2 ISY1HLA-DQA1 /// HLA-DQA2 /// LOC100509457AGMATVASH1 ZNF586ADCY9 MERTKGJB3 RDXMAGI2-AS2GIPRHHEX SCN3ADCPS APPL1ITFG1 BIRC5CMYA5 PHTF1LOC101930075 /// PKD1SRRM5HDX SPINDOCPHF6 FAM111A-DTVAC14 ARHGEF17CDC6 OPRM1RP11-454F8.2TMEM81GPLD1 LINC01011OASL LOC100506885RAI14 SLC4A4KRT23 PLPBPNXF1 FCMRKB-431C1.5AKAP11CDC42EP2 LOC100128288FOPNL CTNSBC037214 /// RP11-58G13.1JAKMIP1MMP19 DUSP7ANKAR CFAP46CARKD METTL8CCDC43 MID2RNGTT NEDD9RP11-33O4.1CTBSLOC728073PLEKHO1KIAA1614-AS1DMDMAPKAPK5ELK3C2orf68 SLC2A10SEMA6C PPA1PCDHB15 PEA15MAP2K1 RP9RP4-740C4.7GIMAP6RAB3B ZNF252PTAF5L KDELR1GCKR ACSS2UPP1 CYSLTR2LOC647070ALBAK311120 /// LSAMPFOXK1TMEM141 SULT1A3KIAA2018 SULT1A4C19orf70 DPP6CHPT1 VTCN1

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LOC101927907PHF24NUDT3 /// RPS10-NUDT3WDR44KMT2B NIPAL3ACOT1 /// ACOT2FAM78ASDPR DBPG2E3 TSC2TAF13 BCO1IGHG1 /// IGHG2 /// IGHM /// IGHV4-31 /// MIR8071-1 /// MIR8071-2SLAMF8DICER1-AS1BDH2SLC35F5 SEH1LING4 HSD17B14MACROD2 C5orf49ZBTB48 ATE1LOC100505874C6orf47FRG1 /// FRG1B /// LOC100134091 /// LOC100289097 /// LOC101930278 /// LOC101930531 /// LOC102724923GPRASP1ZBTB11-AS1UBAP1LFBXO31 LOC440895FAM214A USP47GET4 /// SUN1NOTCH2NLBNUDT14 RALGPS1DKFZP761C1711ZFC3H1VPS45 DBTLINC00894 HACD3MCTP2 CXorf56NCSTN HECASERBP1 SPDYE16RP3-508I15.21SMPD3RP11-727A23.11CBY1ZNF557 MTMR9RPL17 /// RPL17-C18orf32 /// SNORD58A /// SNORD58B /// SNORD58CRARRES2NPC1L1 GCNT3MOCS3 CENPFPRPF40B PHGDHC1QTNF3 LOH12CR2CLHC1 RAB25MAP2K4 PRKAG2TIMM50 FMO1NEO1 ZNF385AIL11 KBTBD3LIF CES4AMRPL3 THOC7SETD7 XPO7EVX1 DCLRE1BATG2B HIKESHIEMC6 ARMH1RASA1 HCN4CTD-2124B8.2C7orf25OSGEP HABP2STOML2 LOC644634AC092192.1NMI

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COA6 TRAF7S100A2 SP1LRRC58 MTREXRP11-248J18.3GPAA1LOC100132352COQ9RHOT2 RBMS2MTCL1 SHROOM4MOCOS SDSLVAC14-AS1ARHGEF11GPR173 EEF1B2LOC101930114LOC145783KIAA1143 SPTSSAMBD2 PIGVZNF518A HAGHMZF1 CACNG5RP11-339A11.2EMC7SGMS2 FBXL19-AS1CEP85L PLCD3MRPL34 EIF3ITBC1D10C FAM241BSLC25A27 WFS1PMS2L2 VSIG10CENPU C5orf63MNX1 THSD4LINC00674 UBE2Q2HYPK /// MIR1282 /// SERF2 /// SERF2-C15ORF63PSPNGUSBP4 /// LOC100653061GJA1CD6 POTEICD276 FYTTD1YWHAH CCDC32KLHDC1 NORADRPS17 LARP1MTFR1 TNFSF4SLC25A40 TOLLIP-AS1LAMA3 CTSATSPAN5 SPI1ANXA11 SLC16A12RSL24D1 SMPD2RBX1 MYO1EEXT1 C11orf52RAB27B PWWP3BUBXN7-AS1NASPRAB25 GNPDA1RBM34 OLFML3QTRT1 MRS2P2RPL5 /// SNORA66 /// SNORD21ZNF79ABCA8 ATP7BCSGALNACT1ALDH1A3MRPS35 TAF6AGBL3 METTL7B

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ATF1 ANKRD53ERP44 PSMB2RFNG C18orf32ZMYM2 METTL17TAX1BP1 AMFRUSP48 CCZ1PI3 EPHA4TUBGCP6 NSFL1CS100PBP PDCD6PARPBP PRR5LFEZ2 INKA1KRT80 PRPF4BCDHR2 SOWAHBLOC101929475HTR2BSCARNA15SNRNP35RND2 CHD4MORN1 BAG1SNX2 SLC19A3L3HYPDH RRP15GPRC5A CDC26LOC286437TBRG4SNTG1 TNFAIP6LOC100134317 /// LOC284412STAG3L1NIPA2 LOC101927178DMGDH VWA5B2WASH1 /// WASH2PWNT5BEIF3F NIPSNAP3ACACNA1A /// LOC100507353MRPL21INMT PRR34-AS1PRPF18 USP35ERVK13-1 ATF7IPSBF2 POLR2MEFCAB4A CNOT3WBP2 LMNTD1ENKD1 S1PR5FDXACB1 ARL2COPS5 SECTM1PSG11 /// PSG3TNRC6CVPS4A PEBP1SLC36A1 GCAZNF213-AS1SNPHFZD8 /// MIR4683DENND10P1DLX2 LRRTM2DQ597730 /// LRRC37A2ZNF490RP11-506O24.2RHOGCYTIP CIB1ARG1 AP2A1LOC283045LINC02495SLC25A3 GIMAP7RHEB CHM

Page 335 of 781 Diabetes

TAF1B MFAP1ITGA7 FRKMET NAT1ATP5J PRH1-PRR4RDH5 FRAT1HERC2 TMEM150AC20orf26 NDUFB8POTEM ILKAPTCEB2 NUDCCDK3 /// TEN1-CDK3KCNQ2LOC91548 FOXP1RIMS1 GAS6RGS20 THBS3GALT TBXAS1CDC45 IPCEF1CCDC127 ABCD4TTLL3 PAK2MTHFD1 PIPOXSLC7A11 MICAL2ZNF593 C1orf35ELMOD3 DYRK1APTGS2 RNF216P1CCDC78 CIB2NFX1 SLC25A5HSF4 PSMF1NKIRAS2 PLXNB2MAG KLHDC7BRAB6A /// RAB6C /// WTH3DIST14SNAPC3 COQ5KIF19 GPR37DYNC1I2 SYNDIG1IKZF1 HHIPL2KCNH6 RASSF2ITGB6 /// LOC100505984SURF2FBLN1 RGS5ND6 TUSC3MSH6 CCNQGAGE1 ZNF530MIR622 PGS1CLRN3 FOSL1EPOR /// RGL3RBFOX3GTF2F2 RNF19ALMAN2 ABHD17CITGB3 PYCR3IL1R2 ADGRE5AK3 CLDN2PEX12 COMMD3HNRNPU CCNJZBTB2 INS-IGF2DNM2 KLHL41

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ABCA7 ACOT1TMEM189 /// TMEM189-UBE2V1 /// UBE2V1GMIPP2RY1 DGCR9GATAD2A TMEM161ATGOLN2 DNMBPLEP JUPZFAND2A CTSSHSPA12A PTPN2MOB1A UBE2APPCDC TMC4RPL19 SMARCA1MYADM FUZFDX1 SOCS4A2M FCHSD1PDCD2 ZRSR2IFT172 PPP3CCRANGAP1 ZFP62EHMT1 C21orf62MAP3K12 USP21TIPIN RIPPLY3SYNM CPLX2MAB21L1 /// MIR548F5DNM3NUP93 C1orf21ARRDC2 PLEKHG1LSM8 RPL7L1RND1 SDHAP1CPNE1 FGD2SND1-IT1 SBK2FAM57A CNDP2PAM LAMP5FLJ45513 /// TAC4SPTBN4UGDH PLRG1GTPBP4 SONMARK1 LINC01750TMEM14B TNIP2POMT2 LINC-PINTCHMP1B CSTBTP53BP2 MKLN1RPS19BP1 DAD1ACKR1 LIN7BTMEM120BZCCHC2KCP SIRT2PIGG OVOL2USP20 FNBP1RELT ZNF471DHCR24 KMT2CVAMP8 C8orf44-SGK3AJ420595 /// GOPCBCL3IGFBP7 ZMIZ1IL2RG FABP5

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ZNF550 TWSG1GCFC2 RGS19CPT1C LOC101929243ASRGL1 UGT2B15DQ576994 RPS16RP11-498E2.7FAM49BRPL27A /// SNORA45ABATF2CST6 PTGR2DDX10 SSX2IPNKTR ZNF441PUS7 N4BP2L1DAB2 FHL5SNRNP200 ITPRIPLRRIQ1 RABGGTAPSMG2 FGF14-AS2TAB2 FEZ1MIR6513 /// TMBIM1CYP20A1BRD8 TPRNLRRFIP2 WDR91PARP4 LOC101930071ZNF277 EXOC7TMEM145 SPACA9TMEM18 GLS2KIF1C HSPA4ATP5B PIGKKRT19 LONRF3ZNF264 CDH18BC041347 /// FLNB-AS1 /// FLNB-AS1TRAF3IP1WDR16 EFNB1CLCA4 BHLHE40-AS1FBXO15 MEMO1LOC101926913FMNL1C2orf27A SUN2SBF1 ZNF273CHDC2 OSBPL1AL3MBTL1 MEG9KRT6B SMIM32LINC01013 SRD5A3PCGF1 IAH1GALE CLPTM1KLHL18 NESFAM175A MLIPSLC25A43 TMEM127ZW10 MRPS30RNF139 NR2C2APFIBP ANP32CPTHLH SPATA18C3orf67 MAP3K2ATOX1 LOC143666FOXE1 ZBTB24

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ATAT1 ZNF20ADPRHL2 KIF5CTMEM120ADDX60MYH9 DCXRCOPS8 SMAP2MTHFSD CDK1APOM MCOLN3AP2S1 FCGRTDNAH7 PEF1OR7E47P LOC389765HSH2D EMID1LOC101929757NT5DC2LRIG2 LGALS8LOC100289230EFHC2USP5 ZNF544ARL9 C3orf35LOC646214EIF2DLST1 SNORD140BAIAP3 KCNJ11WARS PLAGL2E2F7 METTL23FUT4 FSTLINC01207 GPR142GAN MAP2K3ABCC4 LOC401261RPARP-AS1PIM2BAALCOS ATP6V1E1MITD1 LOC101929767CYMP PEG13LOC221272ORMDL2DBF4 TOR1AIP1RECQL LOC100129540RP11-95O2.1GPD2C14orf1 GEMIN6HIST1H2BJ MROH7NFKBIB ANKEF1GVINP1 ZNF665FLNB SFTPA1GRIK2 GATBMIR4691 /// MIR7113 /// NDUFS8C19orf12FANCG MMP2SH3TC1 MARCKSGSKIP MED27TMEM144 DMTF1UBAP1 RNF144AKNTC1 DCP1BASPDH TINF2DDB1 CATGCSH /// LOC101060817FAM207AKAT2A GPR108

Page 339 of 781 Diabetes

THAP1 TTLAX747652 ABHD14BPTPRCAP GALNT18HABP4 REG1BHS3ST1 TNRC18SSNA1 ST8SIA5RP11-158G18.1PMEPA1LOC102723954PKNOX1CD68 /// LOC101928634 /// SNORA67CD8AS100A6 SHROOM3FRMD5 FCHSD2SLC35A1 NOMO2RP4-781K5.2POLDIP3LECT1 GNG7UCA1 LENG9KLF5 RERGPSMB10 DLSTKDM4C DNAL4PRSS30P ANKS4BCOL14A1 DPYSL4STAU1 BAATRBM19 RILPLOC150776 /// SMPD4RRN3P3WDR86-AS1AFF4UCN2 TRPV4MSH2 ESRRGBC052578 /// RP11-398G24.2CKS1BPARVA GPLD1LOC101928623 /// LOC401320COPS5HN1 CA12ETFA EMP1SLC25A23 LATS1LINC01000 /// LINC01001 /// LINC01002 /// LOC100132062 /// LOC100133182 /// LOC100133331 /// LOC101929819 /// LOC729737LINC00899PHF23 LINC00951TRAC TRMUZNF862 LINC01554NEURL3 PPCSPIEZO2 SYTL1SEMA3G NMD3P2RX5 HLA-FAGTR2 PCDHGA1SPARCL1 ELMO2ASH1L ZNF197MISP NDUFA13GNAL PPIL3IBTK HIST2H2AA3NAV2-IT1 HIST2H2AA4GOLT1B CHCHD6PSENEN DKK3CTD-2537I9.5SNAPC5

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DCXR KRT8ADAM9 PTGDR2SOX4 ATRXMETTL7A AGFG1RAET1E WDR83OSCOX4I1 CES3CTSO CRTAPMETTL13 LOC102724814FAM47A PDIK1LBICD2 CCND3LAP3 FSCN1CSNK1G3 NOVA2RP5-1074L1.4RRAGCUTP14A TRAPPC2LZNF582 CEP128NR1H2 DUOX2LYPLA1 STRIP1RP11-629O1.2CAMKK2YBX1 TINAGL1SAP30 LINC00662GPR115 ZKSCAN3TIMM9 FAM193AGRB10 ZNF106TSPAN2 FLRT1STK11 MICAL1TNFRSF1B STXBP5-AS1AURKA CHD2HIATL2 LGALS3YDJC RBBP7TPRXL SOCS2FAM226A /// FAM226BLOC105375690RPS17P5 /// RPS17P5TAF11ASNS ZNF681ZNF473 LOC388282CEBPZ HSPBAP1KCNK10 EMC2LOC644135XRRA1CEP76 PDZD2NPFF NYNRINGJB1 HERC1LINC01189 /// LOC101927827ATG7SDHA SDHAP2ASUN SLC22A23LOC389765MESTIT1MEIS3 WDR78KDELC1 CATSPER3PDZD8 MIR762HGRP11-433A10.3GPATCH2SRRD YARS2MARS /// MIR6758NXPH3

Page 341 of 781 Diabetes

GNB1 RUBCNGINS1 ST3GAL3TNFRSF14 IFNGR2DNM1P41 ZNF628NPW TFPIIDE ITGA3VNN1 INARAN ADOCOMMD8 GDF6FAM107A PLSCR3PCBP4 WDYHV1FYB TRAPPC13FAM13C ZNF461ABHD16A MOAP1MLNR TCHPHKR1 OS9HNRNPA1 MIPOL1MYEOV GINS1ZNF606 CEP44LAD1 NSUN5ALG1 /// NAGPA-AS1VTI1BGOLT1A PCGF2YBEY SHISAL2BZNF2 WDR97LOC101929480MAST3YPEL4 EXD3LOC153546CCDC43IL12A DEKNUDT9 GALNT1IMPG2 RPS13ASPHD2 FIGNL1ZNF418 PIWIL2RP11-190A12.8LOC101927377LINC00115 EBPNAMPT EP300-AS1FCHSD1 FAAP100PHLDA2 LOC100507053PDLIM5 HENMT1HDGFRP2 LOC101929599RP11-5C23.2SGCACRABP2 MARS2MIR7109 /// PISDLRRTM1NME9 EGFEM1PCDC16 FAM171A1MTERF1 BTDHCP5B HNF1A-AS1CHKB BCL2L13STYXL1 ABCC5DAB2IP SIVA1CXCL3 METTL9

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ZSCAN30 HDGFL2MFSD5 NCMAP-DTSRSF11 EID1RAB32 ADAMTSL2TPM3 ACCSFEM1B ARHGAP33SGK223 LMTK3DCTN1 HLA-DRB5ACACB E2F1TMEM86B AFDN-DTGTF2H5 TONSLLOC100130741SPDL1POFUT2 KCNE4RP11-394I13.2ERBB3TMUB2 SLC16A5KIAA0141 HIGD1AZNF780A ZBTB6CRK FLI1SPDYE1 /// SPDYE2 /// SPDYE2B /// SPDYE5 /// SPDYE6ADPGKGNPDA1 ANXA11TAZ FAM120AMOXD1 ANKLE1SORCS2 ATP10BH1F0 ADAMTS10COA4 SLC35A5ENTPD1 RLFESRRA RAMP2HMGB3P1 P2RX4LRRC48 PEAK1LOC101930052 /// LOC102724562 /// MST1 /// MST1L /// MST1P2ADAM23FAM83G MAFKTTN-AS1 PDE5ARPL23AP32NKD1PLEKHM2 FAHD1WDR59 THY1AK021804 CPS1EGFL8 /// PPT2 /// PPT2-EGFL8CELF4ANGPTL7 MRFAP1L1FERMT2 SEC14L5CPA3 CNPY2KLK10 FAM32AARMC2-AS1 /// ATP5J2BLMHPPM1K WDR26RNF123 RAP1AFLJ30403 NPIPA2ELK2AP STK16DDR2 TJP3ZGRF1 AGBL2TOP1 STARD7HRAS TNFSF15

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NACA2 RAB3IL1CSNK1A1 CAPZA1PITX1 VPS4ABC040646 /// RP11-732A21.2CNPY4SMAD2 MACC1SEPHS2 CRATTGFB2 ZNF282BC042374 CSF2RBLRP5 RREB1GPKOW HIP1CDK5R2 LRMDAITGA2 RWDD2BZFAND3 HOMER2IGKV1-37 /// IGKV1-37 /// IGKV1D-37 /// IGKV1D-37HMG20BNPPC CCDC120LOC101930097RPS5METTL17 NDST2BCL2L15 C14orf119GGPS1 HCKGIGYF2 ST7LVCP PRKACAFBXW12 LIMD1-AS1BAG4 UNC5BHDAC4 HAUS7LENG9 WIPF2BRI3BP LUC7L2MIDN ASPDHZNF835 ZNF326COPS2 BCAS4COPE SNX7PHB CBLN4ATL3 KIF12RRN3P1 LTB4RPKD2 AARDRIPK2 ERCC6L2FRK PPCDCTEP1 HGH1PLAU FUCA1OST4 ZNF703DENND2A PLIN5LOC100506289KLF2GADD45A FZD10MYO6 UFL1C17orf70 BEND3P3FAN1 DMPKUPK1B CFAP99WDR36 ZFHX4CTA-246H3.12PLCE1MPZL3 DCAF4PMCH TCTA

Page 344 of 781Diabetes

ASCL2 CSGALNACT2ING5 EPN3TRAF6 AGAP11COX7A2 GLCEZNF83 KIAA0100EBLN3 RHBDL2SEMA4D NEK6DYNC1LI1 ALOX5FLJ45513 ATP6V1HAK093256 /// RP3-486I3.7LRRC8AWDR87 NUP133MMD2 PEX5COX10-AS1 /// LOC100506974USP34PES1 CACNA1CCUL9 TRIP10MMP14 ZFP36L1ZNF836 SCYL3CHD5 RBM45RP11-486G15.2UVSSASNORD8 ARRDC4TPTE2P5 DYRK1BHOMEZ CHMP1BUPF3A UNKYKT6 MAST4-AS1IFT27 ETV4EIF2B2 TESMINGOLGA8A /// GOLGA8B /// LOC101930583MSL2TRNT1 SRRM1NUP205 KLHDC7ACLDN6 LOC653080GOLGA8CP /// GOLGA8DP /// GOLGA8EP /// GOLGA8F /// GOLGA8GAOC3TMEM200BCYP4F3PLXNB1 LUZP6RHOXF1 MTPNDLG3-AS1 RTL8AGNG5 RPL22RTN3 ZNF286BPUS7L SMARCD2BMF IMPDH2LOC102724200 /// TRAPPC10LOXL2KIAA1919 PKD1P4-NPIPA8ETFB PDZD4SGK494 RNFT1-DTRP11-38P22.2MYCBPPTPRO EPHX2SEC24B-AS1DNAJC8FBXO41 /// LOC101927826PLATRNF126 POLR3KGRIA3 MASP2TNFSF8 SOX9

Page 345 of 781 Diabetes

HSPB8 ACAD10NIP7 MORC3RBM4B CDH22MTA1 PIGBIDI2-AS1 SLC17A4TATDN1 JPT1LOC284513PP2D1FEM1A NRG3HSD17B10 TLE4LOC100507507DPP4DDX11 ZNF778RRAD LRP4SPIDR C6TUB C1SN4BP2L2 KIAA0895LFHAD1 MOSPD3HTATSF1 HSPA2SLC25A18 LACC1KIF12 N4BP1GTPBP10 /// LOC101927446CTPS1SYNJ2 FLAD1PRKCZ PPFIA3MAD2L1 IFIT2ARPC1B PLPPR5URM1 ALADEIF4G1 PRKXP1TMEM200CAMMECR1TMIE HABP4LYPD6B ATMINCES4A LINC01144COL4A3 HYIMAPK8IP3 RAB39AHIAT1 MRPL11RAB11A CCND1LOC100996693 /// SPEGACTR6OPN3 S1PR2DCDC2 SMIM12DDX26B MDM2TMC5 GPRIN3ANXA2 ZNF433AP000525.9LOC101927157ANAPC10 MLPHB4GALT5 CEP78SZT2 P2RX6SCML4 GTF3C3WHAMM SETD2TM9SF1 LINC01569ERI1 PARD3BCCR2 SLC4A7CTNNBL1 ACVR2A

Page 346 of 781Diabetes

GNRH1 NFASCCAPN8 SDF2DAP ADAM15SERINC3 LOC100294145PAN3-AS1 NOXA1MRPL49 DOP1BHSPA12B PTTG1CEP164 CYP4F12LDB2 ADNPPAFAH2 PRMT7SPRYD4 LOC100996419METAP2 LOC100506098BC065766 /// MALSU1SBK1P2RX7 FHITREEP1 LSM1MSTN PCNTSYNGAP1 LOC100505501HLA-DRB1 /// HLA-DRB1RAB42TRIM25 HAS3ARMC2 LINC00847WDR52 LOC100132249WDR1 PROX1FCF1 RRNAD1GPD2 ANKRD52MRPL33 PID1SH2B1 C7orf50DUOX2 ZNF513VDAC1 SCYL2DIMT1 CLCN7BCL2L2-PABPN1 /// PABPN1RNF39LOC100130458FBXO17LRRC14 CAVIN3LOC102724316KMT2BMPZ WRNIP1ZBTB42 HHIPL1LOC101929857 /// SLX1A-SULT1A3 /// SLX1B-SULT1A4 /// SULT1A3 /// SULT1A4CBWD3RAB29 MTUS2ISG20 AP4B1-AS1ARMC6 ADAM8TTC8 LOC202181BDNF ITGA11NACAD BASP1NICN1 RBM34CHCHD3 PHLDA2POLL MOB4TRIM7 USP18LOC102723600 /// MIR1302-10 /// MIR1302-11 /// MIR1302-2 /// MIR1302-9TENT2HMGCS1 MAGOH2PLOC100507468PPP2R2CEPHA10 ARRDC3

Page 347 of 781 Diabetes

ATP5D PPT2ZNF224 KATNAL2ARSI FBXL8DYNLRB1 NENFLOC642852ZNF101TREH IFNAR2TAAR8 LARP4C21orf62 SLC46A1KRT18P44 /// KRT18P44PGM5KIR2DS4 SLC2A1MB ZNF217CTAGE4 /// CTAGE8 /// CTAGE9MRPL20GTF3C6 KLC3GRB2 GBP1TTC17 FNDC5ATF6B EDEM2LOC101060181 /// LOC101928574 /// ZNF44ABHD14AZNF782 KCTD15ASTN1 FAM66BLL22NC03-N27C7.1 /// ZNF70UNC93B1KIAA0319L IDI1CEP162 SRP9ZNF92 UQCRC2BCO2 CCDC7CYP2U1 PPWD1C12orf45 HUNKGHITM CD6DRG2 HIF1ANARHGEF17 SLC10A5KLKB1 DERPCDRICH1 PIAS2PCTP PHLDA1ITPRIPL2 SGPP1SLC26A8 HNMTSMIM20 CCDC57TDRG1 BARX1PQBP1 USP19LRIF1 PYCARDSEPT7P2 CDC42BPAPQLC3 SERPINI1RP11-112J3.16ACTG1P4EBLN2 SHFMTMR11 IL1BIL1RN MPV17L2GCM1 GNAI1DEPDC4 ADH6ACOT9 CLEC11ADERL3 KCNA5KIFC2 ATXN7RPL36 MRPS12

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NUDT11 PINK1-ASAC008746.12STOX2APC BMS1P2-AGAP9ABHD14A /// ACY1ARL13BSGK2 EIF3LPHF1 TTBK1FGD1 NCK1-DTLOC283038PLCL2CA3 UROSSNAI2 ZNF609GIMAP7 GLIS3ITGAX HECTD2TFAM STAMBPATG14 RFPL3SAMMECR1 CPT1BRP4-581F12.1KANSL3CAAP1 ACTR8OTUD7B CEMIP2UNC5D REEP3D2HGDH SLC46A3CXCL12 C9orf78LOC101929328NIT2RP11-389C8.3IFT27SLC2A6 ENPEPCIT /// MIR1178AJAP1SCARB2 SGMS1-AS1PUS3 TATDN1SELO DUSP1SCFD2 EXOSC6UFSP1 VTA1DLST SIRPARNF146 MAT1AZNF160 LOC101927751BCAM LINC00511ARSA RIF1LOC101927451TMEM222PPP1R14D GSDMDLOC100131508HAS2POLR2F SOGA1FAM47C B3GNT3ANP32B ACOT8EPB41 SPAG5SH3BGRL3 IGSF21H3F3A /// H3F3B /// MIR4738EXOC3UGCG ARHGEF38B3GAT1 RTP4CLDN4 ETV7TAF8 EPOPHP /// HPR REEP2CATSPERB GGT6

Page 349 of 781 Diabetes

MRPL12 KIF9DDX11L2 LOC100132813CHD1L KIF3CEMILIN3 LMNB1CASP6 ARHGEF25OGN FHOD1RP11-248J18.2CAND1SOCS7 CTAGE6LRRC8A TRIM65GUSBP1 /// GUSBP4STMN3ITSN2 LMBR1ID2 HSD17B11BCCIP LOC112267983SERTAD2 BRD3TUSC2 TSPAN15IFNE GLB1L2RELB MGALOC284865CDK5R1HMMR ALKBH4LRPPRC ZNF808RP11-258C19.7TMEM107LRRC8E NEIL1PPIEL ZNF512BFAM188B /// INMT /// INMT-FAM188BSSH2LOC102725383PLPP7ZNF334 NSG1LGALS4 GAP43ELK1 RAPGEF4FAM84A TCF25PDZK1IP1 BLMRUNX1-IT1 HERC5VMA21 VCANSNHG16 /// SNORD1A /// SNORD1CPLEKHG6ORC2 ETFBRP11-216L13.19ZNF107LOC100507487 /// LOC101927184CYC1MMP3 MAP3K12OXTR SERINC1TMEM43 CYTORCOX7BP1 /// COX7BP1PIK3CATGFA BIVMNDUFAF3 PTPRZ1KCNK13 AZIN1HINT2 SWT1ZNF256 TBC1D9BGARNL3 ARID1ASTAT5B ARL4DMRPL17 EVI5LSERPINE1 FBXO28TNFAIP6 XRN2

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ERCC1 GGT5SH3PXD2A LINC00537LOC101927719HTRA2LYAR RCL1LRR1 LHFPL4VSTM2A GOLGA8JDTWD1 GCNT1RAB6A /// WTH3DIPAUPARELAC2 ZFAND5MAMDC2-AS1TMEM230FDPS CASP9HOMER2 SYTL2PSMD10 ZNF890PCBX1 LTA4HSTXBP2 NCBP2AS2TBRG1 TMEM246RP11-95H11.1COPS8FAM220A IFI6IL23A GDF15RP11-91I8.1BNC2DDX19A /// DDX19BALKBH6GRIA2 GK3PTNFSF15 GRSF1RP11-285J16.1TPI1P2NME3 NEAT1LINC01091 CYP2U1DTL ADAM1ARP3-525N10.2STK32BNUDT22 CHAMP1MED10 COX14CASC15 FABP4USP40 SEMA4DABCC6 /// ABCC6P1 /// ABCC6P2 /// LOC101930322GLIDRARFGAP1 INO80EPKLR GPR161SRSF4 N4BP2L2ANAPC4 NDUFA6SLMAP ZNF160ZBBX PPIFTAF12 AURKAP1WBSCR22 MTMR7RHPN2 H1FXRP3-334F4.1DEPTORRFC2 EPN1C4BPB TMED8LOC439994 /// LOC642361SUMF1TMEM163 ENOSF1ARL4A PGGHGCOL21A1 NUDT16L1SCARNA13 /// SNHG10VWA3B

Page 351 of 781 Diabetes

IL17C FAM90A1RPP21 /// TRIM39 /// TRIM39-RPP21EPHA1PDAP1 TMEM38BDDIAS CHD6RP1-78O14.1DNM1BOLA2 /// SMG1P2 /// SMG1P5TECTATSC1 CYP3A5BVES SYT12RP11-295P9.12UBTD2ADARB2 FXYD2EPRS ZNF318ZNF211 TMEM147TNFAIP3 CDK2COPS6 SLC35E4VCPIP1 CCDC173LOC283861L2HGDHNBPF8 ARHGEF9IGDCC3 EXOGANKRD44 CPNE3F13A1 GREM2ALDOB PHC3NPM1 TRIM44C2orf80 TIGD3ANAPC13 KLF8C16orf89 SLF2UBAC2 HSD17B2LRPAP1 MED18RP3-368A4.6FAM81AHLA-DPA1 FBXO44TLR5 DUSP15NGFRAP1 AQP1ZNF672 RBM15BCDC25A KIFAP3TFAP2C LIN9PLXNA2 DEF8LOC100506098LGALS2AMDHD1 PCDHGA7LOC101927206SLC7A5FGF13 FUBP1SPPL2A MYH3ACAD10 PRSS53TCAIM PCYT1BCTXN2 /// SLC24A5SMARCAD1RAD23B PCBP2-OT1ATR CLPTM1LPCNT PACSIN1GALK2 IFI44RCCD1 AMIGO3DUOXA1 RIC8BCHRNA9 NTAN1

Page 352 of 781Diabetes

SMAP2 OGDHLADH1C ZNF768FUT2 MYH9DPY19L1 PUDPTSLP PCYT2INHA NPSR1-AS1MANBA ADSS2SPATS2 ATPSCKMTREST FRYLTMEM14A PTP4A1MND1 CD24LAT PCED1AREPIN1 MSL1SSBP4 DUS1LHES5 ZNHIT1ADCY4 CLDN3FAM78A /// LOC101927137SERPINA3AAAS CDH6CYB5B TNFRSF1BRELA S100A11LOC101928230MCM3AP-AS1ZXDB ZNF423RFT1 TTC39CN4BP2L2-IT2TTC21BCAPRIN2 PCDHGA4TRMT10B PSG4COTL1 MYBPHLCOBLL1 RRBP1KDM8 TMA16ZNF311 NFATC2IPSIX6 FOXM1UBE2G1 ACTR10LOC100996717 /// LOC100996763 /// LOC101929796 /// NOTCH2 /// NOTCH2NLFAM122BRBAK COA3LMF2 ZNF436TLCD1 HNRNPA2B1KRT73 CEP63AC005785.2PPP2CBVENTX EXOSC8RPL15 ELOF1DSC2 WFIKKN1RP4-710M16.1CCDC18-AS1HCG27 TUT7NAPSA NBPF9UBE2Z CPED1FAM92A1 PPP1R9ALINC00629 HOXB6GLIS3-AS1 UIMC1SLC25A14 ENPP2NEBL LINC02532

Page 353 of 781 Diabetes

CIB3 ARHGEF2GTF2A2 GATA2-AS1PON3 CHD1LRBPJL FPGTSYT16 HLA-DMATFF3 LINC00997GOLGA2P7 /// LOC101929479 /// LOC642423 /// LOC727751 /// LOC80154LOC100268168NMB LDLRAD1SGSM3 EAF1CHD1 EN2OR2L13 ERC1RPP14 KCTD7N4BP3 KRT23PA2G4 CFAP57LIN9 UNC80IL13RA1 ICAM3SLC5A4 ASPSCR1MUC20 UBE2SAC007255.8 /// BC038570ZC3H18-AS1TFPT ZNF467TMEM54 C17orf53LINC00893 MIR99AHGRP11-1078H9.6ARMCX2GTF2IRD2 SLC25A6DAPP1 BOLA1ANKHD1 /// ANKHD1-EIF4EBP3POTEMTHAP11 ELOVL2EPHA2 PGBD1AK054988 TRPM7SEMA7A PRDX5FCER1A TMEM176BCDC42SE1 OPA1GATS IPWETV3 CHN1SWI5 FLJ46875CAHM CFAP70LOC100506639PCM1TCF4 SPOCK1RP11-109D24.1TP53RKZNF404 KCNF1PAOX DENND1CFGD6 SNCAMTAP MID1IP1DCAF15 TMEM256SREK1 MRPL32MFN2 CNNM4LOC100996643 /// LOC101928195 /// MTHFD1LTANKDMXL2 LMNASEC31B PCDHGA10TDRD10 CCT4

Page 354 of 781Diabetes

CXCR6 ZNF502ZNF91 NOA1PEX1 BEX4MCM4 RBBP4NEMF CA5BP1-CA5BDDX55 HOXB9APOBEC3F PMS2P1C1orf162 MAPKBP1ATP6V1E2 ZFP30IFI30 /// PIK3R2MRPL4NME6 KLHL26FNDC3B /// LOC101928615CTDSPL2C6orf211 TECRLOC402160ZNF785ZNF644 LINC01431HSD17B1 LRRC57IFT20 ZNF624L3MBTL4 MALT1HACL1 MVB12ARGPD3 /// RGPD4 /// RGPD5 /// RGPD6 /// RGPD8APLP2HMOX1 SPATA5L1DNAH6 FBXL2HLA-DRB4 KLHL17DNAJC5 ATP5MDFAM63A ASAH2BINO80B /// INO80B-WBP1 /// WBP1NSA2EYS D2HGDHGAPDH GALNSCDYL APBB2NXNL2 SRSF6CPPED1 CDK19SLC39A6 EYA2CREB3L4 SYNE1GSTP1 SLC14A1ABLIM3 ITGA9TPMT SNRNP27PRDM8 EXOC6POU4F1 CCL2SLC44A4 CYBRD1TBC1D9B ENHOPEX6 ZNF511PRO1082 LOC152048TIMM17A SMA4TIMM23B ZC3H12CRHOA WDR7ZNF335 MCATFMO3 LIMD2DNAJC1 PPIHRICTOR HEATR6SPRR1B HRAT92

Page 355 of 781 Diabetes

FBXO36 COLEC12ZMYND8 ACTA2CPM MAP3K15RHOF FAM234ALUM LINC00909RP1-8B22.1POTEELHFPL2 CTSLDAND5 RNF181NPC1 LIMS3-LOC440895MRPL24 PTPN6ANKRD13BTNFRSF10CFBXO34 DOT1LABHD17C SCN4BGPR62 FUNDC1SYAP1 BCAP31CYTL1 GABRECUL7 PLAUCXCL1 UGT2A3PHKA2 TMEM50ATRIM46 MRPS34GABRR1 CTSHLOC100128751NCKAP5LHMGA2 UBR3LOC101926959DKK4ACAP3 SYNCRIPCCDC64 TTC39A-AS1LINC01137 SLC29A2NALCN-AS1UBA3MST4 NDFIP2HERC1 RALYLMIR7111 /// RPL10ACTSKG0S2 USP7RPL23 /// SNORA21CLCA4-AS1ASIC1 SFRP2OR7E156P SLC27A1CR1L FAM210BLOC100507073SESN1HECTD2 CDC42EP2ATP9B LOC102724562TLDC1 PRTGDOCK7 IWS1FOSL1 NPHP1STARD5 ATRAIDATP6V1F /// LOC101927180CBR3-AS1GPX2 NFIBCNOT7 SUPT20HLSM1 NBPF26LOC153684MCM2IFITM1 SLC25A1ERCC8 CHST5

Page 356 of 781Diabetes

LOC101928020FRRS1FAU RGMBC1orf94 LOC440570ANGPTL2 ABLIM2RP11-416N2.4NDRG2LOC644794C4orf33SPG20OS SIAEPCDHB9 C17orf58HNRNPUL2 /// HNRNPUL2-BSCL2BCL2L10AF131215.8KHDRBS3WASIR1 /// WASIR1 /// WASIR2 /// WASIR2LINC02731FMO1 ZBED9GPI FOXO6CPSF7 CCDC189LOC101930657ADGRV1LOC100272216TRMT12FAM103A1KAT14EIF3J GTDC1KIAA1671 HEPACAM2COMMD5 /// LOC101928879 /// ZNF250ELOVL7ATP6V0C AGLWDR89 SLC45A1AKR1C3 TMLHEP2RX5 /// P2RX5-TAX1BP3 /// TAX1BP3POLDIP2UCP1 PPP2R2DPROX1-AS1NDUFB2MPP6 MAL2AF086288 /// RP11-768F21.1FBN1TMEM219 RORCZNF747 /// ZNF768UBXN2BCCDC59 GNL3LNUP210 COL16A1BNIPL /// C1orf56PLTPVAMP3 RTEL1RP11-37C7.3HELLSARMCX3 LOC101928907FCGBP SLC7A14PITPNM1 UBE2L6LOC100128108RAD51-AS1TEKT2 TMEM236CENPBD1P1PLEKHA2ARMC4 CRYZL2PPCDHB1 PDCD1SPACA6P LINC01273LOC102546294DNAJB6UBXN10 DCLK3N6AMT2 ZNF18IDNK DBNDD2DSN1 GPRIN2H3F3A H2BFXP

Page 357 of 781 Diabetes

CHRDL1 LOC100101478ATP6V1G1 LDHDUBTD2 CENPLLINC00610 DNAJA4UCHL5 MSCINTS10 SALL2KL UBASH3BARID4B FAM85AFGF12 FAM214AF2RL1 WNK4ZBED9 SLC16A11RP11-109M19.1IL6RSEH1L DLEU1BRSK1 DCXCRTC2 HIPK2NXT1 STAG3L2ZNF767P ZNF439CPQ CERT1RPL27AP /// RPL27APFBXL18COX5A RPS2P32TGFBI MEX3ACLCN6 FAM21EPATG4C HEY2AKR1C1 /// AKR1C2 /// LOC101930400BAIAP2SLC22A1 HDAC8FBLN5 PI4KAPF4 ZNF788PCADM2-AS1PAPPA2ATG13 EFNA1CYP2C8 TENM3PHF21A LOC114483834TUBE1 SLC30A2GIMAP4 ZBTB1SUGT1 ARSIRCC1 MEAF6LINC00284 HIST1H1CTPSAB1 RHOVLOC102724316 /// PTCHD3P1RUNX2C1orf204 CCDC198KRBA1 PLEKHG4ARL5A /// LOC101929356RNF139-AS1CNOT6 MOSPD1ERICH3 SMG1HBEGF OPA3TOM1 TOLLIPDEFB4A /// DEFB4BCDHR3LYRM2 LCATMIR29B2 /// MIR29CDENND2DSNX3 GDE1SNORD50A /// SNORD50BEEF2K

Page 358 of 781Diabetes

LOC101927668 /// MACC1PSG9CNNM3 SNRPD1CIITA ERFLTRIM14 AGO2C18orf32 /// RPL17 /// RPL17-C18orf32SP100FAM193A LINC01816MSMO1 ZNF440LAMTOR3 EVPLADAM29 /// LOC101928551SPC25PGM2L1 FAM200AZNF655 C2LOC101928687ACVR2BC15orf45 PGAP1RND3 ZNF767PLINC00667 PITRM1METTL25 TRNT1PPIL1 SAFBIFITM10 CLDN6CEP290 FAM160B1LSM5 CA9GSS NDUFAF3ABCA5 C1orf131SDR16C5 RNPC3LOC102724967MFSD3RP11-613M5.1IRX3BHLHE22 M6PRSHPK GSTZ1RP11-465B22.8GJA3TRUB2 TTC39BBTF3L4 AHCYL2TMEM214 CCDC87FAAH2 IRAK3MAN2C1 KLHL31PAQR3 EIF5BNEDD1 HSPG2PFDN2 TMEM18NXPE4 SAP30L-AS1MIR424 /// MIR503 /// MIR503HGTGOLN2ROR1-AS1 VCLUBE2N PCDH12PRR14 LATMSL1 ARHGAP32NANS UQCRHRP11-1L12.3UHRF1BP1CANT1 DPYDKIF11 PAXIP1-AS1ANKS1B TSPAN18MYL12A TFRCCORO1B THUMPD3TRIM54 MED24

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ADRBK2 ARSJMRPS15 TMEM238SRGN KCNB1ISX MRPS16SLC1A1 CD74EIF5B MIER1PRMT5 DAGLARP3-507I15.1SPINK1RAB14 MIOSC21orf67 SORD2PLOC100506248 /// LOC728026 /// MIR1244-1 /// MIR1244-2 /// MIR1244-3 /// PTMAZNF727CCDC11 SLC24A1SLC35E1 TCEANC2LOC103344931MINDY3NCAN KDM5ARFC3 DEGS2TNFAIP1 CUL7MAP1LC3BAAGABPLD3 PHF10ACOT7 ABCA1LOC102724537IL3RAARFGAP3 BUB1B-PAK6DDX54 ZNF185SH2D4A TGFB3CHD8 GBA2C2orf16 MRPS17RGS7BP VWA8RGS13 ZNF330C21orf58 TOGARAM2URB2 SH3YL1PYGO1 COA4HYMAI DNASE1L1RPSA /// RPSAP19 /// RPSAP58 /// RPSAP9 /// SNORA6 /// SNORA62EEF1AKMT1NABP2 GRAMD2ANKX3-1 NECAB2SGIP1 SERTM1DCAF8 CYB5R4BACE2 ZNF37BPKIN MAFG-DTLOC101928101EIF4EBP2DHRS3 A2M-AS1LOC101929336 /// RIF1ANKRD16SH3BP5-AS1NRG1HDAC8 DCLK1CC2D2B DHX29CRADD SLC5A1C19orf40 FDPSP2ACAD11 /// NPHP3 /// NPHP3-ACAD11DIP2BTNFSF13B SEPTIN9FBXL13 PSMD11

Page 360 of 781Diabetes

CD2AP CEP126PDCD6IP FAM20BCCL26 PREX1C4orf17 ZSCAN16UQCRH /// UQCRHLZDHHC8P1PFDN4 COL14A1PPP6R1 DGAT2ASPN MYEF2MMP7 FHAD1NUDT10 B3GNT7LOC101928100ONECUT1TOX4 PIGUMEX3D PLXNC1PHF20 RAB11FIP3PPP3CA SNHG21MICALL1 METTL21AHIST1H1C BRD7ERBB2IP CAMK2GPBX1 CCDC103MOB3C PCCAATP10B PDE8AZPR1 SSPOC1orf101 FAM83GARL8A SYNGR2PDLIM3 VILLFOXO6 TRPM2PTMA CLVS2CTTNBP2 DLG3NUP153 /// RP11-500C11.3RAB40ACDH10 C3orf38DHTKD1 LOC105376114PLIN4 DAXXAPOL5 ZNF276SFTA2 PSMG3-AS1RPL7AP10 /// RPL7AP10ZNF200COPS7A IPO5FAM104B BRD2CAT ATP2B1-AS1SERTAD1 PKN3ART3 ANGPTL1IFT88 DOCK7GRTP1-AS1 /// LOC101930007 /// LOC101930262DISC1RP11-111M22.4ECHS1TTC1 TCIRG1LINC00925 HUWE1LPL MED15GCNT3 CDKL3PDZD3 SURF1KDM6B HILPDAPRSS53 TSEN15

Page 361 of 781 Diabetes

ATP6V1G2 DPY19L2KIR3DL3 TEAD1ACTR2 METTL6ASCC3 TSPAN8BRAT1 SYT13RP11-250B2.3CCNJLZBTB34 COX15SLC30A6 DIXDC1ARIH2 KCND1PLEKHF2 LRRC36LOC100506834CPQRNASE4 A4GALTMGC70870PDLIM3SHANK3 FUT2NF2 IFFO2MURC ZNF700AF086126 /// C16orf52COA1ARHGEF33 NUP50LOC100131541WFDC2LECT2 LINC01139CLK4 SNRPD3LINC01279 ALX3WDR35 TCAIMPRIM1 AK6KLHL17 PSMB1DHCR7 ITGAXATP11A-AS1LDLRAP1PLIN1 ZNF883CNIH1 TAPBPLAKR1A1 PPP6R3SHB LYNTTC23L LOC100130691B3GNT3 AKR1C1LSM12 RASSF10ADORA2B APOL1PPP1R21 SLC38A5WAS HYAL1C3orf58 BMS1P4PSMD9 BTBD3RP3-522P13.2LRRC24KCNK3 FAM133AIKZF4 SKILCFLAR-AS1 CDC42BPGGDF15 ZNF625CKAP4 AKR1C3TRAK2 EEF1DOLFML3 SUGP1HLA-DRB1 /// HLA-DRB4 /// LOC100996809ZNF419HS3ST3A1 PPP4R2FCN1 NLK

Page 362 of 781Diabetes

LBX2-AS1 CCDC78RBP1 RALBGNG12 GAREM1YIPF5 ZNF239TYW5 PDE4DIPMIEF2 HDDC3XKR7 NUP42CYP1A2 TCEAL8ALDH4A1 DYNC1H1USP7 FBXO22SLC35F4 GMPSDIO3OS /// MIR1247LOC100130950RBM25 KMT2E-AS1TRIO FAM155APSMD5 PLEKHB1TMEM104 ZBTB8OSTNIP1 VPS9D1-AS1PEAK1 SMG1P6SUPT7L STK35KISS1 TMEM144TP73 SERPINA5NAPG SPATA6AP5B1 IDI2-AS1LOC101060321 /// LOC101060351 /// LOC101060376 /// LOC101060389 /// LOC102723859 /// LOC102724862 /// TBC1D3 /// TBC1D3C /// TBC1D3F /// TBC1D3HIL10RASRI CD83FAM122A MPHOSPH8C1orf106 RTCA-AS1RFX3 MPDU1NAPEPLD GPN3KPNA2 RAPGEF6CD59 WDR63IRX4 ATOX1PMCHL2 MICALCLOR7E14P CHAF1BCDC42BPG PPARGRPL39L ADAP2ADAT2 ITM2BMETAP1 BACE1ANGPTL1 CENPOFLJ45482 RNF6PALB2 UBXN2ACHMP2B FENDRRTFPI2 DHODHCDKN2B-AS1ZNF385DSRP72 MAP1BRNF168 TWNKJUP /// KRT17MED30KIF4A TULP4KCTD14 /// NDUFC2-KCTD14FAM135BCFL1 RFXAP

Page 363 of 781 Diabetes

PLGLB2 LINC01003RP11-255A11.4LINC02106RAB22A PROSER3CDRT4 /// TVP23C /// TVP23C-CDRT4KITLGARL17A /// ARL17B /// LOC100294341DNAJA1MDFIC TLDC2PLLP OBSCN-AS1LMBR1 LTBP1EPOR PIP4K2ATRIP13 C3orf33LOC100270804ESYT1DQ586822 CDR1PALM NIPBLUBE2H YBX1CTB-102L5.7NHSL1RPRD2 DNA2PLEKHA8P1HOXB4CEACAM7 FAM13ASLC27A3 TMEM60RP1-20C7.6CATSPERBS100A16 CUL1USP43 EFNA3LOC100289097 /// LOC642236PCDH20TPR GRHL1CD3E CALM1CACNA1I MAGEF1AGGF1 GAS5ZIM3 CSTF3CMPK1 TUBLOC101929622WNT3HHIP-AS1 CTSFGLRX5 CPAMD8PRPH ERICH3RPL13A /// RPL13AP5 /// SNORD32A /// SNORD33 /// SNORD34 /// SNORD35ACTDSP1PDCD4-AS1ZNF320STMN1 FAM83BFAM107B GPR39EDN1 CTSDPCF11 ARHGEF37PPARD AK9SETD1B IRF2JPH3 PRICKLE4PIK3R6 C4BPAJMJD1C-AS1DUSP19EXOC1 BAZ1ASSR2 SLC19A2RAPGEF4 LRP11FOXQ1 NAPGLOC101927137 /// SCLT1ZFATALKBH2 RTEL1-TNFRSF6B

Page 364 of 781Diabetes

LOC100507547 /// PRRT1PTGS1DUOXA2 DUOX1SDHD FAM47EC5orf51 IGSF9USP3-AS1 CCZ1P-OR7E38PSLC25A36 AFAP1MAP2K6 ANTXR2CDC40 FBLN7CTSG SLC24A3GBA2 OXCT2ACTB /// ACTG1BUD23TAPBP HMBOX1NDRG1 LITAFRPA4 HLA-VTFF2 NECTIN2SNAP29 PSMB6SLC26A2 SIDT2LINC00494 TMEM176AMVP MYO1FBC022892 NDUFA4CMTM4 PYCR2TMEM127 LAD1SNX14 C3orf80LPIN1 ADA2SLC25A32 NME1SLC35G2 GPR143RP1-193H18.2TBCACRTC1 SLC37A2ANKIB1 SERPINB2PKD1P1 SH3D21GLIPR1 CALCRLDZANK1 LIG4LINC01106 /// LINC01123HHATAP4E1 ZBTB7AC2orf42 MAPRE2CLTA UCNALKBH3-AS1SRGNHSPH1 CFBRITA1 BABAM2TOR2A COL1A2LOC101928111EPHB6ZYX CASP3KHDRBS1 LINC02389PWP1 ABCB1GANC COL4A5C5orf28 PDXDC2P-NPIPB14PCCL2 PSDZNF133 ZSCAN1FAM21C /// LOC101930591ELAC1ZKSCAN5 FEV

Page 365 of 781 Diabetes

S100A11 DHRS4-AS1RP11-171I2.4DENRCWF19L1 MBIPC9orf89 ERFC10orf107 ZNF573HIBADH EGR1AKIRIN2 DDX28PPAP2C PKHD1GTF2E2 NDUFA9CD58 CACNB2MOSPD1 PSMD14LOC101928278GOLGA6L4PACS2 KDM3BERI2 TLR1GBE1 SELENOMFAM66B /// FAM66C /// FAM66D /// LOC101928910 /// LOC102725108CYFIP1BOK DR1TUBA4B NMT2ZNF771 COMPLUZP6 /// MTPNPIGZFAM65B ZNF638HCN3 NRSN2-AS1GTF2H2 /// GTF2H2B /// GTF2H2C /// GTF2H2C_2YTHDF3-AS1TMEM125 RUNX1TMEM217 NICN1FABP6 EFNB2CDC20B NFIXTMEM19 SSTR1LOC100507054ZNF891PJA2 TMC6KIAA0753 METTL27KIAA1683 CAAP1PRPS1L1 PLBD2DKFZp564H213WAKMAR2BATF2 ZNF615RP11-288H12.4ADGRE2CUL2 ACAP2SH3PXD2B CHI3L1UBN1 ANLNSGCA WRB-SH3BGRSPRED1 WDR5TIGD4 SCAIB4GALT1 PAQR4BPIFC CDK8DRD2 CEBPDOLIG3 ZHX2RARB GJC1LINC00921 /// TIGD7 /// ZNF263FN1HYLS1 EYA3GFM2 AP5S1

Page 366 of 781Diabetes

ZNF101 TMCO6RP4-773N10.4ANKRD13DDHRS9 MPP7EDRF1 PANO1HS3ST2 ZNF251LINC00908 FAM156AATXN1 TSPAN7LOC101926918DBH-AS1AMT RTF1RCL1 NFIATESC BMP8BGPR114 PRKACBREM1 SPCS1TTF2 CHODLAATK SLC39A14LOC101928104AKAP6C16orf54 ARHGEF16SNX1 SLC27A2LOC101928626TAS2R5LASP1 GAS8KIAA1109 BDP1MNDA TMEM163ZNF518B PODNSNORA74ATENM4ST7-OT4 TMEM132BMEIS3P1 AKAP5NPPB STAU1GPC5 APPBP2UXT TBC1D17HSD11B1L GIGYF2FAM46B ZNF765LOC102724587SIL1MIR6875 /// TRIP6SAXO2LOC102724356EEFSECLINC00881 FBXO15C18orf54 AMHNLRP8 ZFPM2WDR6 FAXCCHCHD5 SLC49A3GTF2H1 JAG1MON2 SLX1AFBXO30 POLR2J3PLCH2 TDRD7ZWINT MSL3P1C1QB NMNAT3C1orf213 PHYHD1ATXN10 GRHPRGPR137C LINC01586LINC01085 FAM149B1ARL14 LRRC75A

Page 367 of 781 Diabetes

POLR2J2 FOXN3-AS1GYPC ANKFY1FDFT1 AP2B1GOT2 PTPRMZBTB39 SPON1EIF4A1 /// LOC101928634 /// SENP3-EIF4A1 /// SNORA48 /// SNORA67 /// SNORD10GTF2H3FNDC9 VWA5B1AP1M2 LRRC23CAPRIN1 UXS1SPDL1 TAF2MIR6732 /// ZC3H12APSMA6CLCF1 MRPL15LOC101927278AQP3LINC00700 MED23DTYMK PKP2GLP1R ENGASEGRIPAP1 ADCK5PPP6R2 TMEM63BGK LEAP2DERL2 KCTD8RARS2 SEPT5-GP1BBPRMT1 C1orf116EFNB3 UGT2B17WFDC1 DGKENUP62 NEK4BTBD9 PTPRAPAPSS2 JPH3SELL ZNF623MAP1B LINC01530PKIB TRIM8TXNL1 MRGBPCASC16 XPO1MAP3K3 ELK4SLC8A3 CNNM2HIST1H3I CPT1ACRYGD OLAHLRRC40 ZNF559ZNF24 EPHA8C12orf55 LRFN1LOC101926907AKR1B10KIAA0408 TCF7LOC101060391KIAA1107MIB1 LINC01089STAM-AS1 LRIT3LOC101927829GRINACRYBG3 PIAS4LOC439911TSPEARC16orf3 SIRT7PELP1 ALPK2METTL1 SMS

Page 368 of 781Diabetes

TMC8 FLVCR2LSM10 RGS16NDUFV2-AS1CCDC168CCDC12 FZD2DPP7 KCNJ15RMND5A FOXRED2KRT15 TMEM132ERP11-680C21.1MX2IFNA1 HIVEP2IQCF3 /// IQCF4WDR70NRAS MPP5MOK CHRDGPR162 TSPAN31DENND4C LOC100129034SEPT4 PARD3EIF5 CITED2C16orf93 MRI1TMED8 NTMT1PIDD1 TRABD2BITGB2 RNF10DPY19L3 FANCILOC101926906LLPHTSPAN8 ABCC3WDR74 CENPURABEPK RGL3EDNRA AHCYL1LOC646762LNPEPIGLL1 VAMP2ZNF28 ARHGAP27MGAT2 NUDT8CHEK2 ADORA1KIAA2013 SMC4ZMAT5 ADPRHL2LYPD1 PABPN1YES1 TNFAIP8L3HDAC1 ZFRGGT7 C18orf54TRIM47 P4HA1CT45A1 /// CT45A2 /// CT45A3 /// CT45A4 /// CT45A5 /// CT45A6 /// LOC101060211 /// LOC102723631 /// LOC102723680 /// LOC102723737GPC4RBMS1 PRR7NNT ZNF879F7 ZNF271PCXorf56 HEBP1KLHDC9 ARHGAP6EIF1 GRB7BCL9L FADS2HK2 /// RP11-259N19.1ZNF71UGT2B15 FILIP1LROR2 STSPAX5 EIF4E

Page 369 of 781 Diabetes

C12orf54 MEGF8RAP2B UBE2E4PSNRK-AS1 KDSRGOLIM4 AP3M1LOC101928553IRF5FA2H COLEC11PEX13 PSMB8-AS1FMR1 SHPRHPAPD4 LRRK1BRE WDR47FAM83B TPK1CDH24 HLA-DMBC3AR1 LINC01754MGC4859 FBLN2CAMK4 ERLIN1U2AF1 TPM3P9HBG1 /// HBG2EIF1B-AS1TMEM87B CC2D1ANEDD9 LOC101929188LOC80154 PEX16STX6 PRPF39CDKN2B FLRT2LANCL3 INSYN2AGNB2L1 /// SNORD95 /// SNORD96AUBE2R2SNN BCAP29LOC401052RARRES1HDDC2 GXYLT2EPN3 B3GAT1CCNG1 RGS1TCAP MTSS2ACTBP9 /// ACTBP9SPRR2ARPS12 KCNH3PAK2 ADSS1HADHB CROCCP2NPHP3 CBFA2T3UHRF2 IGFBP3GPR135 MED25CREB3 PPARGC1BAATF MSH5IGSF5 IER3TTC27 MGAT4CSTX7 BCL7BLONP1 ZNF358USMG5 MCM5EIF5A ZSWIM1TBCK ZNF676TTC38 RPS25HSFX1 /// HSFX2EPB41L4BPCSK2 PTGER3TNRC6A JAM3

Page 370 of 781Diabetes

CSMD3 FIS1RPP25 NEK5SAV1 FOXL1GABARAPL1 /// GABARAPL3NCKAP1LUBL7-AS1 MANSC1PALLD PCDHB9LOC100129722GJB2RP11-157P1.4CETN3TMEM67 HMMRLOC100506100SMARCAL1BAZ2B HINT3GCLM SCRIBMNT NPIPA3PITPNB FBLN5IWS1 DCNTPTEP1 KLHL36HAND1 ZNF250UCP2 LOC100310756OGFOD3 ENTPD3-AS1ITGA5 ZNF227BIRC3 SLC8A3AC005523.2AIFM1GRM5 AIMP1FOXL1 F13A1C1orf112 CLEC2DTXNDC15 PPFIA4TMEM51 SCRN1PACSIN1 ARHGAP11ALOC101928198 /// MFAP3LUPB1GUSBP5 FRMD6ACTB ENO2LOC101928789 /// SP140GUSBSLC22A3 COQ3KIF20B ALDH7A1ZDHHC8P1 LYSMD1DIS3L2 MAP7D3NLRP3 HBEGFCPVL KCNC3KDM5D EIF4A1WDR60 SLC25A29ATP6V1C2 SHMT1CTC-338M12.4RHBDF2PIGZ EPC2NMT1 ANO7STMN4 PHTF2ZCCHC10 UTP23TNFRSF11BSDC3MIR4680 /// PDCD4RPH3ACD8B /// LOC100996919GOLGA7BC2orf72 BCAR1

Page 371 of 781 Diabetes

INSL6 OSGIN1AXIN2 IER3-AS1KRBOX1 ILF3-DTDDX19A DCAF6TPSB2 TMEM59WIPF2 ANAPC4GJA9 /// GJA9-MYCBP /// MYCBPLOC102723665PTGER1 PROM2LY86 C17orf75RCAN1 FSD2SLC16A1 PRLRSLITRK1 CD34TRIM71 TPST2PPWD1 PCDHGA8LMOD1 ZNF835KIF26B ATP5F1BMPZL1 LTB4R2INPP5E ADAM20P1BTG2 SLC12A4HLA-DRB6 INHBAEGLN3 TMTC2MYOT CYP2C8APOBEC3B POLE2CNTNAP3 /// CNTNAP3B /// CNTNAP3P2SEPTIN3SRSF12 PIM1MSL2 ZC3H7ACPSF1 /// MIR1234 /// MIR6849 /// MIR939FLG-AS1TOMM40 APCSHMBS PDLIM7ND2 GRM6MIRLET7DHGEXOC5CALB1 HNRNPUL2-BSCL2LOC101929761HLFSLAMF6 PPIL2TBKBP1 GFM1COX6A1 CPXM1SCAF1 FNBP1LNAT1 TCF21CBLN3 SCAMP1-AS1TMEM2 NKX6-3KLC4 EIF6AURKAPS1 /// RAB3GAP2SLC22A4SEMA5B ZNF836MXD1 GAS1RP11-384P7.7EMC4SLC35E3 SFMBT1RASSF4 MAPK12KIAA1522 ASB16CDC42EP3 LOC100996724ZNF207 LRRIQ1

Page 372 of 781Diabetes

KIAA0907 RAMP1VPS52 HSD11B1LDHODH SSH1RP11-307O13.1TCF12EDF1 EP400P1ACAT1 GIN1NFU1 MED14SLCO2A1 CELF3ALG14 PHACTR1LOC100130357RYR2SLC35A4 PEX2PGK1 ZMPSTE24NMD3 CD58ZNF514 IFNLR1KCNK6 NIP7RP11-692P14.1RASGEF1ATMEM175 TACC3NLRC5 SCN8ASLC35F2 DPCDRBBP5 SEMA6CRASGRP3 S100A10LOC100505902 /// LOC285389RAD51CSEZ6L2 MAP2K5TMCO1 LOC100289561HKDC1 ARSGLOC101928927 /// SNHG15 /// SNORA9LYPD1IP6K2 DEFB1PDZD7 JCADBC017398 /// CTD-2314B22.3 /// DQ786293 /// DUXAP10 /// LL22NC03-N64E9.1ZNF793-AS1SLC17A2 NRSN2LINC00343 PTGES2-AS1AGPAT4-IT1SOWAHAMKS1 ANKRD28SNRPG CCBE1FBXO25 MT1LYIPF6 ADAM28LOC100996654RAP2CTMEM30B DNAJC4EGFR RRS1LOC93463 ATP10APLEKHO1 NADSYN1GLE1 MDFICOX7C NPM2ABCB1 CLDN9CLTCL1 TRIM16LSIRPB1 DACH1ZNF182 CTXN2IL32 NPDC1ZBTB47 PNNTCERG1L GPN1

Page 373 of 781 Diabetes

MIR6824 /// SLC26A6NOD2ASIC2 PAPLNTERF1 USP11MGAT5 CRPC3orf14 PTRHD1IL4R LY6EFAM13A-AS1TLR4SLC43A2 FAM13BLINC00665 NPIPA5SHISA7 RASAL3CPA4 ERCC6PSMB9 GUSBP1FCGR2A ZNF579FLJ43315 /// LOC101927088 /// LOC101927527 /// LOC101929518 /// LOC442028BRD3OSLILRB2 GPTTOM1L2 PARGSYNDIG1L UFSP1RP11-395I6.3TRIM25P2RX2 LOC100132356WDFY1 KXD1RANBP2 /// RGPD1 /// RGPD2 /// RGPD3 /// RGPD4 /// RGPD5 /// RGPD6 /// RGPD8INO80DLINC01021 RBMXL1ROMO1 PHF3FAM210B ZNRD1GJA5 SH3GL1P1LOC101927253KIAA1217SPRYD3 OSTM1SUGP2 ZNF592CAV2 CGREF1TRIM31 CCDC159ENTPD5 LYPD5RAD23A GLE1ZNF428 KIAA1841SEPW1 FOXO1DUXAP10 TSHZ1LDHC NUDT1AK022030 /// TROVE2WDR35AIF1L PVRIGE2F1 NPTXRLDHB ZNF146FAM120AOSPSMB5RIT2 ZNF616ANKRD2 MGPTMEM80 DRAP1FTH1P5 DISP2PRICKLE2-AS3WASH5PHMGCR HMCN1ITPR1-AS1 CRNKL1GPX8 CCDC39BCKDHB PPA2

Page 374 of 781Diabetes

ALDH1A2 /// LOC101928635ZNF557CTD-3092A11.2SRCAPHLA-DQB1 /// HLA-DRB1 /// HLA-DRB3 /// HLA-DRB4 /// LOC100996809 /// LOC101060835JPH1HABP2 HIST1H2BDHPCAL1 PRKD3HHIP MESP1FUS GOLT1AFGF19 CDK5R2CTD-2555O16.4 /// MTHFD1LIME1SHMT2 CCNFRHNO1 COPZ2ARL5B MTHFD1WBP1L GABBR1PARL EMILIN1SHCBP1 KIAA0586RP11-49K24.4RBBP6LOC102723918SLC1A5EMC2 MEI4DNAH12 NMNAT2ZNF821 RRAGAKANSL1 NAPEPLDRXRA ZNF876PTTC39C TBC1D3LBRCA1 NAXDGJB2 AUP1SETD3 STK11IPPDK3 PALM3CASP7 C9orf163KRT76 GDPD5KRT18P50 /// KRT18P50EPDR1LOC148709DTD2RETN ITGA7PCDH19 C9orf64DNAJB6 GBAP1MAP2 VPS37APLAC8 IL16FBLIM1 ZNF714SUPT20H FMN1TARP /// TRGC2 /// TRGV9SIM1RBM27 SLCO1A2GAB3 ATP2B2MAPK6 CERCAMIQCK LINC01465BHMT2 AP2M1CCRL2 HHLA2PTBP3 GPR119GALNT1 HOMER3GALNT4 /// POC1B-GALNT4ZNF699STK3 CLIP1DYNLL1-AS1SRSF4

Page 375 of 781 Diabetes

C14orf166 LOC101928595SSBP3-AS1 RALYIGSF3 HS3ST3A1OR3A1 HAAOPAQR5 CLN8CCDC104 GGCTRDH8 KHDRBS1DOCK2 EPB41L2DNHD1 CARS-AS1FOXN2 DCP2LOC153577TGFBIHSPA9 FAT2ORAI1 FSTL4NDUFA2 CASTOR1CHID1 LOC101927811LPIN2 CLN3SPATA6L PLOD1RP11-846E15.2IQSEC1RP11-66N11.7ZNF385BSNTG2 COL10A1PHF7 ST13KRR1 CRY2MS4A14 PDCL3P4GNPNAT1 KCMF1FLJ31306 ZNF512NOB1 HIST1H2ACDGCR14 ZNF175RP11-1277A3.1DMXL1LOC731424ZCWPW2GFPT1 ZBTB48ND3 /// SH3KBP1MARCHF1LAT2 PRICKLE1CDC42EP1 MAT2ARIN2 TRIM9LOC100127974NUAK2GLCCI1 CXCL5SMC1A MARCHF9PRKAR2A ZC4H2LIMK1 GAD1UNC80 SUN1NT5DC4 TMEM258SH3GLB1 RAP2AHLA-A THAP10CHCHD4 TBC1D2PLAA HMGCLSPTSSA LOC644936ABCB8 /// ASIC3RPUSD3MS4A6A C2CD4D-AS1PVRL1 RAP1BCTTNBP2NLRAI2

Page 376 of 781Diabetes

LOC100129361SLC41A1ALYREF TBC1D7-LOC100130357CYFIP2 SRD5A1PAN3 TMEM80RP11-18I14.11DPH5TP53I13 GCNACSNK2A1 /// NFE2L2POC1B-AS1GDAP1L1 HECTD1NLN SLC9A3-AS1MTPN LINC01315CCDC68 FGD5-AS1APEX2 GRAMD2BRRP1 THAP12DLD KIAA1522OGFOD2 KLC2NFE2L2 UBXN10LOC101928747 /// RBMX /// SNORD61PIK3CDAF186192.1TMCO1-AS1CCDC181 ZNF493CYP2E1 VPS33BLYG1 NDNFPRICKLE1 BTG1IL15RA APRTFBN2 LRRC8CECM2 ASAH1RNF150 SFSWAPZCCHC4 CERNA1FAM58A LOC100287015HSP90AA1 SFTPA2LOC101928401COL12A1PRCP UQCC2RP11-339B21.15DSCAML1TCTN2 DAP3CLEC7A DIS3L2TIAM1 ZC3H12BHYAL3 TEX10TIRAP SNHG9PHGR1 RENBPMGC12488STEAP4NID2 SERINC5SLC8A1 TOXC1QTNF7 SAPCD1DUT VCPTACSTD2 WWTR1GABPB1 KRBA1SRSF6 NR1H4CXCL14 HERC4MSANTD3-TMEFF1 /// TMEFF1CSE1LATG3 TMC5RAB40C CA11

Page 377 of 781 Diabetes

B4GALT7 TRAPPC3PRRG1 TBC1D5LOC220729 /// SDHA /// SDHAP1 /// SDHAP2CCDC151JSRP1 MRPS15XXYLT1 DNAJC6GVQW1 ZKSCAN4CXCL2 FHL2DUSP4 KCNQ1HIBCH TSLPZNF570 CLTCPCYT2 RHOUEAF1 LOC101927021SNX7 ATP6V0BSLC5A9 FAM27E3LOC400684GHET1PPP2R2A MRPS30-DTCDK13 DEUP1S100A12 CMTM8OTUB2 EP300C9orf156 PDZK1IP1FGF2 BMP4SF3A1 NFE2L1NDST4 CACNA1IKDELR2 POLA1LOC101928784ZNF503-AS1LMO2 RASSF3TMEM47 GPBP1SLC44A1 SMURF2P1-LRRC37BP1COPB1 POF1BDDC-AS1 FBXW7SETMAR ZBTB3LOC100507351GUSBP9RASSF8 SERGEFRP11-263K19.4LOC100506476FAM160A1GPALPP1VCL NR2F1CXADR RARBPRKCQ-AS1FAAHGTF2A1 CRB3CD81 H2AFVANKRD36BP2ZSCAN21LRRC41 FSIP1DUSP12 UTP14CRAVER2 CBR4ZIK1 GDF1GAL3ST4 MARCHF10UBE2F ITPRIPL2CTAGE15 /// CTAGE4 /// CTAGE8 /// CTAGE9LOC102606465SHC2 CLSTN2SUN3 TPR

Page 378 of 781Diabetes

CTD-2520I13.1RPL10LINC00520 LPAR2SLC35E2 /// SLC35E2BIRAK4GOLGA7B PGM2L1EME1 PTBP3HEBP1 FKBP1BPREX2 EFCAB10LOC101928335SLCO4A1SUSD4 DENND1AAGPAT9 ASIC2IBA57 ABLIM3MAD2L1BPADGRL2RFX2 CSF1RPSMG3-AS1SLC22A18ASRARS ZNF614SH2D5 TTC14NRG3 NFKBIZMCPH1 IFI27L2WNT7A DCAF15PTDSS2 LOC284454SLIT3 SH3BGRL3LRFN2 LOC105373383LOC102723390CYBAEDAR CSDC2MTM1 GRIK5LOC100310756GPRC5BRBM41 PSTKBLM KRT19GRAMD2 SERPINA1C15orf59 FAM229BANKS3 ERI3-IT1MCM8 KIFC2ABI2 CACFD1BAK1 HINT1FAM60A TRAM2IRF9 BNIP5FEV SMIM8LOC102724809ABHD12USH1C LINC00471CYHR1 CCT8KCTD9 SPG7MPHOSPH9SERPINA10C6orf141 ACYP1PNO1 RRP7BPAPOPT1 SLC25A14PIGF ATP5MF-PTCD1CTAGE1 PPP2R5ECDKN2AIP PNLIPRP2LOC100996412GPR37L1ELOVL2 TMEM123

Page 379 of 781 Diabetes

SOCS6 LINC00115EDARADD ZNF721ARHGAP35CMTM4KRTAP4-4 TCIMSEPT7P9 ANP32AP1IFFO2 OAZ2PLCG1-AS1RGS22IL4I1 MTERF4PUSL1 C9orf16ZNF519 TMEM260LMCD1 RPL34-AS1FAF1 LYPD3SPATA7 FYB1LOC101928907NUP160GRAMD1C FAM234BCAPNS1 BACH2FAM71E1 PANK2CRABP1 LBX2-AS1CLCC1 CAMSAP2ZER1 LAMP2DPY19L2 DGCR6SIAH2 LOC102724770LOC100131510MARK3RP11-403P17.4EDN2PARP10 TRPT1ABL2 PPFIBP1AGPAT4 FNDC3BLA16c-358B7.3POLR2J4POLI PTGIRCEACAM6 RUSC2UPK3A SPAG16AC090627.1TMEM158LOC101927330OBSL1CXCL5 LINC01806STEAP1B WTIPCIRH1A LOC105371763LOC338667EML1BC045560 PCDHGA9ATG4D TXNDC17SLC25A46 TMEM255BLOC100996286IARS2KIAA0125 LINC01637LINC00092 TMEM47IL1A BSCL2DPYS MMP1SERPINB7 DCTN3ODF4 SPATC1LF10 ZNF669NAT8L SLAIN1DFNB59 INPP4A

Page 380 of 781Diabetes

TRPV2 SAT2PABPC1 TTC8MAN2A1 TMEM139AKIP1 /// NUAK2NUP107RNF207 NEK3NOS1AP KIAA1257RP11-804H8.6LOC283177AA06 SERP2STK4-AS1 TMSB10UBE2D3 MTCL1MICAL2 DENND2CSEC61G PSEN1RPL31 CDC42BPBNOXA1 ALAS1NPIPB15 LIG3PTRHD1 PRPF31NCEH1 LIASLINC00958 ALDH9A1EZR PYGLZACN BRMS1RP11-495K9.5SOD3LOC286367TMEM41ACASP4 ETNK1PRUNE OLA1ATP8A1 BAIAP2L2TRIM69 CRYABFLJ25917 PRPS2ENAM CDK9FAM69A DNAJC17EPHX1 NKTRLOC100130691INSRMMS19 FGL2SLC30A7 ZDHHC2C6orf223 LYPLAL1PHEX-AS1 FAM216AKRT18P38 /// KRT18P38PIGRLOC399884ADAMTS15C15orf57 C4orf48LOC101927623TRAF3IP2MIR670HG CASP8AP2CD81-AS1 CBX2CT62 SSC5DHSPB1 FUNDC2CDK12 RRHNDUFB7 CEP85LAMC2 LOC100132057BTF3P13 /// BTF3P13BMP2KRP5-1085F17.3MRPL28RCAN2 AOC1CD3D POLR1A

Page 381 of 781 Diabetes

NALCN CMASELOVL6 PSG5WSB1 LINC01481RAD9A TNPO1CTNND2 MIPEPP3THSD4 CAPN2DSCC1 PCSK5XCL1 /// XCL2GRK6IL24 GNPNAT1LOC102724640DICER1-AS1VARS ATP5PDPSMD3 S100BTKTL1 RYBPDSG2 ARXNDUFAF5 KDM3APOGZ CASP10RP11-395B7.7SETDB1IKBIP LOC100996720GABRQ GAS7C1QC MRPL37HLA-DQB1 /// HLA-DRB1 /// HLA-DRB4 /// HLA-DRB5 /// LOC100996809 /// LOC101060835APPGABRA5 FAM83HLINC00029 DACT1NRTN TRAM2-AS1DGKQ GMNNARHGAP11AMIF-AS1ARHGAP15 /// LOC101928361HSD11B1KRT79 GAARP4-635E18.8LY6HLGALS8 TTC31LOC101927537TAOK3GUSBP3 /// SMA4 /// SMA5CTXND1ANKRD33BSPG11SPR PAXBP1-AS1KRIT1 LIPAC11orf1 KLF11LSM4 KCTD2MPHOSPH8NRARPRNF151 CEACAM7LSG1 FRG1-DTCFL2 PELI3RAD51AP1ERVK13-1RRAS MRTFBLOC101928504SMARCD3EIF3E EPHB2ACOT4 SLX1BAMDHD2 /// CEMP1GPATCH11CTNNAL1 TXKOSBP C2orf73LINC00865 ZMAT1

Page 382 of 781Diabetes

SLCO2B1 ACSF2RUFY3 C6orf226MGC50722OPHN1LOC100506563ASH1L-AS1ATP6V0B CCHCR1RP11-82L18.2GABRR2ZFR DHX34DIP2A ANKRD13BANKFN1 /// BC037494RBM5-AS1SPATS2L GPR183NPSR1-AS1DACT3DPH6-AS1 C11orf54CLEC12A DDNABCA2 TIAF1RASA3 MYO7ASTAG3 RNASEH2BHTR3A LOC105447645LINC00632 DIPK1ARPE BCKDKJKAMP ZBTB7BSEC61A2 SPRED1TP53BP1 SENP6IL21R-AS1 TMBIM4LOC100506699FTCDUBE2M FAM201APRR11 PAX8USP35 TDRKHZFAT CUL9DYM IGSF3LOC400043ANTKMTCNPY4 BANPFKBP1B CLN5VLDLR AATKICMT FAM189BLCN6 EFEMP2RPS3 WDR76AF001548.5EMP2MYF5 ZUP1DHRS12 NATD1TLR8 SLIT3MDH1B BSGIL6 PHOSPHO2-KLHL23IFIH1 CAMTA1CYCSP33 /// CYCSP33LOC101928371BDKRB1 GABPAMTPAP RGS10FRMPD3 COX20TRA2A NME3TPSAB1 /// TPSB2CITED4MTA2 ZNF546

Page 383 of 781 Diabetes

MAPK10 HOXA5TRIT1 SVILNUPL1 ITPAADORA2A-AS1RHOCNDUFB10 FER1L5USP2-AS1 HEATR1ATP8A2 CPMPGAP3 RAB3GAP1UBE2I ZFP37LINC01141 LGALS1TST GLB1LPLA2G4A LRRC14RP11-483I13.5MCF2L2NHEG1 AKT3XRN1 ZNF781C20orf96 CAPN3ATP5A1 BIKMIR6872 /// SEMA3BANO9RRP36SMARCC1APCDD1 /// LOC100130468MEGF8B3GNT2FHL2RPS11 /// SNORD35BCCDC135TRAFD1PGM2SESTD1TMEM72-AS1BLZF1PLK2EBF3CAND1MSCCALN1LTKRYR2ICAM1PLK4LINC00312CLUHP3GGACTHAUS5NTSMAT2BDNAJC22ZNF204PLINC01023CCNB2

Page 384 of 781Diabetes

ANO10LRRN1PRR15MEOX2HDAC10STARD3ARHGEF2UBR7SSTR5-AS1C19orf60HEPACAM2ADCYAP1ZBTB40UIMC1PPP3R1KLBSSR4CA5BFAM135BDCP1BNUDCD2ARRDC3PTBP2SLC27A2ZBED6TBX1ACVR2B-AS1PROM1NRCAMDQ570835RAP2CHIST1H4HCAPN5TMEM71SNRNP48PSMD4LCE2BHOTAIRM1POM121L10P /// POM121L8P /// POM121L9PFNBP4DDX20LRRC57PLAURCRISPLD1CREB5 /// LOC401317NUDT21BLOC1S1LOC100128840ADRBK1YTHDF3

Page 385 of 781 Diabetes

DPY19L2P2DTX3PPM1BLZTS3SMOC2LOC146513DZIP1POLR1DMYOZ1LOC285812SUSD1ZNF320COL5A3MAPK11LHFPL4LINC01354COLCA2LOC101929180ASF1ACLDN2SLC38A10MALAT1LRRC66CACHD1SPRY2CYP26B1PARD3-AS1EFNB2HYAL1SLC30A9MUC13ARNTLFRMPD2 /// FRMPD2P1 /// LOC101930006GPN1HMGB1RNF187LOC100288893LOC101929747UBASH3BGON4LSLC6A14LL0XNC01-116E7.2ARHGAP4LINC00470ZNF543LOC401220LOC101927653KAT8GPRIN3SNRK

Page 386 of 781Diabetes

MUC1TTTY10CERS2PRKCASCAF8RP11-329B9.5FREM1SCN1ARP11-502N13.2DNAJB5HOOK2SHOC2ACOT8FAM201B /// LOC648761MCHR2-AS1LOC100507480MTMR12ACANITIH4LOC728743 /// ZNF775MILR1LILRB3IGLON5DQ583756DENND6BDDX52LOC101928963LOC728061HIPK1-AS1ABCA9TDP1RNF11LINC00899BLOC1S1-RDH5 /// RDH5TTLL11RPS10TMEM177TNNRALY-AS1CRYGSCHMP4CNFKB1MYCNOSELF4RORCBICC1SSBP3ZXDAEFNA4ANKLE1

Page 387 of 781 Diabetes

RP5-1118D24.2MYO1BCPSF3L /// MIR6727C16orf92CDCA2LOC283177ALDH1A2HTR1DFASTKD3ALG13ANKRD37DBNDD2 /// SYS1 /// SYS1-DBNDD2LOC101927815SLC31A1SIM2CRY2MLECKITLGFLNAKMOPCSK4C18orf61LL0XNC01-7P3.1OGFRL1OAS3SSX2 /// SSX2BWDR45PGLYRP2GYPADBNDD1LNX1TNFPRPF4BIKBKBZNF134RPH3AEPHX4DSCAMNR4A1MOAP1DRAM1MDFIXCL1KIAA0247TPGS2HIST1H2BLZNF503-AS2EXOSC2LHX1LOC101927592

Page 388 of 781Diabetes

NDUFA13FOXP4CUTCSSRP1MMDHK1TTC13TREM2SRYRP11-669C19.1HNRNPA3 /// HNRNPA3P1LOC100131170RAB11FIP3TUBB6LOC441601SFT2D3GAB1LOC100131756SCUBE3CMC4 /// MTCP1FAM84A /// LOC653602SLC38A1ICOSHMGB3AVENPNMTS100A11P1 /// S100A11P1LAMA2TCERG1SMA4ADIPOR2ADPRHRANBP1CXCR2SNX5SYT12RP11-73M18.8C16orf87FCRL5KIFC3FOXH1FAM153A /// FAM153B /// LOC100507387 /// LOC102725213IMP4IMPAD1SLC1A5CCT6BSIRT1LOC101927044LINGO1BC044765 /// RP11-96B5.4

Page 389 of 781 Diabetes

ABCC9MGLLPTPRRTWF2SLC39A1HOXB1SLC4A3BCL2L12AK2WDR41ACAD8TNS4AJUBAMGC24103PLCG1RNF43AK024134 /// PPM1HMADCAM1ERHUHMK1RP4-794H19.1THSD7BMMEL1PANK4MAP7D3U47924.29GUCA2BKCNT2UQCRBMYO1FWDR34BCAS1SIGLEC10FMNL1TMEM61LOC100272217MIR6748 /// TMEM179BB3GALTLDUSP5ZDHHC12ZNF229GOLGA8I /// GOLGA8MPBX3PABPC3GLYATL1CDS1SLC2A4RGMKL1TBC1D16LRRC36

Page 390 of 781Diabetes

LINC01191TCHPS100A3ANKEF1FAM83EZFP36SPATA41CCR5DCAF11RNASEH1-AS1DGCR5HBA1 /// HBA2ZNF177 /// ZNF559-ZNF177ASPARP11-138A9.1PPIL6RNF141EIF4EBP2NAA11CHORDC1EI24PDHA2CDKN2DLINC00877RP1-228H13.5MGAMPRPF40AGSTO2CCDC9ARSBBHLHE23RP1-6P5.2PP2672DGKBCRTAPTXLNBTULP2FRAT2ARHGAP31ST3GAL1KIAA1549LSDR42E1SETDB1MRASPRDX3DESI1SFT2D2GTPBP8UBIAD1NMUR1

Page 391 of 781 Diabetes

SLC35F1CACNB1SYNPOSVILDPY19L2P4CFHR3METTL4CDR2LPKDCCLOC102724364 /// SEC22BFHDC1RCC2TSEN54BC042825 /// RP1-179N16.6TLCD2ZNF780BEIF3BRABGAP1LOR2A4DAZLPRPF19RSPRY1SERF1A /// SERF1BDUOX1SLC8A1-AS1MAP3K13KLHL7VPS37BCASC5KCNA3MIR6805 /// RPL28MICA /// MICBLOC100506713LINC01278LOC100287497RP4-593H12.1PDZD4PRO2964ARHGDIADHRS4-AS1BBIP1LOC101926975ZNF84ST8SIA1CD79ARTN4RTMEM102SERPINF1RNASE6FAM27E2 /// FAM27E3

Page 392 of 781Diabetes

VEZF1MAD2L2MCM3APACTR10FIS1RAP2AKHDC1LZTS2MORC2-AS1RP11-67L3.4GLIPR2FLJ13744RD3ATRNISOC2LRTOMTSGPP1TNFAIP8RAB7BZNF442PGAM2SHC3CLCNKBCSMD2NAPRTASB16-AS1ADMSLC9A7MS4A3LOC101929709CCDC130CLDN1OR1A2CYP4F2PGS1PVRIGSLC35C1LY6HLOXL1-AS1VAMP4UBBP1 /// UBBP1 /// UBBP4 /// UBBP4SLC7A1LOC101929864 /// SLX1A /// SLX1BADAM12ARMC7SCAND2PTRAF5TRMT112SPIRE1ZNF175

Page 393 of 781 Diabetes

RNF139-AS1RPLP0HIST1H2BACCDC105NWD2DPYDLOC285957TMEM239GFM1CITED2IL19TMCO3CCL27TAF5ADNP2MINOS1C6orf226KRTAP1-1PDXKFLRT2 /// LOC100506718 /// LOC102724348RPS10LACTR5FGD2FUT3RPS6KA3AK098263H2BFSC5orf47LOC100506207CCDC42BRAB11FIP1UBXN10-AS1GEMLINC00606KIAA1614NT5CASGR1ZNF541GNA11SLMO1ZNF671HOXB-AS1SLC25A12ALBWNT11HLA-DQB1 /// LOC101060835LCKECT2GPC1SLU7

Page 394 of 781Diabetes

RMDN2UGT1A1 /// UGT1A10 /// UGT1A4 /// UGT1A6 /// UGT1A8 /// UGT1A9USP32 /// USP6GPR39COL9A3LOC145474ABCC1KIAA0485CLASRPAL833181R3HDM4UBE2BPAK6SFXN3C10orf25RELL2ZNF765VEZTCCDC142AKR1C4KRT10CHSY1RP11-714L20.1ROGDIKHDRBS3LOC101926915GJA1SDSLCCND1VPS8LMAN1SLC12A7PDDC1FBF1SLC17A5RP1-223E5.4 /// SIRT5FAM132BNDFIP2ZNF512SLC6A4MYL7SMARCA4PRDM16MAPK7RP1-130G2.1KIF2CNUDT19APCDD1LMGST3MAGT1

Page 395 of 781 Diabetes

MTHFS /// ST20-MTHFSSLC7A11-AS1LOC100505938C10orf55CARTPTSYT17AOAHCD8ASCRN3S100A10FKBP4PEX16MLXIPLKLHL12LOC101928014ZNF711LOC344887MITFAURKBPPY2ITCHPSMD6-AS2ZNF684ADM2SLC41A2CYB561D2CRB2DLEU2 /// MIR15APSTPIP1ICAM5MAP4LOC101929745LRRK2LOC338620CDCA5SENP2HCG8 /// ZNRD1-AS1LACC1AGAP3BC062753PTPRKMTF2NLKFXNAGKPLCB1SPTBN1CRIPTSTARD13CTD-2033C11.1

Page 396 of 781Diabetes

RHOCDMPKKLHL35NAA16SRP19CD83CDX2USP9YHIST3H3SLC34A2CCDC97B3GALT5ABCA11PSCART1AC010980.2 /// LOC440934 /// LOC440934PDLIM7LOC101929143ATF3KIAA0196PRKG1CTD-2292M16.8ZC3HAV1KRT14LOC101929570MAFFAGERSULT4A1ACTR3FBXO9IFT122 /// LOC101927266CALUMEX3COCRLGKAP1C9orf3SCAMP2RP4-657D16.3CD2BP2ZNF226CDKN2CB3GAT3LOC101929076SLC29A1PLEKHN1RUSC1-AS1PIEZO1UGT1A1 /// UGT1A10 /// UGT1A3 /// UGT1A4 /// UGT1A5 /// UGT1A6 /// UGT1A7 /// UGT1A8 /// UGT1A9PABPC1L2A /// PABPC1L2BLOC100506504TP53I3

Page 397 of 781 Diabetes

PSPC1SETBP1MIR6878 /// TARS2CA14HEMK1LOC285181LOC283745LIN52PSAPL1DNM1P35CLN6SRCIN1CACNA1CFBXL14BTNL8IGFBP6LOC729732TSC22D1KDM2AWDR5MS4A8CYP4F62PRP6-149D17.1THRB-IT1 /// THRB-IT1RDXABCB9SLC9A1NR2C2APCD3GUSP19GPR160SULT1A1ACSL4ZNF789RFX1ATP11CGNL3LCCL14 /// CCL15-CCL14MYO1CCPDAAGABGAL3ST2CPSF2DAZAP2 /// LOC102723983SDK1PRSS8HLA-DPB1LAMTOR1BC031864 /// LOC100507330 /// RP11-588H23.3SSTR4

Page 398 of 781Diabetes

ENC1ANXA5METTL15STAM2PRO2949FAM213AKLHL24PTGDSRASL11ADCTN1 /// SLC4A5PDLIM2HOXC12SERHL /// SERHL2RHEBL1DNAJB6 /// TMEM135FAF2RBL1JAG1C17orf49 /// RNASEK-C17orf49MRPL16PLEKHG4BLINC00884GAPVD1SPATA1EXOSC1ALDH1A3DNPEPBIRC5 /// EPR-1AP1B1C14orf2HS1BP3EP300-AS1S100A13C3orf35SH3BP4RPS6KA4SPINT1RP11-69I8.2RPL27ASENP3UTP15XRCC2DLEU2LSLC7A4RPS8AGTRAPTRAP1EPB41L3KATNAL2STK24-AS1

Page 399 of 781 Diabetes

MIR29A /// MIR29B1RPUSD4RAMP2TREML3PBRICD5AVPARXKLHDC10PF4V1SIK3DIS3LMAP7D2PDE1CSHROOM1KIAA1958PTPLAD2BEGAINKCNJ8CICSVEP1XIRP2CLEC10ACDCP1GOSR2COQ7FAM127BC17orf77POLE2CTPS1LOC286083STAG3L2 /// STAG3L3 /// TRIM73FSD1LLEPRCOG4TNFRSF10ACCDC30HNRNPA1P31 /// HNRNPA1P31APOHBBS4FLJ23867 /// QSOX1VWA8SLC39A13VASPSDR39U1S1PR5PPIAP21 /// PPIAP21CCT3 /// LOC101927137COL7A1LOC389834 /// MAFIP /// TEKT4P2C6orf163

Page 400 of 781Diabetes

NHEJ1 /// SLC23A3ARPC4 /// ARPC4-TTLL3SCO2PEX11ANCAM1LDLRPATL1EGR4AREGC20orf194SCN4BRP3-486D24.1C1orf87TDRD12ZSWIM5LOC101928682C12orf61UQCRQBBS1ND4LOC100507311STAB2ADAM17CHGBDNAH14PAXBP1-AS1DENND1CPMLLOC101928388PPP3CCIKOGDHLPCID2CAMKMTCFH /// CFHR1LOC100130700RPS19ABATGLMNKAAG1CBFA2T3HSPB3KCNJ3LOC101927673 /// OTUB1LGALS9FAM222A-AS1FUT6ZNF121GPRC5BSLC26A11

Page 401 of 781 Diabetes

PCNPKIAA1324TPX2USP38ZNF286ALOC102725382WFIKKN2LOC101928068FAM46CHOXB6PCA3EMP2MBD5AK7NUS1 /// NUS1P3UBR4CAMK2ATMEM158LIMA1ZBTB24ERVH-4KPNA6TAP2LOC101928625 /// MED21STK33IDO1TRIB2LOC286071ZNRF2DDAH1GATA3LOC100507577 /// LONP2CPNE9TSPOC12orf5TARDBPZSCAN12P1RAB8AUBXN7RAB3GAP2VEGFCFCN3JOSD2RBM18WWC2RSPO3CELF3SOD3CTD-3080P12.3TOMM5

Page 402 of 781Diabetes

CCDC152AGRNMGPLOC100996542PRMT3CCDC14TXLNGYTAS2R10SLC2A10TOB1-AS1EFCAB4BMEX3ALCN2NMRK2LINC00086PICALMULK4CHATDDHD1EVI2AFSTL3POLD4CSRP3MOB3APRRX1ZNF252P-AS1BRAPRP11-263K4.3FAM50BLOC101928729PIGQCSNK2B /// LY6G5BCDC42BPBEDN3LOC284648HAP1PTCH1ZP1BRI3 /// FLJ30064LOC101927157 /// NIPAL1GGA3RP11-473I1.9LKAAEAR1LOC100996385TRIP12NDRG3GLYCTKNDNFBC042366FUT10

Page 403 of 781 Diabetes

LOC100507600LINC01125CYP2D6 /// CYP2D7P /// LOC101929829CLMPAC114752.3KLF3ARHGAP8 /// PRR5-ARHGAP8CLCA3PMED20CCSAPEFTUD2CRTAC1PHF12CCDC150LINC00883RBM14-RBM4 /// RBM4F2ARHGAP22-IT1S1PR3CENPP /// LOC100128361LOC100506639 /// ZNF131LOC101928495TBL2DLX5NUBPLZBED4ENOSF1LRCH1CEP63AMPD2DDX3YELAVL3LRRN2LINC00282TMEM237PLCD4LMNARIMKLBSIRT4IFNAR1SYT3GEMIN4NAB1EPS8L2ACAA1AF198444KRT8P11 /// KRT8P11STYXRPUSD3FAM20A

Page 404 of 781Diabetes

STIP1AP001462.6TSEN2SH3D21ATPIF1AOC3GRM2IRS1HSPA14RP11-384L8.1RASD2ETAA1FLJ35934SUV420H2ANKRD1SCAND1UBA52KLHDC7BSOX9GGNWAPALZNF35MCATNARS2RP13-122B23.8WDR37C11orf30TRIM66CYCSP19 /// RP11-3L10.1C16orf13PERM1MED31ARHGAP25AP1S1SPINK6MYO5ACHL1-AS2 /// CHL1-AS2ZBTB37IGF1EXO1OXGR1FKBP11FAM71BUXS1GLI1ECI2ATXN2CPT1AMEIS1SOX21-AS1

Page 405 of 781 Diabetes

CD97RNASE7CDC42SE2ACEFAM207ASLC20A2FBRSL1KIF15A2M-AS1ABI3ACSL1ACSL3ADHFE1ADI1AGKAGR3AHCYL2AK8AKAP5AKR1C1AKR1C2ALG9ALOX15AMD1AMTANGPTL4ANKRD13CANXA9AOC3AOC4PAQP4-AS1AREGARFGAP3ARHGAP11BARHGDIBARHGEF11ARHGEF28ARPC1BARRDC4ASCC3ATF3ATP8B3B4GALNT1BDNF-ASBEST1BHLHE40BRCA1BRD8BRINP2C10orf76

Page 406 of 781Diabetes

C1QTNF1-AS1C20orf196C20orf96C21orf62C22orf39C2CD4AC2orf76C4B_2C8orf33C9orf116CA11CA14CAMSAP1CAPN3CBR4CBX3CCDC102BCCDC121CCDC150CCDC152CCDC34CCR1CCR5CD247CD27-AS1CD82CDC6CDCA8CDH24CEBPGCELF1CENPHCEP68CEP85LCETPCHADCITED2CKAP2CMBLCNN1CNNM3CNTNAP2COL22A1COL6A6COPG1COPS7BCORO1ACPT1ACREB3CREB3L4

Page 407 of 781 Diabetes

CRISPLD1CSPG4P1YCSRNP1CTNNA3CTNNBIP1CTSFCTSZCXCL1CXCL8CYP26B1DDIT3DENND6BDEPDC7DLGAP1-AS1DNASE1DPRXP4DPY19L2P2DRICH1DUSP1DUSP5DYNLRB2E2F7ECM2ECT2LEDAEDEM1EDEM2EDN2ELMOD3ELMSAN1EMX1ENPEPENTPD3-AS1EPDR1ERMAPETV5EZH1F2RFADDFAM134CFAM182AFANCD2OSFARP2FBXO24FCMRFDX1FEZ1FGF14-IT1FGF2FICD

Page 408 of 781Diabetes

FKBP6FKBP7FOSFUNDC1G6PDGALNT15GAS6-AS2GATSGCLCGCLMGDF5GEMIN7GEMIN8GJB2GKGNGT2GNL2GNL3GOSR2GP6GPAT3GPR3GPSM3GRAMD3GRM3GTF2H5GTF2IGTF2IP4GTF2IRD1P1GTPBP2GZMBH2AFB1HAUS1HIST1H2ACHLA-DMAHLA-DMBHLA-DPA1HLA-DPB2HLA-DRAHNRNPUL2-BSCL2HSD3B1HSPA5HYKKIARSIER3IFT74IGDCC4IGFBP1IGFBP6IL1RN

Page 409 of 781 Diabetes

IL5RAIL6IMMP2LIMPG1ING5INTS3IQCB1ITIH1JMJD7KANSL1KCNJ1KCNJ10KCTD2KIAA0101KIF15KLKB1KMT2E-AS1KNG1LAMP3LCP2LEAP2LGI1LHFPL3-AS1LIASLIFLIG1LILRA1LILRA2LILRA3LILRB2LINC00312LINC00511LINC00693LINC00885LINC00899LINC00933LINC00958LINC00964LINC01091LINC01140LIPALOC100130899LOC100289230LOC158435LOC283038LOC389641LOC728024LOC93622LOH12CR2LPCAT4

Page 410 of 781Diabetes

LRP8LTBP2MADCAM1MAFFMAP2MAP3K3MED18METTL1MFHAS1MGAT2MIR497HGMKRN2OSMKS1MMP19MMP23BMNS1MOXD1MPZMROMRPL36MRPL44MSRAMSS51MTCL1MTHFSDMTRF1LMUC20MYOZ1NANOS2NANSNAPEPLDNAPSANCAM2NCF4NCKAP1LNCKAP5NCSTNNDEL1NEK4NIPAL3NIPSNAP1NMNAT3NOP9NPHP1NPM3NPPA-AS1NPTXRNR2C2APNR4A2NRADDP

Page 411 of 781 Diabetes

NRBF2NREPNRN1LNRROSODC1ODF3L2OR13J1OR51E2ORC6OSCP1P2RY13P2RY8PAGE2PAQR7PATZ1PBX2PBXIP1PCBP1-AS1PCED1APCNAPCOLCE-AS1PEX19PGAP3PGM3PGM5PIFOPIGAPIGVPIK3C2BPIP5K1APITPNC1PITRM1PITRM1-AS1PLCB2PLEKHG4BPLIN2PMM2POLDIP3POU2F3PPP1R15APPP1R26PPP1R32PPT2PRSS56PSMA3PSMC4PTCD2PTGER1PTGS2PXMP4

Page 412 of 781Diabetes

R3HDM2RALBP1RANBP10RAPGEF3RARRES3RASL11BRASSF1RBBP8RBM14RHOBRNF135RNF223RORCRPARP-AS1RSPH14RTTNSDHCSEC23BSEC24B-AS1SEC31BSEC61A1SEMA4DSEPP1SEPSECS-AS1SERPINA7SH2D4BSHHSIGLEC10SIRT1SLAMF7SLC15A3SLC1A3SLC22A18ASSLC25A20SLC25A21-AS1SLC26A7SLC33A1SLC35E2SLC46A3SLC7A11SLC7A5P1SLC7A5P2SMARCD3SNHG1SNRPA1SNX20SPAG8SPATA17SPATA32SPEF2

Page 413 of 781 Diabetes

SPIRE1SPRED2SQSTM1SRP14-AS1SSTR5-AS1ST3GAL4-AS1STAC3STARD4-AS1STC2STPG1STX6SUFUSUMF2SUMO1P1SUN1SUV39H1SYNGR1TBC1D13TBL2TCTEX1D2TFDP2TGM1TMCO3TMEM147-AS1TMEM218TMEM39ATMEM8BTMEM91TOB1-AS1TOLLIP-AS1TP53TG3CTPTE2TPTE2P5TRIM16TRIM16LTRMT6TRPV3TSC22D2TTC31TTC32TTC39BTTC41PTUBB6TXNRD1UAP1UBXN8VCPVPS37DVPS52VTI1A

Page 414 of 781Diabetes

WARSWASH5PWDR63WDR88XPCYWHAHZBED5-AS1ZBTB21ZBTB49ZCCHC4ZMYM3ZNF135ZNF165ZNF205-AS1ZNF252P-AS1ZNF280AZNF383ZNF404ZNF487ZNF526ZNF571-AS1ZNF691ZNF763ZNF85ZNF862ZSCAN12P1

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UGT1A1 /// UGT1A10 /// UGT1A3 /// UGT1A4 /// UGT1A5 /// UGT1A6 /// UGT1A7 /// UGT1A8 /// UGT1A9

Page 602 of 781Diabetes

Overlap total GenesT1D-BFA 2289 MSRB1

SLMAPRALYLERCC5CXCR4TMSB10ESYT1SUMO1CCNILINC00683PNPT1STK16BANK1NINLSCYL3SORL1C20orf27DHRS11CMPK2CDC25BPOU3F1COL1A1PDCD4SMYD3ANKRD6ARHGEF9VWA5ACNPY4BUD31MAOARFXAPRNF4CDK8SYT13FPGTNTHL1KIAA0100CD82PTP4A2ID1FAXCNIPSNAP3BMMP15DNAL4IPPTMEM59SNX6

Page 603 of 781 Diabetes

HLA-JCAPN1IGSF11SDC2HABP4TMEM125ASNSD1RP9ARAP1OSBPNBPF3ASAH1RTN4RL1OSGEPUNC5CLMOB1BOLFML2AUIMC1ZNF667ZNF738NENFZNF487TTC13CYP3A5CENPJAKIRIN1ZNF568ITSN1TTC3SEMA3GFSTARHGEF26METTL7BZMYM5ZNF586SNCAIPPELI3LIMD2PECRSERP1CASP1SECTM1B2MEIF5ANEGR1PLRG1SPG7NUP133

Page 604 of 781Diabetes

SNTA1PPIDIL20RAPSMD12TAF1DRABGGTBDICER1-AS1CALCOCO2GEMIN6ARSKLINC00641PROS1PSMB8SLC16A11APOL1ZBTB7CVAT1MAST4SOCS3TMEM132ACGRRF1PIANPISCA1SLC25A39ABHD14BALAS1FOXO1PSMA5PYURFZNF3CBX2ABI3ALDH5A1CRTAPSTMN1DPP6GRID1ATL1USP38ARHGDIBMAGEF1ASB4SLC12A7LINC01139MAN1A1NEIL2PCDH12TCHP

Page 605 of 781 Diabetes

ZDHHC1LRRC32SLC29A4BATF2CKMT1BSHECCDC117IFT172NTRK2TMEM182MFGE8PFKFB2PRMT5DCAF4ETV3ALOX5APRIPK3POLR1BOLFM4SAMHD1SH3PXD2BSCG2ITGBL1KLHDC3IPPKGNAI1CPXM1SESN1FARP2ACOT11PRKD2MXRA7LGALS3GLT8D1UPB1MCOLN3PALMDCCNB1IP1TMEM43KCNG3OAS2ATXN7L3DBNDD1G6PDRTCANRG3ABCC5C14orf93

Page 606 of 781Diabetes

FAM156AMAP3K12ZNF121CMTM4C5orf30NUDT16L1SLC26A2RAB22ASTAU1SLC15A3MESP1HEY1CASRLIN9IRF2GNG7HEATR6RUNX2SRPXCROCCP2TSPEARTHRANAB1TP53TG1CA8LAMTOR4ICAM3ADAP2BCL7BMAN2B2FAM124ASLC39A10DTD2DAGLACHCHD6SLC2A4RGCLEC2DHCN4NPM3RARRES1SLC46A3ADCY2LDLRAD1ZNF135FNDC3BMICAL1BLZF1DUS1L

Page 607 of 781 Diabetes

GSTM5APBA3PMS1SLC25A51ZNF814CTSOHIBADHIGFBP3SFXN4PLA2G12AN4BP2L1PITPNC1NCOA7NKX2-2ANKRD13DGALNSKCNJ11TPRZSCAN20SLC45A1KCNJ16METTL17IRF9LBHSYNMCHCHD2SLC4A4FLIIRPS16CHPFMAP7D1TRAM1L1TMEM208MAFFCISD3EHHADHRBAKFKBP9P1ITGB5HIST2H2BESHMT2VWA3BNDUFA5UQCRHRCBTB2ZADH2MEF2CKCTD14

Page 608 of 781Diabetes

EIF4EBP2CHST8THEM6HSPB6ARV1GSTA1TRAF3IP2NID1C1QCSMARCC2UCNZNF764USF2NDST1PELP1ZNF230THOC5EPDR1GPNMBAKR1B10TIGD6SLC39A14RGS16BCO2MOB3CLNPEPAPCDD1LDDX27RERGCHMP5CACNB3ATP6V0BMAGEE1CNTN4RAP1GAP2PLEKHB1ZFP37PGAP2SAMD13UGT2B15EXD2FZD2MRAP2NOVA2PPP1R8CCNI2PDE6DGNG10

Page 609 of 781 Diabetes

APOL4HDDC3HMCN1CD40ZNF318WTIPPACS2HACE1ARL4CSCD5LSG1DMPKSLC7A14SMYD5LIPHC3orf33CYP4F3TMEM230CROTZNF543STOX2ZNF566ABCB1STRADAMTF1SMIM8FAAHLTBP2ANKRD42PDE9AZNF502ANXA6HIST2H2AA4EMID1TMEM132CMFSD2AMAP3K8STC1TMEM14ATCP11L1SULT1A1RNF19BABCC3HLA-DMBEXOC8HLA-AFAM229BUBXN10

Page 610 of 781Diabetes

STAT3SYNJ2MBD4SLAMF8ANKRD11EIF5A2N6AMT1FBXW9HEXBGALNT12SLC35G1CRLF1PYCR1PRR15LZNF497SLC30A4LINC00473CDH6THG1LADAMTSL2CSE1LUGT1A6RCAN3ATG13NMT2OSGEPL1PFKMDKC1GCHFRGRAMD4UBDMRPS26DNAJB6PELI1RFC4ABLIM2KAT2AARRDC4TRAPPC10CPQCNOT10MR1FFAR1TCAIMGDPD1NUDT3CAMK2GSRSF8

Page 611 of 781 Diabetes

HMGB2LINC00870KANSL1LTMEM100UBAP1LMVB12BZMYM3CASP3ZNF429ZNF461MAGEH1RGS2NAPAPSG9BTBD3ACSS1UBXN8MOV10TMEM150CSERGEFB3GALT4LEAP2CC2D2AB3GNT8CAPN13HTR2BPGRMC1LYNDUSP6NAP1L3ELK1AARSD1ADAM33LGMNNUDT11SNPHID4INAFAM136ACLEC14AGJA3ENPP5NQO1SLC35E4SURF1ZBTB1GIMAP7SERPINB1

Page 612 of 781Diabetes

ZNF226ZNF773BAZ2AZSCAN25SIL1LDB2PGAP3C21orf62LOH12CR2FMO5TNFRSF1BGTF3C4IQSEC1PATZ1PCDHB16SLC25A6ISG20CASZ1GJD2SNHG8RASD1MRPL40LY6HGSTM3EIF3LKCNA5FLRT2SERAC1ANAPC5DZIP3NFATC2IPRIT1SCML1RHBDF2MEAF6AQP1CDC16KIAA1614WDR5SLC41A3IFNGR1NOL9SLC29A2MATN2ARHGEF6DEAF1PPP1R16BCIB1

Page 613 of 781 Diabetes

COBLHLA-DRB1KIAA1328SLC25A28TMEM150AECHDC2CUEDC1RP9PNDUFA9CTPS2TBCKRNF130UCHL5ULK3TIMP2RARSPPP1R14CRASL11AGPRC5BKITLGHSD11B1CTSHMFNGCDC5LTRIM59ZNF12GSDMDTOE1PPA1ACOX2COA3C1orf116KRBOX4CALHM2PAM16TRNP1TRIM25HOXB2GATMCHCHD4HEYLCUTAVAV3SUOXIDH3BSLC18B1LRP11MTERF2

Page 614 of 781Diabetes

LOC730101GATA4PRKAG1C2CD4ANDNARNT2SPOCK1H2AFYAPBA1PLCE1PIGXAPOL2HSPB1U2SURPCYP39A1AMZ2TPRG1LANKRD13BNWD1SLC38A5UGT2B17CERKFXYD6HLA-DRB5CASP6OAZ2POLR3KTMEM240PARP16PDIA3TMCO3BIRC5GNASTSPAN13BCLAF1ARHGAP39BBS7CCDC57GTF3C3TPI1DNAJC5GATA6RASGRF1ZNF484IP6K1SRSF6GJB1FRRS1

Page 615 of 781 Diabetes

RWDD4MAFKBCAMHLA-DRASERF1AFUCA2EBPLGMFGPIK3AP1AFAP1L1ZBTB18CLSTN2WDR20NTAN1ARL2BPSAC3D1COLEC11RHOBTB2FRYLZNF432IL27RASTON1FOCADCBX6TTC21BATP1A1ACVR2AGNAO1SNHG9TMEM140NUAK1CCL26RALGPS1CCDC6MTHFD1SEC63CCDC113PAFAH1B3CEBPDG6PC2ZNF417DIXDC1CHAMP1BMP8AFAM114A2PDGFDPSMC4ANKRD22

Page 616 of 781Diabetes

FGF14-AS2P2RY8TRAPPC2KRT8LMAN2LC1GALT1C1NFKBIZNSMFPANK1ZNF157PTGS2UBE2D3SLC25A34ENTPD2ZNF362ZNF781HAS2NKAPSLC30A7S100BUBE2Q2UGT2A3SYT7DPY19L3OLIG1EDA2RPLCXD3PIM3KAT8DMXL1SCFD1RASGEF1ACTU2FGFR4TRIM14ABRACLSLC7A11TINAGL1DOCK4FHAD1CHST2ZC3H12CACAA2FCMRPIGKTSPAN2CTSFHUNK

Page 617 of 781 Diabetes

FBXO25ALKBH7NME4DLL4IRF2BPLSMARCA1PLXND1TEAD4PIGBZNF608SLC25A42MMP11LRFN4RAB24CARHSP1CCDC102BHDDC2MDGA1VPS35DBPCOL4A2ZC4H2HAS3HEBP1C1SGLO1CD302ZNF835AAR2PLD2LDLRAP1C5orf63PLCH1HECTD1INSM1ZNF493GLRA1FAM102ACTNNBIP1LIASGADD45AUGGT2PSDPLATCOPEEIF3ACOA4YRDC

Page 618 of 781Diabetes

KIF12RASL12FSCN1SRD5A1POLDIP2HSPA14C1QTNF6OPCMLDTYMKCD74PLSCR1LIPGFEZ1NRGNDNAAF2RNASEH2BVAMP5DNAJC27LACC1MTFP1FOXS1ZNF423SLC43A2GUSBGSDMBCOPS3NID2TMEM97EXTL2MACC1TCEA1ZNF853FAM76AIFNLR1SBK1ADTRPPDE4BMAFBRAC3TMEM14BSEC14L6DNTTIP2PCYOX1LC18orf32TLDC2PLPP3BAG5SDE2

Page 619 of 781 Diabetes

PPA2PDCD1PALD1ZNF32FAM53BCATFAM78BSEMA4FPPP1R11GCNT3BNIP3LSTXBP1ADMLSM2CD22IMPDH1C9orf40IDH1RAB1ASHISA7WHAMMUBALD2ABCC1TDRD7WIPF1RNF181TXNL4BRNF114ITGA7NLE1CEACAM1PWWP2BEPAS1UBTFMORF4L1ANKMY2ADNP2SEC24AIFITM1GAS6AMOTTSHRGSTM2ASB9PGS1PPARGC1BEPHB2BHLHE41

Page 620 of 781Diabetes

FAM222AANKS3ZNF883POLA2ZC3H12BSCO1KAT2BAMER1AS3MTB3GNT2EYA2DCAF17CKAP4WLSOATIQGAP2PRCPNDUFB1LINC00643TAF5LCOL22A1MSCDCKHMGB3HOMER3TUG1SOX13GKPTPDC1IKZF5AKAP7DNAJC22GRK6PIGZTCHHCYP2U1MTHFRDACH1CALML4MPP7MRPS34ZC3H7ARASL10BHENMT1RAB37LMLNCSF1TNFSF10

Page 621 of 781 Diabetes

DTX3LSCINFAM86B1CENPHZNHIT1COPZ2ELF3MYEF2ZNF665DHRSXFAM135BKLHDC7BPIGRRAB11FIP2NRP2ACP2MROH7PPARGTMEM44C12orf10ZNF441KCTD5PARP14EPB41L1FOXJ2ZCCHC18IL17REKIAA1549LIFIT2MAP2K6ZC3HAV1SLBPSTEAP4C11orf71NPTX2NME6CTSSANO1AKIP1RAMP1EDN3NALCNSMAD7FHL2PSMB2CDC42BPGWARSRGL3

Page 622 of 781Diabetes

BTBD2LMO2DDX60RPL22NYNRINRAB33ASTK32AZNF792AK9TTC39CINTS10ALDH1B1RAD51CFAM168BGAMTDRAM1CXorf40ANOX4FRAT2SALL2PAPPA2STK33SNUPNCLCN7PCDHGA9NAPEPLDDDA1CBX8COQ3KYCTSDFKBP1BCENPBD1P1SMIM19TMEM80OCIAD1RBPMS2TCEAL4BCORCMTM6GRB14SEMA4BNIPAL2CCDC151EXOSC5SPATS2KMT5CFUZ

Page 623 of 781 Diabetes

SURF2SLC7A8EPHX2KARSPTGDR2LIMK2HHATMX2SHFCCDC68NDUFC2DUOX1UBE2G2ZNF618STX3SLCO4A1AP5Z1DPH5HLA-FRXRGZNF140SLC11A2NBEAL2TMEM158ANKRD16MYD88ZNF276RBCK1DENND2CGPR37ANKRD39TNFSF4ERICH2HTR1FSCPEP1INHBAMTG2XPNPEP1ADPRHTRIM21CFINLRC5FOXRED2SORBS1CHST9WDR25MTURNCACNA1A

Page 624 of 781Diabetes

TCAF2CYS1EMC4PAXIP1-AS1HADHIFI30DDNGJB2DNPH1HECTD3RAPGEF3SCARB2USP34FGD1EDC4HSP90B1TNIP2SPC25STAP2SIDT2TMEM231ATP6V1G1C16orf46DDCLYPD5GLRX5CYLDWSCD2WTAPUBE3DSERTM1USP48C1orf35THUMPD1CYP26B1APCDD1CMBLTMEM163GNB5IL16VCLRAVER2SMN1AKAP5PPP2R2DCENPVPLLPNAF1

Page 625 of 781 Diabetes

LMTK3ZNF93MESTSARDHLY6ES1PR5NRBP2CUL4APDZK1CFBPCP4CXCL6PDLIM3GMNNIRF8SS18L1TIMM21BCL3ZNF222HEPACAM2SUPT6HTMEM199SBK2ZNF30FZD1LAMA4ADPRHL2NDUFA10CLIC2TEX30CLNS1AING1ETV6TMSB4XCEBPBZNF398CAPN7ALKBH3PARD3NRG1SLC4A11DGCR2DHRS4-AS1UNC45ACISHOGDHLFUNDC1MYBPHL

Page 626 of 781Diabetes

FMN2SNX21SNX17SPOCD1KCNMA1PFKPEPB41L4BCPXM2ANAPC4CCDC28BHEPHPDLIM2COPS7AWSCD1LRRN1C4orf3NFIAACTR8ITGA3ZNF510TMEM19RUNX3ZNF623PHLDB3UGT2B7LINC01138C1QTNF3TRAF5LINC00261MFFNOA1TIAL1GSTA2CORO2AETNK2VAT1LNRARPCCDC43OPHN1ADH5DESI1TMEM255ABCHEKLHL41ZNF239KIAA1324WDFY2ZNF284

Page 627 of 781 Diabetes

C12orf75PXDNC1QL1A4GALTTOMM34CD6PSMD11ALADGSTM4SAMM50TSPAN7ZSCAN32ARL16THAP1PCDH18DPYDMED27ABHD12AGTIL6RUBAC2-AS1CLDN6EPHA4ZNF70ZNF655MRPL15RPUSD3UBE2L6ENHOTSNXPCCEP85STAT5AHCFC1SLC3A1COQ10BNRF1OPA3PAQR4JADE1MICALL1GPBP1L1TNFAIP6ZNF709BRD4SOX9UBTD1SVIL

Page 628 of 781Diabetes

OAS1PHB2IGSF9TCF21NECAB2ZNF419FAM177A1TFE3RAB20GTF2H5ZNF710SUMF1HCFC1R1LYPD3SAT2KIAA0753GABREPPCDCKDELR1CD83SLC16A2KDM6BMGPCYP4F12FKBP5NUB1CCDC85BSYNGR4GCH1TMEM106CDNAJC4PARVBCSRNP1NRSN1GOLGA6L9NRXN1ASIC3SLC37A1GGT6IL10RBARHGAP10LIN7BVCPPCSK9APOBEC3FRALBGPM6AGBP4

Page 629 of 781 Diabetes

USP51MMP1CEP104LINC00662GTPBP2SETD3ELK4TP53I3UCP2SLC22A5ASPNANKRD65URB2YBX1SCTRAAASDACT2KCNH3PCED1BASH1L-AS1WDR70SPAG5F13A1FAM8A1C9orf72SLC44A3HACL1BLMHRTN2CHD7SLC30A8HIC1MYSM1SERPINI1TMEM38AKLHL15RAB2BMAP3K15ZMAT1SNX5CAPN2LRFN1FZD5NUDT8ZNF763ZSCAN21MYT1LAPOOL

Page 630 of 781Diabetes

ERP27CNTN1BBS4CLPTM1LHS6ST1TTC39BKIAA1257ZNF544C2orf72HM13TCERG1TOM1L1THBS1SNAPC5SPATA18TBX3WASH5PDAXXTAF11HIST1H2ACAPLNSSR2GDF11NEURL1PDZD2SLC24A1PTPN6RHOQZER1POLHSNAPC2FILIP1LGAS1ZNF263STK32BABHD10RNH1DCXRMYL9PDIA6LURAP1LPBXIP1CXorf40BEHD1EFCC1MTERF3FAT1NREP

Page 631 of 781 Diabetes

CELSR2CSTBHILPDATMEM50AGTF2E2NMT1ATG12SWI5PREX1DMWDVIPAS39CALD1SCRT1ZNF404TMED6LRRC27POLR3FTSTD2WRNIP1ST3GAL5PSMA6ALMS1ABHD14AAMPD2IFNAR2CYB5ATSFMABCC8WDR3STMN2HSD17B14MAP2K3FLT4NARSPEBP1COL1A2SERPINA5AKT3PHF11ARSJBAATRBM48COL12A1ABLIM1ACKR3FAM171A2NYAP2HDLBP

Page 632 of 781Diabetes

HOPXMFSD3ESM1ARHGEF10LRAE1CCNA1LRP3ATP6V0D1POLR1CZNF385DRNF170PTK2BLINC01106UNC5BCALB1ZFP3DIAPH2ACVRL1ALKBH1SNIP1CLDN11TIMP3MXRA8MAML2SPAG16RAC2B3GNT9SCOCNAPGPLCG1TAGLN2RBM33THYN1KATNAL1CAMSAP3C14orf28ARL5BTMEM223VWA8CYSLTR2ALDH4A1LINC00511CRYABRASD2ZNF175SLC40A1CD36KIAA1143

Page 633 of 781 Diabetes

HMGN3C1QTNF5LARSBCL9ZBTB2PI4K2ATCEAL8PDXKIFFO2ITGA1FAM24BMERTKBAG1COLGALT2PRKCDTRIM65TP53INP2TMEM74TAPBPRUNX1SNX10STON2ABCC4FAM171A1MAGT1ANXA9IFITM2EARS2SH3BGRLSLC25A22GJA4KIAA1217C2CD4BPLEKHG3FRMD6AKR7A2VEGFCZBTB16REG1BSUMO3SPRSAMD9LARHGEF3ADAMTS4RWDD3SLC25A29GID4TMUB2

Page 634 of 781Diabetes

IFNGR2ZNRD1ASPTBC1D20DUSP1BCAR1CDC42EP2C1orf52LRPPRCTM4SF18TMEM169SNX2ATP1B2NKX6-3GRHPRNEUROD1PARP2PCDHGB2NDFIP2ZNF134TMEM183AALDH7A1SRGNEIF3FEDEM2CCNJLEEF1B2SCARB1CAMK2N1SPCS1LRP10MGMTEXOSC8SIGMAR1LPAR2CDC7SNX7BCL7CPPANRNF213CNEP1R1TNFAIP1ACETIGD7FOXP4CACNA1DSGPP2CD163RGS5

Page 635 of 781 Diabetes

PRKAR2BBBS2CLSTN1FUT1NOCTLSP1LRRTM4GMPPBIFI6FRMD8MGAT2AIFM2NLNPOLR2KFHOD1CDK2AP1S1PR1GK3PRAB3DZKSCAN8ATP6V1HMUL1KIFC2ZNF777PABPC4SPRR2ANR5A2OXGR1HELLSTMEM260NAV1PLAGL2PDCL3P4TMEM109FAM90A1PRSS23GPN1HIF1ARELAACAD10C1QBSEMA4GCFTRRTP4ST14GDI2BPHLEIF2AK4

Page 636 of 781Diabetes

BAZ1ATCERG1LIFI35BSCL2DDX51SLC30A5CYB5RLSOCS2GPR142C11orf24MBIPHLA-DMAITGA11IER3IP1NIT2KLF15ARHGEF17WSB2ME3GALNT11ZMIZ1TMX2SUDS3NESPOLR2CEIF3KMLXIPLENC1ARSEUBR2VOPP1STC2SAE1ANKRD34AMIOSTCF7SAMD9MMRN1AKR1C3SPARCMIR22HGMOAP1CTSZVTI1BSEPHS2TATDN1WNT5BSLC25A38

Page 637 of 781 Diabetes

IFT20MCF2L2OLA1FAM120BMAMDC2PDIA4TESCIGFBPL1JUNNAGKRBP1PLXDC1KIF3CCDH5DAAM1NEK3KRT40B3GAT3MBOAT2NPTXRTTC7BGPC1GLS2CCDC189TOB1MNX1CMTM7C6ABHD16APATL1SLC25A53RANGAP1SNCBTRIM50RNLSSPEF2KCNK16PDFTKTCMTM8PRADC1MPLHSD17B2UBE2G1ADCY7PPP1R14ASIDT1C1RL

Page 638 of 781Diabetes

GJD3PRKRAGYS1C15orf48DCLK3SLC4A8LINC00665BAK1RPS5TSC22D1SHC1BLOC1S2LIMS2RAB19ENTPD3GLT8D2IMPDH2INTS6SEC14L5GPR37L1SIX5SSTR2ZNF529ALDH3A2DDB2SPTSSADYSFSLC27A3NPC2YTHDF1DMTNQDPRFOXA2TMEM98THAP12LAMP3KBTBD3SORT1FAM98BNFKB2SLC25A35FAM76BQPRTUBXN4NPM1DNMT3BADRA2AEDRF1

Page 639 of 781 Diabetes

PDE4CLDHBLTBP1PLD6RASSF5SEC11CTMEM14CVTCN1PKHD1MAFAHLFITPRIPL2ADAMTS2AP3B1CDH24VAMP4PRRX1GPR119MED18HCKFAM189BCLDN9VWA2C17orf100PIEZO2IER3YWHAHTMEM170ANTMCNDP2BEX2YPEL5AGO2DSTYKAOC1THY1TBC1D8CACFD1ANTXR1ETV7SPDL1WNT5ARANBP1WBP11FAM78AH2AFY2CCNKWNK4

Page 640 of 781Diabetes

SGK2ZNF740USP18SLC17A4IPO5SURF4BCAS2TPPP3ANAPC1NFATC3EPSTI1TMC6DMGDHPCBD2RCN1BCAR3MDH2BCL6TXNL4ACEP68PSEN2ATP6V1E1ASB1TPST2ABT1MDFIPOU2F2NUDT16ZNF74SNX29HYAL2LRRC36ATP2A3ANGPTL1FHOD3IGSF21OLFM2B3GALT2CCDC74ABEST3KLHDC8ACNTROBINPP5FEMCNDUSP12CGREF1VIL1ZNF664

Page 641 of 781 Diabetes

SOGA1ZFP62TRPM7FEM1CSERPINB8IP6K2NXNZMYND19RALGAPBNAMPTVKORC1L1HS3ST3B1ISLROARD1CD99L2ATG2APPP2R5BRPGRIP1LDANCRFXR2TMED8MEX3AARHGEF28PALM3SLC22A15SLC2A6GBP1PSMG1BLCAPGNEMGAT4CTUSC3COPG2EHD4OSBPL1AZNF589F2RPID1DPF1NT5DC2ARSGEIF4EBP1C2CD2LFBP1HIST2H2AA3MFAP2SOCS1ST5

Page 642 of 781Diabetes

PHLDA2GGCTERLIN1SLC29A1GLRXST3GAL4REG1AFBXW7SLC25A36ZNF26CYSRT1TDRD6H2AFVSGCDLRRC20UBE2ZCOL4A1ISOC1STSFFAR2TP53SCO2ATP6V1G2MX1HNF1BSRA1PPIP5K2DYNC2LI1RABL2BCFLARHAPLN3ACACBFAM210BTRAK1GRAPRORCELMSAN1MXD1WDR37NUAK2SNHG1MANSC1MANBAIL1BNSG1RNF8PTPRUSIAE

Page 643 of 781 Diabetes

ZMPSTE24TESK2EIF1ADPCDHB5NOD2PRELPGYG1POLR3GLSERP2WDR13GAPDHMOCS2CYBRD1PARP9TMEM88PLEKHA6AMIGO2TMEM26EVPLPIM2SLC17A5PIPOXSOX18SERPINA10SYNGR1REEP2GINS2IFIT3RRN3MYO1BPLAUC1RERI1SETD2ROGDIUGGT1ACOT1RFX5TMEM204PTRHD1SLC22A4SERPINA6PROM2CROCCTGM2ZNF202SLC23A2SLC44A2

Page 644 of 781Diabetes

BIN3GABPB2KCND1RNF208ATF3NPHP1GDF6TAPBPLBTG1KLHL23PCYT1ASFR1CASP10COL15A1DACT3PCMT1HDAC5HLA-EATP1B1GSTA4USP49YEATS2TSPAN8RAP1GAPDCLK1SLC4A3STIM1PODXL2NTNG2HOXB3FRAT1DUOX2CFHTOLLIP-AS1METRNPPP2R1BJAG1CHGACACNA1BDCTN3SLC1A5MPV17LZNF639AKR1C2CACNG4ZNF527FOXO6FAM86DP

Page 645 of 781 Diabetes

ZDHHC24LITAFABHD15MPC1ELOVL7EMP1PFN2COG2TRAPPC2LDDX42C4orf19SLC27A1OAS3CTAGE6KLLNGSTO2PRKAB2INF2SLC16A9CD248TIMM10BGATAD1PIP5K1ARBM20ZRANB1FEM1AMYCT1GM2AETV4C11orf95SCGNZCCHC7TMEM9BDNAJA1ZSWIM8NUDT14RAB11FIP3KBTBD11SERF1BCYB561D2CNNM4IRAK3LIPACCSAPFAM220ATBKBP1PSG5CAMLG

Page 646 of 781Diabetes

RSAD1VPS37DGABARAPL1SLCO1A2BMP4ECSITRNF168GBADPY19L2CYYR1PNRC1TRIB1CIR1TYSND1TRERF1FMO1NANPBEX4TADA1MCEEDROSHAEMC7CCL2TMEM41BEFHC2SRP9ZBTB8ANFAM1PBX3ALKBH4EPHA1MTPAPLAMP5GZF1PHLDB1DACH2KIFC3ARSIZNF329MFSD6LARHGAP31ST3GAL2SYNDIG1MED4PTPRSCLDN15BRAPPPP1R12B

Page 647 of 781 Diabetes

MARCKSTTLL12NCKAP5SERTAD3SCFD2PSMG3TMSB15BBACE1OPTNMAPKAPK5DGKGGRASPMETTL9TFB2MSP100RAI1LAMB1HOMER2SMARCD2GPR27PLXDC2SLC7A5ATRAIDSLC35D3IL3RAEXPH5ADORA1CLINT1SEMA6CARRDC3TBPL1NINIFIT5HPCAL1PLA2G15PTGR1IFIT1FNDC5H6PDCADIRF5RDH12ST8SIA3C19orf48RIPK1ATP8A1PARP10RECK

Page 648 of 781Diabetes

RAB3IL1EIF2ASLC20A2TTYH2SMOC1RCE1SH2B3LDLRAD3CATSPER3HYKKBAP1ERP44METTL7ANFKBIBNSA2SLC46A1OLFML2BMRPS2POLR3HTMEM17ST6GALNAC6NMIRGS9STAT2ROBO2TM7SF3CYTH3CUL2KIAA0319PKMJAK3HEY2CXCL5ZNF667-AS1RHOBTB3PKDCCSYT17EPHB6KRT10TRAM2-AS1CNPEDN2CCDC121TTC17ARL15ABLIM3CABLES1ADH6

Page 649 of 781 Diabetes

P4HBC1orf127RAMP2ACTA2GPT2DDR1FKBP9ATP6V1DPDSS2SNRNP27NME3CHN1TMED1ANXA4TULP3ATICONECUT2SULT1B1FAM81AC3orf38DLEU1SLCO4C1CPPRMT7DNAH5CSF2RBIFI44ZNF358ERCC2CYP2R1C3orf67GPLD1EXOC6CTSC

Page 650 of 781Diabetes

Overlap total GenesT2D-BFA 3540 ELMO2

CREB3L1PNMA1SLMAPHAUS2SMARCD3ESYT1LMAN1DDB1CRNKL1XAB2RTN1KBTBD8SEMA4DINIPBANK1NR4A2LONP1PPCSCHD1FAHD1CMPK2SLCO2B1ABCD4TEKSLC25A46TERF2IPGRK5CA11ALDOCNUDT1ACBD3CEP350LOC100506098LGI2WDR45CNPY4ZDHHC6DUSP4RMND5BCCNYROR2ZBTB48BUD31MAOARFXAPCDK8RNF4PPP1R3D

Page 651 of 781 Diabetes

SYT13EIF1CETN3POLR2BGPN2GCC2PLXNA1CD82SETDB1LOC100287497PTP4A2HPCAMLF1TAF12THADAID1SF3B6CXorf56MTMR14ASS1TMEM59SEC23IPRGS4SNX6ADAM23NCDNTMEM104LRRC8AGNA11OGFOD2SDC2METTL21ASARSSETMARAHCYL2PEX16HABP4TMEM125UBN2ASNSD1UFL1HGH1TMEM11SLC9A3R1OSBPDNHD1FKBP4NADSYN1RGS14OSGEP

Page 652 of 781Diabetes

ARMC6PSMD5EIF4A3PRPF3CHMP2BCAMSAP1PIGLKIF19UIMC1GOT2KINPDAP1ZNF146MIA2MANFZNF487NENFTTC13CYP3A5AKIRIN1RDXDNAJC9JUNDMRTO4NDUFB8TMEM248SEMA3GSLC2A10OSER1PREX2KIAA0930METTL7BSNCAIPPECRHSPA2SERP1PIGGDPYSL4ZNF264RAB5ADCAF11SECTM1TCTALAMTOR5SQLEGLIPR2EIF5APLRG1ZNF614XXYLT1

Page 653 of 781 Diabetes

GRPEL2TLR5SAFB2PSMD12ERCC8TAF1DPCED1ADVL1CMKLR1PEF1ZFAS1ALG9BAIAP3DICER1-AS1RABGGTBCALCOCO2SPATS2LHRASGEMIN6LINC-PINTJAGN1RNF43PHF12SRRDPSMB8PPP6R2APOL1VAT1CCDC14MAST4KCTD2NR4A3ARSASOCS3TMEM132ACGRRF1MCATPIANPEPN1BRICD5WDPCPNIPA2MAGI1PCYT1BAUHEIF3HMBD2PIGTALAS1FOXO1

Page 654 of 781Diabetes

MRPL37KIF5CCRLF3PSMA5TSEN54CBX2CNOT2ABI3RBMXL1CRTAPDDX50STMN1CCZ1BMMP24CKS2RPS6KA2MROTDP1ZNF287DNAJB11GBA2FMNL1ZNF165USP38ARMCX3ARHGDIBNDE1CACNA1CFAM20BBRI3BPOBSL1SLC12A7RBM4BPPP1R15AFCGR2ABMFMAN1A1NKAIN1FBXO34RB1CC1PCDH12EIF4ECSDC2ABHD5TCHPBATF2SLC35F5ATP2C2CD276PIK3C2B

Page 655 of 781 Diabetes

SLC31A1IFT172COMMD1FOXN3TMEM182MFGE8RNF167PRMT5ZSCAN12P1DCAF4ETV3RNF126CEP63DPM1TNK1POLR1BSH3PXD2BSAMHD1SCG2SLC17A6PKD1P1NLKGNAI1VPS4BNDRG1SESN1FARP2ACOT11DZIP1GPR161WDR74PCNPNEO1MXRA7GLT8D1LATKCNA3FCF1SMARCA4MASP2ZBTB21CCNB1IP1TMEM43TTLSTAT5BENPEPSSBSH3D21SEC61GGLIS3

Page 656 of 781Diabetes

TMEM50BDBNDD1TBL1XR1SZT2G6PDNUDCEIF3JRTCAMFN1NRG3LPCAT4CAMSAP2ABCC5MOCOSFUT11MAP3K12ZNF121PIWIL2SYNE1CMTM4PSMG3-AS1WDR44HCG18BTBD18DCAF13BHLHE40KLHL31SLC26A2RAB22ASTAU1CRB3DDX21ZNF160BARX1DHX29MTO1LOC100996724SLC15A3TM9SF2ITGAXMTPNCANT1LIN9UNC50GNG7RUNX2CROCCP2MAPK11HIP1RZNF204P

Page 657 of 781 Diabetes

NAB1MED31RAP2ACRIP1AZIN1ARG2NOL7TSLPADAP2TAF8RNF139ADAM8RGS12LRRIQ1TOMM5C2orf68CHP1ACAP2ACP1LOC283177SLC2A4RGKIZHCN4FAM214BNPM3RARRES1ITCHMGAT3SLC2A2ADCY4SLC46A3PTRH2SSH3ZNF135TIMM50HDAC1CNIH1LMCD1MICAL1BLZF1SARAFRIMKLATOMM40MBNL1-AS1ADNPSNRPB2KDELR2ZNF570CTSOMARS2

Page 658 of 781Diabetes

SDF2L1HIBADHIGFBP3DEKPSPC1ALBAGBL2C1QAZNF703VAMP7SPRED2N4BP2L1PITPNC1HAUS3LIN7CFUT2STX6HIST1H1CPDK3TPRKRBA1HOXB7METTL17IRF9MCPH1SYNMHINT1CHCHD2DYNLT3FKBP11CHPFCSNK2A1RPL14TMEM208MAFFCCT6ARBAKARID1ASTARD7SHMT2NDUFA5ZNF251RPP38RCBTB2RBMS1HNRNPUL2-BSCL2SAFBRFX2ANKZF1SENP5

Page 659 of 781 Diabetes

CBFA2T3LZTS2ANKRD37FZR1MMS19GMPR2ST8SIA5LPPORC3EIF4EBP2DFFBHSPB6NMBEIF6AIFM1GSTA1SLTMSTARD4-AS1ARVCFRENBPC1QCZNF783ZNF85CLGNTFDP2POLIUCNFHL3SPATA5L1PELP1RNF41SERINC3EPDR1AKR1B10SLC39A14RGS16BCO2NFATC4TMEM60BMPR1AFUBP3MOB3CTMEM127YARS2APCDD1LZCCHC4ZNF669CDK12CACNB3THAP11

Page 660 of 781Diabetes

NEK4PRKAR2AATP6V0BSPATA17OSTF1PLEKHB1MRPL33PELOARMC1IDI2-AS1PON1HBEGFGNPDA1UGT2B15PGAP2FZD2PSMB6MRAP2PPP1R8TNFRSF11BGOLPH3PIBF1TNFSF15HSD17B11GABRR2URI1DHDDSNEFMAPOL4ANKRD28MRPL28SNRK-AS1RAB14PIGVCDK2AP2CHD3CD40GSN-AS1CCDC186GSAPIGFBP7ZNF609MED10EHMT2PACS2LSG1FBRSL1DMPKCBR4SMC1A

Page 661 of 781 Diabetes

IDNKNPPA-AS1TUSC2ENAHRCC2TMEM230ZNF543CD58EXOSC9ABCB1SSR3ITGB7RNASEH1-AS1DNAJC7CHKBACCSRRAS2LTBP2ZDHHC4PDE9ALEF1PEAK1SERPINB2PITHD1GTF2F2RNF113ANHP2MOCS3TMEM132CANKS1BMFSD2ATMEM47RPAP3EFCAB14PLEKHA3TMEM14ATCP11L1CWF19L1MYH3SULT1A1YY1AP1ARPP19RRAGAHLA-DMBEXOC8HLA-ASAMD1UBXN10SYNJ2WDR36

Page 662 of 781Diabetes

ST3GAL6SLAMF8ROBO1LINC01091INPP1ROR1-AS1EIF5A2CPMTMEM214DGKBGALNT12MRPL35TNKSCRLF1CDK5R2WASTUBKCNK1SUMF2TMED5CDH6AQRTHG1LGOLGA5CSE1LASRGL1ZBTB11-AS1TOM1CENPNTMED2C2orf76STYXATG13U2AF1PFKMCREBZFRIOK3GCHFRATG9ADNAJB6PPT1UBE2BRFC4BCL2L13CCDC30NUP50KAT2ACCDC130ARRDC4MTUS1

Page 663 of 781 Diabetes

CPQGTF3C2MR1MRPS30ATL3TCAIMMIEF1PRR14ZBTB6PRR11NUDT3SRSF8HMGB2PTAR1PRICKLE2POLR2DTOR1BMVB12BZMYM3CASP3CACNA2D3SUCLG1TMEM67WDR47PRPF40AMAGEH1CLDN12TUBE1DDX19ATMA16MOB3AGFM2PSG9ARHGEF11BTBD3PPP1R2UBXN8TUBA4AEEF2LRIF1SCYL2PEX2MYH14LEAP2GADD45GSLU7B3GNT3SAP130PCDH1NIFK

Page 664 of 781Diabetes

CAPZA1GLRX3CCR1NUS1PGRMC1DNAJA2ZNF512LYNTGFB3ELK1NAP1L3ADAM33COX6B1MAPK6NTMT1NUDT11PYGLNUCB2FOXO4ID4NOD1INARIN3MED17PIGANQO1TOX4HSPA9AXIN2ZBTB1TAF1GIMAP7AP1G2UTP3GRIK5LOC441204ORMDL2GGT7MOKZNF226KCNQ2HTATIP2LINC01137ING4AP3M1CORO1ACEP76ZNF460OS9COG5

Page 665 of 781 Diabetes

COPS8AKAP9GPSM3ENTPD3-AS1LDB2MRPS23PGAP3EFEMP2EFNB2C21orf62LOH12CR2NMNAT3NOB1TSG101CEBPGGTF3C4TNFRSF1BPATZ1PLEKHG6SMG5MRPL49ASNSISG20GJD2CASZ1GIN1TMEM177KRR1CDKN2AIPMRPL40COMMD3NR2F1-AS1LY6HLRRC59LARP1BEDEM1CDC73FAM43AGSTM3SCML1FBXW11SAP30BPWDR76MEAF6GPRASP1ZFAND3HSPH1SPSB3CDC16KIAA1614

Page 666 of 781Diabetes

ZSWIM5UBA2RBM18WDR5RANBP10MYO7AACVR1BDENND1CCIB1PPP1R16BCTNNAL1TLE6DRAP1SLC38A1ARHGAP6MYO1FSETD7RBM8AITGA9ZFRKCNB1CANXSLC25A28DESI2ANKIB1TMEM150AECHDC2SMA4PABPC1CUEDC1STARD9GPRIN3TSR1CCDC85ATMEM126BNDUFA9SCRIBEGLN3FBXO45TBCKEIF2S2RNF130UCHL5ULK3SMIM15PNO1RARSDSN1GPRC5BRASL11A

Page 667 of 781 Diabetes

KITLGSETXTTC9CMFNGFEZ2DLATTHSD4CDC5LLMNASRSF5SNED1WNK1GSDMDRECQL4PPA1GTF2H3C1orf116CALHM2TXNDC17TRNP1TRIM25CRKLZNF133NUDCD1PHTF2CHCHD4WACIWS1PCGF1PRKCQ-AS1MTMR11IDH3BGOLT1BALDH9A1SUSD1RASSF1LRIG2PAK2PRKAG1FCHSD1HLXLOC100507507C2CD4AGNL2PFDN2FBLN5KLHL24SGPP1ZNHIT6ZNF638

Page 668 of 781Diabetes

APBA1RAB2AGRAP2TACC2HSPB1INPP5ECOX7A2LITPK1CYP39A1RBM15AMZ2GDF15CYCSKIAA0895LDDX11IMP4ANKRD13BNDUFS1ARRDC2CD2BP2TOP3ANDUFAF4CERKGOT1CASP6RCL1PIKFYVELRRN2B3GAT1NOC4LPOLR3KATG2BARL4AGPR153DAD1HSD11B2CAND1ACTR10NASPAPOBRKPNA2TMCO3GNASKATNB1BCLAF1TRA2BGLE1DHRS7GTF3C3GTF2IP4

Page 669 of 781 Diabetes

ALDH18A1TPI1DNAJC5DAPK3EMP2SRSF6GJB1POLE3RIN2ATAD1USP7YME1L1TPCN1PCBP4CDH10SONMZT1PSMD3BCAMC14orf132PCK2HLA-DRAEDNRAEIF3MZNF24FUCA2HHLA2SMAD9USP19LSM12GDAP1L1NUP88CD300AMOB4DHX16SLC35A5ARL2BPTTLL11CCDC18NGDNSTK40AGGF1PJA2PHF1AGTRAPSTON1NDNFFBXO36MTRMLIP

Page 670 of 781Diabetes

TPMTZNF672PLXNB3ACVR2APGM2L1OPA1TMEM140PRPF39DISC1DZANK1CLTCL1CCL26CCDC6RASSF4MTHFD1SEC63TOR1AIP1PAFAH1B3CTSBSIRT2MEIS1BMP8APSMC4TUBA1APSMD8RARS2MAP1LC3BP2RY8CYB5R4KRT8C1GALT1C1FDFT1PTGS2UBE2D3SPIDRLRP5ARFGEF2MAP1ANELFCDEME2NAV2ENTPD2ADH1CCNOT7NKAPEAF1LRRC61SLC30A7S100BPGGT1B

Page 671 of 781 Diabetes

KCNN3DPY19L3SCCPDHOLIG1CDK4OLIG3EDA2RLOC101928907DENND2AKAT8DMXL1RBM3DMTF1GRM1SCFD1IBA57GAP43PDE3ATNFRSF10CRASGEF1ANTPCRXPOTTRIM14ABRACLSLC7A11DERL2FHL5TINAGL1FHAD1NAA15ORC5TMEM259PTGIRACAA2GLCEFCMRTSPAN2BROXCTSFFBXO25CHD1LTRMT11PTTG1TMEM62SSBP2HABP2REEP1FBXO15CHMP4CRGS1

Page 672 of 781Diabetes

PLXND1TEAD4DTX4TIMM8ATRIP11POT1MMP11MYO1EUCHL3LRFN4GREM2CCDC102BHDDC2MTUS2DBPCOL5A3HEBP1LUMUBASH3BKPNA4GLO1WDR61ZNF835DYRK3HNRNPDRBM34AAR2PLD2PALMPUM2CMSS1ARXANGPTL4HHEXEMC2ACOT13INSM1GLRA1CTNNBIP1HMGN2TBCELIASGADD45ATMEM70SBF1PPP3R1USP46SPI1DCAF6OXSM

Page 673 of 781 Diabetes

SF3A1COPEEIF3ACOA4YRDCKIF12BLVRARASL12CASC15BOKPGAP1FSCN1UBAC2SIRPATSC22D2TYW5ARHGEF15RAB3GAP2UFSP2HSPA14BRD7DTYMKSLAIN2QTRT1CCNT1WDR53CD74FEZ1SLC35E1LAD1MAPK8DNAJC8HDAC8SRP54NRGNDNAAF2VAMP5SYTL2LACC1MTFP1UXS1GTF2BSLC43A2GUSBLIG1COPS3NID2LSM8ZNF616MRPS16

Page 674 of 781Diabetes

TCEA1SUSD4WFDC2SETD1BSSR1OSBPL9NUP107PDE4BCCDC87MAPRE2ARFGAP3MAFBAK6TMEM14BGFERTNNI1DNTTIP2GOSR2DDX1LCP2VPS54PEX5UNC80SDE2MCUR1MED24PDCD1IMMP2LAKR1C1BRD2CATSLC7A1AGAP3TPM2OLFML3ELAVL1GCNT3ABCA2PITRM1STXBP1ADMLSM2PRKACAPPP1R1AKATNAL2RAB1AWDR90SHISA7KMOWHAMM

Page 675 of 781 Diabetes

USO1ABCC1LMF2PCBP2MUC13MFAP1WIPF1MMADHCRNF181SNTB1SLC24A3UBE3ASNRNP200ITGA7ZNF252PZFAND2ALRRC57WDYHV1SEMA6BMORF4L1ENGASERRP15GALNT1RSL1D1SBNO1ANKMY2ADNP2ARCN1IFITM1FBXO28TSHRGSTM2ERGIC2NAT1MTCH2PGS1HAP1EPHB2COL27A1CCDC78NME1SYT16ANKS3SRRM2CAAP1POLA2KCNJ8NOL10RANBP9EVL

Page 676 of 781Diabetes

LNX1NUDT21ERC1NKIRAS2SCO1PDLIM5C1orf43TMEM54LETMD1PHF23B3GNT2EYA2S1PR3CKAP4PITPNM1RNASEH1OATACTR3CHYAL3SMNDC1SLC30A9PRCPYIF1BFAN1TAF5LCCDC59MED20LINC00884TOMM20COL22A1GTF2A1AGFG1MRPS35MSCPROZSEC23BDCKSPTLC1HMGB3TOPBP1HOMER3KLF11KCNAB3EXOC5GKUBE2E3METTL8SLC39A7PRDX6ILF2

Page 677 of 781 Diabetes

ASCC3DNAJC22TMEM18PIGZCRLS1CYP2U1CSGALNACT2PLK3KDM5CRSL24D1UBE2FDAP3ZC3H7ASSBP4KLF16MFAP3ADAT2PRPF19LDLRAD4RPA2NABP2ULK1FEM1BKIF5BUHRF2NUP153CENPHCLPTM1ELF3NUDT7GPIRAD9AFAM135BE2F1KLHDC7BGPATCH2LRAB11FIP2TSC2NRP2CPSF7MROH7SPTAN1TENM2LOC102724814ISOC2PRDM4HSPA4DHX40RRP9RAB26

Page 678 of 781Diabetes

EVI5IFT80MYL6KCTD5EPB41L1DYMTOM1L2RAB21RPS19BP1KIAA1549LZNF343CORO1BMAP2K6ZC3HAV1YY1SLBPCKS1BSLC19A3CDC37L1FESTTC25NME6AP2M1SNAPC4SLC9A7FAF1P2RY1AKTIPFURINUQCRFS1SMIM12EDN3BLMNALCNGMIPSF3A2SMAD7FHL2RRN3P1CDC42BPGPSMB2WARSRGL3LMO2PDPRPTK7PPP2CBDOLPP1CYC1EPRS

Page 679 of 781 Diabetes

CHUKHRTTBK1GPN3TTC39CTHOC1KXD1INTS10ZNF124NICN1SPRED1AP5M1RAD51CPARP6PRPS1DRAM1CXorf40AFRAT2MCHR1ZNF101MPHOSPH8LRFN2TULP4PAPPA2STK33OSTM1NAPEPLDDDA1STRAPCBX8MTMR10PRMT6NDUFB6FKBP1BMRPL17CENPBD1P1CXXC5VAV2TP53BP1ERCC3TFRCTMEM80DDX46AK2CMTM6ARAP3NIPAL2CSNK1A1CCNCCHKA

Page 680 of 781Diabetes

DHRS3IQCB1SPATS2COA1SKIV2LATF4ZNF829RAPGEF4FUZZNF696FAF2PDCD10ACADSMKRN2ENKD1PSME4TFGANXA5KARSATF7IPETF1HHATUBE4ACCDC68SEL1LDUOX1TRAPPC13EIF4BBTF3L4DDX55GOLGA7BLOC1S1CD34STX3ACYP1ENGGAPVD1PHIPSLC11A2NIP7TMEM158COLCA2SS18CARM1ARHGEF37CBFBDPP3TUBB2AYPEL4ZNF276

Page 681 of 781 Diabetes

RBCK1PLXNA2LONRF3COPS5TVP23BHERPUD1SCPEP1SLC36A1LOXL2DENRSENP2ADPRHRAP1BPRKG1P2RY6NLRC5CYP20A1SORBS1PEA15NDUFAF2PACSIN1FNBP4WDR25GPR4SGCAGALK2DCAF15RAB3BZNF451CYS1ZNF286AZNF302ENY2CALUANKFY1DENND3CMPK1RWDD1SLC18A2ASIC2GNPNAT1ZNF526DDNELOVL6EPHX1PPIL2GJB2RAPGEF3LGALS9SCARB2

Page 682 of 781Diabetes

MAPK3USP34ADKTGOLN2CTBSFGD1EDC4MPZL3HOXB6STAP2TRIM44PARLSIDT2RYR2TRIM32PTSATP6V1G1ADCY6DDCGLRX5TTLL3PIP4K2CWSCD2TSC22D4STK35CCNHUSP48APOBEC3CRUSC2RAD17ZCCHC8CD5CYP26B1CMBLTMEM163VCLFYTTD1SERPINE1IRGQRAVER2AKAP5EDARADDCREBRFLRRFIP2PLLPRNF121BCCIPOXSR1MESTRBBP5

Page 683 of 781 Diabetes

ANGPTL2HBS1LTMEM30ANCAPH2CRKNEDD9RNASET2LOC101928504ETV5BTBD7S1PR5GSTO1CORO7LSM1UBIAD1CDC42BPBCAPN10PDLIM3ZNHIT3SNRPD3UNC93B1SPCS2PRKAB1RPUSD4IRF8SS18L1ITGB3MAP7D3ARPINRBM27WDR55HEPACAM2CERCAMGIPC1ZNF770FZD1LAMA4ADPRHL2NDUFA10RNF13PAXBP1-AS1ETNK1CEP44TEX30CLNS1AZXDBUBR7CHAC2CAPN7RANBP2

Page 684 of 781Diabetes

TTC9MLPHZNF557TGFBIDDX41UBE2D2PGM3ZBTB49MARVELD2DHRS4-AS1OGDHLHSPG2SLC52A2DUSP9C21orf58NANSATP10BFUNDC1MISPGRIA2VDAC2LMBR1LANCL1PCNTSNX21BET1SNX17N4BP3ZNF622PCDHB15KCNMA1GNL3ITGA5BTG2VPS4ALRRC41ZNF646IFT122LRRC6HOMEZMSL1CPXM2HS3ST3A1MON1BCHORDC1TRIB3ANAPC4ZSWIM1LOC93622KCNK3

Page 685 of 781 Diabetes

COX15KCNK6MREGAK7PDLIM2PHYHIPCOPS7AIGSF3LRRN1SLC25A14CACNG5UFSP1ACTR8RABGGTATMEM19STX8RUNX3LUZP1EFNB1A2MGRPEL1CCDC66PPP1R15BTRPM6FEVSLC8A1DGUOKLINC01138C1QTNF3SUPT4H1TRAF5MFFFAM98ASTAU2EXOC3RAD23BMFSD8PODNTIAL1UFM1USP14ING5HTR7P1KIAA1211LHSPD1N4BP2L2B3GNT7CCDC43OPHN1ADH5

Page 686 of 781Diabetes

DESI1PREPCHMP1BSYT12COPS4MAP3K13LCMT1TJAP1RNF139-AS1KIAA1324PXDNA4GALTTOMM34CD6PSMD11ZBTB11B3GALT5SAMM50CDC42EP3SRP72TSPAN7MFN2ATRDDX49THAP1DPYDDOHHCROCCP3MAPK10KDM2AMED27GLIS2NFIL3GCACLDN6EPHA4CENPUGPATCH2ZNF655MRPL15RPUSD3QRICH1MAK16TSNLZTFL1XPCGMFBAGTPBP1STAT5AYIPF2

Page 687 of 781 Diabetes

TRMT6PTPRHRTCBCOQ10BPSMF1NFE2L2SH3PXD2AOPA3TJP3MICALL1TNFAIP6GGNCCT4RTEL1BRD4NDUFA13MTMR6SCAMP3SOX9UBTD1TNRC18FAUPACSIN3SVILPHB2NOXA1ADCY3DLSTATP2B2NECAB2LXNEIF3DSIX2TNFAIP8L3RNF7SNRPCKLHL28FAM193APCDHGA10LAMTOR3EIF2S1RBM7TERF2CD8AGTF2H5ZBTB8OSHBP1ARHGAP25ZNF710ATP6V0A2

Page 688 of 781Diabetes

SDHDIMPAD1PPFIBP1BCL7AKIAA0753FIS1PPCDCCD83GCGRBEGAINSLC35B1KDM6BANP32AMGPACLYDNAJC1CYP4F12MAPK7NUDT22SYNGR4GCH1FLI1PPDPFECHDC3GPRIN2ZBTB47ZNF681HMBOX1GPX2KMT2BRABAC1PTPN4ITGB2ERHLOC100506990CSRNP1SETBP1SENP3NSUN5SF3B5VCPGPR160BGNAPOBEC3FSLC11A1RALBPCDHGA4ATG3ADAMTS17KLHDC2

Page 689 of 781 Diabetes

MMP1PPP4R1GCLCSEC61A1CDC40GTPBP2SETD3MKKSTP53I3EBPEFR3BGPBP1ADAMTS12PES1UCP2PABPN1ASPNKCNH1QSOX2URB2YBX1AAASMCF2L-AS1MTF2FAM3CKCNH3DBH-AS1AP1S3GOLGA7BZNF84CITED2STARD8SIAH2RMND5AZFAND1SPAG5F13A1ACADMDUSP3FAM8A1ZPR1SDSLHACL1RAD23AFAM83BGHITMBLMHMYO9AADCYAP1RTN2

Page 690 of 781Diabetes

IAPPAPI5SHQ1C5orf51ADHFE1PTBP3TRIM4SERPINI1MMP14FASTKD5BIVMKLHL15DHRS12ZMAT1TNPO1EEF1DSNX5METTL6SOD1PACS1CDK13CAPN2PUS3LRFN1CHD2FZD5ZNF763ABCB9TRAK2STAB1ASPDHSTAG1GIMAP4DBILPIN2PDP2APOOLRPS6KA4BBS4MPHOSPH6ZBED9TTC39BPSMD6TMC5PLEKHB2C2orf72D2HGDHMPP6TCERG1APOLD1

Page 691 of 781 Diabetes

TOM1L1ROBO4ARMCX1CMASSNAPC5TNFRSF21KLHL18SPATA18WASH5PC16orf72HIST1H2ACCDK7SSR2GAL3ST4MCM2LINC00865CEP192IFT88ID2PWP1JMJD1C-AS1PCDHB9PDHXCLCN3ZER1PPP2CASEC14L2OGFOD1POTEMSNAPC2CATSPERBPEG3GALTABHD10SLC35C1RSPRY1UBE2AMAFGC14orf119JUPTMEM41AMAMDC4PDIA6DCXRCDC23PBXIP1CXorf40BRAB11FIP5EFCC1NCK1

Page 692 of 781Diabetes

SCAF1ZNF550MTERF3MIS12CUL7EIF2B1GSTZ1HS3ST2FAT1NREPFAXDC2TBRG1STAM2ADAT1TMEM50AGTF2E2TTC14SH3BP5-AS1CCNFKLHL5NMT1DLG5PGM5ATG12SWI5MIA3SEMA3FSLC27A2ZNF789ARHGEF25ZNF404NSMAFSKILWRNIP1CNOT3ZNF821GAKCRTC1CPT1AALMS1LMO1C6orf226EIF3ISUCLG2MLH1AMPD2NRBF2PDE1BMCM3AP-AS1DOCK7

Page 693 of 781 Diabetes

TMLHEZNF391ABCC8BNC2WDR3TTC33STMN2KLHDC9SAMD4BFAM13BATXN2LNARSSMAP2CALCOCO1AAK1UBR4PROCRNDEL1BAATTMEM37MBD1WDR73ARFGAP1BTAF1UQCRC2HYAL1GNB3HMGB1HOPXZNF519METTL1CDC25AESM1ATOX1KANK1KIF26BRNF122SLC22A18ASSEC24DCHRNEMDFICNUFIP2MTA2MAATS1ID3TM9SF1ZNF473IQCKCAPN3FOXQ1

Page 694 of 781Diabetes

GNAI3CD4UNC5BSDHBSOX4CALB1DERALAPTM4AAGAP11KIAA1522DIAPH2ACVRL1CRY2RXRAPDLIM7ALKBH1CLDN11CIB2MXRA8HRKRGS3RAC2SCOCRALYNAPGPLCG1TAGLN2MDH1YTHDF3DPH3RPL7L1PGRMC2MEIS3P1TBC1D5MYO6GLRX2ARL5BTMEM223SLC25A5MYO1CKIFAP3HSPBAP1CSTF3SOD3VWA8COMMD2WIZALDH4A1LINC00511SPRYD4

Page 695 of 781 Diabetes

LRRC58COPARASD2ZNF175TRMT112KIAA1143ARF4ANAPC13PPP6R1MBTPS1SH3GLB1HMGN3USP16ZBTB2PLXNB1ALG14PI4K2ATEX261CLDN2ZMYND8PDXKGATAD2AIFFO2ARHGAP33ZNF721SGIP1EMG1HIRACOLGALT2ITGA8PRKCDNDUFB4TP53INP2GLB1LNPSR1-AS1RBM19TAPBPALX3ZNF765SNX10DBF4POGKPPTC7GLP1RTRIM37GRSF1ABCC4ZFP36L2MAGT1DYRK2

Page 696 of 781Diabetes

ARIH2ANXA9PIK3C2ASRRASPHPVRIGEARS2SH3BGRLPITPNAPRPF4BGJA4TRPV2BHMT2CHL1P2RX6TBC1D2BALG13ZBED5-AS1MPV17L2TMEM8BSMARCA5PLEKHG3PLS1GLB1L2SENP6VEGFCLARP1DBTZBTB16PDGFBSUMO3LGALS3BPMRFAP1L1SPRABCE1SLIT3PEX13RWDD3YDJCCACUL1NR1H2ZDHHC12SPHK1TMUB2NEK1UBA3NDUFA4FAM222A-AS1DUSP1STX7

Page 697 of 781 Diabetes

ADOCDC42EP2P2RY2MRC2LRPPRCRRS1SNX2TSNAXZBTB7APCID2EDF1LTN1BLOC1S3PARP2NDFIP2ZNF134SRGNEIF3FEDEM2CCNJLE2F5PRUNE2LHFPL4SMAD4SLC4A7GNL1SCARB1DHX34PRKAG2ERVK13-1CELF3H2AFZPLK4NUMBLGOSR1DRG1SPCS1SRP19RNF5MFSD1PUS7LRNF138DYNLRB1SEPT5-GP1BBMAP4K5CHODLPLAASEH1LSHMT1ZRANB2

Page 698 of 781Diabetes

TRIP13SRSF4CPED1CDC7SNX7MVPLYPD1CUL1TNFAIP1ACEDUSP11SRCIN1PPT2FOXP4GNL3LGTPBP8MRPL18CHCHD3INSIG2PCDHB7DFFAPRPF4TYW3OSTCTMEM51MRPL32TTC31LSP1CDK9CD59EXOSC1LINC00674MRPL3BMPR2EAPPGCC1TIMM9FRMD8MGAT2OR7E47PSNRPA1TAF13OR7E14PEIF5AIFM2UBL3NLNPOLR2KHNRNPFPREB

Page 699 of 781 Diabetes

LOC100130691NME7FFAR4GTPBP4CICPIK3CAC16orf91GK3PKDM4CDAB2IPZFC3H1BRI3SDK1C5orf66ATP6V1HHNRNPDLKIFC2TDGXPO1WDR35MED1CXCL12IDI1ZDHHC5OPRD1SACM1LOXGR1FEN1CAPRIN2SF3B1ALDH1A1HPRT1RNASELZNF256ABCD1ACAA1SPARCL1FAM32APRSS23LOC101928100PSMB5USB1EXD3GPN1SGMS2MON2HNF4AFRKRELAACAD10

Page 700 of 781Diabetes

C1QBTXNDC9SLC41A2KHSRPEP300-AS1IBTKCAMK1DGDI2MLF2ERFBPHLMTCL1S100A10LBX2-AS1SUPT20HMRS2TCERG1LDPP8ACTBTRMT12DDX51SLC30A5ACVR2BZNF185SUFULMO3UBQLN1ZNF587CYP2C8UBA5MLH3DNAJB5COPB1PRELID1MRPL21HLA-DMAMETTL4NFX1SLC35A3PAICSTOMM40LARHGEF17WSB2CHD5GPD2CDV3CHST5LYRM4HIPK2DAP

Page 701 of 781 Diabetes

AKT1RPGRTMX2FAM107ALINC00537SUDS3CAMKK2TBC1D2POLR2CPON2EIF3KTCP11L2MLXIPLENC1MAP2K1PTP4A1GTF3C6ACOT4STC2SAE1YIPF5TCF7AKR1C3YKT6UBE2V2MOAP1LOC100506100CTSZPLEKHM2FICDVTI1BCES4ASEPHS2TATDN1PRICKLE1KHDRBS1SLC25A38IFT20MEX3CSSBP1KPNA6SUPT7LTESCYTHDC1AGMATCSF1RRBP1VTA1PLXDC1POLR3D

Page 702 of 781Diabetes

KLHL3FGD6C2orf16NDC1GOLGA4TMF1RPS6KC1PINX1SCML4NEK3FOSL1ATG14B3GAT3GPAT3TRAP1USP1NPTXRSAR1BTTC7BGPC1TOB1MNX1ABHD16APTGISPPIL6PATL1KRT23MAMLD1ATRNRANGAP1SNCBPDE12WDR63SPEF2RNGTTIFT52GOLT1AMMGT1TKTPMPCAGLTPCSPG4FAM214AUBE2G1FRAS1PRKRAMITFCSTF1FNBP1LSLC33A1

Page 703 of 781 Diabetes

PAPOLAAATKNDUFAB1LINC00665MRPL45BAK1COX6CGPR143ZNF576TMEM39APCSK1PCYT2TSC22D1ELOVL5B4GALNT1S1PR2ITM2BGINS1PAPSS2CLCC1ENTPD3SMOSDAD1GSSSIX5TAF5ANLNRHOCDDB2SPTSSAMKNK1ALKBH2MTRRSLC27A3PLEKHO1RING1TRUB2MSH6HECTD2FOXA2SLCO2A1PRDM16ULK4LAMP3FABP5FAM98BYWHAQPPM1KENOSF1MCU

Page 704 of 781Diabetes

NFKB2TMEM120BGHET1TRAM1RHEBNPM1ADAM19PRPS2FLJ42627TASP1EDRF1CCT8ZNF334LDHBBAMBIMRPS12CRIPTMAPRE1LRRK2ACOT7LIN52TMEM33POLDIP3PLD1CDC6CHI3L1WDR62UBXN7RARBZNF320IMMTCNOT6HLFITPRIPL2ADAMTS2ARPC3BRD8WDR12TCF4NKTRARHGEF38TBC1D9BCOLCA1AP3B1RPP14TIAM1CDH24PBX1VAMP4PHACTR1

Page 705 of 781 Diabetes

BCAP29ALYREFIQSEC2PRRX1ACSF2MED18ECE1SNNYIPF6GABBR1LSM3SSRP1ASXL2DEF8SLC17A9A2M-AS1PIEZO2IER3YWHAHFOXL1MOSPD1DDX39ATIMM17AHNRNPA0NSD1AMMECR1SEC13RBM26AOC1BRSK1TBC1D8CACFD1SCN4BSPAG9HAND2CREB3ETV7RASSF10MED25GPATCH11FDX1IL13RA1EIF2B2SPDL1ZNF593LENG9RANBP1CSNK2BSLC7A4WBP11

Page 706 of 781Diabetes

ANO10CCNKRNF150GAS8CD200GAD2CCND1USP35SGK2NOL11FAM122ANET1TOXIPO5IKBCAS2GIGYF2CEBPZCLN6APTXFASTKD2POFUT2PRKACBTMC6DMGDHRIMS1SPRYD7MDH2TXNL4ARAB25ZWINTPAK1IP1ENPP2PITPNM2TGFB1SLC6A16CEP68MRPL11VPS53ATP6V1E1SAR1ALCMT2EGFEM1PZDHHC8P1YES1ABT1MDFIASAH2BPIP5K1CANAPC10

Page 707 of 781 Diabetes

LRRC36SLC2A1RPH3ACTTNBP2ZBTB24ANGPTL1CCDC47SMAP1FGD2SRRM1DOCK6GLCCI1ABCC9SNAP29EI24RWDD2BHERC1INPP5FCRADDEMCNDUSP12PDZK1IP1COPB2CTR9ZNF767PCOPS6SOGA1PSMD9SRCAPGFPT1HMOX1FAM207AMRPS10INSKMT2E-AS1SERPINB8FEM1CIP6K2EXT1RCOR1PPIHPRKCZFOXJ3EIF5BRALGAPBPIGHGTF2H1FLCNNAMPTSSBP3

Page 708 of 781Diabetes

ZNF582GDNFAMFRMPHOSPH10PGFG3BP2TSC1DKK3OARD1UTP18RCHY1RBM45IGF2-ASSPTY2D1OSGIN1SEC24BDANCRTYK2ADAM28TMED8MEX3AUNC5CSNX9NECAP1CSGALNACT1TRIM52PDX1ARHGEF28SAMD11RIOK2STX18CCPG1SLC2A6TTC8PSMG1ZNF408BLCAPGNETUSC3SLC35A2IARSARFIP1CTPS1TRPV4NCKAP1LSYNCRIPELOVL2LINC00115F2RNIF3L1

Page 709 of 781 Diabetes

TRA2ATRNT1MAP2K7TMBIM6BMP1TMEM38BMTDHARSGZCCHC17SLC25A20RSBN1C2EIF4EBP1VARSFUCA1MPP5GALNT14LINC01089PHLDA2ANKLE1GGCTCOL16A1ERLIN1COA7SLC29A1TP53I11ST3GAL4SHOC2FBXW7SLC25A36DDX10YIF1ASNF8TDRD6HAT1H2AFVSGCDIFT27KRT19LRRC20UBE2ZZNF106ISOC1SLC39A8STSALDH1A3SCO2ICA1EPS8L2ATP6V1G2

Page 710 of 781Diabetes

MNTENTPD1PRPSAP2STK11SH3BGRL3LOC100128288YARSSUCOPPIP5K2ZNF469DYNC2LI1RPS6KA1ANKRD53CTAGE11PMRPS15KIRREL3GORASP2ADAM17ALG5S100PBPUSP5LZICACACBFAM210BAGPAT5PREPLRABGAP1LEIF4HRORCRAP2CGRAPETFBELMSAN1MXD1WDR37BOCSNHG1SSTR5-AS1RBM39TIMM23BRPARP-AS1SIRT1MANBAHAX1ZKSCAN3COQ4C5orf22INPP4APTPRULARP4

Page 711 of 781 Diabetes

ZMPSTE24ZNF503-AS2CPT1CEXOC7GRIA4IDENOD2GYG1R3HDM1WDR13GAPDHTRIM16LSLC39A1SNAPC3LIMK1AKAP11LOC100310756SULT2B1RGS7BPPLEKHA6C8orf33MAP3K11ACOT8CLASRPGPS2TRIM36RALBP1TP53RKEVPLSLC17A5SYNGR1ARL8BSATB1SMIM13ZFATLOC389765SYAP1AP1ARMYADMDERL3MTFR1RRN3RNF135TBCBDHCR24MYO1BARHGAP11APLAUCTNND2ERI1

Page 712 of 781Diabetes

ROGDIRFX5NDUFA6PTRHD1SYNE2NDUFAF3VCPIP1ARL1KLC4CDK5RAP2EIF3BAK3COX14GPR162GJA1SLC25A26CROCCSTAMZNF202ACTL6AARHGEF7PKD2LIN54CLCN6ATF3NPHP1DAB1TTLL6RTN4RPUSL1MIS18APSMC2PCYT1ALOC728392CASP10GPR173CACHD1PCMT1VAMP1SLC25A32GON4LSWAP70GSTA4CDKN1BUSP49STEAP3JTBPQBP1THBS3CEP170B

Page 713 of 781 Diabetes

SLC8A3TSPAN8MUC1COPG1MRPS17MYH9ZNF836TAF2SLC4A3HOXB3MORN1DUOX2APMAPARHGEF2PRKD3CFHTOLLIP-AS1MAU2NOTUMPLCH2PPP2R1BJAG1CHGADCTN3NT5CSLC1A5AKR1C2C11orf58SUN1SMC4SMAGPFOXO6FBXW2ZW10TUBA1BC12orf29CEP162MPC1PPP3CCACTR6PFN2COG2TARSTRAPPC2LMTORNR2C2APKCNB2C17orf75AOC3C4orf19

Page 714 of 781Diabetes

MTHFD2SLC27A1OAS3LIMA1ZXDAMORF4L2GSTO2PRKAB2INF2UBE2MRAD51-AS1LTB4R2FKBPLCD248DRD2COPS2GATAD1SUGT1HIGD1ASNRPD1BZW1PIP5K1APCNARBBP4ATG5ASIC1FEM1AMYCT1SCGNETV4TMEM9BDNAJA1ZSWIM8ARMC7NUDT14KLHL35GFM1PSENENRAB11FIP3CYB561D2SIPA1L3MEGF8CCSAPLIPAFAM220AMRPS22TBKBP1RSAD1TPM1PDS5B

Page 715 of 781 Diabetes

LINGO1DHTKD1ZNF644FLNBNRG2VPS37DCRTC2SUGP1SLC12A9TXNL1RNF168ISG20L2DPY19L2UBXN2BPRDX5PPIAMED6TRIB1UTP14AERICH3NXF1TUBB3SEC22BTESSH3TC1GRIA3FMO1POLR3CNANPJOSD1BEX4TBL2RPS6KB2SCGB2A1RAB31MCEESTAG3L3LAMA5ABHD17CDIS3L2ARNTLEMC7CCL2KPNA1TMEM41BS100A11CLTCSRP9EIF2AK3PBX3

Page 716 of 781Diabetes

NXT1SEMA6AHSD11B1LPSMD14EPHA1GAR1MTPAPRPF2EIF4G1C1orf109LTB4RISYNA1LSM7IDH3ADNAJC6SLC35A4KIFC3ARSITAX1BP1LOC100132057ARHGAP31UHRF1BP1LMSL2SYNDIG1ODF2EPB41IKBIPPTPRSCOTL1BRAPZC3H7BSOCS7RFC2PPARANCKAP5KRIT1FAM83GSCFD2PTPRDANKEF1MOSPD3PLK2EIF1BOPTNMAPKAPK5ZFP91TFB2MLIME1RAI1LINC00899

Page 717 of 781 Diabetes

ADM2ZNF229EPN3HOMER2WIPF2SUV39H1ATRAIDTRIM13SPTLC2SRSF10IL3RAEXPH5ANKRD13CSYMPKADORA1CLINT1SEMA6CPOLE2TBPL1ARRDC3DDIT3IFIT5HPCAL1PTGR1CNTRLSAP18CREG1HSPA5ZKSCAN5H6PDIGDCC4IRF5ACAT2SASH3RAB29EEF1E1MRPL2KHDRBS3MICAL2MTRF1LCOL14A1PRR15CPNE3ATP8A1PARP10ANKRD50RECKABATRBM47RAB3IL1

Page 718 of 781Diabetes

EIF2ASLC20A2SLC9A1SRPRBTTI2DNAJB9PAFAH1B2WBP2PRPF18CD81SLC30A6TMCO1LDLRAD3NIPAL3FGFR1OPMED28HYKKCEACAM7GOLIM4ADSLDR1ERP44TMEM144METTL7ANFKBIBNSA2AAGABPA2G4ABHD11KLHDC10TSPAN1B4GALT7UBTD2EIF2AK1MAP1BCUL9STAT2OXNAD1PDCD11OSCP1LLPHCYTH3MLECZNF337PROX1-AS1HMMRCUL2JAK3ARFGEF1CXCL5

Page 719 of 781 Diabetes

ARHGDIAAP1M2CETN2NOLC1IARS2RHOBTB3PEX11APKDCCSYT17KLHL17FAM114A1KRT10SERINC1PEX19TRAM2-AS1CNPEDN2PSMD7CCDC121TTC17ORC6POMT2MRPL16C3orf35ABLIM3C2orf42PSMC3CABLES1TUBGCP6CERS2RAMP2PDZD4ZNF330TXNPLAC8LGALS8ATP6V1DPMEPA1ZNF436SYNPOC6orf47TRIT1PDSS2SNRNP27DCTN5NME3NMD3CHN1C18orf54PMM2

Page 720 of 781Diabetes

TMED1REXO2DCP1BUAP1DHODHATICONECUT2ADAM15LGR4GAB1PRSS53SULT1B1SNAI2JPH3GPR39LRRC14MSANTD2USH1CMAL2NDRG3RNF6CACNA1IARMCX2ANXA11ZNF358PHF21AFAM49BPPWD1PNPLA2CNSTEAF2CCDC9LOC645513C3orf67GPLD1RAB8ADHRS2EXOC6PIK3IP1SLC39A6CTSC

Page 721 of 781 Diabetes

T1D T2D BFADataset 1 Dataset 2 Dataset 3 Dataset 4 Dataset 5 Dataset 6 Dataset 7A4GALT ABCC8 A4GALT A4GALT AATF ACSL3 CYB5D1A4GNT AGBL4 ABCC8 A4GNT ABCA5 ADI1 GOSR2ACSL4 AIG1 ACAP3 ABCC8 ABCA7 AOC3 SLC35E1ANGEL1 AKT3 ACHE ACBD3 ACAP3 AREG ZFPL1AP1B1 APOB ACO1 ACHE ACCS ARFGAP3 GOLGA3APOH ARF5 ACPP ACPP ACSL4 ARHGEF11 MAFBARAP1 ARL15 ACTR1B ACTR1A ADAT1 ASCC3 BSDC1ARF5 ARL3 AIG1 ADAM10 ADAT2 ATP8B3 MAXARHGEF10LARSI AKR7A2 ADAM19 AGPAT4 B4GALNT1 BET1LB3GALNT2 ARV1 AMIGO2 ADCY3 AGRN BHLHE40 PNPLA8B4GALNT4 ATP1A3 ANXA13 ADCY6 AGTRAP C20orf196 ALKBH5BACE1 ATP8A1 AP3B1 AGRN AJUBA C20orf96 BLZF1BBS2 B3GALT4 AP3S1 AGRP ALB C2orf76 GOLGA5BCL6 BACE1 AP5B1 AKAP9 AMFR CDC6 LAPTM4BC1QTNF3 BAG5 APBA1 AKTIP ANAPC10 CNTNAP2 COG6C20orf96 BCL9 ARAP1 AMN ANK1 COPG1 TMEM104C3orf67 BEND5 ARF5 ANAPC10 ANKRD28 CREB3 SEC16ACALML4 C3orf67 ARF6 ANKFY1 AOC3 CREB3L4 ANGPTL2CCL2 CD36 ARSE ANKRD49 AP1AR CTSZ GPR107CCNI CFTR ARV1 ANXA13 AP1B1 CXCL8 FAM8A1CEP85 CHRM4 ATL1 AOC3 AP1G2 F2R GCC2CLINT1 CHST9 ATP1A1 AP1AR AP1M2 FADD SLC35A2CLU CLEC14A ATP1A3 AP3B1 AP1S1 FEZ1 YIF1ACNGB1 CNGA4 ATP2B3 AP4S1 AP1S3 GALNT15 GORASP2CNTNAP2 CNTFR ATP8B1 APBA1 AP3M1 GJB2 STX5COG2 CPQ ATXN2 APBA2 AP4E1 GOSR2 COPACOL1A1 CSPG5 B2M APH1A AP5B1 GRAMD3 WIPI1COPE CYTH3 B3GALNT1 APOB APOH HLA-DPA1 GAKCOQ10A DCSTAMP B3GALT2 APOO APOM HLA-DRA CHST11CRHR1 DCTN3 B3GAT3 ARCN1 APOO HSPA5 GOLGA2CTGF EPHA3 B3GNT2 ARF3 ARCN1 IFT74 SLC30A7CTSC F2R B3GNT8 ARF4 AREG IGFBP1 ZNF622CTSZ FAM21A B3GNT9 ARF5 ARFGAP1 IGFBP6 GCC1CXCL8 FAM229B B4GALNT2 ARFGAP1 ARFGAP3 LIG1 ARL1CYB5R2 FAM8A1 B4GALNT4 ARFGAP3 ARFIP1 MGAT2 AFTPHDBNL FBXL14 B4GALT1 ARFGEF1 ARHGAP4 MKRN2OS RIN2DEFB4A FBXW7 B4GALT5 ARFGEF2 ARHGEF2 MUC20 SART1DIAPH2 FEM1A BCL6 ARFIP1 ARHGEF7 NCKAP5 WDR45BDMKN FMNL2 BIRC7 ARL3 ARL1 NCSTN ACBD3DOCK4 FTH1 BLZF1 ASCC3 ARMCX3 PGAP3 ZNF526DOPEY2 GABARAPL1BST2 ASIC4 ARPC2 PIFO SLC30A5DPH5 GGA2 BTN3A3 ATAT1 ARSA PPP1R15A TMF1DSEL GLT8D2 C11orf24 ATG9A ARSB R3HDM2 ARFGAP1DUSP10 GOLGA6C C14orf80 ATP2A1 ARSI SEC23B GBF1ERI2 GOLGA8G C1GALT1C1ATP6V1A ASCC3 SEC31B ERICH5F2R GOLGA8M C4orf32 ATP8B1 ASH1L SEPP1 PPIL6FAM198B GZF1 C5orf15 ATP8B3 ASIC1 SLC33A1 RINT1FEZ1 HACE1 C7orf49 B3GALT5 ASTN1 SPEF2 GOLGA1

Page 722 of 781Diabetes

FIBIN HEPACAM2CACNA1A B3GAT1 ATAT1 SPIRE1 IMPAD1FKBP9 HHAT CACNB3 B3GNT3 ATF6B STC2 NEO1FOLR1 HLA-DRA CALML4 B3GNT4 ATL3 STX6 TBC1D23FRMD3 HLA-G CAMKMT B4GALT2 ATOX1 TPTE2 PLEKHA3FUT1 HPD CAPN2 B4GALT5 ATP2C2 VCP YIPF5GALNT12 HS6ST1 CASP10 B4GALT7 ATP6V1A VPS52 LIG1GALNT4 IER3IP1 CAT BCAN ATP8A1 VTI1A OSBPGAS1 ING2 CCDC110 BCAP29 ATP8A2 WDR88 RER1GNRH1 JPH4 CCDC68 BET1 ATP9B ZCCHC4 COPG1GOLGA6L9KCNA5 CCDC71L BGN ATR ZNF526 SYAP1GOLGA8G KIAA1324 CCL2 BIRC7 ATXN2 SDE2GPC3 LAMP1 CCNI2 BMP1 AXIN2 MED8GRAMD3 LAMP5 CD36 BRSK2 B3GALT5 GOLGB1HCK LAMTOR1 CD46 BST2 B3GAT1 ABCC8HHAT LARP7 CD47 C11orf73 B3GAT3 B4GALNT3HKR1 LRRC42 CD68 C17orf75 B3GNT2 DYMHLA-DQB1 MGAT4C CD74 C19orf80 B3GNT3 SMAP1HLA-DRA MUC12 CD99L2 C1GALT1C1B3GNT7 PRICKLE2HLA-DRB5 MVB12B CEL C1QA B4GALT1 GCKHPD NCAM1 CERS1 C2orf54 B4GALT4 GLT8D2ID1 NDFIP1 CFTR CABP1 B4GALT5 TVP23C-CDRT4IFT74 NGFR CHD7 CABP2 B4GALT7 FUT8IL15RA NSG1 CHID1 CACNB3 BACE2 MYRIPIPO5 NTN3 CHPF CALU BBS1 MESTISLR NYNRIN CHST14 CAND1 BEGAIN COG5KDELC1 OAZ2 CHST2 CASP10 BICD2 ZC3HAV1KIAA0319L OCRL CHST8 CASQ1 BLOC1S1 YIPF2KLHL12 PCDHGC4 CHST9 CAT BLOC1S3 COG3LACTB2 PCED1B CIB1 CAV3 BLZF1 RXRALDLR PHF7 CLEC2D CCDC186 BOK RAB6ALIPG PI4K2A CLIC5 CCDC91 BROX TSPAN9LMTK3 PRKAR2B CLIP3 CCPG1 C11orf73 GOLPH3LMX1A PRKCD CLSTN1 CD46 C12orf43 NIPA2LRRC27 PRMT5 CLSTN2 CD74 C1QA PAQR8LYN PROC CLTA CD79B C1QTNF3 YIPF4MAN1A1 PROS1 CMTM4 CDC123 C20orf96 GOLIM4MARCO PRTFDC1 CNIH3 CDC25A C2orf80 PRKCDMICB PSAP CNTFR CDH15 C3orf58 COPB1MIF4GD PSEN2 COG4 CDK5RAP2 C3orf67 SLC18B1MPL RAB12 COL8A2 CHP1 C4orf32 DNAJC5MPLKIP RAB1A COPG2 CHPF C7orf49 KLF7MYO1B RASGRF1 COPZ2 CHPT1 CALN1 HSPB6NAB1 RGPD3 COQ10A CHST5 CALU SLC30A6NCAM1 RGPD4 CORO6 CLCC1 CAMKMT ZCCHC4NCKAP5 RGPD8 CREB3L4 CLCN3 CAND1 CCDC186NCSTN RHBDD2 CRYAB CLIC5 CANT1 PLCXD3NDST1 RHOBTB3 CRYZ CLINT1 CAPN2 USP8NGF RHOQ CSF2RB CLSPN CAPN8 GCNT4NMT2 RIMBP2 CTGF CLTC CAT VAMP4NOD2 RRAGB CTSC CLTCL1 CAV2 QPCTL

Page 723 of 781 Diabetes

NSUN6 SCAMP5 CXCL16 CNGB1 CBFA2T3 ZNF527NTAN1 SCPEP1 CYBRD1 CNIH1 CBLN3 ZNF75DNXN SDE2 CYP2U1 CNTNAP2 CCDC25 B2MOGFRL1 SEC14L5 CYTH3 COG2 CCDC64 ZMYND19OSBP SGCE DCBLD2 COG5 CCDC68 ILVBLPCDH18 SH3GL2 DCLRE1C COL16A1 CCDC93 ARFIP2PDE9A SIX5 DCTN2 COL7A1 CCL2 ARIH1PDGFRL SLC1A5 DEFB4A COPA CCNB2 PPP1R15BPGAP3 SPCS1 DEFB4B COPB2 CD59 CD59PLA2G12A STMN2 DENND5A COPE CD74 HGDPLCG1 SVIP DHRS11 COPZ1 CDC123 SCG2PLD2 SYNDIG1L DHX58 CORO7 CDC25A CCPG1PLPP3 SYT15 DNAJC5 CPE CDC42 TSNAXPLSCR1 TATDN3 DPH5 CPTP CDC42EP1 GOLGA4POLR1D TBC1D20 DPP7 CREB3L2 CDC6 LAPTM4APOLR3GL TIPIN DPY30 CRHR2 CDIPT PTPRFPOMT1 TMC6 DSE CRYZ CDK13 CCDC146PPP2R5C TMEM130 DUSP10 CSGALNACT2CHEK2 ASCC3PRELP TMEM184BDUSP26 CSNK1A1 CHID1 CNKSR2PRKAA2 TMEM251 DYNLT1 CSNK2B CHMP2A GORABPROS1 TMEM59 EFHD1 CSPG4 CHP1 CASC4PSMG1 TPST1 ELF3 CST3 CHPT1 IGFBP5RAB20 TRAPPC10 EMID1 CTLA4 CHSY1 TLR5RARRES1 VAMP4 ENPP7 CTSC CIB1 CHST2RHOQ VMA21 EPHA4 CTSZ CLCC1 ANKRD40RNF24 WWOX ERP44 CUL3 CLTA USO1RNPEP XPA EVPL CUL5 CLTC PDXDC1RUNX3 ZADH2 EXOC6 CYTH3 CLTCL1 FURINSEC24A ZC3H12B F2RL1 DAB1 CLVS1 YIF1BSEPP1 ZDHHC24 F7 DCC CMTM4 TRIP11SERTAD1 ZKSCAN2 F8 DCLRE1C CNIH1 NBASSGMS1 ZNF280D FAM109A DCSTAMP CNIH4 FKBP14SLC11A2 ZNF461 FAM198B DCTN3 CNST AMIGO2SLC39A14 ZNF629 FAM219B DDHD2 COG4 SLC6A9SLMAP ZP3 FAM228B DEFA4 COL7A1 ARMCX3SMYD3 FAM78B DEFA6 COMMD1 DOCK4SNX17 FEZ1 DENND5A COPB1 RASSF6SNX5 FGD1 DHX58 COPE ARCN1SPEF2 FGFR3 DIAPH2 CORO6 SACM1LSPRY4 FGFR4 DLG1 CPQ FKBP9ST3GAL1 FIBIN DLK1 CREB3 MBOAT4ST3GAL4 FLNA DNAJC6 CREB3L4 TRAPPC12ST8SIA2 FMNL2 DNM1L CSGALNACT1 ZBTB5STC2 FRMD3 DSE CSNK1A1 TSHZ2STX11 FRMD4A EAPP CTNNA1 CEP83STX3 FSTL3 EBAG9 CTNND2 LRRC4TAF11 FTH1 EEF2 CUBN PDE4BTANGO2 FUT1 EFCAB14 CUL3 FEM1ATAPBP FUT5 ENPP2 CUL7 BLOC1S3TCP11L1 FZD5 EPB41 CWF19L1 PWP1

Page 724 of 781Diabetes

TIAL1 GABARAPL1EPHA4 CXCL14 EAPPTMED1 GABRD EPS15 CXCL8 FAM114A1TMEM132A GALK1 ERC1 CYB5R2 VPS54TMEM133 GALNT11 ERGIC2 CYP2D6 ISLRTMEM165 GALNT16 ERGIC3 CYP2E1 GLB1TMEM25 GAS6 ERP44 CYP2U1 STX6TMEM43 GBP1 EVI5 DBI MBNL3TNFAIP2 GBP2 EVPL DCBLD2 ARFGEF2TOM1L1 GBP3 EXOC1 DCTN1 NUDT7TRAF3IP2 GBP4 EXOC2 DDX54 OSBPL9TRAPPC2 GBP5 F7 DENND2A ARFGAP3USF1 GCNT3 FAM20B DENND4C CACNB3VCP GDI2 FAM3C DHCR24 SREBF1VPS35 GJB2 FAM8A1 DHRS12 SLC6A16WASL GKAP1 FAR2 DIAPH2 LRRC27WLS GLT8D1 FBXL14 DNAJC5 KIAA1211ZC3H12C GLT8D2 FCGBP DNM2 RNF121ZMPSTE24 GNAS FES DPP7 FAM20CZNF25 GOLGA8S FNDC3A DPY30 TMEM53ZNF527 GPC1 FRMD4A DTX3 ERGIC2ZNF564 GRB14 FURIN DYM VGF

HCK FUT3 DYNLT1 SLC35C1HDAC5 FUT6 E2F3 PDGFRBHELLS FUT7 EDN1 COL18A1HEPACAM2FZD5 EGFR WDTC1HLA-A GABARAPL2EI24 CXXC4HLA-B GAD2 ELF3 NAB1HLA-C GAK EMP2 TMEM214HLA-DPA1 GAL3ST4 ENTHD2 TSPAN3HLA-DPB1 GALNT12 EPB41 AKAP9HLA-DQA1 GCC2 ERI2 BCL6HLA-DQA2 GCG ERP44 FLNBHLA-DQB1 GDI2 EXOC1 F5HLA-DQB2 GGA3 EXOC5 B4GALT3HLA-DRA GLCE EXOC6 MVB12BHLA-DRB1 GLT8D1 EXOC7 PPT1HLA-F GNAI3 EXT1 MFAP3HLA-G GNAS F10 CCDC69HPS3 GOLGA4 F2 TGFB1HS3ST1 GOLGA5 F2RL1 SIPA1L3HS3ST3B1 GOLGA7 F7 TM9SF3HS6ST1 GOLIM4 FADD TOM1L2HYAL2 GOLPH3 FAM107B MPZL3IFNGR2 GORASP2 FAM114A1 SMIM13IFT20 GRAMD3 FAM207A ZNF532IL15 GRIA1 FAM20A FAM199XIL15RA GSAP FAM20B ZMYM5IL17RD HAUS2 FBXL14 RAB20IL18 HHAT FBXO31 GOPCING2 HPD FBXW7 SPP1

Page 725 of 781 Diabetes

ISLR HS2ST1 FCGBP ADAT2JAG1 HSPA12A FEM1A TIMP1JAKMIP3 HSPD1 FEZ2 YIPF3JPH4 HSPG2 FGD1 LYZKCNA5 HTT FGD2 IGFBP7KDELC1 ICA1 FGD6 BGNKDELR1 ID1 FGFR2 ARFGEF1KIAA1324 IMPAD1 FLNA LY75KIFC3 INS FLNB ARHGEF10LKRT18 IPO5 FPR1 FMNL3LACTB2 ITIH2 FRMD4A VPS51LAMP5 ITM2B FRMD5 SLC23A2LAMTOR1 KDELR2 FSTL3 RASGRF1LAP3 KIFAP3 FTH1 PLPP3LDLR KRT2 FTL TJAP1LDLRAD1 LAPTM4A FUT10 DHRS11LFNG LARP7 FUT11 SMIM5LGR5 LAX1 FUT2 SORT1LIFR LCK FUT3 ARSELIMK2 LGR5 FUT4 GCGRLIPG LMAN1 FUT6 FAM3CLITAF LMAN1L GAGE1 FAM78BLMAN2L LRBA GAL3ST2 EXOC3L2LYN LYL1 GAL3ST4 ARFIP1MAML2 LYPLA1 GALK2 MGAT2MAN1A2 MAMLD1 GALNT1 STX12MANSC1 MAN1A1 GALNT14 FCGR2AMAP4K2 MAN1A2 GALNT16 SCPEP1MATN3 MAN2A1 GALT ATRMDGA1 MANF GAS8 TVP23BMEST MAP2K1 GBA2 CALHM5MFNG MAP2K7 GCC1 RFC2MGAT2 MAP4K2 GCGR ZNF569MGAT5B MAPK1 GCNT3 DLC1MICB MAPK3 GDF15 CWF19L1MIF4GD MAPK8IP3 GGA3 CALML4MLST8 MAPKAP1 GJA1 PCDH18MMP11 MAPRE1 GJB2 SNAPINMUC15 MARCO GKAP1 CD36MUC20 MASP2 GLIPR2 GALNT14MUC4 MBD1 GLIS3 UBXN6MVB12B MBTPS1 GLYATL1 TANGO6MYO1B MEST GLYCTK EI24NAPA MFAP3 GNAI3 DAPK2NAPG MFNG GNB1 EFCAB14NBN MGAT2 GNB3 ASIC1NCOA7 MGAT3 GNPDA1 ST8SIA4NDFIP2 MIA3 GNPNAT1 COG2NDST3 MICB GNRH1 CYTH2NECAB3 MMP11 GOLGA7 GIPC3

Page 726 of 781Diabetes

NKD2 MMP24 GOLGA7B GLG1NMT2 MON2 GOLGA8N SLC35C2NOD2 MSH6 GOLIM4 TMEM87ANOVA2 MTOR GOLT1A TVP23CNRGN MTUS1 GOLT1B ZMYND8NRTN MUC6 GOSR1 GTPBP1NSG1 MUC7 GOSR2 ASB7NTAN1 MVB12B GPC1 SPRY1NUCB1 NAA60 GPC5 BEGAINOGFRL1 NBEA GPR143 LRIG2OPALIN NBN GRB2 NCKAP5OPTN NCOA4 GRIA1 FAM210AP2RX3 NDFIP1 GSAP ST6GALNAC4P4HB NDST4 GSKIP METTL26PARP10 NFE2L2 GTF2E1 RPRD1APCED1B NGFR GTPBP4 CPEB4PCSK9 NIPA2 H1F0 MDGA1PDGFC NOD2 HEPACAM2 DDX31PDGFD NOS3 HERC1 BHLHA15PDIA6 NRGN HKR1 RPGRPGAP2 NUCB2 HLA-A SH3BP5LPHF7 OCRL HLA-DPA1 TTC33PITPNB OMD HLA-DPB1 SPNS1PKDCC OSBP HMGB1 ADCY6PKMYT1 OSBPL10 HMOX1 SYNGR4PLCE1 OSBPL11 HOXB6 INPPL1PLCXD3 OSBPL9 HRAS SMPDL3BPLD2 PACS1 HS3ST1 SCOCPLSCR1 PAM HS3ST2 FEZ2PODXL2 PANK3 HS3ST3A1 MDFICPOMT1 PAQR3 HS6ST2 CCNIPPP1R1C PARK2 HSPA12A GBP4PRKD2 PAX2 HSPB8 PCED1BPROC PCSK6 ID1 PI4KBPROM1 PDCD10 IFT20 ZNF576PRRG4 PDE9A IGFBP6 MAP2K7PRTFDC1 PDGFB IGFBP7 WWC1PRX PDGFRL IL13RA1 NXNPSMD11 PDIA6 IL15RA CD99PTP4A2 PEX5 IMPAD1 MSH6RAB19 PIK3C2A INMT TP53I11RAB20 PIKFYVE INPP5E APBA1RAB2B PJA2 INSIG2 ITIH5RAB33A PLA2G5 ITGA5 TRRAPRAB37 PLAGL1 JAG1 SELENOPRANGRF PLCB3 KBTBD8 DHRS12RAP1GAP PLCG1 KDELC1 KIAA1755RARRES1 PLD1 KDELR2 C3orf67RASGEF1A PLD2 KIAA0141 PSMD6RASGRF1 PLK3 KIAA0319L MPPE1

Page 727 of 781 Diabetes

RASIP1 PMEPA1 KIAA1324 MAN1A1RASSF9 PMF1 KIAA2013 STX8RBM20 PNRC2 KIF1C MGAT4ARCBTB2 POLQ KIF3B AP1ARRND3 POLR1D KIFC3 CCDC68RNF157 PPIL6 KLC1 GALNT10RNF182 PPP2R3C KLF5 MARF1RNF214 PPP2R5C KLHL12 HMOX1RNF24 PPP6R1 KRBOX1 SMAD6RNPEP PPT1 KRT18 ARL15RP2 PRDM2 LACTB2 AP3B1RSAD2 PREB LAMTOR1 ANAPC10RTN3 PREPL LAP3 SULT1B1RUNX3 PRKAR2A LARGE ZDHHC9SCFD1 PRKG1 LARP7 RIOK3SCOC PRMT5 LASP1 FUT11SCYL3 PROZ LCK HDAC3SDC1 PRX LDLR PDGFDSDC2 PSENEN LHFPL4 PCOLCESEC11A PSMB3 LIG1 TMEM196SEC11C PSMD11 LIMK1 BROXSEC14L5 PSMD6 LMAN1 NPTX2SECTM1 PSMG1 LMAN2 EXT2SEPP1 RAB14 LRIG2 CCNI2SERTAD1 RAB1A LRRK2 CTNND2SGMS1 RAB21 LST1 RBP5SH3D19 RAB2A LUM HLA-ASLA2 RAB30 LYN B3GNT9SLC11A2 RAB6B LYPLA1 BIRC6SLC18B1 RABAC1 LZTR1 ST8SIA3SLC23A2 RAF1 MALL PARP10SLC29A3 RAPSN MAN2A1 RCBTB2SLC30A5 RARRES1 MAP2K1 ZNF496SLC30A7 RCBTB2 MAPK1 ABCC4SLC35B2 RHEB MAPK8IP3 NNMTSLC35D1 RHOBTB3 MAPKAP1 EMC9SLC39A14 RIOK3 MAPRE1 POSTNSLC9A8 RNF122 MARCH11 CDC25ASLITRK5 RNF13 MDFIC ARSASNCB RNF139 METTL15 WSCD1SNCG ROCK1 MFAP3 NCOA7SNX2 RPH3A MGAT2 SIGLEC15SNX5 RRAGA MGAT5 C1QTNF3SNX6 RTN3 MICAL2 RIPOR1SORL1 RUNX3 MMD SEC11CSORT1 SACM1L MMD2 TM9SF1SOX7 SAR1A MMEL1 GGA1SPATA16 SAR1B MMGT1 ENTPD6SPPL2A SCAMP1 MMP14 ZNF287SRGN SCAMP3 MOB4 ZADH2

Page 728 of 781Diabetes

ST3GAL2 SCAMP4 MON2 NETO2ST3GAL5 SCFD1 MPHOSPH9 GALNT2ST6GAL2 SCPEP1 MPZL3 ESDST6GALNAC6SDC2 MSH6 ZNRF3ST8SIA3 SEC11A MUC1 NUCB2STEAP4 SEC13 MUC12 HID1STK16 SEC14L1 MUC13 QSOX2STS SEC14L4 MUC20 NUDT18STX10 SEC22B MYO1B RGL1STX11 SEC23B MYO5A FAM174ASULT1B1 SEC23IP MYO6 ZFAND4SURF4 SEC24B NAB1 SLC36A4SYNGR4 SEC24D NAPG GALNT3SYT17 SECTM1 NAPRT GNB3TAPBP SERPINB10NCAM1 HDAC5TAPBPL SGCE NCAN GFRA1THEMIS2 SGMS1 NCKAP5 NIPAL1TLR3 SH3GL2 NCOA4 CLEC14ATLR8 SH3GLB1 NCSTN OTUD1TMC8 SIPA1 NDFIP2 USP53TMED3 SIX5 NDST4 PODXL2TMEM130 SLC11A2 NEDD9 RFX2TMEM165 SLC1A6 NEO1 RBM20TMEM241 SLC30A1 NFE2L2 MAPK4TMEM25 SLC35A1 NFKBIE TMEM74BTMEM80 SLC35A3 NIPA2 PSMG1TNFAIP2 SLC35A5 NPC1 PLSCR1TPD52 SLC35E1 NPC1L1 COPETPST2 SLC35G2 NRAS KDELR1TRAF3IP2 SLC39A14 NRTN ALBTRAPPC2L SLC39A7 NSUN6 WDR44TRAPPC6A SLC9A7 OBSL1 GCNT3TRIM21 SLC9A8 OCRL GNPDA1TRIM55 SLPI OGFRL1 ATP7BTRIM69 SMAP1 OGN AMFRTSC22D3 SMO OPTN VWA5B2TYMP SNCB OSBP ARL2UBE2O SNX17 PAM MICAL2UGGT1 SNX2 PAQR3 RASSF2UGGT2 SOD3 PARP10 CCNJUGT3A2 SPAG9 PCDH10 DNMBPUNC45A SPCS1 PCNT DNM3USE1 SPG21 PDCD10 FAM207AUSF1 SPTBN5 PGAP2 GPR108VAMP5 SRCAP PGAP3 NOVA2VPS13C ST3GAL4 PHF7 TAF11VPS26B ST3GAL6 PI4K2A NYNRINVTI1B ST8SIA2 PICALM IFNGR2WDR41 ST8SIA5 PIDD1 ZNF461WHAMM STAM PIEZO1 VTI1B

Page 729 of 781 Diabetes

WLS STMN2 PIGQ ACCSWNT5A STX16 PITPNB SLC35A5WNT5B STX18 PITPNM1 SEC14L5WNT7A STX3 PJA2 CSF2RBWSCD1 SULT1B1 PKDCC ZNF326ZADH2 SYBU PLA2G4A PEX5ZC3H12B SYDE1 PLCG1 AOC3ZC3HAV1 SYTL2 PLEKHA3 MASP2ZDHHC1 TAF7 PLEKHM2 HABP4ZDHHC13 TAS2R16 POFUT2 HYIZMYND19 TCP11L1 POLL S1PR2ZNF148 TEX261 POLR1D FBXL8

TG POMT1 KCTD15TGFB1 PPIL2 CAND1TJAP1 PPIL6 ARL4DTMC6 PPP1R15A LHFPL4TMED1 PPP1R15B SYTL2TMED10 PPP2R5C GDF15TMED2 PPP6R1 CYP2U1TMED3 PRICKLE2 TMEM147TMED5 PRKAR2A NTAN1TMEM104 PRKCD HOXB6TMEM165 PRKG1 ENPP2TMEM180 PRMT5 LDLRAD1TMEM251 PROC TMEM176BTMEM30A PROM1 KCNF1TMEM59 PSENEN MVB12ATMEM59L PSMB3 CCL2TNFSF9 PSMB6 CYBRD1TNKS PSMD11 ZC3H12CTNNT1 PSMD6 COLEC12TOM1L1 PSMG1 CTSLTOPBP1 PTBP3 NCKAP5LTP53I11 PTCH1 C4orf33TP63 PTGDS ZBED9TP73 PTHLH COL16A1TPD52 PTP4A2 HELLSTRAPPC9 PWP1 ZNF18TSNAX QSOX2 ARSITSPYL5 R3HDM2 TGOLN2TTC33 RAB10 LATTTR RAB11A ARHGAP32TVP23B RAB11FIP1 CD74TXNDC15 RAB11FIP5 GBA2TYR RAB14 PSMD11UBXN2B RAB1A FAM20BUNC50 RAB21 PDE8AUNC93B1 RAB26 SYNGR2USO1 RAB27B CPQVAMP3 RAB29 LYN

Page 730 of 781Diabetes

VAMP5 RAB30 PDE4DIPVAMP7 RAB31 SPATA6VPS13C RAB32 ITM2BVPS26A RAB38 PROSER3VPS53 RAB7B PIP4K2AVPS54 RAB8A CDR1WDR44 RAB9A PTGS1WNT1 RABGAP1L SLC24A3WNT7B RANGRF HHATWWP1 RAPSN SRGNXPNPEP2 RASGEF1A NMT2YIF1A RASGRP3 COMPYIPF2 RFC2 CHI3L1YIPF6 RFNG SPCS1YWHAZ RFX2 SLC39A14ZBED5 RGS20 SAXO2ZC3H3 RHEB JAG1ZCWPW1 RHOF TMEM132EZDHHC4 RIC3 TSPAN31ZDHHC6 RIN2 RARRES1ZNF287 RITA1 JAM3ZNF576 RND3 MANSC1ZNF629 RNF121 CLEC2DZP2 RNF126 C17orf75

RNF139 ZMPSTE24RP2 RASGEF1ARPGR NADSYN1RPH3A NOD2RRAD TLR4RRAGA CGREF1RSAD2 RRAGARTN3 GDPD5RUSC1 C9orf64RUVBL1 TMEM80RXRA DPH5RYR1 GRAMD2BSCAMP2 LRRC8CSCAMP3 ZC3H12BSCOC TRAPPC3SCYL2 TBC1D5SDC4 TSLPSDE2 POF1BSEC13 FAM229BSEC16B TMEM123SEC23B CMTM4SEC23IP OAZ2SEC31B PSEN1SERINC3 TMEM41ASERPINB2 TRAF3IP2SERTAD1 CEP85

Page 731 of 781 Diabetes

SGMS2 PCSK5SGSM3 CASP10SH3GLB1 APPSIPA1L2 TMBIM4SLC1A5 ANO9SLC26A11SLC2A1SLC30A1SLC30A5SLC30A6SLC30A7SLC33A1SLC35A1SLC35A2SLC35A4SLC35B4SLC35C1SLC35E1SLC35G2SLC38A10SLC39A13SLC6A16SLC6A4SLC9A3R1SLC9A7SLMAPSMAP1SMIM13SNAP29SNX1SNX2SNX31SNX5SNX6SNX9SOD3SPATA16SPIRE1SPPL2ASPPL2BSPTBN1SRGNST3GAL1ST8SIA1STARD9STIP1STK11STMN4STSSTX16

Page 732 of 781Diabetes

STX3STX6STX8SUN3SVIPSYAP1SYNDIG1LSYNE1SYNGR4SYT17TAPBPTBC1D10CTBC1D5TCP11L1TCTN2TENM2TERF2TFGTGFATGFBITGOLN2THEMIS2TIAL1TIPARPTIPINTJAP1TLR5TLR8TM9SF1TMC8TMCO1TMED5TMEM104TMEM127TMEM130TMEM132ATMEM181TMEM214TMEM241TMEM41ATMEM43TMEM59LTMEM80TMEM87BTMF1TNRC6ATOM1L2TP73TRAPPC1TRAPPC2L

Page 733 of 781 Diabetes

TRIM69TRIP11TSC2TSR3TVP23ATXNDC15UBAC1UBAP1UBIAD1UGCGUHMK1USE1UXS1VAC14VAMP3VAMP4VAMP7VAMP8VCPVCPIP1VMA21VPS13AVPS26AVPS45VPS52VTI1AVTI1BWASLWDR41WHAMMWNT10BWNT7AXRN1YES1YIF1BYIPF5YIPF6YKT6YWHAZZBED9ZC3HAV1ZCCHC4ZDHHC12ZDHHC21ZDHHC3ZDHHC4ZDHHC8ZMPSTE24ZMYND8ZNF576

Page 734 of 781Diabetes

ZNF622ZP1ZW10

Page 735 of 781 Diabetes

T1D T2D BFAA4GALT A4GALT CYB5D1A4GNT A4GNT GOSR2ACSL4 ABCC8 SLC35E1ANGEL1 ACBD3 ZFPL1AP1B1 ACHE GOLGA3APOH ACPP MAFBARAP1 ACTR1A BSDC1ARF5 ADAM10 MAXARHGEF10LADAM19 BET1LB3GALNT2 ADCY3 PNPLA8B4GALNT4 ADCY6 ALKBH5BACE1 AGRN BLZF1BBS2 AGRP GOLGA5BCL6 AKAP9 LAPTM4BC1QTNF3 AKTIP COG6C20orf96 AMN TMEM104C3orf67 ANAPC10 SEC16ACALML4 ANKFY1 ANGPTL2CCL2 ANKRD49 GPR107CCNI ANXA13 FAM8A1CEP85 AOC3 GCC2CLINT1 AP1AR SLC35A2CLU AP3B1 YIF1ACNGB1 AP4S1 GORASP2CNTNAP2 APBA1 STX5COG2 APBA2 COPACOL1A1 APH1A WIPI1COPE APOB GAKCOQ10A APOO CHST11CRHR1 ARCN1 GOLGA2CTGF ARF3 SLC30A7CTSC ARF4 ZNF622CTSZ ARF5 GCC1CXCL8 ARFGAP1 ARL1CYB5R2 ARFGAP3 AFTPHDBNL ARFGEF1 RIN2DEFB4A ARFGEF2 SART1DIAPH2 ARFIP1 WDR45BDMKN ARL3 ACBD3DOCK4 ASCC3 ZNF526DOPEY2 ASIC4 SLC30A5DPH5 ATAT1 TMF1DSEL ATG9A ARFGAP1DUSP10 ATP2A1 GBF1ERI2 ATP6V1A ERICH5F2R ATP8B1 PPIL6FAM198B ATP8B3 RINT1FEZ1 B3GALT5 GOLGA1FIBIN B3GAT1 IMPAD1

Page 736 of 781Diabetes

FKBP9 B3GNT3 NEO1FOLR1 B3GNT4 TBC1D23FRMD3 B4GALT2 PLEKHA3FUT1 B4GALT5 YIPF5GALNT12 B4GALT7 LIG1GALNT4 BCAN OSBPGAS1 BCAP29 RER1GNRH1 BET1 COPG1GOLGA6L9BGN SYAP1GOLGA8G BIRC7 SDE2GPC3 BMP1 MED8GRAMD3 BRSK2 GOLGB1HCK BST2 ABCC8HHAT C11orf73 B4GALNT3HKR1 C17orf75 DYMHLA-DQB1 C19orf80 SMAP1HLA-DRA C1GALT1C1PRICKLE2HLA-DRB5 C1QA GCKHPD C2orf54 GLT8D2ID1 CABP1 TVP23C-CDRT4IFT74 CABP2 FUT8IL15RA CACNB3 MYRIPIPO5 CALU MESTISLR CAND1 COG5KDELC1 CASP10 ZC3HAV1KIAA0319L CASQ1 YIPF2KLHL12 CAT COG3LACTB2 CAV3 RXRALDLR CCDC186 RAB6ALIPG CCDC91 TSPAN9LMTK3 CCPG1 GOLPH3LMX1A CD46 NIPA2LRRC27 CD74 PAQR8LYN CD79B YIPF4MAN1A1 CDC123 GOLIM4MARCO CDC25A PRKCDMICB CDH15 COPB1MIF4GD CDK5RAP2 SLC18B1MPL CHP1 DNAJC5MPLKIP CHPF KLF7MYO1B CHPT1 HSPB6NAB1 CHST5 SLC30A6NCAM1 CLCC1 ZCCHC4NCKAP5 CLCN3 CCDC186NCSTN CLIC5 PLCXD3NDST1 CLINT1 USP8NGF CLSPN GCNT4NMT2 CLTC VAMP4NOD2 CLTCL1 QPCTLNSUN6 CNGB1 ZNF527

Page 737 of 781 Diabetes

NTAN1 CNIH1 ZNF75DNXN CNTNAP2 B2MOGFRL1 COG2 ZMYND19OSBP COG5 ILVBLPCDH18 COL16A1 ARFIP2PDE9A COL7A1 ARIH1PDGFRL COPA PPP1R15BPGAP3 COPB2 CD59PLA2G12A COPE HGDPLCG1 COPZ1 SCG2PLD2 CORO7 CCPG1PLPP3 CPE TSNAXPLSCR1 CPTP GOLGA4POLR1D CREB3L2 LAPTM4APOLR3GL CRHR2 PTPRFPOMT1 CRYZ CCDC146PPP2R5C CSGALNACT2ASCC3PRELP CSNK1A1 CNKSR2PRKAA2 CSNK2B GORABPROS1 CSPG4 CASC4PSMG1 CST3 IGFBP5RAB20 CTLA4 TLR5RARRES1 CTSC CHST2RHOQ CTSZ ANKRD40RNF24 CUL3 USO1RNPEP CUL5 PDXDC1RUNX3 CYTH3 FURINSEC24A DAB1 YIF1BSEPP1 DCC TRIP11SERTAD1 DCLRE1C NBASSGMS1 DCSTAMP FKBP14SLC11A2 DCTN3 AMIGO2SLC39A14 DDHD2 SLC6A9SLMAP DEFA4 ARMCX3SMYD3 DEFA6 DOCK4SNX17 DENND5A RASSF6SNX5 DHX58 ARCN1SPEF2 DIAPH2 SACM1LSPRY4 DLG1 FKBP9ST3GAL1 DLK1 MBOAT4ST3GAL4 DNAJC6 TRAPPC12ST8SIA2 DNM1L ZBTB5STC2 DSE TSHZ2STX11 EAPP CEP83STX3 EBAG9 LRRC4TAF11 EEF2 PDE4BTANGO2 EFCAB14 FEM1ATAPBP ENPP2 BLOC1S3TCP11L1 EPB41 PWP1TIAL1 EPHA4 EAPP

Page 738 of 781Diabetes

TMED1 EPS15 FAM114A1TMEM132AERC1 VPS54TMEM133 ERGIC2 ISLRTMEM165 ERGIC3 GLB1TMEM25 ERP44 STX6TMEM43 EVI5 MBNL3TNFAIP2 EVPL ARFGEF2TOM1L1 EXOC1 NUDT7TRAF3IP2 EXOC2 OSBPL9TRAPPC2 F7 ARFGAP3USF1 FAM20B CACNB3VCP FAM3C SREBF1VPS35 FAM8A1 SLC6A16WASL FAR2 LRRC27WLS FBXL14 KIAA1211ZC3H12C FCGBP RNF121ZMPSTE24 FES FAM20CZNF25 FNDC3A TMEM53ZNF527 FRMD4A ERGIC2ZNF564 FURIN VGFABCC8 FUT3 SLC35C1AGBL4 FUT6 PDGFRBAIG1 FUT7 COL18A1AKT3 FZD5 WDTC1APOB GABARAPL2CXXC4ARF5 GAD2 NAB1ARL15 GAK TMEM214ARL3 GAL3ST4 TSPAN3ARSI GALNT12 AKAP9ARV1 GCC2 BCL6ATP1A3 GCG FLNBATP8A1 GDI2 F5B3GALT4 GGA3 B4GALT3BACE1 GLCE MVB12BBAG5 GLT8D1 PPT1BCL9 GNAI3 MFAP3BEND5 GNAS CCDC69C3orf67 GOLGA4 TGFB1CD36 GOLGA5 SIPA1L3CFTR GOLGA7 TM9SF3CHRM4 GOLIM4 TOM1L2CHST9 GOLPH3 MPZL3CLEC14A GORASP2 SMIM13CNGA4 GRAMD3 ZNF532CNTFR GRIA1 FAM199XCPQ GSAP ZMYM5CSPG5 HAUS2 RAB20CYTH3 HHAT GOPCDCSTAMP HPD SPP1DCTN3 HS2ST1 ADAT2

Page 739 of 781 Diabetes

EPHA3 HSPA12A TIMP1F2R HSPD1 YIPF3FAM21A HSPG2 LYZFAM229B HTT IGFBP7FAM8A1 ICA1 BGNFBXL14 ID1 ARFGEF1FBXW7 IMPAD1 LY75FEM1A INS ARHGEF10LFMNL2 IPO5 FMNL3FTH1 ITIH2 VPS51GABARAPL1ITM2B SLC23A2GGA2 KDELR2 RASGRF1GLT8D2 KIFAP3 PLPP3GOLGA6C KRT2 TJAP1GOLGA8G LAPTM4A DHRS11GOLGA8M LARP7 SMIM5GZF1 LAX1 SORT1HACE1 LCK ARSEHEPACAM2LGR5 GCGRHHAT LMAN1 FAM3CHLA-DRA LMAN1L FAM78BHLA-G LRBA EXOC3L2HPD LYL1 ARFIP1HS6ST1 LYPLA1 MGAT2IER3IP1 MAMLD1 STX12ING2 MAN1A1 FCGR2AJPH4 MAN1A2 SCPEP1KCNA5 MAN2A1 ATRKIAA1324 MANF TVP23BLAMP1 MAP2K1 CALHM5LAMP5 MAP2K7 RFC2LAMTOR1 MAP4K2 ZNF569LARP7 MAPK1 DLC1LRRC42 MAPK3 CWF19L1MGAT4C MAPK8IP3 CALML4MUC12 MAPKAP1 PCDH18MVB12B MAPRE1 SNAPINNCAM1 MARCO CD36NDFIP1 MASP2 GALNT14NGFR MBD1 UBXN6NSG1 MBTPS1 TANGO6NTN3 MEST EI24NYNRIN MFAP3 DAPK2OAZ2 MFNG EFCAB14OCRL MGAT2 ASIC1PCDHGC4 MGAT3 ST8SIA4PCED1B MIA3 COG2PHF7 MICB CYTH2PI4K2A MMP11 GIPC3PRKAR2B MMP24 GLG1

Page 740 of 781Diabetes

PRKCD MON2 SLC35C2PRMT5 MSH6 TMEM87APROC MTOR TVP23CPROS1 MTUS1 ZMYND8PRTFDC1 MUC6 GTPBP1PSAP MUC7 ASB7PSEN2 MVB12B SPRY1RAB12 NAA60 BEGAINRAB1A NBEA LRIG2RASGRF1 NBN NCKAP5RGPD3 NCOA4 FAM210ARGPD4 NDFIP1 ST6GALNAC4RGPD8 NDST4 METTL26RHBDD2 NFE2L2 RPRD1ARHOBTB3 NGFR CPEB4RHOQ NIPA2 MDGA1RIMBP2 NOD2 DDX31RRAGB NOS3 BHLHA15SCAMP5 NRGN RPGRSCPEP1 NUCB2 SH3BP5LSDE2 OCRL TTC33SEC14L5 OMD SPNS1SGCE OSBP ADCY6SH3GL2 OSBPL10 SYNGR4SIX5 OSBPL11 INPPL1SLC1A5 OSBPL9 SMPDL3BSPCS1 PACS1 SCOCSTMN2 PAM FEZ2SVIP PANK3 MDFICSYNDIG1L PAQR3 CCNISYT15 PARK2 GBP4TATDN3 PAX2 PCED1BTBC1D20 PCSK6 PI4KBTIPIN PDCD10 ZNF576TMC6 PDE9A MAP2K7TMEM130 PDGFB WWC1TMEM184BPDGFRL NXNTMEM251 PDIA6 CD99TMEM59 PEX5 MSH6TPST1 PIK3C2A TP53I11TRAPPC10 PIKFYVE APBA1VAMP4 PJA2 ITIH5VMA21 PLA2G5 TRRAPWWOX PLAGL1 SELENOPXPA PLCB3 DHRS12ZADH2 PLCG1 KIAA1755ZC3H12B PLD1 C3orf67ZDHHC24 PLD2 PSMD6ZKSCAN2 PLK3 MPPE1ZNF280D PMEPA1 MAN1A1

Page 741 of 781 Diabetes

ZNF461 PMF1 STX8ZNF629 PNRC2 MGAT4AZP3 POLQ AP1ARA4GALT POLR1D CCDC68ABCC8 PPIL6 GALNT10ACAP3 PPP2R3C MARF1ACHE PPP2R5C HMOX1ACO1 PPP6R1 SMAD6ACPP PPT1 ARL15ACTR1B PRDM2 AP3B1AIG1 PREB ANAPC10AKR7A2 PREPL SULT1B1AMIGO2 PRKAR2A ZDHHC9ANXA13 PRKG1 RIOK3AP3B1 PRMT5 FUT11AP3S1 PROZ HDAC3AP5B1 PRX PDGFDAPBA1 PSENEN PCOLCEARAP1 PSMB3 TMEM196ARF5 PSMD11 BROXARF6 PSMD6 NPTX2ARSE PSMG1 EXT2ARV1 RAB14 CCNI2ATL1 RAB1A CTNND2ATP1A1 RAB21 RBP5ATP1A3 RAB2A HLA-AATP2B3 RAB30 B3GNT9ATP8B1 RAB6B BIRC6ATXN2 RABAC1 ST8SIA3B2M RAF1 PARP10B3GALNT1 RAPSN RCBTB2B3GALT2 RARRES1 ZNF496B3GAT3 RCBTB2 ABCC4B3GNT2 RHEB NNMTB3GNT8 RHOBTB3 EMC9B3GNT9 RIOK3 POSTNB4GALNT2 RNF122 CDC25AB4GALNT4 RNF13 ARSAB4GALT1 RNF139 WSCD1B4GALT5 ROCK1 NCOA7BCL6 RPH3A SIGLEC15BIRC7 RRAGA C1QTNF3BLZF1 RTN3 RIPOR1BST2 RUNX3 SEC11CBTN3A3 SACM1L TM9SF1C11orf24 SAR1A GGA1C14orf80 SAR1B ENTPD6C1GALT1C1SCAMP1 ZNF287C4orf32 SCAMP3 ZADH2C5orf15 SCAMP4 NETO2

Page 742 of 781Diabetes

C7orf49 SCFD1 GALNT2CACNA1A SCPEP1 ESDCACNB3 SDC2 ZNRF3CALML4 SEC11A NUCB2CAMKMT SEC13 HID1CAPN2 SEC14L1 QSOX2CASP10 SEC14L4 NUDT18CAT SEC22B RGL1CCDC110 SEC23B FAM174ACCDC68 SEC23IP ZFAND4CCDC71L SEC24B SLC36A4CCL2 SEC24D GALNT3CCNI2 SECTM1 GNB3CD36 SERPINB10HDAC5CD46 SGCE GFRA1CD47 SGMS1 NIPAL1CD68 SH3GL2 CLEC14ACD74 SH3GLB1 OTUD1CD99L2 SIPA1 USP53CEL SIX5 PODXL2CERS1 SLC11A2 RFX2CFTR SLC1A6 RBM20CHD7 SLC30A1 MAPK4CHID1 SLC35A1 TMEM74BCHPF SLC35A3 PSMG1CHST14 SLC35A5 PLSCR1CHST2 SLC35E1 COPECHST8 SLC35G2 KDELR1CHST9 SLC39A14 ALBCIB1 SLC39A7 WDR44CLEC2D SLC9A7 GCNT3CLIC5 SLC9A8 GNPDA1CLIP3 SLPI ATP7BCLSTN1 SMAP1 AMFRCLSTN2 SMO VWA5B2CLTA SNCB ARL2CMTM4 SNX17 MICAL2CNIH3 SNX2 RASSF2CNTFR SOD3 CCNJCOG4 SPAG9 DNMBPCOL8A2 SPCS1 DNM3COPG2 SPG21 FAM207ACOPZ2 SPTBN5 GPR108COQ10A SRCAP NOVA2CORO6 ST3GAL4 TAF11CREB3L4 ST3GAL6 NYNRINCRYAB ST8SIA2 IFNGR2CRYZ ST8SIA5 ZNF461CSF2RB STAM VTI1BCTGF STMN2 ACCS

Page 743 of 781 Diabetes

CTSC STX16 SLC35A5CXCL16 STX18 SEC14L5CYBRD1 STX3 CSF2RBCYP2U1 SULT1B1 ZNF326CYTH3 SYBU PEX5DCBLD2 SYDE1 AOC3DCLRE1C SYTL2 MASP2DCTN2 TAF7 HABP4DEFB4A TAS2R16 HYIDEFB4B TCP11L1 S1PR2DENND5A TEX261 FBXL8DHRS11 TG KCTD15DHX58 TGFB1 CAND1DNAJC5 TJAP1 ARL4DDPH5 TMC6 LHFPL4DPP7 TMED1 SYTL2DPY30 TMED10 GDF15DSE TMED2 CYP2U1DUSP10 TMED3 TMEM147DUSP26 TMED5 NTAN1DYNLT1 TMEM104 HOXB6EFHD1 TMEM165 ENPP2ELF3 TMEM180 LDLRAD1EMID1 TMEM251 TMEM176BENPP7 TMEM30A KCNF1EPHA4 TMEM59 MVB12AERP44 TMEM59L CCL2EVPL TNFSF9 CYBRD1EXOC6 TNKS ZC3H12CF2RL1 TNNT1 COLEC12F7 TOM1L1 CTSLF8 TOPBP1 NCKAP5LFAM109A TP53I11 C4orf33FAM198B TP63 ZBED9FAM219B TP73 COL16A1FAM228B TPD52 HELLSFAM78B TRAPPC9 ZNF18FEZ1 TSNAX ARSIFGD1 TSPYL5 TGOLN2FGFR3 TTC33 LATFGFR4 TTR ARHGAP32FIBIN TVP23B CD74FLNA TXNDC15 GBA2FMNL2 TYR PSMD11FRMD3 UBXN2B FAM20BFRMD4A UNC50 PDE8AFSTL3 UNC93B1 SYNGR2FTH1 USO1 CPQFUT1 VAMP3 LYNFUT5 VAMP5 PDE4DIP

Page 744 of 781Diabetes

FZD5 VAMP7 SPATA6GABARAPL1VPS13C ITM2BGABRD VPS26A PROSER3GALK1 VPS53 PIP4K2AGALNT11 VPS54 CDR1GALNT16 WDR44 PTGS1GAS6 WNT1 SLC24A3GBP1 WNT7B HHATGBP2 WWP1 SRGNGBP3 XPNPEP2 NMT2GBP4 YIF1A COMPGBP5 YIPF2 CHI3L1GCNT3 YIPF6 SPCS1GDI2 YWHAZ SLC39A14GJB2 ZBED5 SAXO2GKAP1 ZC3H3 JAG1GLT8D1 ZCWPW1 TMEM132EGLT8D2 ZDHHC4 TSPAN31GNAS ZDHHC6 RARRES1GOLGA8S ZNF287 JAM3GPC1 ZNF576 MANSC1GRB14 ZNF629 CLEC2DHCK ZP2 C17orf75HDAC5 AATF ZMPSTE24HELLS ABCA5 RASGEF1AHEPACAM2ABCA7 NADSYN1HLA-A ACAP3 NOD2HLA-B ACCS TLR4HLA-C ACSL4 CGREF1HLA-DPA1 ADAT1 RRAGAHLA-DPB1 ADAT2 GDPD5HLA-DQA1 AGPAT4 C9orf64HLA-DQA2 AGRN TMEM80HLA-DQB1 AGTRAP DPH5HLA-DQB2 AJUBA GRAMD2BHLA-DRA ALB LRRC8CHLA-DRB1 AMFR ZC3H12BHLA-F ANAPC10 TRAPPC3HLA-G ANK1 TBC1D5HPS3 ANKRD28 TSLPHS3ST1 AOC3 POF1BHS3ST3B1 AP1AR FAM229BHS6ST1 AP1B1 TMEM123HYAL2 AP1G2 CMTM4IFNGR2 AP1M2 OAZ2IFT20 AP1S1 PSEN1IL15 AP1S3 TMEM41AIL15RA AP3M1 TRAF3IP2IL17RD AP4E1 CEP85IL18 AP5B1 PCSK5

Page 745 of 781 Diabetes

ING2 APOH CASP10ISLR APOM APPJAG1 APOO TMBIM4JAKMIP3 ARCN1 ANO9JPH4 AREGKCNA5 ARFGAP1KDELC1 ARFGAP3KDELR1 ARFIP1KIAA1324 ARHGAP4KIFC3 ARHGEF2KRT18 ARHGEF7LACTB2 ARL1LAMP5 ARMCX3LAMTOR1 ARPC2LAP3 ARSALDLR ARSBLDLRAD1 ARSILFNG ASCC3LGR5 ASH1LLIFR ASIC1LIMK2 ASTN1LIPG ATAT1LITAF ATF6BLMAN2L ATL3LYN ATOX1MAML2 ATP2C2MAN1A2 ATP6V1AMANSC1 ATP8A1MAP4K2 ATP8A2MATN3 ATP9BMDGA1 ATRMEST ATXN2MFNG AXIN2MGAT2 B3GALT5MGAT5B B3GAT1MICB B3GAT3MIF4GD B3GNT2MLST8 B3GNT3MMP11 B3GNT7MUC15 B4GALT1MUC20 B4GALT4MUC4 B4GALT5MVB12B B4GALT7MYO1B BACE2NAPA BBS1NAPG BEGAINNBN BICD2NCOA7 BLOC1S1NDFIP2 BLOC1S3NDST3 BLZF1

Page 746 of 781Diabetes

NECAB3 BOKNKD2 BROXNMT2 C11orf73NOD2 C12orf43NOVA2 C1QANRGN C1QTNF3NRTN C20orf96NSG1 C2orf80NTAN1 C3orf58NUCB1 C3orf67OGFRL1 C4orf32OPALIN C7orf49OPTN CALN1P2RX3 CALUP4HB CAMKMTPARP10 CAND1PCED1B CANT1PCSK9 CAPN2PDGFC CAPN8PDGFD CATPDIA6 CAV2PGAP2 CBFA2T3PHF7 CBLN3PITPNB CCDC25PKDCC CCDC64PKMYT1 CCDC68PLCE1 CCDC93PLCXD3 CCL2PLD2 CCNB2PLSCR1 CD59PODXL2 CD74POMT1 CDC123PPP1R1C CDC25APRKD2 CDC42PROC CDC42EP1PROM1 CDC6PRRG4 CDIPTPRTFDC1 CDK13PRX CHEK2PSMD11 CHID1PTP4A2 CHMP2ARAB19 CHP1RAB20 CHPT1RAB2B CHSY1RAB33A CIB1RAB37 CLCC1RANGRF CLTARAP1GAP CLTCRARRES1 CLTCL1RASGEF1A CLVS1

Page 747 of 781 Diabetes

RASGRF1 CMTM4RASIP1 CNIH1RASSF9 CNIH4RBM20 CNSTRCBTB2 COG4RND3 COL7A1RNF157 COMMD1RNF182 COPB1RNF214 COPERNF24 CORO6RNPEP CPQRP2 CREB3RSAD2 CREB3L4RTN3 CSGALNACT1RUNX3 CSNK1A1SCFD1 CTNNA1SCOC CTNND2SCYL3 CUBNSDC1 CUL3SDC2 CUL7SEC11A CWF19L1SEC11C CXCL14SEC14L5 CXCL8SECTM1 CYB5R2SEPP1 CYP2D6SERTAD1 CYP2E1SGMS1 CYP2U1SH3D19 DBISLA2 DCBLD2SLC11A2 DCTN1SLC18B1 DDX54SLC23A2 DENND2ASLC29A3 DENND4CSLC30A5 DHCR24SLC30A7 DHRS12SLC35B2 DIAPH2SLC35D1 DNAJC5SLC39A14 DNM2SLC9A8 DPP7SLITRK5 DPY30SNCB DTX3SNCG DYMSNX2 DYNLT1SNX5 E2F3SNX6 EDN1SORL1 EGFRSORT1 EI24SOX7 ELF3SPATA16 EMP2SPPL2A ENTHD2

Page 748 of 781Diabetes

SRGN EPB41ST3GAL2 ERI2ST3GAL5 ERP44ST6GAL2 EXOC1ST6GALNAC6EXOC5ST8SIA3 EXOC6STEAP4 EXOC7STK16 EXT1STS F10STX10 F2STX11 F2RL1SULT1B1 F7SURF4 FADDSYNGR4 FAM107BSYT17 FAM114A1TAPBP FAM207ATAPBPL FAM20ATHEMIS2 FAM20BTLR3 FBXL14TLR8 FBXO31TMC8 FBXW7TMED3 FCGBPTMEM130 FEM1ATMEM165 FEZ2TMEM241 FGD1TMEM25 FGD2TMEM80 FGD6TNFAIP2 FGFR2TPD52 FLNATPST2 FLNBTRAF3IP2 FPR1TRAPPC2L FRMD4ATRAPPC6A FRMD5TRIM21 FSTL3TRIM55 FTH1TRIM69 FTLTSC22D3 FUT10TYMP FUT11UBE2O FUT2UGGT1 FUT3UGGT2 FUT4UGT3A2 FUT6UNC45A GAGE1USE1 GAL3ST2USF1 GAL3ST4VAMP5 GALK2VPS13C GALNT1VPS26B GALNT14VTI1B GALNT16WDR41 GALT

Page 749 of 781 Diabetes

WHAMM GAS8WLS GBA2WNT5A GCC1WNT5B GCGRWNT7A GCNT3WSCD1 GDF15ZADH2 GGA3ZC3H12B GJA1ZC3HAV1 GJB2ZDHHC1 GKAP1ZDHHC13 GLIPR2ZMYND19 GLIS3ZNF148 GLYATL1

GLYCTKGNAI3GNB1GNB3GNPDA1GNPNAT1GNRH1GOLGA7GOLGA7BGOLGA8NGOLIM4GOLT1AGOLT1BGOSR1GOSR2GPC1GPC5GPR143GRB2GRIA1GSAPGSKIPGTF2E1GTPBP4H1F0HEPACAM2HERC1HKR1HLA-AHLA-DPA1HLA-DPB1HMGB1HMOX1HOXB6HRASHS3ST1HS3ST2

Page 750 of 781Diabetes

HS3ST3A1HS6ST2HSPA12AHSPB8ID1IFT20IGFBP6IGFBP7IL13RA1IL15RAIMPAD1INMTINPP5EINSIG2ITGA5JAG1KBTBD8KDELC1KDELR2KIAA0141KIAA0319LKIAA1324KIAA2013KIF1CKIF3BKIFC3KLC1KLF5KLHL12KRBOX1KRT18LACTB2LAMTOR1LAP3LARGELARP7LASP1LCKLDLRLHFPL4LIG1LIMK1LMAN1LMAN2LRIG2LRRK2LST1LUMLYNLYPLA1

Page 751 of 781 Diabetes

LZTR1MALLMAN2A1MAP2K1MAPK1MAPK8IP3MAPKAP1MAPRE1MARCH11MDFICMETTL15MFAP3MGAT2MGAT5MICAL2MMDMMD2MMEL1MMGT1MMP14MOB4MON2MPHOSPH9MPZL3MSH6MUC1MUC12MUC13MUC20MYO1BMYO5AMYO6NAB1NAPGNAPRTNCAM1NCANNCKAP5NCOA4NCSTNNDFIP2NDST4NEDD9NEO1NFE2L2NFKBIENIPA2NPC1NPC1L1NRAS

Page 752 of 781Diabetes

NRTNNSUN6OBSL1OCRLOGFRL1OGNOPTNOSBPPAMPAQR3PARP10PCDH10PCNTPDCD10PGAP2PGAP3PHF7PI4K2APICALMPIDD1PIEZO1PIGQPITPNBPITPNM1PJA2PKDCCPLA2G4APLCG1PLEKHA3PLEKHM2POFUT2POLLPOLR1DPOMT1PPIL2PPIL6PPP1R15APPP1R15BPPP2R5CPPP6R1PRICKLE2PRKAR2APRKCDPRKG1PRMT5PROCPROM1PSENENPSMB3PSMB6

Page 753 of 781 Diabetes

PSMD11PSMD6PSMG1PTBP3PTCH1PTGDSPTHLHPTP4A2PWP1QSOX2R3HDM2RAB10RAB11ARAB11FIP1RAB11FIP5RAB14RAB1ARAB21RAB26RAB27BRAB29RAB30RAB31RAB32RAB38RAB7BRAB8ARAB9ARABGAP1LRANGRFRAPSNRASGEF1ARASGRP3RFC2RFNGRFX2RGS20RHEBRHOFRIC3RIN2RITA1RND3RNF121RNF126RNF139RP2RPGRRPH3ARRAD

Page 754 of 781Diabetes

RRAGARSAD2RTN3RUSC1RUVBL1RXRARYR1SCAMP2SCAMP3SCOCSCYL2SDC4SDE2SEC13SEC16BSEC23BSEC23IPSEC31BSERINC3SERPINB2SERTAD1SGMS2SGSM3SH3GLB1SIPA1L2SLC1A5SLC26A11SLC2A1SLC30A1SLC30A5SLC30A6SLC30A7SLC33A1SLC35A1SLC35A2SLC35A4SLC35B4SLC35C1SLC35E1SLC35G2SLC38A10SLC39A13SLC6A16SLC6A4SLC9A3R1SLC9A7SLMAPSMAP1SMIM13SNAP29

Page 755 of 781 Diabetes

SNX1SNX2SNX31SNX5SNX6SNX9SOD3SPATA16SPIRE1SPPL2ASPPL2BSPTBN1SRGNST3GAL1ST8SIA1STARD9STIP1STK11STMN4STSSTX16STX3STX6STX8SUN3SVIPSYAP1SYNDIG1LSYNE1SYNGR4SYT17TAPBPTBC1D10CTBC1D5TCP11L1TCTN2TENM2TERF2TFGTGFATGFBITGOLN2THEMIS2TIAL1TIPARPTIPINTJAP1TLR5TLR8TM9SF1

Page 756 of 781Diabetes

TMC8TMCO1TMED5TMEM104TMEM127TMEM130TMEM132ATMEM181TMEM214TMEM241TMEM41ATMEM43TMEM59LTMEM80TMEM87BTMF1TNRC6ATOM1L2TP73TRAPPC1TRAPPC2LTRIM69TRIP11TSC2TSR3TVP23ATXNDC15UBAC1UBAP1UBIAD1UGCGUHMK1USE1UXS1VAC14VAMP3VAMP4VAMP7VAMP8VCPVCPIP1VMA21VPS13AVPS26AVPS45VPS52VTI1AVTI1BWASLWDR41

Page 757 of 781 Diabetes

WHAMMWNT10BWNT7AXRN1YES1YIF1BYIPF5YIPF6YKT6YWHAZZBED9ZC3HAV1ZCCHC4ZDHHC12ZDHHC21ZDHHC3ZDHHC4ZDHHC8ZMPSTE24ZMYND8ZNF576ZNF622ZP1ZW10ACSL3ADI1AOC3AREGARFGAP3ARHGEF11ASCC3ATP8B3B4GALNT1BHLHE40C20orf196C20orf96C2orf76CDC6CNTNAP2COPG1CREB3CREB3L4CTSZCXCL8F2RFADDFEZ1GALNT15GJB2GOSR2

Page 758 of 781Diabetes

GRAMD3HLA-DPA1HLA-DRAHSPA5IFT74IGFBP1IGFBP6LIG1MGAT2MKRN2OSMUC20NCKAP5NCSTNPGAP3PIFOPPP1R15AR3HDM2SEC23BSEC31BSEPP1SLC33A1SPEF2SPIRE1STC2STX6TPTE2VCPVPS52VTI1AWDR88ZCCHC4ZNF526

Page 759 of 781 Diabetes

Names total GenesT1D_BFA 121 ARHGEF10L

ARSIDPH5MDGA1TRAF3IP2CCNIMAN1A1PCED1BNXNZMYND19WSCD1NCKAP5OAZ2FAM8A1DHRS11SLC39A14LYNSCPEP1SLC23A2MGAT2GLT8D2ISLRCYP2U1SEC14L5B3GNT9C1QTNF3SCOCCLEC14ACALML4COPECACNB3CASP10DNAJC5HDAC5RASGRF1SORT1PSMG1NOVA2CD36CCNI2CD74PLSCR1ST8SIA3PSMD11PARP10PODXL2HELLSPCDH18SEC11C

Page 760 of 781Diabetes

TAF11CMTM4NTAN1JAG1PRKCDZNF527OSBPCEP85AP3B1VAMP4NAB1COG2ZC3HAV1SLC30A5PLPP3SDE2PDGFDMESTCLEC2DRARRES1FAM78BRBM20HLA-AGCNT3FAM229BRAB20NYNRINFEM1AIFNGR2LDLRAD1B2MMANSC1BLZF1ARL15ARSEKDELR1SLC30A7ZMPSTE24LRRC27SYNGR4PLCXD3FKBP9NOD2VTI1BSRGNRASGEF1ANCOA7NMT2BCL6DOCK4

Page 761 of 781 Diabetes

ABCC8TMEM80CHST2CYBRD1ZC3H12CSULT1B1SPCS1CPQAMIGO2ZC3H12BCCL2GBP4SLC18B1CSF2RBRCBTB2HHATMVB12BC3orf67ZADH2CCDC68ZNF461APBA1

Page 762 of 781Diabetes

Names total GenesT2D-BFA 204 YIF1B

MDFICCTNND2GDF15TM9SF1ARL1ZNF576LAPTM4ASLC39A14STX8ASCC3ITM2BRXRACAND1PPP1R15BCYP2U1C1QTNF3SCOCACBD3ZCCHC4CACNB3TBC1D5CASP10DNAJC5MFAP3MSH6ADAT2RIN2GNPDA1GCC2COPATJAP1COPG1GOLPH3PSMD11TMEM104ATRZMYND8CCDC186IGFBP7JAG1SLC35A5PRKCDOSBPAP3B1TOM1L2DYMYIPF2VAMP4

Page 763 of 781 Diabetes

COG2ZC3HAV1ACCSC17orf75AOC3EFCAB14FURINPLEKHA3CWF19L1RRAGAHLA-AASIC1FEM1AIMPAD1ARFGEF2TMEM214TLR5GCGRBEGAINFLNBSLC30A7TSNAXBLOC1S3SYNGR4GOLGA5SRGNRASGEF1ALHFPL4ENPP2RIOK3TGFB1SLC6A16TMEM80ARSAPPT1SPCS1CPQNIPA2BGNBROXCCL2ANAPC10PRICKLE2HHATSMAP1MVB12BZNF287CCDC68TRIP11GBA2

Page 764 of 781Diabetes

ARMCX3QSOX2EI24ARSIFAM20BFAM3CHMOX1FAM207AMAN1A1RFC2NCKAP5CD59FAM8A1TVP23BLYNSCPEP1EAPPGCC1MGAT2AMFRNUCB2COPEDHRS12NEO1CCPG1MASP2PSMG1ZBED9ZNF526PSMD6SLC35A2CD74ARFIP1COG5SLC35E1AKAP9SACM1LMICAL2PARP10MAP2K7SYTL2FUT11TGOLN2MPZL3CMTM4HOXB6WDR44LIG1SLC30A6ADCY6

Page 765 of 781 Diabetes

GALNT14PWP1GOLIM4COL16A1TP53I11OSBPL9ARFGAP3YIF1ANAB1GOSR2SLC30A5SLC35C1VPS54PEX5COPB1TMEM41ASDE2RNF121MESTGORASP2ARFGEF1RARRES1GCNT3RPGRFAM114A1USO1BLZF1ZMPSTE24YIPF5GAKALBNOD2FEZ2VTI1BSTX6ARCN1ABCC8TTC33ERGIC2SULT1B1GOLGA4TMF1LRIG2ARFGAP1SMIM13RCBTB2PPIL6SYAP1AP1ARRFX2

Page 766 of 781Diabetes

C3orf67GNB3ZNF622CDC25AAPBA1

Page 767 of 781 Diabetes

Item OccurencesPresent InABCC8 3 T1D T2D BFAAP3B1 3 T1D T2D BFAAPBA1 3 T1D T2D BFAARSI 3 T1D T2D BFABLZF1 3 T1D T2D BFAC1QTNF3 3 T1D T2D BFAC3orf67 3 T1D T2D BFACACNB3 3 T1D T2D BFACASP10 3 T1D T2D BFACCDC68 3 T1D T2D BFACCL2 3 T1D T2D BFACD74 3 T1D T2D BFACMTM4 3 T1D T2D BFACOG2 3 T1D T2D BFACOPE 3 T1D T2D BFACPQ 3 T1D T2D BFACYP2U1 3 T1D T2D BFADNAJC5 3 T1D T2D BFAFAM8A1 3 T1D T2D BFAFEM1A 3 T1D T2D BFAGCNT3 3 T1D T2D BFAHHAT 3 T1D T2D BFAHLA-A 3 T1D T2D BFAJAG1 3 T1D T2D BFALYN 3 T1D T2D BFAMAN1A1 3 T1D T2D BFAMEST 3 T1D T2D BFAMGAT2 3 T1D T2D BFAMVB12B 3 T1D T2D BFANAB1 3 T1D T2D BFANCKAP5 3 T1D T2D BFANOD2 3 T1D T2D BFAOSBP 3 T1D T2D BFAPARP10 3 T1D T2D BFAPRKCD 3 T1D T2D BFAPSMD11 3 T1D T2D BFAPSMG1 3 T1D T2D BFARARRES1 3 T1D T2D BFARASGEF1A 3 T1D T2D BFARCBTB2 3 T1D T2D BFASCOC 3 T1D T2D BFASCPEP1 3 T1D T2D BFASDE2 3 T1D T2D BFASLC30A5 3 T1D T2D BFASLC30A7 3 T1D T2D BFASLC39A14 3 T1D T2D BFASPCS1 3 T1D T2D BFASRGN 3 T1D T2D BFASULT1B1 3 T1D T2D BFA

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SYNGR4 3 T1D T2D BFATMEM80 3 T1D T2D BFAVAMP4 3 T1D T2D BFAVTI1B 3 T1D T2D BFAZC3HAV1 3 T1D T2D BFAZMPSTE24 3 T1D T2D BFAA4GALT 2 T1D T2DA4GNT 2 T1D T2DACAP3 2 T1D T2DACBD3 2 T2D BFAACCS 2 T2D BFAACHE 2 T1D T2DACPP 2 T1D T2DACSL4 2 T1D T2DADAT2 2 T2D BFAADCY6 2 T2D BFAAKAP9 2 T2D BFAALB 2 T2D BFAAMFR 2 T2D BFAAMIGO2 2 T1D BFAANAPC10 2 T2D BFAANXA13 2 T1D T2DAOC3 2 T2D BFAAP1AR 2 T2D BFAAP1B1 2 T1D T2DAP5B1 2 T1D T2DAPOB 2 T1D T2DAPOH 2 T1D T2DARCN1 2 T2D BFAARF5 2 T1D T2DARFGAP1 2 T2D BFAARFGAP3 2 T2D BFAARFGEF1 2 T2D BFAARFGEF2 2 T2D BFAARFIP1 2 T2D BFAARHGEF10L 2 T1D BFAARL1 2 T2D BFAARL15 2 T1D BFAARL3 2 T1D T2DARMCX3 2 T2D BFAARSA 2 T2D BFAARSE 2 T1D BFAASCC3 2 T2D BFAASIC1 2 T2D BFAATP8A1 2 T1D T2DATP8B1 2 T1D T2DATR 2 T2D BFAATXN2 2 T1D T2DB2M 2 T1D BFAB3GAT3 2 T1D T2D

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B3GNT2 2 T1D T2DB3GNT9 2 T1D BFAB4GALT1 2 T1D T2DB4GALT5 2 T1D T2DBCL6 2 T1D BFABEGAIN 2 T2D BFABGN 2 T2D BFABIRC7 2 T1D T2DBLOC1S3 2 T2D BFABROX 2 T2D BFABST2 2 T1D T2DC17orf75 2 T2D BFAC1GALT1C1 2 T1D T2DC20orf96 2 T1D T2DC4orf32 2 T1D T2DC7orf49 2 T1D T2DCALML4 2 T1D BFACAMKMT 2 T1D T2DCAND1 2 T2D BFACAPN2 2 T1D T2DCAT 2 T1D T2DCCDC186 2 T2D BFACCNI 2 T1D BFACCNI2 2 T1D BFACCPG1 2 T2D BFACD36 2 T1D BFACD46 2 T1D T2DCD59 2 T2D BFACDC25A 2 T2D BFACEP85 2 T1D BFACHID1 2 T1D T2DCHPF 2 T1D T2DCHST2 2 T1D BFACIB1 2 T1D T2DCLEC14A 2 T1D BFACLEC2D 2 T1D BFACLIC5 2 T1D T2DCLINT1 2 T1D T2DCLTA 2 T1D T2DCNGB1 2 T1D T2DCNTNAP2 2 T1D T2DCOG4 2 T1D T2DCOG5 2 T2D BFACOL16A1 2 T2D BFACOPA 2 T2D BFACOPB1 2 T2D BFACOPG1 2 T2D BFACORO6 2 T1D T2DCREB3L4 2 T1D T2DCRYZ 2 T1D T2D

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CSF2RB 2 T1D BFACTNND2 2 T2D BFACTSC 2 T1D T2DCTSZ 2 T1D T2DCWF19L1 2 T2D BFACXCL8 2 T1D T2DCYB5R2 2 T1D T2DCYBRD1 2 T1D BFACYTH3 2 T1D T2DDCBLD2 2 T1D T2DDCLRE1C 2 T1D T2DDCSTAMP 2 T1D T2DDCTN3 2 T1D T2DDENND5A 2 T1D T2DDHRS11 2 T1D BFADHRS12 2 T2D BFADHX58 2 T1D T2DDIAPH2 2 T1D T2DDOCK4 2 T1D BFADPH5 2 T1D BFADPP7 2 T1D T2DDPY30 2 T1D T2DDSE 2 T1D T2DDYM 2 T2D BFADYNLT1 2 T1D T2DEAPP 2 T2D BFAEFCAB14 2 T2D BFAEI24 2 T2D BFAELF3 2 T1D T2DENPP2 2 T2D BFAEPHA4 2 T1D T2DERGIC2 2 T2D BFAERI2 2 T1D T2DERP44 2 T1D T2DEVPL 2 T1D T2DEXOC6 2 T1D T2DF2R 2 T1D T2DF2RL1 2 T1D T2DF7 2 T1D T2DFAM114A1 2 T2D BFAFAM207A 2 T2D BFAFAM20B 2 T2D BFAFAM229B 2 T1D BFAFAM3C 2 T2D BFAFAM78B 2 T1D BFAFBXL14 2 T1D T2DFBXW7 2 T1D T2DFEZ1 2 T1D T2DFEZ2 2 T2D BFAFGD1 2 T1D T2D

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FKBP9 2 T1D BFAFLNA 2 T1D T2DFLNB 2 T2D BFAFRMD4A 2 T1D T2DFSTL3 2 T1D T2DFTH1 2 T1D T2DFURIN 2 T2D BFAFUT11 2 T2D BFAFZD5 2 T1D T2DGAK 2 T2D BFAGALNT12 2 T1D T2DGALNT14 2 T2D BFAGALNT16 2 T1D T2DGBA2 2 T2D BFAGBP4 2 T1D BFAGCC1 2 T2D BFAGCC2 2 T2D BFAGCGR 2 T2D BFAGDF15 2 T2D BFAGDI2 2 T1D T2DGJB2 2 T1D T2DGKAP1 2 T1D T2DGLT8D1 2 T1D T2DGLT8D2 2 T1D BFAGNAS 2 T1D T2DGNB3 2 T2D BFAGNPDA1 2 T2D BFAGNRH1 2 T1D T2DGOLGA4 2 T2D BFAGOLGA5 2 T2D BFAGOLIM4 2 T2D BFAGOLPH3 2 T2D BFAGORASP2 2 T2D BFAGOSR2 2 T2D BFAGPC1 2 T1D T2DGRAMD3 2 T1D T2DHDAC5 2 T1D BFAHELLS 2 T1D BFAHEPACAM2 2 T1D T2DHKR1 2 T1D T2DHLA-DPA1 2 T1D T2DHLA-DPB1 2 T1D T2DHLA-DRA 2 T1D T2DHMOX1 2 T2D BFAHOXB6 2 T2D BFAHPD 2 T1D T2DHS3ST1 2 T1D T2DID1 2 T1D T2DIFNGR2 2 T1D BFAIFT20 2 T1D T2D

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IFT74 2 T1D T2DIGFBP7 2 T2D BFAIL15RA 2 T1D T2DIMPAD1 2 T2D BFAIPO5 2 T1D T2DISLR 2 T1D BFAITM2B 2 T2D BFAKDELC1 2 T1D T2DKDELR1 2 T1D BFAKIAA0319L 2 T1D T2DKIAA1324 2 T1D T2DKIFC3 2 T1D T2DKLHL12 2 T1D T2DKRT18 2 T1D T2DLACTB2 2 T1D T2DLAMTOR1 2 T1D T2DLAP3 2 T1D T2DLAPTM4A 2 T2D BFALARP7 2 T1D T2DLDLR 2 T1D T2DLDLRAD1 2 T1D BFALGR5 2 T1D T2DLHFPL4 2 T2D BFALIG1 2 T2D BFALRIG2 2 T2D BFALRRC27 2 T1D BFAMAN1A2 2 T1D T2DMANSC1 2 T1D BFAMAP2K7 2 T2D BFAMAP4K2 2 T1D T2DMARCO 2 T1D T2DMASP2 2 T2D BFAMDFIC 2 T2D BFAMDGA1 2 T1D BFAMFAP3 2 T2D BFAMFNG 2 T1D T2DMICAL2 2 T2D BFAMICB 2 T1D T2DMMP11 2 T1D T2DMPZL3 2 T2D BFAMSH6 2 T2D BFAMUC12 2 T1D T2DMUC20 2 T1D T2DMYO1B 2 T1D T2DNAPG 2 T1D T2DNBN 2 T1D T2DNCAM1 2 T1D T2DNCOA7 2 T1D BFANCSTN 2 T1D T2DNDFIP1 2 T1D T2D

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NDFIP2 2 T1D T2DNEO1 2 T2D BFANGFR 2 T1D T2DNIPA2 2 T2D BFANMT2 2 T1D BFANOVA2 2 T1D BFANRGN 2 T1D T2DNRTN 2 T1D T2DNSUN6 2 T1D T2DNTAN1 2 T1D BFANUCB2 2 T2D BFANXN 2 T1D BFANYNRIN 2 T1D BFAOAZ2 2 T1D BFAOCRL 2 T1D T2DOGFRL1 2 T1D T2DOPTN 2 T1D T2DOSBPL9 2 T2D BFAPCDH18 2 T1D BFAPCED1B 2 T1D BFAPDE9A 2 T1D T2DPDGFD 2 T1D BFAPDGFRL 2 T1D T2DPDIA6 2 T1D T2DPEX5 2 T2D BFAPGAP2 2 T1D T2DPGAP3 2 T1D T2DPHF7 2 T1D T2DPI4K2A 2 T1D T2DPITPNB 2 T1D T2DPKDCC 2 T1D T2DPLCG1 2 T1D T2DPLCXD3 2 T1D BFAPLD2 2 T1D T2DPLEKHA3 2 T2D BFAPLPP3 2 T1D BFAPLSCR1 2 T1D BFAPODXL2 2 T1D BFAPOLR1D 2 T1D T2DPOMT1 2 T1D T2DPPIL6 2 T2D BFAPPP1R15B 2 T2D BFAPPP2R5C 2 T1D T2DPPT1 2 T2D BFAPRICKLE2 2 T2D BFAPRMT5 2 T1D T2DPROC 2 T1D T2DPROM1 2 T1D T2DPRX 2 T1D T2DPSMD6 2 T2D BFA

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PTP4A2 2 T1D T2DPWP1 2 T2D BFAQSOX2 2 T2D BFARAB1A 2 T1D T2DRAB20 2 T1D BFARANGRF 2 T1D T2DRASGRF1 2 T1D BFARBM20 2 T1D BFARFC2 2 T2D BFARFX2 2 T2D BFARHOBTB3 2 T1D T2DRIN2 2 T2D BFARIOK3 2 T2D BFARND3 2 T1D T2DRNF121 2 T2D BFARP2 2 T1D T2DRPGR 2 T2D BFARRAGA 2 T2D BFARSAD2 2 T1D T2DRTN3 2 T1D T2DRUNX3 2 T1D T2DRXRA 2 T2D BFASACM1L 2 T2D BFASCFD1 2 T1D T2DSDC2 2 T1D T2DSEC11A 2 T1D T2DSEC11C 2 T1D BFASEC14L5 2 T1D BFASECTM1 2 T1D T2DSEPP1 2 T1D T2DSERTAD1 2 T1D T2DSGCE 2 T1D T2DSGMS1 2 T1D T2DSH3GL2 2 T1D T2DSIX5 2 T1D T2DSLC11A2 2 T1D T2DSLC18B1 2 T1D BFASLC1A5 2 T1D T2DSLC23A2 2 T1D BFASLC30A6 2 T2D BFASLC35A2 2 T2D BFASLC35A5 2 T2D BFASLC35C1 2 T2D BFASLC35E1 2 T2D BFASLC6A16 2 T2D BFASLC9A8 2 T1D T2DSLMAP 2 T1D T2DSMAP1 2 T2D BFASMIM13 2 T2D BFASNCB 2 T1D T2D

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SNX17 2 T1D T2DSNX2 2 T1D T2DSNX5 2 T1D T2DSNX6 2 T1D T2DSORT1 2 T1D BFASPATA16 2 T1D T2DSPEF2 2 T1D T2DSPPL2A 2 T1D T2DST3GAL1 2 T1D T2DST3GAL4 2 T1D T2DST8SIA2 2 T1D T2DST8SIA3 2 T1D BFASTC2 2 T1D T2DSTMN2 2 T1D T2DSTS 2 T1D T2DSTX3 2 T1D T2DSTX6 2 T2D BFASTX8 2 T2D BFASVIP 2 T1D T2DSYAP1 2 T2D BFASYNDIG1L 2 T1D T2DSYT17 2 T1D T2DSYTL2 2 T2D BFATAF11 2 T1D BFATAPBP 2 T1D T2DTBC1D5 2 T2D BFATCP11L1 2 T1D T2DTGFB1 2 T2D BFATGOLN2 2 T2D BFATHEMIS2 2 T1D T2DTIAL1 2 T1D T2DTIPIN 2 T1D T2DTJAP1 2 T2D BFATLR5 2 T2D BFATLR8 2 T1D T2DTM9SF1 2 T2D BFATMC6 2 T1D T2DTMC8 2 T1D T2DTMED1 2 T1D T2DTMED3 2 T1D T2DTMEM104 2 T2D BFATMEM130 2 T1D T2DTMEM132A 2 T1D T2DTMEM165 2 T1D T2DTMEM214 2 T2D BFATMEM241 2 T1D T2DTMEM251 2 T1D T2DTMEM41A 2 T2D BFATMEM43 2 T1D T2DTMEM59 2 T1D T2D

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TMF1 2 T2D BFATOM1L1 2 T1D T2DTOM1L2 2 T2D BFATP53I11 2 T2D BFATPD52 2 T1D T2DTRAF3IP2 2 T1D BFATRAPPC2L 2 T1D T2DTRIM69 2 T1D T2DTRIP11 2 T2D BFATSNAX 2 T2D BFATTC33 2 T2D BFATVP23B 2 T2D BFAUSE1 2 T1D T2DUSO1 2 T2D BFAVAMP5 2 T1D T2DVCP 2 T1D T2DVMA21 2 T1D T2DVPS13C 2 T1D T2DVPS54 2 T2D BFAWASL 2 T1D T2DWDR41 2 T1D T2DWDR44 2 T2D BFAWHAMM 2 T1D T2DWNT7A 2 T1D T2DWSCD1 2 T1D BFAYIF1A 2 T2D BFAYIF1B 2 T2D BFAYIPF2 2 T2D BFAYIPF5 2 T2D BFAZADH2 2 T1D BFAZBED9 2 T2D BFAZC3H12B 2 T1D BFAZC3H12C 2 T1D BFAZCCHC4 2 T2D BFAZMYND19 2 T1D BFAZMYND8 2 T2D BFAZNF287 2 T2D BFAZNF461 2 T1D BFAZNF526 2 T2D BFAZNF527 2 T1D BFAZNF576 2 T2D BFAZNF622 2 T2D BFAZNF629 2 T1D T2D

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Supplemental Table

Supplemental Table 1. Primers used for qRT-PCRGene Forward ReverseARF4 CCCTCTTCTCCCGACTATTTGG GCACAAGTGGCTTGAACATACCATF3 GCTGTCACCACGTGCAGTAT TTTGTGTTAACGCTGGGAGACREB3 AAAGTGGAGATTTGGGGACG CGCTCGGTACCTCAGAAAGACTB AGGTCATCACTATTGGCAACGA CACTTCATGATGGATTGAATGTAGTTTaqMan PrimersCOG6 Hs01037401_m1GOSR2 Hs03004084_m1ACTB Hs99999903_m1

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Checklist for Reporting Human Islet Preparations Used in Research

Adapted from Hart NJ, Powers AC (2018) Progress, challenges, and suggestions for using human islets to understand islet biology and

human diabetes. Diabetologia https://doi.org/10.1007/s00125-018-4772-2.

Manuscript DOI: https://doi.org/10.2337/[insert manuscript submission number] (Example, https://doi.org/10.2337/db18-1234)

Title:

Author list:

Corresponding author: Email address:

Islet preparation 1 2 3 4 5 6 7 8a

MANDATORY INFORMATION

Unique identifier SAMN11523048 SAMN11514696 SAMN11982795 SAMN12274306 SAMN13836615 SAMN13938639 SAMN13972304

Donor age (years) 35 59 54 37 58 50 49

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Version 1.0, created 16 Nov 2018

Donor sex (M/F) F F M M M F M

Donor BMI (kg/m2) 33.4 21.8 42.8 25.3 23.2 39.2 34.8

Donor HbA1c or other measure of blood glucose control

137.00 mg/dL 222.00 mg/dL 191.60 mg/dL 192.80 mg/dL 88.60 mg/dL 131.40 mg/dL 161.20 mg/dL

Origin/source of isletsb

IIDP IIDP IIDP IIDP IIDP IIDP IIDP

Islet isolation centre

Sharp Lacy U. Miami U. Wisconsin U. Miami Sharp-LacySouthern California ISRC

Southern California ISRC

Donor history of diabetes? Yes/No

No No No No No No No

If Yes, complete the next two lines if this information is available

Diabetes duration (years)

Glucose-lowering therapy at time of deathc

RECOMMENDED INFORMATION

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Version 1.0, created 16 Nov 2018

Donor cause of death

Warm ischaemia time (h)

Cold ischaemia time (h)

Estimated purity (%)

Estimated viability (%)

Total culture time (h)d

Glucose-stimulated insulin secretion or other functional measuremente

Handpicked to purity? Yes/No

Additional notes

aIf you have used more than eight islet preparations, please complete additional forms as necessarybFor example, IIDP, ECIT, Alberta IsletCorecPlease specify the therapy/therapiesdTime of islet culture at the isolation centre, during shipment and at the receiving laboratoryePlease specify the test and the results

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