, UM1MSc candidate Research on Female Reproduction -

New casesMortalityNew casesMortalityNew casesMortality487.000269.500233.30061.400230.000140.100

New casesMortalityNew casesMortality528.000266.0001.700.000522.000

: 65.500 (2012)

80% 50

Screening

Am I at risk ?

This study found an increased risk for ovarian cancer among infertile women with endometriosis.

Most studies suffer from methodological issues, such as lack of controlling for confounding variables, short follow-up, a limited number of cancer cases, and incomplete data collection.

Buis et al, 2013

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( )

33712

& 4 (4)

4 CA 125 + 4 = CA 125 ( )

Zhang et al, 2016 & Nowak et al, 2015

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:Risk of Malignancy Index (RMI ) RMI = U M CA125

Risk of Ovarian Malignancy Algorithm (ROMA) 94% Copenhagen Index (CPH-I) 78% 87%

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384 women 224 presented a benign ovarian tumor 32 BOT 87 EOC 26 non-epithelial ovarian cancer 15 ovarian metastases. CPH-I performed slightly better than ROMA, and both approached 89% sensitivity and 85% specificity.

When all malignant tumors (EOC, BOT, ovarian metastases and non-epithelial ovarian cancer entire cohort) were included, the performance of CPH-I and ROMA declined to nearly 72%, although the specificity remained close to 85%.

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Screening

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There is no indication that population-based screening has a role in the early detection of endometrial cancer among women who are at average endometrial cancer risk and have no symptoms.

There is also no standard or routine screening test for endometrial cancer.

ACOG & SRU,2015 ESMO, ESGO,ESTRO, 2015

Screening of asymptomatic women for endometrial carcinoma has in general been recommended only for those with LS19

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45 -54 19%55-6432.6%65-7422.6%75-8413.5%

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meta-analysis [35 prospective studies] 6000 women sensitivity TVUS 96% 5 mm was associated with a less than 1% probability

meta-analysis consisted [57 studies] 9031 patients 5 mm cut-off level a positive test result probability of carcinoma from 14-31% a negative test 2.5 % ACOG cut-off