2nd key player for health = Anti-free radical defences, the HSP

Free radicals

2nd link: cellular protection

The neutralisers: enzymes and their cofactors:S.O.D: Cu, Zn, Mn

G.P.X: SeCatalase: Fe

Free radical scavngersVitamins A, C, E, β-carotene,

flavonoides, (diet), etc.

Anti-free radical defenceFree radicals

Cellular aggression and protection:

UV rays, Inflammation, Infection Alteration of structural or physiological proteins (enzymes, hormones, etc.)

2nd key factor for health = Anti-free radical defence system, HSPs

2nd link: cellular protection

Repairing or evacuating proteins(Chaperon)

UV rays, Thermic shock, Inflammation, Infection

Changes in structural or physiological proteins (enzymes, hormones, etc.)

Stress proteins (HSP)

It is also…

Anti-oxidant modelAnti-oxidant model

Fresh fruit and vegetablesSource of carotenoidsHerbs and spices, tea, wine

Dietary advice

Le réflexe Oxybiane

Advice on supplements

Le réflexeProteochoc

Perturbed cellular protection

From the very first symptoms of…

INFLAMMATIONINFECTION

2 situations

Lip and genital herpes

Mouth ulcers

Tooth abscess

Flu-like symptoms Trauma, bruising

Burns, sunburn

Sprains

Joint pain

Regimen: 4 capsules a day for 3 days

Think Proteochoc

Like certain other algae and plants, the seaweed Porphyra umbilicalis can survive under extremely harsh conditions

Porphyral extract was added to the first Oxybiane composition in 1993 (?), for its anti-oxidant and anti-elastase properties.

In 1995, Dr Paul Bringer and Dr Jean-Louis Lichon observed the effects of Oxybiane on dry eyes and cataracts, suggesting that the product, and in particular Porphyral, might have other properties.

About Proteochoc

P.U. type plants and algae are known to have the ability to

synthesise HSP rapidly

= In 1999, PiLeJe became involved in a stress protein modulator development project.

= Meeting with HSP specialist Professor André Patrick ARRIGO* (CNRS LYON 1). He suggested that Porphyral had a HSP-modulating effect.

= Research projects began

*Médecines/Sciences n°1, vol 14, janvier 1998

About Proteochoc

2- Porphyral HSP* reduces UV ray-induced DNA damage

Effects of a Porphyral HSP® extract on the DNA damage induced by UV rays

Ligh

t int

ensit

y (R

LU) a

s a

prop

ortio

n of

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f DNA

lesio

ns

0

200

400

Control without UV

Porphyra 0.1% Porphyra1.3%

1- Porphyral HSP* boosts anti-free radical resistance

0

50

100

150

200

250

300

0 0,1 0,2 0,5 1 2 5 10concentration (g/L)

Global antioxidant potential of Porphyral HSP® - KRL test-

Incr

ease

in a

nti-f

ree

radi

cal r

esist

ance

(%

cont

rol b

lood

)

The different studies

Porphyral HSP

Témoin

Augmentation des HSP 27, 60, 70Plus rapide pour 27 et 60

3- Porphyral HSP* stimulates HSP production after thermal shock

Protocol evaluating the modulatory effects of Porphyra umbilicalis on stress protein synthesis

These studies were presented at the 4th Micronutrition Symposium in March 2002 by Flore MARTIN, head of the scientific department

PiLeJe patents the Porphyra umbilicalis extraction process

under the name Porphyral HSP*