11092015 - P.biofarmasetika - Perhitungan Farmakokinetik

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Non-Compartmental Analysis of Plasma Data after Intravenous Time Unit h Method Linear Trapezoidal Conc Unit μg/ml  Analyst Byantari Prameswari Nyoman Dose !" Date !#$"%$$%& Dose Unit mg Time $'(')(*$ Time Conc ln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 Solver 2.0 0 5 10 15 20 25 0 5 10 15 20 25 30 Time (h)    C   o   n   c   e   n    t   r   a    t    i   o   n    (   μ   g    /   m    l    ) 10 100    C   o   n   c   e   n    t   r   a    t    i   o   n    (   μ   g    /   m    l    )

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Transcript of 11092015 - P.biofarmasetika - Perhitungan Farmakokinetik

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Non-Compartmental Analysis of Plasma Data after Intravenous

Time Unit h Method Linear TrapezoidalConc Unit μg/ml  Analyst Byantari Prameswari NyomanDose !" Date !#$"%$$%&Dose Unit mg Time $'(')(*$

Time Conc ln(C) AUC AUMC R#+" !'+,) *+!#&!!&'', $'+'!""&*,)) *+#&" %#+&!&",""')

$ $+)$ !+&!*)&&#,#, !"+!)#&*,)) $#+'!" %#+&'$*#&$#)*

$+" $'+#, !+)''#'',$$ **+'*#&*,)) !#+,,$!" %#+&""#"$&$,

! ,+& !+#,)&*'$$" *+&"#"&*,)) *#+#*," %#+&,*&&&,&'*

* ,+! $+&"$*#)!! ')+"#"&*,)) '+&*," %#+&,!&')$&

' "+', $+)&&!,)$)' "!+&"""&*,)) ,#+,&," %#+&,)*$#,*$&

" "+$, $+)'!,!)" "+!,""&*,)) &'+))!" %#+&,"$"&,*'$

) '+#* $+*&*,))*,) )!+,""&*,)) $$&+),," %#+&*'$'*&'!

, !+,! $+###)*$#* ))+!"#"&*,)) $'$+!," %#+&&$*&&!#,*

!+)$ #+&"&*"#!!$* )+&$""&*,)) $)$+!'," %#+&&&'*$,$'

$! $+,* #+"'$!$'#" ,,+"&""&*,)) !''+"!," %#+&!,#)$$&*

$) $+') #+*,'*)'*", *+&,""&*,)) **!+,),"!' #+"& %#+"!,)*!,'!$ &!+$,""&*,)) '!+',"

PK Solver 2.0

0 5 10 15 20 25

0

5

10

15

20

25

30

Time (h)

   C  o  n  c  e  n   t  r  a   t   i  o  n   (  μ  g   /  m   l   )

10

100

   C  o  n  c  e  n   t  r  a   t   i  o  n   (  μ  g   /  m   l   )

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0 5 10 15 20 25

0.1

1

Time (h)

0 5 10 15 20 25

0.1

1

10

100

Time (h)

   C

  o  n  c  e  n   t  r  a   t   i  o  n   (  μ  g   /  m   l   )

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 Bolus Input 

Ra!" #arameter Unit $al%e#+"$,",,') Lam-da.z $/h #+#,#,"$"

#+,'))&$$)& t$/! h ,+$*'&!&!)

#+&#*&"&"$)$ Tma h #+"

#+&'!!)##'&* Cma μg/ml !'+,)

#+&*&#"$&#! C# μg/ml *!+&'!*,"#),!

#+&'"*,&,"! Clast.o-s/Cma #+#!*!,")$

#+&'$$!*#* AUC #%t μg/ml0h &!+$,""&*,))

#+&",&*" AUC #%in1.o-s μg/ml0h &+!)))',!"'

#+&,,$)*$'!  AUC #%t/#%in1.o-s #+&*!)&&)*$"

#+&)&&$!!* AUMC #%in1.o-s μg/ml0h2! ,$,+'"#,*),!,$

#+&*$'!!)** M3T #%in1.o-s h ,+!"&),'")

4z.o-s 5mg6/5μg/ml6 &'+$#)'',"''Cl.o-s 5mg6/5μg/ml6/h +*',&'&'*"'

4ss.o-s 5mg6/5μg/ml6 )#+)#*"#,#"!$

30

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30

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Sample Data for Non-Compartmental Analysis of Plasma Data

Time Unit hConc Unit μg/ml  Analyst Byantari Prameswari NyomanDose !" Date !#$"%$$%&Dose Unit mg Time $'('"($#

Time Conc#+" !'+,)

$ $+)$

$+" $'+#,

! ,+&

* ,+!

' "+',

" "+$,

) '+#*

, !+,!

!+)$

$! $+,*

$) $+')!' #+"&

PK Solver 2.0

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fter Intravenous Bolus Input 

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t Cp ln Cp AUC

0 3.486 1.2487549471 2.31225

0.75 2.68 0.9858167945 0.62375

1 2.31 0.8372475245 0.9575

1.5 1.52 0.4187103349 0.62752 0.99 -0.0100503359 0.745

3 0.5 -0.6931471806 0.375

4 0.25 -1.3862943611 0.32

6 0.07 -2.6592600369

AuC 0-ta 5.961

slope -0.65267265

intercept 1.248680958

Cp0= 3.485742082

AuC tak hina !0.07 " slope# -0.10725AuC ta-tak hina 6.068251

AuC $otal

%osis 10000 &ilira& Cl '()k

'( 2868.829582 &ililiter -1.872407

2.868829582 *

+ = AuC ,ral " AuC ' ) % !'# " % !,# )100

0

-3

-2.5

-2

-1.5

-1

-0.5

0

0.5

1

1.5

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AuC inus ti(ak (i&asukkin

1 2 3 4 5 6 7

/!# = - 0.6998613611 1.4664989399 = 0.9976315655

Chart $itle

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a(ar ,at (ala& las&a terha(ap aktu

t !a&#a(ar !u"&l#

:uspensi ,ral neksi ntra;ena ln :uspensi ,ral

0 0 6.135889222 <rr502

0.5 2.75 5.31 1.01160091171 6.24 4.62 1.8309801824

1.5 8.5 4.02 2.1400661635

2 9.81 3.5 2.2834022736

3 7.43 2.65 2.0055258587

4 5.6 2.01 1.7227665977

6 3.19 1.16 1.1600209168

8 1.91 0.66 0.6471032421

>ioa;ailailitas !+# 0.7995359797 + = AuC ,ral " AuC

C ?at Akti/ 100 &"&l50 &"&l

%osis neksi ' 2 &l

:uspensi ,ral 2 s(t 10

,A* @$A'<@A

:lope ,ral -0.2689158389 :lope '

ntercept ,ral 2.7901252857 ntercept '

Cp 0 ,ral 0 Cp 0 '

k 0.2689158389 0.2784125415

AuC 0-ta 39.535 19.7789723055

AuC tak hina 0.2603044889 0.2514254553

AuC ta-tak hina 39.2746955111 19.5275468502

'( %'"0B 32.5951125848

Cl %'"0B -9.0748881355

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ln ' AuC ,ral AuC '

1.81415501 0.6875 2.861472

1.66959184 2.2475 2.48251.53039471 3.685 2.16

1.3912819 4.5775 1.88

1.25276297 8.62 3.075

0.97455964 6.515 2.33

0.69813472 8.79 3.17

0.14842001 5.1 1.82

-0.4155154 -7.64 -2.64

AuC 0-ta 39.535 19.77897

' ) % !'# " % !,# )100

&l

-0.2784125

1.81415501

6.13588922

0 1 2 3 4 5

-1

-0.5

0

0.5

1

1.5

2

2.5

/!# = - 0.2778240768 1.809690149 = 0.9999842469

/!# = - 0.1343017738 2.0366640331 = 0.3549140249

Chart $itle

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6 7 8 9

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@atakan status ioeki;alensi (ari ketia se(iaan kapsul ui !kapsul AD >D (an C# t

:uect

AUC !u"&l .a&#

apsul A apsul > apsul C apsul :$%

1 14.1 19.1 9.6 15.8

2 20.2 20 10.6 19

3 19 17.5 14.6 19.34 13.2 20.3 13.1 18.4

5 13.5 17.3 10.4 17.2

6 17.9 17.4 8.3 16.5

7 12.4 17.2 14.5 17.9

8 15.8 16.9 11.4 17.5

:uect AUC !u"&l .a&#

apsul A +A apsul > +> apsul C +C

1 14.1 89.24051 19.1 120.886076 9.6 60.759492 20.2 106.3158 20 105.263158 10.6 55.78947

3 19 98.4456 17.5 90.6735751 14.6 75.64767

4 13.2 71.73913 20.3 110.326087 13.1 71.19565

5 13.5 78.48837 17.3 100.581395 10.4 60.46512

6 17.9 108.4848 17.4 105.454545 8.3 50.30303

7 12.4 69.27374 17.2 96.0893855 14.5 81.00559

8 15.8 90.28571 16.9 96.5714286 11.4 65.14286

+ ata - ata 89.03421 103.230706 65.03861

:+ 14.9665 9.49569571 10.33253

:+ 5.291459 3.35723541 3.6531

C* / + E :/ ta 79.0069 96.8687452 58.11598

99.06153 109.592667 71.96124

riteria ioeki;alensi C* 80-125

sehina pro(uk > ioeki;alen (enan :$%

untuk pro(uk A ti(ak isa lansun (ikatakan $%A >,<'A*<@ !&en(ekati 80

&enurut usp sarat sa&pel untuk ui ioeki;alen seanak 24 sa&pel

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erha(ap se(iaan stan(ar !:$%#

apsul :$%

15.819

19.3

18.4

17.2

16.5

17.9

17.5

FFFF kriteria ioeki;alensi

a 0D05 1.895

  #D &aka (ilakukan pena&ahan u&lah susta