5/28/2018 1. - 2013

1/23

5/28/2018 1. - 2013

2/23

=

(, , )

(, , )

( ,

, )

F. Serturner

1805

5/28/2018 1. - 2013

3/23

50%

1990 :SA

(spindle poison)

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4/23

5/28/2018 1. - 2013

5/23

/

5/28/2018 1. - 2013

6/23

/

5/28/2018 1. - 2013

7/23

: 19 -20

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8/23

(2000 )

- ( )

- -

- =

Smith (1600 )

Ebers (1550 ): 700

5/28/2018 1. - 2013

9/23

(500 -200 )

(460-377 )-

(57 )

-

5

~ 500

(130-201 )

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10/23

(700-1000 )

Avicenna,

al-kuhl ()

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11/23

,

,

(1493-1541)

Philippus Aureolus Theophrastus Bombastus

Von Hohenheim ()

5/28/2018 1. - 2013

12/23

,

.

5/28/2018 1. - 2013

13/23

William Harvey (1578-1657)

(On the motion of the heart and the blood

in animals)

On the Generation of Animals:

Albert von Haller (1708-1777)

,

567

.

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14/23

William Withering (1741-1799)

,

Oswald Schmiedeberg (1874)

(digitoxin): ,

Jan Baptist Van Helmont (1580 - 1644)

(" ).

"gas" ( )

.

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15/23

Frederick Wilhelm Serturner (1783-1841)

1805:

()

papaver somniferum

5/28/2018 1. - 2013

16/23

Claude Bernard (1813-1878)

(

)

Paul Ehrl ich (1854-1915), Nobel 1909

-

()

-

- 1909:

(, )

-

5/28/2018 1. - 2013

17/23

Heinrich Dreser (1860-1924)

( )

()

Gerhard Domagk (1895-1964),

Nobel 1939

Prontosil ()

,

Daniel Bovet

5/28/2018 1. - 2013

18/23

Daniel Bovet (1907-1992), Nobel 1957

-

()d- - 1

5/28/2018 1. - 2013

19/23

Sir James Whyte Black (1924-2010), Nobel 1988

(-

)

( 2 )

5/28/2018 1. - 2013

20/23

6- 6-

Gertrude Elion (1918-1999)

George Hitch ings (1905-1998) Nobel 1988

, ,

()

- (6-, 6-TG)

- ()

-- ()

"The idea was to do research, find

new avenues to conquer, new

mountains to climb".

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21/23

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22/23

-

( )

()

1, 2, 3

(

Solanaceae, , , )

5/28/2018 1. - 2013

23/23

,

/

: -