:

. papagd@pharm.auth.gr

Tel. 2310-998680

(Radiopharmaceutical) , .

, , , .

, ,

:

He2+

--- e-

+--e+

--

N N

NN

Tc

OH

O

O

99mTc-D,L-HMPAO

N N

NS

O

O

O

COOH

99mTc-MAG3

Tc

O

-

S

N N

S

N

Cl

Tc

O

99m Tc-TRODAT-1

NIn

N

O

N

O

OO

O

O

O

O

HN

O

D-Phe

Cys

Trp-DLys

Thr

Cys

Thr(ol)

S S

-

[131I]NaI

-

- , .

- ( DNA, )

-

( )

(e+)- (2 , 511 keV)

(e+)

(, ) 80-300 keV ( ) (, -)

/

95%

(~ 10-10 )

PETSPECT

15O(+, 123s)15N

13N(+, 9.9m)13C

11C(+, 20.3m)11B201Tl (EC, 74h) 201Hg

18F(+, 109.7m)18O111In(EC, 2.8d, 173keV)111Cd

82Rb (+, 1.2m) 82Kr123I (EC, 13.3h, 159keV)123Te

68Ga (+, 68.3m)68Zn99mTc (IT, 6h, 140keV)99Tc

( ) (SPECT, PET)

SPECT

PET

-

-

-

/

:

( )

65 m-,6.8 7.2 h211t70 m-,7.8 1h212Bi12 mm-, 2.282.67 d 90Y

11 mm0.155, 2.1316.95 h 188Re

8.7 mm-, 1.7114.3 d 32P

5 mm0.131, 1.083.7 d 186Re

3 mm0.103, 0.81.95 d153Sm

2 mm0.36, 0.68.04 d 131I

1.9 mm0.32, 0.571.48 d105Rh

1.8 mm0.185, 0.542.58 d67Cu

1.5 mm0.21, 0.496.7 d 177Lu

(MeV)

(MeV)

, Auger.

LET /

DNA

(> 0.4 Gy/h). 10 h t1/2.

(carrier free)

,

DNA

,

: , , , , , ,

Ammonia (13N) injectionChromium (51Cr) edetate injectionCyanocobalamin (57Co) capsulesCyanocobalamin (58Co) capsulesFludeoxyglucose (18F) injectionFlumazenil (N-(11C) methyl) injectionGallium (67Ga) citrate injectionHuman albumin injection, iodinated (125I)Indium (111In) pentetate injectionIobenguane (123I) injectionIobenguane (131I) injection for diagnostic useIobenguane (131I) injection for therapeutic useKrypton (81Kr) inhalation gasL-Methionine (11C-methyl) injectionNorcholesterol injection, iodinated (131I)Raclopride (11C-(methyl) injectionSodium acetate (1-11C) injectionSodium fluoride (18F) injectionSodium iodide (123I) injectionSodium iodide (131I) capsules for diagnosti use

Sodium iodohippurate (123I) injectionSodium iodohippurate (131I) injectionSodium pertechnetate (99mTc) injection (fission)Sodium pertechnetate (99mTc) injection (non-fission)Sodium phospate (32P) injectionStrontium (89Sr) chloride injectionTechnetium (99mTc) colloidal rhenium sulphide injectionTechnetium (99mTc) colloidal sulphur injectionTechnetium (99mTc) colloidal tin injectionTechnetium (99mTc) etifenin injectionTechnetium (99mTc) exametazime injectionTechnetium (99mTc) gluconate injectionTechnetium (99mTc) human albumin injectionTechnetium (99mTc) macrosalb injectionTechnetium (99mTc) medronate injectionTechnetium (99mTc) mertiatide injectionTechnetium (99mTc) microspheres injectionTechnetium (99mTc) pentetate injectionTechnetium (99mTc) sestamibi injectionTechnetium (99mTc) succimer injectionTechnetium (99mTc) tin pyrophospate injectionThallous (201Tl) chloride injectionWater (15O) injectionXenon (133Xe) injection

>95%

. :

: ) , ) , ) , )

( +

)

( , , )

: , , .

(Instant Thin Layer Chromatography, ITLC) silica

(HPLC)

ITLC

PLC

Rf= cm /cm %

99mTc:

140 kev

6h

99Mo-99mTc

To 85% -99m , , , , , , ..

Mo-99/Tc-99m

Sn2+ +99mTcO4- + H+ 99mTc4+ + Sn4+ + H2O S2O42- + 99mTcO4- + OH- 99mTc4+ + SO32- + H2O

Tc(VII)TcO4-

Tc(V)Tc(IV)Tc(III)Tc(I)

SnCl2, Na2S2O4, HCl, Fe(II), NaBH4,, PPh3

M -99m

1) :99mTcO4- + + L [99mTc-L]

L= , = SnCl2, NaBH4

2) M ) 99mTcO4- + + L [99mTc-L]

L= ) [99mTc-L] + L [99mTc-L] + L

99mTc

: 99mTc ,

().

:

: .

: dl-99mTc-HMPAO

(99mTc-exametazime)

N N

NN

OH

O

Tc

O ~5%

: , [TcO(V)]3+

dl : ( )

(, , Alzheimer )

99mTc-dl-HMPAO

99mTc-d,l-HMPAO

99mTc-meso-HMPAO

99mTc-d,l-HMPAO

dl-99mTc-HMPAO >80% : 2 hr ( ), 4-6 hr

( , ) -

3-5% 5 min 50% 3-4 24 . 12%

( )

41% 48

dl-99mTc-HMPAO 99mTc-d,l-- , . , , - .

dl-99mTc-HMPAO , , ...

Alzheimer

S

N N

N

O

O

O

OH

O

Tc-MAG3

Tc

O

Tc-DTPA

. 1-2 .

90% 24 h 5%-10% 1h.

TcN

N N

O

O

O

O-

O

O

O

O

-O

O

Tc(V), ,

3-5 min

.

- , -, , .

'

.

99mTc-Sestamibi

C

CC

CC

N

Tc

C

N

NN

N N

OCH3

OCH3

OCH3

OCH3

H3CO

H3CO

+ , Tc +1 1,5% 1,2%

SPECT Imaging of Heart

Cardiac Ischemia

Tc-99m-sesta-mibi stress test

Tl-201 rest

O/ , 99mTc-MDP

70% .. Ca10(PO4)6(OH)2

P

P

OH

OH

O

OP

P

OH

OH

O

O

TcO

O O

O

OH

OH

HO P O P OH

O O

OH OH

HO P C P OH

O O

OH OH

X

Z

,

, =, MDP, =, =, HDPX=OH, Z=Me, HEDP

Tc-99m-MDP

99mTc-MDP

PP

OOHOHHO

O

OH 40-50% 3-4 hrs

: , , .

: , ,

186/188186/188ReRe--HEDPHEDP

(69% ): Ca10(PO4)6(OH)2

186Re: (t1/290,6 h, - =1, 075eV, 137 eV) 185Re(n,) 186Re188Re: (t1/217 h, - =2,11eV, 155 eV) 188W/188Re

186/188186/188ReRe--HEDPHEDP::186/188186/188ReOReO44-- + SnCl+ SnCl22 + HEDP + HEDP 186/188186/188ReRe--HEDPHEDP

:

710 710 keVkeV --/ / 103 103 keVkeV (5 %)(5 %)TT1/21/2: 46 hrs : 46 hrs 47-77% 153Sm-EDTMP . 16:1. Sm-153-EDTMP , 88-90% 98% 4 . QUADRAMET QUADRAMET . . 3 3--4 4 QUADRAMET. QUADRAMET.

QUADRAMET 153153SmSm--EDTMPEDTMP

: Na99mTcO4 99Mo-99mTc. 12

, Tc-99.

. :

-: 15-20 min iv .

70-80% , 20-30% , , . .

. : 18.5-80 q.

a131 p.o. 6-24 h .

:

I-123 EC (100%), T1/2= 13.2 hr, = 159 KeV (83%)

I-125 EC (100%), T1/2= 60 d, = 35 KeV(7%)

I-131- (100%), T1/2= 8 d, = 284 (6%), 364 (81%), 637(7%)

aa123/131123/131I.I.

Na131I , Natrii iodidi (131I) capsulae ad usumdiagnosticum, Natrii iodidi (131I) capsulae ad usum therapeuticium, Natrii iodidi (131I) solutio

> 99.9% .

: -133, -135, a3 Per os :

3 hr. 90% , 50% 24 h 10-35 % 24 h pi

X: , , .

[[1818F]F]--FDGFDG

[[1818FF]]--FDGFDG

, , ,

, , , ,

[[1818F]F]--FDGFDG