Πότε και πώς...

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  • ...15 | 3-5 2016

    *Geen tekst: alleen laten zien

  • :

  • %

  • 1979 Sulfasalazine, 1980 , , 6-MP19935-ASA199419951998Infliximab20042

  • Anti-TNF

    Infliximab (Remicade) - Crohns & UCAdalimumab (Humira) - Crohns & UCCertolizumab (Cimzia) - Crohns Golimumab (Simponi) - UC

    Natalizumab (Tysabri) - Crohns Vedolizumab (Entyvio) - UC > Crohns

  • http://synapse.koreamed.org/ArticleImage/0143IR/ir-10-26-g003-l.jpg

  • http://synapse.koreamed.org/ArticleImage/0143IR/ir-10-1-g001-l.jpg

  • Infliximab (IFX) IgG1 (75%) (25%) TNF- DNA

  • IFX

    Crohn / ,

    , , 6-MP AZA,

  • IFX

    Crohn, , IFX Crohn , IFX 3 (6 )

  • IFX , IFX :

    10 mg/kg ( 5 mg/kg) 4 wk ( 8) , 90%

    H IFX , IFX IFX , IFX

  • Adalimumab (ADA) IgG1 TNF- (hamster) DNA

  • ADA

    Crohn , / ,

    6-MP AZA,

  • ADA

  • :

    80 mg 2 wks 40 mg

    Crohn, 12 , ADA

    , 8 , ADA

    ADA

  • Certolizumab pegol, TNF-,

  • Golimumab IgG1 DNA

  • Golimumab

    Crohn

    6-MP AZA,

  • Golimumab (0,5 mL 50 mg golimumab)

  • Golimumab
  • Natalizumab, -4-

  • Vedolizumab IgG1 47 K (hamster)

  • vedolizumab

    Crohn Crohn, , anti-TNF-

    , anti-TNF-

  • Vedolizumab

  • Crohn, vedolizumab 300 mg 4 wk

    Crohn , wk 14

    , wk 10

    Vedolizumab

  • SONIC ( Crohn) SUCCESS ( ): IFX+AZA IFX ( / )

    , ( Crohn) anti-TNF

    Danese S, et al. Nat Rev Gastroenterol Hepatol 2015 (in press)

  • ECCOLink: http://peptiko.gr Crohn

  • * (DDW 2016)*

    (EBV, HIV, CMV, HSV, HBV, HCV, HPV, VZV)(Strep, Staph, Mycobact)(HistoplasmosisCoccidiosis)C. difficileStopMay need to stop +Rx virus

    Individualize who to restart 6MP/AZAStop +RxThen individualizeStop +RxThen restart when clearedContinueAnti-TNFContinueProb ok to continue, except active hepBStop +RxThen individualizeStop +RxThen restart when clearedContinueAnti-ContinueContinueContinueContinue

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