Μελέτη και τεκμηρίωση των τοπικών ποικιλιών στην...

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Μελέτη και τεκμηρίωση των τοπικών ποικιλιών στην Ήπειρο«ΜΟΡΙΑΚΗ ΤΑΞΙΝΟΜΗΣΗ ΚΑΙ ΤΑΥΤΟΠΟΙΗΣΗ ΓΗΓΕΝΩΝ ΠΟΙΚΙΛΙΩΝ ΑΜΠΕΛΟΥ ΤΗΣ ΗΠΕΙΡΟΥ»

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  • : : 1. (, : DeK 1-5), 2. (, VoK 1-5), 3. (, DoK 1-5), 4. (, : MaK 1-3, MaM 1-2), 5. (, BaK 1-5), 6. (, GuM 1-5), 7. (, DeM 1-5), 8. (, PyM 1-5), 9. (, EaM 1-5), 10. (, Bl 1-5) 11. (, BeZ 1-5).

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    DeM1 0.613 0.202 0.398 0.030

    DeM2 0.472 0.175 0.394 0.023

    DeM3 0.515 0.220 0.449 0.033

    DeM4 1.017 0.370 0.804 0.034

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    26

  • EaM1 1.277 0.467 0.990 0.037

    EaM 1.053 0.313 0.668 0.028

    EaM3 1.137 0.330 0.729 0.021

    EaM4 0.780 0.278 0.626 0.018

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    BaK1 1.328 0.548 1.292 0.022

    BaK2 1.304 0.583 1.257 0.031

    BaK3 1.418 0.637 1.345 0.019

    BaK4 1.210 0.520 1.138 0.015

    BaK5 1.371 0.613 1.315 0.018

    DeK1 1.408 0.564 1.315 0.020

    DeK2 1.487 0.716 1.551 0.018

    DeK3 1.801 1.180 1.873 0.024

    DeK4 1.721 0.913 1.777 0.023

    DeK5 1.212 0.486 1.099 0.022

    GuM1 1.138 0.435 1.007 0.025

    GuM2 1.425 0.622 1.383 0.031

    GuM3 1.223 0.536 1.221 0.027

    GuM4 0.846 0.336 0.771 0.020

    GuM5 1.503 0.672 1.509 0.023

    DoK1 0.724 0.189 0.377 0.018

    DoK2 0.888 0.313 0.704 0.015

    DoK3 0.811 0.275 0.595 0.030

    DoK4 0.928 0.329 0.743 0.023

    DoK5 0.694 0.249 0.581 0.014

    VoK1 1.799 1.116 1.879 0.013

    VoK2 1.735 1.011 1.851 0.017

    VoK3 1.256 0.529 1.270 0.016

    VoK4 0.655 0.253 0.615 0.013

    VoK5 0.711 0.240 0.591 0.013

    27

  • PyM1 1.119 0.428 0.919 0.019

    PyM2 1.348 0.497 1.015 0.026

    PyM3 1.268 0.493 1.061 0.039

    PyM4 1.762 0.838 1.597 0.031

    PyM5 1.174 0.456 1.004 0.012

    MaK1 1.463 0.601 1.311 0.019

    MaK2 1.263 0.516 1.206 0.013

    MaK3 1.090 0.420 0.952 0.016

    MaM1 0.903 0.299 0.713 0.011

    MaM2 1.056 0.417 0.938 0.014

    :

    1. 2.

    .

    2

    ITS (Baldwin, 1992):

    : 0,5 gr / DNA Mylona, A, et al. 2008. 100-150 ng DNA (Polymerase Chain Reaction PCR, Saiki, R.K., et al., 1988), ITS. VvF (GTCGCGAGAAGTCCACT GAA) VvR (TCCGGACTACAATTCGGACG), GenBank (Vitis vinifera contig VV78X177628.4, whole genome shotgun sequence. GenBank: AM462492.2). (KAPA HiFiTM,

    28

  • KAPABIOSYSTEMS, Boston, MA, USA). ( PCR) Geneclean (MP Biomedicals, Solon, USA). 50 ng DNA (CeMIA, Larissa, Greece). BLAST (Altschul et al. 1997) ClustalW (EBI, EMBL). : 3 (1% , 1XTAE), .

    3: : : 1 and 15: 2.0 l 100 bp , 2: DeM1 [1.0 l], 3: DeM2 [1.0 l], 4: DeD1 [1.0 l], DeD2 [1.0 l], De26 [1.0 l], GuM1 [1.0 l], De1 [1.0 l], De2 [1.0 l], DoM1 [1.0 l], DoM2 [1.0 l], DoM3 [1.0 l], BaK2 [1.0 l], BaK1 [1.0 l]. .

    29

  • 4. 4 5. 4 , 5, . 4:

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    1 Bl1 97% Vitis vinifera contig VV78X076350.4 2 Bl2 - No significant similarity found 3 Bl3 95 % Vitis vinifera contig VV78X076350.4 4 Bl4 - - 5 Bl5 - - 6 VoK1 76 % Vitis vinifera contig VV78X177628.4 7 VoK 2 86 % Vitis vinifera contig VV78X177628.4 8 VoK 3 78 % Vitis vinifera contig VV78X177628.4 9 VoK 4 76 % Vitis vinifera contig VV78X082551.7 10 VoK 5 81 % Vitis vinifera contig VV78X082551.7 11 DeK 1 86 % Vitis vinifera contig VV79X005930.2 12 DeK 2 89 % Vitis vinifera contig VV79X005930.2 13 DeK 3 88 % Vitis vinifera contig VV79X005930.2 14 DeB 1 84 % Vitis vinifera contig VV79X005930.2 15 DeB 2 80 % Vitis vinifera contig VV79X005930.2 16 DeB 3 79 % Vitis vinifera contig VV79X005930.2 17 DeM4.6 82 % Vitis vinifera contig VV79X005930.2 18 DeM 22 81 % Vitis vinifera contig VV78X082551.7 19 DeM 24 79 % Vitis vinifera contig VV79X005930.2 20 DeM 26 79 % Vitis vinifera contig VV79X005930.2 21 DeM 27 84 % Vitis vinifera contig VV79X005930.2 22 DeMo 1.2 97 % Vitis vinifera contig VV78X177628.4 23 DeMo2 82% Vitis vinifera contig VV79X005930.2 24 DeD 1 87 % Vitis vinifera contig VV79X005930.2 25 DeD 2 94 % Vitis vinifera contig VV78X177628.4 26 GuM 13 81 % Vitis vinifera contig VV79X005930.2 27 GuM 16 89 % Vitis vinifera contig VV79X005930.2 28 GuM 21 85 % Vitis vinifera contig VV79X005930.2 29 MaK 1 93 % Vitis vinifera contig VV78X177628.4 30 MaK 2 94 % Vitis vinifera contig VV78X076350.4 31 MaK 3 92 % Vitis vinifera contig VV78X076350.4 32 MaK 4 - -

    30

  • 33 MaK 5 84 % Vitis vinifera contig VV79X005930.2 34 PyM 1 82 % Vitis vinifera contig VV79X005930.2 35 PyM 1.3 80 % Vitis vinifera contig VV79X005930.2 36 PyM 2.3 79 % Vitis vinifera contig VV79X005930.2 37 PyM 3.4 76 % Vitis vinifera contig VV78X082551.7 38 PyM 4.8 80 % Vitis vinifera contig VV78X082551.7 39 DoK 1 76 % Vitis vinifera contig VV78X082551.7 40 DoK 2 89 % Vitis vinifera contig VV78X082551.7 41 DoK 3 81 % Vitis vinifera contig VV79X005930.2 42 BaK 1 96 % Vitis vinifera contig VV78X076350.4 43 BaK 2 85 % Vitis vinifera contig VV78X177628.4 44 BaK 5 70% Vitis vinifera contig VV78X082551.7 45 BeZ 1 95 % Vitis vinifera contig VV78X177628.4 46 BeZ 2 87% Vitis vinifera contig VV79X005930.2 47 BeZ 3 94 % Vitis vinifera contig VV78X177628.4 48 BeZ 4 - No significant similarity found 49 BeZ 5 83 % Vitis vinifera contig VV78X177628.4 50 EaM17 97 % Vitis vinifera contig VV78X082551.7 51 EaM18 97 % Vitis vinifera contig VV78X076350.4 52 EaM20 88 % Vitis vinifera contig VV78X082551.7 53 EaM22 96 % Vitis vinifera contig VV78X082551.7 54 EaM25 85 % Vitis vinifera contig VV78X177628.4

    4 ITS 1 2 Vitis vinifera GenBank. , .

    31

  • 4: ITS . .

    32

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    33

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    34

  • Altschul S.F., Madden T.L., Schffer A.A., Zhang J., Zhang Z., Miller W., Lipman D. (1997). Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res, 25: 3389-3402 Baird N.A., Etter P.D., Atwood T.S., Currey M. C., Shiver A.L., Lewis Z.A., Selker E.U., Cresko W.A., Johnson E.A. (2008). Rapid SNP Discovery and Genetic Mapping Using Sequenced RAD Markers. PLoS ONE 3(10): e3376. doi:10.1371/journal.pone.0003376. . 2003: , . Baldwin, G.B. (1992). Phylogenetic Utility of the Internal Transcribed Spacers of Nuclear Ribosomal DNA in Plants: An example from the Compositae. Molecular Phylogenetics and Evolution, 1(1): 3-16. Biniari, K. and M.N., Stavrakakis (2007). Genetic study of 46 Greek grape cultivars by random amplified polymorphic DNA markers (RAPD-PCR). th OIV World Congress (Budapest 10-16 June 2007). Drosou, M. (2010). Ampelographic description of some varieties (Vitis vinifera L.) cultivated on the island of Thera. [MSc. Thesis, Department of Plant Production Science, Agricultural University of Athens, Athens, Greece. Fischer U., D., Roth, and M., Christmann. (1999). The impact of geographic origin, vintage and wine estate on sensory properties of Vitis vinifera cv. Riesling wines. Food Quality and Preference, 10: 281-288. Halstead, Paul. (1995). , . - . Kotinis X., 1985. [Ampelographic Atlas of Greece, Greek with French summary], Athens: Ministry of Agriculture, Republic of Greece. Lefort F. and K.A., Roubelakis-Angelakis. (2000). The Greek Vitis Database: A Multimedia Web-backed Genetic Database for Germplasm Management of Vitis Resources in Greece. Journal of Wine Research, 11(3): 233-242. Mylona, A., K. Piliou, I. Smyrnioudis, and E. Hatziloukas. Molecular taxonomy of morphologically diverse cultivars of Pistacia lentiscus Var. Chia. (2008) The FEBS Journal, 275 (Suppl. 1): 361 Ntavidis O.X., 1982. (). . . [Greek Grapevine Studies, Band 3, Elements of Ampelography, 2nd edition, Athens: Agricultural College of Athens.

    35

  • Saiki, R.K., Gelfand, D.H., Stoffel, S., Scharf, S.J., Higuchi, R., Horn, T., Mullis K.B., and Erlich, H.A. (1988). Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science. 239: 487-491. Sambrook, J., and D.W., Russell. (2001). Molecular Cloning. A LABORATORY MANUAL (3rd EDITION). Cold Spring Harbour Laboratory, Cold Spring Harbor, New York, USA. , 2000. , Olive Press. . 2010: , . N., ., A., E., ., ., ., ., ., ., . A., 2006. : . , , . http://www.minagric.gr/Greek/data/NatReport-2006_FAO_PGR_greek_final.pdf. . , 2010: , . Stavrakakis M.N, K., Biniari, and P., Hatzopoulos. (1997). Identification and discrimination of eight Greek grape cultivars (Vitis vinifera L.) by random amplified polymorphic DNA markers. Vitis, 36: 175-178. Thomas, M.R., S. Matsumoto, P. Cain, and N.S. Scott. (1993). Repetitive DNA of grapevine: classes present and sequences suitable for cultivar identification. Theoritical and Applied Genetics, 86: 173-180. http://el.wikipedia.org/wiki/%CE%96%CE%AF%CF%84%CF%83%CE%B1.

    36

  • : ITS . >BlZ1 ATASSGGSCCSAWTYYMGGYTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCGTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGTGT >BlZ2 GGGAGGGTAAGAATTCCAKAACTAGTGTTKTCTCGWAGTMTWAACGCATTAAAAAGGGAAGAYATGCCTATTCTTTCTCCTACCAACTTCTGCTATTGMAGCTGAAAACCCAYAAACCTATCATTGMCCCARATCRRGAGTTACACACACAGCCASATTTGGACTGGACAMTTGGATGTTTTTTTATTKATTTGAGCTGTTMCRATTAACYTACGAACCTCMAACTTCCCACTGCATTCGTTGWAAACCYTTTAGAGCAATTTCACCATACAAAATCTCCTYTCTAGAGTAATASTCCTTGTTTTTCTACAAATTMATTCWTTATC >BlZ3 AGCAAGCGATCTMGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGTGTGGGGGG >BlZ4 ARTYRMMGCGATCYAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGWGTGGKKKGACCTGGCCCTWAWTGAAATKGGGMAAAAACTCACAGCCCGGAAAWGAGGGGGTYTAAGGAA >BlZ5 GRWWMRRMMGRMRGATYTCAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGTGTGGGGGGRCGAMGGTTTTKTTTMACYCWGGKAGGAATKCCCTYGSCMTAATTGATTGGATKCAAGAYTTG >VoK1 GTCGGACCGATCTCAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGRCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSMGGGSGMGGGGSSTSKGGGGGGAGGGAGGKGK

    37

  • GGGGGGGCSACGGGWGGSKGGCCCCCRGGCTRGYGKGTCCTCGGSCTAATGGCTTCCGGCGACTCTTGGATTCAAAGAATTCTTGATTTCCGGGATTCTGCAATTTTTTGCTACKATCTTCTTTTGCTCCAGACTTTATCTATGCGATAGCCAAAATATYCTGTGTCKAGAGAAAYTAGKATTAGGCGAAAASACGACSAATCCCCAACGGGSCCAATCGAGACCGGKGCTACGGTAGGACGTTGCTTGGYTGGGAGGKTSCTTGGSKCCKTCCKTCSCTCGAKACGGTCKTCGCTCGACASCGCCGGCSCGTGCSSSCSGCASSACGTGCGCSGGGSATCACGGCGSCTCGCGATCCSGGGGACTCCCGAACGGGGGGAGGG >VoK2 AMMTTWRRRWAGGAGGAGAAGTCGTAACAAGGTTTCCGTAGGTGAACCTGCGGAAGGATCATTGTCGAACCTCCGAACGACCCGCGAACACGTTACAACTCACCGAGGGGGGGCGGAGMGCGGGSGCGAGCCCGTCKCCTCCGTCGCCCCTCCCCCCGTTCGGGAGGCCCCSGGAGCCCCSCCCSCCGYCKYGCCCCGCGCACGGGSGGGGGGSGGSCCGCGGSGGSCCTCTCKAGCGAACAACRAACCCCGGCGCGGAACGCGCCAAGGAACCTCACAACRAARCAACGCGCTCCCGTCKCCCCGGTCCCGATCGGGSGCGTCGGGGGGKCGTCGTCGTTTCACCAAAMACAAACRACTCTCGGSAACGGATATCTAGGCTCTCKCATCKATGAARAAMGTAKCAAAATGYGATACTTGGKGTGAATTGCAGAATCCCGTGAATCWTCKAGTCTTTGAACGCAAGTTGCGCCCGAARCCATTAKGCCGAGGGSACGCCTGCCTGGGSGTCACGCACCCGTCGCCCCCCCACACCTCCCTCCCCCCCGAAGSCCCGCGCCCGGGGACGGGAGGMTWAGAGGGGGCGGASATTGSCCTCCCGCGGGTGCCCCARACCSCGGTTGGCCGAAAATCRGTCCCCCGGCAACGTACGACTCRACGAGCGGSGGATTTCYCACGGCTCGGCGTCYTGWGCGTKACSCCKCCTCARGGGCCCCCCACKAGAAAGGWCCAAGACCCTCTATGKCGACCCCMGGTCAGGGGGACCCCCCTCTGAGATTTAASATATCAAAAAAYGGAAGGAAAASAMATTTTCAMGGMTTTCCCTKTMGCGGSGAGCGATTTKGGAAWAGYSCGGSTTARATTCGWCRKKYCAACRTCATTCCTGACCTTACTACAMTTTAASCCTYAAT >VoK3 CCTWMYTAAAAGGAGGAGAGTCGTAACAAGGTTTCCGTAGGTGAACCTGCGGAAGGATCATTGTCGAACCTCCGAACGACCCGCGAACACGTTACAACTCACCGAGGGGGGGCGGAGMGCGSGSGCGAGMSCSYSKCCTCCSYCKCCCCTCCCCCCGTTCGGGAGGSCCCSGGAGCCCCSCCCSCCSYCKYGYCCCGCGCRCGGGSGGGGGGGGGSCCGCGGSGGSCCTCTCKAGMGAAMAAMRAAMCCCGGSGCGSAAARCGCCAAGGAACCTCACAACRAARMAACRCGCTCCCSTCKCCCCGGKCCCGATCGGGCGCGTCGGGGGGGCGYCGYCKTTTCACCAAAMACAAACRACTCTCKSSAAMRGATATMTAKGSTCTCKCATCKATGAAAAAAGTAKMAAAATGYGATACTTGKKGTGAATTGYRSAATCCCSTGAATCATCKAGTCTTTGAACRCRAGTTGCGCCCSAAAMCMTTAKGSCSAGGGSACGCCTGYCTGGGGGTSWCGCACCCSTSKCCCCCCCACACCTCCCTCCCCCCCGAGGSCCCGCGCCCGAGGAGGGGAGGMGWAGAGKGGGSGGAGATTGSCCTCCCGCGGGSGTCCCAGACCSCGGKTGGCGSARAATCRGKCCCCCGCMGGCGTAGGCYACRACGAGMGGTGGATTTYYCACGGYTYGGTGTCGCSMGCGGCTCYTCKCCTCAGGGGCCCCCCACACTAKAGGTCSGAGACACTYKATGKGGAMCCCCCGKCTGAGGGTAYACTCTCTGAGTTAYAGATATCMATAATCGTATGAGAKTAGKCTTWTAKGGAGTCCCWTTCSCCGRKCCCCYCMACTTGAAAKTMGCAGSTTTTGTGTCTCTCCTTGAAGGCTATCTCTRTAAACGCATCCCTCTAACCCAATGG >VoK4 CTTWSAGKAAGGAGAAGTCGTACAAGGTTTCCGTAGGTGAACCTGCGGAAGGATCATTGTCGAACCTCCGAACGACCCGCGAACACGTTACAACTCACCGAGGGGGGGCGGAGMGCGSGSGCGMGMSCSYSKCCTCTSTCKCCCCTCTCCCCGTTYGGGAGGSCCCSGGAGACCCSCCCSCCSYSKYGYGCCGCGCACGGGGGGGGGGGGGSCCSCGGSGGSCCTCTCKAGMGAACAAMRAAMCCCGGSGCGSAAARCGCCMAGGAACCTCTCAACRAARMAMCRCGCTCTCSTSKCCCCGGGCCCSATAGGGGGCGTSKGGGGGGGGYCKYSKTTTCWCMMAAMACAAACRASTCTCTSSRACRGATATCTATGSTCTCTCATCTATGAAAAAAGTRKMRMAATGYGATACTTGKGGTGAATTGTGSAATCTCGYGAATCATCKAGTCTTTGAACACRAGTTGTGCCCGAAAACMTTAKGSCSAGGGSACRCCTGTGTGGGGGTSWCRCACM

    38

  • CGTSKCCCCCCCACACCTCTCTCTCCCCKAGGRCCCGCGCCCGAGGACAGGAGGMGWAKAGWGGGCGGAGATWGYCSTCTCGTGGCGTGCCAGMYGTGGTGKCGGAGATCGCTCCCCRCMGAGTACGCSACGACACGCGYGATATCCACMGCTCTRCGTCKCGYGCGTCWCRTCWCTGAGAGSCSCACAGACRKCGAGASCTCGATGCGACCAGTCWGCGGACACTCTSAGTTASATTCATAGCGAGAAKAMCTACAGRTSCCTATRGAKSAGCACTGAAGCYAGCTSATCGSAGYACKCTSCATGCTRCTGARTTASAT >VoK5 CCMTAAAGGAGAGAGTCGTACAGGTTTCCGTAGGTGAACCTGCGGAAGGATCATTGTCGAACCTCCGAACGACCCGCGAACACGTTACAACTCACCGAGGGGGGGCGGAGMGCGSGGGCGAGMCCSTCKCCTCCSTCKCCCCTCCCCCCGTTYGGGAGGSCCCSGGAGACCCGCCCSCCGYCKYGYCCCGCGCACGGGSGGGGGGSGGSCCSCGGGGGSCCTCTCTAGMGAACAACRAAMCCCGGSGCGSAACGCGCCMAGGAACCTCACAACAAAAMAACRCGCTCCCSTCKCCCCGGTCCCSATCGGGSGCGTSGGGGGGTSGTCKTCKTTTCWCCMAAMACAAACRACTCTCTSSAACRGATATCTAKGSTCTCTCATCKATGAAAAAMGTRKMAAAATGYGATACTTGKKGTGAATTGTRSAATCCCSTGAATCWTCTAGTCTTTGAACRCAAGTTGTGCCCGAAAMCATTTTGCCGAGGGSACRCCTGTCTGGGSGTCACGCACCCGTSKCCCCCCCACACCTCTCTCTCCCCCKAGGRCCCGCGCCCGGGGACAGGAGGATTAGAGRCGGCGGAGATTGGCCTCCCGCGGGCGCCCCAGACCGCGKTTGGYCRAKAAATGGTCCCCCGCYGACGCACGCCTCGACAAGAGTYGRATTTCKCACMGYTCYGMGTCKCSMGCGTYACGWCAASACAAGGGSGCCCGACAATATAGGTCGTMTACYYTCTATAGGGATAGCKTGTGTKATGKTACYCCCCCTSRATTTAAGARTATCAAGAAGKKRTAGTKKTTTYTTTKTTTAWGGGGTGASGATTTTAGAKATWTCAAAAYGCSRATWCTCCTWWTTYMGTYTSWYTGWTGATCTMTCTYTGATAWGGWSTCSTSSCYTSKATYAGAGT >DeK1 GGGGGSSSAAWTYYMGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCGTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGRSSTSKGGGGGGRSGRMGG >DeK2 GGGGAACWAACCCYASMTGGGAGGCTTCTACGGYCRGTCGCCATTCTACGGCTAASGTGAAGGGTTTGCTTTKGATTAATTACWCGATGCTTAAGCCACCCCAAAAGCTGTGATCTGGACTGGCGGCGGGGTTTTCACCAGTACYTTCCAGGCTGCCAGGTCRCGGKGCACCAAGCGACGGTCCTCCAASTARTTCATGCCCTGAAACAAAGAARACCCTGCTGTGAGGGACAGATCATCMTGGGAAGAARCTCTGCATCCGAATAAMCYYCM >DeK3 AGGATCTAGGCCGAAYTMGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCGTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGTGTGGGGGGGCGACGGGTGCGTGACGCCCAGGCAGGCGTGCCCTCGGCCTAATGGCTTCGGGCGCAACTTGCGTTCAAAGACTCGATGATTCACGGGATTCTGCAATTCACACCAAGTATCGCATTTTGCTACGTTCTTCATCGATGCGAGAGCCTAGATATCCGTTGCCGAGAGTCGTTTGTGTTTGGTGAAACGACGACGACCCCCCGACGCGCCCGATCGGGACCGGGGCGACGGGAGCGCGTTGCTTCGTTGTGAGGTTCCTTGGCGCGTTCCGCGCCGGGGTTCGTTGTTCGCTCGAGAGGGCCGCCGCGGGCCGCCCCCCGCCCGTGCGCGGGGCACGACGGCGGGCGGGGCTCCCGGGGCCTCCCGAACGGGGGGAGGG >DeB1

    39

  • AGGGCCCCRKWWTYWYMGYTGGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSMGGGGGMGGGRGSTSKGGGGGGRSGRMG >DeB2 ATCGTACGATCTCAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSMGGGGGMGGGRGSTSKGGGGGGRSGRMGG >DeB3 AACGGCSSCAWWWWCMRMTTCGGMTCTTCCGGTTSGCTCGCCGTTACTAGGGGAATCCTTGKAAGTTTCTTTTCMTGTGGAAAGGGKAKGCTTAAACTCAGCGGGKGGKCCCGCCTGRCCTGGGGTCGSGATCGAGGGTCTCGGGYCKTTCTCGTGGGGGGCCCCTGAGGCGATTGACGCGCGCGACGACGAGCCGTGCGAAATCGACCGGTCGTCGWGGCGTACGTCGWTTCGGGACCGATTTTCTTCCACCAGCGAGCTGGTWCGCCCCCGGTAAGCCACAGTGCGCCCCCMCTCCGCCTCCCGACTGGGGGGGGGGGGGGTTTGGGGGGAAAAATGGMGGAAAGACGACTCTTAMATATTTCATTCCCWGTTGRAMCTGGTCCAGGGGAAARTTTCTAGGAAAGCCGAGGGTGACACCCCCCCGCCSGARGGGGGGACGAWTTRTGTTTATGTTTTTATACCGACCCCKTGCTTTKGGAGAAGGCTTTGAGCCTTCTCCCACTTATTAAAAAACCCGGCCGGGAATTCCCTCATTAATTTTGTTTGTCCGCCAGAAAAAGGGGGAARAAWAYAASCCCGCGTKGTTATTTYAATAAAKGCCCCCCCGCAWGGTTSCCTGTTGTTTTATTTAATATAGAGYTCWTTCCTTATCCTWTKTGCTGTTACAAAAAAAATATGARATGRGGSATTTTTGTTTSTSTTTTTCRTATASAGATAAGMTTGMTATTCCKACYCCRCCKMGACYTAATACWRTAAGRGGRTATGRTTKTTTCWTTTTTTATGRGGKGAGGATTYTAGAAATTATAAAAATCCCSAWYCCYCCWTMTCCCCKTAAATTKMTTATTATATTCTGGAWCGAGCTCCGGGCTCTCTGTSKTG >DeM4.6 GTGCCGATCTCAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSAGGGGGAGGGRGGTGKGGGGGGGSGRMGGGKGSGKGRCGCCCMGGSAGGSGKGCCCYCGGSCTAATGGSTTCGGGSGCAACTTGCGTTCAAAGACTCKATGATTCACGGGATTCTGCAATTCMCACCAAGTATCGCATTTTGCTACGTTCTTCATCGATGCSAGAGCCTARATATCCGTTGCCSARAGTCKTTTGTGTTTGGTGAAACGACGACKACCCCCCGACGCGCCCRATCGGGACCGGGGCGACGGGAGCSCGTTGCTTCGTTGKGAGGTTCCTTGGCGCGTTCCGCGCCGGGGTTCGTTGTYCGCTCGAGAGGGCCGCCGCGGGMCGSCCCCCSCCCGTGCSSGGGGCASGACGGSSGGSGGGGMTCCCGGGGSCTCCCSAACSGGGGGAGGGGSGA >DeM22 GTCGTTCGATCTCAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGRCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSMGGGGGMGGGRSSTSKGGGGGGRSGRMGGGKGS

    40

  • GKGASGCCCMGGSAGGSGKGCCCYCGGSCTAATGGSTTCKGGSGCAACTTGCKTTCAAAGACTCKATGATTCACGGGATTCTGCAATTCMCACCAAGTATCGCATTTTGCTACGTTCTTCWTCGATGCSAGAGCCTAGATATCCGTTGCCSARAGTCKTTTGTGTTTGGTGAAACKACGACSACCCCCCRACRCGCCCRATCSGGACCGGGGCGACKGGAGCGCGTTGCTTCGTTGKGAGGTTCCTTGGCGCGTTCCKCGCCKGGGTTCGTTGTYCGCTCGAGAGGGYCGCCGCGGGMCGCCCCCCSCCCKTGCKYGKSGYACGACGGCMGGSGGGGYTCCCKGSGCCTCCCSATCSGWGGGAGGGGSGAATW >DeM24 ATGGCCCGATCTCAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGRCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSAGGGGGMGGGRGSTGKGGGGGGRSGRMGG >DeM26 GAGGCCGAWCTCAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCGTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSAGGGGGAGGGAGGTGTGGGGGGGC >DeM27 AKKKSMGGRMAMKMAAWMWAGCTGSGCTCTTSCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSAGGGGGAGGGRGGTGKGGGGGGGSGACGGGKGSGTGACGCCCAGGSAGGSKTGCCCTCRGSCTAATGGSTTCKGGSGCAACTTGCKTTCAAAGACTCKATGATTCACGGGATTCTGCAATTCACACCAAGTATCGCATTTTGCTACGTTCTTCATCKATGCSAGARCCTAGATATSCGTTGCCSARAGTCGTTTGTGTTTGGTGAAACTACKACKACCCCCCRACRCGCCCGATCGGGACCGGGGCGAAKGGAGCGCGKTGCTTCGTTGGGAGGTTSCTTGGCKCCTTCCGTSCCTGGKTTCKTTGGGCYCTCGAGAAGGTCTCCGCGGGMCGATTTCACSCGGGTTTGTGCASTTCTTTTGG >DeMo1.2 AGGGCGGAATCYAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCGTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGTGTGGGGGG >DeMo2 GAGGCCGATCTAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCGTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGTGTGGGGGGGCGAAGGKKGCGTGACGCCCAGGCAGGCKTGCCCTCGGCCTAATGGSTTCGGGSGCAACTTGCGTTCAAARACTCSATGATTCACGGGATTCTGCAATTCACACCARGYATCGCWTTTTGCTACGTT

    41

  • CTTCATCGATGCAAWACCCTAAATATCCGTTGCCAAAAGWYTTTGGTGTTTGGTGAAASWATTACAACCCCCCYTTACSTCTGATCGGAACGTTG >DeD1 GTGGCGRATCTCAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCGTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGTGTGGGGGGGCGAGGG >DeD2 GAGGCGATCTMGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCGTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGTGTGGGGGGGCGACGGGTGCGTGACGCCCMGGSAGGSGKGCCCTCGGSCTAATGGSTTCGGGCGCAACTTGCGTTCAAAGACTCKATGATTCACGGGATTCTGCAATTCACACCAAGTATCGCATTTTGCTACGTTCTTCATCGATGCSAGAGCCTAGATATCCGTTGCCSARAGTCKTTTGTGTTTGGTGAAACGACKACGACCCCCCRACGCGCCCGATCGGGACCGGGGCGACGGGAGCGCGTTGCTTCGTTGTGAGGTTCCTTGGCGCGTTCCGCGCCKGGGTTCGTTGTYCGCTCGAGAGGGCCGCCGCGGGMCGYCCCCCSCCCGTGCGCGGGGCACGACGGCGGGSGGGGCTCCCGGGGCCTCCCSAACGGGGGGAGGGGSGWWC >GuM13 CGGGSGSSCCRWATYYMAGCTGGGCTCTTCCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTKACGCGCGCGACGCCGAGCCGTGCRAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSMGGGSGMGGGRSSTSKGGGGGGRSGRMGGKKKSGKGAGGCCCAGGSWGGCGTGCCCTCRGGCTAATGGGTTCTGGCGCAACTTGCTTTCAAAGACTCTATGATTCACGGAATTCTGCATTTCCCACCAAGTWTCGTATTTTGCTACGWTCTTCTTCKATGCCAGAGCCTATATATCCGATGCCCARAGTCTYTTGTGCCKAGAGACACTACKACTACGTGACRACRCGCCCAATCGGGAACGGGGCGAART >GuM16 GTGGCCGAATCYAAGCTGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCGTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSMGGGSGMGGGRSSTSKGGGGGGRSGRMGGKKKSGKGRSG >GUM21 GGGYYWCGAAAGACCAATTSAGGGKGGGKYTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTKACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSAGGGGGAGGGASCTGKGGGGGGAGGAAGGKGGGGKGAGGCCACGGSWGGSKKGCCCCCRGGCTAATGGGTTCTGGSGCTAATTGCGTTCAAAGACTCTTGGATTCACGGGATTCTTGATTTCCCACCTTCATCRYATT

    42

  • TTGCTACKTTCTTCTTTTATGCCATAGCCTATATATCCGATACCCARAATAGYYTGTGCTKAGAGAAACKAGTACTACCCCAAAACACGACCACYCCSGACCGGGGCSACTGGAGAGCGGKGCTTCGGGGKGACGTTSCTTGGTTGGKTCTGTGCCTGGGTTCGTTGTCCGCTGGAGAGGGTCTCCGT >MaK1 TWGSWRGSRRTTYYARSCTGGGGSCTCYTTCCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCTTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGTCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCCMGGGSGCGGGGCCTCGGGGGGGAGGGAGGTGTGGGGGGGCGACGGGTGCGTGACSCCCAGGCAGGCGTGCCCTCGGCCTAATGGCTTCSGGCGCAACTTGCGTTCAAAGACTCSATGATTCACGGGATTCTGCAATTCACACCAAGTATCGYATTTTGCTACRTTCTTCATCGATGCGAGAGCCTARATATCCGTTGCCKAGAGTCRTTTGTGTTTGGTGAAACGACGACSACCCCCCRACGCGCCCRATCGGGACCGGGGCGACGGGAGCGCGTTGCTTCGTTGTGAGGTTCCTTGGCGCGTTCCGCGCCGGGRTWCGTTGTTCGCTCGAGAGGGCCGCCGCGGGCCGCCCCCCGCCCGTGCGCGGGGSAYGACGGCGGGYGGGGMTCCCGGGGMCTCCCGAACGGGGGGAGGGG > MaK2 TATGAGTGGCGATYMGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSMGGGSGMGGGRSSTSKGGGGGGRGGRAGGKGKGG >MaK3 AKKWRTACAGCSAATCTMGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSMGGGSGMGGGRSSTSKGGGGGGAGGRAGG >MaK4 AKKRRRWRKRGGTAGSCSATYMGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCSCCTCCCGTCCSAGGGGGAGGGRSSTSKGGGG >MaK5 GTGGCCGATCTAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSMGGGSGMGGGRSSTSKGGGGGGRSGRMGGKGGSGKGRSGCCCMGGSAGGSGKGCCCTCGGSCTAATGGSTTCKGGSGCAACTTGCGTTCAAAGACTCKATGATTCACGGGATTCTGSAATTCMCACCAAGTATCGCATTTTGCTACGTTCTTCATCGATGCSAGAGCCTAGATATCCGTTGCCSARAGTCKTTTGTGTTTGGWGAAACKACGACKACCCCCCGACGCGCCCRATCGGGACCGGGGCGACKGGAGMSCGTTGCT

    43

  • TCKTTGKGAGGTTCCTTGGSGCGTTCCGYGCCTGGGTTCKTTGTTCSCTCGAGAGGGYCGCCGCGGGCCGCCCCCCKCCCGTGCGCKGGTCACGACGTTGGGCGGGGCTCCCGGGGCCCTTGAACSGGGGGACGSAAAACKRT >PyM1 CGGGGCCTWTTTCCCAAMCTTGGGGCTCTTCCCGGKTCGCTCGCCGTTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTKACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSRGGGGGRGGGRGSTGKGGGGGGRGGRAGGGGGGGGGGGGCCCCGGGWGGGGGGCCCCCMGGCYRGYGGGTTCSGGGSCAAATTGCTTTCMAAGAAMCTTGGAATTAAGGGATTCTTGATTTCCCACCAAGGATCGSATTTTGCTACYATCTTCATTTGTTCCAGACTCTATATATGCGATGGCCAAAATYTYTTGTGKTTGGAGAAATTAMYACYAGCCCCCSASACGACCAATCCGGAACGGGGCCAAKGGAGACCGGTGCTTCGGTWGGRSGTTSCTTGGSKGGGTYCKYCCCTGGGGTCKTTYTTYCCTSGAAAAGGYCCCCGCTCGACAGCCCCCCCCCGGGCCSSGSGCACCACGGGCGGSGGGGATTCCGGGGGCCGCCGATCCGGGGGACGCCTGAACGGRGGGASGTTTTTTCTGTTTGTCGTAACAGATATKGTTTGTTRTTCCACGCCTCAWAAAGATAAGACKATAAAAGGTTTGTTATTTCTTTGKTARTGAGGWAAGGACTATAWAAATMAKACCCGCCTYTTCCTTCTAGTTTWAAAAAAACTAATATTAGCAACWAAAACCCTAAACTGGGGGTGTCTAMTRAYTTRAA >PyM1.3 GAGGGACGATCTCAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSRGGGGGRGGGRGSTGKGGGGGGAGGAAGGGGKGGGGGGGCCCCGGSAGGSGKGCCCCCCGGCTWATGGGTTCYGGGGCAACTTGCGTTCAAAGAATCSATGATTCACKGAATTTTTCCTTTCCCACCAAGTTTTTTATTTTGCTACGGTCTTCMTTSATGCCATARCCTAAATATCCCWTAGCCAAAATAGGTTGGGGTTGGGGAAAYYACCACCACCCCCCKAAACGACCCATCCGGAACGGGGCYACYTGAATTCGGTGTTTCSGGRKGAAGATGCTTGAYGAAATCCSCCCCYGGGAAATTTKTTYATCKGGAMCCCGCCGCCTTCCTGYTCCTTGAATTAAGATTGCSACCACTACCGRGCCKGYTTGCCGTGCCTAMSAATATGSGGGGAGGGACTTTAWGTCTGTTTGTCKTATAYAGAKAWGGCTTGTTATWWCKACGCCTCATAGAGCTYAGACTATAARARGGTRTKATATTTTTTTTWTTTTTTGTGGKRAGGAGGATARAAAWCTTATAATACCYCCYMCCCCCCTTTYYYCMARCTGYYTGCAGATATWRTCCTGAMCTSTCWCAAAGYSCAACTSTGACAAAGTKG >PyM2.3 TAGGGACGATCYAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTKACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSRGGGSGRGGGRGSKSKGGGGGGRGGGAGGGGGGGGGGGGCCCCGGGRGGRTTGCCCTCCGGCCTCCGGGGTCTGGGACTAATTGCGTTCMAAGAATCGAAKAATGAAAGAATTATTGAAATCTCTCCTCAWGGGTTTTTTTGCYAGAGGAGGGGTTGTGTGCGAAATMTTTGWAAACAGTCCCCAAGGTSTTMTGGGGRGAGGGGCTGCTTGAGCTCCCCCAACAAARAARAAAACCGGMACGGGGCAGACCGTTAATAATTTSTTCKTTGCCASGYAAAATAGGGCGGATGAAAYAAGGCCYKGTKAAATTATTAARATGATGGCTCCKCGGCRGCTTCSTGGTGGTTGAATTAAGYTGCRGCAATTACCTKCCT

    44

  • ATRTKTGCTTAASAAGAGTATGCAATGASGKACWKTAWGTCTGTTTGTCRYATAYAGAKAWGCTWGTTMTWMCGMCGCCTCATCKAGCTCAKACTATARWAGGTATGATRTTTCTTTAKTTRTGAGGTAAGGACKATARAAGATMATGATAWGMCKMYCMMCCYAGTTAYYMACTGTRYTAWGATAYYGWCCWGMAAYCRSTCMTGYAAATGTG >PyM3.4 GTGGGCGATCTCAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSRGGGSGRGGGRSSKSKGGGGGGRSGRAGGGGGGGGGGGGCCCCGGGWGGSSKGCCCCCSGGCTAATGGGTTCSGGGGCMACTTGGGTTCAAAGACTCTATGATTCACGGGATTCTGGAATTCCCMCCTARTATCGYATTTTGCTACSTTCTTCWTTGATGCCAGAAYCTAKATATCCGWTGCCCAAAGTCKTTTGTGTTTGGWGAAACKACKACTACCCCCCRAMRCGACCAATCSGGGACGGGGCSACYGGAGMCCGTTGCTTCGTTGGGAGGTTSCTTGGSGCGGTCCGYSCCSGGGTTCSTTGKTCSCTCGAAARGGSCKCCGCGCGACASCCCCCGCCCGTGCSCSGGGCAMSACGGGCGGCGGGGMTCCCGGGGKCCTGCGATWCGGGGGAAGSSCCAACG >PyM4.8 GCGCCGATCTCAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSRGGGSGRGGGRSSKSKGGGGGGRGGGAGGGGGGGGGGGGCCACRGGWGGSKKACCCCCCGGCTAACGGGTTCSGGGSCTAATTGCTTTYAAAAAATCTAARATTRAAAGAATTTTTGAATTCCGGGAARTGCATTTTTSCWAMGATCGTCTTTTGTTACAAAAMTTASCAAAGCGTTACCCAATATCTTTTGGGGTAAGGGAAAYSTCYACCARCCCCAACTACGACCAATCCGGAACGGGGCCAAYGGARATTTTTGYTATTGWGGCGAACTTGGSAGGAARAAWAAWTGCCGCGGAAAATTATTAAAATAGGGCCCCCCGGGAGGTTTCCKGCGCGTGTATTTAAAATTRCGGTWTTMCSMATCCCTGKGGTCTCSKAAACAAKAGAGYAYGGAGGGGCTTTMCAKTTTTTTTTTCTYATAMRMAAATGGTTGTTRTTACTACCTCCYCCTASAGCWMTAACTATASAAGGGAATGATTATTTTCTTTWTTTATTGKGGGKAGGGAKKAWRGAAATACAGATATGACATWTCCCCCTCGTTTTWKTAAWCTGAATGCWTAATATATAYGATMCWRGAACTGGAAAATCTTTGATTTKKTWTTWATGTTTT >DoK1 AGGGGRRAWWTCYYAGYTGGGGCTCTTCCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCGTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGTGTGGGGGGGSGRMGGGKGSGTGACGCCCMRGSAGGSGTGCCCTCSGSCTAATGGSTTCSGGSGCAACTTGSGTTCAAAGACTCSATGATTCACGGGATTCTGSAATTCMCACCAAGTATCGCATTTTGCTACSTTCTTCMTCSATGCSAGAGCCTARATATCCGTTGSCSARAGTCSTTTGTGTTTGGTGAAACGACSACSACCCCCCGAMGCGCCCSATCGGGAMCGGGGCGACSGGAGCGCGTTGCTTCSTTGKGAGGKTCCTTGGCGCGTTCCGCSCCSGGGTTCSTTGTTCSCTCGAGARGGCCGCCGCGGGCCGCCCCCCSCCCGTGCSCGGGGCACGACGGYGGGCGGGGYTYCCGGGGSCTCCCSAACSGGGGGAGGGGC >DoK2

    45

  • GAAGCGATCTMGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGRCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGTGTGGGGGGGSGACGGG >DoK3 GAGCCGATCTCAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCGTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGTGTGGGGGGGSGRMGG >BaM1 CCCGGCGAATTMYYAGGCTTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCGTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCSMGGGGGAGGGGGGTGTGGGGGGAGGGAGGKGKGGKGRGGCCAMGGSWGGSKKGCCCTCRGGCTRGTGGGTTCTGGSSCTACTGGCTTTCAAAGACTCTTGGATTCAAAGAATTCTGGATTTCMCGGATTCTATAATTTTTTGCTACKATCTTATTTTGTGCCATACTTTATATATGCGATASCCAAAATATTTTGTGTTTAGAGTAACTTGTACTAGGCGAARACACGACCAATCCSCAACGGGSCSAATGGAGASCGTTGCTACGGTAKSAGGTTGCTTGGYTCTGTCGKTSCTTGGSTTCTTTGTTSSCTCGATASGGTCKTCGCTCGACASCGCCSGCSCGTGCGCSCGCCAGSACGGGCGCSGGGSATCACGGSGSCTCGCGATCCSGGGGACTCCCGAACGGGGGGAGGK >BaM2 GTAGGCGGWTCTCAAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCGTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGCCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGMGGGGGGTGTGGGGGGASGGAGGKGGGGKGAGGCCACGGSWGGSKKGCCCCCAGGCTAGTGKGTCCTCGGSCAAMTGGCTTTCGGCGAAACTTGGATTCACGGACTTCTGGATTTCACACCTTCTATCGYATTTTGCTACKTTCTTCTTTTGCTCCAKTCTCTATATATGCGTTAGCCAAAATATTTTGTGCTTAGTGAYRTTAGTGTTAGGCCACAACACGACCACTCCSCAACGGGSCGAAKYGAGAGCGTGGCTACGGTAKSACGTTGCTTCGYGCTTTCCGCGCCTGGSTTCGTTGKTSSCGGGATACGTTGKTCGCTYGACAYGGCCCGCCCGTGCCCSGGGCCCCCCGTGCGGCGGGGMTCACGGSGSCTCGGGATCCGGGGGACGCYCGAACTSGGGGAG >BaM5 GAAATGACGGAGTCTCTAAGATCTTGTGTMTCTTTCCCAATTCTMGCGCCGTTACTAGGGGAATCCTTGTAAGTTTCYTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCTTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGTCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCCMGGGSGCGGGGCCTCSGGGGGGAGGGAGGTGTGGGGGGGCGACGGGTGCGTGACSCCCAGGCWGGCGTGCCCTCGGCCTAATGGCTTCSGGCGCAACTTGCGTTCAAAGACTCGATGATTCACGGGATTCTGCAATTCACACCAASTATCGYATTTTGCTACRTTCTTCATCKATGCGAGAGCCTARATATCC

    46

  • GTTGCCGAGAGTCGTTTGTGTTTGGTGAAACKACRACGACCCCCCRACGYGCCCRATCGGGGGCGGKGCGACGGGATCRCGTTGCTTCGTTGTGAGGTTTTTTGGMGCGTTTCTCGCCGGGGTACGTTGTTTTGCTCGAYAGGTCTKTCYCGGGYCGCCCCCTTCCTG >BeZ1 TKKWWRRRRRRAGCSTWYYMGCTGGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCTTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGTCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGGCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGTGTGGGGGGGGSGACGGGTGCGTGACGCCCAGGCAGGCGTGCCCTCGGCCTAATGGCTTCGGGCGCAACTTGCGTTCAAAGACTCGATGATTCACGGGATTCTGCAATTCACACCAAGTATCGCATTTTGCTACGTTCTTCATCGATGCGAGAGCCTAGATATCCGTTGCCRARAGTCGTTTGTGTTTGGKGAAACRACRACRACCCCCCRACSCGCCCRATCGGRACCGGGGCRACGGGAGCGCGTTGCTTCGTTGTGAGGTTCCTTGGCGCGTTCCGCGCCGGGGTTCGTTGTTCGCTCGAGAGGGCCGCCGCGGGCCGYCCCCCGCCCGTGCGCGGGGCACRACGGCGGGCGGGGCTCCCGGGGCCTCCCGAACGGGGGGGGAGG >BeZ2 TTGGGGSSSSGAWTYTYARCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCTTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGRCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGRGGTGTGGGGGGGGSRMSGGGKGSGGGASSCCCRGGMRGGSGGGCCCTCGGCCTAWGGGTTTCGGGCGCAATTTGSTTTCAAAAACTCRATAATTCACGGAATTCTGCATTTCMCACCARKATTCSMATTTTGCTACKTCCTTCTTCGATGCAAAAGCCTAAATATCCKTTGCCAAAAKYCKTTTGGGTTKGKKGAAMCRACAACAACCCCCCAACCSSCCCAATCGGAACSGGGSCAACGGRASCSSGTTGTTTCKTTGKGAGGTTCTTTGGSGCGTTCCSCSCCGGGGTTCKTTGTYCSTTCRAAAGGSCCSCSCSGGGCSGYCCCCCSCCCGTSCGCGGGGCACRACGGCGGGCGGGGYTCCCGGGSCYTCCCMAMCGGGGGRAGGGSRAA >BeZ3 ATTCAGAAGCGATCYAGCTGGGCTCTTCCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCTTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGTCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGRCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGRGGGGGRGGGRGGTGTGGGGGGGGCRACGGGTGCKTGACGCCCAGGCAGGCGTGCCCTCGGCCTAATGGYTTCGGGCGCAACTTGCGTTCAAARACTCRATGATTCACGGGATTCTGCAATTCACACCAAGTATCGCATTTTGCTACGTTCTTCATCRATGCRAGAGCCTARATATCCGTTGCCRARAGTCGTTTGTGTTTGGTGAAACRACRACRACCCCCCRACGCGCCCRATCGGRACCGGGGCRACGGGAGCGCGTTGCTTCGTTGTGAGGTTCCTTGGCGCGTTCCGCGCCGGGGTTCGTTGTTCGCTCGAGAGGGCCGCCGCGGGCCGYCCCCCGCCCGTGCGCGGGGCACRACGGCGGGCGGGGYTCCCGGGGCCTCCCGAACGGGGGGGAGG >BeZ4 CGGGKWTTWKGGGSCCSWAATSTYRRYTGGGGCTCTTTCCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCTTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGRCCAACCGCGGGCTGGGGCGCCCAC

    47

  • GGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGRGGTGKGGGGGGGGSRACGGGTGCGKGACSCCCAGGCAGGCGKGCCCTCGGCCTAAKGGYTTCGGGCGCAACTTGCGTTCAAAGACTCGATGATTCACGGGATTCTGCAATTCACACCAAGTATCGCATTTTGCTACGTTCTTCATCGATGCGAGAGCCTAGATATCCGTTGCCRAGAGTCGTTTGTGTTTGGKGAAACRACRACRACCCCCCGACGCGCCCGATCGGGACCGGGGCGACGGGAGCGCGTTGCTTCKTTGTGAGGTTCCTTGGSGCGTTCCGCGCCGGGGTTCGTTGTTCGCTCGAGAGGGCCGCCGCGGGCCGTCCCCCGCCCGTGCGCGGGGCACRACGGCGGGCGGGGYTCCCGGGGCCTCCCGAACGGGGGGAGGG >BeZ5 TGGGCGGAATYTCAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGRCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGRGGGGGRGGGRGGTGTGGGGGGGGSGACGGGGGSKTGASSCCCRGGMRGGSGGGCCCCCGGCCTATGGGTTTCGGGCCCACCTTGCTTTCAAAAACTCRATAATTCACGGAATTCTGCATTTCCCACCAAGTATCSCATTTTGCTCCKTCCTTCATCAATCCAAAAGCCTAAATTTCCKTTGCCAAAAGTCKTTGGGGTTGGGGGAAACAACAACAACCCCCCAASSCSCCCAAYSGGAACCGGGSSAACGGAAGCSCKTGGTTTCKTTKKAAGGTTCCTGGGSCCKTTCCSCSCCGGGKTTCKTGKTTCSTTCRRAAGGGCCSCSCCGGSCGSCCCCCCGCCCKKGCGCGGGSMACRACGGCGGSSGGGSYTCCCGGGSCTYCCCRAMSGGGGGGAGG >EaM17 TYCCTCTTTYGGRTTYAGSTGGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGRCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGRGGGRGGTGTGGGGGG >EaM18 TGCCCCTTAATAAGTTASGWYGGRCTCTTCTGGYRCGCTMGCCGCTGTAGGGGAATCCTTGTAGTTTCYTTTCCTCCGCTTATTGATWTGCTTAAACTCAGCGGGKGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCSAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGRCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGTGTGGGGGG >EaM20 CYYTTACCTYAYAGWRRKMGCRRKWYYMGYTKGGYTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCRAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGRCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGTGTGGGGG >EaM22 AWKWKRKRGRRGGGSCGWWTYYAGCTTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCGAGCCGTGCGAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGRCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGTGTGGGGG

    48

  • >EaM25 GGYKWYRKRKRRRGGCCWATYWAGCTGGGCTCTTCCGGTTCGCTCGCCGTTACTAGGGGAATCCTTGTAAGTTTCTTTTCCTCCGCTTATTGATATGCTTAAACTCAGCGGGTGGTCCCGCCTGACCTGGGGTCGCGATCGAGGGTCTCGGGCCKTTCTCGTGGGGGGCCCCTGAGGCGACGTGACGCGCGCGACGYCGAGCCGTGCRAAATCCACCGCTCGTCGTGGCGTACGTCGCCGCGGGACCGATTTTCGRCCAACCGCGGGCTGGGGCGCCCACGGGAGGCCAATGTCCGCCCCCTCTCCGCCTCCCGTCCGAGGGGGAGGGAGGKGTGGGGGG

    49