......2 1: . 1-5nm (University of Arkansas, USA). 5.......................3 2: (Johns Hopkins University, USA). 13............................................3 1. .......................................4In vitro ..........................................................4

Intellectum 04/ 08........................3 1: . 15nm (University of Arkansas, USA).............................5 In vivo ..........................................................6 .........................................................6

2. .........8 .........................................................8

2

Intellectum 04/ 08

........................13 2: (Johns Hopkins University, USA).13 ............................................14

3. ....................................16 .........................................................16 ........................................17 .......................................................17

1: . 1-5nm (University of Arkansas, USA)...........................5 2: (Johns Hopkins University, USA)................................................13

3

M . , . ( ) . ( ) (.. , ) (.. , ).

1. , . , .

In vitro in vitro . , , . ` . , , , , , , , , , . (chip), ,

4

Intellectum 04/ 08

DNA .

1: . 1-5nm (University of Arkansas, USA).

ex vivo , . , in vitro (biochips). , , , . : i. ii. iii. iv. , , , ( ) ( ) v. () , ,

5

vi. , .

In vivo in vivo (.. ), . (.. ). , , . in vivo , , , (theranostics). in vivo : i. , , - ii. iii. , (, , ) , iv. , (.. , , ).

AIDS. , / ,

6

Intellectum 04/ 08

. : i. ( ) ii. - / iii. / iv. v.- vi. vii. .

7

2. - . , . , , , , . , / (/) , . , . / , . . , , , , ( ) ., . , : , , , , , , .

- (10-100 nm) .

8

Intellectum 04/ 08

. in vivo . , / . (.. , RGD, , , ..) . . / . ( ) , (PEG). (.. ) PEG. . , . , , . - - -. ( - ) (.. PEG ). . - ( ) . ( ) , 10-1000 nm. . , - . . . -

9

(PLGA) / . PLGA (.., PVAgPLGA, SB-PVA-g-PLGA DEAPA-PVAg PLGA) PLGA , , .. CO2 . . , . in vivo. , , . / . / . . , / (.. , ). - / , , . . . . . . [.. , , ( ) ..] .

10

Intellectum 04/ 08

, , . pH, , , , , . (.. pH ). . - . , . , ( ). : , , , , , . . - . (.. , / ..). -SH . SH . / . ,

11

, . , , . . . (.. ). , : i. ii. iii. iv. .

12

Intellectum 04/ 08

2: (Johns Hopkins University, USA).

, . . , . - (.. , , , ..) - (MEMS) ( ) . , (stents), , . . , , - . - (micro-chips) : (.. , ) (.. , )

13

.

: , , : i. ii. iii. iv. , v. . . , , , , . , , - . i. : ii. in vitro iii. iv. in vivo

14

Intellectum 04/ 08

v. in vivo in vitro .

15

3. . , . , , . . / , , . . , . , , . . / , (biomimesis) . : , - .

, , . (.. pH, , , ) . - (.. ) . :

16

Intellectum 04/ 08

i. ii. iii. iv. v. vi. vii. , viii.- .

(.. , , ) . : - .

, , - . , , . , .

17

. : , , .

18