1997 other natural products

other natural productsU 0800

23 - 258Trypanocidal Activity of Synthetic Heterocyclic Derivatives of Ac-tive Quinones from Tabebuia sp. — The reaction of lapachol (I)and lapachones (VII), (XII) with glycine, ethyl α-aminoacetate and ammo-nium/benzaldehyde generates nitrogen heterocyclic compounds. The reactionand work-up conditions are optimized. The trypanocidal activity of thenaphthoheterocycles shows no concordant behavior in relation to the parentcompound. The most active compound is the naphthoimidazole (XI). —(PINTO, A. V.; PINTO, C. N.; PINTO, M. C. F. R.; SANTA RITA, R.;PEZZELLA, C. A. C.; DE CASTRO, S. L.; Arzneim.-Forsch. 47 (1997) 1,74-79; Lab. Biol. Cel., Dep. Ultra-estrutura Biol. Cel., Inst. Oswaldo Cruz,21045 Rio de Janeiro, RJ, Brazil; EN)

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